Digital Commons Network^™

Asymmetric Synthesis Of The Hiv Protease Inhibitor Tmc-126, A Pmx Antimalarial Protease Inhibitor, And A Putative Covid-19 Inhibitor Using A Highly Stereoselective Glycolate Aldol Addition Reaction Pathway, Kweku Amaning Affram, Austin Carter, April Breede, Alexandra Kimsey, Godson Hemeson, Bader Semakieh, Moses Martinez, Emmanuel Ayim, Joy Odeh, Shawn R. Hitchcock

Faculty Publications – Chemistry

An asymmetric glycolate aldol addition pathway was developed for the synthetic preparation of a series of protease inhibitors based on the hydroxyethylamine structural motif. A single glycolate aldol adduct derived from a highly diastereoselective (≥95:5 d.r.) asymmetric aldol reaction served as the starting point for the synthesis of the inhibitors. The starting material is easily prepared and purified via recrystallization on multigram scales. This work describes the synthesis of the HIV protease inhibitor TMC-126, the Plasmepsin X (PMX) inhibitor 49c for the treatment of malaria, and a computationally derived inhibitor for the 3CLpro of the SARS-CoV-2 from a single common …

Advancing Interoperability Through Governance And Sustainability: A Qualitative Comparative Case Study Of State Health Information Exchanges In The United States, Karterria Finkley

College of Graduate Studies: Theses & Dissertations

This study presents a comprehensive comparative analysis of state-level Health Information Exchanges (HIEs) across all 50 U.S. states and the District of Columbia, examining how governance structures, consent frameworks, funding models, and technical infrastructure influence interoperability maturity, sustainability, and adoption. Guided by Systems Theory and Donabedian’s Structure Process Outcome framework, the research employs a mixed-methods comparative case design integrating systematic documentary review, qualitative thematic analysis, and a policy-anchored analytic scoring methodology. Structural and policy characteristics were operationalized through standardized ordinal (1-5) metrics and aggregated into composite indices representing governance capacity, consent inclusivity, financial sustainability, and technical readiness. This approach enabled …

Association Between Internet Use For Health Information And Alzheimer’S Disease Diagnosis Among Older Adults With Diabetes In The United States: Examining Racial And Gender Disparities, Henry M. Zeidan

College of Graduate Studies: Theses & Dissertations

This study uses data from the National Health and Aging Trends Study (NHATS) Round 13, collected in 2024, to examine whether internet use for health information is associated with Alzheimer’s disease diagnosis among older adults with diabetes in the United States. Given the rising adoption of digital health, understanding who benefits from online health resources is increasingly important. The research also examines whether these associations differ across racial and gender groups, offering insight into potential disparities in digital health engagement and cognitive outcomes. Findings from this study will inform clinical practice, public health programming, and strategies to ensure equitable access …

Examining How Engagement Strategies Of Principals Influence Teacher Retention In Urban Title I Schools, Bridgette Allen

College of Graduate Studies: Theses & Dissertations

As the teacher shortage continues to rise, it is critical for educational leaders to focus on teacher retention. Principals play a significant role in teacher retention, teacher engagement, and job satisfaction; therefore, they must implement effective engagement strategies to improve teacher retention. The purpose of this basic qualitative study is to explore how engagement strategies employed by principals at urban Title I schools contribute to teachers’ decisions to remain at these schools. The research question for this study examines teachers’ perspectives on how the engagement strategies used by their school principals influence their decision to remain in an urban Title …

Exploring Teacher Perceptions: A Comparative Analysis Of Departmentalized And Self-Contained Instructional Models In First And Second Grades, Jason R. Trotter

College of Graduate Studies: Theses & Dissertations

This qualitative multiple-case study examined the perceptions of first- and second-grade teachers who have taught in both the departmentalized and traditional self-contained instructional models. The study explored teachers’ perceived advantages and disadvantages of each model, examined how their experiences within each model influenced instructional strategies and classroom management approaches, and assessed their perceived impacts on student engagement and learning outcomes. Each grade level was a bounded case. This study was conducted at a Title I elementary school in Southeast Georgia, where both models were implemented.

Guided by social constructivism, semi-structured interviews were conducted with seven teachers (four first-grade and three …

Staff Perceptions Of The Roles, Responsibilities, And Effectiveness Of School Resource Officers In Ensuring School Safety, Jana B. Collins

College of Graduate Studies: Theses & Dissertations

School safety remains a critical concern in education, particularly in rural settings where resources, staffing, and community dynamics may differ from urban and suburban environments. The purpose of this quantitative study was to examine staff perceptions of the roles, responsibilities, and effectiveness of school resource officers in maintaining and enhancing school safety within a rural school system. A researcher-designed survey using a 4-point Likert scale was administered to teachers and staff members (N = 417). Descriptive statistics summarized overall staff perceptions, and analyses of variance (ANOVAs) examined differences based on demographic and professional characteristics. Findings indicated that staff generally …

Math Toxicity: A Psychoanalytic Examination Of Blips And Belonging In Mathematics Education, Kimberly R. Kirstein

College of Graduate Studies: Theses & Dissertations

This dissertation examines how secondary mathematics education functions not only as a curricular and institutional structure but as a lived, relational, and affective experience for students. While mathematics education research has extensively documented patterns of achievement, access, and anxiety, far less attention has been given to how students come to experience mathematics as a site of threat, shame, and diminished worth. This study introduces the concept of math toxicity to describe the cumulative harm produced when mathematics operates as a gatekeeping mechanism that links performance to identity and value. Drawing on historical analysis, psychoanalytic theory, and autobiographical inquiry, this research …

Extracurricular Activities' Influence On High School Students' Academic Achievement, Michael Jones Jr

College of Graduate Studies: Theses & Dissertations

This quantitative study investigates the relationship between participation in extracurricular activities and academic achievement among high school students, as measured by Grade Point Average (GPA). This study uses a cross-sectional research design to analyze GPA data from Greenbrier High School in Evans, Georgia. Greenbrier is a part of the Columbia County School District and serves approximately 2,000 students. Historical data were collected from 2024-2025 school records and analyzed using t-tests and ANOVA to compare the impact of ECAs on academic achievement. The study analyzed differences in academic performance based on (a) participation versus non‑participation in ECAs, (b) the type of …

The Impact Of A Nf-Κb Signaling Inhibitor On The Antibacterial Activity Immune Response In The Cat Flea (Ctenocephalides Felis), Caroline M. Singer

College of Graduate Studies: Theses & Dissertations

Ctenocephalides felis are vectors of several bacterial pathogens that cause disease in humans and animals, including Bartonella henselae and Rickettsia felis. Successful pathogen transmission requires that microbes survive the immune defenses of the flea digestive tract following blood feeding. In insects, humoral immune responses are regulated primarily by the Toll and immune deficiency (IMD) signaling pathways, with the IMD pathway serving as the principal defense against Gram-negative bacteria. Although genomic and transcriptional evidence indicate that cat fleas encode and express components of the IMD signaling pathway, the functional roles of individual pathway components within the flea digestive tract remain …

The Efflorescence Of Apocalypticism (Imminent & Prepping Beliefs): Considering Informational And Motivational Regulatory Mechanisms, James T. Good Mr.

College of Graduate Studies: Theses & Dissertations

In the last quarter of the 21st century, apocalyptic beliefs emerged in scholarly and lay representations notably doubling over the last decade. With nearly forty percent of United States citizen reporting this belief, unfulfilled questions arose: What drives discrepancies in beliefs of an imminent end of the world? Additionally, what drives beliefs in the need to prepare for an end of the world? These individual questions were examined together in this study using Construal Level Theory (CLT) and Regulatory Focus Theory (RFT) in an attempt to identify how psychological mechanisms are significantly affecting the fluctuations, in these self-reported beliefs. A …

A Unified Automated And Explainable Ai Framework For Drug Discovery, Clinical Diagnostics, And Public Health Data Prediction, Lord Coffie

College of Graduate Studies: Theses & Dissertations

This thesis investigates the development of automated, explainable artificial intelligence systems to improve automated scientific discovery, clinical diagnostic support, and public health decision-making. Three independent yet thematically aligned studies were conducted across cheminformatics, radiology, and population health. Study A introduces an automated and explainable machine learning pipeline for Quantitative Structure–Activity Relationship (QSAR) modeling using RDKit-derived molecular descriptors. The pipeline performs systematic preprocessing, consensus-based feature selection (mutual information, random forest importance, RFECV), and benchmarks six supervised models—Random Forest, XGBoost, Support Vector Machine, Balanced Random Forest, EasyEnsembleClassifier, and a blended meta-ensemble, achieving AUC = 0.90 and accuracy = 0.83, while ensuring interpretability …

Experiencing Followership: A Hermeneutic Phenomenological Study Of Executive Assistants In Higher Education, Trina R. Smith

College of Graduate Studies: Theses & Dissertations

The burgeoning study of followership needs more follower-centric qualitative research that describes follower beliefs, attitudes, perceptions, and experiences. The traditional view of leadership is that a single person is responsible for the success or failure of a project, team, or organization. However, scholars have suggested that 80% of the success of a team or organization may be attributed to followership. Followership research is rapidly expanding, and scholars are calling for more empirical follower-centric research to add to the discipline. Likewise, the executive assistant (EA) position is one of increasing responsibility, but there are few empirical studies on EAs' experiences across …

Varying Dna Methylation Patterns In The Florida Sand Skink (Plestiodon Reynoldsi) In Relation To Fire Histories, Victoire Hj Litre

College of Graduate Studies: Theses & Dissertations

Epigenetics is the study of changes in phenotype not caused by changes in DNA sequence. DNA methylation is the most well-studied epigenetic mechanism in an ecological context. Reptiles use DNA methylation to respond to environmental stressors and differences among habitats. The Florida Sand Skink (Plastidome reynoldsi) is federally listed as a threatened species. They are endemic to the threatened, fire-dependent Florida scrub habitat. As they persist in burned habitats, the Florida Sand Skink must be able to rapidly respond to wildfires. To better understand how the Florida Sand Skink adjusts to fire-driven habitat changes, it is important to …

Viscoelastic Behavior Of Magnetically Filled Pdms Elastomers: Influence Of Filler Loading And Particle Type, Madison Procyk

College of Graduate Studies: Theses & Dissertations

Magnetorheological elastomers (MREs) offer a promising pathway for soft, magnetically actuated drug‑delivery systems, yet material‑selection guidelines remain unclear due to limited comparative data across particle chemistries, size scales, and concentrations. This study systematically evaluates how magnetic filler type (carbonyl iron and magnetite) and particle size (micro vs. nano), at two weight percentages – 40 wt% and 50 wt% – in Sylgard 184 PDMS influence the viscoelastic behavior of MREs intended for compliant biomedical actuation. Eight particle formulations were prepared through sieving, controlled mixing, vacuum degassing, and isotropic curing, producing nineteen total specimens (16 with filler particles and 3 without). Dynamic …

A Real-Time Autonomous Mobile Robotic System For Crack Detection And 3d Laser Profiling In Construction Using Two-Stage Deep Learning, Emmanuella Ogun

College of Graduate Studies: Theses & Dissertations

This thesis presents an autonomous mobile robotic system that integrates real-time visual crack detection with laser-based three-dimensional profiling for building inspection. The system coordinates SLAM-based navigation, deep learning perception, and manipulator-guided measurement within a unified ROS 2 framework, enabling scan-on-demand workflows where laser profiling occurs selectively at visually detected defect locations. The detection pipeline employs a two-stage architecture combining U-Net semantic segmentation with Pix2Pix residual refinement, achieving 73.9% mean intersection-over-union and 76.4% F1-score on the CrackSeg9k benchmark while maintaining 16 frames-per-second real-time throughput. Real-world validation demonstrated 95% detection success on 80 campus images under challenging conditions. The profiling subsystem utilizes …

Ai-Driven Real-Time Detection Of Zero-Day Browser Exploits Using Webassembly-Based Instrumentation, Temitope Damilola Elijah

College of Graduate Studies: Theses & Dissertations

The rapid evolution of web browsers into fully fledged application execution environments has significantly expanded their attack surface, making them prime targets for sophisticated zero-day exploits that evade traditional signature-based security mechanisms. To address this challenge, this research proposes an AI-driven framework for real-time detection and analysis of zero-day exploits in web browsers by integrating browser-level telemetry monitoring, unsupervised anomaly detection, and large language model–based threat interpretation. The framework introduces a lightweight WebAssembly telemetry agent embedded within the browser runtime to capture low-level execution behaviors, including WASM module instantiation, memory growth patterns, network interactions, and runtime API activity. These telemetry …

Independent And Interactive Effects Of Stack Height And Heel Width On Spatiotemporal Parameters, Knee Joint Kinetics, And Ground Reaction Forces During Running, Hao Cai

College of Graduate Studies: Theses & Dissertations

This study investigated the independent and interactive effects of stack height (SH) and heel width (HW) on lower-extremity biomechanics during running. Specifically, the study examined how variations in midsole geometry influenced spatiotemporal parameters, knee joint kinetics, and ground reaction forces (GRF). Twelve recreational runners (8 males, 4 females) completed treadmill running trials at 16 km/h under nine shoe conditions that systematically varied in SH (25, 45, and 65 mm) and HW (81, 93, and 105 mm). Lower-extremity kinematics were collected using a Theia3D markerless motion capture system, and GRF data were recorded using an instrumented treadmill. A two-way repeated-measures ANOVA …

Influence Of Footwear Geometry On Lower Limb Stiffness During Running, Hongjiao Duan

College of Graduate Studies: Theses & Dissertations

This study examined how footwear geometry, specifically stack height and heel width, influences lower-limb stiffness during treadmill running. Twelve recreationally active runners completed treadmill running trials at 4.44 m/s in nine prototype shoe conditions that differed in stack height (25, 45, and 65 mm) and heel width (81, 93, and 105 mm). Vertical stiffness, leg stiffness, and sagittal-plane hip, knee, and ankle joint stiffness were calculated from synchronized markerless motion capture and force data. A two-way repeated-measures ANOVA (stack height X heel width) was used to test footwear effects. Leg stiffness was not significantly affected by stack height or heel …

Celebrities, Personalities, And Drinking Styles, Madeleine Krueger

College of Graduate Studies: Theses & Dissertations

This study replicated and extended the findings of Hill et al. by examining the influence of sociocultural factors, vulnerable and grandiose narcissism, and related psychological variables on drunkorexia behaviors. The replication was expanded to include body dissatisfaction and celebrity worship, as prior literature suggests these variables may be strongly associated with disordered eating and alcohol-related compensatory behaviors. Results indicated that body dissatisfaction emerged as a significant predictor of drunkorexia, supporting previous research that links negative body image with maladaptive weight-control behaviors surrounding alcohol consumption. Several limitations should be noted, including the use of a single-university sample, reliance on a cross-sectional …

Recruitment Strategies For Rural Black Students At Georgia Colleges And Universities: From An Admissions Counselor Perspective, Jayde B. Nelson

College of Graduate Studies: Theses & Dissertations

This dissertation explores the recruitment practices of admissions counselors at colleges and universities in the state of Georgia, with a focused lens on their efforts to engage and enroll Black students from rural high schools. The study investigates how geographic isolation, racial identity, and systemic inequalities converge to shape the college access landscape for underrepresented students in rural communities. Using a qualitative approach grounded in Culturally Responsive Leadership as the theoretical framework, this research examines the strategies, barriers, and institutional priorities that influence outreach efforts and recruitment outcomes. By analyzing admissions counselor perspectives and institutional approaches, the study found that …

Assessing Climate-Driven Shifts In Floral Resource Availability For Bees On Barrier Islands In The Southeastern U.S., Hannah Brown

College of Graduate Studies: Theses & Dissertations

Climate change can alter the timing of bee and angiosperm phenology, potentially reshaping the seasonal availability of floral resources for bee species. Although plant-pollinator phenology has been widely studied in temperate systems, less is known about these dynamics in subtropical coastal ecosystems, such as barrier islands in the southeastern United States. In this study, we examined climate-driven changes in bee activity and floral resource availability across 16 barrier-island sites spanning from Florida to Virginia. Using museum bee occurrence records, herbarium-derived flowering phenology models, site-specific floristic inventories, and published bee-plant interaction data, we estimated species-specific bee activity periods and daily floral …

A Program Evaluation Research Study Of The Implementation Of Mothers With Mentors: A Dissertation On Shelter From The Rain’S Mentorship Program, Danielle Louise Smith

College of Graduate Studies: Theses & Dissertations

This program evaluation study examines the implementation of the 2025 Shelter From the Rain “Mothers with Mentors” program in Savannah, GA. Utilizing a convergent parallel mixed-methods approach, the study evaluates the program’s acceptability, feasibility, and perceived benefit through the theoretical lenses of the Theory of Planned Behavior (TPB), the Health Belief Model (HBM), and Bonding Social Network (BSN). The analysis incorporates quantitative and qualitative data for participant mentees (n=7) and mentors (n=12), with a specialized paired analysis of five mentor-mentee matches.

The findings indicate a complex landscape of convergence and divergence across the groups. Quantitative results depicted high convergence on …

Influence Of The Sst K-Ω Stress-Limiter Coefficient On Transonic Shock Buffet Prediction For The Oat15a Supercritical Airfoil, Melinawo Vowotor

College of Graduate Studies: Theses & Dissertations

Transonic shock buffet predictions using the Shear Stress Transport (SST) k–ω turbulence model are known to be sensitive to the stress-limiter coefficient a₁, yet no systematic investigation of this sensitivity exists. This thesis presents a parametric study of a₁ for two-dimensional URANS simulation of shock buffet on the OAT15A supercritical airfoil at M = 0.73 and Re = 3 × 10⁶. Eleven a₁ values (0.25–0.37) are examined at α = 3.5°, and a matrix of five a₁ values across five angles of attack (3.0°–3.9°) maps the interaction with incidence. The results reveal that a₁ acts as a bifurcation parameter: a …

Impact Of Religion On Mental Outcomes Among Racial/Ethnic And Sexual/Gender Minority Individuals, Braden J. Waugh, Michael E. Nielsen

College of Graduate Studies: Theses & Dissertations

Marginalized identities (Adams & Miller, 2022) are associated with elevated risks for negative outcomes (Ching et al., 2018; Kayode et al., 2024). Religion has been found to act as a protective and risk factor. Minority Stress Theory (Meyer, 2003) and Intersectionality Theory (Crenshaw, 1991) are used to examine the relationship between identity status and anxiety, prosocial tendencies (PT), and quality of life (QoL). One hundred fifty-two participants were primed with a religious or neutral stimulus, and then answered measures regarding these outcomes (GAD-7, Spitzer et al., 2006; PBIS, Baumsteiger & Siegel, 2019; WHOQOL-BREF, The Whoqol Group, 1998; IFS, Hammer & …

Assessing The Diversity And Composition Of Crayfish Assemblages In The Ogeechee River Basin, Reginald Turner

College of Graduate Studies: Theses & Dissertations

Crayfish assemblage composition in the southeastern United States is understudied relative to other aquatic taxa, such as aquatic insects and fishes, and the Coastal Plain watersheds of that region are particularly underrepresented in the contemporary literature on this topic. For example, although 38% of the crayfish species in Georgia are considered “species of greatest conservation need,” most of the distributional data used to make these designations are outdated, with some dating back over 50 years. This thesis sought to update our understanding of the contemporary distributions of crayfish species within the Ogeechee River Basin (ORB), a watershed in southeastern Georgia …

Assessing And Advancing Pandemic Emergency Preparedness In New York City's Hospitals: A Strategic Management Toolkit Integrating Policy Analysis, Risk Assessment, And Stakeholder Insight, Irrem Jamal

College of Graduate Studies: Theses & Dissertations

This dissertation examines pandemic emergency preparedness in New York City hospitals, which were severely strained during COVID-19, revealing critical gaps between documented plans and operational readiness. Using a multimethod approach combining a survey of 20 stakeholders across city hospitals, semi-structured interviews, and document analysis of policy frameworks and after-action reports, the study identifies a persistent "documentation-execution paradox": while 80% of respondents confirmed clear pandemic plans, only 45% expressed confidence in staffing adequacy, 55% in surge planning realism, and just 45% confirmed regular drills. Qualitative analysis revealed workforce as the single greatest yet most underinvested vulnerability, supply chain fragility rooted in …

Swimming In Uncertainty: Filling Data Gaps And Providing An Educational Platform For Beach Water Quality At Tybee Island, Georgia, Lukas Roberson

College of Graduate Studies: Theses & Dissertations

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Swimming in beaches water contaminated with high levels of bacteria can make you sick. Current monitoring at the public beaches on Tybee Island consists of weekly monitoring and enumeration of fecal indicator bacteria that takes 24 hours for results. If the number of bacteria exceed regulatory limits, a public health advisory is issued, and affected waters are retested until …

The Effect Of Complexity Of Expert Testimony And The Presence Of A Defensive Rebuttal On Jurors' Decisions In Criminal Trials, Shelby E. Madden

College of Graduate Studies: Theses & Dissertations

Forensic science plays a critical role in criminal trials, yet forensic techniques vary in their reliability. Expert testimony, often held in high regard by jurors, can be a decisive factor in verdicts, but its influence is complicated by factors such as technical complexity, adversarial bias, and heuristic processing. The present study examined how the complexity of prosecution expert testimony and the presence of a defensive rebuttal influenced jurors’ decisions when presented with faulty forensic evidence. Participants (N = 142) were randomly assigned to one of four conditions in a 2 (testimony complexity: high v. low) x 2 (defensive rebuttal …

Examining Firefighter Perceptions Of Stress And Recovery Across A Shift And Engagement In Recovery Activities, Nathan T. Ebersole

College of Graduate Studies: Theses & Dissertations

The occupational demands of firefighting, such as fire suppression and rescue tasks, working in hazardous conditions, inconsistent sleep patterns, and exposure to traumatic events, can lead to work-related injuries, burnout, and feelings of isolation. To date, there is limited research on the impact of a single work-shift on firefighter perceptions of stress and recovery and the recovery activities that may influence these perceptions. Thus, the purpose of this study was to examine the effect of a single work-shift on firefighter perceptions of stress and recovery status as well as the recovery activities firefighters choose to engage in. Forty-three firefighters across …

Professional Learning Community Implementation And Perceptions Of Influence On School Culture, Herbert L. Chambers Jr.

College of Graduate Studies: Theses & Dissertations

As school leaders strive to achieve educational success at all levels in schools, this research provided educational professionals with feedback on how the implementation of professional learning communities (PLCs) is perceived as influencing school culture. The purpose of this non-experimental quantitative survey design was to examine how educators perceived that school culture is influenced by the practice of PLCs. Descriptive statistics were calculated for 57 survey items. This research design provided the perceptions of school leaders, teachers, and support staff at the elementary, middle, and high school levels based on five identified dimensions of the Professional Learning Community Assessment – …