The Effect That Positive And Negative Self-Concepts Have On Adolescents' Behavior And Personalities, Portia L. Davis

Murray State Theses and Dissertations

Abstract

The development stage of adolescence is a complex process in which adolescents begin to explore their identity and form either a positive or negative self-concept. Self-concept plays a crucial role in shaping adolescents' personalities and behaviors. Self-concept includes how adolescents view themselves and how others see them. An adolescent's self-concept can influence their self-confidence, social relationships, and decision-making abilities. This study examines the relationship between overall self-concept and adolescents' personality traits and behaviors. To gather this information, a quantitative research design is used, in which adolescents complete assessments such as the Tennessee Self-Concept Scale (TSCS), the Woodcock-Johnson IV (WJ-IV), …

Career And Technical Education Readiness Trends Across Kentucky High Schools And Workforce Regions: A Longitudinal Analysis, Brittany Forgey

Murray State Theses and Dissertations

Career and Technical Education (CTE) has become an increasingly important component of Kentucky’s educational accountability system and workforce development initiatives. Despite expanded emphasis on career readiness and technical skill attainment, limited research has examined long-term trends in CTE readiness across Kentucky public high schools. The purpose of this quantitative, non-experimental, longitudinal study was to examine trends in CTE readiness indicators from 2011 through 2025. Human Capital Theory and Social Capital Theory provided the conceptual framework. Publicly available data from the Kentucky Department of Education School Report Card, KYStats, Supplemental Career and Technical Education reports, and other Kentucky Department of Education …

Lack Of Disparities In Postoperative Care After Ileocecal Resection In Patients With Crohn's Disease At Tertiary Inflammatory Bowel Diseases Centers, Shannon Coombs, Molly Powell, Kemmian Johnson, Jessica Hu, Mollie Webb, Philip Mcdaniel, Parakkal Deepak, Edward L Barnes

2020-Current year OA Pubs

BACKGROUND: Prior studies suggest that longer drive time (DT) to specialists and higher area deprivation index (ADI) are linked to worse outcomes in inflammatory bowel disease (IBD), but their impact on postileocolic resection (ICR) care in patients with Crohn's disease (CD) is not well defined.

OBJECTIVES: We aimed to evaluate disparities in post-ICR care based on DT and ADI.

METHODS: Spatial analysis was performed with ArcGIS Pro to geocode patient and medical facility addresses with StreetMap Premium locators. High DT was defined as >60 min from the center. Data were analyzed using basic statistics and multivariate logistic regression.

DESIGN: A …

Effect Of A Pregnancy Lifestyle Intervention Embedded Into A Home Visiting Program On Child Neurodevelopment, Sarah S Farabi, Rosemary Bass, Amit Mathur, Cindy Schwarz, Candice Woolfolk, Richard Stein, Samuel Klein, Debra Haire-Joshu, Alison G Cahill

2020-Current year OA Pubs

Maternal obesity is associated with a higher risk of abnormal child neurodevelopment. The aim of this study was to determine the effect of a lifestyle intervention embedded into a home visiting program, Parents as Teachers (PAT), on 18-month neurodevelopment in the offspring. Pregnant women (9-15 weeks) of African American Race, 18-45 years old, first-trimester BMI 25.0-45.0 kg/m

Application Of Machine Learning To Blood-Based Biomarkers Of Alzheimer's Disease In Down Syndrome, Patrick H Luckett, Melissa Petersen, Sid O'Bryant, Mark Mapstone, Brad T Christian, Benjamin Handen, Elizabeth Head, Beau M Ances, Alzheimer's Biomarker Consortium‐Down Syndrome

2020-Current year OA Pubs

INTRODUCTION: Blood-based biomarkers can improve Alzheimer's disease (AD) characterization in Down syndrome (DS). This study applied hierarchical clustering and machine learning-based feature selection to identify biomarkers associated with disease progression.

METHODS: Cross-sectional blood-based biomarkers were analyzed from 211 DS participants (

RESULTS: The strongest predictors overall were neurofilament light chain (NfL), tau/amyloid beta (Aβ)40, Aβ42/Aβ40, alpha-2-macroglobulin (A2M), and interleukin (IL)-10. Within the CS group, NfL, tau/Aβ40, A2M, and IL-10 were strong predictors. In MCI, Aβ42/Aβ40, NfL, A2M, and IL-10 were strong predictors. In DS-AD, Aβ42/Aβ40, NfL, and tau/Aβ40 were the top predictors. Cluster membership varied based on disease stage.

DISCUSSION: …

2025 Engage For Change Awards Program, Bonner Center For Civic Engagement

Engage for Change Awards

2026 Award Print: Hamilton Glass

Keynote Speaker: Hamilton Glass

Identification Of Distinct Subtypes In Immune Tolerance After Hematopoietic Cell Transplantation Using The Prospective Able1.0 Pediatric Study Cohort, Bernard Ng, Shalini Shenoy, Et Al.

2020-Current year OA Pubs

The lack of immune tolerance after hematopoietic cell transplantation (HCT) can result in chronic graft-versus-host disease (cGvHD), which is the primary nonrelapse limitation of successful HCT. To date, immune tolerance has been considered a single biological entity, but we hypothesized that post-HCT immune tolerance could develop through multiple pathways. Using the ABLE network database, which comprises measurements of 75 cell populations, 10 cytokines and chemokines, lymphocyte population telomere length, KRECs and TRECs, and 132 metabolites from the largest pediatric cGvHD cohort (n = 241), we applied clustering analysis to patients with primary immune tolerance (PIT; no acute GvHD [aGvHD] or …

Identifying Disparities In Same-Day Surgery Cancellations: Impact Of Race And Socioeconomic Factors In A Pediatric Health System, Nicole M Santucci, Daniel Alligood, Amanda Maytin-Hevia, Danyi Wang, Kelly Chilson, Jesse Vrecenak, Andrew Yeh, Colin A Martin

2020-Current year OA Pubs

PURPOSE: Same-day surgery (SDS) cancellations have significant implications on patients and hospitals. This study aimed to identify demographic and socioeconomic factors that impact SDS cancellations across a single pediatric health system.

METHODS: A case-control retrospective review captured patients (age < 18) who underwent SDS procedures from July 2022 to August 2024. Patients were included if they underwent any procedure at three operative sites: a tertiary pediatric academic hospital (PAH) and two outpatient surgery centers (OSC). Patients whose SDS was cancelled (n = 2,034) were compared to those whose surgeries proceeded as scheduled (n = 25,573). Patient zip codes were matched to Child Opportunity Index (COI) 2.0 data.

RESULTS: The overall SDS cancellation rate was 7.37 %, with a significantly higher rate observed at the PAH compared to OSC (11.4 % vs 53 %, p < 0.001). Patients with cancelled cases were more likely to identify as Black and have the lowest quintile COI (p < 0.001). Cancelled in preop and no shows were two reasons with the most racial disparities. In a sub-analysis comparing cancelled cases between operating sites, PAH cancelled patients tended to be Black (23.8 % vs 11.7 %, p < 0.001) and have very low COI (20.1 % vs. 10.6 %, p < 0.001).

CONCLUSION: SDS cancellation rates are significantly higher amongst patients who identify as Black and reside in low opportunity neighborhoods. Disparities in cancellation rate are more significant in patients scheduled at the urban PAH compared …

Foot-Specific Exercise Intervention For Forefoot Deformity In Individuals With Type 2 Diabetes And Peripheral Neuropathy: A Randomized Controlled Clinical Trial With 3-Year Follow-Up, J A Zellers, K Steger-May, P K Commean, H-J Jeong, E M Bullard, M J Mueller, M K Hastings

2020-Current year OA Pubs

BACKGROUND: Diabetes with peripheral neuropathy can lead to metatarsophalangeal joint (MTPJ) deformity. The purpose of this study was to estimate the effect of a foot-specific intervention on MTPJ deformity. Secondary aims were determining MTPJ deformity progression over 3 years and predictors of MTPJ deformity progression.

METHODS: Sixty people with type 2 diabetes and peripheral neuropathy were recruited for this randomized controlled clinical trial. Participants were assessed at baseline, 6 months (post-intervention), 1.5 years, and 3 years. A 6-month, foot-specific intervention in the experimental group was compared to a shoulder intervention in the control group. The primary outcome was change in …

Clinical Outcomes Following Mechanical Thrombectomy In Pulmonary Embolism Response Team-Consulted Patients: A Retrospective Analysis, Ryan Nolan, Maanasi Samant, Suresh Vedantham, Westley Ohman, Nathan Droz, Kristen Sanfilippo, Pavan Kavali

2020-Current year OA Pubs

PURPOSE: To determine if use of mechanical thrombectomy (MT) impacts survival and additional outcomes in patients with acute intermediate-high-risk and high-risk pulmonary embolism (PE) who were evaluated by a Pulmonary Embolism Response Team (PERT).

METHODS: This retrospective, single-center study included patients with intermediate-high-risk and high-risk PE who received PERT evaluation over 3.5 years and were treated with anticoagulation (AC) alone or MT + AC. The primary outcome was 30-day all-cause mortality, measured with inverse probability of treatment weighting. Exploratory outcomes included survival during the study period, PE-associated/caused mortality, hospital length of stay (LOS), supplemental oxygen at discharge, and MT-related metrics. …

Focused Ultrasound-Enhanced Nose-To-Brain Delivery Of A Therapeutic Antibody In A Large-Animal Model, Siaka Fadera, Cristian Antonio Wieczorek Villas Boas, Yimei Yue, Zhaoning Gu, Jinyun Yuan, Debolina De, Buck E Rogers, Arash Nazeri, Hong Chen

2020-Current year OA Pubs

No abstract provided.

Oculomics And Ai: The Eye As A Biomarker For Health Span, Joy Le Yi Wong, Rajendra S Apte, Et Al.

2020-Current year OA Pubs

As the world's population ages, the focus of healthcare is shifting from extending life span to promoting health span. There is an unmet need to identify sensitive and reliable markers of health span through more cost-effective and non-invasive methods, to enable early and effective intervention on modifiable aging factors. The eye offers a unique window into systemic health, providing direct visualization of the body's vascular and neural health. This review presents an overview of how various ocular structures can serve as biomarkers of health span-drawing on insights from ocular imaging, metabolomics, and proteomics, with evidence from basic science, animal models, …

Mutations In Hsp40 Co-Chaperone Change The Canonical Interdomain Interactions Stimulating Lgmdd1 Myopathy, Ankan K Bhadra, Geetika Aggarwal, Anshuman Jaysingh, Daniel Chen, Jil Daw, Conrad C Weihl, Heather L True

2020-Current year OA Pubs

Limb-girdle muscular dystrophy D1 (LGMDD1) is a rare, dominantly inherited neuromuscular protein-misfolding chaperonopathy caused by mutations in the Hsp40 co-chaperone DNAJB6, primarily in the glycine-phenylalanine (GF) or J-domains. Currently, no treatments are available, and a challenge in understanding the disease is identifying a specific client protein for DNAJB6 in skeletal muscle. DNAJB6 has homology to the yeast DNAJ family member, Sis1. Our previous research indicated that LGMDD1 GF domain mutants in Sis1 exhibit substrate-specific effects, influenced by Hsp70 activity. Herein, we employed functional assays along with advanced molecular simulation studies to understand the regulatory interdomain interactions in disease-causing mutants of …

Phase I Trial Of Adp-A2afp Tcr T-Cell Therapy In Patients With Advanced Hepatocellular Or Gastric Hepatoid Carcinoma, Tim Meyer, Benjamin R Tan, Et Al.

2020-Current year OA Pubs

BACKGROUND & AIMS: Patients with advanced hepatocellular carcinoma (HCC) generally experience poor outcomes despite current therapies, necessitating the development of alternative treatments. ADP-A2AFP is an investigational autologous T-cell therapy with an affinity-enhanced T-cell receptor (TCR) targeting alpha-fetoprotein (AFP).

METHODS: We describe a phase I, open-label, first-in-human clinical trial of ADP-A2AFP (NCT03132792) in human leukocyte antigen-eligible participants with AFP-expressing HCC (or other tumor) not amenable to transplant/resection who progressed on, were intolerant to, or refused prior systemic therapy. Participants received lymphodepletion chemotherapy (cyclophosphamide 500 mg/m

RESULTS: Twenty-one participants, 20 with advanced HCC and one with gastric hepatoid carcinoma received ≥1 ADP-A2AFP …

Cutibacterium Adaptation To Life On Humans Provides A Potential C Acnes Infection Biomarker, Md Shafiuddin, Wen-Chi Huang, Gabriel William Prather, Jeffrey Ryan Anton, Andrew Lawrence Martin, Sydney Brianna Sillart, Jonathan Z Tang, Michael R Vittori, Michael J Prinsen, Jessica Jane Ninneman, Chandrashekhara Manithody, Jeffrey P Henderson, Alexander W Aleem, Ma Xenia Garcia Ilagan, William H Mccoy 4th

2020-Current year OA Pubs

Propionibacteriaceae appear to have adapted to life on humans during the domestication of cattle. These microbial immigrants formed the genus Cutibacterium, and a descendent of those microbial trailblazers (C acnes) now dominates 25% of human skin. C acnes colonization of human skin requires the protein RoxP. Although all Cutibacteria encode this adaptation to life on humans, nothing like RoxP has been found in any other organism. In this study, we report an extensive assessment of 21 RoxP orthologs, which identified conserved molecular surfaces linked to heme-dependent oligomerization and low pH stability. Our investigation suggests how RoxP helps C acnes dominate …

Brain–Computer Interfaces: Opportunities And Challenges, Stephanie Plamondon

Faculty Scholarship

Neurotechnology has entered a period of transformation. Brain–computer interface devices that collect and sometimes influence brain activity, while once confined mainly to research and clinical spheres, are now being marketed to individual and institutional consumers for a range of uses. At the same time, AIdriven data analysis systems are rendering brain activity increasingly comprehensible to machines and humans, presenting the potential for new and improved applications of neurotechnology but also raising privacy concerns. At this exciting juncture, thoughtful attention to the ethical issues surrounding neurotechnology and considered and coordinated policy approaches are warranted to ensure the neurotechnology industry reaches its …

Autotheme: A Multi-Agent Framework For Inductive Thematic Analysis With Llms, Abdullah Wahbeh, Omar El-Gayar, Mohammad Al-Ramahi, Tareq Nasralah, Ahmed Elnoshokaty

Research & Publications

Thematic analysis is a qualitative research method used to identify and interpret patterns in textual data. However, it can be time-consuming and challenging to replicate. While recent advancements in large language models (LLMs) and generative AI have enhanced thematic analysis, existing methods often rely on prompt-based interactions and require significant human intervention. This paper introduces an agentic AI framework comprising autonomous, goal-directed agents powered by LLMs to perform inductive thematic analysis with minimal human input. We evaluate the framework using a dataset from a Cognitive Behavioral Therapy (CBT) mobile app and compare the results with those from Latent Dirichlet Allocation …

Highlighting Ai Competencies: A Qualitative Analysis Approach Using Ai Agents, Ahmed Elnoshokaty, Omar El-Gayar, Abdullah Wahbeh, Mohammad Al-Ramahi, Tareq Nasralah

Research & Publications

The rapid advancement of Artificial Intelligence (AI) is reshaping the job market, creating a demand for new skills and competencies in AI and machine learning (ML). As academic institutions strive to align educational programs with industry needs, a clear understanding of job market expectations becomes essential. This study employs a qualitative, grounded theory approach, enhanced by large language models (LLMs), to analyze job postings related to AI. Using a custom coding framework and AI agent arbitration, we extract and classify the competencies sought by employers into eight major categories. Key findings emphasize the significance of technical skills, including system analysis, …

Project Management For Blockchain: Strategic Guidance And Lessons From Practice., Cherie Noteboom, Aravindh Sekar, Deb Tech

Research & Publications

Blockchain technology (BCT) offers powerful solutions to long-standing enterprise challenges such as inefficiencies, lack of transparency, and low stakeholder trust. By enabling secure transaction tracking and real-time data sharing, BCT can improve operational accuracy, streamline workflows, and build confidence across organizational ecosystems. However, the implementation of BCT significantly transforms conventional project management strategies and practices. We propose practical recommendations for each stage of the process group of the project life cycle- Initiating, Planning, Executing, Monitoring & Controlling, and Closing to meet the demands of decentralization, interoperability, and continuous ecosystem coordination inherent in the implementation of BCT projects. Grounded in practitioner …

Blockchain As A Digital Coordination Infrastructure For Project Management: A Systematic Review And Integrative Framework,, Cherie Noteboom, Sai Neelima Seru, Aravindh Sekar

Research & Publications

Blockchain technology has gained increasing attention as a digital infrastructure capable of improving transparency, trust, and coordination in complex, multi-organizational project environments. However, existing research on blockchain-enabled project management remains fragmented and industry-focused, providing limited guidance for organizational adoption and integration. This study addresses this gap through a systematic literature review of 29 peer-reviewed studies, following PRISMA guidelines, to examine how blockchain capabilities are incorporated into project management practices across industries and maturity stages.

Grounded in Resource-Based View and Coordination Theory, the analysis employs a feature-to-process mapping approach to link six core blockchain capabilities—decentralization, transparency, immutability, smart contracts, traceability, and …

The Datafied Child: A Systematic Literature Review And Research Agenda On Sharenting, Privacy, And Social Media., Kyle Bittle, Cherie Noteboom

Research & Publications

Sharenting, the parental practice of sharing children's personal information online, raises critical privacy, ethical, and regulatory concerns. This systematic literature review and research agenda examines how sharenting is studied, analyzing theoretical frameworks through an information systems (IS) lens. Findings identify five key themes—privacy management, identity presentation, consumer vulnerability, social influence, and parenting ethics—shaped by broader technological, social, and regulatory forces. To structure these insights, this study introduces a three-domain framework to categorize how digital infrastructures, cultural norms, and policy gaps influence sharenting behaviors. The review highlights limited IS engagement in sharenting research and underscores the need for greater focus on …

Decentralizing Work: How Blockchain Reshapes Project Coordination, Trust, And Accountability Through The Strategic-Decentralized Resilience Theory (Sdrt), Aravindh Sekar, Cherie Noteboom

Research & Publications

Blockchain adoption is reshaping how work is organized, coordinated, and governed in project environments. Existing research, however, has largely focused on the methodological and theoretical trends in blockchain-based project management rather than on how blockchain modifies the very structure of work. Building on a systematic literature review of blockchain project management research, this paper draws on the Strategic–Decentralized Resilience Theory (SDRT) as an integrative framework to explain work modification in decentralized project contexts. SDRT captures three interlinked dimensions of resilience: strategic resilience (leadership, alignment, and adaptability), organizational resilience (collaboration, training, and ecosystem readiness), and decentralized resilience (distributed governance, trust, and …

Constructing Information Systems: Technology Frames And Career Interest Among Middle School Students, Cherie Noteboom, Sai Mounika Chintalapudi

Research & Publications

The Information Systems (IS) discipline faces ongoing challenges in attracting students to the field despite its growing societal importance. Previous studies have examined how factors such as gender gaps and STEM identities shape career aspirations; however, there is limited understanding of how early interpretations of the IS discipline shape career interest. This research adapts the TFR (Technology Frames of Reference) theory to examine how middle school students develop understandings of IS. Using qualitative survey data through a deductive approach to identify the Nature of IS, the Purpose of IS, and IS-in-Use, misalignment, and career interest. Misalignment reflects limited knowledge of …

Fragmented Conceptions Of Agency In Ai-Enabled Systems: A Bibliometric Analysis Of Is Research., Cherie Noteboom, Vahini Atluri, Stephen Surles

Research & Publications

As artificial intelligence (AI) systems become increasingly embedded in organizational decision-making and work practices, Information Systems (IS) research has devoted growing attention to questions of agency: who or what acts, decides, and bears responsibility in AI-enabled contexts. However, existing scholarship examines agency across multiple parallel research streams, raising questions about how coherently the construct is theorized as AI technologies evolve. This study conducts a bibliometric analysis of 741 AI- and agency-related articles published between 1977 and 2025 in the AIS Senior Scholars' Basket of Journals to examine how IS research conceptualizes agency and how these conceptualizations have evolved over time. …

Drivers And Barriers To Artificial Intelligence Adoption In Agriculture: A Socio-Technical Analysis Of Midwestern United States Farmers., Abeer F. Alkhwaldi, Cherie Noteboom, Amir A. Abdulmuhsin

Research & Publications

The agricultural industry is at a critical juncture, experiencing global pressures in the form of climate volatility, a shortage of labor, and an increase in production costs. Although artificial intelligence (AI) has the potential for revolution due to its predictive analytics and self-controlled machinery, it has not achieved widespread and even distribution for use, especially among small-to-medium-sized farms in the Midwestern United States. This study formulates and empirically examines a comprehensive socio-technical model to determine the drivers and barriers to the adoption of AI in this agricultural region. Based on a synthesized framework of the “Unified Theory of Acceptance and …

From Ai Ethics To Ethical Misalignment: Understanding Emerging Risks In Agentic Ai Systems, Deb Tech, Aravindh Sekar

Research & Publications

The emergence of Agentic AI systems is reshaping organizational processes through continuous adaptation, autonomous coordination, and real-time operational execution. Unlike traditional artificial intelligence applications focused on discrete decision-making tasks, Agentic AI systems operate continuously and interact dynamically with organizational environments. Existing AI ethics literature has primarily emphasized issues such as fairness, bias, transparency, and accountability within static or decision-centric AI contexts. Similarly, traditional AI alignment research has largely focused on ensuring that AI systems pursue intended goals and remain controllable under specified operational conditions. However, these approaches may be insufficient for explaining how ethical risks evolve with continuously operating autonomous …

How The U.S. Constitution Shapes International Tax Law: Instrument Choice In Tax Agreements, Noam Noked, Young Ran (Christine) Kim, Reuven S. Avi-Yonah

Articles

The U.S. Constitution’s Treaty Clause, which requires Senate approval by a two-thirds vote for treaties, has significantly influenced the development of international tax law. This Article examines the implications of Senate supermajority requirements on bilateral and multilateral tax treaties and agreements, alternative instruments, relevant international tax standards, and global tax governance.

Historically, tax treaties have been approved exclusively as Article II treaties requiring Senate approval. The difficulty of entering into treaties with the United States has influenced the instrument choice and design of U.S. and international tax standards. To address this challenge, several U.S. and international tax reforms have employed …

Trophy Assets, Aneil Kovvali

Articles

Rich people like to own things that make them look cool. When the thing in question is a car, house, or boat, the implications are limited. But sometimes very rich people own assets that are more important. Within media, Elon Musk acquired Twitter, Jeff Bezos ac-quired the Washington Post, and Patrick Soon-Shiong acquired the Los Angeles Times. There has also been a craze for aerospace: Musk with Space X, Bezos with Blue Origin, Richard Branson with Virgin Galactic, and going back further, Howard Hughes with Hughes Aircraft Company. It is often difficult to understand the behavior in purely finan-cial terms, …

Democratizing Restitution: Trust As An Equitable Approach To Competing Claims On Cultural Heritage Objects, Britta Redwood

Articles

As formerly colonized states began to win their independence in the mid-twentieth century, a growing chorus of voices called on museums in London, Paris, Berlin, and other European cities to return objects taken during the colonial period. Having largely ignored these requests until recently, museums throughout Europe and the United States have begun negotiating returns of these objects to their rightful owners. There is a growing recognition among Western cultural institutions that continuing to hold cultural heritage objects taken under conditions of coercion or violence is morally untenable. More recently, some scholars have argued for a human rights approach to …

Regulating Robotaxis, Bryant Walker Smith, Matthew T. Wansley

Articles

In several sunbelt cities, commercial robotaxi service has arrived. The leading robotaxi company is providing over 400,000 trips per week. The industry claims that robotaxis will save lives and provide convenient and affordable mobility. Critics counter that they will increase congestion, undermine transit, and subject the public to ubiquitous surveillance. We argue that the social impact of robotaxis depends on how they are regulated. We emphasize two points missing from the debate. First, some of the benefits of robotaxis may be political rather than technological—some longstanding public policy goals may become viable in a robotaxi world. Second, letting one private …