Digital Commons Network^™

Therapeutic Potential Of Hookworm Proteins In Promoting Regulatory Immune Responses To Modulate Trypanosoma Cruzi Induced Liver Inflammation And Oxidative Stress, Maria Jose Villar, Cristina Poveda, Bin Zhan, Maya Gonsoulin, Kathryn M Jones

Faculty, Staff and Students Publications

Background: Chronic Trypanosoma cruzi infection causes significant liver pathology, and current antiparasitic treatments often worsen hepatic damage. Hookworm-derived proteins have shown immunomodulatory effects in inflammatory diseases, including T. cruzi-induced myocarditis.

Objective: This study evaluates recombinant hookworm proteins AIP-1 and AIP-2 for treating liver inflammation in a murine model of chronic Chagas disease (CD).

Methods: Female BALB/c mice infected with T. cruzi were treated with AIP-1 or AIP-2 (1 mg/kg) for seven days. Controls were untreated or received aspirin (25 mg/kg) for 14 days. Liver tissues were analyzed for parasite burden (quantitative polymerase chain reaction - qPCR), histopathology (H&E, Picrosirius Red), …

Inclusive Psychology Pedagogy Is Linked To Increased Belonging And Reduced Prejudice Toward Consensually Non-Monogamous Relationships, Rose Bern, Rachel Dinero, Kate Linenbach, Amy Moors

Psychology Faculty Articles and Research

Students enrolled in an elective psychology course entitled Relationship Science, which emphasized inclusive curricula focused on relationship diversity, completed pre- and postcourse assessments of attitudes toward consensually nonmonogamous (CNM) relationships, relationship skills (e.g., constructive communication), and classroom belonging. Given the established literature on lesbian, gay, bisexual, transgender, queer+-inclusive pedagogy, attitudes toward lesbian, gay, bisexual, transgender, queer+ individuals were also measured. Comparisons of pre- and postcourse assessments revealed significant reductions in stigma toward individuals engaged in CNM, alongside increased acceptance of CNM relationships more broadly. Students also reported increases in relationship skills and classroom belonging over the course of the …

Empowering Change From The Ground Up: Women’S Entrepreneurship In Sub-Saharan Africa’S Informal Sector, Rita Abban, Esi A. Elliot

International Business and Entrepreneurship Faculty Publications

Women’s entrepreneurship in Sub-Saharan Africa (SSA) is a critical driver of socio-economic development, within the informal sector where women enterprises are concentrated. Despite substantial contributions, structural and institutional barriers impede the formalization of these businesses, curbing their economic impact. This study examines how women entrepreneurs in Ghana and SSA navigate informal practices to achieve economic mobility. Employing a systematic literature review - PRISMA framework, the research synthesizes key themes including entrepreneurial capacity, sustainability, intellectual property, and institutional support. A comparative lens incorporating Rwanda and South Africa reveals Ghana’s high rate of female entrepreneurship, predominance of informal trade, and socio-cultural dynamics …

A Firm’S Operational Risk: Data Set And Empirical Evidence, Vivek Astvansh, Joseph J. Simpson

International Business and Entrepreneurship Faculty Publications

Problem definition: A firm’s stakeholders would benefit from a quantitative measure of the managerial disclosure of its operational risk and the implications of this disclosure. However, a quantitative and scalable measure of a firm’s disclosed operational risk is unavailable. Thus, the firm’s stakeholders remain unaware of its disclosed operational risk and the risk’s implications. Methodology/results: U.S. law requires a public firm to textually disclose its operational and nonoperational risks in Item 1A of its annual report (i.e., Form 10-K). We train 64 transformer models on U.S. public firms’ Item 1A text to score 131,920 firm-years (16,959 firms, 2005 to 2024) …

Making Words Count: Computational Linguistics In Management Research, Joseph J. Simpson, Richard A. Hunt, David M. Townsend, Judy Rady, Elham Asgari, Mohammad Rady, Daniel J. Beal

International Business and Entrepreneurship Faculty Publications

In recent years, a rapidly growing number of management scholars are using computational linguistics (CL) to analyze vast corpora of naturally occurring organizational language. Yet the rapid adoption of CL methods has outpaced the development of shared standards for linking theoretical constructs, linguistic data, and computational measurement. We synthesize 353 articles published in leading management journals for 2013–2025, identifying four recurring challenges shaping the credibility of CL-based research: misalignment between constructs and textual corpora, unnecessary model complexity, the opacity of large language model workflows, and insufficient transparency in reporting. Building on these patterns, we develop four integrative design principles—construct-language fit, …

Beyond Exposure: Belief In Police Misinformation, Media Consumption, And Support For Policing Reform, Linda Balcarova Dietz

Electronic Theses & Dissertations (2024 - present)

In today’s post-truth era, misinformation has become a central feature of modern society. While not a new phenomenon, the 2024 Presidential election demonstrated what a serious problem it represents, as public perceptions were driven more by information they received (true or false) than by objective social conditions. Policing is one of the most debated topics in criminal justice, dividing public opinion along partisan and racial lines. Studies show that the information people receive about police shapes their attitudes, yet criminologists have largely overlooked how misinformation may influence those views. This dissertation fills that gap by experimentally testing how exposure to …

Platelet Extravasation In The Microvasculature: An Under-Appreciated Role For Platelets, Justin A Courson, Vahid Afshar-Kharghan, Alan R Burns, Rolando E Rumbaut

Faculty, Staff and Students Publications

In recent years, evidence has accumulated highlighting the presence and role of platelet extravasation - wherein platelets accumulate in tissue parenchyma - at a variety of sites throughout the body. While platelets are traditionally known for their roles in hemostasis and thrombosis, it is evident that platelets are potent mediators of inflammation across an array of physiological and pathological contexts. While anucleate and small in size, platelets contain a rich diversity of molecules in their granules capable of modulating cell proliferation, tissue repair, and a host of immune responses. There is growing evidence that platelet extravasation out of the vascular …

Using Medication Pass Analysis To Examine Longitudinal Changes In Va Inpatient Nurse Staffing And Workload Before And Through The Covid-19 Pandemic: 2019-2022, Melissa K Knox, Chase S Eck, Lynette Dorsey, Paras D Mehta, Christine Yang, Laura A Petersen

Faculty, Staff and Students Publications

Background: The COVID-19 pandemic resulted in extended disruption to the health care system. National-level data-driven comparisons of inpatient nurse staffing and workload before and during the pandemic have been limited.

Objectives: Assess the extent to which registered nurse (RN) staffing and workload changed from prepandemic levels in a national integrated health care system.

Research design: Longitudinal descriptive analysis. Medication pass analysis using bar code medication administration data for the peak-time medication pass (PTM) assessing year-over-year changes from 2019 to 2022. To assess significance of year-over-year changes in means we used the Welch 2-sample t test.

Subjects: Staff (N=42,999) administering PTM …

Ptpn1 Regulation Via Ybx1-Ptbp1 Interaction Promotes Fibroblast Activation And Fibrotic Remodeling In The Lung, Huibing Liu, Cong Xia, Yingying Zhang, Yulong Gan, Lianhui Cheng, Xuqian Wang, Airu Chang, Wenyu Zhao, Bin Li, Yaxuan Wang, Yajun Li, Ivan Rosas, Juntang Yang, Guoying Yu, Lan Wang

Faculty, Staff and Students Publications

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial pneumonia of unknown etiology. Its pathogenesis involves complex multicellular interactions and signaling pathways, with fibroblast-to-myofibroblast transition (FMT) being critical for fibrogenesis. Although the transcription factor Y-box binding protein 1 (YBX1) regulates processes such as cell proliferation, transcription, translation, and DNA repair, its role in IPF remains undefined. Here, we demonstrate that YBX1 overexpression significantly promotes transforming growth factor-β1 (TGF-β1)-induced pulmonary FMT, leading to substantially increased extracellular matrix (ECM) deposition in primary human (PHLFs) and mouse (PMLFs) lung fibroblasts. Conversely, YBX1 inhibition markedly suppresses TGF-β1-driven aberrant fibroblast migration and activation. Mechanistically, YBX1 …

Falling For Mobility, Wendy Savercool Dnp, Rn, Crni, Ocn, Fab, Ian Heck Msn, Rn, Nea-Bc, Kayla Rosica Msn, Rn, Ne-Bc, Medsurg-Bc

Patient Care Services / Nursing

No abstract provided.

Helping Nurses To ‘Get Their Good Work Out There’, Lori Grischott Msn, Rn, Nea-Bc, Npd-Bc, Rnc-Ob, Lauren Souchak Msn, Rn, Bea-Bc

Patient Care Services / Nursing

No abstract provided.

Immune-Mediated Diarrhea And Colitis With Normal Biochemical, Endoscopic And Histologic Findings: A Retrospective Study, Malek Shatila, Sharada Wali, Carolina Colli Cruz, Kei Takigawa, Andres Caleb Urias Rivera, Kian Abdul-Baki, Tanvi Gupta, Elliot Baerman, Linfeng Lu, Irene Jeong-Ah Lee, Raakhi Menon, Hamza Salim, Andrew Sullivan, Varun Vemulapalli, Cristina Natha, Ayesha Khan, Krishnavathana Varatharajalu, Stephane Champiat, Kerry L Reynolds, Lucy B Kennedy, Katy Tsai, Anusha Shirwaiker Thomas, Yinghong Wang

Faculty, Staff and Students Publications

Background: Immune-mediated diarrhea and colitis (IMDC) due to checkpoint inhibition infrequently presents with normal stool biomarkers and no endoscopic or histologic evidence of inflammation. Little is known about the treatment needs and outcomes of this subset of patients. We aimed to describe this entity and clarify the role of immunosuppressive treatments in its management.

Method: This was a single-center, retrospective study of patients treated with immune checkpoint inhibitors who developed clinical symptoms of IMDC, with no evidence of inflammation based on fecal calprotectin or endoscopic/histologic evaluation, between January 2010 and February 2024.

Results: Of 1151 patients with IMDC, 131 (11.4%) …

Interdisciplinary Swiss Consensus Recommendations For Follow-Up After Radical Cystectomy And Trimodal Treatment For Muscle-Invasive Bladder Cancer, Ernest Kaufmann, Stefanie Aeppli, Andres Affentranger, Nicolas Arnold, Winfried Arnold, Fabian Aschwanden, Panagiotis Balermpas, Jörg Beyer, Uwe Bieri, Joost Boormanns, Richard Cathomas, Berardino De Bari, Marco Dressler, Daniel S Engeler, Andreas Erdmann, Andrea Gallina, Silvia Gomez, Matthias Guckenberger, Thomas Herrmann, Thomas Hermanns, Ilaria Lucca, Hubert John, Thomas Matthias Kessler, Jan Klein, Mohamed Laouiti, David Lauffer, Seth Paul Lerner, Agostino Mattei, Michael Müntener, Daniel Nguyen, Philipp Niederberger, Alexandros Papachristofilou, Lukas Prause, Paul Martin Putora, Karsten Reinhardt, Emanuela Salati, Philippe Sèbe, Mohamed Shelan, Silvan Sigg, Räto Thomas Strebel, Arnoud Jan Templeton, Ursula Vogl, Marian Severin Wettstein, Stephen Wyler, Deborah Zihler, Thomas Zilli, Daniel Zwahlen, Beat Roth, Christian Daniel Fankhauser

Faculty, Staff and Students Publications

Introduction: Radical cystectomy or trimodal therapy are treatment options for non-metastatic bladder cancer. However, there is limited evidence guiding post-treatment follow-up regimens, resulting in variations in care.

Objective: A Swiss consensus meeting aimed to identify gaps in follow-up strategies and subsequently tailoring follow-up protocols after curative treatment for bladder cancer.

Methods: A consensus meeting including participants from urology, oncology, radiation oncology, neuro-urology, international advisors, and patient representatives was held. 19 pre-formulated questions addressing follow-up duration, frequency, and modalities after radical cystectomy or trimodal therapy for bladder cancer were discussed and voted by participants.

Results: 42 experts from 22 institutions participated …

Commencement Program 2026, Loma Linda University

Commencement Programs

CONTENTS

1 | Message from the President

3 | 2026 Events of Commencement

5 | The Academic Procession

6 | Institutional Administration

7 | Board of Trustees

8 | Significance of Academic Regalia

9 | University History Highlights

11 | Loma Linda University Health and Loma Linda University Honorees

The Programs, The School Honorees, and The Speakers

24 | School of Medicine

43 | School of Pharmacy

54 | School of Dentistry

72 | School of Public Health

85 | San Manuel Gateway College

91 | School of Allied Health Professions — Allied Health Studies, Cardiopulmonary Sciences, Clinical Laboratory Science, …

Elementary Teachers' Perceptions On Mtss, Inclusion And Instructional Pedagogy, Sarah Mccusker

All Capstone Projects

The purpose of the study was to examine elementary teachers’ perceptions of the multi-tiered system of support (MTSS) implementation process, their understandings of inclusion, and the ways these beliefs informed their pedagogy. To gain deeper insight into these dynamics, a phenomenological approach was employed, in which elementary educators were invited to participate in interviews that focused on the MTSS process in their school contexts. Findings revealed teachers’ interpretations of inclusive classrooms, their perceptions of MTSS frameworks, and the strategies they used to address students’ academic and behavioral needs while recognizing individual strengths. Teachers shared their beliefs about students who do …

Non-Congenital Hsv-1 Keratitis In An Immunocompetent 9-Month-Old Infant, Caleb A Casanova, Stephanie Trejo Corona, Stephen F Pflugfelder

Faculty, Staff and Students Publications

Isolated, non-congenital herpes simplex virus type 1 (HSV-1) keratitis in immunocompetent infants is exceedingly rare and may be easily misdiagnosed, leading to delays in appropriate antiviral therapy. This case is unique in that it describes HSV-1 keratitis in a healthy 9-month-old infant presenting without systemic illness, initially treated as bacterial conjunctivitis. The patient presented with unilateral eye pain, redness, and corneal opacification. Subsequent evaluation revealed HSV-1 keratitis, and the patient was treated with intravenous acyclovir in combination with topical moxifloxacin and topical ganciclovir, resulting in complete resolution of symptoms within one week. This case adds to the limited literature on …

Point-Of-Care Ultrasound Foundations In Physics And Image Acquisition: An Innovative Hands-On Active Learning Workshop, Cherie Tator, Saul Flores, Alan Riley, Kiyetta Alade

Faculty, Staff and Students Publications

Introduction: We developed an innovative, active learning workshop to introduce foundations of point-of-care ultrasound (POCUS) physics and instrumentation. The workshop design aimed to reduce cognitive load and encourage learner-centered engagement through hands-on exploration that reinforces key principles and connects theory to practice.

Methods: First-year medical students participated in small-group, student-driven exercises to explore POCUS machine controls, transducers, and image acquisition skills. Each group was supported by a faculty member to guide activities and ensure accuracy. Students scanned pickles, hard-boiled eggs, and olives with pits; these items were selected for their low cost, sonographic characteristics, and recognizability. Later in the semester, …

The Impact Of Sports Betting Legalization On Marital Status, Hosea Gitonga Njogu

Theses and Dissertations

This study examines the causal Impact of sports gambling legalization on marital stability in the United States using data from the Current Population Survey Annual Social and Economic Supplement (CPS-ASEC) and the American Community Survey (ACS) from 2013 to 2024. The analysis leverages variation in the staggered adoption of state-level sports gambling laws and applies two-way fixed effects, event-study, and the Callaway and Sant’Anna (2021) difference-in-differences estimators, controlling for geographic and individual characteristics. Legalization increases divorce rates by 0.42 percentage points in the CPS and 0.51 percentage points in the ACS, corresponding to increases of 2.4% and 2.6%, or approximately …

Managing Multi-Drug Resistance: An Evolutionary Game Theory And Optimal Control Approach, Shukhrat Nasrulloev

Theses and Dissertations

Multi-drug resistance is an evolutionary process in which treatment eliminates sensitive cells, allowing resistant clones to dominate. This thesis investigates this process using a framework integrating population dynamics, evolutionary game theory, and optimal control theory. We develop a two-population logistic growth model describing competition between drug-sensitive and drug-resistant cells under treatment, construct dose-dependent payoff matrices and replicator dynamics to characterize evolutionary competition, and derive a critical drug level D_crit = (r_S - rR)/(dS - d_R) at which resistant cells gain a fitness advantage. An optimal control problem is formulated via Pontryagin's Maximum Principle to identify schedules …

Perceived Barriers To Physical Activity And Campus Recreation Facility Usage In College Students Referred Or Not Referred To An Exercise Is Medicine® On Campus Program, Benjamin M. Colbert

Theses and Dissertations

INTRODUCTION: Approximately 36-50% of college students are inactive and report numerous barriers to being physically active. Physical activity (PA) barriers are any obstacle an individual believes affects their PA participation. Individuals who perceive more barriers are less likely to participate in PA and as such, interventions that target barriers may increase PA participation. Exercise is Medicine^® on Campus (EIM-OC) is one intervention that may improve PA levels on college campuses by reducing barriers. The purpose of this study was to document PA and campus recreation facility barriers in university students and examine the influence of an individualized EIM-OC intervention …

Informing Policies: Examining Socio-Cultural Factors Influencing The Prevalence Of Gender-Based Violence, Patricia M. Ebubechukwu

Theses and Dissertations

Despite growing policy attention and legal reforms, Intimate partner violence (IPV) remains a persistent public health and human rights concern in Nigeria. This study examines the socio-cultural influences on the prevalence of gender-based violence among ever-married women in Nigeria using data from the 2024 Nigeria Demographic and Health Survey (NDHS). Drawing on a nationally representative sample of 19,863 women aged 15 to 49, the research investigates how geopolitical zone, internalized gender norms, religious affiliation, educational attainment, and household wealth shape women’s experiences of physical, sexual, and emotional IPV. Guided by social norms theory and the ecological model of violence, the …

Elite Cues Vs. Economic Vulnerabilities: What Explains Isolationist Foreign Policy Attitudes Among Americans?, Sabyasachi Karmaker

Theses and Dissertations

This thesis examines whether contemporary isolationist foreign policy attitudes among Americans are better explained by elite political cues or by economic vulnerabilities. Using data from the 2024 American National Election Study (ANES), the study also examines which mechanism holds more explanatory power in shaping isolationist views. The findings show that both elite cues and economic vulnerabilities are associated with isolationist attitudes, but elite cues have greater explanatory power. These results suggest that contemporary American isolationism is more strongly associated with political identity and elite messaging than with economic hardship alone.

Fuchs' Problem For Quasi-Cyclic Groups, Dalen F. Elliott

Theses and Dissertations

Fuchs’ problem asks which groups can arise as the group of units of a ring. Although the finite cyclic case has been completely classified, much less is known in the infinite setting. This thesis contributes to this problem by investigating quasi-cyclic. (Pr¨ufer) groups and their finite direct products. We show that for every odd prime p, there is no commutative ring R such that R×∼= Cp∞. This obstruction arises from characteristic restrictions and the algebraic structure of finite fields. More generally, we prove that any group in which every element has order a power of an odd prime p and …

Building Resilience And Academic Belonging Through An Educational Intervention For Latine Families, Britney Ramos

Theses and Dissertations

Latine students continue to experience disparities in college persistence and completion despite the growing rate of enrollment in higher education. Previous research has focused on the importance of family involvement, culturally responsive programming, and the sense of belonging for Latine students. However, continued research is needed to better understand how family-centered programs support both Latine youths’ sense of belonging and their perceived preparedness for college. This study focuses on how participation in the Juntos Para Una Mejor Educación program relates to Latine youths’ sense of belonging and perceived preparedness for college, as well as how family expectations shape these outcomes. …

Thinking Machines: Cybernetics, Artificial Intelligence, And Technological Anxiety In The American Cold War, Erin Mae Wilcox

Theses and Dissertations

Following the Second World War, cybernetics emerged as a cross-disciplinary study in philosophy, neurophysiology, electrical engineering, and mathematics. Cyberneticists proposed the formal study of the man-machine analogy; that is, to equate biological structures to a complex mechanical system. Drawing from this analogy, cyberneticists used programmable digital computers to emulate the functions of the human brain. The study of artificial intelligence emerged within this cybernetic discourse in the early 1950s; yet, by the mid-1960s, the two disciplines suffered a methodological fracture. Drawing from a tradition generated by this fracture, historians have traditionally examined cybernetics and artificial intelligence in isolation from one …

Cover Crop Effects On Soil Porewater Nutrients And Hydrothermal Properties, Md Mahadi Hasan

Theses and Dissertations

Adoption of winter cover crops in the U.S. Midwest may reduce nitrogen (N) and phosphorus (P) leaching from soils, potentially shrinking the hypoxic zone by limiting nutrient runoff into the Gulf of Mexico. To evaluate the impact of selected winter cover crops on soil porewater N and P concentration, a field study was conducted at the Illinois State University Research Farm (ISURF) and the Western Illinois University Research Farm (WIURF). The experimental design was a block experiment with four replications.  Cover crop treatments included a winter fallow, wild pennycress (WPC), golden pennycress (GPC), cereal rye (CR), annual ryegrass (AR), and …

Framing Belonging And Exclusion: A Dialogic Narrative Analysis Of English- And Spanish-Language Immigration Coverage During The Trump 2024 Presidential Election, Evangeline T. Cruz

Theses and Dissertations

I investigated how English- and Spanish-language news outlets narratively constructed Latinx immigrants during the Trump 2024 presidential campaign, a period marked by heightened anti-immigrant rhetoric and political volatility. While past scholarships examined immigration framing through tone, sentiment, or frequency analysis, limited attention has been given to the deeper narrative structures that shape public meaning-making. This study addresses this gap by applying Dialogic Narrative Analysis (DNA) and Critical Thematic Analysis (CTA) to a bilingual dataset of 120 newspaper articles from The New York Times, Los Angeles Times, El Diario, and La Opinión published between November 2024 and February 2025.

Findings reveal …

Data Defines Success: Algorithm For Dataset Quality Assessment In Deep Learning For Malware Detection, Matei Ionescu

Theses and Dissertations

The field of artificial intelligence is based upon the premise of constructing architectures through which to propagate training data. However, the majority of existing research literature is focused on architecture. While necessary, the attention devoted to the architecture should not so precipitously exceed that of the data. It should be noted that this disparity is not without reasonable cause. Data quality is often exceedingly difficult to verify due to particularities of the field or subfield; LLM repositories of text are distinct from image recognition pictures of dog breeds which are distinct from EEG waveforms of human brains which are distinct …

Secret-Keeping Experiences Of Young Adults, Jace C. Griffith

Theses and Dissertations

In 2020, researchers Frijns et al. called for a new wave of secret-keeping research which prioritized the person-centric experience of youth keeping secrets. This study added to that collection by comparing two kinds of secret-keeping which are not compared in existing research: secrets which are related to abuse, and secrets which are not. Researchers in the field of child welfare study only abuse-related secret-keeping, almost always qualitatively. Alternatively, researchers of non-abuse secret-keeping or general secret-keeping collect almost entirely quantitative data, absent of the personal experience of secret-keeping.

Through an online survey, 205 undergraduate students were asked to reflect on an …

From Deference To Dialogue: How International Gtas From High Power Distance Cultures Adapt To U.S. Classroom Dynamics, Deborah Akua Afi Appiah

Theses and Dissertations

International graduate teaching assistants (GTAs) from high power distance cultures play a significant role in undergraduate education at U.S. universities, yet they face challenges that go well beyond language proficiency. Coming from educational backgrounds where teacher authority is unquestioned and hierarchical, these GTAs must navigate American classrooms that operate on fundamentally different assumptions, where authority is earned rather than assumed, informality is the norm, and students expect to question, negotiate, and be personally known by their instructors. The present study examined how eighteen (18) international GTAs from seven (7) high power distance countries perceived and adapted to these differences while …