Digital Commons Network^™

Δnp63 Defines An Exocrine-Committed Subset Of Murine Pancreatic Progenitor Cells, Katarina Coolens, Melissa Van Der Vliet, Jente Van Campenhout, Natalia Del Pozo, Alejo Torres-Cano, Catharina Olsen, Jianming Xu, Rose-Anne Romano, Heiko Lickert, Meritxell Rovira, Isabelle Houbracken, Jonathan Baldan, Francisco X Real, Francesca M Spagnoli, Ilse Rooman

Faculty, Staff and Students Publications

No abstract provided.

Once-Weekly Navepegritide In Children With Achondroplasia: The Approach Randomized Clinical Trial, Ravi Savarirayan, Ciara Mcdonnell, Carlos A Bacino, Daniel G Hoernschemeyer, Janet M Legare, M Jennifer Abuzzahab, Paul L Hofman, Philippe M Campeau, Josep Maria De Bergua Domingo, Leanne M Ward, Kevin Smit, Alden Smith, Meng Mao, Michael S Ominsky, Lærke C Freiberg, Aimee D Shu, Hanne B Hove

Faculty, Staff and Students Publications

Importance: Historically considered a skeletal dysplasia characterized by disproportionate short stature, achondroplasia is a condition with multisystemic effects due to the widespread expression of the fibroblast growth factor receptor 3 variant throughout the body, impacting muscle, neurological function, cardiorespiratory health, and health-related quality of life.

Objective: To evaluate the efficacy, safety, and tolerability of once-weekly navepegritide, an investigational prodrug of C-type natriuretic peptide, while assessing benefits beyond growth that may have important implications for complications and health-related quality of life in children with achondroplasia.

Design, setting, and participants: Enrollment for this pivotal phase 2b, randomized, double-blind, placebo-controlled trial (APPROACH) was …

Acmg Medical Directors’ Special Interest Group Survey: Current Challenges For Medical Genetics Clinics, Mark Dulchavsky, Catherine E Keegan, Nathaniel H Robin, Chad Haldeman-Englert, Shweta U Dhar, Fuki M Hisama

Faculty, Staff and Students Publications

Purpose: The American College of Medical Genetics and Genomics Medical Directors' Special Interest Group (SIG) began in 2021 as a forum for directors of medical genetics clinical groups to share questions, concerns, current practices, and solutions regarding clinical operations. We report on the first 4 years of the SIG-its membership growth and SIG activities. We also present quantitative and qualitative results of a nationwide survey of 66 SIG members addressing recurrent questions from members regarding: wait times, volume of referrals, clinical workload expectations, and independent practice of genetic counselors (GCs) and advanced practice providers.

Methods: Cross-sectional survey of American College …

Correction: Establishing Standardized Transthoracic Echocardiography Reference Ranges For Mouse Models: Insights Into The Impact Of Anesthesia, Sex, And Age, Manuela A Oestereicher, Christopher S Ward, Elida Schneltzer, Susan Marschall, Helmut Fuchs, Valerie Gailus-Durner, Ghina Bou About, Mohammed Selloum, Hamid Meziane, Michelle Stewart, Lydia Teboul, Clare Norris, Dale Pimm, Marina Kan, Federico López Gómez, Robert Wilson, Mayra Monroy, Sheraz Pasha, Eva Zabrodska, Jan Prochazka, David Pajuelo Reguera, Zuzana Nichtova, Yann Herault, Sara Wells, Helen Parkinson, Jason D Heaney, Radislav Sedlacek, Xiang Gao, Martin Hrabe De Angelis, Nadine Spielmann

Faculty, Staff and Students Publications

This corrects the article "Establishing standardized transthoracic echocardiography reference ranges for mouse models: insights into the impact of anesthesia, sex, and age" in volume 12, 1695034.

Cultured Ex Vivo Human Brain Tissue Maintains Cell-Type Transcriptional Identities, J P Mcginnis, Sai Mallannagari, Maria Camila Guevara, Joshua Ortiz-Guzman, Benjamin D W Belfort, Suyang Bao, Snigdha Srivastava, Maria Morkas, Emily Ji, Kalman A Katlowitz, Angela Addison, Evelyne K Tantry, Carrie A Mohila, Melissa M Blessing, Nisha Gadgil, Samuel G Mcclugage, David F Bauer, William E Whitehead, Guillermo Aldave, Omar Tanweer, Naser Jaleel, Ali Jalali, Akash J Patel, Sameer A Sheth, Howard L Weiner, Shankar Gopinath, Ganesh Rao, Akdes Serin Harmanci, Daniel Curry, Benjamin R Arenkiel

Faculty, Staff and Students Publications

There is growing recognition of the need for human-based models of the nervous system and its diseases. Studies have investigated the electrophysiological properties of neurons in ex vivo human brain tissue, but the maintenance of other cell types remains unclear. We therefore used single-nucleus RNA sequencing of six patient samples to determine how well various cell types maintain their transcriptional identities over two weeks in organotypic slice culture (day 0, with 83 501 nuclei, and day 14, with 45 738). For each patient sample (two pediatric temporal lobectomies, one adult frontal cortex, two glioblastomas, and one medulloblastoma), we generated correlations …

Conventional Versus Advanced Imaging Selection For Endovascular Treatment Of Basilar Artery Occlusion Strokes, Huanwen Chen, Marco Colasurdo, Hidetoshi Matsukawa, Conor Cunningham, Ilko Maier, Sami Al Kasab, Pascal Jabbour, Joon-Tae Kim, Stacey Quintero Wolfe, Ansaar Rai, Robert M Starke, Marios-Nikos Psychogios, Edgar A Samaniego, Nitin Goyal, Shinichi Yoshimura, Hugo Cuellar, Jonathan A Grossberg, Ali Alawieh, Ali Alaraj, Mohamad Ezzeldin, Daniele G Romano, Omar Tanweer, Justin Mascitelli, Isabel Fragata, Adam Polifka, Fazeel Siddiqui, Joshua Osbun, Roberto Crosa, Charles Matouk, Min S Park, Michael R Levitt, Waleed Brinjikji, Mark Moss, Travis Dumont, Ergun Daglioglu, Richard Williamson, Pedro Navia, Reade De Leacy, Shakeel Chowdhry, David J Altschul, Alejandro M Spiotta, Peter Kan

Faculty, Staff and Students Publications

Introduction: Endovascular thrombectomy (EVT) is an effective treatment for basilar artery occlusion (BAO) stroke in select patients. While there is a growing body of literature suggesting that advanced imaging modalities such as computed tomography perfusion (CTP) and magnetic resonance (MR) may not be necessary for selecting anterior circulation large vessel occlusion stroke patients for EVT, whether advanced imaging may be superior to conventional imaging (non-contrast CT and CT angiography) in identifying good treatment candidates among BAO patients is less clear.

Patients and methods: This was a multicenter retrospective cohort study of BAO EVT patients treated from 2013 to 2022 in …

Mapping The Structural Connections Between The Anterior Cingulate Cortex And The Insula/Ventrolateral Prefrontal Cortex.Mapping The Structural Connections Between The Anterior Cingulate Cortex And The Insula/Ventrolateral Prefrontal Cortex, Wei Tang, Javier Guaje, Shreyas Fadnavis, Sarah R Heilbronner, Eleftherios Garyfallidis

Faculty, Staff and Students Publications

The anterior cingulate cortex (ACC) is functionally closely related with the insula and the ventral lateral prefrontal cortex (vlPFC). The ACC and insula are the main hubs of the salience network, a set of functionally related brain regions involved in detecting salient stimuli and coordinating inter-network communication, while communication between ACC and vlPFC is closely linked to inhibitory control. However, despite strong indirect evidence from nonhuman primate (NHP) tract tracing, the structural connections between the ACC and the insula/vlPFC remain poorly understood in the human brain, in part because standard approaches fail to capture this projection. In this study, we …

Old Lesions And New Targets: Seeg-Identified Onsets In Traditionally Inoperable Epilepsy Lesions And Associated Surgical Outcomes, Yosef M Dastagirzada, Spencer Frome, Daniel J Curry, Howard L Weiner

Faculty, Staff and Students Publications

Background: Patients with epilepsy who do not respond to pharmacotherapy are often offered a noninvasive diagnostic workup to localize an epileptogenic focus that might be treated with resection, neuromodulation, or ablation. Yet in many cases, this evaluation fails to identify surgical candidates.

Summary: Patients with tuberous sclerosis, periventricular nodular heterotopia, or polymicrogyria may have clearly visible lesions on MRI, but the resulting epileptogenic onset zones/networks are often too complex for scalp electroencephalography to decode. Similarly, seizures arising from the cingulate gyrus originate in deep structures that are inaccessible to noninvasive techniques. In post-traumatic epilepsy without a dominant lesion such as …

The Role Of Hospitality In Neurosurgery, Yosef M Dastagirzada, Howard L Weiner

Faculty, Staff and Students Publications

Background: "Business, like life, is all about how you make people feel. It's that simple and it's that hard" says Danny Meyer, the restauranteur and CEO of the Union Square Hospitality Group in New York. Similarly, Maya Angelou famously said that people will never forget how you made them feel, though they may forget what you said or did. In neurosurgery, we are doing two things at once: something very technical and something very human. The core thesis of this hospitality philosophy is that whereas the technical aspect of our job is critically important, it represents 49% of our success. …

Hemispherotomy For Drug-Resistant Epilepsy In A Low-Resource Setting: Surgical Outcomes And Quality Of Life In 23 Children Treated In A Hybrid Program In Panama, Emmajane G Rhodenhiser, David Bonda, Carmen Baez, Hannah K Weiss, Yosef Dastagirzada, Guzman Aranda, Laurent Bruggeman, Ameeta Grover, Shaun D Rodgers, Ruben Kuzniecky, Yvonne Zelenka-Kuzniecky, Howard L Weiner, Eveline Teresa Hidalgo

Faculty, Staff and Students Publications

Introduction: Hemispherotomy is an effective treatment for children with drug-resistant epilepsy (DRE). While hemispherotomy techniques and indications have evolved, access remains predominantly constrained to high-resource settings.

Methods: We performed a retrospective analysis of children who underwent hemispherotomy from 2011 to 2023 by a hybrid team, including local Panamanian and US neurologists, neurosurgeons, and EEG technicians and analyzed surgical, epilepsy, and quality of life (QoL) parameters. Follow-up data were collected according to the International Consortium for Health Outcomes Measurement (ICHOM) guidelines for children with epilepsy.

Results: Twenty-three children underwent hemispherotomy. The median age at surgery was 10 years (range 2-20). The …

Comparative Outcomes Of Robotic Single-Port Vnotes Versus Robotic-Xi Assisted Single-Incision Transumbilical Surgery For Hysterectomy, Qiannan Yang, David Pasternak, Chunhua Zhang, Xiaoming Guan

Faculty, Staff and Students Publications

Introduction: This study was to evaluate the safety and feasibility of robotic single-port transvaginal natural orifice transluminal endoscopic surgery (RSP-vNOTES) compared with robotic Xi-assisted single-incision transumbilical surgery (RXi-SITS) for hysterectomy.

Method: A total of 405 patients was retrospectively analyzed, comprising 278 individuals who underwent RXi-SITS hysterectomy and 127 who underwent RSP-vNOTES hysterectomy.

Results: A significantly higher prevalence of endometriosis-associated concomitant procedures, including ovarian cystectomy, lesion excision, adhesiolysis, appendectomy, bowel shaving, and bowel oversew, was observed among patients undergoing RSP-vNOTES (all p < 0.05). The RXi-SITS group saw uterosacral ligament suspension and ovarian vein ligation more commonly performed (both p < 0.05). A multivariable linear regression approach was employed to account for heterogeneity in procedural complexity. Following multivariable adjustment, estimated blood loss, hysterectomy time, and postoperative pain outcomes were comparable between the two surgical approaches. In contrast, multivariable linear regression accounting for concomitant procedures demonstrated that the RXi-SITS approach was independently associated with a significantly prolonged total operative time, with an adjusted mean increase of 21.8 min compared with RSP-vNOTES (B = 21.83; 95% CI: 6.05-37.61; p = 0.007). This is despite unadjusted analyses showing a longer median operative time in the RSP-vNOTES group …

Disrupted Intrathalamic And Thalamocortical Structural Covariance Networks In Posttraumatic Stress Disorder, Nick Steele, Ahmed Hussain, Delin Sun, C Lexi Baird, Courtney Russell, Neda Jahanshad, Lauren E Salminen, Miranda Olff, Jessie L Frijling, Dick J Veltman, Saskia B J Koch, Laura Nawijn, Mirjam Van Zuiden, Li Wang, Ye Zhu, Gen Li, Dan J Stein, Jonathan Ipser, Sheri Koopowitz, Yuval Neria, Xi Zhu, Orren Ravid, Sigal Zilcha-Mano, Amit Lazarov, Benjamin Suarez-Jimenez, Ashley A Huggins, Jennifer Stevens, Kerry Ressler, Tanja Jovanovic, Sanne J H Van Rooij, Negar Fani, Emily L Dennis, David F Tate, David X Cifu, William C Walker, Elisabeth A Wilde, Ivan Rektor, Pavel Říha, Milissa L Kaufman, Lauren A M Lebois, Justin T Baker, Anthony King, Israel Liberzon, Mike Angstadt, Nicholas D Davenport, Seth G Disner, Scott R Sponheim, Thomas Straube, David Hofmann, Guang Ming Lu, Rongfeng Qi, Amit Etkin, Adi Maron-Katz, Xin Wang, Austin Kunch, Hong Xie, Yann Quidé, Wissam El-Hage, Shmuel Lissek, Hannah Berg, Steven E Bruce, Josh Cisler, Marisa Ross, Ryan Herringa, Daniel W Grupe, Jack B Nitschke, Richard J Davidson, Christine Larson, Terri A Deroon-Cassini, Carissa W Tomas, Jacklynn M Fitzgerald, Brandee Feola, Jennifer U Blackford, Bunmi O Olatunji, Geoffrey May, Steven M Nelson, Evan M Gordon, Chadi G Abdallah, Ruth Lanius, Maria Densmore, Jean Théberge, Richard W J Neufeld, Paul M Thompson, Rajendra A Morey

Faculty, Staff and Students Publications

The thalamus is a heterogeneous structure crucial for corticocortical communication, affective–perceptual integration, motor preparation, and memory-related functions. Posttraumatic stress disorder (PTSD) is characterized by various symptoms that likely relate to thalamic functions. Group-level and individual differential structural covariance (SC) analyses were conducted on intrathalamic, thalamocortical, and thalamosubcortical volumetric networks by segmenting structural MRI data from 2,784 subjects (PTSD n = 1,306; controls n = 1,478) into 25 thalamic nuclei per hemisphere. We found that PTSD was associated with stronger intrathalamic and thalamocortical network strength and stronger SC between the limbic thalamus and the somatomotor and auditory thalamus. PTSD severity was …

The Ideological Work Of Penal Reform: How Reformers Justify Penal-Welfare Hybridization, John Halushka, Brandon Miller

Faculty Research, Scholarly, and Creative Activity

This article uses the Santa Clara County Reentry Resource Center (RRC) as a case study to explore the cultural content of penal reform. Specifically, we explore the discourses that officials use to publicly justify projects of penal-welfare hybridization, or the linking of state systems of punishment and welfare to manage criminalized populations. Our qualitative analysis draws on a dataset consisting of county planning documents, budgets, videos, press releases, and newsletters published online between 2011 and 2023. By examining these materials over time, we are able to chart patterns of consistency and variation in how officials justify hybridization. We find that …

The Energy Change Of Graphs Under Some Edges Deletions, Huan Lei Shi, Wen Huan Wang, Wasin So

Faculty Research, Scholarly, and Creative Activity

The energy ε(G) of a graph G is the sum of the absolute values of all the eigenvalues of its adjacency matrix. Gutman (2001) pointed out a problem to characterize the graph G and the edge e of G such that ε(G − e) ⩽ ε(G). Tang et al. (2023) gave a sufficient condition for ε(G − e) ⩽ ε(G), where e is not necessarily a cut-edge set or a cut edge. We deduce here a stronger conclusion than the results obtained by Tang et al. (2023). Our findings cover some known conclusions, such as the results obtained by Gutman …

When Swin Transformer Meets Kans: An Improved Transformer Architecture For Medical Image Segmentation, Nishchal Sapkota, Haoyan Shi, Yejia Zhang, Xianshi Ma, Bofang Zheng, Fabian Vazquez Jr.

Computer Science Faculty Publications

Medical image segmentation is critical for accurate diagnostics and treatment planning, but remains challenging due to complex anatomical structures and limited annotated training data. CNN-based segmentation methods excel at local feature extraction, but struggle with modeling long-range dependencies. Transformers, on the other hand, capture global context more effectively, but are inherently data-hungry and computationally expensive. In this work, we introduce UKAST, a U-Net like architecture that integrates rationalfunction based Kolmogorov - Arnold Networks (KANs) into Swin Transformer encoders. By leveraging rational base functions and Group Rational KANs (GR-KANs) from the Kolmogorov - Arnold Transformer (KAT), our architecture addresses the inefficiencies …

Finding Aid For The Mississippi Politics Collection (Mum00316)

Archives & Special Collections: Finding Aids (alphabetical)

Artificially created collection on individual Mississippi politicians and the state’s politics in general.

Centering Community Concerns And Recommendations Amid Rapid Policy Changes: Impacts On Social Protection, Well-Being, And Health Access, Kriti Vashisht

School of Social Work Faculty Publications

Rapidly evolving policies on gender identity and expression have highlighted a wide range of public and political perspectives on whether to limit or support demands for gender identification and healthcare services for the LGBTQ+ community. Due to the rise in these pro and against narratives and incidents, there were increased protection risks for this group. Scholars and practitioners working closely with LGBTQ+ members are witnessing increased distress and concerns among them, creating further barriers to care and heightened stigma. This is why community-based scholars and educators initiated an open consultation to create a non-partisan space for dialogue, reflection, and learning …

Convergence Of Social Justice, Human Rights, And Artificial Intelligence (Ai), Sudershan Pasupuleti, Urmila Yadav, Susheelabai R. Srinivasa

School of Social Work Faculty Publications

Artificial Intelligence and large data machine learning are transforming many areas, including healthcare, economic, political, and educational social institutions, at their best. Artificial intelligence can also be offered the moral and legal potential to safeguard human rights and social justice in society. For instance, human rights organizations scan public domain images for evidence of abuse, or software uses adversarial techniques to reduce bias in training data. At best, some organizations and businesses are tackling these challenges in a proactive manner, looking for methods to make sure they avoid or identify concerns before they arise; for others, this may be a …

“Full And Equal Access”: A Socio-Ecological Model Of Healthcare Ableism Experienced By The Blind And The Low Vision Community, Rebecca Fischbein, Rachel Conrad Bracken, Allyson S. Hughes, Rayyan Bhutta, Nazanin M. Heydarian

School of Social Work Faculty Publications

In 2023, the National Institutes of Health (NIH) designated people with disabilities as a population experiencing health disparities, citing “a wide and varying range of health conditions leading to poorer health and shorter lifespan” and “discrimination, inequality and exclusionary structural practices” contributing to pervasive health inequities. As blindness and low vision (BLV) become increasingly common due to an aging population coupled with higher rates of type 2 diabetes, more people who are BLV will require quality care. Yet, people who are BLV face many barriers to care, including healthcare provider and staff (HCP) ableism. In this chapter, we propose a …

Improving Pid Control With Bayesian Optimization For Adversarially Robust Federated Learning, Adrian Pena, Sergei Chuprov, Raman Zatsarenko, Leon Reznik

Computer Science Faculty Publications

Federated Learning (FL) often suffers from unstable convergence and reduced robustness under non-IID data and malicious attacks. In this paper, we present FedPIDAvg_tuned, a control-theoretic aggregation framework for improving stability and adversarial robustness in FL. In particular, our approach combines a server-side Proportional–Integral–Derivative (PID) controller with Bayesian optimization to tune controller gains for different data and attack conditions. The PID controller regulates global model updates through feedback on loss dynamics, providing adaptive scaling that improves stability and convergence. The tuned gains are applied within a trust-weighted trimmed-mean mechanism to remove adversarial or outlier updates. Using the Flower framework, we evaluate …

Broadening Replication Standards For Vignette Studies: Introducing Contextually Appropriate Replications, Birgit Schyns, Gretchen Vogelgesang Lester, Michelle M. Hammond

Faculty Research, Scholarly, and Creative Activity

Vignette studies present specific challenges for replications, yet vignettes are a popular choice for replication studies in leadership. In our review of eight vignette-based leadership publications, only two were able to fully replicate the original study's findings. We suggest that part of the failure to replicate the results of vignette studies may be due to a misalignment between the vignettes and social reality at the time of data collection. This paper highlights the challenges vignettes present due to societal progression and includes recommendations regarding potential methodological artifacts including the appropriateness of the sample, vignette content, and modality. We first discuss …

Organic Pollutants And Risk Of Type 2 Diabetes: A Systematic Review And Meta-Analysis, Yousif M. Hydoub, Ricardo Loor-Torres, Abdul Qadeer, Kinaan Farhan, Thaer K. Swaid, Hanieh S.T. Yeganeh, Joelle N. Friesen, Shangwe Kiliaki, Iman Fawad, Danielle J. Gerberi, Thirumurugan Prakasam, Rainer Lohmann, H. Hassan Murad, Sagar B. Dugani

Graduate School of Oceanography Faculty Publications

Objective: To evaluate the associations between organic pollutants (OPs) and risk of type 2 diabetes (T2D).

Patients and Methods: We searched Medline, Embase, Scopus, Web of Science, and Cochrane Central from inception through March 18, 2024. We included studies reporting the adjusted or unadjusted association between serum concentration of OPs and risk of T2D. We excluded studies on type 1 diabetes, self-reported exposure, and if fewer than 100 T2D cases. We classified OPs using 2 classification methods and reported pooled risk estimates using a random-effects model (odds ratio [95% CI]) and assessed risk of bias at the levels …

A Call To Action: Engaging With The Intergovernmental Science-Policy Panel On Chemicals, Waste And Pollution, Miriam L. Diamond, Gabriel Sigmund, Marlene Ågerstrand, Michael G. Bertram, Alex T. Ford, Rainer Lohmann, Andreas Schäffer, Maria Clara V.M. Starling, Anna Soehl, Noriyuki Suzuki, Penny Vlahos, Marta Venier, Martin Scheringer

Graduate School of Oceanography Faculty Publications

No abstract provided.

Global Inventory Of Fluoropolymer Production Plants And Their Associated Pfas Environmental Contamination, Anna J. Miller, Kevin Kleemann, Juliane Glüge, Rainer Lohmann, Ian T. Cousins, Dorte Herzke, Mark F. Miller, Amanda Rensmo, Xenia Trier, Zhanyun Wang, Martin Scheringer

Graduate School of Oceanography Faculty Publications

Fluoropolymers are widely used across sectors, but their production is associated with emissions of perfluoroalkyl and polyfluoroalkyl substances (PFASs), which are mobile, persistent, and toxic. In this work, we compiled a global inventory of fluoropolymer production plants (FPPs) and assembled PFAS concentration measurements for various media in their vicinity. We identified 52 currently operating FPPs across 11 countries and 41 cities. For 12 FPPs, in 12 different cities, there are peer-reviewed site-specific PFAS measurements specifically attributed to the FPP. At these 12 sites, at least 236 individual PFASs have been detected across multiple environmental media, including surface water, groundwater, air, …

Preliminary Cruise Report: Tn452 Eastern Lau Spreading Center And Northeastern Lau Basin, Kingdom Of Tonga, April 19, 2026 – May 18, 2026, Roxanne A. Beinart, Shawn Arellano

Graduate School of Oceanography Faculty Publications

No abstract provided.

Molecular Detection Of Campylobacter Spp. In Filth Flies Associated With Broiler Breeder Facilities In Oklahoma And Arkansas, Allen Szalanski

Entomology and Plant Pathology Faculty Publications and Presentations

Adult filth flies (Diptera: Muscidae) (non-biting flies that develop in decaying organic matter) are abundant in poultry facilities and may contribute to the dissemination of pathogenic Campylobacter spp. among flocks. We sampled adult house flies, Musca domestica L., and black dump flies, Hydrotaea aenescens (Wiedemann), at five broiler-breeder farms in Oklahoma and Arkansas to determine the prevalence of Campylobacter spp. vectored by filth flies and the effects of farm, fly species, and location (inside vs outside houses) on the rates of Campylobacter spp. occurrence. A total of 1,076 house flies and 1,008 black dump flies were collected inside and outside …