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Articles 107761 - 107790 of 107906
Full-Text Articles in Entire DC Network
The Role Of Physical Therapy Across The Transplant Trajectory In Allogeneic Hematopoietic Stem Cell Transplantation, A Systematic Review And Clinical Framework, Houssem Ben Jemia, Rebecca Catterina, Marialaura Calonghi, Maria Anna Dossena, Stefano Giuseppe Lazzarini, Francesco Bettariga, Michele Malagola, Enrico Morello
The Role Of Physical Therapy Across The Transplant Trajectory In Allogeneic Hematopoietic Stem Cell Transplantation, A Systematic Review And Clinical Framework, Houssem Ben Jemia, Rebecca Catterina, Marialaura Calonghi, Maria Anna Dossena, Stefano Giuseppe Lazzarini, Francesco Bettariga, Michele Malagola, Enrico Morello
Research outputs 2022 to 2026
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) increasingly involves older and medically complex patients, in whom impaired pulmonary function and high comorbidity burden adversely affect survival and long-term outcomes. Rehabilitation and exercise interventions are biologically plausible strategies to mitigate deconditioning along the transplant trajectory, but their role in allo-HSCT has not been systematically organized within a phase-specific clinical framework. A systematic review of randomized controlled trials (RCTs) was conducted according to Cochrane guidance and PRISMA 2020, with prospective registration in PROSPERO. PubMed, Embase, PEDro, Web of Science, CENTRAL and Scopus were searched from inception to early 2025, with an updated PubMed …
Understanding Barriers And Motivators For Fruit And Vegetable Intake In Female Stroke Survivors: A Qualitative Study, Caroline R. Hill, Jack Dalla Via, Lauren C. Blekkenhorst, Montana Dupuy, Rosanne Freak-Poli, Liezhou Zhong, Jonathan M. Hodgson, Moira Sim, Mandy Stanley, Amanda Devine, Simone Radavelli-Bagatini
Understanding Barriers And Motivators For Fruit And Vegetable Intake In Female Stroke Survivors: A Qualitative Study, Caroline R. Hill, Jack Dalla Via, Lauren C. Blekkenhorst, Montana Dupuy, Rosanne Freak-Poli, Liezhou Zhong, Jonathan M. Hodgson, Moira Sim, Mandy Stanley, Amanda Devine, Simone Radavelli-Bagatini
Research outputs 2022 to 2026
Purpose: Adequate fruit and vegetable (FV) intake is the foundation of a healthy diet; however, intake is especially low among stroke survivors. This study explores barriers and motivators to FV intake in female stroke survivors and informs strategies to improve well-being.
Methods: Female stroke survivors completed questionnaires and attended either a focus group or an interview, with the resulting transcripts analysed using reflexive thematic analysis.
Results: Ten female stroke survivors aged (mean [SD]) 66.3 [17.1] years completed the study. Across the focus groups (n = 3) and interviews (n = 2), three themes emerged: (1) “Navigating alone,” reported that survivors …
When Does The Peak Countermovement Jump Performance Occur? Mapping Peak-Trial Timing Across Six Clustered Repetitions, Karol Kruczek, Szymon Karpęcki, Tim Gabbett, Jason Lake, Michał Nowak
When Does The Peak Countermovement Jump Performance Occur? Mapping Peak-Trial Timing Across Six Clustered Repetitions, Karol Kruczek, Szymon Karpęcki, Tim Gabbett, Jason Lake, Michał Nowak
Research outputs 2022 to 2026
Force-plate countermovement jump (CMJ) testing is widely used to assess neuromuscular status, yet monitoring interpretation often relies on best-trial values from abbreviated protocols, potentially biasing conclusions when the session maximum occurs beyond the sampled attempts. We mapped peak-trial timing across a six-trial clustered (3 + 3) CMJ protocol for seven outcome and strategy force–time metrics, and tested whether this peak-trial pattern was preserved between personal best (PB) and typical state (TS) monitoring sessions, both defined using modified reactive strength index (mRSI) as the primary selection variable. Retrospective dual-force-plate data (1000 Hz; August 2020–December 2025) were analysed from 314 athletes who …
Women Are Discriminated Against On The Basis Of Sex: Anti-Trans Epistemologies In Australian Universities, Emily M. Gray, Jacqueline Ullman, Mindy Blaise
Women Are Discriminated Against On The Basis Of Sex: Anti-Trans Epistemologies In Australian Universities, Emily M. Gray, Jacqueline Ullman, Mindy Blaise
Research outputs 2022 to 2026
This article offers an analysis of qualitative data from a multi-phased project entitled Understanding and Addressing Everyday Sexisms in Australian Universities. The project’s key aim was to improve the ways in which gender-based discrimination is understood and addressed in Australian universities. It achieved this aim through adopting a situated, intersectional, and creative approach to data generation and analysis. The authors examine data from phase three of the project, a large-scale survey that was distributed across 12 of Australia’s 39 public universities, yielding 1257 responses. The survey was designed to encourage academic staff of all genders to participate and aimed to …
Multi-Omics Integration Reveals Vaccine-Specific Molecular Signatures And Temporal Dynamics Of Covid-19 Immune Responses, Anne H. Klein, David J. Beale, Thao V. Nquyen, Jian-Wei Liu, Petrus Jansen Van Vuren, Nagendrakumar B. Singanallur, Carol Lee, Andrew C. Boomer, Jennifer A. Juno, Stephen J. Kent, Adam K. Wheatley, Gough G. Au, Seshadri S. Vasan, Laurence Wilson, Alexander J. Mcauley
Multi-Omics Integration Reveals Vaccine-Specific Molecular Signatures And Temporal Dynamics Of Covid-19 Immune Responses, Anne H. Klein, David J. Beale, Thao V. Nquyen, Jian-Wei Liu, Petrus Jansen Van Vuren, Nagendrakumar B. Singanallur, Carol Lee, Andrew C. Boomer, Jennifer A. Juno, Stephen J. Kent, Adam K. Wheatley, Gough G. Au, Seshadri S. Vasan, Laurence Wilson, Alexander J. Mcauley
Research outputs 2022 to 2026
Vaccination elicits systemic immune responses that extend beyond antibody and lymphocyte activation, engaging coordinated metabolic and lipid pathways that modulate immune function. Nevertheless, how systemic molecular responses differ across COVID-19 vaccine platforms, including closely related mRNA platforms, remains poorly understood. Here, we performed integrated plasma proteomic, lipidomic, and metabolomic profiling of 53 SARS-CoV-2–naïve adults vaccinated with Pfizer-BioNTech, Moderna, or AstraZeneca COVID-19 vaccines. Samples were analysed across multiple timepoints using differential analysis and DIABLO-based multi-omics integration. Our findings reveal distinct platform-associated multi-omic molecular signatures not captured by unsupervised analyses alone. Pfizer-BioNTech vaccination was associated with widespread increases in immunoglobulin and complement …
Infant Sensory Gating And A Developmental Cascade To Autistic Traits And Anxiety, Rebecca F Schwarzlose
Infant Sensory Gating And A Developmental Cascade To Autistic Traits And Anxiety, Rebecca F Schwarzlose
2020-Current year OA Pubs
Disruptions to the infant sensory environment can have lasting effects on neural response properties and behavior in both humans and animals. Recent work has begun to highlight an additional factor in infant sensory experience: differences in inhibitory signaling and sensory gating. Converging work from human and animal studies has begun to implicate a developmental cascade by which impaired sensory gating during a sensitive period of neonatal neurodevelopment promotes a phenotype of sensory over-responsivity, autistic traits, anxiety, and other psychiatric challenges. In this Review, I propose a model for this developmental cascade and highlight how differences in infant sensory responsivity represent …
Characteristics And Outcomes Of Patients With Hematologic Malignancies Hospitalized With Respiratory Viral Infections, Zulfiqar A Lokhandwala, Brenna Park-Egan, Ravneet Waraich, Colleen A Mcevoy, Andrew P Michelson, Alice F Bewley, Lynne Strasfeld, Rachel Cook, Brandon Hayes-Lattin, Catherine L Hough, Patrick G Lyons
Characteristics And Outcomes Of Patients With Hematologic Malignancies Hospitalized With Respiratory Viral Infections, Zulfiqar A Lokhandwala, Brenna Park-Egan, Ravneet Waraich, Colleen A Mcevoy, Andrew P Michelson, Alice F Bewley, Lynne Strasfeld, Rachel Cook, Brandon Hayes-Lattin, Catherine L Hough, Patrick G Lyons
2020-Current year OA Pubs
BACKGROUND: Respiratory viral infections in patients with hematologic malignancies or hematopoietic stem cell transplants (HCTs) are associated with increased morbidity and mortality. However, the hospital presentations and courses of these infections remain under-described.
METHODS: We performed a multicenter retrospective cohort study of hospitalized patients with hematologic malignancy or HCT at 2 comprehensive cancer centers between January 2019 and June 2023. We included all patients with acute viral respiratory infection (identified based on a constellation of test results and objective physiology), comparing clinical presentations, care processes, and patient outcomes across pathogens; the primary outcome was the composite of hospital death or …
Steroid Hormone Metabolites And Mammographic Breast Density In Premenopausal Women, Ghazaleh Pourali, Kayode A Matthew, Myung Sik Jeon, Chongliang Luo, Gary J Patti, Jingqin Luo, Adetunji T Toriola
Steroid Hormone Metabolites And Mammographic Breast Density In Premenopausal Women, Ghazaleh Pourali, Kayode A Matthew, Myung Sik Jeon, Chongliang Luo, Gary J Patti, Jingqin Luo, Adetunji T Toriola
2020-Current year OA Pubs
BACKGROUND: Steroid hormones influence breast morphology and cellular proliferation and are associated with breast carcinogenesis. However, their associations with mammographic breast density (MBD) are less studied, particularly in premenopausal women. We, therefore, investigated the associations of steroid hormone metabolites with MBD in premenopausal women.
METHODS: Our study included 700 premenopausal women scheduled for screening mammograms. We analyzed 54 steroid hormone metabolites (Metabolon®) and assessed volumetric measures of MBD including volumetric percent density (VPD), dense volume (DV), and non-dense volume (NDV) using Volpara. We investigated associations using linear regression modeling to estimate the covariate-adjusted means of VPD, NDV, and DV, corresponding …
Intraoperative Neurophysiological Monitoring In Full-Endoscopic Cervical Endoscopic Ulbd, Miles Hudson, Sarah Esposito, Mark M Zaki, Simon M Glynn, Osama N Kashlan, John Ogunlade, Chandan Krishna, Joshua Bakhsheshian, Christoph P Hofstetter
Intraoperative Neurophysiological Monitoring In Full-Endoscopic Cervical Endoscopic Ulbd, Miles Hudson, Sarah Esposito, Mark M Zaki, Simon M Glynn, Osama N Kashlan, John Ogunlade, Chandan Krishna, Joshua Bakhsheshian, Christoph P Hofstetter
2020-Current year OA Pubs
No abstract provided.
Preparing For Long-Acting Technologies: A Multistate Analysis Of Prep Persistence And Hiv And Sti Lab Coverage Among Oral Prep Initiators In St. Louis, Missouri (2014-2021), Lindsey M Filiatreau, Rupa Patel, Kate Curoe, Ashley Underwood, Joseph Cherabie, Elvin H Geng, Aditi Ramakrishnan, Rachel Presti, Aaloke Mody
Preparing For Long-Acting Technologies: A Multistate Analysis Of Prep Persistence And Hiv And Sti Lab Coverage Among Oral Prep Initiators In St. Louis, Missouri (2014-2021), Lindsey M Filiatreau, Rupa Patel, Kate Curoe, Ashley Underwood, Joseph Cherabie, Elvin H Geng, Aditi Ramakrishnan, Rachel Presti, Aaloke Mody
2020-Current year OA Pubs
BACKGROUND: Engagement in pre-exposure prophylaxis (PrEP) care and routine screening for HIV and sexually transmitted infections (STIs) is critical to realizing the full benefits of this HIV prevention strategy.
METHODS: We enrolled a cohort of individuals seeking PrEP services in two clinics in Missouri, an Ending the HIV Epidemic priority state, from June 2014 to November 2021. We used electronic health record and survey data to explore outcomes in the 2 years following linkage to care using multistate methods. We assessed transitions between eight mutually exclusive care states differentiated by receipt of a prescription, lab coverage status, and retention. We …
Epithelial-Mesenchymal Transition And Stress Adaptations Underlie Yttrium-90 Resistance In Liver Cancer Cell Lines, Alexander Zheleznyak, Dhanusha Duraiyan, Prasanth Thunuguntla, Jessica Camacho, Shuang Wu, Jingxia Liu, Jason D Weber, Daniel L J Thorek, Benjamin S Strnad, Ryan C Fields, Matthew A Ciorba, Christine Yoon, Valerie Blanc, Nicholas Davidson, Jessica Silva-Fisher, Christopher D Malone
Epithelial-Mesenchymal Transition And Stress Adaptations Underlie Yttrium-90 Resistance In Liver Cancer Cell Lines, Alexander Zheleznyak, Dhanusha Duraiyan, Prasanth Thunuguntla, Jessica Camacho, Shuang Wu, Jingxia Liu, Jason D Weber, Daniel L J Thorek, Benjamin S Strnad, Ryan C Fields, Matthew A Ciorba, Christine Yoon, Valerie Blanc, Nicholas Davidson, Jessica Silva-Fisher, Christopher D Malone
2020-Current year OA Pubs
UNLABELLED: Molecular signatures predict prognosis in hepatocellular carcinoma, but their relevance to transarterial radioembolization (TARE) with yttrium-90 (90Y) is unknown. We aimed to identify baseline and treatment-induced pathways associated with response and nominate biomarkers. Ten transcriptomically diverse human liver cancer cell lines were exposed to escalating activities of glass 90Y microspheres for 10 days. Normalized AUC values quantified sensitivity. Whole-transcriptome RNA sequencing at baseline and after treatment was analyzed with elastic net regression and gene set enrichment. Findings were corroborated by qRT-qPCR and exploratory analysis of pretreatment tumor samples from patients undergoing TARE. Liver cancer cell line responses to 90Y …
The Cognitive-Affective Social Processing And Emotion Regulation (Casper) Model, M Catalina Camacho, Elina Deshpande, Michael T Perino
The Cognitive-Affective Social Processing And Emotion Regulation (Casper) Model, M Catalina Camacho, Elina Deshpande, Michael T Perino
2020-Current year OA Pubs
Humans are intensely social creatures. It is therefore not surprising that many psychiatric disorder criteria include social dysfunctions; however, overlapping presentations and diverse, complex etiologies make treating social dysfunctions difficult. Here, we introduce the Cognitive Affective Social Processing and Emotion Regulation (CASPER) model. CASPER integrates research from social psychology, cognitive neuroscience, and developmental science to describe how real-world social processing unfolds and is associated with differing psychiatric social cognitive neurophenotypes. Briefly, social processing can be broken down into the following cognitive steps: identifying relevant social cues, attending to related cues, interpreting cues, and adjusting behavior appropriately. Each of these steps …
Frontline Aspiration Versus Stent Retriever Thrombectomy For M2 Occlusions: Insights From The Star Registry, Michael Gaub, Joshua Osbun, Et Al.
Frontline Aspiration Versus Stent Retriever Thrombectomy For M2 Occlusions: Insights From The Star Registry, Michael Gaub, Joshua Osbun, Et Al.
2020-Current year OA Pubs
BACKGROUND: Recent trials have furthered uncertainty regarding the endovascular benefit for medium vessel occlusions (MeVO). Stent retrievers (SR) were employed in the first attempt in most interventional arm participants. We sought to compare outcomes in acute MCA M2 occlusions between frontline aspiration and SR, and to delineate procedural and anatomical covariates associated with differential treatment effect.
METHODS: Retrospective analysis of a multicenter stroke thrombectomy cohort identified cases of MT for M2 occlusions. Unmatched and propensity score-matched (PSM) cohorts were generated comparing frontline aspiration to standalone and combined SR. The primary outcome was functional independence (mRS 0-2) at 90 days. Recanalization, …
A Microenvironment-Driven Hla-Ii-Associated Insulin Neoantigen Elicits Persistent Memory T Cell Activation In Diabetes, Neetu Srivastava, Anthony N Vomund, Rongzhen Yu, Orion J Peterson, Yuqing Yang, David P Turicek, Omar Abousaway, Tiandao Li, Pamela Stone, Aisha Ansar, Rima Melhem, Bo Zhang, Chang Liu, Hao Hu, Chyi-Song Hsieh, Laura Campisi, Emil R Unanue, Ana Maria Arbelaez, Cheryl F Lichti, Xiaoxiao Wan, Et Al.
A Microenvironment-Driven Hla-Ii-Associated Insulin Neoantigen Elicits Persistent Memory T Cell Activation In Diabetes, Neetu Srivastava, Anthony N Vomund, Rongzhen Yu, Orion J Peterson, Yuqing Yang, David P Turicek, Omar Abousaway, Tiandao Li, Pamela Stone, Aisha Ansar, Rima Melhem, Bo Zhang, Chang Liu, Hao Hu, Chyi-Song Hsieh, Laura Campisi, Emil R Unanue, Ana Maria Arbelaez, Cheryl F Lichti, Xiaoxiao Wan, Et Al.
2020-Current year OA Pubs
The antigenic landscape of autoimmune diabetes reflects a failure to preserve self-tolerance, yet how novel neoantigens emerge in humans remains incompletely understood. Here we designed an immunopeptidomics-based approach to probe HLA-II-bound, islet-derived neoepitopes in patients with type 1 diabetes. We uncovered a Cys→Ser transformation, conserved between mice and humans, that reshapes autoreactivity to insulin at the single-residue level. This transformation, which we call C19S, arises from oxidative remodeling of insulin in stressed pancreatic islets and also occurs in cytokine-activated antigen-presenting cells, contributing to a feed-forward loop of neoepitope formation and presentation. Despite involving just one amino acid, C19S is recognized …
Focused Ultrasound-Enhanced Nose-To-Brain Delivery Of A Therapeutic Antibody In A Large-Animal Model, Siaka Fadera, Cristian Antonio Wieczorek Villas Boas, Yimei Yue, Zhaoning Gu, Jinyun Yuan, Debolina De, Buck E Rogers, Arash Nazeri, Hong Chen
Focused Ultrasound-Enhanced Nose-To-Brain Delivery Of A Therapeutic Antibody In A Large-Animal Model, Siaka Fadera, Cristian Antonio Wieczorek Villas Boas, Yimei Yue, Zhaoning Gu, Jinyun Yuan, Debolina De, Buck E Rogers, Arash Nazeri, Hong Chen
2020-Current year OA Pubs
No abstract provided.
Mutations In Hsp40 Co-Chaperone Change The Canonical Interdomain Interactions Stimulating Lgmdd1 Myopathy, Ankan K Bhadra, Geetika Aggarwal, Anshuman Jaysingh, Daniel Chen, Jil Daw, Conrad C Weihl, Heather L True
Mutations In Hsp40 Co-Chaperone Change The Canonical Interdomain Interactions Stimulating Lgmdd1 Myopathy, Ankan K Bhadra, Geetika Aggarwal, Anshuman Jaysingh, Daniel Chen, Jil Daw, Conrad C Weihl, Heather L True
2020-Current year OA Pubs
Limb-girdle muscular dystrophy D1 (LGMDD1) is a rare, dominantly inherited neuromuscular protein-misfolding chaperonopathy caused by mutations in the Hsp40 co-chaperone DNAJB6, primarily in the glycine-phenylalanine (GF) or J-domains. Currently, no treatments are available, and a challenge in understanding the disease is identifying a specific client protein for DNAJB6 in skeletal muscle. DNAJB6 has homology to the yeast DNAJ family member, Sis1. Our previous research indicated that LGMDD1 GF domain mutants in Sis1 exhibit substrate-specific effects, influenced by Hsp70 activity. Herein, we employed functional assays along with advanced molecular simulation studies to understand the regulatory interdomain interactions in disease-causing mutants of …
A Deep Learning Model To Guide Personalized Mechanical Circulatory Support Use In Cardiogenic Shock Patients Undergoing Pci, Amit P Amin, Richard G Bach, Darren C Tsang, Weili S Zheng, Raed A Qarajeh, Emmanouil S Brilakis, Hemant Kulkarni
A Deep Learning Model To Guide Personalized Mechanical Circulatory Support Use In Cardiogenic Shock Patients Undergoing Pci, Amit P Amin, Richard G Bach, Darren C Tsang, Weili S Zheng, Raed A Qarajeh, Emmanouil S Brilakis, Hemant Kulkarni
2020-Current year OA Pubs
BACKGROUND: Cardiogenic shock (CS) in patients undergoing percutaneous coronary intervention (PCI) involves rapidly changing clinical, hemodynamic, and metabolic factors that current models cannot effectively integrate.
OBJECTIVES: The purpose of this study was to develop and validate a deep learning (DL) model to guide personalized use of mechanical circulatory support (MCS) devices in CS patients undergoing PCI.
METHODS: The authors analyzed data from 1,408 CS patients treated with intra-aortic balloon pump (IABP) or microaxial flow-pump (mAFP) at multiple hospitals (2004-2019). Clinical, hemodynamic, and metabolic variables from admission to MCS placement were compiled into longitudinal vectors. Using Python 3.7 and TabNet in …
Genome-Wide Gene-Sleep Interaction Study Identifies Novel Lipid Loci In 732,564 Participants, Raymond Noordam, Karen Schwander, Lisa De Las Fuentes, Mary F Feitosa, Anh Do, C Charles Gu, Changwei Li, Michael A Province, Dabeeru C Rao, Et Al.
Genome-Wide Gene-Sleep Interaction Study Identifies Novel Lipid Loci In 732,564 Participants, Raymond Noordam, Karen Schwander, Lisa De Las Fuentes, Mary F Feitosa, Anh Do, C Charles Gu, Changwei Li, Michael A Province, Dabeeru C Rao, Et Al.
2020-Current year OA Pubs
BACKGROUND AND AIMS: Deviations from the population mean in sleep duration have been associated with increased risk for developing dyslipidemia and atherosclerotic cardiovascular disease, but the mechanism of effect is poorly characterized. We performed large-scale genome-wide gene-sleep interaction analyses of lipid levels to identify genetic variants underpinning the biomolecular pathways of sleep-associated lipid disturbances and to suggest possible druggable targets.
METHODS: We collected data from 55 cohorts with a combined sample size of 732,564 participants (87 % European ancestry) with data on lipid traits (high-density lipoprotein [HDL-c] and low-density lipoprotein [LDL-c] cholesterol and triglycerides [TG]). Short (STST) and long (LTST) …
Airway Management In Emergency Department Thoracotomy: A Narrative Review, Aaron J Lacy, Adam Liebendorfer, Sarah M Guess, Rami S Al-Aref, Anthony P Kronfli, Rachel E Armstrong, Amelia W Maiga, Alexander Bracey, Ryan N Barnicle
Airway Management In Emergency Department Thoracotomy: A Narrative Review, Aaron J Lacy, Adam Liebendorfer, Sarah M Guess, Rami S Al-Aref, Anthony P Kronfli, Rachel E Armstrong, Amelia W Maiga, Alexander Bracey, Ryan N Barnicle
2020-Current year OA Pubs
INTRODUCTION: Emergency department thoracotomy (EDT) is a high-risk, life-saving intervention for patients in traumatic cardiac arrest. A critical component of EDT is airway management, typically performed by emergency physicians, yet formal guidance regarding optimal strategies remains limited. Airway management in this setting is uniquely complex due to concurrent anatomic injury, physiologic instability, and the procedural demands of thoracotomy.
DISCUSSION: Endotracheal intubation (ETI) during EDT presents multiple challenges. Anatomic difficulties may arise from facial or cervical trauma, restricted positioning, and the presence of cervical collars. Cognitive load is heightened by the chaotic, multidisciplinary environment, requiring strategies such as pre-briefing, checklists, and …
Foot-Specific Exercise Intervention For Forefoot Deformity In Individuals With Type 2 Diabetes And Peripheral Neuropathy: A Randomized Controlled Clinical Trial With 3-Year Follow-Up, J A Zellers, K Steger-May, P K Commean, H-J Jeong, E M Bullard, M J Mueller, M K Hastings
Foot-Specific Exercise Intervention For Forefoot Deformity In Individuals With Type 2 Diabetes And Peripheral Neuropathy: A Randomized Controlled Clinical Trial With 3-Year Follow-Up, J A Zellers, K Steger-May, P K Commean, H-J Jeong, E M Bullard, M J Mueller, M K Hastings
2020-Current year OA Pubs
BACKGROUND: Diabetes with peripheral neuropathy can lead to metatarsophalangeal joint (MTPJ) deformity. The purpose of this study was to estimate the effect of a foot-specific intervention on MTPJ deformity. Secondary aims were determining MTPJ deformity progression over 3 years and predictors of MTPJ deformity progression.
METHODS: Sixty people with type 2 diabetes and peripheral neuropathy were recruited for this randomized controlled clinical trial. Participants were assessed at baseline, 6 months (post-intervention), 1.5 years, and 3 years. A 6-month, foot-specific intervention in the experimental group was compared to a shoulder intervention in the control group. The primary outcome was change in …
Excellent Outcomes In Feasibility Study Of Radiation-Free Conditioning And Transplant In Pediatric Severe Aplastic Anemia, Mithra Lakshmi Narasimhan, Irem Eldem, Jeffrey J Bednarski, Ginny L Schulz, Robert J Hayashi, Shalini Shenoy
Excellent Outcomes In Feasibility Study Of Radiation-Free Conditioning And Transplant In Pediatric Severe Aplastic Anemia, Mithra Lakshmi Narasimhan, Irem Eldem, Jeffrey J Bednarski, Ginny L Schulz, Robert J Hayashi, Shalini Shenoy
2020-Current year OA Pubs
Severe aplastic anemia (SAA) is treated with a hematopoietic cell transplant (HCT) in the presence of an HLA-matched sibling donor (MSD) with disease-free survival (DFS) of >90%. In the absence of an MSD, immunosuppressive therapy (IST) can induce remission but concerns for relapsed/refractory disease and clonal hematopoiesis persist. IST failure is an indication for HCT. Modern HCT approaches target barriers such as graft rejection (GR), graft-versus-host disease (GVHD), and transplant-related toxicities. Traditionally, total body irradiation (TBI) inclusive HCT conditioning helps decrease GR, but the use of TBI in children increases concerns for late effects such as malignancies. To describe outcomes …
Cutibacterium Adaptation To Life On Humans Provides A Potential C Acnes Infection Biomarker, Md Shafiuddin, Wen-Chi Huang, Gabriel William Prather, Jeffrey Ryan Anton, Andrew Lawrence Martin, Sydney Brianna Sillart, Jonathan Z Tang, Michael R Vittori, Michael J Prinsen, Jessica Jane Ninneman, Chandrashekhara Manithody, Jeffrey P Henderson, Alexander W Aleem, Ma Xenia Garcia Ilagan, William H Mccoy 4th
Cutibacterium Adaptation To Life On Humans Provides A Potential C Acnes Infection Biomarker, Md Shafiuddin, Wen-Chi Huang, Gabriel William Prather, Jeffrey Ryan Anton, Andrew Lawrence Martin, Sydney Brianna Sillart, Jonathan Z Tang, Michael R Vittori, Michael J Prinsen, Jessica Jane Ninneman, Chandrashekhara Manithody, Jeffrey P Henderson, Alexander W Aleem, Ma Xenia Garcia Ilagan, William H Mccoy 4th
2020-Current year OA Pubs
Propionibacteriaceae appear to have adapted to life on humans during the domestication of cattle. These microbial immigrants formed the genus Cutibacterium, and a descendent of those microbial trailblazers (C acnes) now dominates 25% of human skin. C acnes colonization of human skin requires the protein RoxP. Although all Cutibacteria encode this adaptation to life on humans, nothing like RoxP has been found in any other organism. In this study, we report an extensive assessment of 21 RoxP orthologs, which identified conserved molecular surfaces linked to heme-dependent oligomerization and low pH stability. Our investigation suggests how RoxP helps C acnes dominate …
Centring The Audience: Attitudes And Behaviours In Australian Arts Organisations, Katya Johanson, Abbie Trott, Mark Taylor, Anne Kershaw, Hilary Glow, Tracy Margieson
Centring The Audience: Attitudes And Behaviours In Australian Arts Organisations, Katya Johanson, Abbie Trott, Mark Taylor, Anne Kershaw, Hilary Glow, Tracy Margieson
Research outputs 2022 to 2026
Many arts organisations seek to increase the diversity of their audiences. Recent literature suggests that this requires organisations to interrogate and change their ways of operating. This is a fundamental shift for a sector that has long considered the goal of diversifying audiences as a problem external to the organisation. Responding to this discrepancy, this article compares attitudes and behaviours among workers in arts organisations, to identify whether staff see the need to make change and practise the behaviours required. It identifies and uses three organisational capabilities–‘dynamic capabilities’, ‘social networks’ and ‘business improvement processes’–to frame an analysis of a national …
Chronicles Of Film Tourism: An Integrative Review And Future Research Directions, Sangkyun Kim, Anton Klarin, Stijn Reijnders, Qijie Xiao, Nicky Van Es
Chronicles Of Film Tourism: An Integrative Review And Future Research Directions, Sangkyun Kim, Anton Klarin, Stijn Reijnders, Qijie Xiao, Nicky Van Es
Research outputs 2022 to 2026
This study triangulates historiographical and scientometric reviews to provide a systems perspective on film tourism. The three phases of historiographical analysis (exploration, growth, and maturity) correspond to the three clusters of scientometric analysis: (i) initial research exploring film tourism development and management, (ii) growing the field through studies on film tourists’ perceptions and practices, and (iii) reaching maturity through extending research into different cultural contexts and meaning-making processes. Based on the analysis, we offer a set of directions for future research, including the need to integrate sustainability research and film tourism studies in developing country contexts, as well as intertextuality …
School Library Professionals’ Perspectives On Current And Future Workforce Challenges, Margaret Kristin Merga, Saiyidi Mat Roni
School Library Professionals’ Perspectives On Current And Future Workforce Challenges, Margaret Kristin Merga, Saiyidi Mat Roni
Research outputs 2022 to 2026
While school library professionals work across many nations, supporting student learning and wellbeing, there is limited current research capturing shared issues faced by this educational workforce. The International School Library Workforce Survey collected insights from 971 respondents across 63 countries derived from analysis of both quantitative and qualitative data. Findings suggest that in an international context, school library professionals are experiencing notable issues that impact upon their morale and their ability to enact their professional roles. Respondents were more likely to disagree then agree that school library professionals were typically valued in their country. While the vast majority of respondents …
Crisis Planning Intentions Among Hotel Managers: What Have We Learned From The Covid-19 Pandemic?, Feliani Tjong, Edmund Goh, Violetta Wilk
Crisis Planning Intentions Among Hotel Managers: What Have We Learned From The Covid-19 Pandemic?, Feliani Tjong, Edmund Goh, Violetta Wilk
Research outputs 2022 to 2026
This study investigates the motivational factors which influence future crisis planning intentions, by utilising the Theory of Planned Behaviour (TPB) as the underlying theoretical framework. This research focuses on understanding the attitudes, subjective norms, and perceived behavioural control of hotel managers’ intentions regarding future crisis planning. To enhance the TPB model, the study incorporates two additional variables: perceived risk and past behaviour, thereby addressing previous calls to extend the TPB model. Employing a qualitative methodology, semi-structured interviews (n = 21) were conducted with hotel managers who worked at government-appointed quarantine hotels in Australia during the COVID-19 pandemic. Thematic analysis was …
How Supply Networks Influence Sustainable Innovation: Evidence From Ghana's Public Works Procurement, Peter Adjei-Bamfo, Hadrian Geri Djajadikerta, Kerry Brown, Ferry Jie, Reza Kiani Mavi, Alain Neher
How Supply Networks Influence Sustainable Innovation: Evidence From Ghana's Public Works Procurement, Peter Adjei-Bamfo, Hadrian Geri Djajadikerta, Kerry Brown, Ferry Jie, Reza Kiani Mavi, Alain Neher
Research outputs 2022 to 2026
Recent environmental and sustainability standards in procurement increase short-term production and operational costs to suppliers, which are often recouped by charging price premiums for innovative solutions. However, public buyers are less likely to pay such price premiums, resulting in a disincentive among suppliers to bid for innovation (unique) contracts. This article examines how innovation procurement stimulates network emergence to mitigate innovation costs and facilitate suppliers' sustainable innovation capacity. We inductively analyse interview responses, observations, archival data and modified Delphi discussions with technical experts involved in innovation-oriented public works procurement projects (i.e., building, water and road infrastructure) in Ghana. Our findings …
Sexisms And Gender-Washing In Australian Academia: Public Front, Private Realities, Jacqueline Ullman, Emily Gray, Mindy Blaise, Lucy Hobby
Sexisms And Gender-Washing In Australian Academia: Public Front, Private Realities, Jacqueline Ullman, Emily Gray, Mindy Blaise, Lucy Hobby
Research outputs 2022 to 2026
This paper offers an analysis of selected survey findings from a mixed methods research project, entitled Understanding and Addressing Everyday Sexisms in Australian Universities. The project is situated within the context of the negative impact of gender-based discrimination upon the higher education sector in Australia and internationally. The findings discussed in this paper relate to quantitative analyses of selected items from a national survey of over 1200 Australian academics, recruited through 12 public universities. In this paper, the ways in which different participant groups responded to items designed to explore their attitudes towards sexism in the academic workplace, both broadly …
State Responsibility For Violations Of International Humanitarian Law And Human Rights Law By Private Security Companies In Africa: The Case Of The Wagner Group And Africa Corps, Shannon Joy Bosch, Matthew Kimble
State Responsibility For Violations Of International Humanitarian Law And Human Rights Law By Private Security Companies In Africa: The Case Of The Wagner Group And Africa Corps, Shannon Joy Bosch, Matthew Kimble
Research outputs 2022 to 2026
The outsourcing of traditionally military functions in Africa to private military companies (PMCs) such as the Wagner Group and the Africa Corps has been accompanied by violations of international humanitarian law and international human rights law. According to the International Law Commission's Articles on Responsibility of States for Internationally Wrongful Acts, state responsibility for these violations can be imputed to the states that employ PMCs to function as their agents, to exercise government authority or to act in the vacuum left by official authorities. States that do not intervene to prevent these abuses fail their obligations of due diligence through …
Time To Hang Up The Gloves: A Scoping Review Of Evidence On Non-Sterile Glove Use During Intravenous Antimicrobial Preparation And Administration, Natasya Raja Azlan, Debbie Massey, Lesley Andrew, Amanda Towell-Barnard, Seng Giap Marcus Ang, Carol Crevacore, Martina Costello, Aaron Alejandro, Weiting Liu, Naila Zaman, Peta Anne Zimmerman
Time To Hang Up The Gloves: A Scoping Review Of Evidence On Non-Sterile Glove Use During Intravenous Antimicrobial Preparation And Administration, Natasya Raja Azlan, Debbie Massey, Lesley Andrew, Amanda Towell-Barnard, Seng Giap Marcus Ang, Carol Crevacore, Martina Costello, Aaron Alejandro, Weiting Liu, Naila Zaman, Peta Anne Zimmerman
Research outputs 2022 to 2026
Aims: To systematically summarise evidence related to the use of non-sterile gloves when preparing and administering intravenous antimicrobials. Design: Scoping review. Methods: A rigorous scoping review was undertaken following Arksey and O'Malley's (2005) framework and the modified Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for scoping review guidelines (2018). Five databases and grey literature were included in the search. Literature published between 2009 and 2024 was included. Data Sources: Five databases (Medline, CINAHL, EMBASE, Scopus and Web of Science) and the grey literature were searched in February 2024. Results: Three studies were included; however, none directly addressed correct …