Digital Commons Network^™

The Role Of Home Visiting In Addressing Postpartum Care Gaps: Evidence From A Large Community Sample, Aishwarya Vijay, Allison Kemner, Karen Hoerchler, Abigail Edwards, Jeannie C Kelly, Rachel G Tabak, Mark D Huffman, Zainab Mahmoud

2020-Current year OA Pubs

BackgroundMaternal mortality in the United States has doubled over the last two decades, primarily due to cardiovascular disease, with more than half of deaths occurring postpartum. Despite national calls to action, attendance at postpartum clinic visits remains low. The role of alternative care delivery strategies, such as home visiting, remains insufficiently studied.ObjectiveTo describe postpartum clinic visit attendance among participants in a large national home visiting program, identify sociodemographic and clinical factors associated with attendance, and examine how timing and duration of enrollment relate to postpartum follow-up.DesignWe conducted a retrospective cohort study of pregnancy episodes among mothers enrolled in the Parents …

Design And Technology Pre-Service Teachers’ University Course Lived Experiences In Western Australia, Carol K. Puddicombe, Nicola F. Johnson

Research outputs 2022 to 2026

Design and Technology (D&T) education, historically rooted in industrial and manual arts, now integrates design-focused thinking with the practical processes of prototyping and making. Drawing on a doctoral study, this article examines the university course experiences of ten pre-service D&T teachers in Western Australia and how these shaped emerging beliefs and professional identities. Using an interpretivist framework and interpretative phenomenological analysis, interviews with ten final-year pre-service teachers were analysed. Five interrelated themes are examined in this article: knowledgeable lecturers, hands-on practical learning, curriculum breadth, peers, and internal concerns. The findings highlight the importance of current, school-connected lecturers; structured learning that …

Development Of A Clinical Prediction Model To Guide The Selective Use Of Spect/Ct In Papillary Thyroid Cancer, Liya Zhu, Junik Son, Lu Wang, Haifeng Hou, Byeong Cheol Ahn

Research outputs 2022 to 2026

Background: Radioiodine whole-body scan (WBS) is routinely performed after radioiodine therapy in papillary thyroid cancer (PTC), but its two-dimensional nature limits anatomical localization. The addition of single-photon emission computed tomography/computed tomography (SPECT/CT) improves diagnostic accuracy; however, routine use exposes patients to additional radiation, longer imaging time, and higher costs. This study aimed to establish a predictive model to identify which patients with PTC are more likely to benefit by adding SPECT/CT imaging after WBS, enabling selective rather than routine use. Methods: This retrospective study included 265 patients with pathologically confirmed PTC who underwent postoperative radioiodine therapy followed by WBS and …

Do Lineage-Based Inheritance Norms Matter In Kinship Care Arrangements? Exploring Inheritance Paths In Grandparent Kinship Care Practice In Ghana, Hajara Bentum, Alhassan Abdullah, Vicki Banham, Kwadwo Adusei-Asante

Research outputs 2022 to 2026

Kinship lineage and inheritance norms in Ghana play a significant role in shaping family decisions. Research has shown that kinship lineage and inheritance norms determine kin membership for children by specifying whether they belong to their maternal or paternal family, as well as whether they can inherit properties of their biological father or mother. The notion of kinship membership has shaped parenting and child welfare practices in Ghana, including child maintenance payments and parental neglectful behaviours. This research explored whether kinship-based inheritance norms could influence decisions about selecting a grandmother (maternal vs. paternal grandmother) as a child’s caregiver. We interviewed …

Does Class Ability Grouping In Secondary Schools Improve Students’ Literacy Scores On Australia’S Naplan Tests?, Olivia Johnston, Christa Norris, Peter Palamara

Research outputs 2022 to 2026

Many schools choose to use ability grouping, despite longstanding evidence that it is inequitable and does not improve overall academic outcomes. One reason that the practice of grouping students by ‘ability’ continues is because of pressure to perform on standardised tests. Educators hold beliefs that grouping students for English classes, for example, will improve their literacy scores. This paper presents findings from a study about class ability grouping for English in Australia and how different class grouping practices relate with students’ achievement on Australia’s standardised literacy test. The findings draw on data from our Class Ability Grouping Survey, where participant …

Dose–Response Association Between Systemic And Dermatologic Glucocorticoid Use And Type 2 Diabetes Mellitus: A Nationwide Case–Control Study, David Vadsholt, Annika V. Kvist, Chano Sandiramoorthy, Joshua R. Lewis, Peter Vestergaard, Johan Røikjer, Nicklas H. Rasmussen

Research outputs 2022 to 2026

Aims: To investigate the association and dose–response between systemic and topical glucocorticoids and odds of Type 2 diabetes mellitus. Materials and Methods: We conducted a nationwide case–control study using Danish registry data from 2013 to 2021. People aged 40 years or older with incident type 2 diabetes mellitus (n = 149 113) were matched 1:3 with controls (n = 447 339) by age, sex and weighted Charlson Comorbidity Index. Glucocorticoid exposure was defined as ≥ 1 prescription within 1 year before the date of diagnosis and ≥ 2 within 3 years and classified as systemic or topical. Conditional logistic regression …

Dropouts And Refusers: Clinicians’ Insights And Initiatives Into Reducing Treatment Attrition Amongst Young People Who Sexually Offend, James L. Finney, Natalie Gately, Suzanne Rock, Jocelyn Jones

Research outputs 2022 to 2026

Sexual offending by young people causes significant harm to victims, families and communities. Treatment engagement and completion are therefore important for reducing future harm; however, young people who drop out of, or refuse to engage in, treatment present a unique challenge for clinicians and justice systems. Drawing on Bronfenbrenner’s (1979) ecological systems theory, this study explored clinicians’ perspectives on the barriers to treatment engagement and completion for young people who have sexually offended in the Australian context. Semi-structured interviews were conducted with clinicians who provided or facilitated treatment for young people who had sexually offended (N = 22). Two major …

Strategies To Optimize Skill Acquisition And Prevent Skill Decay For The Air Transport Clinician, Mckayley Green, Aaron J Lacy, James L Li, John E Schneider

2020-Current year OA Pubs

No abstract provided.

Effect Of Melatonin On Alleviating Chilling Injury In Cold-Stored ‘Kensington Pride’ Mangoes: A Comparative Evaluation Of Long Vs Short Dip Time, Mekhala Dinushi Kananke Vithana, Hafiz Muhammad Shoaib Shah, Mahmood Ul Hasan, Zora Singh

Research outputs 2022 to 2026

Mangoes (Mangifera indica L.) are notably susceptible to chilling injury (CI) when stored below 13 °C. This temperature threshold is too high for extended storage. Therefore, the influence of postharvest immersion in melatonin (MT) (50, 75, 100 µmol L^{− 1}) for 120 min on CI in ‘Kensington Pride’ mangoes kept at 5 ± 1 °C for 21 or 28 d was investigated. The most effective MT concentration was 75 µmol L^{− 1} causing 36.3% reduction in CI incidence compared to control. To facilitate adoptability in commercial practice, the influence of 120 min vs. 5- and 3-min immersions …

Effect Of Molybdenum Content On The Microstructure And Tribological Properties Of Ti-Nb-Cu Alloys Produced By Lpbf Additive Manufacturing, Lei Qin, Shengfeng Zhou, Jianbo Jin, Huan Yang, Kunmao Li, Cheng Deng, Yujie Yuan, Seyed Reza Elmi Hosseini, Laichang Zhang

Research outputs 2022 to 2026

Obtaining excellent wear resistance is critical for titanium alloys used as orthopedic implants. In this study, the β-type Ti-35Nb-5Cu- x Mo alloys (Ti355 x , x = 0, 1, 2, and 4 wt%) were fabricated by the laser powder bed fusion (LPBF) method. In the meantime, the influence mechanism of Mo content on the microstructure and tribological properties was systematically investigated. The results show that all the LPBF-produced Ti355 x alloys exhibit a bimodal columnar-equiaxed grain structure, with Mo refining columnar grains and suppressing the α″ phase formation. Moreover, increasing the Mo content reduced the relative density, while enhancing the …

Efficacy And Effectiveness Of Melatonin For The Management Of Musculoskeletal Pain: A Systematic Review And Meta-Analysis Of Placebo And Active Controlled Trials, Kangchao Wu, Ting Him Ho, Paula R. Beckenkamp, Michelle Hall, Hanzhi Zhang, James Puterflam, Karin Due Bruun, Jianhua Lin, Christopher Gordon, Ron Grunstein, Manuela L. Ferreira, Paulo Ferreira

Research outputs 2022 to 2026

Melatonin may provide benefits for managing musculoskeletal (MSK) pain, and this review evaluated its efficacy and effectiveness on pain intensity and sleep quality. We searched 6 databases from inception to April 2025 and included randomized controlled trials in people with chronic or postoperative MSK pain reporting pain or sleep outcomes. Comparators included placebo or active controls (eg, analgesics). Random-effects meta-analyses were performed using mean differences with 95% confidence intervals. Subgroup analyses were conducted by comparator type. Sensitivity analyses included only low-risk studies. Certainty of evidence was assessed using GRADE. Twenty-three studies (2028 participants) were included. For people with chronic MSK …

Environmental, Social And Governance (Esg) Drivers Of Sustainability Transitions In Sub-Saharan Africa: Why One Size Does Not Fit All, Emmanuel Kwaku Manu, Bismark Asante, Gabriel Eweje

Research outputs 2022 to 2026

Despite growing emphasis on sustainability transitions in developing economies, evidence remains limited on how environmental, social and governance (ESG) conditions shape sustainability outcomes in sub-Saharan Africa (SSA). This study examines the environmental, social and governance drivers of sustainability transition performance across 39 SSA countries over the period 2000–2023. A composite sustainability transition performance index (STPI), constructed from renewable energy consumption and reverse-coded energy intensity indicators, is used to capture transition performance. A multi-method panel framework is employed to examine direct, conditional, nonlinear and dynamic relationships. The findings show that environmental pressures, particularly carbon intensity and energy use, consistently weaken sustainability …

Exploring A Potential Link Between Personality Traits, Sexual Assault Attitudes And The Propensity To Create Deepfake Pornography, Lorna Marns, Ross Hollett

Research outputs 2022 to 2026

Deepfake pornography represents a rapidly expanding form of image-based sexual abuse (IBSA), yet little is known about the psychological factors that predict individuals’ willingness to create such material. This study examined whether rape myth acceptance (RMA) and Dark Tetrad traits (Machiavellianism, narcissism, psychopathy, and sadism) predicted heterosexual men’s proclivity to create deepfake pornography. Using an online self-report survey of 213 heterosexual men recruited from an Australian university and the surrounding community, participants completed measures of RMA, dark personality traits, and hypothetical scenarios assessing the likelihood of creating deepfake pornography. Hierarchical regression models showed that RMA attitudes that minimise or excuse …

Feasibility Of A Clinical Supervision Training Program For Mental Health Nurses: A Mixed-Methods Study, Jennifer Hamilton, Lesley Barr, Marie Boulianne, Irene Ngune, Julie Sharrock, Debbie Massey

Research outputs 2022 to 2026

Background: Clinical supervision is widely recognised as a valuable method of workplace support and professional development. Effective supervision requires clinical supervisors to be trained on theory and practice. Oftentimes, training is interdisciplinary and may not address discipline-specific needs. Aim: This study evaluated the implementation of a clinical supervision training program developed specifically for mental health nurses and informed by community and consumer involvement. Methods: A convergent parallel mixed-method design was used. A purposeful sample of 18 mental health nurses who completed the training program participated. Data collection included the Acceptability, Feasibility, Appropriateness Scale and open-ended qualitative survey responses. Quantitative data …

Participatory Systems Modeling In Implementation Research: Exploring Benefits, Facilitators, And Future Needs, Natalie Riva Smith, Jennifer L Cruz, Jessica Gannon, Stephanie Mazzucca-Ragan

2020-Current year OA Pubs

BACKGROUND: Implementation science increasingly uses participatory systems modeling (PSM) approaches to handle the complexity inherent to implementation science issues. To support the process of integrating PSM with implementation science, we aimed to understand and explicate the benefits, facilitators, and future needs of applying PSM to implementation research.

METHODS: We conducted semi-structured qualitative interviews with 23 researchers (n = 18) and practitioners (n = 5). We purposively sampled participants and identified additional participants through recommendations. Interviews were inductively analyzed. Key concepts were identified via iterative description, comparison, and conceptualization.

RESULTS: Engagement with people in the system was typically focused in earlier …

Gwas Meta-Analysis Provides New Insights Into Uveal Melanoma Risk, Matthew D’Mellow, Huanwei Wang, Jane M. Palmer, Kari Hemminki, Colleen M. Cebulla, Aaron B. Beasley, Nikolaos E. Bechrakis, Antonia L. Pritchard, Karin W. Wadt, Peter A. Johansson, Lenha Mobuchon, Samantha Barlow, Kelly Brooks, Timothy Beckman, Catherine M. Olsen, Sunil K. Warrier, Lindsey Byrne, Helen Kalirai, Colette Mustard, Nathan Ingold, Asta Försti, Timothy Isaacs

Research outputs 2022 to 2026

Objective: The aim of this research is to identify germline genetic variants that predispose to uveal melanoma (UM) using data from nine studies involving 5839 individuals with UM (3853 novel) and 349,863 healthy controls. Methods: Five novel UM genome-wide association studies (GWAS) were performed and included for meta-analysis with four previously published UM GWAS. A fixed-effects inverse-variance weighted (IVW) meta-analysis was performed by combining data from these nine UM case-control cohorts. A follow-up transcriptome-wide association study (TWAS) was conducted to identify candidate target genes at UM risk loci. Genetic correlations with melanoma-related phenotypes were measured to elucidate UM’s genetic architecture. …

Implementation Of Risk Prediction And Stratification Approaches For Ageing Populations In Australian Healthcare: A Systematic Review, Leanne Greene, Jacob Brain, Belinda Brown, Claire V. Burley, Elissa Burton, Zhongyang Guan, Bronwyn Myers, Katherine Ride, Serena Sabatini, Mario Siervo, Abay Woday Tadesse, Eugene Yee Hing Tang, Blossom C.L. Stephan, Jennifer Dunne

Research outputs 2022 to 2026

Despite widespread development of prognostic risk stratification tools, their implementation in Australian healthcare remains poorly characterised. This review identified tools implemented for adults aged ≥40 years and examined their real-world use. Following PRISMA and SWiM guidelines, MEDLINE, EMBASE, Web of Science, PsycINFO, and CINAHL Plus were searched from inception to 20th February 2026. Eligible studies reported implementation of a risk stratification tool in Australian healthcare and health, functional, or implementation outcomes. The Mixed Methods Appraisal Tool assessed study quality. Of 7115 records screened, 21 studies were included across primary care, hospitals, residential aged care, and community services. Interventions included electronic …

Is A Fear Of Death Keeping You Awake At Night? Death Anxiety Predicts Insomnia Through Nightmare Severity, Rachel E. Menzies, Jessie Brown, Mitchell Turner, David Cunnington, Malisa Burge, Ian C. Dunican, Hailey Meaklim

Research outputs 2022 to 2026

The fear of death (death anxiety) is a risk factor for various mental health conditions. Death anxiety has been theorized to elicit physiological arousal and worry and is empirically associated with attachment insecurity, each of which has been linked to disrupted sleep. However, limited research has explored the relationship between death anxiety, nightmares and insomnia. We examined the relationship between death anxiety and insomnia, as well as attachment style as a potential moderator, and nightmare severity as a possible mediator. Five hundred and fifteen adults completed an online survey; 70% were female, and 89% resided in Australia. Regression analyses revealed …

Kinship Care And Aboriginal Children With Disabilities In Out-Of-Home Care: “My Boy, I Was His Voice”, Jocelyn Jones, Juliet Brook, Sasha Moodie, Richard Chenhall, Robyn Williams, Cathy Garlett, Katiska Davis, Alison Gibberd, Ben Harrap, Bridgette Mcnamara, Melissa O'Donnell, Sandra Eades

Research outputs 2022 to 2026

Background: Aboriginal and Torres Strait Islander children with a disability are over-represented in child welfare systems worldwide. Despite this, little is known about their involvement with the Australian child protection system or their lived experiences. Method: Led by Indigenous researchers and methodologies, qualitative findings from yarning sessions with 46 kinship carers across Western Australia informed this research. This research is part of the Indigenous Child Removals WA (I-CaRe WA) project. Results: Difficulty accessing disability assessments and diagnoses for children resulted in a lack of access to disability support services and missed opportunities for early intervention. Priority areas for improvement included …

Leading With Purpose: Uncovering The Impact Of Inclusive Leadership And Meaningful Work On Work Passion, Azadeh Shafaei, Mehran Nejati

Research outputs 2022 to 2026

Work passion is a critical driver of employee wellbeing, engagement, and performance; however, organisations often struggle to cultivate it effectively. Understanding what fosters work passion is essential because it not only deepens insight into employee motivation but also enables organisations to enhance passion and its positive outcomes. Despite growing interest, research has primarily focused on individual traits, leaving the role of organisational and leadership factors under-explored. To bridge this gap, we extend the Employee Work Passion Appraisal (EWPA) framework by examining how inclusive leadership and meaningful work influence employees’ work passion and whether the psychological authenticity climate mediates these relationships. …

Let’S Make The Change: Addressing The Knowledge Gaps And Building Confidence In Teaching Aboriginal Perspectives For Pre-Service Teachers, Sarah Booth, Libby Jackson-Barrett, Mary Anne Macdonald, Renae Isaacs-Guthridge, Sian Bennett

Research outputs 2022 to 2026

Teaching Aboriginal perspectives and Aboriginal students by non-Indigenous teachers can feel daunting; however, this need not be the case. This study focuses on two frameworks that can be used to motivate pre-service teachers to feel more confident in teaching Aboriginal perspectives even when starting with trepidation in this area. To explain further, this study explored the impact an Aboriginal Contexts in Education unit had on pre-service teachers’ readiness to teach Aboriginal students and Aboriginal curriculum. Through two frameworks pre-service teachers were exposed to a range of Aboriginal perspectives through Aboriginal educators, authors, and resources, and spoke of their appreciation of …

Machine Learning Derived Abdominal Aortic Calcification Is Associated With Physical Frailty In Community-Dwelling Adults: The Uk Biobank Imaging Study, Abadi K. Gebre, Marion Mundt, Elsa Dent, James Webster, Afsah Saleem, Syed Zulqarnain Gilani, Yuandan Zhang, Cassandra Smith, Parminder Raina, John P. Kemp, William D. Leslie, John T. Schousboe, Nicholas C. Harvey, Joshua R. Lewis, Marc Sim

Research outputs 2022 to 2026

Clinical cardiovascular disease (CVD) is often present in frail individuals. However, it remains unclear whether subclinical CVD, e.g., abdominal aortic calcification (AAC), is associated with frailty. This study investigated the cross-sectional relationship between AAC scored using a validated machine learning model (ML-AAC24) and physical frailty. 49,081 participants from the UK Biobank Imaging Study without atherosclerotic CVD (ASCVD) diagnosis were included. ML-AAC24 extent was categorised as low, moderate and high, based on established severity categories. Physical frailty was based on a modified Fried’s frailty phenotype comprising weak hand grip strength, slow walking speed, weight loss, exhaustion, and physical inactivity. Individuals with …

Maternal Prebiotic Supplementation Modifies Associations Between Intrapartum Antibiotics And Infant Allergy, Summer V.M. Walker, Thomas R. Sullivan, Rachelle A, Pretorius, Nina D'Vaz, Johnny Lo, Johan Garssen, Jeffrey A. Keelan, Desiree Silva, Susan L. Prescott, Claus T. Christophersen, Debra J. Palmer

Research outputs 2022 to 2026

Background: Prebiotics promote growth of beneficial gut bacteria, whereas antibiotics can disrupt the microbial balance, reduce diversity, and potentially cause gut dysbiosis. This investigation aimed to determine whether antibiotic use before, during, or after birth altered the risk of infant allergic disease outcomes within a maternal prebiotic dietary supplementation trial. Methods: Maternal participants were allocated to consume daily prebiotics (galacto-oligosaccharides and fructo-oligosaccharides) or placebo (maltodextrin) powder from 18 to 20 weeks' gestation until 6 months postnatal. All infants had a family history of allergic disease. Maternal and infant antibiotic use was prospectively collected monthly throughout the trial intervention period, and …

Measuring Mental Health Promoting Behaviours: Development And Psychometric Properties Of A Danish Act Belong Commit-Mental Health Promoting Behaviours (Abc-Mhpb) Scale, Line Nielsen, Ziggi Ivan Santini, Malene Kubstrup Nelausen, Carsten Hinrichsen, Frederik Schou-Juul, Vibeke Jenny Koushede, Robert J. Donovan, Charlotte Bjerre Meilstrup

Research outputs 2022 to 2026

Background: The Act Belong Commit-ABCs of Mental Health campaign is the world’s first comprehensive, population-wide, community-based initiative to promote mental health. In response to a growing demand for valid tools to monitor mental health promoting behaviours, this study presents the development and psychometric evaluation of the ABC-Mental Health Promoting Behaviours (ABC-MHPB) scale in a Danish population-based sample. Methods: A 10-item scale was developed, based on the ABC framework, to assess mental health promoting behaviours. A total of 119,221 randomly selected participants aged 18+ filled out an electronic survey, including the scale to measure the underlying construct of mental health promoting …

Measuring Teachers’ Beliefs In Their Capacity To Use Differentiated Instruction In Their Classrooms: Development, Validation And Confirmation Of A Self-Efficacy Scale, Kathryn Gibbs, Stuart Woodcock, Nicole Dargue, Leah Le, Eunjae Park, Tom Porter, Gemma Scarparolo

Research outputs 2022 to 2026

The purpose of this study was to develop, validate and confirm a scale to gain a better understanding of teachers’ beliefs in their capacity to use differentiated instruction in their classrooms. Differentiation is an effective approach to teaching, designed to enable equitable learning opportunities for every student. Teachers are recommended to differentiate aspects of teaching, instruction, learning, assessment and the learning environment due to the increasing student heterogeneity within classrooms worldwide. Emerging literature has suggested that teacher self-efficacy may influence how teachers use this teaching approach. It is unknown if there is an existing scale that measures teachers’ self-efficacy when …

Multilevel Nested Paradoxes: How Organizational Leaders Interpret And Manage Tensions, Uzma Batool, Muhammad Mustafa Raziq, Peter Galvin, John Lewis Rice

Research outputs 2022 to 2026

Organizational actors face multiple paradoxical tensions that are not only intertwined with one another but also nested across different levels of the organizational hierarchy. Despite their importance, little is known about how such paradoxical tensions are interpreted and managed by organizational leaders. To explore this phenomenon, we conducted semi-structured interviews and collected multilevel data from 38 respondents, including corporate executives, team leaders, and managers in the Pakistani telecommunications sector. Through an interpretive phenomenological analysis of participants’ lived experiences, we developed a multilevel nested paradox model. This model revealed four paradoxes nested both within and across levels: task efficiency and employee …

Multi-Objective Hydro-Thermal Optimization Of Spiral Conformal Cooling Channels Using A Kriging-Cfd Framework, Soroush Masoudi, Barun K. Das, Majid Tolouei-Rad

Research outputs 2022 to 2026

This study presents a surrogate-based computational framework for the thermo-hydraulic optimization of spiral conformal cooling channels (CCCs) used in injection moulding applications. Sixteen design configurations were generated using Latin Hypercube Sampling and evaluated through CFD simulations to determine cooling time and pressure drop. Based on the simulation data, a Universal Kriging surrogate model was developed to describe the nonlinear relationships between channel diameter, helix pitch, channel-to-surface distance, and the resulting thermo-fluid performance. The predictive capability of the surrogate model was evaluated using leave-one-out cross-validation. The model showed excellent agreement for pressure drop prediction (R² ≈ 0.99) and good predictive accuracy …

Negotiating Relationships With Food, The Body, And Physical Activity: Who Is The Healthiest Of Them All?, Valeria Varea, Victoria Evans, Dawn Penney, Eibhlish O'Hara

Research outputs 2022 to 2026

Healthy eating and regular exercise are things that many people aspire to, mainly for health reasons. However, these practices can be complex given broader societal discourses. This paper aims to critically interrogate the social conditions and discursive formations that underpin everyday exercisers’ relationships with food, the body, and physical activity by using biopower and biopedagogies as a theoretical approach, and healthism as a set of discourses. Photo elicitation interviews with vignettes were conducted with nine participants who were regular exercisers. We constructed three different scenarios from the interview data and the theoretical approach: 1. Anna: A performance-driven, health compliant, private …

Meta-Analysis Of Dna Methylation Aging Signatures In 17 Human Tissues, Macsue Jacques, Kirsten Seale, Sarah Voisin, Anna Lysenko, Robin Grolaux, Bernadette Jones-Freeman, Severine Lamon, Mandhri Abeysooriya, Itamar Levinger, Carlie Bauer, Adam P. Sharples, Aino Heikkinen, Elina Sillanpaa, Miina Ollikainen, Cassandra Smith, James R. Broatch, Navabeh Zarekookandeh, Linn Gillberg, Ida Blom, Jesse R. Poganik, Mahdi Moqri, Vadim N. Gladyshev, Matthew Taper, Cassandra Malecki, Sean Lal, Nathalie Saurat, Steve Horvath, Andrew Teschendorff, Nir Eynon

Research outputs 2022 to 2026

Epigenetic changes, in particular DNA methylation, accumulate with age across different tissues, but whether these changes follow consistent patterns across different organs remains poorly understood. Here we show, through a meta-analysis of more than 15,000 human methylation profiles spanning 17 tissues, that aging produces both conserved and tissue-specific epigenetic signatures. We identify systemic shifts in methylation levels, increases in methylation variability, and growing molecular disorder across tissues. Network analysis revealed tightly connected gene clusters that are not modified by beneficial interventions, alongside a more modifiable cluster linked to NAD⁺ metabolism, supporting NAD⁺ as a potential therapeutic target in …

Optimizing The Size And Siting Of Distributed Generation In Unbalanced Distribution Systems With Multi-Objective Reptile Search Algorithm, Pema Dorji, Chimi Pelden Dorji, Stefan Lachowicz, Octavian Bass

Research outputs 2022 to 2026

This paper presents the Multi-Objective Reptile Search algorithm for identifying ideal rating and location of distributed generation in unbalanced grids, focusing on minimizing power losses, total costs, and carbon emissions. The proposed methodology integrates DIgSILENT PowerFactory and Python platforms to evaluate unbalanced IEEE distribution feeders under varying power factor conditions. The results demonstrate that optimal DG configurations involve strategically positioning multiple units to enable both active and reactive power injection, significantly improving overall system performance across multiple objectives and voltage deviation index. The analysis identifies an optimal PF range between 0.75 and 0.89, with unity power factor operations yielding suboptimal …