Digital Commons Network^™

Infant Sensory Gating And A Developmental Cascade To Autistic Traits And Anxiety, Rebecca F Schwarzlose

2020-Current year OA Pubs

Disruptions to the infant sensory environment can have lasting effects on neural response properties and behavior in both humans and animals. Recent work has begun to highlight an additional factor in infant sensory experience: differences in inhibitory signaling and sensory gating. Converging work from human and animal studies has begun to implicate a developmental cascade by which impaired sensory gating during a sensitive period of neonatal neurodevelopment promotes a phenotype of sensory over-responsivity, autistic traits, anxiety, and other psychiatric challenges. In this Review, I propose a model for this developmental cascade and highlight how differences in infant sensory responsivity represent …

This Land Is Our Land: Creating Abortion Safe-Havens In Federal Enclaves Using The Nondelegation Doctrine, Callie Fucarino

American University Journal of Gender, Social Policy & the Law

In a post-Dobbs world, the legal status of abortion care is in the hands of the states. Healthcare providers and people seeking abortion care must either take legal risks or betray their morals and oath to care for their patients to follow the law in certain restrictive states. What remains in flux is the status of abortion rights on federal lands. There is currently no federal law that criminalizes abortion, but many states prohibit it. Within some states that have restricted abortion, there lie federal enclaves—certain specified land that the United States government owns, where federal law controls. At first …

Fundamental Rights Betrayed: How Pregnancy Exclusions In Advance Directive Statutes Silence Pregnant People’S Wishes, Molly Hill

American University Journal of Gender, Social Policy & the Law

INTRODUCTION: In 2013, Marlise Muñoz collapsed at her home and was rushed to the hospital, where the doctors informed her family that she had suffered a pulmonary embolism and was now brain-dead. Marlise had previously expressed to her family that she never wished to be kept on life support if she was left brain-dead, so her family wanted to honor her wishes. However, despite her irreversible brain death, because Marlise was fourteen weeks pregnant, Texas law required that her body remain on life-sustaining treatment until her fetus became viable. Her body lay in the hospital hooked up to machines against …

Anything But Endo: Diagnostic Buck-Passing In Endometriosis Diagnosis, Rita Dexter, Megan Kitts, Heather Welty, Melanie Jeske

Center for Medical Ethics and Health Policy Staff Publications

People living with endometriosis, a disease in which tissue similar to the lining of the uterus grows elsewhere in the body, often experience prolonged diagnostic journeys because of symptom variability, normalisation of period pain and other symptoms, and lack of awareness of the condition. In this article, we analyse the endometriosis diagnostic journey through the lens of epistemic injustice. Drawing on in-depth interviews with 52 people living with endometriosis in the United States, we introduce the concept of diagnostic buck-passing to characterise the phenomenon wherein individuals who seek treatment for their symptoms end up stuck in a cycle of seeing …

Putting The L In Elsi: Legal Methods For Bioethics Research, Anya E R Prince, Benjamin Berkman, Donald Ford, Dov Fox, Christi Guerrini, Amy Koopmann, Natalie Ram, Jessica L Roberts, Kayte Spector-Bagdady, Sonia Suter

Center for Medical Ethics and Health Policy Staff Publications

Lawyers and law professors are increasingly involved in interdisciplinary scientific teams and grant research to answer ethical, legal and policy questions related to biomedical topics. Yet, the methods that lawyers use to conduct legal research and analysis are not always familiar to scientists and social scientists conducting peer review of a proposed project with legal aims or a publication reporting a legal study. To better facilitate interdisciplinary ethical, legal, and social implications collaboration, there is a need to better explain how legal research methodologies can provide robust tools to address a range of nuanced biomedical questions. This paper explores …

Characteristics And Outcomes Of Patients With Hematologic Malignancies Hospitalized With Respiratory Viral Infections, Zulfiqar A Lokhandwala, Brenna Park-Egan, Ravneet Waraich, Colleen A Mcevoy, Andrew P Michelson, Alice F Bewley, Lynne Strasfeld, Rachel Cook, Brandon Hayes-Lattin, Catherine L Hough, Patrick G Lyons

2020-Current year OA Pubs

BACKGROUND: Respiratory viral infections in patients with hematologic malignancies or hematopoietic stem cell transplants (HCTs) are associated with increased morbidity and mortality. However, the hospital presentations and courses of these infections remain under-described.

METHODS: We performed a multicenter retrospective cohort study of hospitalized patients with hematologic malignancy or HCT at 2 comprehensive cancer centers between January 2019 and June 2023. We included all patients with acute viral respiratory infection (identified based on a constellation of test results and objective physiology), comparing clinical presentations, care processes, and patient outcomes across pathogens; the primary outcome was the composite of hospital death or …

Numerical Modeling Of Climate Change Impacts On Transportation Embankments, Amr Morsy, Mamata Sapkota, Emma Varela, Odalys Portillo

Mineta Transportation Institute

Embankments are essential components of transportation infrastructure, providing crucial support for long stretches of highways, railways, and other routes in California and around the world. Clay embankments are susceptible to weather-related deterioration processes that can gradually compromise their stability and, in some cases, lead to unexpected failures. Climate change, along with the associated shifts in weather patterns, is projected to adversely impact the weather-related deterioration processes, leading to exacerbated failures and/or shorter service life. Additionally, climate change is projected to increase the frequency of extreme precipitation events, leading to an increase in embankment failure potential. This study evaluated (1) the …

Scoring Equitable Transit: A Data-Driven Framework For Affordable Transit-Oriented Development In California, Ahoura Zandiatashbar, Anton Rozhkov, Stephanie Nemet, Atticus Washington, Mounashree Prasanna

Mineta Transportation Institute

Transit-Oriented Development (TOD) is a cornerstone of California’s climate and land use policy, promising walkable, compact neighborhoods near high-quality transit. However, these benefits are not always distributed equitably. This study introduces a scalable framework for identifying and scoring Affordable Transit-Oriented Development (A-TOD) across the state’s High-Quality Transit Areas (HQTAs). The goal is to equip policymakers, planners, and housing agencies with tools to evaluate station areas based on their physical form, affordability, and equity outcomes. Using a 1.5-mile network-based pedestrian buffer around over 66,000 transit stations, the research team developed a three-stage clustering and scoring system. Station areas were classified by …

Workforce Development Academy For Youth, Hassan Hashemian

Mineta Transportation Institute

To address the need for a diverse workforce in the 21st century and create an awareness of the career paths and opportunities that exist in the transportation industry, the College of Engineering, Computer Science, and Technology at the California State University, Los Angeles (CSULA) has created the Workforce Development Academy for Youth (WDAY). The goal of this program is to build a pipeline of diverse, well-qualified young professionals for the transportation industry. The program works with high school students and teachers to offer academic courses, basic skills, workforce readiness training, internships, extracurricular activities, and career placements to prepare students and …

Preparing For Long-Acting Technologies: A Multistate Analysis Of Prep Persistence And Hiv And Sti Lab Coverage Among Oral Prep Initiators In St. Louis, Missouri (2014-2021), Lindsey M Filiatreau, Rupa Patel, Kate Curoe, Ashley Underwood, Joseph Cherabie, Elvin H Geng, Aditi Ramakrishnan, Rachel Presti, Aaloke Mody

2020-Current year OA Pubs

BACKGROUND: Engagement in pre-exposure prophylaxis (PrEP) care and routine screening for HIV and sexually transmitted infections (STIs) is critical to realizing the full benefits of this HIV prevention strategy.

METHODS: We enrolled a cohort of individuals seeking PrEP services in two clinics in Missouri, an Ending the HIV Epidemic priority state, from June 2014 to November 2021. We used electronic health record and survey data to explore outcomes in the 2 years following linkage to care using multistate methods. We assessed transitions between eight mutually exclusive care states differentiated by receipt of a prescription, lab coverage status, and retention. We …

Intraoperative Neurophysiological Monitoring In Full-Endoscopic Cervical Endoscopic Ulbd, Miles Hudson, Sarah Esposito, Mark M Zaki, Simon M Glynn, Osama N Kashlan, John Ogunlade, Chandan Krishna, Joshua Bakhsheshian, Christoph P Hofstetter

2020-Current year OA Pubs

No abstract provided.

The Cognitive-Affective Social Processing And Emotion Regulation (Casper) Model, M Catalina Camacho, Elina Deshpande, Michael T Perino

2020-Current year OA Pubs

Humans are intensely social creatures. It is therefore not surprising that many psychiatric disorder criteria include social dysfunctions; however, overlapping presentations and diverse, complex etiologies make treating social dysfunctions difficult. Here, we introduce the Cognitive Affective Social Processing and Emotion Regulation (CASPER) model. CASPER integrates research from social psychology, cognitive neuroscience, and developmental science to describe how real-world social processing unfolds and is associated with differing psychiatric social cognitive neurophenotypes. Briefly, social processing can be broken down into the following cognitive steps: identifying relevant social cues, attending to related cues, interpreting cues, and adjusting behavior appropriately. Each of these steps …

Frontline Aspiration Versus Stent Retriever Thrombectomy For M2 Occlusions: Insights From The Star Registry, Michael Gaub, Joshua Osbun, Et Al.

2020-Current year OA Pubs

BACKGROUND: Recent trials have furthered uncertainty regarding the endovascular benefit for medium vessel occlusions (MeVO). Stent retrievers (SR) were employed in the first attempt in most interventional arm participants. We sought to compare outcomes in acute MCA M2 occlusions between frontline aspiration and SR, and to delineate procedural and anatomical covariates associated with differential treatment effect.

METHODS: Retrospective analysis of a multicenter stroke thrombectomy cohort identified cases of MT for M2 occlusions. Unmatched and propensity score-matched (PSM) cohorts were generated comparing frontline aspiration to standalone and combined SR. The primary outcome was functional independence (mRS 0-2) at 90 days. Recanalization, …

Transforming Cancer Nursing Care Through Academic-Clinical Practice Partnerships, Eileen Danaher Hacker, Constance Johnson, Asha Demla

International Nursing Research Congress (INRC)

Background: Academic-clinical partnerships in nursing are vital to foster scholarly inquiry, strengthen quality improvement, promote evidence-based practice, and advance research initiatives. Hosting a collaborative conference strengthens academic-clinical practice partnerships and creates a platform for communicating findings.

Purpose: This report details the program evaluation of the inaugural Transforming Cancer Nursing Care Through Quality Improvement, Evidence-Based Practice, and Research Conference hosted jointly by an academic medical center and school of nursing.

Methods: Findings from a study that identified and prioritized the real-world challenges faced by cancer nurses served as the initial catalyst for convening the conference. The academic-clinical practice partnership provided the …

Enhancing Offshore Wind Resource Assessment Through Neural Network-Based Hf Radar Data Analysis, Nikolas Martzikos, Matthew Craven, David Walker, Daniel Conley

School of Engineering, Computing and Mathematics

The increasing demand for offshore wind energy underscores the need for accurate wind speed estimation to support the design and operation of offshore wind farms. High-Frequency Radar (HFR), a widely used remote sensing technology in oceanographic research, offers promising potential for wind resource assessment, particularly in areas where conventional measurements are limited. This study explores the application of artificial neural networks (ANNs) for offshore wind speed prediction using HFR-derived data, addressing key challenges in model development and training. A key feature of this approach is the use of a decade-long dataset from the Celtic Sea, off the southwest UK coast, …

Next-Generation Virtual Environment Training For Cybersecurity In The Maritime Logistics Industry: A Position Paper, Tyler Cheng, Rory Hopcraft, Kimberly Tam, Ji-Jian Chin

School of Engineering, Computing and Mathematics

The maritime logistics industry is the most dependent on it in the modern world, yet it is not well protected against cyber risks. Recently, the maritime industry has been transitioning into industry-specific tech, and threats of cyberattacks are increasing as the adoption of technology and automation continues. One of the most effective methods to protect industries and ships from such security incidents, is to train seafarers to mitigate and handle such incidents. However, to the best of our knowledge, we did not find anything that addresses this gap. This article will present the idea and benefits of using virtual environments …

Fault Tolerant Adaptive Control Under Actuator Saturation For Robot Manipulators, D. J. López-Araujo, N. Alvarez-Jarquin, P. Borja, A. T. Becker

School of Engineering, Computing and Mathematics

In practice, actuators inherently have natural limitations that are often overlooked by theoretical control strategies, such as bounded output and discrepancies between calculated and actual responses. Consequently, reliable control techniques must be employed to ensure safe and dependable operation. We propose an adaptive control law for global regulation in the case of partial loss of effectiveness due to input faults. The proposed control strategy maintains the system at the desired configuration while accounting for the physical limitations of the actuators. Additionally, it is suitable for dealing with unknown parameters in the vector of gravitational forces, making it robust to these …

Angle-Based Formation Stabilization And Maneuvers In Port-Hamiltonian Form With Bearing And Velocity Measurements, Ningbo Li, Pablo Borja, Arjan Van Der Schaft, Jacquelien M.A. Scherpen

School of Engineering, Computing and Mathematics

This paper proposes a port-Hamiltonian approach for angle-based formation stabilization and maneuvers using bearing and velocity measurements with an underlying triangulated Laman graph. The corresponding port-Hamiltonian controller is designed using virtual couplings on the errors of angle constraints in angle space. Then, the angle constraints and agent actuators are mapped by the constraint Jacobian, which can be applied to other formation constraints. In addition, to avoid unavailable distance terms in the control law, an estimator is designed based on port-Hamiltonian theory and the property that energy is coordinate-free for different sensor modalities using bearing and velocity measurements, which permits our …

Scope 3 Carbon Emissions Assessment For Manufacturing Smes, Kourosh Halat, Stephen Childe, Nick Golding, John Summerscales

School of Engineering, Computing and Mathematics

This paper addresses the challenges facing managers of Small-andMedium-Size Enterprises (SMEs) when conducting environmental sustainability assessment at the value chain level, particularly Scope 3 Greenhouse Gases GHG) emissions. The paper investigates issues related to data availability and data quality for Scope 3 assessment and identifies dimensions of Scope 3 reliability.Utilising a series of in-depth case study analyses with SMEs in the south-west of England, UK, the paper fills a gap in supply chain sustainability research by identifying practical challenges. The findings show that SMEs encounter persistent difficulties in assessing emissions associated with purchased goods and services and downstream activities linked …

Usable Authentication: Are We There Yet?, Nathan Clarke, Steven Furnell

School of Engineering, Computing and Mathematics

With technology increasingly embedded in everyday life, the demand for secure and usable authentication methods has never been greater. Traditional password-based systems continue to dominate, despite well-known usability and security challenges. This paper explores the evolution of user authentication technologies, from secret knowledge and tokens to biometrics and emerging approaches such as Passkeys. It critically evaluates the extent to which usability has been achieved, identifying both successes—such as biometrics integrated into smartphones—and persistent issues, including inconsistent guidance, ecosystem dependence, and accessibility barriers. Drawing on academic and commercial developments, the discussion highlights the growing burden on users who must authenticate across …

Rapid Electrochemical Biosensor With Enhanced Accuracy And Repeatability Using Pyrene Nhs Ester Modified 3d Graphene Electrodes, S. Nazir, D. Jenkins, G. Pan

School of Engineering, Computing and Mathematics

A consistent and reproducible chemical modification of the transducer interface is essential to ensure effectiveimmobilization of bioreceptors, thereby improving the sensitivity and reproducibility of biosensors. Althoughnotable progress has been made in fabricating graphene-based biosensors, the effects of surface biofunctionalization on sensing performance remain not fully understood. This study shows that combining threedimensional (3D) graphene foam electrodes with a straightforward, single-step surface biofunctionalizationmethod is key to enhancing the performance of graphene-based biosensors. Specifically, it presents a single-stepapproach to functionalize the 3D graphene foam (Gii-Sens) with 1-pyrenebutyric acid N-hydroxysuccinimideester (Pyrene-NHS ester). Electrochemical techniques, including cyclic voltammetry (CV) and differential pulsevoltammetry (DPV), confirmed …

From Predictions To Explanations: Explainable Ai For Autism Diagnosis And Identification Of Critical Brain Regions: 18th International Joint Conference, Biostec 2025, Kush Gupta, Amir Aly, Emmanuel Ifeachor, Rohit Shankar

School of Engineering, Computing and Mathematics

Autism spectrum disorder (ASD) is a neurodevelopmentalcondition characterized by atypical brain maturation. However, the adaptationof transfer learning paradigms in machine learning for ASD researchremains notably limited. In this study, we propose a computeraideddiagnostic framework with two modules. This chapter presents atwo-module framework combining deep learning and explainable AI forASD diagnosis. The first module leverages a deep learning model finetunedthrough cross-domain transfer learning for ASD classification. Thesecond module focuses on interpreting the model’s decisions and identifyingcritical brain regions. To achieve this, we employed three explainableAI (XAI) techniques: saliency mapping, Gradient-weighted Class ActivationMapping, and SHapley Additive exPlanations (SHAP) analysis.This framework demonstrates that …

Biocompatibility Of Silver And Hydroxyapatite Antimicrobial Nanocoatings On Titanium Alloy Dental Implants With Human Gingival Fibroblasts, S Morgan, R D Handy, V M Salih, R N Salaie, C J Tredwin, A Besinis

School of Engineering, Computing and Mathematics

OBJECTIVES: Peri-implantitis compromises soft and hard tissues around dental implants, often leading to implant failure. Antibacterial nanocoatings offer a promising infection control strategy, but maintaining biocompatibility is essential. This study investigated, through a range of assays and analytical techniques, the biocompatibility of antimicrobial silver and hydroxyapatite (HA) nanocoatings applied to titanium implants with human gingival fibroblasts (HGFs).

METHODS: Silver and hydroxyapatite nanocoatings were applied to the surface of titanium alloy specimens using electroplating, deposition and sintering techniques. The biocompatibility of the nanocoatings with HGFs was assessed by measuring cell metabolic activity (alamarBlue), lactate dehydrogenase (LDH) release, collagen production (Sircol assay), …

Heat Transfer From A Partially Buried Circular Cylinder In Oscillatory Flow, H. Thomas, R. Stuhlmeier, A. G.L. Borthwick, S. Michele

School of Engineering, Computing and Mathematics

With the growing abundance of man-made cylindrical structures located on or close to the seabed, it is important to be able to assess their potential environmental impact. Herein, a model is presented of the viscous-thermal boundary layer in the vicinity of a circular cylinder resting on, or partially buried in, an otherwise flat seabed. To model the influence of wave-induced motions near such a cylinder, we assume oscillatory flow in which the water particle displacements are small with respect to the cylinder radius. A perturbation expansion is utilised to derive solutions of the boundary layer equations, leading to analytical solutions …

The Development Of A Midwifery Specific Tool To Identify The Barriers And Enablers To Change Within The Midwifery Setting, Sara Davis

Theses: Doctorates and Masters

Despite being well-positioned to identify service gaps and propose improvements, many midwives lack the knowledge, skills, confidence, or tools to effect practice change. Implementation science (IS) offers a structured approach to moving evidence-based innovations into practice; however, existing IS theories, models, and frameworks do not reflect the unique context of midwifery practice. The first step in the intentional implementation of an evidence-based practice innovation is to conduct a context assessment to identify factors that may facilitate or impede its uptake. There are numerous evidence-based checklists for this, but none capture all the influences on midwifery practice environments.

In this study, …

The Experience Of Homelessness Among Older Adults In Bhutan - A Narrative Inquiry Study, Phuntsho Om

Theses: Doctorates and Masters

A shift in the demographics of homelessness started to occur in the 1900s, with a significant increase in the number of middle-aged or elderly men and women being recognised as a part of the homeless population. The rising urgent global concern of homelessness of older adults necessitates a deeper understanding of the lived experience and holistic well-being of these marginalised adults. This thesis aimed to explore the phenomenon of homelessness of older adults in Bhutan, which is an often neglected topic in both national and international gerontological research.

Employing narrative inquiry within the constructivist approach as articulated by Pino Gravidia …

Enhancing Deep Reinforcement Learning With Expert Demonstrations For Mobile Robot Navigation In Unstructured Off-Road Environments, Dulitha Dabare

Theses: Doctorates and Masters

Advancements in the field of Deep Learning has ushered in a boom in autonomous navigation research. Most of the work being conducted in this space, however, has focused on on-road urban navigation scenarios, with unstructured outdoor terrain navigation receiving much more limited attention. Given the wide range of applications that exist for legged and wheeled ground robots in off-road environments in areas such as agriculture, mining and disaster recovery, there is a growing need for research work to improve the navigational capabilities of mobile robots deployed in these challenging environments.

A promising candidate for application to these navigation challenges in …

Emotional Coding In Wolfgang Amadeus Mozart’S Music: The Influence Of Text-Driven Musical Patterns, Antonio Toppi

Theses: Doctorates and Masters

This thesis investigates the phenomenon of emotional coding in the music of Wolfgang Amadeus Mozart (1756–1791), with particular attention to the ways in which text-driven musical patterns influence both vocal and instrumental works. The study draws on 18th-century theories of key characteristics, musical-rhetorical figures, and topoi, compositional devices that carried emotional implications for contemporary listeners. These codes are first examined in two of Mozart’s operas, Le Nozze di Figaro (KV492) and Don Giovanni (KV527), where the setting of text to music provides a framework for associating compositional choices with emotion. Findings from the analyses are then applied to three contemporaneous …

Emerging From The Cocoon: Strategies To Assist The Classical Violinist Develop Improvisational Fluency In A Range Of Musical Styles, Judith A. Iddison

Theses: Doctorates and Masters

This autoethnographic practice-led research project documents the journey of expanding my classical violin practice with the aim of developing improvisational fluency in a range of musical styles. Building upon findings and strategies outlined in my honours thesis, which centred on the artistry of Australian cross-genre violinist Shenzo Gregorio (Shenton Gregory), this doctoral study is underpinned by an iterative cyclic process of critical observation, reflection and analysis and an examination of literature.

Knowledge gained through one-on-one, aural-based, practical violin-improvisation instruction with Gregorio was applied within collaboration with the evolving string ensemble, Sign of Four. Further, combining this tuition and collaboration with …

Patient Experiences Of Receiving Home-Based Immunotherapy Infusions - A Constructivist Grounded Theory Study, Patricia Ann Cook

Theses: Doctorates and Masters

Context: The treatment of cancer and chronic health conditions has been greatly revolutionised via intravenous immunotherapy infusions. Demand, both globally and in Australia, is increasing due to several factors including aging and increased populations, subsequent increases of cancer cases, new immunotherapy indications and increased survival rates.

In Perth, Western Australia, a private service provider commenced delivering a home based immunotherapy infusions model of care as a hospital substitution service provider in 2013 and the service has now been extended across Australia. The safety and efficacy of home-based infusions have been well documented in research, and an increasing number of patients …