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2026

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Spell Of Forty Small Failings, Erin B. Ehren Jan 2026

Spell Of Forty Small Failings, Erin B. Ehren

Theses and Dissertations

Spell of Forty Small Failings is a collection of images and writings that draws from an unruly range of literary forms, academic disciplines, and religious cannons in order to address the Divine—all that which exists on account of the phenomena of what it is to see and be seen: to hear and be heard: to touch and be touched: to know and be known, and through that knowing proceed beyond mediation. I wrote this thesis for me in the hopes that all along I was writing for you.


Dietary Acculturation, Dietary Inflammatory Potential, And Metabolic Syndrome Among Immigrants In The United States: A Mixed-Methods Approach Using Nhanes And Qualitative Data, Esse G. Foka Nzaha Jan 2026

Dietary Acculturation, Dietary Inflammatory Potential, And Metabolic Syndrome Among Immigrants In The United States: A Mixed-Methods Approach Using Nhanes And Qualitative Data, Esse G. Foka Nzaha

Theses and Dissertations

Background and Objectives: Immigrants in the United States undergo acculturation — a process of sociocultural and behavioral adaptation to the host country. Increasingly, behavioral adaptations have been associated with cardiometabolic health and chronic disease risk. Metabolic syndrome (MetS), a cluster of conditions including abdominal obesity, elevated blood pressure, impaired fasting glucose, elevated triglycerides, and reduced HDL cholesterol, is a major risk factor for type 2 diabetes mellitus, cardiovascular diseases and other chronic diseases, including cancer. Despite the growing immigrant population in the U.S., the role of diet and dietary acculturation in MetS development remains poorly understood in this population. This …


24-H Circadian Rest-Activity Rhythms And Physical Frailty In Older Adults: A Biopsychosocial Perspective On Sex Differences And Social Capital, Jisu Kim Jan 2026

24-H Circadian Rest-Activity Rhythms And Physical Frailty In Older Adults: A Biopsychosocial Perspective On Sex Differences And Social Capital, Jisu Kim

Theses and Dissertations

Physical frailty is a prevalent geriatric syndrome characterized by age-related decline across multiple physiological systems. Physical frailty is associated with an elevated risk of adverse health outcomes, including chronic disease progression and all-cause mortality, representing a significant and growing public health concern. Disrupted circadian rest-activity rhythms (RARs) are increasingly recognized as clinically meaningful markers of physical frailty in older adults. However, the extent to which biological sex and social determinants of health (SDoH), particularly social capital, contribute to or modify the associations between RARs and physical frailty remains underexplored.

Therefore, this dissertation summarizes the existing literature on age-related changes in …


Mediator: Ornament As A Visual Language Of The Transcendent, Selma Fejzullaj Jan 2026

Mediator: Ornament As A Visual Language Of The Transcendent, Selma Fejzullaj

Theses and Dissertations

Adolf Loos’s declaration that “ornament is a crime” defined modernist design, establishing a legacy that dismisses ornamentation as wasteful and regressive. This research questions that legacy by repositioning aesthetics as a divinely grounded value, inspired by the Qur’anic vision of Paradise. In this celestial realm, beauty is not wasteful but a manifestation of divine perfection. Conceptually, the project reclaims ornament as a vital tool for contemplating metaphysical themes. Materially, it reimagines glass, shifting it from modernist "radical honesty" to a medium of layered depth. Recombining traditional Islamic ornamentation practices such as Girih and Chaharbagh, the project evokes the Qur’anic vision …


Centering Individual Well-Being In Learning Environments: Academic Stress, Psychological Safety, And Digital Discourse, Rachel Niemira Namboodri Jan 2026

Centering Individual Well-Being In Learning Environments: Academic Stress, Psychological Safety, And Digital Discourse, Rachel Niemira Namboodri

Theses and Dissertations

Statement of Problem

How do we guide students through school while supporting their emotional and psychological health? This question lies at the heart of contemporary educational psychology research, as growing evidence demonstrates that students’ academic achievement and psychological well-being are deeply intertwined with their experiences in learning environments (Baumeister & Leary, 1995; Edmondson & Lei, 2014; Gopalan & Brady, 2020; Song et al., 2024; Spencer, 1995; Walton & Cohen, 2011). Decades of scholarship affirm that students’ academic achievement and psychological well-being are deeply intertwined with how they experience schools, classrooms, peers, teachers, and institutional structures (Baumeister & Leary, 1995; Edmondson …


A Mathematical Frameworks For Singular, Nonlinear Phenomena: Applications To Nematocyst Firing And Inhomogeneous Nls With Coulomb Potential, Abdulrahman Alharbi Jan 2026

A Mathematical Frameworks For Singular, Nonlinear Phenomena: Applications To Nematocyst Firing And Inhomogeneous Nls With Coulomb Potential, Abdulrahman Alharbi

Theses and Dissertations

Nematocysts are specialized cellular organelles found in all cnidarians, including corals and jellyfish, as well as in some single-celled protists such as dinoflagellates. These organelles display remarkable diversity in morphology and function, playing roles in prey capture and defense. The firing of a nematocyst is one of the fastest accelerations in nature, yet the underlying physical mechanisms remain not fully understood. In this work, we address key questions: how sufficient force is generated to overcome the fluid boundary layer, whether fluid–structure interaction models can reproduce observed dynamics, and what mechanisms trigger discharge.

Our research investigates models based on osmotic pressure …


Waxing And Waning: Hidden Interiors Of Grassroots Expression, Asmita Baskar Jan 2026

Waxing And Waning: Hidden Interiors Of Grassroots Expression, Asmita Baskar

Theses and Dissertations

Concealed interiors historically emerged from necessity in response to dominant systems around surveillance, control, and visibility. These hidden spaces carefully regulated access, cultivated intimacy, and enabled self-expression within grassroots groups and marginalized communities. Operating free from surveillance and in contrast to surrounding architectural and urban systems, these concealed spaces were not formally “interior designed”, yet they reveal how communities activate the interiors they encounter to retain agency.

Scholarship on grassroots resistance is largely examined through sociology, anthropology, psychology, or political science, with limited literature directly linking interiority, interior design, and resistance within covert spaces. This thesis addresses the gap in …


To Put It Simply, Men Are Like Kites., Yangyang Zhang Jan 2026

To Put It Simply, Men Are Like Kites., Yangyang Zhang

Theses and Dissertations

This thesis explores the performative professionalization of So-called “emotional mentors” on mainstream Chinese social media platforms, specifically Douyin (the Chinese version of TikTok). and its impact on the contemporary Chinese emotional landscape. Through a series of undercover investigations in livestreams, I analyze the rhetorical tactics and professional jargon used by these “Gurus” to attract and monetize vulnerable audiences.

The research highlights a critical paradox: while promising emotional clarity, these methods from “Love Gurus” often corrupt the sincerity of intimate bonds, resulting in significant emotional labor and self-doubt for Female. The project aims to demystify this predatory industry and its role …


Internalizing Symptoms In Lgbtq+ Young Adults: Understanding The Roles Of Social Support And Resilience To Social Stigma, Chloe M. Sobolewski Jan 2026

Internalizing Symptoms In Lgbtq+ Young Adults: Understanding The Roles Of Social Support And Resilience To Social Stigma, Chloe M. Sobolewski

Theses and Dissertations

LGBTQ+ young adults are at increased risk of adverse mental health outcomes including internalizing symptoms. The current study seeks to better incorporate strengths when modeling internalizing symptoms outcomes in LGBTQ+ young adults. The present study is secondary analysis of data collected as part of a three-wave longitudinal study. LGBTQ+ young adults (N = 250) completed baseline questionnaires assessing resilience to social stigma, types of perceived social support (i.e., family, friend, significant other), and internalizing symptoms. Moderation models were not practically or statistically significant; however, covariates (i.e., age, socioeconomic standing, and childhood basic needs) stood out in their significant contribution in …


Vitality: Wellness For Female Collegiate Athletes, Kristin Beach Jan 2026

Vitality: Wellness For Female Collegiate Athletes, Kristin Beach

Theses and Dissertations

Vitality is a wellness center for female collegiate athletes. It is rooted in female oriented design strategies for comfort, recovery, and wellbeing. This project aims to provide an inclusive environment in which women within the VCU athletics department can come and support their health and wellbeing.  Spaces include physical therapy, academic support, movement studios, gathering lounge, locker room, private therapy, and grab and go food options. This program aims to provide spaces that support the busy schedule of a collegiate athlete, while using design strategies that enhance social, mental, and physical wellbeing while visiting. Located in a historic sauers building, …


Not Just Cheap Labor: A Critical Mixed Methods Assessment Of Working Learner Supervision To Advance Equitable Work-Integrated Learning, Jonathan D. Fuller Jan 2026

Not Just Cheap Labor: A Critical Mixed Methods Assessment Of Working Learner Supervision To Advance Equitable Work-Integrated Learning, Jonathan D. Fuller

Theses and Dissertations

This study examines how supervisory relationships shape the quality of on-campus student employment (OCSE) as a work-integrated learning (WIL) experience, with particular attention to the experiences of working learners (i.e., student employees). Situated in response to growing student demand for meaningful, career-relevant work opportunities in college, the study investigates how universities can leverage existing OCSE roles to expand access to WIL. Using a mixed methods explanatory social justice design, the research integrates working learner responses (N = 478) to the Student Supervisor Support Measure with interviews of students and supervisors in relationships characterized as both supportive and cross-identity.

Survey …


Maintaining Legitimacy While Managing Competition: Do Transplant Survival Ratings Affect Kidney Transplant Waitlisting?, Andrew Placona Jan 2026

Maintaining Legitimacy While Managing Competition: Do Transplant Survival Ratings Affect Kidney Transplant Waitlisting?, Andrew Placona

Theses and Dissertations

Statement of problem and objectives: Waitlisting is an essential step towards kidney transplantation among people with end-stage kidney disease (ESRD). There are no universal standards for waitlisting ESRD patients and how waitlists are managed in kidney transplant programs is opaque and under-studied. This study investigated whether the quality ratings of kidney transplant programs based on their one-year survival rates were associated with waitlist outcomes, including the number of waitlist additions, waitlist removals, the risk profiles of patients added or removed from a kidney transplant program’s waitlist, and whether market competition among kidney transplant programs attenuated these relationships.

Procedure followed: …


Examining Youth Ethnic Identity And Parental Familismo As Protective Factors Against Bicultural Stress And Internalizing Symptoms In Latino Youth, Daniella Olivares Jan 2026

Examining Youth Ethnic Identity And Parental Familismo As Protective Factors Against Bicultural Stress And Internalizing Symptoms In Latino Youth, Daniella Olivares

Theses and Dissertations

Adolescence is a critical developmental period marked by increased vulnerability to mental health challenges. For Latino adolescents living in the U.S., experiences of bicultural stress may heighten the risk for adverse mental health outcomes. However, cultural strengths–such as youth ethnic identity and parental familismo–may serve as protective factors. The current study examined whether youth ethnic identity and parental familismo moderated the relationship between bicultural stress and internalizing symptoms among a diverse sample of Latino youth in central Virginia. Latino adolescents (n = 60) completed measures assessing bicultural stress, ethnic identity, and internalizing symptoms, while parents (n = 60) reported on …


Synthesis Of Iso-Dityrosine, A Potential Biomarker Of Neurodegenerative Diseases, Brandon R. Knouse Jan 2026

Synthesis Of Iso-Dityrosine, A Potential Biomarker Of Neurodegenerative Diseases, Brandon R. Knouse

Theses and Dissertations

As the population of the United States continues to age, the prevalence of neurodegenerative disorders is rising, increasing the societal and clinical burden of diseases such as Parkinson’s disease and dementia-related conditions. Lewy Body Dementia (LBD), the second most common cause of dementia, shares underlying neuropathological features with Parkinson’s disease, including the aggregation of misfolded α-synuclein into Lewy bodies and Lewy neurites. Current diagnostic approaches rely heavily on cerebrospinal fluid biomarker analysis; however, significant overlap exists among biomarkers associated with Alzheimer’s disease and other neurodegenerative conditions, limiting diagnostic specificity. Emerging evidence suggests that oxidative modifications of α-synuclein, particularly the formation …


"It's The People, Not The Place:" Queering Shared Space In Richmond, Virginia, Kathleen Brown Jan 2026

"It's The People, Not The Place:" Queering Shared Space In Richmond, Virginia, Kathleen Brown

Theses and Dissertations

The intersection of queerness and planning is an understudied subject area that has implications for equity and access. Queer communities face real barriers to equitable access of resources that stem from a long history of legal, cultural, and economic marginalization. Experiences of shared spaces for queer groups and organizations is important to understand, as outward expressions of queerness are not always welcome in shared spaces, depending on sociopolitical context. Richmond, Virginia has a rich queer history both filled with challenges as well as examples of queer success and joy that makes it a prime case study selection.

This thesis utilizes …


The Mundo I Imagine, Angeliky Castrellon Jan 2026

The Mundo I Imagine, Angeliky Castrellon

Theses and Dissertations

My work investigates the human experience of belonging and how the force of displacement alters the perception of one's present and enables dissociation. After leaving my home and starting a new life overseas, coming back never felt the same; I couldn’t find peace and comfort anywhere. This made me create an imaginary world called “Mundo.” Shelters for the souls of the displaced, looking for comfort. As I became a graduate student in the Craft/Materials Studies department, my perspective widened, and my work itself answered a question for me: I want to be comfortable everywhere; how can my home be everywhere …


Loved Right: Encouraging The Responsible Adaptive Reuse Of Historic Buildings In The Information Age, Christie Chirinos Jan 2026

Loved Right: Encouraging The Responsible Adaptive Reuse Of Historic Buildings In The Information Age, Christie Chirinos

Theses and Dissertations

This research contributes to interior design scholarship by situating immersive virtual reality (VR) as an efficiency tool and an architectural visualization tool within adaptive reuse and historic preservation practice. Interior designers are increasingly tasked with mediating between cultural heritage, community stakeholders, regulatory constraints, and economic feasibility, in buildings that already exist. By positioning VR as a tool with utility across every stage of the design process, this study expands interior design research beyond material and spatial interventions to include storytelling and technological innovation as drivers for design decision-making. The work bridges interior design, preservation, and participatory planning, demonstrating how immersive …


What’S Sleep Got To Do With It? A Mixed Methods Exploration Of The Feasibility, Acceptability, And Initial Outcomes Of Group Cbt For Insomnia In Parkinson’S Disease, Claire M. Williams Jan 2026

What’S Sleep Got To Do With It? A Mixed Methods Exploration Of The Feasibility, Acceptability, And Initial Outcomes Of Group Cbt For Insomnia In Parkinson’S Disease, Claire M. Williams

Theses and Dissertations

Parkinson’s disease is a progressive neurodegenerative disease that is commonly associated with sleep disturbances, affecting up to 80 percent of individuals with Parkinson’s. Effective and accessible treatments for sleep problems in Parkinson’s disease remain limited. Cognitive Behavioral Therapy for Insomnia (CBTi) is a well-established, non-pharmacological treatment for insomnia but has been minimally studied in Parkinson’s populations. This study evaluated the feasibility, acceptability, and preliminary outcomes of a group-based CBTi intervention adapted for individuals with Parkinson’s disease. Participants engaged in a six-week group intervention that incorporated Parkinson’s-specific adaptations. Preliminary findings indicated that the adapted group CBTi intervention was generally feasible and …


Tuberculosis In Jim Crow Virginia, 1900-1972, Elizabeth Dooley Jan 2026

Tuberculosis In Jim Crow Virginia, 1900-1972, Elizabeth Dooley

Theses and Dissertations

Tuberculosis (TB) was a major public health concern in the United States, especially in the first half of the twentieth century. Transmission and treatment of the disease, which is spread between humans through close contact, was complicated by racial segregation laws in the South known as Jim Crow laws. Virginia subscribed to these laws, which played a role in how and where Black Virginians with TB could be treated. Segregated treatment facilities with an inadequate number of beds for the number of infected people and deaths in the state added to these complications of disease control and plan for eradication. …


Early Math Readiness And Later Achievement: A Longitudinal Study, Bailey Bontrager Jan 2026

Early Math Readiness And Later Achievement: A Longitudinal Study, Bailey Bontrager

Theses and Dissertations

The current body of literature provides much evidence that mathematics skills at the start of kindergarten are predictive of later mathematics achievement, and that students enrolled in early childhood education (ECE) programs are better prepared for mathematics at the start of kindergarten. However, the potential for children to develop mathematical skills prior to entering kindergarten relies on access to ECE programs and resources in families’ surrounding communities. Recent use of geospatial data collection techniques and measures of community resource availability have enabled researchers to examine specific localities for the ways in which community organizations and institutions support residents in particular …


Comparison Of Artificial Intelligence Vs Human Observer For Periapical Radiolucency Detection, Adam J. Pink Jan 2026

Comparison Of Artificial Intelligence Vs Human Observer For Periapical Radiolucency Detection, Adam J. Pink

Theses and Dissertations

Objective: The aim of this study was to assess the performance of an Artificial Intelligence (AI) program (OverJet AI) with that of experienced endodontic residents, endodontists, a radiologist, and dental students in detecting periapical radiolucencies using radiographic images.

Methods: One hundred and fifty periapical radiographic images were analyzed using the OverJet AI software to determine the presence/absence of a periapical radiolucency as well as the size (small 1-3mm, medium 4-6mm, and large 6+mm). The unaltered images were also evaluated by two endodontic residents, two practicing endodontists, an oral radiologist and two 4th year dental students.

Results: Agreement between the AI …


Endodontic Access Through Zirconia Crowns: A Comparative Evaluation Of 3d Guided Versus Free-Handed Techniques, Maryam Alrughaib Jan 2026

Endodontic Access Through Zirconia Crowns: A Comparative Evaluation Of 3d Guided Versus Free-Handed Techniques, Maryam Alrughaib

Theses and Dissertations

Objective:

Accessing canals through full-coverage zirconia crowns is challenging and may increase the risk of misdirection, excessive dentin removal, and prolonged chair time. Guided endodontic access has been proposed to improve efficiency and precision. This study compared the accuracy and time efficiency of guided versus free-hand endodontic access through zirconia restorations. The hypothesis was that guided access would enhance canal localization precision and significantly reduce access time.

Methods:

Thirty-two extracted maxillary premolars were restored with 1-mm–reduced monolithic zirconia crowns (3Y-TZP, Katana HTML, Kuraray, Japan) and mounted in Modupro models. Teeth were assigned to two groups (n = 16 each): guided …


Use Of Transcranial Magnetic Stimulation As An Assessment Of Corticospinal Excitability In Individuals With Persistent Postural Perceptual Dizziness, Elizabeth Cornforth Jan 2026

Use Of Transcranial Magnetic Stimulation As An Assessment Of Corticospinal Excitability In Individuals With Persistent Postural Perceptual Dizziness, Elizabeth Cornforth

Theses and Dissertations

Persistent postural-perceptual dizziness (PPPD) is a common, disabling, chronic vestibular disorder whereby individuals experience symptoms of non-vertiginous dizziness, unsteadiness, and sway or rocking that are present most hours of the day, most days of the week. Individuals with PPPD have been noted to have an increased burden of dizziness and reduced quality of life compared to other dizziness diagnoses. The cause of PPPD is not well understood which can lead to years of diagnostic testing, failed therapies, and poor symptom management. It is important to understand PPPD pathophysiology so that optimal treatment interventions can be developed for this disorder to …


Advancing Cybersecurity Through Userland Memory Forensics: From Runtime Analysis To Security Applications, Hala Ali Jan 2026

Advancing Cybersecurity Through Userland Memory Forensics: From Runtime Analysis To Security Applications, Hala Ali

Theses and Dissertations

Memory forensics has become a crucial component of digital investigations, particularly for detecting malware operating solely in system memory. As operating system vendors implemented kernel access restrictions, malware authors shifted to userland malware. However, existing memory forensics techniques have largely focused on kernel-level analysis, leaving userland runtimes insufficiently covered. This dissertation addresses this gap by expanding memory analysis capabilities across two distinct paradigms: interpreted and compiled runtimes. The first phase targets the Python runtime, developing automated recovery techniques that enable several security applications. For malware detection, these techniques extract critical forensic artifacts such as encryption keys and command-and-control configurations. For …


Class-Aware Early-Exit Networks For Efficient And Secure Edge Deployment, Mohammed Ayyat Jan 2026

Class-Aware Early-Exit Networks For Efficient And Secure Edge Deployment, Mohammed Ayyat

Theses and Dissertations

Edge devices increasingly run high-stakes machine learning workloads under strict latency, power, memory, and communication constraints. Deep neural networks provide the accuracy needed for tasks such as network intrusion detection, health monitoring, autonomous sensing, and human activity recognition, but conventional inference executes the same computational path for every input. Early-exit neural networks reduce average inference cost by allowing confident samples to terminate before the final layer. However, existing early-exit systems are largely class-agnostic: they allocate computation according to confidence or uncertainty, without considering that different output classes may carry different operational urgency. This dissertation develops class-aware early-exit inference, a framework …


Nanomagnet Based Reservoir Computing And Quantum Control, Fahim F. Chowdhury Jan 2026

Nanomagnet Based Reservoir Computing And Quantum Control, Fahim F. Chowdhury

Theses and Dissertations

Conventional CMOS scaling has driven remarkable advances in computing but faces increasing physical and energy constraints, motivating alternative computing paradigms that integrate memory and computation while improving energy efficiency. Nanoscale magnetic systems offer a promising platform for such approaches because their intrinsic nonlinear dynamics and localized magnetic fields can support both classical and quantum information processing. This thesis investigates nanomagnetic systems for physical reservoir computing and, with primary emphasis, for localized quantum control of spin qubits.

The first part explores dipole-coupled nanomagnet arrays as physical reservoirs. Micromagnetic simulations demonstrate nonlinear dynamical behavior with high short-term memory and parity-check capacity, enabling …


Integration Of Whole Genome Sequence And Rna-Sequencing Data For Disease-Specific Phenotype Prediction, Leiliani M. Clark Jan 2026

Integration Of Whole Genome Sequence And Rna-Sequencing Data For Disease-Specific Phenotype Prediction, Leiliani M. Clark

Theses and Dissertations

Breast cancer is a heterogeneous disease driven by complex genomic and transcriptomic alterations, making accurate phenotype prediction a challenging task. Recent advances in genomic foundation models and representation learning provide new opportunities to extract biologically meaningful features directly from sequencing data. The objective of this study was to develop and evaluate a multimodal framework integrating whole genome sequence (WGS) and RNA sequencing (RNA-Seq) embeddings for breast cancer classification. DNABERT-2, a DNA foundation model, was evaluated for its ability to generate genomic representations from The Cancer Genome Atlas breast cancer (TCGA-BRCA) WGS data, and the impact of downstream fine-tuning on embedding …


Local Lung Delivery Of Ginkgetin For Therapeutic Intervention In Lung Fibrosis, Cimone L. Richardson Jan 2026

Local Lung Delivery Of Ginkgetin For Therapeutic Intervention In Lung Fibrosis, Cimone L. Richardson

Theses and Dissertations

Lung fibrosis (LF) is a progressive, irreversible pathological condition in the lungs that is ultimately fatal. Current drug treatments (nintedanib, pirfenidone, and nerandomilast) slow disease progression but cause significant systemic adverse effects due to oral administration. Transient receptor potential vanilloid 4 (TRPV4), a mechanosensitive ion channel, may play a role in LF progression and represent a novel anti-LF target. Ginkgetin (GKT), a natural biflavonoid, is a potent TRPV4 inhibitor with anti-inflammatory and antioxidative properties. Local lung delivery could achieve high local lung concentrations while minimizing systemic exposure. Accordingly, this project evaluates GKT's therapeutic intervention efficacy in LF via local lung …


Partisan Local Media And Corporate Voluntary Disclosures: Evidence From Sinclair Acquisitions, Ming Li Jan 2026

Partisan Local Media And Corporate Voluntary Disclosures: Evidence From Sinclair Acquisitions, Ming Li

Theses and Dissertations

I investigate the impact of local media’s political orientation on firms’ voluntary disclosure, exploiting the acquisitions of local TV stations by Sinclair Broadcast Group, a conservative media conglomerate. Drawing on the media bias theory and implementing a staggered difference‐in‐differences design, I find that the local partisan media affects management earnings forecasts. Specifically, Conservative-leaning CEOs in designated market areas (DMAs) affected by Sinclair’s acquisitions forecast more optimistically, increasing forecast frequency and inflating forecasted earnings. The impact is stronger if the DMAs are more Liberal-leaning before the acquisitions and when firms have weaker corporate governance. I also find that the stock market …


Discrete Cell Signaling Differences Cause Female-Dominant Il-33 Responses In Mast Cells, Tania D. Maldonado Jan 2026

Discrete Cell Signaling Differences Cause Female-Dominant Il-33 Responses In Mast Cells, Tania D. Maldonado

Theses and Dissertations

Many allergic diseases are more common and severe in women than in men. A key component of allergic inflammation is IL-33, a cytokine released by epithelial cells after allergen exposure. Because mast cells are a central early responder in allergic disease and are activated by IL-33, we investigated sex differences in mast cell responses to IL-33. We first found that male mast cells expanded poorly in standard RPMI-based culture media containing phenol red, which has estrogenic properties. Male cells also responded poorly to IL-33 when cultured with in media containing phenol red. In contrast, female mast cells expanded 3-fold less …