Digital Commons Network^™

Silver(I) And Copper(Ii) Complexes Of 1,10-Phenanthroline-5,6-Dione Inhibit Sporothrix Brasiliensis Azole-Resistant Clinical Isolates, Laís Cavalcanti Dos Santos Velasco De Souza, Nathália Faria Reis, Lucas Martins Alcântara, Simone Cristina Pereira Brito, Pamella Macedo De Souza, Zaida Maria Faria De Freitas, Ingrid De Souza Sousa, José Rodrigo Santos Silva, Ricardo Luiz Dantas Machado, Héctor Manuel Mora-Montes, Lucimar Ferreira Kneipp, Malachy Mccann, Michael Devereux, André Luis Souza Dos Santos, Andréa Regina De Souza Baptista

Research Outputs: 2025-Present

Background. Sporothrix brasiliensis is the principal etiological agent responsible for cat-transmitted zoonotic sporotrichosis, which is currently the most prevalent mycosis in South America—especially in Brazil—and is increasingly being reported in other regions. While itraconazole is the standard treatment, its use is limited by hepatotoxicity, high cost, and emerging reports of reduced susceptibility. Complexes of 1,10-phenanthroline-5,6-dione (phendione) with transition metals have previously shown promise as antifungal agents against bacteria, parasites, yeasts and filamentous fungi. This study investigates the in vitro and in vivo antifungal properties of [Cu(phendione)3](ClO4)2.4H2O (Cu-phendione) and [Ag(phendione)2]ClO4 (Ag-phendione) against S. brasiliensis isolates from domestic felines in endemic regions. …

Influence Of Beamwidth, Gain Stability, And Antenna Element Spacing On Aoa Accuracy In Ieee 802.15.4z Uwb Systems, Hossein Raghib Hokmabadi, Wasi Ur Rehman Khan, Patrick Mcevoy, Max James Ammann

Research Outputs: 2025-Present

Precision is a crucial requirement in indoor localization, and the industrial sector increasingly demands technologies that provide both high accuracy and low cost. This work presents a hardware-based evaluation of dual-antenna arrays using an IEEE 802.15.4z-compliant UWB angle of arrival (AoA) development kit to assess antenna performance in terms of phase difference of arrival (PDoA)/AoA linearity. Four antenna types: 1) printed monopole; 2) CPW-fed slot; 3) stacked dielectric resonator antenna (DRA); and 4) dual-layer microstrip patch are evaluated on channels 5 and 9, with measurements performed in a calibrated anechoic chamber under controlled conditions. The results show that wide beamwidth …

Contrasting Environmental Drivers Of Shiga Toxin-Producing Escherichia Coli (Stec) O157 And O26 Serogroups In Surface Water And Private Groundwater Supplies Of A Karst Agricultural Catchment In Western Ireland, Robert J. Hynes, Zina Alfahl, Louise O'Connor, Florence De Bock, Paul D. Hynds, Jean O'Dwyer, Liam P. Burke

Research Outputs: 2025-Present

Study Region: This study was conducted in the karstic Black River sub-catchment in western Ireland, where well-draining soils and rapid groundwater recharge promote strong surface-groundwater connectivity and increase the vulnerability of groundwater supplies to microbial contamination. Study Focus: This year-long study assessed the prevalence and environmental drivers of Shiga toxin-producing Escherichia coli (STEC) O157 and O26 in surface waters and groundwater wells from May 2023 to May 2024. Nineteen sites (5 river sites, 14 groundwater wells) were sampled fortnightly. Detection of O157- and O26-associated genes was performed using enrichment-free low-volume filtration with quantitative PCR. Logistic regression identified climatic and anthropogenic …

Discipline With Due Process: Constitutional Safeguards For Student Speech After Plaintiff A, Sarah Stich

Missouri Law Review

When fifteen-year-old Louie posted a TikTok video criticizing his school’s disciplinary policies from his bedroom, he faced a month-long suspension despite having no notice of which policies he had violated. Across the country, Kaitlin shared a Snapchat criticizing her chemistry teacher with friends at a local coffee shop and faced expulsion with minimal opportunity to explain the context. In both cases, students received limited procedural protections before suffering severe academic consequences.

Contralateral Breast Cancer After Radiotherapy And Hormone Therapy In Two Cohorts Of Us Breast Cancer Survivors, Lene H S Veiga, Gretchen L Gierach, Susan A Smith, Rebecca M Howell, Matthew M Mille, Monjoy Saha, Rochelle E Curtis, Cody Ramin, Clara Bodelon, Heather Spencer Feigelson, Erin J Aiello Bowles, Diana S M Buist, Sheila Weinmann, Jacqueline B Vo, Choonsik Lee, Amy Berrington De Gonzalez

Faculty, Staff and Student Publications

Background: Radiotherapy increases contralateral breast cancer risk, while hormone therapy reduces it; their combined effects are unclear.

Methods: Data from two US retrospective cohort studies of 5-year breast cancer survivors (stage I-III, ages 20-84), Kaiser Permanente (KP, 1990-2012) and SEER (1990-2013), were analysed. Contralateral breast radiation doses were estimated for the KP cohort. Multivariable Poisson regression estimated relative risks (RRs) and excess relative risks per Gray (ERR/Gy), stratified by hormone therapy use.

Results: KP cohort (n = 9053) included 353 contralateral breast cancer cases (73% ER+); SEER cohort (n = 244,834) included 10,470 cases (72% ER+). Among women with ER+ …

Alternative Polyadenylation Signatures Distinguish Maladaptive Right Ventricular Remodeling In Pulmonary Hypertension: Implications For Rna-Based Diagnostics And Therapeutics, Janani Subramaniam, Venkata Jonnakuti, Scott D Collum, Sandra Martineau, Kai-Lieh Huang, Sandra Breuils-Bonnet, Andrea L Frump, Bindu H Akkanti, Jayeshkumar A Patel, Manish K Patel, Ismael Salas De Armas, Isabella N Lefebvre, Rajko Radovancevic, Elvin Blanco, Eric J Wagner, Igor Gregoric, Sriram Nathan, Biswajit Kar, Steeve Provencher, Sebastien Bonnet, François Potus, Hari Krishna Yalamanchili, Harry Karmouty-Quintana

Faculty, Staff and Student Publications

Increased pulmonary vascular pressures due to vascular remodeling, elevated vascular resistance, and vasoconstriction characterize Pulmonary Arterial Hypertension (PAH). The narrowing of the pulmonary arteries and obstruction of blood flow increase the Right Ventricular (RV) afterload, forcing the RV to undergo structural and functional changes. While adaptive remodeling leads to RV compensation by maintaining function, maladaptive remodeling leads to RV decompensation, characterized by worsening function and eventual failure. At present, there is no effective treatment for these patients as therapies for left ventricular failure are ineffectual, and there are no therapies specifically targeting the RV. Therefore, there is a clear need …

Preclinical Ischemic Stroke Multicenter Trials (Prism) Collective Statement: Opportunities, Challenges, And Recommendations For A New Era, Cenk Ayata, Philip M Bath, Anna M Planas, Stuart M Allan, Johannes Boltze, Ryan P Cabeen, Claire L Gibson, Marilyn J Cipolla, Marcio A Diniz, Stefano Fumagalli, Fahmeed Hyder, Raymond C Koehler, Arthur Liesz, Sarah K Mccann, Tim Magnus, Louise D Mccullough, Emily S Sena, Simone Beretta, Jaroslaw Aronowski, Francesca Bosetti, Clinton B Wright, Patrick D Lyden, Lauren H Sansing

Faculty, Staff and Student Publications

Preclinical stroke research faces a critical translational gap, with animal studies failing to reliably predict clinical efficacy. To address this, the field is moving toward rigorous, multicenter preclinical randomized controlled trials (mpRCTs) that mimic phase 3 clinical trials in several key components. This collective statement, derived from experts involved in mpRCTs, outlines considerations for designing and executing such trials. mpRCTs offer advantages such as increased sample sizes, robust statistical design, incorporation of heterogeneity, and standardized protocols, but they face challenges in finding the right balance between standardization and heterogeneity, appropriate stroke model selection, and outcome measures, as well as the …

Management Of Retropharyngeal Lymph Node Metastases In Thyroid Cancer, Isabelle Fournier, Ashwini Venkata Bandi, Sarah Hamidi, Priyanka Iyer, Naifa L Busaidy, Maria E Cabanillas, Ramona Dadu, Mimi I Hu, Steven G Waguespack, Ugur Nur Basmaci, Michelle D Williams, Mena Mansour, Maria Gule Monroe, Neil D Gross, Ryan P Goepfert, Nancy D Perrier, Victoria Banuchi, Jennifer R Wang, Anastasios Maniakas, Mark E Zafereo

Faculty, Staff and Student Publications

Background: Retropharyngeal lymph node (RPLN) metastases in thyroid cancer are rare, with optimal management underreported.

Methods: Retrospective study of consecutive thyroid cancer patients with RPLN metastases treated at MD Anderson Cancer Center between 2000 and 2024.

Results: One hundred and sixty-seven patients (75% differentiated, 21% medullary, 4% poorly differentiated thyroid cancer) were divided into three groups: active surveillance (AS) (13%), surgery (56%), and nonsurgical treatment (31%). In the AS group (median follow-up 2.3 years), RPLN metastases grew a median 3% (range: 0-56) or 0.02 cm (range: 0-0.7) per year. Surgical therapy included transcervical (73%), transoral robotic (14%), transoral (12%), and …

Blood Flow Regulates Metabolism In Hematopoietic Development, Pamela L Wenzel

Faculty, Staff and Student Publications

Blood flow modifies oxygen availability and biomechanical forces within the vasculature of the embryo as the hematopoietic system develops. The aorta-gonad-mesonephros (AGM) envelops the largest artery in the body and is a critical site for the emergence of hematopoietic stem cells (HSCs). Herein, I discuss the role of hypoxia-inducible factors (HIFs) and force as determinants of metabolism and fate determination. To address the effects of blood flow on hematopoietic development, I employ mouse embryo models and biomimetic culture. Real-time cell metabolic analyses show that oxygen consumption rates (OCR) and extracellular acidification rates (ECAR) are altered by flow in cultures of …

Host Modulation Therapy In Periodontitis: From Established Therapies To Emerging Technologies, Aonjittra Phanrungsuwan, Jiaqi Huang, Neeraja Dharmaraj, Alejandra Cobos Perez, Omid Veiseh, Simon Young, Chun-Teh Lee

Faculty, Staff and Student Publications

Periodontitis is a biofilm-induced chronic inflammatory disease, characterized by gingival inflammation and alveolar bone loss. According to a national survey, approximately half of the U.S. adults are affected by periodontal disease. To effectively prevent and treat periodontitis, it is essential to address its underlying causes. The primary etiological factors include polymicrobial synergy and dysbiosis of the oral microbiota, and a dysregulated immune response. The standard therapeutic approach, mechanical removal of biofilm through debridement, sometimes demonstrates limited efficacy, particularly in cases of severe periodontitis, which may require adjunctive or additional therapy. Emerging evidence indicates that periodontal tissue destruction is initiated by …

Streamlining Eligibility Assessment For Alzheimer’S Disease-Modifying Therapies: Prediction Of Mmse Scores Using The Digital Clock And Recall, Ali Jannati, Claudio Toro-Serey, Marissa Ciesla, Emma Chen, John Showalter, David Bates, Alvaro Pascual-Leone, Sean Tobyne

Faculty, Staff and Students Publications

           Introduction: The eligibility of anti-amyloid disease-modifying therapies (DMTs) and their integration into clinical practice in some institutions requires a specific range of Mini-Mental State Examination (MMSE) scores. Reliance on this pencil-and-paper psychometric instrument imposes operational burdens and risks of perpetuating health disparities, given the test's known educational and cultural biases. This study evaluates the efficacy of the Digital Clock and Recall (DCR™)-a rapid, FDA-listed digital cognitive assessment-to crosswalk to MMSE scores using machine learning, thereby offering a faster, scalable, and equitable mechanism for patient triage.

Methods: We conducted a retrospective analysis using data from the multi-site Bio-Hermes-001 (BH) study ( …

Discipling The Youth Through Preaching, Rodney Palmer

Faculty Publications

No abstract provided.

A Different Starting Point: Youth Discipleship For A New Generation, Rogelio Paquini

Faculty Publications

No abstract provided.

“I Don’T Always See A Future For Me Here”: Oppressive Political Pressures On Lgbtq+ College Students’ Well-Being, Jodi Linley, Olivia M. Copeland, Kathleen J. Buell, Cindy Ann Kilgo, Megan Pendleton, Alex C. Lange, N F. Tennessen

Journal of Queer and Trans Studies in Education

In recent decades, colleges have broadly supported LGBTQ+ students. Now, institutions have shuttered LGBTQ+ initiatives in response to political pressures, with little consideration for the effects on students. This study answers the question, what current policy factors do LGBTQ+ college students describe as affecting their well-being, and in what ways? We analyzed 426 responses from a multi-institution study of LGBTQ+ students. By and large, students feel anxious and fearful as they navigate the current climate. Our analysis illustrated numerous factors, from the President and his administration to states and general emboldened violence, and the real and potential consequences of those …

Applications And Challenges Of Utilizing Digital Pathology And Ai-Enabled Workflows In Clinical Trials, Manu Sebastian, Harsh Batra, Monika Lamba Saini, Staci Kearney, Lorcan Sherry, Serge Alexanian, Michael Cohen, William Weber, Joe Lennerz, Anil V Parwani

Faculty, Staff and Student Publications

This is a comprehensive review on current utilization and challenges of digital pathology adoption in clinical trials and aims to provide a broad view on its impact on pathology review processes in clinical trials. It provides an overview of current pathology review practices in clinical trials and unique advantages digital pathology adoption can offer. The key areas including existing workflows, use case scenarios in different disease areas in clinical trials, including but not limited to patient identification and pre-screening, and regulatory aspects have been described with relevance. In addition, the review delves into the integration of genomics, AI, image analysis, …

Reconsidering The Definition Of Triple-Negative Breast Cancer In The Immune Checkpoint Inhibitor Era: An Optimal Cut-Off Value For Hormone Receptor Percentage Of Her2-Negative Invasive Breast Cancer, Takeo Fujii, Toshiaki Iwase, Yu Shen, Jami Fukui, Naoto T Ueno

Faculty, Staff and Student Publications

The optimal cut-off values of estrogen receptor (ER) and progesterone receptor (PgR) expression to define the positivity of ER and PgR have been under discussion for over a decade but remain controversial. The American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) and the St. Gallen International Expert Consensus recommended that breast cancers with ≥1% of ER or PgR expression should be considered hormone receptor (HR)-positive tumors but ER/PR expression of 1% to 10% should be reported as HR-low positive; however, among HER2-negative disease, data on the overall benefit of adjuvant endocrine therapies for patients with HR-low positive disease is …

Digital Communication Strategies For Culinary Medicine In Cancer Prevention And Survivorship: Information-Seeking Habits And Content Preferences Of Online Cooking Media Among Adults Participating In Four Cancer Prevention And Control Cohort Studies, Margaret Raber, Sara Fares, Maria Vazquez, Larkin Strong, Carrie Daniel-Macdougall, Lorna Mcneill, Karen Basen-Engquist

Faculty, Staff and Student Publications

Introduction

Poor diet and excess weight have been linked to increased risk for at least 13 types of cancer. Culinary medicine utilizes experiential cooking skill development to improve individuals’ capacity for healthy eating. Digital communication strategies offer pathways for scalable culinary medicine interventions, but little research has explored how online cooking tools could be leveraged for cancer prevention messaging. We conducted a cross-sectional survey study exploring online cooking information-seeking habits and content preferences among participants in four cancer prevention and control cohorts to inform future digital culinary medicine interventions.

Methods

A cross-sectional survey study was conducted with a convenience sample …

Interventional Oncology: A Primer For Clinicians On The Role Of Ablation And Embolization For Solid Tumors, Mohamed E Abdelsalam, Kamran Ahrar, Rahul A Sheth, Ketan Y Shah, Steven Yevich, Varshana Gurusamy, Bruno C Odisio, Alda L Tam, Armeen Mahvash, Peiman Habibollahi

Faculty, Staff and Student Publications

Interventional radiology (IR) is a rapidly evolving medical field that combines advanced imaging with minimally invasive techniques for both diagnosis and treatment. Interventional oncology (IO), a subspecialty of IR, focuses on the minimally invasive, image-guided intervention for cancer and cancer-related conditions. IR plays an important and increasingly recognized role within the multidisciplinary care of patients with cancer, contributing meaningfully to diagnosis, therapy, and palliation. IO therapies, particularly tumor ablation and transarterial embolization, aim to target tumors directly while preserving surrounding healthy tissue. These therapies are increasingly supported by clinical guidelines and have shown favorable outcomes in cancers such as hepatocellular …

Researching A New Religious Phenomenon Of The Central Asia: Digital Sufism, Bekzhan A. Azhimov, Nurlan Kairbekov, Jolaman Bulan, Tussipkhan Imammadi

Occasional Papers on Religion in Eastern Europe

This study examines the emergence of digital Sufism as a modern spiritual phenomenon. It investigates the participation of Sufi groups on social media, the themes conveyed in their online sermons, and the ways their digital strategies compare with other Islamic organizations. The article further explores how Sufi orders navigate virtual environments, questioning whether they reveal elements of esoteric knowledge in these spaces. The notion of digital Sufism is presented as a lens for understanding how Sufi traditions integrate modern technology to widen the influence and relevance of their teachings. The research highlights how Sufism has adjusted to the challenges of …

Legislative Support Of Religious Policy In Ukraine Under Martial Law, Volodymyr Karpunets, Andrii Shevchuk, Oleksandr Bilchuk

Occasional Papers on Religion in Eastern Europe

The article examines the legislative framework of Ukraine's religious policy under the conditions of martial law caused by the full-scale armed aggression of the Russian Federation. The constitutional foundations of state-confessional relations are analyzed, particularly the provisions of Article 35 of the Constitution of Ukraine on freedom of conscience and religion, as well as Article 64, which provides for the possibility of temporary restrictions on religious rights under martial law. Key legislative acts are reviewed: the Laws of Ukraine "On Freedom of Conscience and Religious Organizations" (1991, with amendments in 2018 and 2019), "On the Legal Regime of Martial Law" …

From The History Of The Arrival Of The True Cross In Georgia, Giorgi Sosiashvili, Aleksandre Mgebrishvili Prof. Dr.

Occasional Papers on Religion in Eastern Europe

This article explores the complex historical and theological narratives surrounding the arrival of the True Cross—the Life-Giving Wood—in Georgia, as preserved in medieval Georgian chronicles and ecclesiastical writings. Drawing upon primary sources such as the Conversion of Kartli, the chronicles of Leonti Mroveli, Nikoloz Gulaberidze, and Arsen Ikaltoeli, as well as later accounts by Prince Teimuraz, Niko Dadiani, and Platon Ioseliani, the study reconstructs the multi-layered tradition of how fragments of the Holy Cross were brought from Byzantium to Kartli during the reign of King Mirian. According to these sources, Emperor Constantine the Great and Queen Helena dispatched to Georgia …

Preservation Of Architectural-Religious Heritage In Modern Ukraine, Olga Gold, Maksym Vasalatiy, Olga Dobrodum

Occasional Papers on Religion in Eastern Europe

This article examines answers to a number of pressing questions regarding the preservation of architectural heritage in the modern world: what philosophical views underlie the preservation of world heritage; and what is unique about the protection of religious architectural heritage. The architectural philosophy of religious buildings represents a complex of original concepts, both material and spiritual. The hypothesis consists of constructing an algorithm and mechanism for protecting cultural heritage from the perspective of the philosophy of architecture in post-war Ukraine. The preservation of historical and cultural heritage sites is one of the most complex areas of activity in the fields …

Frontmatter (Volume 46, Issue 4), Paul B. Mojzes

Occasional Papers on Religion in Eastern Europe

No abstract provided.

Eurasianism As The Ideological Foundation Of Putin's Russia: Protestant Dimensions., Pavlo Pavlenko

Occasional Papers on Religion in Eastern Europe

This article explores the ideological foundations of contemporary Putinist Russia, identifying Eurasianism as a primary socio-philosophical and geopolitical doctrine driving the Kremlin's imperial ambitions. The author traces the evolution of Eurasianism from its origins in "White émigré" circles to its current role as a conceptual bedrock for Russian fascism. A comparative analysis is provided between Eurasianism and the "Russian World" (Russkiy Mir) doctrine, highlighting their distinct approaches to ethnocentrism and continental unity. A significant portion of the study is dedicated to the "Eurasianization" of Protestant denominations within the Russian Federation, illustrating how these communities have been instrumentalized by the state …

Challenges Of The Religious Leadership In The Era Of Digitalization And Information-Communication Technology: The Example Of North Macedonia And Serbia, Vesna Zabijakin Chatleska, Marijana Maksimovic, Ruzhica Cacanoska

Occasional Papers on Religion in Eastern Europe

Abstract

The rapid development of the digitalization and the information-communication technology resulted in their wider use in the everyday professional and personal life, via various forms of its manifestation, such as, social networks, podcasts and artificial intelligence. The willingness and the capability of the religious leaders to accept information and communication innovations, and to adjust them to the existing specific structure of the religious communities, presupposes a strategic re-thinking of the religious practices and the relations with the believers in the online space. New technologies have enabled simpler and faster communication in religious communities, but with the use of digital …

Islamic Education And Imperial Governance: Kazakh Institutions In Turkestan (1867–Present), Mavluda Smanova

Occasional Papers on Religion in Eastern Europe

This article explores development of religious education among Kazakh populations within Turkestan Governor-Generalship from 1867 to the early twentieth century, placing it within wider context of imperial administration, Islamic intellectual heritage, and reformist initiatives. It contends that Islamic learning institutions were not merely shaped by colonial influence but operated as flexible and enduring systems deeply rooted in local social structures. Rather than suppressing these institutions, Russian imperial authorities adopted a policy of controlled integration, bringing them under administrative oversight while simultaneously promoting alternative educational models. This dynamic gave rise to diverse and negotiated educational landscape rather than a uniformly imposed …

The Phenomenon Of Professional Burnout Among Military Chaplains In Ukraine, Artem Makovskyi, Oleg Mateyuk, Oleksandr Bilovskyi, Anton Datskov, Dmytro Oleshko

Occasional Papers on Religion in Eastern Europe

The article presents a comprehensive study of the phenomenon of professional burnout among military chaplains in Ukraine in the context of their personal experience of being in extreme (combat) conditions. The relevance of the problem is due to the prolonged impact of combat operations, high psycho-emotional stress, and the special role of military chaplains in the system of moral and psychological support for Ukraine's security and defense sector. The theoretical and methodological basis of the study was the concept of professional burnout by K. Maslach, the provisions of the person-centered approach, and the theory of personal experience. The empirical study …

Frontmatter (Volume 46, Issue 5), Paul B. Mojzes

Occasional Papers on Religion in Eastern Europe

No abstract provided.

Socio-Psychological Portrait Of Muslim Women Who Joined Radical Religious Organizations, Akerke Sakbayeva, Nagima Baitenova, Zhuldyz Zhorabek, Assel Alimkhanova, Raimbek Zeinullin

Occasional Papers on Religion in Eastern Europe

This article examines the socio-psychological characteristics, motivations for radicalization, and the legal and social status of Muslim women who have joined radical religious organizations from gender and cultural studies perspectives. In recent years, the increasing involvement of women in violent extremist movements has intensified the need to investigate this phenomenon not only as a security issue, but also as a complex social, cultural, psychological, and gender-related phenomenon. The study analyzes both internal and external factors influencing the radicalization of women, including social marginalization, identity crises, emotional dependency, limited religious literacy, and perceptions of social injustice. Particular attention is given to …

Ideology And Law In Tension: The Macedonian Socialist Model Of Secularism And Its Constitutional Legacy, Aleksandar Spasenovski

Occasional Papers on Religion in Eastern Europe

This article examines the constitutional and ideological foundations of church–state relations in socialist Macedonia (1945–1990), situating them within the broader framework of socialist Yugoslavia. It argues that the Macedonian model of secularism was shaped by a structural tension between Marxist atheism as an official ideological doctrine and formal constitutional guarantees of freedom of religion. While constitutional texts affirmed separation and religious liberty, statutory regulation and political practice constrained the public role of religion and marginalized religious communities within the socialist legal order.

By analyzing ideological premises, constitutional provisions, and legislative instruments, the article identifies the defining paradox of the Yugoslav …