Digital Commons Network^™

Exploring The Las-Vict Principle Of Cryptocurrency Exchanges: A Belief–Action–Outcome Perspective, Cheuk Hang Au, Kevin K.W. Ho, Po Hsu Shieh, Kris M.Y. Law

Research outputs 2022 to 2026

Purpose – Cryptocurrency exchanges operate in a hyper-volatile, “wild west” environment, fundamentally challenging existing theories of FinTech success that were built for stable markets. The literature lacks a framework to explain how firms thrive amidst such extreme regulatory ambiguity and institutional distrust. This study resolves this theoretical puzzle by developing a new principle for success in nascent, high-stakes digital ecosystems. Design/methodology/approach – We conduct a multiple-case study of 14 leading cryptocurrency exchanges. Using the belief–action–outcome (BAO) logic as an analytical guide, we deconstruct the strategic actions that separate successful exchanges from failures, synthesising them into a new, empirically grounded framework. …

#Shoutyourabortion And Being Heard: The Affordances Of Hashtags For Feminist Counterpublics In Hostile Digital Atmospheres, Claire Fitzpatrick

Research outputs 2022 to 2026

This article critically explores counterpublic responses to the overturning of Roe v Wade and the intense contestation on Twitter (now X) between pro-abortion and anti-abortion advocates. Focusing on networked acts of deliberation, this study shows how #ShoutYourAbortion and #RoevWade facilitated the formation of defensive publics and Counterpublics. Hashtag feminism can enable affected groups to share experiences that are often marginalised by traditional media outlets, while witnessing and affirming similar experiences shared by others within their community. In this article, I examine the extent to which the collectivising hashtag #ShoutYourAbortion facilitates deliberation and listening in the context of polarising abortion debates …

Students’ Perspectives On Authentic Assessment: An Experiential Learning Framework For Work-Readiness And Employability, Claire Lambert, Madeleine Ogilvie, Stephanie Meek

Research outputs 2022 to 2026

Background: Universities are increasingly pressured to enhance graduate employability by embedding career readiness into curricula. Authentic, industry-based assessments offer a means to link theory with practice, yet little is known about their impact from the student perspective. Purpose: This study explored how an industry-based authentic assessment supports students’ transition to work through the lens of Experiential Learning Theory (ELT). Method: Using a qualitative design, guided-introspection questionnaires were completed by 20 marketing graduates 2 years after completing an industry-based social marketing project. Directed content analysis identified themes aligned with ELT stages and mechanisms of confidence, networks, and professional enculturation. Findings: Authentic …

Super-Resolution Learning Inspired Spectral-Spatial Correlation Network For Hyperspectral Target Detection, Jiaping Zhong, Yunsong Li, Jianxin Li, Yanzi Shi, Weiying Xie, Paolo Gamba

Research outputs 2022 to 2026

Hyperspectral target detection (HTD) aims at extracting targets from complex backgrounds while overcoming noise interference. Existing deep learning models for HTD usually suffer from low spatial resolution and unitary representation, especially in space-borne platforms. Super-resolution, as a critical technology to enhance the spatial details, could effectively address the aforementioned issue. To make super-resolution absolutely pose positive effects on target detection, this paper proposes an end-to-end novel super-resolution learning inspired spectral-spatial correlation network for hyperspectral target detection (SR-HTD) from the perspective of spatial and spectral regularization to achieve high-precision detection. Specifically, we designed a Spatial Correlation Aggregation (SCA) module inspired by …

Thorium Lung Burdens Of Norm Workers Revisited, Gregory S. Hewson, Martin I. Ralph, Marcus Cattani

Research outputs 2022 to 2026

Historical thorium bioassay data collected from Australian mine workers in the 1990s, including in vivo lung counting and thoron-in-breath (TIB) measurements, were re-evaluated using current dosimetric and biokinetic models. Revised daily thorium intakes from bioassay were compared with previous estimates to assess changes in the dose profile and potential implications for contemporary operations. Reanalysis revealed lower estimates of annual dose, including the number of workers assessed as exceeding 20 mSv. However, it was found that intakes derived from industry personal air sampling (PAS) underestimated intake by up to three-fold. This study determined that sensitive bioassay techniques, such as TIB using …

Academic Librarians And Information Literacy Practice In An Age Of Mis/Disinformation, Nicole Johnston, Yerbury, Maureen Henninger

Research outputs 2022 to 2026

This paper presents findings from a study exploring Australian academic librarians' concerns about the impact of misinformation and disinformation on society, university students and access to reliable information. It also investigates strategies librarians consider effective for addressing mis/disinformation through information literacy programs. Sixty-two librarians responded to a survey comprising Likert scale and open-ended questions. Respondents expressed the greatest concern about the influence of mis/disinformation on news media and social media. There was strong agreement that mis/disinformation should be regulated on social media and that librarians play a key role in addressing it through information literacy. However, views on the importance …

Additive Manufacturing And Heat Treatment Of Zero Poisson’S Ratio Self-Expanding Nitinol Stents, Farhana Yasmin, Vafadar, Majid Tolouei-Rad

Research outputs 2022 to 2026

Additive manufacturing (AM) has recently gained attention as an effective approach for printing patient-specific, self-expanding Nitinol (NiTi alloy) stents with complex structural designs for the treatment of peripheral arterial disease (PAD). However, achieving the desired phase transformation temperature and superelastic performance remains challenging due to compositional variations, phase imbalance and microstructural inhomogeneities introduced during the printing process. In this study, self-expanding Nitinol stents with a zero Poisson’s ratio (ZPR) structural design were fabricated via laser powder bed fusion (PBF-LB). The printed stents showed no evidence of cracks or structural defects, confirming PBF-LB’s capability to produce mechanically sound stent geometries. However, …

Becoming A Nurse: A Lifelong Journey Beyond The Transition To Professional Practice-An Analytical Discursive Paper, Seung A. Park, Eckert, Rebecca Sharp, Judy Duchscher, Micah D.J. Peters

Research outputs 2022 to 2026

Aim: To reconceptualise becoming a nurse as a lifelong developmental journey that extends beyond the traditional focus on new graduate transition, and to inform policies and practices supporting recruitment, retention and career sustainability. Background: The global nursing shortage persists, exacerbated by high attrition rates among new graduates and an aging workforce. While existing literature predominantly examines the transition from student to professional practice, we propose that ‘becoming a nurse’ begins earlier and extends beyond clinical roles into retirement. Design: An analytical discursive paper. Data Sources: Key theoretical frameworks (Schlossberg's Transition Model, Kennedy's Integrated Transition Model, Benner's Novice-to-Expert framework and Duchscher's …

Curriculum Approaches To Strengthening Student Employability And Improving Graduate Outcomes In The Stm Disciplines, Denise Jackson, Michael D. O’Connor

Research outputs 2022 to 2026

In Australia and elsewhere, curriculum improvements are needed to improve the development of Science, Technology and Mathematics (STM) graduates for future work and careers. Several studies document significant STM student attrition, poor graduate preparedness for work, relatively weak employment rates post-graduation, and mismatched expectations of graduate capabilities by employers. The inclusion of work-integrated learning (WIL) activities within curricula can better prepare students for relevant employment by bridging discipline-specific teaching with work practices. Traditionally, access to WIL has been limited for STM Bachelor students and a better understanding of WIL’s benefits and impact is needed to refine and extend STM WIL …

Women In The Australian Mining Industry, Michelle Gander, Fleur Sharafizad, Aglae Hernandez Grande, Heidi Vivian, Mahan Poorhosseinzadeh, Kate Blackwood

Research outputs 2022 to 2026

This report synthesises existing research on women’s participation in the Australian mining industry to identify the structural and cultural factors shaping gender inequality across the sector.

Drawing on research conducted over the past four decades, the report brings together what is currently known about how mining workplaces operate and how organisational practices, work arrangements, and site cultures shape the experiences of women across the sector. While many companies have introduced diversity and inclusion initiatives aimed at improving gender balance, the evidence suggests that challenges persist in areas such as operational roles, leadership pathways, and workplace culture.

Specifically, the report examines …

Feeling Giggity: Ambiguous Emojis In Teaching And Learning Communications, Mary Kynn, Nicole Reinke, Eva Hatje

Research outputs 2022 to 2026

There is an increase in the number of digital platforms used in higher education classrooms that promote using emojis to capture students’ emotions. However, there is little evidence to suggest that interpretation of emojis is reliable in this context. This pilot project explored if emojis can reliably signify the emotions expressed by first-year university students. Students were asked to record their emotions by selecting a representative emoji and using free text to describe its meaning. A total of 72 responses were recorded in an anonymous online survey. Happy face emojis were used more frequently than emojis representing neutral or unpleasant …

Numerically Evaluating The Effect Of Extrusion Angle On Material Flow And Thermal Behaviour During Additive Friction Extrusion Deposition (Afed), Numan Habib, Ferdinando Guzzomi, Ana Vafadar

Research outputs 2022 to 2026

Additive Friction Extrusion Deposition (AFED), also known as “SoftTouch”, is an emerging friction-based Additive Manufacturing (AM) technology allowing material to soften before the deposition, increasing the printing speed and reducing cost [1]. However, high power is required during the process, as excessive force is needed to extrude enough material through the printing head. This study investigates how extrusion angle and tool rotational speed affect thermal distribution and material flow in AFED to minimise power consumption. A three-dimensional computational fluid dynamics (CFD) model is proposed, and ANSYS ^® Workbench CFD code (Fluent) is used to discretise the CFD model. A User-Defined …

Sales Prediction In Omnichannel Distribution Systems Based On Consumer Behavior Using Process Mining And Arimax, Ferra Arik Tridalestari, Mustafid Mustafid, Ferry Jie, Hanung Nindito Prasetyo

Research outputs 2022 to 2026

Omnichannel distribution integrates multiple sales channels into a single management platform to enhance customer experience. However, the complexity of consumer behavior data across channels often prevents business owners from effectively analyzing and predicting sales. This study proposes a sales prediction model in omnichannel distribution systems based on consumer behavior using a collaborative approach that integrates process mining and autoregressive integrated moving average with exogenous variables (ARIMAX). Event log data from an omnichannel service provider were used to extract consumer activity patterns, which were then analyzed through process discovery algorithms to identify dominant behavioral processes. The resulting behavioral indicators served as …

Systematic Literature Mapping: Integrated System Of Logistic Distribution For Island, Eka Suswaini, Mochammad Agung Wibowo, Ferry Jie

Research outputs 2022 to 2026

Purpose: The study aims to identify and compare various methods used to optimize supply chain distribution, with a focus on uncovering novel approaches. It particularly addresses the gap in logistics distribution models tailored for island environments, proposing the development of an integrated information system using genetic and memetic algorithms to handle uncertainties like weather and vessel availability. Design/methodology/approach: A Systematic Literature Mapping (SLM) approach was adopted. The K-Chart method was applied to categorize conceptual strategies and identify research gaps. A case study was also included to analyze logistical challenges in island settings, incorporating real data variables like transportation schedules and …

The Effects Of Abused Drugs On Ferroptosis Pathways: Potential Therapeutic Targets For Substance Use Disorders, Tamara Bouchard, Brooke Russell, Liam Liyang Guo, Tina Nguyen, Yan Cheng, Yan Y. Sanders, Ming-Lei Guo

Department of Biomedical and Translational Sciences Faculty Publications

Substance use disorders (SUDs) remain major public health concerns worldwide, particularly in developed countries. SUDs are characterized by persistent neuroinflammation and synaptic dysfunction in the brain. Despite decades of extensive investigation, the detailed mechanisms underlying SUDs remain elusive. Ferroptosis is a highly regulated cell death process deeply affected by iron metabolism, lipid peroxidation, reactive oxygen species (ROS) production, and antioxidant systems. It has been implicated in multiple neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and ischemic stroke. Recently, emerging evidence has highlighted the role of ferroptosis in drug-induced pathological changes. Various types of abused …

Mapping Functional Connectivity In The Pigeon Brain With Wide-Field Optical Imaging, Kathryn C Chenard, Annie R Bice, Seana H Bice, Joseph P Culver, Paula Gerliz, Xavier Helluy, Onur Güntürkün, Jason W Trobaugh, Mehdi Behroozi, Carlos A Botero

2020-Current year OA Pubs

SIGNIFICANCE: Adapting optical imaging technology to avian models can overcome many limitations imposed by functional magnetic resonance imaging (fMRI), which currently restricts the number of species used to study functional connectivity. Developing advanced technology to expand the diversity of species that can be effectively imaged is crucial for addressing significant questions that are currently unreachable, such as understanding the evolution of cognition from a comparative perspective.

AIM: We assessed the potential of optical imaging technology to measure functional connectivity in birds, utilizing pigeons as an avian model. We evaluated whether we could partition the dorsal surface of the pigeon brain …

Investigating The Potential Utilisation Of Black Soldier Fly (Hermetia Illucens) As An Alternative Protein Source In Tilapia And Carp Feed, Sahya Maulu

School of Biological and Marine Sciences Theses

Three experimental trials were conducted to evaluate defatted black soldier fly (BSF; Hermetia illucens) larvae meal and BSF frass as alternative protein ingredients. Defatted BSF larvae meal was tested in diets for both Nile tilapia (Oreochromis niloticus) and mirror carp (Cyprinus carpio), whereas BSF frass was assessed only in Nile tilapia.In the first experiment, dietary inclusion of 20% and 40% BSF meal, replacing mainly soybean meal (SBM) and corn gluten meal (CGM), was evaluated in Nile tilapia over 5 weeks. BSF improved growth and feed utilisation in a dose-dependent manner, increased posterior intestinal fold length, muscularis thickness, and goblet cell …

Large-Scale Coastal Dynamics: New Incites From Lidar And Satellite Remote Sensing, Aikaterini Konstantinou

School of Biological and Marine Sciences Theses

This thesis leverages remote sensing methods to advance understanding of shoreline morphodynamics from storm to decadal timescales, focusing on three interrelated objectives. First, regional patterns and timescales of beach recovery following the extreme 2013/14 winter were quantified using bi-annual LiDAR and RTK-GNSS surveys of 23 south-west England sites. Recovery trajectories exhibited consistent patterns aligned with pre-existing storm response classifications, demonstrating that both storm response and post-storm recovery can be classified into four groups governed by intrinsic geomorphological and hydrodynamic controls. Almost 90% of sites had recovered at least 75% of lost sediment within three years, while some fully exposed beaches …

Impacts Of Microplastics In A Changing Agri-Environment, Riley Kent

School of Biological and Marine Sciences Theses

Microplastics are increasingly recognized as persistent contaminants in terrestrial ecosystems, yet their impacts on plant performance remain poorly understood under realistic environmental conditions. In natural and agricultural systems, plants rarely encounter contaminants in isolation, instead experiencing multiple interacting stressors. The work presented in this thesis investigated how soil microplastics influence plant growth and physiology both independently and in combination with freshwater flooding, a climate-relevant stressor associated with increased storm activity and shifts in precipitation patterns. Using white clover (Trifolium repens) as a model agronomic legume across multiple cultivars, the study examined how polymer identity, plant genotype, and environmental context interact …

Assessing Past Storm And Tsunami Events With Coastal Boulder Deposits: Implications For Offshore And Coastal Renewable Energy Infrastructure, Storm Roberts

School of Geography, Earth and Environmental Sciences Theses

Coastal boulder deposits are found on coastlines worldwide, transported inland by extreme storm or tsunami events. These deposits are understudied, yet hold unique information about the magnitude of the waves which emplaced them, enabling the addition of new events to the storm and tsunami record. However, boulder transport by storm waves is commonly misidentified as tsunami events, traditional methods for calculating boulder size are outdated, the influence of boulder shape on transport is understudied, there are difficulties making comparisons between physical experiments and field data, and commonly used equations for estimating wave flow velocities from boulders have been shown to …

Epithelial-Mesenchymal Transition And Stress Adaptations Underlie Yttrium-90 Resistance In Liver Cancer Cell Lines, Alexander Zheleznyak, Dhanusha Duraiyan, Prasanth Thunuguntla, Jessica Camacho, Shuang Wu, Jingxia Liu, Jason D Weber, Daniel L J Thorek, Benjamin S Strnad, Ryan C Fields, Matthew A Ciorba, Christine Yoon, Valerie Blanc, Nicholas Davidson, Jessica Silva-Fisher, Christopher D Malone

2020-Current year OA Pubs

UNLABELLED: Molecular signatures predict prognosis in hepatocellular carcinoma, but their relevance to transarterial radioembolization (TARE) with yttrium-90 (90Y) is unknown. We aimed to identify baseline and treatment-induced pathways associated with response and nominate biomarkers. Ten transcriptomically diverse human liver cancer cell lines were exposed to escalating activities of glass 90Y microspheres for 10 days. Normalized AUC values quantified sensitivity. Whole-transcriptome RNA sequencing at baseline and after treatment was analyzed with elastic net regression and gene set enrichment. Findings were corroborated by qRT-qPCR and exploratory analysis of pretreatment tumor samples from patients undergoing TARE. Liver cancer cell line responses to 90Y …

Oculomics And Ai: The Eye As A Biomarker For Health Span, Joy Le Yi Wong, Rajendra S Apte, Et Al.

2020-Current year OA Pubs

As the world's population ages, the focus of healthcare is shifting from extending life span to promoting health span. There is an unmet need to identify sensitive and reliable markers of health span through more cost-effective and non-invasive methods, to enable early and effective intervention on modifiable aging factors. The eye offers a unique window into systemic health, providing direct visualization of the body's vascular and neural health. This review presents an overview of how various ocular structures can serve as biomarkers of health span-drawing on insights from ocular imaging, metabolomics, and proteomics, with evidence from basic science, animal models, …

Novel Insights Into Early Alzheimer's Disease: Quantitative Gradient Recalled Echo Mri Reveals Preatrophic Neuronal And Myelin Injury Concurrent With Emerging Amyloid Pathology, Satya V V N Kothapalli, Tammie L S Benzinger, Randall J Bateman, Melody Li, Cihat Eldeniz, John C Morris, Dmitriy A Yablonskiy

2020-Current year OA Pubs

BACKGROUND: Brain amyloid accumulation is considered an early sign of Alzheimer's disease (AD) pathology, appearing decades before manifestation of clinical symptoms. However, very little is known about neurodegeneration during this early AD stage. Herein we use quantitative gradient recalled echo (qGRE) magnetic resonance imaging (MRI) to reveal preatrophic microstructural neuronal and myelin damage concurrent with amyloid pathology.

METHODS: qGRE MRI and positron emission tomography (PET) amyloid [

RESULTS: qGRE detected significantly lower gray matter neuronal density and white matter myelination in the group of participants with amyloid level below the conventional amyloid-positive threshold (mean cortical standardized uptake value ratio of …

Antihypertensive Medications And Risk Of Alzheimer's Disease: Evidence For Specific Medication Use, Osvaldo J. Laurido-Soto, Alejandra Camacho-Soto, Irene M. Faust, Kassu M. Beyene, Aaron Katz, Jordan A. Killion, Brad A. Racette

2020-Current year OA Pubs

No abstract provided.

Criterion Validity Of The Functional Status And Pain Assessment Scale Versus Pain And Length Of Stay In Hospitalized Adults With Scd, Wally R. Smith, Daniel M. Sop, Yue May Zhang, Margaret S. Guy, Rehan Qayyum

Department of Medicine Faculty Publications

Objectives

In prior research we demonstrated face, construct, discriminant, and preliminary convergent validity of the newly developed, 10-item Functional Status Pain Assessment (FSPA) scale (0-50) in adult SCD patients hospitalized with VOC. We aimed in this study to further demonstrate criterion validity of the FSPA.

Methods

This was a prospective observational study of 561 daily functional and pain assessments from 91 hospitalized adults with SCD from January 2018 to June of 2019. Principal Component Analysis (PCA) Partial Least Squares (PLS) models determined the relationship between LOS, pain intensity, and FSPA. A Generalized Linear Model (GLM) to quantified the impact of …

Circulating Biomarker Results From A Phase 2 Study Of Seralutinib In Pulmonary Arterial Hypertension, Robin Osterhout, Athénaïs Boucly, Raymond L. Benza, Richard N. Channick, Kelly M. Chin, Robert P. Frantz, Anna R. Hemnes, Luke S. Howard, Vallerie V. Mclaughlin, Olivier Sitbon, Jean-Luc Vachiéry, Rotham T. Zamanian, Richard Aranda, Matt Cravets, Zhaoqing Ding, Thao Duong-Verlé, David Mattola, Robert F. Roscigno, Ravikumar Sitapara, Lawrence S. Zisman, Jean-Marie Bruey, Hossein-Ardeschir Ghofrani

Department of Medicine Faculty Publications

[Introduction] To the Editor: Pulmonary arterial hypertension (PAH) is a progressive disease characterized by obstructive pulmonary arterial remodeling (1). Seralutinib, an investigational inhaled tyrosine kinase inhibitor, potently and selectively targets kinases relevant to PAH pathobiology including platelet-derived growth factor receptors (PDGFR) α and β, colony stimulating factor 1 receptor (CSF1R), and mast/stem cell growth factor receptor kit (c-KIT) (2). In preclinical models, seralutinib improved cardiopulmonary hemodynamics, reversed pulmonary vascular pathology and decreased right ventricular hypertrophy (3). In TORREY, a phase 2, multicenter, double-blind, randomized, placebo-controlled trial in PAH, seralutinib significantly reduced pulmonary vascular resistance (PVR) after 24 weeks with good …

Antibody-Drug Conjugates Beyond Her2 In Non-Small Cell Lung Cancer (Nsclc): Mechanisms, Emerging Targets, And Future Directions, Ahmed Ismail, Akash Desai, George R. Simon, Yanis Boumber

Department of Medicine Faculty Publications

Antibody–drug conjugates (ADCs) are a rapidly evolving class of oncology therapeutics that enable precise delivery of potent cytotoxic agents to tumor cells while minimizing systemic toxicity. While HER2-targeted ADCs such as trastuzumab deruxtecan (T-DXd) in HER2-mutant, Datopotamab deruxtecan (Dato-Dxd) in EGFR-mutant, and telisotumumab vedotin (Teliso-V) in MET IHC 3+ expressing lung cancer have already established a clinical role in non-small cell lung cancer (NSCLC), multiple ADCs targeting alternative antigens, including additional TROP2 ADCs, HER3, MET, CEACAM5, B7-H3, Nectin-4, and others, are now in advanced clinical development. This review synthesizes the current evidence for non-HER2 ADCs in NSCLC, highlighting mechanisms of …

Annual Report Of The Town Dalton, Nh, December 31, 2025, Dalton Town Representatives

Dalton, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Modulation Of Ccr2/Ccl2 Molecular Axis In The Expansion And Rupture Of Abdominal Aortic Aneurysms, Ryan Wahidi, Santiago Elizondo-Benedetto, Ryan Catlett, Bera Koklu, Mohamed A Zayed

2020-Current year OA Pubs

The CCR2/CCL2 molecular axis is a critical mediator of abdominal aortic aneurysm (AAA) pathogenesis. It has been demonstrated to drive chronic inflammation, extracellular matrix degradation, and vascular remodeling through the recruitment and activation of monocytes/macrophages and other immune cell types. Pre-clinical studies demonstrate that CCR2 inhibition reduces AAA formation, expansion, and progression in animal models. Emerging imaging techniques have validated CCR2 as a biomarker for AAA instability in humans. Although clinical trials targeting CCR2 are currently limited in number, ongoing translational studies highlight that CCR2 blockade is a promising therapeutic strategy to mitigate AAA expansion and the risk of rupture. …

Resolving Heterogeneity In Lymph Node Stromal Cells Using High-Dimensional Analysis Of Non-Optimized Flow Cytometry Data, Mikala E Heon, Eduardo Rosa-Molinar

2020-Current year OA Pubs

Lymph Node Stromal Cells (LNSCs) are a diverse population of cells responsible for maintaining the lymph node environment and regulating the immune response. Given these roles, they have the potential to help replicate lymph node functions