Digital Commons Network^™

Molecular Heterogeneity Of Hpv-Associated Cancers And Strategies To Overcome Treatment Resistance, Sara Rasouli, Weiyi Gong, Raegan Wood, Danyal Daneshdoust, Anam Khan, Rani Mahyoob, Chongwen Cao, Zihao Yu, Nagireddy Putluri, Gennady Shvets, Haichang Li, Bo Zhao, Xuefeng Liu, Jenny Li

Faculty, Staff and Students Publications

Human papillomavirus (HPV) is a major driver of global cancer incidence, responsible for nearly all cervical cancers and a significant proportion of oropharyngeal, anal, and other anogenital cancers. Despite the availability of effective vaccines, HPV-associated cancers persist due to persistent infection, immune evasion, and the virus's ability to integrate into the host genome, contributing to molecular heterogeneity and therapeutic resistance. Here, we summarize molecular heterogeneity and the emerging combined therapeutic strategies. High-risk HPV types, notably HPV16 and HPV18, initiate carcinogenesis through persistent infection of epithelial basal cells and through the actions of the E6 and E7 oncoproteins, which disrupt the …

Once-Weekly Navepegritide In Children With Achondroplasia: The Approach Randomized Clinical Trial, Ravi Savarirayan, Ciara Mcdonnell, Carlos A Bacino, Daniel G Hoernschemeyer, Janet M Legare, M Jennifer Abuzzahab, Paul L Hofman, Philippe M Campeau, Josep Maria De Bergua Domingo, Leanne M Ward, Kevin Smit, Alden Smith, Meng Mao, Michael S Ominsky, Lærke C Freiberg, Aimee D Shu, Hanne B Hove

Faculty, Staff and Students Publications

Importance: Historically considered a skeletal dysplasia characterized by disproportionate short stature, achondroplasia is a condition with multisystemic effects due to the widespread expression of the fibroblast growth factor receptor 3 variant throughout the body, impacting muscle, neurological function, cardiorespiratory health, and health-related quality of life.

Objective: To evaluate the efficacy, safety, and tolerability of once-weekly navepegritide, an investigational prodrug of C-type natriuretic peptide, while assessing benefits beyond growth that may have important implications for complications and health-related quality of life in children with achondroplasia.

Design, setting, and participants: Enrollment for this pivotal phase 2b, randomized, double-blind, placebo-controlled trial (APPROACH) was …

Case Report: Molecular Diagnostics And Clinical Courses Of Two Adult Spinal Pilocytic Astrocytoma Long-Term Survivors With Gtf2i::Braf Fusion, Lorenzo Argao, Pinar E Zerk, Hsiang-Chih Lu, Zied Abdullaev, Martha Quezado, Michelle L Cassidy, Bennett Mclver, Anna Choi, Marissa Panzer, Renee Tweneboah-Koduah, Lily Polskin, Marta Penas-Prado, Paul Park, Nathan Clarke, Kenneth Aldape, Jacob Mandel, Byram H Ozer

Faculty, Staff and Students Publications

Introduction: Pilocytic astrocytomas are driven by BRAF and mitogen-activated protein kinase (MAPK) alterations, typically KIAA1549::BRAF fusions. A rare GTF2I::BRAF fusion has been described, but little is known about these cases.

Case report: Here, we report two cases with GTF2I::BRAF fusions. Case 1 is a 36-year-old man initially diagnosed with myxopapillary ependymoma at the conus medullaris with three recurrences over 23 years requiring two surgeries, three rounds of radiation therapy, and one round of lapatinib/temozolomide. A distant disease focus in T3/T4 was sampled and tested with modern diagnostic techniques revealing a pilocytic astrocytoma on histology and methylation profiling. The patient has …

Astrocytic Sox9 Overexpression In Alzheimer’S Disease Mouse Models Promotes Aβ Plaque Phagocytosis And Preserves Cognitive Function, Dong-Joo Choi, Sanjana Murali, Wookbong Kwon, Junsung Woo, Eun-Ah Christine Song, Yeunjung Ko, Debosmita Sardar, Brittney Lozzi, Yi-Ting Cheng, Michael R Williamson, Teng-Wei Huang, Kaitlyn Sanchez, Joanna Jankowsky, Benjamin Deneen

Faculty, Staff and Students Publications

Astrocytes play essential roles in the brain, and their dysfunction is associated with nearly every form of neurological disease. Despite their ubiquity, knowledge of how astrocytes contribute to disease pathogenesis is incomplete; accordingly, harnessing their biology toward therapeutics remains a major challenge. Here we show that the transcription factor Sox9 plays a context-specific role in maintaining astrocyte function and circuit activity in the aging hippocampus and Alzheimer's disease (AD) models. We found that Sox9 overexpression in astrocytes in AD models clears existing amyloid beta (Aβ) plaques and preserves cognitive function. Mechanistically, Sox9 promotes the phagocytosis of Aβ plaques by astrocytes …

A. Vs. I In Ai: Is There A Threshold To "Engineered" Intelligence?, Joshit Mohanty

Engineering Management & Systems Engineering Faculty Publications

Despite artificial intelligence reshaping the world, its development generates uncertainties regarding future capabilities. AI simultaneously exists as an artifact of engineering design and as autonomous intelligence, creating an observer-participant feedback loop. This paper proposes that embodied AI faces a bandwidth-limited intelligence threshold T_h that it arises from B = min(C_sens,C_Act). However, Shannon capacity measures bits while intelligence operates on concepts, necessitating a dual-channel model separating physical bandwidth B_io from representational capacity B_rep. Intelligence emerges as multi-dimensional rather than scalar, with components exhibiting different bandwidth dependencies. Surpassing T_h requires either new sensing methods expanding B, enhanced representational frameworks, or reconceptualization within …

When Washington Won't Answer: The Case For State Civil Rights Enforcement Against Federal Officers, David Schultz

Mitchell Hamline Law Review

The traditional framework for vindicating federal constitutional rights through litigation has long rested on two pillars: the implied damages remedy recognized in Bivens v. Six Unknown Named Agents, available against federal officials, and the statutory cause of action codified at 42 U.S.C. § 1983, available against state and local officials. Both mechanisms are premised on a foundational constitu-tional principle: that governmental power exercised in violation of the Constitution must yield to judicial remedy. Yet recent developments have placed this principle under serious strain. The Supreme Court has systematically narrowed Bivens to near irrelevance, the federal courts have expanded the doctrine …

Recirculated Submarine Groundwater Discharge Dominates Nutrient Inputs And Enhances Eutrophication Risk In A Coastal Lagoon, Júlia Rodriguez-Puig, Clara Ruiz-González, Marc Diego-Feliu, Irene Alorda-Montiel, Aaron Alorda-Kleinglass, Daniel Romano-Gude, Andrea G. Bravo, Júlia Dordal-Soriano, Javier Gilabert, Sophia Bergeler, Celine Lavergne, Gemma Casas, Marisol Manzano, Jordi Garcia-Orellana, Valentí Rodellas

OES Faculty Publications

Submarine groundwater discharge (SGD) is a widely recognized pathway for nutrient transport to coastal systems. Prior studies overlook the unique biogeochemical signatures of different SGD pathways, neglecting their differences in biogeochemical transformations and spatiotemporal factors. Here, we present an integrated assessment of nutrient delivery through three SGD pathways (fresh SGD, long‐scale recirculated SGD, and short‐scale porewater exchange), alongside surface water inputs, to evaluate their seasonality and impact on nutrient dynamics in a coastal lagoon. We conducted five field surveys in March, July, and November 2021, July 2024, and March 2025 in the Mar Menor lagoon, an ecosystem facing severe ecological …

Microbial Mats In Dinosaur Ichnocoenoses, Nora Noffke, Paul C. Murphy, Roger C. Buntin, Martin G. Lockley

OES Faculty Publications

Until now, the significance of microbial mats in preservation of dinosaur tracks and in reconstructing the palaeoenvironment in which dinosaurs roamed was rarely studied. Dinosaur tracks are commonly found close to ancient aquatic bodies where moist sediment had once allowed footstep registration. At such sites, epibenthic or endobenthic microbial mats may have developed as well and may have led to exquisite track preservation. Microbial mats in coastal, lacustrine or flood plain environments cause 'microbially induced sedimentary structures—MISS', which are micobialites found in sandy or evaporitic settings. The microbial structures record environmental parameters including meteorological conditions that existed at the time …

Efficient Preservation Of Old Methane-Derived Organic Carbon In Deep-Sea Surface Sediments, Rui Bao, Yangli Che, Mingzhi Liu, Naiyu Zhang, Yang Zhou, Lihua Dong, Shen Li, Owen A. Sherwood, Min Yu, Zongheng Chen, Shengxiong Yang, Nan Wang, Longhai Zhu, Jiawang Chen, Mutai Bao, Haoshuai Li, Luonan Chen, Weifeng Wu, Haiyue Ma, David J. Burdige

OES Faculty Publications

Methane released from the subseafloor is significantly attenuated during upward migration, yet the preservation of methane-derived organic carbon (OC) in global deep-sea sediments remains poorly understood. Here, we measured carbon isotopes coupled with temperature-ramped analyses on various methane seepage sediments. Our results reveal a correlation between the radiocarbon (¹⁴)C) content in deep-sea surface sediments and sulfate-methane transition depth. Notably, our findings suggest that a substantial amount of (¹⁴)C-depleted OC may originate from deep-seated methane and is efficiently preserved in surface seepage sediments. We propose that the efficient OC preservation is related to microbial-mediated aggregate formation at the seawater-sediment interface, where …

Visualizing The Barely Detectable: Particle Characteristics Of The Elusive Aquatic Gel Phase In The Northeastern Subtropical Atlantic, Huanqing Huang, María Couret, Santiago Hernández-León, Alexander B. Bochdansky

OES Faculty Publications

Marine gels constitute a large yet poorly explored ocean carbon pool. Shadow imaging was tuned to detect particles at two sensitivity levels: high–optical density particles (HODP), resembling the particles captured by most imaging systems, and low–optical density particles (LODP), representing a vastly more abundant and gel-dominated pool. This method enabled us to map and characterize a portion of oceanic gels without filtration and staining. In the subtropical northeast Atlantic, LODP outnumbered HODP of the same size by one or two orders of magnitude. Morphology and particle number spectra differed greatly between the two pools, with LODP showing greater morphological homogeneity …

How To Build A Black Girl Traphouse:A Meditation And Manual For Black Feminist Survival In And Beyond The Academy, Loren Cahill, Brandyn-Dior Mckinley, Arianne Napier-White, Janae Peters, Jalisa Williams

School for Social Work: Faculty Publications

By design, the university is a colonizing, racializing, and classed space, built through unequal structures that perpetuate systemic violence (Peña, 2022). When many marginalized folks enter any university setting, they are marred by projections, judgments, assumptions, and assaults by those who question their worth, ability, and competence (y Muhs, Niemann, González, & Harris, 2012). Discriminatory actions and attitudes endured by Black women in academia often make us severely angry as well as mentally andphysically ill. Many of us are so traumatized that we choose to leave and/or are pushed out of our jobs. Those of us who choose to stay …

4th Circuit Panel Rejects Challenge To Defense Department Ban On Enlisting People Living With Hiv Infection, Arthur S. Leonard

Other Publications

No abstract provided.

4th Circuit Panel Affirms Denial Of Preliminary Injunction To Substitute Teacher Who Rejected School District’S Transgender Student Guidelines, Arthur S. Leonard

Other Publications

No abstract provided.

Civil Litigation Notes, Arthur S. Leonard

Other Publications

No abstract provided.

U.S. Supreme Court Rules A State Ban On Conversion Therapy For Minors Probably Violates The Free Speech Rights Of A Licensed Counselor Who Allegedly Performs Only “Talk Therapy”, Arthur S. Leonard

Other Publications

No abstract provided.

U.S. Supreme Court Approves “Outing” Of Transgender Students To Their Parents By Schools In Shadow Docket Ruling, Arthur S. Leonard

Other Publications

No abstract provided.

4th Circuit Rules That West Virginia’S Medicaid Coverage Exclusion Of “Sex-Change” Surgery Is Legal, Arthur S. Leonard

Other Publications

No abstract provided.

9th Circuit Panel Affirms Injunction Against Montana Anti-Drag Law, Arthur S. Leonard

Other Publications

No abstract provided.

Film In Illiberal Times: Poland’S Public Memory And The European Union, Frances Tanzer

History

This article is about the recent transformation of two powerful, paradoxical, and inseparable narratives of progress that developed in the postwar period: aesthetic autonomy and Holocaust remembrance. As far-right and illiberal parties have gained power across Europe, they adapted these foundational narratives of the liberal-democratic West to assert their own legitimacy and to reimagine the cultural inclinations of the European Union. This article examines how this process has taken place in the reception of Jonathan Glazer's Zone of Interest (2023) and Agnieszka Holland's Green Border (2023)—both international co-productions produced during the repressive eight-year reign of the Law and Justice Party …

Evaluating Artificial Intelligence Large Language Mocdels In Dental Education: A Cross-Sectional Survey On Usage, Perceptions, And Integration At A U.S. Dental Scho

Faculty, Staff and Student Publications

Introduction: The adoption of artificial intelligence (AI) in higher education presents opportunities and challenges for dental education. This study explores the use of Large Language Model (LLM) based AI tools, including ChatGPT and Grammarly AI, among faculty and students at the UTHealth School of Dentistry in Houston (UTSDH). This research assessed usage patterns, perceived benefits and concerns, and AI training demand.

Methods: A piloted, cross-sectional survey was administered via email. The survey included Likert-scale, multiple-choice, and open-ended questions. Respondents provided demographics and rated their LLM-based AI tools for use and perceptions in educational, clinical, and research contexts. Data was analyzed …

Reproductive Rights On Campus, Janet Levit

Articles, Chapters in Books and Other Contributions to Scholarly Works

No abstract provided.

Courts Of Indian Offenses, Courts Of Indian Resistance, Alexandra Fay

Articles, Chapters in Books and Other Contributions to Scholarly Works

No abstract provided.

A Multiscale Computational Framework Bridging Molecular Dyanmics, Phase-Field, And Elasto–Viscoplstic Fast Fourier Transform: Applications To Process–Structure–Property Relationships In Metallic Materials, Chaimae Jouhari

Electronic Theses and Dissertations

Metallic materials exhibit process–structure–property relationships that arise from physical mechanisms operating across multiple length and time scales. Atomistic processes control diffusion, thermal response, and interfacial behavior; mesoscale mechanisms govern grain morphology, interface migration, and microstructure evolution; full-field crystal-plasticity calculations resolve heterogeneous mechanical fields; and continuum-scale finite-element (FE) models connect material response to component-level deformation, damage, and performance. Because no single simulation method can resolve all of these mechanisms, predictive modeling requires a framework in which information obtained at one scale can be transferred to the next. This dissertation develops a multiscale computational framework that bridges molecular dynamics (MD), phase-field (PF) …

Securing Smart Agriculture With Communication-Efficient Federated Unlearning, Ujjwal Pudasaini

Electronic Theses and Dissertations

This thesis addresses the data poisoning attack in smart agricultural systems using federated unlearning, where the contribution of compromised field devices must be removed from the global model under communication constraints. We propose FedSCAN, a three-phase framework that identifies critical layers based on parameter sensitivity, classifies active neurons within these layers through relative weight change analysis, and performs unlearning via sparse low-rank adaptation to active neurons while freezing base model parameters. FedSCAN limits computational overhead to a compact parameter subset, enabling devices to participate in a communication-efficient manner. Experimental results on four datasets demonstrate that FedSCAN achieves up to 426.3× …

Production Of Fungal Biomass And Crude Chitin From Cheese Whey: Effects Of Whey Type And Lactose Hydrolysis On Aspergillus Niger And Trichoderma Reesei, Anye Catharine Nora Drum

Electronic Theses and Dissertations

Chitin is a biodegradable and biocompatible biopolymer with broad applications in the food, biomedical, pharmaceutical, and packaging industries. Conventional chitin production from crustacean shells is associated with seasonal availability, intensive chemical processing, and environmental concerns, creating interest in more sustainable alternatives. Filamentous fungi represent a promising source of chitin because of their rapid growth and ability to utilize low cost agro-industrial residues. This study evaluated the feasibility of producing fungal biomass and crude chitin from cheese whey through submerged fermentation while investigating the effects of whey type and enzymatic lactose hydrolysis on fungal growth, substrate utilization, and wastewater remediation. Aspergillus …

Primary Avian Tracheal Cell Models For The Isolation Of Emerging Avian Metapneumovirus Strains, Tricia Serrao

Electronic Theses and Dissertations

The emergence of avian metapneumovirus (aMPV) subgroups A and B in the United States poultry industry has created an urgent need for standardized, host-specific diagnostic platforms. Historically, reliance on continuous, multi-species cell lines has limited the primary isolation of field strains and introduced potential adaptation artifacts. To address these challenges, this research first established and characterized a reproducible primary cell culture system derived from the tracheal tissues of 1-day-old turkey poults. This system was maintained in an optimized DMEM/F-12 formulation supplemented with 5% FBS, EGF, and ITS, with early-passage cultures achieving 90% confluence within 24 to 48 hours. Morphological and …

Enzyme Susceptibility And Functionality Of High Protein Retentates And Reconstituted Ingredients, Khushi Dubey

Electronic Theses and Dissertations

This thesis explores the effects of processing history on the enzymatic susceptibility and functional properties of high-protein dairy ingredients, with a specific focus on ultrafiltered (UF) and microfiltered (MF) retentates and spray-dried powders. While retentates and powders are often used interchangeably in industrial applications, processing steps, such as drying, can induce structural and physicochemical changes that affect protein functionality and enzyme accessibility. Milk protein concentrates (MPC) and micellar casein concentrates (MCC) were standardized to 10% protein and subjected to enzymatic treatments, including proteolysis (Alcalase and rennet) and crosslinking (transglutaminase and laccase). Structural modifications were evaluated using capillary gel electrophoresis, non-protein …

Detecting And Characterizing Latent Subpopulations Of Classes Via Mixture Models, Andrew Simpson

Electronic Theses and Dissertations

A class of problems in statistical pattern recognition exists in which there is high-dimensional data with few realizations per class, commonly referred to as few-shot learning. Data that arises in forensic source identification, which deals with providing a probabilistic value of evidence with regard to the source of some object, falls into this class of problems. Namely, the data is sampled from a hierarchical sampling process, lives in a high-dimensional space, the number of sources (or classes) tends towards infinity, and there are few observations per source. This can be thought of as a few-shot learning problem. Because of these …