Digital Commons Network^™

The Judicial Containment Of Adivasi Rights Across India's Mineral Belt, Sajni S. Sheth-Voss

Scripps Senior Theses

This thesis examines how Adivasi resistance to mining-induced dispossession across India’s mineral belt is increasingly channeled into the judiciary, arguing that this shift functions as a mechanism of containment rather than a pathway to justice. Despite a robust legal framework designed to protect Adivasi land and consent rights, systematic non-enforcement and political closure have hollowed out policy and electoral channels, pushing communities into litigation as a last resort. Drawing on scholarship in political economy, legal studies, and political ecology, alongside primary sources including court documents and activist statements, this study follows how disputes move across institutions and are ultimately reshaped …

How Semiflightless Birds Adapt: A Survey From Barú, Costa Rica, Eli P. Laloudakis

Scripps Senior Theses

When we think of birds, we think of flight. Because of this, scientific research often focuses on how birds evolved flight and how their wings function during flight. However, not all birds can fly or fly well, as wings wax and wane on developmental, seasonal, and evolutionary time scales (Dial and Heers 2021). Consequently, rudimentary wings can be found in developing birds, secondarily flightless or semiflightless birds, birds that undergo simultaneous molts, and extinct theropods with “protowings” (structures that preceded fully functional wings). Secondarily flightless and semiflightless birds often evolve where there is no/low predation, abundant year-round food supply, and …

L'Affaire Baby Loup : Nouvelle Laïcité Ou Laïcité Coloniale ?, Grace Gorden

Scripps Senior Theses

La saga juridique de la crèche Baby Loup, où une directrice-adjointe était licenciée pour avoir porté le voile au travail, est souvent proclamée comme l'instauration de la « nouvelle laïcité » en France.  L'arrêt Baby Loup fait partie d'une série de changements sur la laïcité depuis les années 1980 en France, où le principe de laïcité devient de plus en plus associé au domaine privé. Le jugement final de la saga Baby Loup établit que la discrimination religieuse doit être jugée selon des normes de proportionnalité et de justification. Ce renoncement au principe de laïcité dans les tribunaux et ensuite …

Just War Theory In The Hunger Games: Suzanne Collins’S Critique Of Violence, Power, And Rebellion, Laila Hannum

Scripps Senior Theses

This thesis applies just war theory to Suzanne Collins's The Hunger Games trilogy, arguing that while the districts' rebellion satisfies the principles of jus ad bellum (justice in going to war), it systematically violates jus in bello (justice in the conduct of war) and jus post bellum (justice after war), and ultimately replicates the oppressive structures of the Capitol it sought to overthrow.

Drawing primarily on Michael Walzer's Just and Unjust Wars and on Brian Orend's ideas on post-war justice, this thesis traces the rebellion's moral arc across all three novels. Chapter One shows that the rebellion meets the criteria …

Prevalence Of Substance Use In Northwest Syria: A Cross-Sectional Study, Isabel Draper, Dania Albaba, Heba Mesbah, Huda Taktak, Nidhal Saadoun, Mohammad Alhusein, Elharit Alissa, Anas Barbour, Zaher Sahloul, Nidal Moukaddam

Faculty, Staff and Students Publications

Objectives: Syria has undergone significant socio-political turmoil since 2011 as internal conflict displaced portions of the population, destroyed infrastructure, and destabilized the economy. In the context of multilevel healthcare system disruptions, there have been increasing reports of substance use. This study seeks to evaluate patterns of substance use in Northwestern Syria.

Methods: Trained staff administered questionnaires to community members in Azaz, Syria. Questions focused on the substance use prevalence, societal and public health impacts, and perspectives on treatment availability.

Results: 480 individuals were surveyed (80·88% male, 19·12 % female; 43·39% were 18-25 yrs, 11·5% reported personal substance use). H-booz (amphetamines), …

Variability In Documentation Of Neurological And Psychiatric Examinations Among Emergency Department Patients With Behavioral Health-Related Presentations: A Retrospective Study, Heba Mesbah, Payton Kim, Jide Oluwadare, Abdulelah Almanie, Inaara Malick, Nidal Moukaddam

Faculty, Staff and Students Publications

Background: Emergency departments (EDs) serve as a critical safety net for individuals experiencing acute behavioral health crises, a population that faces substantial medical morbidity and well-documented disparities in healthcare delivery. Thorough physical and neuropsychiatric assessment is essential in this setting to identify medical conditions that may mimic or exacerbate psychiatric symptoms. Incomplete documentation of these assessments may reflect gaps in care processes and represent a potential marker of inequity.

Objective: To characterize the completeness of documented neurological and psychiatric examinations among adult ED patients presenting with primary behavioral health-related chief complaints and to assess whether documentation patterns suggest persistent gaps …

Challenges In The Diagnosis Of Concurrent T-Lymphoblastic Leukemia/Lymphoma And Thymic Neuroendocrine Carcinoma: A Case Report, Kristen Oliveira, Mary Doan, Ying Pei, Marwan Yared, Songlin Zhang

Faculty, Staff and Students Publications

The co-occurrence of T-lymphoblastic leukemia/lymphoma and thymic neoplasia is a rare event that can present a diagnostic challenge. In this case report, we describe a 31-year-old man who was found to have thymic neuroendocrine carcinoma and T-lymphoblastic leukemia/lymphoma 2 years after initial treatment for T-lymphoblastic leukemia/lymphoma. The thymic neuroendocrine carcinoma was initially detected in a malignant pleural effusion, and a retrospective review of a preceding lung biopsy suggested the involvement of both tumors within one tissue sample. Immunohistochemical analysis was imperative in highlighting these two elements because despite their unique cytomorphological characteristics, a limited amount of each component was seen …

Real Interpolation: An Approximate Introduction, Madeline Anderson

Scripps Senior Theses

This thesis provides an introduction to real interpolation. We establish

relevant notions in functional analysis first, and use these concepts to study

real interpolation using J. Peetre’s 𝐾-functional in some detail. We also

explore the basics of approximation theory, in particular the connection

between approximation and interpolation results.

Making Faces, Elinor Attisani

Scripps Senior Theses

Making Faces is a series of gelatin silver prints and moving images that argues that identity is constructed through– rather than simply reflected in– repeated choices and behaviors. Through my project, I suggest that gender is not innate, but rather, performed. The images visualize the process through which a gendered self is established. A series of representations of Mari in costume come together to demonstrate the practicing of gender, and point to the illusory nature of the notion of a pre-existing, essential self. This representation of an exaggeratedly feminine subject is highly staged and theatrical, compelling the viewer to look …

Evaluating Acupuncture As An Adjunct To Standard Ulcerative Colitis Therapy, Mia A. Ciotti

Scripps Senior Theses

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by recurring cycles of flare and remission that significantly affect patients’ quality of life. Standard allopathic treatment for UC centers on mesalamine, a 5-aminosalicylic acid drug that acts locally on the colon to reduce inflammation, but does not cure the disease entirely. Acupuncture, rooted in Traditional Chinese Medicine, has been proposed as an adjunct therapy for inflammatory conditions, yet its biomedical efficacy remains uncertain due to methodological limitations and insufficient controls of prior studies.

This study proposes a randomized, participant and assessor blinded clinical trial evaluating mesalamine, true acupuncture, sham …

Broadening The Fetal Alcohol Paradigm: Bdnf Methylation As A Link Between Paternal Alcohol Use And Offspring Neurodevelopmental Deficits, Caitlin E. Muñoz

Scripps Senior Theses

Developmental effects of fetal alcohol exposure are extensively documented as a consequence of maternal gestational alcohol consumption. However, similar consequences of paternal alcohol consumption remain understudied. This proposed pilot study will examine preconception paternal alcohol consumption within its capacity to induce heritable epigenetic modifications in sperm, such that offspring are susceptible to adverse in utero neurodevelopment and neonatal neurobehavioral outcomes. Specifically, it will examine DNA methylation patterns along the brain-derived neurotrophic factor (BDNF) exon IV promoter in paternal spermatozoa. BDNF exon IV is considered a key locus in neurogenesis regulation, synaptic plasticity, and cortical development. It is hypothesized that BDNF …

Madison, Wisconsin As A Climate Haven: Infrastructure, Environmental Justice, And Community Voice, Sophia N. Heffner

Scripps Senior Theses

As climate change accelerates internal migration within the United States, the concept of “climate havens” has emerged as a way to identify communities that may become receiving zones for displaced populations. Madison, Wisconsin has increasingly been positioned within academic, policy, and media discourse as a potential climate haven due to its geographic advantages, strong public infrastructure, and proactive climate policy environment. This paper evaluates Madison’s readiness for this role through an equity-centered, participatory planning lens. Drawing on planning documents, climate data, municipal policies, and interdisciplinary scholarship, it argues that Madison’s long-term success as a sustainable and inclusive climate haven depends …

Cycling For All: Designing With The "Invisible Cyclist" As A Pathway Towards Urban Sustainability And Citizenship, Eloise Heimert

Scripps Senior Theses

This thesis explores the role of “invisible cyclists” in cycling networks and practices. Through an application of the “right to the city,” spatial production, and mobility justice frameworks, this paper investigates the experiences of women and disabled cyclists in London, England. By examining a city with an emerging cycling network, this thesis offers insight into measures for increasing the inclusivity and resilience of them. The argument establishes that these lines of analysis reveal important lessons in urban design and planning for a more sustainable future. Firstly, this thesis examines social barriers to cycling participation, and thus urban citizenship. In the …

Astrocytic Sox9 Overexpression In Alzheimer’S Disease Mouse Models Promotes Aβ Plaque Phagocytosis And Preserves Cognitive Function, Dong-Joo Choi, Sanjana Murali, Wookbong Kwon, Junsung Woo, Eun-Ah Christine Song, Yeunjung Ko, Debosmita Sardar, Brittney Lozzi, Yi-Ting Cheng, Michael R Williamson, Teng-Wei Huang, Kaitlyn Sanchez, Joanna Jankowsky, Benjamin Deneen

Faculty, Staff and Students Publications

Astrocytes play essential roles in the brain, and their dysfunction is associated with nearly every form of neurological disease. Despite their ubiquity, knowledge of how astrocytes contribute to disease pathogenesis is incomplete; accordingly, harnessing their biology toward therapeutics remains a major challenge. Here we show that the transcription factor Sox9 plays a context-specific role in maintaining astrocyte function and circuit activity in the aging hippocampus and Alzheimer's disease (AD) models. We found that Sox9 overexpression in astrocytes in AD models clears existing amyloid beta (Aβ) plaques and preserves cognitive function. Mechanistically, Sox9 promotes the phagocytosis of Aβ plaques by astrocytes …

Associations Of Blood Pressure Level And Variability With Cortical Thickness: A Cross-Sectional Analysis From The Maracaibo Aging Study, Romeo De Leon, Shana Garza, Silvia Mejia-Arango, Kristina Vatcheva, Sokratis Charisis, Claudia L. Satizabal, Luis J. Mena, Joseph H. Lee, Joseph D. Terwilliger, Eron Manusov

School of Medicine Publications

Background: Although high blood pressure (BP) level and variability are associated with Alzheimer's Disease (AD), their relationship with cortical thickness in brain regions that are associated with AD is unclear. Furthermore, the role of 24-hour BP has not been examined. We investigated the associations of office and ambulatory BP measures with cortical thickness in brain regions implicated in AD.

Methods: We performed a cross sectional analysis of 304 participants without dementia from a population-based study with office and 24-hour BP and magnetic resonance imaging (MRI) data. We considered cortical thickness values derived from 10 regions throughout the frontal, parietal, and …

Nh 4-H Horse Quiz Bowl Packet, Unh Cooperative Extension

UNH Cooperative Extension

No abstract provided.

Challenging Agency Deregulation, Todd S. Aagaard

Faculty Publications

The administrative state is experiencing two seismic shifts. First, in recent years, the Supreme Court has issued a series of decisions that significantly curtailed the powers of administrative agencies. Second, President Donald Trump is using administrative agencies to aggressively deregulate in his second term. The conventional wisdom is that the Supreme Court’s recent precedent will facilitate the Trump Administration’s deregulatory agenda.

This Article argues the opposite. Instead of promoting agency deregulation, recent Supreme Court precedent restraining agency authority provides a potentially powerful basis for challenging agency deregulation as administrative overreach. Time and time again, the Court has taken agencies to …

Your Wellness Wheel [Activity], Alyssa Lemmermann, Kendra Lewis

UNH Cooperative Extension

No abstract provided.

The Rna-Binding Protein Hur Modulates The Expression Of The Disease-Linked Ccl2 Rs1024611g-Rs13900t Haplotype, Feroz Akhtar, Joselin Hernandez-Ruiz, Ya-Guang Liu, Roy G. Resendez, Denis Feliers, Liza D. Morales, Alvaro Diaz-Badillo, Donna M. Lehman, Rector Arya, Juan Carlos Lopez-Alvarenga, John Blangero, Ravi Duggirala, Srinivas Mummidi

School of Medicine Publications

CC-chemokine ligand 2 (CCL2) is involved in the pathogenesis of several diseases associated with monocyte/macrophage recruitment, such as HIV-associated neurocognitive disorder (HAND), tuberculosis, and atherosclerosis. The rs1024611 (alleles: A>G; G is the risk allele) polymorphism in the CCL2 cis-regulatory region is associated with increased CCL2 expression in vitro and ex vivo, leukocyte mobilization in vivo, and deleterious disease outcomes. However, the molecular basis for the rs1024611-associated differential CCL2 expression remains poorly characterized. It is conceivable that genetic variant(s) in linkage disequilibrium (LD) with rs1024611 could mediate such effects. Previously, we used rs13900 (alleles: C>T) in the CCL2 …

Pd-L1-Centric Whole Blood-Based Immune Signature Profiles Of Tuberculosis Patients During Therapy, Johanna Eggeling, Martina Sester, Christoph Lange, Jan Heyckendorf, Barbara Kalsdorf, Anna M Mandalakas, Andrew R Dinardo, David Lewinsohn, Dagmar Schaub, Tina Schmidt, Eva Tolosa, Maja Reimann, Patricia M Sánchez Carballo

Faculty, Staff and Students Publications

This prospective study investigated whole blood-based immune cell biomarkers for pulmonary tuberculosis (TB) immunoprofiling. Blood samples from 34 healthy controls and 51 tuberculosis patients were analyzed at three timepoints: Prior to therapy (T0), after 14 days of therapy (T1), and at the end of treatment (Te). Using multiparameter flow cytometry, 386 immune cell populations were analyzed. Predictive models were developed using two machine learning algorithms. A TB5LF change score, which was based on five cell populations, effectively distinguished tuberculosis patients from controls (AUC = 0.89) and tuberculosis patients before and at the end of treatment (AUC = 0.92). Similarly, the …

The Effects Of The Opioid Crisis On Contraceptive Decisions And Fertility In Pakistan, Simren R. Khan

Scripps Senior Theses

This paper examines how the opioid epidemic influences household fertility behavior in Pakistan by analyzing contraceptive use and fertility outcomes across regions with differing levels of opioid prevalence. Using household-level data from the 2017–18 Pakistan Demographic and Health Survey (DHS) and estimating OLS regression models, the study compares households in high-prevalence regions with those in low-prevalence regions. The results show that exposure to high-opioid regions is associated with lower fertility outcomes and a higher likelihood of respondents wanting their last child. These patterns suggest that households may respond to opioid-related economic and caregiving burdens by limiting family size and treating …

Case Report: Molecular Diagnostics And Clinical Courses Of Two Adult Spinal Pilocytic Astrocytoma Long-Term Survivors With Gtf2i::Braf Fusion, Lorenzo Argao, Pinar E Zerk, Hsiang-Chih Lu, Zied Abdullaev, Martha Quezado, Michelle L Cassidy, Bennett Mclver, Anna Choi, Marissa Panzer, Renee Tweneboah-Koduah, Lily Polskin, Marta Penas-Prado, Paul Park, Nathan Clarke, Kenneth Aldape, Jacob Mandel, Byram H Ozer

Faculty, Staff and Students Publications

Introduction: Pilocytic astrocytomas are driven by BRAF and mitogen-activated protein kinase (MAPK) alterations, typically KIAA1549::BRAF fusions. A rare GTF2I::BRAF fusion has been described, but little is known about these cases.

Case report: Here, we report two cases with GTF2I::BRAF fusions. Case 1 is a 36-year-old man initially diagnosed with myxopapillary ependymoma at the conus medullaris with three recurrences over 23 years requiring two surgeries, three rounds of radiation therapy, and one round of lapatinib/temozolomide. A distant disease focus in T3/T4 was sampled and tested with modern diagnostic techniques revealing a pilocytic astrocytoma on histology and methylation profiling. The patient has …

Dual Targeting Of Amrc12 And Malassezia Globosa Disrupts Myc Liquid Condensates-Driven Nuclear Pore Complex Biogenesis In Neuroblastoma, Anpei Hu, Chunhui Yang, Zhijie Wang, Xiaolin Wang, Xinyue Li, Shunchen Zhou, Bosen Zhao, Jiaying Qu, Xiaojing Wang, Liduan Zheng, Qiangsong Tong

Faculty, Staff and Students Publications

Rationale: Neuroblastoma (NB) is a predominant extra-cranial malignancy in childhood, while molecular drivers of its progression and effective treatment strategies have yet to be clarified.

Methods: RNA sequencing was performed to identify transcriptional regulators and corresponding target genes. To explore the biological effects and underlying mechanisms of these regulators, a comprehensive methodology was utilized, encompassing chromatin immunoprecipitation, dual-luciferase reporter assay, qRT-PCR, western blot, alongside gene over-expression and silencing techniques, co-immunoprecipitation, and mass spectrometry. The MTT assay, soft agar colony formation, Matrigel invasion, and nude mouse xenograft models were applied to assess oncogenic properties. Patient survival was analyzed using the log-rank …

The Role Of Δ-Containing Gabaa Receptors In Modulating Experimental Kainic Acid-Induced Seizures In Adult Mice, Julia Gudis

FCRH Honors Program Theses

Epilepsy, a neurological disorder characterized by recurrent seizures, is often driven by hyperexcitable neural circuits that result from an imbalance between excitatory and inhibitory signaling. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system and is essential for maintaining neuronal excitability. One mechanism through which GABA exerts inhibitory control is via δ-subunit–containing γ-aminobutyric acid type A receptors (δ-GABAARs), which mediate tonic inhibition by providing steady background suppression of neuronal activity. δ-GABAARs are particularly enriched in the DG, where they help regulate the excitability of granule neurons and preserve the DG’s gating function. This project will test …

Emotional Expression For Community Healing: A Study Of Restorative Justice Circle Discussions Addressing Social Harm, Hannah Darnell

FCRH Honors Program Theses

Restorative justice (RJ) programs have increasingly been used to respond to social harm, and at times have been employed as alternatives to some of the United States’ traditional criminal court procedures. Studies suggest that these restorative programs find success in repairing relationships and reintegrating individuals back into their communities, tend to be perceived as positive by participants, and have the potential to reduce recidivism rates. This study explores how and why these restorative justice meetings work through an examination of the presence and evolution of participant emotional expression, as well as the role that outward communication of emotion has in …

The Manifestation Of Antihaitianismo In Abinader’S Dominican Political Atmosphere, Isabella Alcantara

FCRH Honors Program Theses

In the past decade, Haitian migration has become central to Dominican political discourse. This shift is particularly evident under President Luis Abinader’s administration, which has overseen a sharp increase in restrictive border enforcement and citizenship measures targeting Haitian migrants fleeing escalating humanitarian crises. While existing scholarship on Dominican nationalism highlights the historical role of antihaitianismo in shaping exclusionary state practices, less attention has been paid to how contemporary elite rhetoric reproduces these dynamics in more indirect, coded ways. Drawing on theories of symbolic politics and securitization, this study examines how state discourse constructs Haitian migrants within national narratives. It asks: …

Anything But Endo: Diagnostic Buck-Passing In Endometriosis Diagnosis, Rita Dexter, Megan Kitts, Heather Welty, Melanie Jeske

Center for Medical Ethics and Health Policy Staff Publications

People living with endometriosis, a disease in which tissue similar to the lining of the uterus grows elsewhere in the body, often experience prolonged diagnostic journeys because of symptom variability, normalisation of period pain and other symptoms, and lack of awareness of the condition. In this article, we analyse the endometriosis diagnostic journey through the lens of epistemic injustice. Drawing on in-depth interviews with 52 people living with endometriosis in the United States, we introduce the concept of diagnostic buck-passing to characterise the phenomenon wherein individuals who seek treatment for their symptoms end up stuck in a cycle of seeing …

Toward Ethical Provenance Tracking: The Ga4gh Model Data Access Agreement (Daa), Alexander Bernier, Bartha Maria Knoppers, Jonathan Lawson, Robyn Mcdougall, Maili Raven-Adams, Vasiliki Rahimzadeh

Center for Medical Ethics and Health Policy Staff Publications

Purpose: Standardizing contractual clauses that govern data access enables research institutions to responsibly steward genomic and related health data while enabling its efficient downstream reuse.

Methods: We describe a document analysis study using both qualitative and comparative law analytical approaches to identify the most common categories of clauses from 29 different data access agreements used by human biomedical research consortia globally. We furthermore characterized the legal positions and standard practices for each common element of the agreement and synthesized across them to develop model clauses. A total of 3 discussion sessions were organized virtually to refine the clauses among members …