Digital Commons Network^™

Expanding Natural Product Diversity Through Biotransformation, Emerson Queiroz

Oxford ICSB

Over the past decade, natural product research has undergone a methodological revolution [1]. Modern approaches now integrate advanced metabolite profiling techniques for compound annotation and prioritization, together with high-resolution chromatographic methods that enable seamless transition from analytical to preparative scales [2]. These tools have facilitated the detection and identification of minor bioactive constituents. Nevertheless, plant extracts typically contain abundant common scaffolds with limited relevance for drug discovery. In this context, enzymatic biotransformation emerges as a promising strategy to enhance chemical diversity and unlock new structural space. Two complementary biotechnological approaches have been developed: enzymatic transformation using fungal secretomes (crude extracellular …

2026 Urs Abstract Booket, Undergraduate Research Center, Minnesota State University, Mankato

Undergraduate Research Symposium

Complete Schedule of Events for the 28th Annual Undergraduate Research Symposium at Minnesota State University, Mankato.

Establishment Of A Hek293t Cell Model System To Investigate Direct Intracellular Interactions Between Amyloid-Β (Aβ) And The Nlrp3 Inflammasome, Cristina Sinobas Pereira

Dissertations

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia worldwide. While Amyloid-β (Aβ) aggregation is a defining pathological feature, increasing evidence highlights chronic neuroinflammation as a critical contributor to disease progression. Soluble Aβ assemblies can act as damage associated molecular patterns (DAMPs) including activation of the NLRP3 inflammasome, which links amyloid pathology to sustained inflammatory responses in the brain (Heneka et al., 2015; Nakanishi et al., 2018). However, the molecular mechanisms by which specific Aβ conformations influence inflammasome assembly remain incompletely understood.This study aimed to investigate whether distinct aggregation states of amyloid β42 (Aβ42) are …

April 23, 2026, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Beyond The Numbers: Supporting Young Adults With Diabetes In The Transition To Adulthood, Alexis Salkovick

Honors Projects

This project focuses on the transition to adulthood for young people with diabetes, a chronic medical condition. Both Type 1 and Type 2 diabetes are included. The main research focus is two-part: first examining this transition including barriers to health care, changes in lifestyle, and mental health, and then creating a new, innovative tool to support young adults with diabetes. An independent literature review was conducted to investigate diabetes management, barriers to health care, how transitioning to adulthood impacts diabetes care, and the importance of patient support systems. Then, a board game was developed with the dual purpose of educating …

“As Though You Could Never Sink”: Gender Euphoria Through Aquatic Embodiment In The Sun Also Rises, Devan Edwards

Honors Theses

Recent scholarship in disability studies and queer theory (2007-2024) reveals that Jake Barnes's war wound in Hemingway's The Sun Also Rises functions as something more complex than tragic loss. This paper argues that Jake's swimming and fishing scenes constitute moments of gender euphoria, a term borrowed from contemporary transgender studies, enabled specifically by aquatic embodiment. In these scenes, water functions as the physical and symbolic medium through which Jake's war-wounded body transcends the performative demands of 1920s heteronormative masculinity. Building on Michael Anesko's provocative reading of Jake as "accidentally transgendered" (Literature and Medicine, 2015) and Martina Kübler's argument that impotence …

The Boys From Syracuse, Richard Rodgers, Lorenz Hart, George Abbott

Taylor Theatre Playbills

The playbill for Taylor University's performance of The Boys from Syracuse with music by Richard Rodgers, lyrics by Lorenz Hart, and the book by George Abbott.

Performed April 23-26, 2026 in the Mitchell Theatre at Taylor University.

The Boys from Syracuse by Rodgers and Hart is based on the play The Comedy of Errors by William Shakespeare, likely written in the late 16th century. As is common for many Shakespearean plays, he adapted an older story, Plautus' Menaechmi, into his classic farce about two sets of twins, separated by a tragic sea accident, who find each other after many …

Spectator 2026-04-23, Editors Of The Spectator

The Spectator

No abstract provided.

April 23, 2026, Caa

Minutes

No abstract provided.

Modulating Acute Stress Reactivity: Behavioral Interventions And Caffeine-Linked Stress Physiology In College Students, Kaitlyn Smith

Honors Theses

College students frequently rely on caffeine to manage academic demands, yet its physiological and psychological effects on acute stress remain poorly understood. Although caffeine is known to increase cardiovascular arousal and self‑reported anxiety, little research has compared different caffeine sources within the same individuals or examined whether brief behavioral interventions can buffer these effects. Self‑affirmation, a short writing exercise centered on personal values, has been shown to reduce stress reactivity, but its interaction with caffeine‑induced arousal has not been tested. This within‑subjects study examines how coffee, energy drinks, and a no‑caffeine control influence acute cardiovascular and self‑reported stress responses, and …

Three Bacterial Endophytes Enhanced Plant Growth And Yield And Reduced The Severity Of Phytophthora Capsici In Bell Pepper And Tomato Plants In The Field, Daniel Ambachew, Margaret T. Mmbaga Mmbaga, Richard Hall, Peter Eyegheleme, Mustapha Olawuni, Jamille Robinson, Emily Rotich

Agricultural and Environmental Sciences Faculty Research

Naturally abundant endophytes colonize plants internally without causing harm to their host plants. Endophytes are likely to occupy the same ecological niches as phytopathogens and thus have a high potential to be effective biological control agents. Their demonstrated ability to suppress more than one plant pathogen suggests that they can offer a viable alternative to chemical fungicides and a strategy for decreasing the inoculum potential of soil-borne pathogens. Some biocontrol endophytes are also known to improve soil health and the overall health of plants. However, the results in greenhouse studies do not always translate to consistent field efficacy. In this …

Federalist Politics And The Elusive Original Meaning Of The Free Exercise Clause, Jack Thorlin

Catholic University Law Review

Originalism requires interpreting the Constitution by reference to a provision’s original public meaning. But there is very little evidence of original public meaning for some constitutional provisions, most notably the Free Exercise Clause. Originalists have splintered into several different methodological approaches toward the Clause. Justices Scalia and O’Connor staked out opposing originalist views on the Clause thirty years ago in Employment Division v. Smith and City of Boerne v. Flores. In the Roberts Court, some of the conservative justices have attempted to apply a simple textualist interpretation of the Clause, but those efforts have not attracted most of the …

The Double-Edged Rhetoric Of Parental Rights: Conflicts Between Freedom And Control In Cases Concerning Transgender Youth, Susan Etta Keller

Northwestern Journal of Law & Social Policy

This Article examines the rhetorical structures courts and advocates deploy in two distinct lines of cases adjudicating parental rights claims affecting transgender youth: cases challenging state bans on gender-affirming care, and cases challenging school policies supportive of transgender students. Although the legal basis for the parental rights claims in each set of cases is the same—substantive due process rights under the Fourteenth Amendment—the alignment of parental interests with those of their children diverges between the two sets. In the gender-affirming care cases, parents act in concert with their children’s expressed interests; in the school policy cases, parents seek to override …

The Indiana Statesman, April 23, 2026, Indiana State University

Student Newspaper

Recipients announced for 2026 Faculty Awards; Dr. Melinda Roberts, Dean of the College of Arts and Sciences, will be moving to California State University

Second April 2026 Graduate Council Minutes, University Of Nebraska At Kearney Graduate Council

Graduate Council Minutes

No abstract provided.

Quantification Of Mouse Tracheal Epithelial Cell Differentiation With Cilia Defects, Olivia V. Allen

Honors Thesis

Primary Ciliary Dyskinesia (PCD) is an autosomal recessive disorder that affects 1 in every 7,500 live births. PCD results from motile cilia defects, impairing mucociliary clearance and causing chronic respiratory infections. Our lab studies include three PCD mouse lines — bgh (Spef2), nm1054 (Cfap221), and Cfap54^gt/gt (Cfap54). Prior transcriptomic data led us to hypothesize that PCD mutant mouse tracheal epithelial cells (MTECs) exhibit reduced differentiation into ciliated cells. MTECs from the trachea of the Wild Type (WT) and the PCD mutant mouse lines were cultured at an Air Liquid Interface (ALI) to start …

Dietary Preferences And Food-Seeking Behavior Of Discoid Cockroaches, Blaberus Discoidaliscont., Robert Larsen, Sadie Ariola

2026 Student Academic Showcase

Blaberus discoidalis, also known as discoid cockroaches, inhabit the tropics of South America where their diet consists of leaf litter and decaying organic matter on the ground. This experiment expands on research from two previous years, originally based on the loitering time of the roach's different food types. Such as peanuts, leaf litter, and bananas. The experiment this year was to determine which food was preferred by determining how much it was eaten. Each food item, peanuts, banana, and leaf litter (peanuts alone are crushed) were dried in an oven for 24 hours and weighed before and after each trial. …

Horned Oak Galls And Their Dispersal On Lindenwood's Campus, Peyton Birkenmeier, Timothy Sesterhenn

2026 Student Academic Showcase

Horned oak galls are woody growths found on the branches of oak trees (Quercus sp.). These growths are caused by the parasitic wasp, Callirhytis cornigera. These wasps produce the galls by piercing the branch with their ovipositors and laying eggs into the branch. Based on the severity of infestation, these galls can cause severe damage or even death to oak trees. This research determined the dispersal and severity of horned oak galls infesting the different species of oak trees around the heritage side of Lindenwood. This was done by walking around the heritage side of campus and observing different species …

Effects Of Gibberellic Acid On Mutant Millet, Claire Swiderski, Eric Grant, Kimberly Karlsson, Neil Telfer, Jonathan Becker

2026 Student Academic Showcase

Millets are grasses with small seeds grown as a cereal crop, a major food crop, especially in equatorial regions and in developing countries. Millet plants can develop a dwarfism mutation that leads to less growth and lower yields than normal millet plants. This mutation can be related to a deficiency or insensitivity to a plant growth hormone called gibberellin. We used two experimental groups of millet plants, a control group and a group that received gibberellin treatments. By treating the plants with gibberellin, we observed increased growth in mutant and wild-type millet plants. We measured the length of each plant …

Effects Of Gibberellic Acid (Ga3) On Growth, Height, And Structural Strength In Mutant Setaria Viridis, Gracie Jones, Emma Lewis, Robert Larsen, Alejandro Molina

2026 Student Academic Showcase

Gibberellin (GA3) is a plant hormone that promotes stem elongation and overall plant growth. It increases cell elongation, which results in taller plants. However, increased growth may come at the cost of structural strength. Some mutant plants respond differently to gibberellin depending on whether they are sensitive or insensitive to the hormone. Sensitive mutants lack the ability to produce gibberellin but respond when it is applied, while insensitive mutants do not respond due to defects in hormone signaling. This experiment examines how GA3 affects plant height, panicle development, and structural stability in mutant Setariaviridis.

Neuromuscular Function And Balance In Young Adults: Feasibility And Reliability Of Strength And Conditioning Assessments, Riley Fritzsche, Nicole Waldo Johnson, Jessica M. Moon

2026 Student Academic Showcase

Neuromuscular assessments are widely used in exercise science however; the reliability of comprehensive functional testing batteries in healthy young adults remains unclear. Since sex and hormone status may influence performance, this study proposes that neuromuscular outcomes will differ across males, naturally cycling females, and hormonal contraceptive users. This pilot study will evaluate the feasibility and test-retest reliability of a neuromuscular assessment battery in adults aged 18–35 using a repeated-measures design. Participants will complete two identical testing sessions separated by 5–10 days. Assessments will include balance on force plates, handgrip strength, a 5-repetition chair-rise, and the 3-meter Timed Up-and-Go, alongside neuromuscular …

How Does The Concentration Of Gibberellic Acid (Ga3) Impact The Growth Of Different Setaria Viridis Mutants?, Liz Ritenhour, Gracey Horn, Lawson Veit, Grant Juris, Rodrigo Suarez Almajano

2026 Student Academic Showcase

We tested the relationship between gibberlin and plant growth through the use of gibberellic acid and different dwarf millet variants. Subjects were split into two groups: group one with no gibberellic acid application, and group two with periodic gibberellic application. Each group consisted of 17 pots. Each row held one mutant variant, while the bottom left pot was removed to store water. The objective was to have significant data by the end of the semester to prove the relevant relationship of gibberellin and plant growth.

Dopamine, Addiction, And Cocaine, Addison Delisle

2026 Student Academic Showcase

Cocaine is a powerful stimulant that strongly affects brain function by altering the dopamine system. This project examines both the short- and long-term neurological effects of cocaine, focusing on molecular, cellular, and brain-wide changes. Short-term use increases dopamine in the synapse, causing intense euphoria, heightened alertness, and impaired decision-making. Repeated use leads to long-term changes, including fewer dopamine receptors, structural changes in the prefrontal cortex and striatum, and reduced synaptic plasticity, which contribute to addiction, cognitive problems, and emotional instability. Drawing on neuroimaging, behavioral studies, and molecular research, this project highlights how cocaine progressively reshapes brain circuits. Understanding these effects …

Growth Effects Of Gibberellin Acid On Seteria Viridis, Isabella Calmet, Jamie Karase, Riley Massey, Allsion Schrumpf, Molly Suppa

2026 Student Academic Showcase

This study examined the effects of gibberellic acid (GAs) on growth in dwarf mutant families of Setaria viridis, a model grass species used to investigate hormone-regulated plant development. Dwarf phenotypes in grasses are often associated with disruptions in gibberellin biosynthesis or signaling, making them ideal for evaluating hormone response. Eight mutant families were analyzed using a paired experimental design, where each family was equally distributed between a control group and a GAs-treated group. Seeds were planted in pots with four seeds per pot, maintaining consistent representation of each family across treatments. During the third week of growth, the treatment group …

Effects Of Gibberellic Acid (Ga3) On Growth In Setaria Viridis Mutant Families, Rebecca Laird, Charmaine Dao, Kayneisha Hepburn, Madison Brown, Hailey Veninga

2026 Student Academic Showcase

The grass Setaria viridis has frequently been employed in research due to its short life cycle, small genome, and close relationship to food crops like maize (corn). Setaria is utilized to study the genetic processes governing reproductive development. In this experiment, the effects of gibberellic acid (GA) therapy on several Setaria viridis mutant families have been investigated. This experiment also aims to detect variations in plant height phenotype by comparing GA-treated plants with untreated control plants. The researchers collected and planted eight dwarf millet seeds and one wild type mutant seed and planted in a ‘control’ tray and a ‘treatment’ …

Effects Of Spatially Targeted Fertilizer Strategies On Canopy Growth Across Contrasting Tart Cherry Orchard Sites, Kurt Wedegaertner, Brent Black, Matt Yost, Grant Cardon

Plants, Soils and Climate Student Research

Variable-rate fertilization is increasingly promoted in perennial orchard systems, but its effectiveness remains difficult to predict because tree responses are often inconsistent and strongly conditioned by site-specific constraints. To address this, we evaluated soil-based and vigor-based zoning frameworks across four commercial tart cherry (Prunus cerasus) orchards representing contrasting soil conditions, canopy structures, and management histories. Within each orchard, management zones were defined using either soil apparent electrical conductivity (ECa) or satellite-derived canopy vigor. Fertilization strategies were implemented by varying fertilizer application timing among zones using split-application approaches while maintaining a constant total fertilizer rate. Tree-level canopy structure was …

Liminality And Space In The Iliad And The Heike Monogatari, Jade Simmons

Theses and Dissertations

Both the Iliad and the Heike monogatari have received scholarly attention throughout the years, though rarely in comparison with one another. A few scholars, such as Tyler Creer and Naoko Yamagata, have attempted to examine the two side by side, but very little work has been done beyond their respective analyses. This is unsurprising as a cursory glance at the two texts suggests that they are too separated by time and space to warrant closer examination. I argue, however, that there is great value in analyzing the two side by side. Indeed, a closer look at these texts reveals that …

The Cowl - V. 89 N. 19 - April 23, 2026

The Cowl

The Cowl - student newspaper of Providence College. Vol. 89 No. 19 - April 23, 2026. 16 pages.

Mitochondrial Dna Replication Is Regulated By Endoplasmic Reticulum-Mitochondrial Contact Sites, The Mitochondrial Calcium Uniporter, And Manganese, Amaia Lopez De Arbina, Angelica Zamudio-Ochoa, Mikel Muñoz-Oreja, Diego Perez-Rodriguez, Laura Mosqueira-Martín, Rebecca Lasalandra, Marina Villar-Fernandez, Uxoa Fernandez-Pelayo, Laura Rodriguez-Gomez, Seungtae Lee, Francisco Gil-Bea, Nerea Osinalde, Ainara Vallejo-Illaramendi, Dmitry Temiakov, Antonella Spinazzola, Ian Holt

Department of Biochemistry and Molecular Biology Faculty Papers

Mitochondrial DNA replication occurs at contact sites between the endoplasmic reticulum (ER) and mitochondria (ERMCS). Beyond the known role of the tubular ER protein RTN4, the factors regulating this process are poorly defined. Here, we show that repressing the ER protein ERLIN2 in human fibroblasts depletes ER-mitochondrial contact sites and inhibits mitochondrial DNA replication, as does silencing RTN4 or the ER-mitochondrial tether GRP75. GRP75 or RTN4 scarcity also decreases the level of the mitochondrial calcium uniporter (MCU), whose inhibition blocks mitochondrial DNA synthesis. Because ERMCS depletion did not diminish mitochondrial calcium, and MCU complex can transport manganese, we tested whether …

Montana Kaimin, April 23, 2026, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.