Digital Commons Network^™

Quantitative Fluorescence Imaging Using A Paired Agent Approach For Improving Surgical Decision Making, Sanjana Pannem

Dartmouth College Ph.D Dissertations

Surgical resection remains to be the cornerstone of treatment for most solid tumors, where the primary objective is to remove all visible and microscopic disease. However, the extent of tumor resection is inherently limited by the surgeon’s ability to distinguish tumor from normal tissue, intraoperatively. As a result, positive surgical margins (PSM), where residual tumor remains after surgery, are a common occurrence and are associated with increased recurrence, need for adjuvant therapies, dismal patient outcomes, and high healthcare costs.

Fluorescence guided surgery (FGS) has emerged as a promising technique to enhance intraoperative visualization of tumors and may help reduce the …

Wellness By Design: Leadership And Learning Practices For Well-Being In Arts Management, Ashleigh Olander

Student Theses

Leading with a culture of care is the art of wellness-based design. The arts are often seen as places for healing and community connection; however, arts institutions themselves frequently function in ways that undermine well-being. The systems in place do not promote wellness, nor do they dedicate resources to maintaining the vitality of staff. Wellness initiatives in the arts are ordinarily based on programming, rather than embedded into the foundation of the organization. Although engaging with the arts as a whole elevates wellness, it is challenging to find an arts institution designed with wellness practices in mind. There is a …

Elucidating The Role Of The Gastrointestinal Microbiome And Diet In Dopamine Release In Relation To Attention-Deficit/Hyperactivity Disorder., Meaghan Mcdonald

Celebrating Scholarship and Creativity Day (2018-)

Currently affecting 340-580 million people worldwide, ADHD is a neurodevelopmental disorder that affects how the brain controls attention, behaviour and impulses often beginning in childhood and continuing into adulthood. ADHD is known to be associated with monoamine neurotransmitters including dopamine. This work aims to uncover the ways in which metabolism of monoamine precursors in the gastrointestinal microbiome influences dopamine release in the brain. Previous studies have indicated that children with ADHD display distinct gut bacteria profiles with unique microbiota species that result in the disruption of monoamine precursor pathways of phenylalanine and tyrosine metabolism. Emphasis on our western diet and …

Sociocultural Change And The Prevalence Of Chronic Diseases Among Women In Arabian Gulf Countries: Kuwait As An Example, Yagoub Y. Al-Kandari

Journal of Arts and Social Sciences

This study aims to examine the effect of modernity and the prevalence of chronic diseases among women in Kuwait as an example of Arabian Gulf countries. A total of 5,749 married and previously married women aged 18–79 years were selected from 10 primary health care clinics out of 50, using a stratified random sample. A questionnaire was the major tool of this study. The questionnaire included some sociocultural and health variables. Information about age, level of education, governorate, family income, job position, the respondents’ and their parents’ types of marriage, and ethnic groups were collected. Respondents were asked to self-report …

The Role Of The Ventral Tegmental Area In Reward And Addiction: A Comprehensive Review, Emad Ali Albadawi

Neurosciences

The ventral tegmental area (VTA) is a central hub in reward and motivation, integrating heterogeneous neuronal populations and projection-defined circuits to regulate learning, decision-making, and addiction. This review synthesizes anatomical organization and cellular diversity (dopaminergic, GABAergic, and glutamatergic neurons, including multitransmitter co-release), and maps major efferent pathways constituting the mesolimbic and mesocortical systems. We highlight computational roles of VTA activity, including reward prediction errors, incentive salience, and context memory integration, and summarize drug class-specific mechanisms that perturb VTA output. We then outline time-dependent neuroadaptations across mesocorticolimbic networks and discuss therapeutic implications spanning pharmacological, behavioral, and emerging circuit-targeted interventions. Together, these …

Neuroinflammation At The Crossroads Of Neurodegeneration: The Roles Of Microglia And Astrocytes In Parkinson's Disease, Alzheimer's Disease, And Multiple Sclerosis, Mohannad A. Almikhlafi

Neurosciences

Neuroinflammation plays a critical role in the pathogenesis of neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, and multiple sclerosis. This review explores the underlying mechanisms of neuroinflammation, with a focus on the roles of microglia, astrocytes, peripheral immune cell infiltration, and cytokine release. The complex interplay between oxidative stress and chronic inflammation accelerates neurodegeneration, contributing to disease progression. Microglial activation, initially protective, becomes harmful when sustained over time, driving chronic inflammation. Similarly, astrocytes once considered passive are now recognized for their active involvement in both inflammatory and neuroprotective responses, depending on their activation state. Prolonged activation of microglia and …

Role Of Bevacizumab In Multiple Glioblastomas: A Retrospective Single-Center Analysis, Yongrui Zhao, Yidong Chen, Leiming Wang, Ye Cheng, Feng Yan, Jiankun Xu

Neurosciences

Objective: To explore the prognostic factors of multiple glioblastomas (M-GBMs) and the role of bevacizumab (BEV) in M-GBMs. Methods: 162 patients treated for primary glioblastoma (GBM) from 2020 to 2024 were retrospectively reviewed. Kaplan–Meier analysis was performed to compare progression-free survival (PFS) and overall survival (OS) between the single glioblastoma (S-GBM) group and the M-GBMs group. Independent predictors of OS among M-GBMs patients were evaluated via multivariable Cox regression analysis. Results: 116 patients had S-GBM, and 46 had M-GBMs. Compared with S-GBM patients, M-GBMs patients had poorer PFS (6.5 vs. 11 months, p<0.001) and OS (15.5 vs. 21 months, p=0.005). In the M-GBMs group, based on the RANO resection criteria, both univariable analysis and multivariable Cox models confirmed that the extent of resection, use of radiotherapy and chemotherapy, p53 overexpression, and use of BEV were all factors that significantly influenced OS. Specifically, the use of BEV prolonged OS from 12 months to 19.5 months (p = 0.017). From the initiation of BEV therapy, the median PFS was 5.5 months (95% CI 4.45–6.56 months), and the median survival was significantly longer than in those who did not received BEV (10 vs. 3 months, p = 0.021). Conclusion: The extent of resection, radiotherapy/chemotherapy, p53 …

Catalyzing Learner-Centered Ecosystems In Pennsylvania For A Future Of Human Thriving, Danielle S. Shylit

Graduate Theses & Dissertations

School-centric education has failed to produce equitable outcomes for Pennsylvania's learners. Declining student engagement, widening opportunity gaps, and the demoralization of educators and leaders escalate an urgent need to shift systems, mindsets, and praxis from a school-centric to a learner-centric paradigm. This action research dissertation elevates what is learned at individual, group, and system levels through disciplined inquiry with aligned district public education leaders in Pennsylvania willing to co-create learner-centered ecosystems with community stakeholders for a future of human thriving. Grounded in Education Reimagined's definition of Learner-Centered Ecosystems, and the theoretical frameworks of Bryk et al.'s Networked Improvement Communities and …

Facilitating Student Success Through Scholar Programs, Jenna Heath, Isabella Shenouda

College of Liberal Arts Faculty Research

This poster features a series of career highlights from the UNLV Engelstad Scholars Program. This document profiles four exceptional current and former students—Fyona Mortel, Nikki Adams, Jordan Paul Guimarey, and Haydee Herrera—who demonstrate how the program's unique blend of mentorship, financial support, and community engagement accelerates career readiness. Through hands-on internships, leadership roles, and diverse professional networking opportunities, these scholars have cultivated essential competencies such as leadership, critical thinking, empathy, and professional branding, effectively preparing them for future success in their respective fields.

From Dissent To Terrorism: The Formation Of A Security Grammar In Malaysia, Haezreena Begum Binti Abdul Hamid Dr

Indonesia Law Review

The absence of a universally accepted definition of terrorism has enabled states to exercise wide discretion in naming, governing, and exceptionalising violence. This article argues that, in Malaysia, “terrorism” did not emerge as a neutral legal category but as the product of a historically evolving security grammar, a patterned way of interpreting ideology, dissent, and conflict through the lens of existential threat. Employing a qualitative doctrinal socio-legal methodology, the study integrates analysis of international and Malaysian legal frameworks with case-based examination of key episodes, including Memali, Al-Arqam, Al-Ma’unah, Lahad Datu, and ISIS-linked incidents. Statutes, judicial decisions, policy materials, and regional …

Examining The Psychometric Structure Of An Instrument To Measure Students’ Interests And Motivation In Science Learning: Factor Analysis And Measurement Invariance, Fuhui Tong, Shifang Tang, Zhuoying Wang, Beverly J. Irby

Faculty Publications

In this study, we examined the psychometric properties (reliability, validity, and underlying factor structure) and measurement invariance of a researcher-developed instrument: Motivated Strategies for Science Learning (MSSL). Data were collected from 2765 fifth-grade students across [state withheld] school districts. Results from exploratory and confirmatory factor analyses suggested satisfactory psychometric properties of MSSL. We further identified strong evidence to support configural, metric, scalar, and strict invariance across school location groups (i.e., rural and non-rural), confirming that the instrument can accurately capture the construct of science learning motivation among fifth-grade students from both rural and non-rural Texas schools. The study provides the …

Socializing Stem: Analyzing The Effects Of Stem Pedagogy, Communication, And Culture On Stem Student's Holistic Development, Jalynn B. Whitfield

Honors Capstone Projects and Theses

No abstract provided.

Liquid Modernity Off-Modernity: A Pop-Up Interior In The Middle Of Nowhere, Ayman Kassem

ARSNET

This visual essay examines the pop-up desert café as a contemporary interior condition shaped by mobility, reversibility, and performative occupation. Framed through Bauman’s (2000) liquid modernity and Branzi’s (2002) diffuse modernity, it argues that temporary desert setups are not informal exceptions but design responses to unstable, event-based ways of living. The essay reads the pop-up as a hybrid interior-exterior assemblage, where carpets, furniture, lighting, signage, and social rituals produce atmosphere and collective presence. Using collages on photography taken by the author-co-created with architect Moustafa Abdulwahed—as a method, the visual essay journey moves from photographic observation to extraction and speculative recomposition, …

2025 Annual Report, Tennessee. Bureau Of Investigation.

Annual Report

No abstract provided.

Vulnerability Of Bass Populations To Our Changing Climate In The Mississippi River, Cameron Schreifels

Celebrating Scholarship and Creativity Day (2018-)

Climate change is altering habitats and damaging bass populations throughout the Mississippi. The main factors of climate change affecting bass are shifts in water quality and significant weather events, which have increased bass vulnerability. With rising temperatures and eutrophication changing the way these bass hunt for their prey, it has made it easier for other non-native species to encroach on their habitat, which has led to bass further encroaching on other species due to climate change.  Given their economic importance and cultural significance, better management practices are needed to find new ways to protect them and ensure they remain a …

Inhibition Of The Pi3k/Akt/Mtor Pathway In Non-Small Cell Lung Cancer, Gretchen Gunderzik

Celebrating Scholarship and Creativity Day (2018-)

The phosphatidylinositol 3-Kinase (PI3K)/protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) signaling pathway is a cell survival pathway that is commonly unregulated in non-small cell lung cancer (NSCLC). Current inhibitors of this pathway often face the challenge of inherent and developed resistance. There is the need to further develop a targeted treatment therapy focused on inhibition of this signaling pathway. This could synergistically enhance commonly used cancer therapies such as chemotherapy, which NSCLC patients often develop resistance to. Due to the complexity of the pathway, dual inhibition is an intriguing avenue of research as it helps to mitigate resistance from …

The Big Picture Of The Small Intestine, Reagan Kangas

Celebrating Scholarship and Creativity Day (2018-)

Histology is the study of microscopic tissue structures and is used to understand the function of tissues and visualize the cellular organization within them. It is an important tool in biology and medicine, used for diagnosing disease (i.e., cancers, infections, inflammatory diseases, etc.) and studying organ structure and function. The goal of this poster is to compare preparation and staining techniques, specifically paraffin versus frozen sectioning methods, along with Masson’s trichrome versus hematoxylin and eosin (H&E) staining. These methods differ in processing time, tissue preservation, and the level of detail they reveal under a microscope. This project uses small intestines …

Survival Of The Fittest: Extremophilic Actinomycetes As The Future Of Antibiotic Treatment, Ben Reddan, Kyley Nelson

Celebrating Scholarship and Creativity Day (2018-)

The antibiotic resistance crisis is an emerging global health threat. In 2019 alone, 1.27 million deaths were attributed to antibiotic-resistant pathogens, and researchers predict the problem will worsen without intervention. Methicillin-Resistant Staphylococcus aureus (MRSA) has become a primary model for this crisis because it utilizes genomic adaptations to bypass β-lactam antibiotics. Although temperate actinomycetes have historically provided the majority of clinical antibiotics, recent bioprospecting has revealed that extremophilic actinomycetes represent a critical untapped resource. These organisms exhibit several adaptations to thrive in extreme environments, which results in the production of novel secondary metabolites and resilient extracellular enzymes. This literature review …

The Impact Of Hybrid Insulin Peptides On The Two-Phase Decline Of C-Peptide In Type 1 Diabetes, Ashley Mehl

Celebrating Scholarship and Creativity Day (2018-)

This research aims to determine how the formation of hybrid insulin peptides (HIPs) contributes to the two-phase decline of C-peptide production in type 1 diabetes (T1D). C-peptide is used to determine the level of insulin production within human pancreatic beta-cells because it is secreted in equimolar amounts with mature insulin peptide. The two-phase decline is characterized by an initial rapid and exponential loss of beta-cell function, followed by a prolonged plateau phase of residual insulin secretion. During this plateau phase, residual beta-cells continue to generate HIPs through both enzymatic transpeptidation and spontaneous formation via anhydride intermediates. These processes are problematic …

Fiber Content, Total Sugar, And Glycemic Index Of Jackfruit Seed And Pigeon Pea Flour Snack Bar, Dhiyaa Septi Kirana, Tesa Rafkhani

Indonesian Journal of Public Health Nutrition (IJPHN)

Diabetes Mellitus (DM) in Indonesia is the 7th leading cause of death. Diets high in sugar and glycemic index, and low in fiber are known to trigger hyperglycemia. Snack bars high in fiber and low in glycemic index are known to reduce blood glucose levels. This research aims to determine a snack bar formulation made from jackfruit seed and pigeon pea flour and analyze fiber content, total sugar, and glycemic index value. This study used a completely randomized design analyzing three different proportions of jackfruit seed and pigeon pea flour, namely F1 (30%:70%), F2 (40%:60%), and F3 (50%:50%) with two …

The Relationship Between Parenting Styles And Breakfast Habits With Adolescent Eating Behavior, Nailul Nufarohah, Siti Soraya, Hilda Carmitha Panjaitan

Indonesian Journal of Public Health Nutrition (IJPHN)

Adolescence is a critical transitional period requiring adequate and balanced nutrition to support optimal physical growth and psychosocial development. However, unhealthy Eating Behaviors such as skipping breakfast, consuming unbalanced diets, and frequent intake of foods high in sugar, salt, and fat are still commonly observed. Parenting styles and breakfast habits are considered important factors influencing adolescents’ Eating Behavior. This study aimed to analyze the relationship between parenting styles and breakfast habits with Eating Behavior among adolescents. This study employed a quantitative approach with a cross-sectional design conducted at SMK Negeri 62 Jakarta, South Jakarta. The population consisted of 578 active …

Prevalence Of Polypharmacy And Its Association With Adverse Drug Effects Among Elderly Individuals In An Urban Field Practice Area Of A Tertiary Care Institution In South Kerala, Ajas Sn, Shameer Hakkim, Asha Raby N

Muthanna Medical Journal

Background: Polypharmacy (≥ 5 medications) is increasingly common among the elderly due to multimorbidity, longer life expectancy, and fragmented care, and is linked to adverse drug effects (ADEs). In urban Thiruvananthapuram, community-level evidence on its burden and ADE association is limited.This study was done to estimate the prevalence of polypharmacy among community-dwelling elderly and examine its independent association with self-reported ADEs. Methods: A community-based cross-sectional analytical study (March–December 2024) was conducted among 420 elderly individuals (≥ 60 years) selected via systematic random sampling. A validated interviewer-administered questionnaire (CVI = 0.94; ICC = 0.87) assessed medication use (past 30 days), ADEs, …

Reclaiming The Writing Process Using Ai: A Scaffolded Writing Assignment That Promotes Critical Thinking, Reflection, And Accountability, Hannah M. Schapiro, Manuela Tripepi, Julia Blackley

College of Life Sciences Faculty Papers

As the educational landscape changes with the widespread use of generative artificial intelligence (AI), we have made the deliberate choice to adapt with intention through the constructive integration of this tool within the curriculum. Writing assignments are often vulnerable to AI shortcuts, and therefore, we reimagined the project in our online microbiology lab to incorporate AI in a structured and pedagogically sound way that prioritizes both the writing process and the final product. Students must work with AI to create a script for a 5-minute video which they then illustrate and record on the differences between Staphylococcus aureus and methicillin-resistant …

The Hollywood Rap And Trap Culture Industry And Its Portrayal Of Crime, Youth Socialization, And Anti-Social Behavioral Norms, Ishika Sen

Honors Theses

This thesis synthesizes and reflects on media effects and hip-hop studies to examine how the Hollywood rap/trap industry participates in the influence of normalization of crime and anti-social behaviors, substance use, and the sexualization of women among youth (ages 13–21). I integrate analytic evidence on media violence with lyric/content analyses of rap and critiques of the criminal justice system in hip-hop. Specific subtopics from my outline include: theoretical frameworks (media-violence, social learning, cultivation, cultural criminology); corporate marketing and social-media amplification; youth vulnerability; and three patterned domains which include substance abuse, gun violence, and the sexualization of women, often leading to …

Subtitling Strategies For Translating Korean Terms Of Address Into Indonesian, Annisa Puji Lestari, Usmi Usmi

Multikultura

This study examines the subtitling strategies used in translating Korean terms of address into Indonesian, with a focus on how sociocultural meanings embedded in Korean address systems are conveyed in the target language. Employing a descriptive qualitative approach, the study analyses a corpus of dialogue excerpts taken from two Korean drama series. The findings identify seven categories of address terms: proper names, occupational titles, kinship terms, common nouns, attention-getters, pronouns, and child name-derived forms. Proper names are the most frequent category, followed by occupational titles, kinship terms, common nouns, and attention-getters, whereas pronouns and child name-based forms occur less frequently. …

Makna Simbol Hewan Dalam Peribahasa Arab Di Media Sosial, Farwah Sofwatun Nida

Multikultura

It is known that proverbs have existed for a long time, but today researchers have identified many proverbs, especially those that use animal symbolism, and these proverbs are being republished on social media. This study aims to analyze the meanings and origins of these proverbs so that we can understand the context of their current use on social media. The research was conducted using a qualitative method with an in-depth semantic approach. Data were collected through social media research techniques, drawing from YouTube, Facebook, and Instagram. The findings indicate that animal symbols in Arabic proverbs contain both negative and positive …

Kehidupan Berpasangan Di Prancis Dan Pergeseran Nilai Sosial, Febriliani Rahmanda, Airin Miranda

Multikultura

This article discusses how legal discourse related to PACS in France reflects and shapes social norms and values that develop in society, particularly in relation to the existence of the mariage pour tous law which was passed fourteen years after the PACS was passed. Both laws were passed by the French government aimed at heterosexual and homosexual couples in order to create equal rights for its citizens. The purpose of this study is to show PACS in France and its relationship to changing social norms, particularly after the passage of the mariage pour tous law in 2013. The theory used …

The Cowl - V. 89 N. 20 - April 30, 2026

The Cowl

The Cowl - student newspaper of Providence College. Vol. 89 No. 20 - April 30, 2026. 32 pages.

The Mapping Of Huma Betang Character In Physics Learning Based On Machine Learning (Artificial Neural Network And Fuzzy C-Means), Pri Ariadi Cahya Dinata, Desy Kumala Sari, Theo Jhoni Hartanto, Gunarjo Suryanto Budi

Jurnal Pendidikan dan Pembelajaran

Background: Huma Betang (big house) is a philosophy of the Dayak community and serves as a value instilled in learning at schools in Central Kalimantan. While numerous studies have explored the application and inculcation of Huma Betang character values in students, few have quantitatively measured and mapped these characters as part of educational evaluation. Objective: This study aims to map the profile of the Huma Betang character in Physics learning among high school students in Palangka Raya City, Central Kalimantan. The characters measured in this study consist of four pillars: Hapahari (kinship), Handep (mutual assistance), Belom Bahadat (civilized living), and …

Meeting Students’ Basic Needs Through A Free Nutritious Meal Program At School, Wiedya Listrina, Nora Saiva Jannana, Sedya Santosa, Tarwiyati Tarwiyati, Aning Puspita Ningrum

Jurnal Pendidikan dan Pembelajaran

Background: The effectiveness of school-based nutrition intervention programs in improving students’ readiness to learn continues to yield mixed results, particularly when implemented in educational settings with heterogeneous social characteristics. Objective: This study aims to analyze the fulfillment of students’ basic needs through the Free Nutritious Meal Program (MBG) and its implications for learning readiness and the learning climate at MTs Hidayatullah, Temanggung Regency, Central Java. Method: This study employs a qualitative approach with a case study design. Participants included eight students, four teachers who also served as homeroom teachers, the school principal, and the program coordinator, all selected through purposive …