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Discipleship Includes Both Acceptance And Change, Steve Case

Journal of Adventist Youth and Young Adult Ministries

Discipleship—following Jesus—includes both acceptance and change. Acceptance from Christ transforms the orientation of humans to follow the God who initiates and completes our acceptance. But discipleship also involves change—sometimes radical and sometimes gradual. The transformation that began with acceptance continues with change. An emphasis of one over the other, or worse, ignoring or denying one of these two dynamics, results in a skewed discipleship. Both acceptance and change remain supernatural actions in the God-human relationship of discipleship.

Generational Interpretations Of Feminism: A Qualitative Study Of Women’S Perspectives, Molly Sabia Msw

All Student Scholarship

The current study gathered information on how women across five generations interpret feminism. Nine women were interviewed: (2 per generation, except the silent generation was 1). Understanding how women across five generations interpret feminism helps determine whether perspectives of feminism are due to a difference in time period or other variables. Based on research that has been conducted, we know that there are different views and interpretations of feminism on a broad scale; this study dove into participants’ perspectives and generational influence.

The preliminary findings of this study suggest there are some areas of the Feminist Movement that exhibit generational …

Design And Synthesis Of Polyphenolic Hemibastadin Derivatives As Potential Biofilm Inhibitors, James Daniel

Longwood Senior Theses

Antimicrobial agents are one of the most important therapeutics used in the medical field. With the rising prevalence of antibiotic resistant bacteria, new strategies have been developed to combat them, with biofilm-inhibiting agents proving to be promising candidates. A class of molecules known as hemibastadins, first discovered from marine sponges, has garnered significant attention for their biofilm properties. This thesis investigates the synthesis of three derivatives of hemibastadin-1, which incorporate structural changes meant to improve their biofilm-inhibiting properties and biological safety. The selected modifications to the structure of hemibastadin-1 include the replacement of the brominated phenols with a safer polyphenolic …

Diacylglycerol Kinase Eta As A Novel Target In Nras Mutant Melanoma, Haley P. Wilson, Casey D. Stefanski, Signe Caksa, Glenn L. Mersky, Scott D. Varney, Jelan I. Haj, Dan A. Erkes, Timothy J. Purwin, Vivian Chua, Andrew E. Aplin

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

NRAS mutations occur in 10%-30% of cutaneous melanomas and are associated with high tumor mutational burden. Mutant NRAS signaling drives aberrant cell growth and proliferation, in part, through activation of the RAF-MEK-ERK1/2 kinase pathway; however, targeted therapies to this pathway have limited effectiveness in patients with NRAS mutant melanoma. The role of other targetable signaling pathways in NRAS mutant melanoma is poorly characterized. Here, we demonstrated that one isoform of diacylglycerol kinase, diacylglycerol kinase eta (DGKη), a lipid signaling regulator, was highly expressed in NRAS mutant melanoma patient samples. Knockdown of DGKH in NRAS mutant melanoma cell lines resulted in …

Are College Students Thinking Twice About Having Kids? How Political Factors May Affect The Future Birth Rate In The United States, Gloria Flores

Theses and Dissertations

The trend of the birth rate decline is an important phenomenon which has attracted scholarly attention in the United States. Prior research has explored factors such as income, education, and personal preferences. However, there is minimal research on how the political environment affects people’s family planning decisions. That is, in what ways might perceptions of modern politics affect whether people decide to have children? The limited amounts of research in other countries focusing on political efficacy and its effects on people’s decision to have children have found that people are highly sensible about their political environment when it comes to …

May 2026 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Employee Perspectives Of Addiction: Effects On Workplace Dynamics, Alex Silverman

Theses and Dissertations

This study examined how employees perceive and respond to coworkers experiencing substance use disorders (SUDs) and behavioral addictions in workplace settings. Integrating attribution theory, stigma frameworks, and Quality of Work Life (QWL) perspectives, a controlled vignette-based design was administered to 130 employed adults who evaluated hypothetical coworkers across addiction conditions. Multilevel modeling revealed that SUDs were perceived as more severe than behavioral addictions, and higher perceived addiction severity was associated with greater stigmatizing attitudes. Stigmatizing attitudes, in turn, were differentially associated with workplace behavioral responses: stigma was strongly associated with increased distancing and reporting behaviors but was not significantly associated …

Aircraft Fault Detection Via Weight And Bias Analysis Of A Custom First Neural Network Layer, George Harrison Chen

Theses and Dissertations

Fault detection in aircraft is traditionally handled through redundant hardware and comparison algorithms to detect failures. Alternatives like model-based residual generation and data-driven approaches such as supervised fault classification and unsupervised anomaly detection have been explored, but they suffer from practical limitations; model-based methods require accurate system models, and data-driven methods have large constraints on the data limiting scalability and adaptability. This work presents a purely data-driven neural network architecture featuring a custom first layer designed for real-time fault detection where the weights and biases of this layer are used to detect faults. The network requires zero supervision and complements …

Effects Of M6a Dna Methylation By Bacterial Methyltransferase In Colorectal Cancer, Fabian Alejandro Mendoza Galvan

Dissertations and Theses (Open Access)

Effects of m6A DNA methylation by bacterial methyltransferase in colorectal cancer Fabian Alejandro Mendoza Galvan Advisory Professor: Angela H. Ting, Ph.D. Fusobacterium nucleatum animalis (Fna) is found in the human oral cavity and gut. A distinct clade of Fna is primarily enriched in the tumor microenvironment (TME) and within colorectal cancer (CRC) cells. This clade DNA methylation pattern is primarily catalyzed by a cell-cycle regulated methyltransferase (CcrM) ortholog, M.FnI, that targets the GANTC sequence motif through methyl-6-Adenine (m6A) DNA methylation. We hypothesized that M.FnI enzyme can induce m6A methylation abnormalities in CRC cells to promote cancer progression. Evidence for endogenous …

Targeting Breast Cancer Brain Metastasis Through Novel Combination Of Fda-Approved Orally Active Blood-Brain Barrier Permeable Ret And Tgli1 Inhibitors, Joshua Cha

Dissertations and Theses (Open Access)

Breast cancer is the most diagnosed cancer in American women, and breast cancer brain metastasis (BCBM) exhibits the worst prognoses with a life-expectancy averaging at 6 months. This short life expectancy is largely attributed to the lack of effective treatment. Many challenges remain unsolved, including the limited number of actionable targets for targeted therapy and effective blood-brain barrier (BBB) permeable drugs that are safe without promoting drug resistance. Therefore, there is an urgent call for identification of novel therapeutic targets and development of BBB-permeable drugs. One of the potential targets identified by our lab for BCBM targeted therapy is the …

Pattern Dynamics And Stochasticity Of Brain Rhythms And Spike Trains In A Tauopathy Mouse Model Of Alzheimer’S Disease, Clarissa M. Hoffman

Dissertations and Theses (Open Access)

Systems neuroscience posits that every aspect of perceived physical reality, every aspect of animal and human behavior, and every cognitive phenomenon emerges from patterns of neuronal activity. While most researchers embrace this idea, there are major difficulties in describing and analyzing these complex neuronal dynamics—spike flows produced by cells ensembles, synchronized extracellular field oscillations, and other patterns—which limits our understanding of how the activity of individual neurons and the whole-animal cognition and behavior might be connected. In particular, we lack the approaches and even the semantics for connecting the individual cell outputs and the integrated results of their activity. Current …

Characterization Of Staphylococcus Aureus Clinical Isolates From Deep Musculoskeletal Infections For An In Vitro Biofilm Model For Phage Therapy, Raquel C. Luna

Dissertations and Theses (Open Access)

The rise of multidrug-resistant (MDR) infections is a growing concern in the treatment of deep musculoskeletal infections (MSKIs) and orthopaedic device-related infections (ODRIs). Staphylococcus aureus is responsible for about one third of these infections due to its strong biofilm forming capacity, presence on human skin, and the large number of antibiotic-resistant variants. Bacteriophage (phage) therapy is now being considered as a treatment for MDR MSKIs/ODRIs. We are investigating the use of phage encapsulated into or adsorbed onto biodegradable microspheres for local delivery to the site of these MDR infections. We determined that the anti-staphylococcal phage K effectively lyses the S. …

From Antigen Presentation To Tumor Control: Mechanisms Of Type I Conventional Dendritic Cell-Based Cancer Vaccines, Josue E. Pineda

Dissertations and Theses (Open Access)

Type 1 conventional dendritic cells (cDC1s) are important for generating and sustaining antitumor immunity. Accordingly, the abundance of cDC1s in human tumors correlates with improved outcomes in cancer. Capitalizing on this role, we previously demonstrated that vaccination with in vitro-derived murine cDC1s elicits durable tumor control in multiple preclinical models; however, the immunological mechanisms underlying the efficacy of cDC1 vaccination remain unclear. Here, we examined whether in vitro-derived cDC1s resemble tumor-infiltrating DC populations and whether MHC-I and MHC-II antigen presentation contribute to cDC1-mediated tumor control following vaccination in melanoma.

As expected, MHC-I- or MHC-II-deficiency had minimal impact on …

Membrane Organization Of Rheb And Rhoa: Roles In Function And Allosteric Druggability, Chase M. Hutchins

Dissertations and Theses (Open Access)

Small GTPases of the Ras superfamily are membrane-bound molecular switches that regulate nearly all major cellular processes, and their dysregulation drives cancers, neurological disorders, and metabolic diseases. While anchored to cellular membranes, the catalytic domains of small GTPases undergo orientation dynamics, adopting distinct configurations that can occlude or expose effector-binding surfaces and modulate signaling output. These dynamics have been characterized in the Ras oncoproteins, but whether they extend across the superfamily and influence allosteric druggability has remained unknown.

In this dissertation, I address these questions through Rheb and RhoA, two small GTPases with complementary differences in subfamily lineage, membrane localization, …

Understanding Epigenomic Landscapes In Cancer Progression And Immunotherapy Response, Jonathan Schulz

Dissertations and Theses (Open Access)

Nonmutational epigenomic reprogramming has emerged as a key hallmark of cancer that plays crucial roles in tumor evolution during its progression and response to therapy. However, the extent and nature of epigenomic reprogramming remains poorly understood. This dissertation examines how epigenetic regulation shapes cancer progression and response to immunotherapy. Working at the intersection of cancer biology and computational genomics, it develops analytical frameworks for characterizing chromatin structure and DNA methylation across diverse tumor contexts and uses these frameworks to address two complementary biological questions: how promoter-associated chromatin organization varies across cancer types, and how epigenetic perturbation modulates tumor immunogenicity in …

An Integrated Framework For Early Detection And Transmissibility Assessment Of Emerging Variants In Wastewater, Xingwen Chen, Tin Phan, Wei Lin Lee, Katie Clark, Steven F Rhode, Samantha Brozak, Bruce Pell, Tsultrim Palden, Mats Leifels, Anna Gitter, Yang Kuang, Stefan Wuertz, Janelle Thompson, Kristina D Mena, Eric J Alm, Fuqing Wu

Faculty, Staff and Student Publications

Tracking the emergence of new viral variants is critical for epidemic preparedness, but remains challenging because variants typically circulate at low prevalence during the early phase of outbreaks. Here, we present an integrated framework that combines sensitive variant detection in wastewater with quantitative assessment of transmissibility through dynamic epidemic modeling. Using the SARS-CoV-2 Omicron variant as a proof of concept, we developed a novel nested allele-specific RT-qPCR assay (NAS-PCR) that achieved a thousand-fold increase in sensitivity compared with allele-specific RT-qPCR (limit of detection: 0.5 copies/μl). NAS-PCR detected Omicron in wastewater samples from the Greater Boston area starting in September 2021, …

Securing Cloud-Native Systems: From Vulnerability Analysis To External And Insider Threat Detection, Jiongchi Yu

Dissertations and Theses Collection (Open Access)

Cloud-native systems have become the backbone of modern software infrastructure. However, their dynamic resource orchestration and complex configurability introduce a large attack surface and intricate security challenges. Adversaries can externally exploit vulnerabilities in cloud components or perform insider movement within cloud environments to launch attacks. As these systems increasingly support critical services, security breaches can lead to severe operational and economic consequences.

Despite extensive efforts in vulnerability detection and attack monitoring, existing approaches struggle to remain effective in cloud-native environments characterized by rapid evolution and inherent heterogeneity. In particular, they exhibit three fundamental limitations: (1) Insufficient understanding of defect patterns …

Body And Blood: The Black Catholic Imagination In Toni Morrison's Novels, Allison Schneider

FCRH Honors Program Theses

Religion was a powerful shaping force in Toni Morrison’s life, so it should come as little surprise that it shaped her art, as well. From the personal to the academic, her religious experiences deeply inspired her writing, and the spiritual dimension of her work has become a prominent topic among Morrison scholars. Despite a vast body of research dedicated to the religious in her novels, the prevalence of Catholic themes in Morrison’s novels remains largely unexplored. Born and raised in Lorain, Ohio, Morrison grew up surrounded by different faith traditions. Her mother belonged to the African Methodist Episcopal (AME) Church, …

Generative Ai Of Breast Cancer Progression In Gene Expression Space, Xusheng Ai

All Dissertations

Breast cancer is one of the most common and deadly cancers in the world. Although doctors can use gene activity data to better understand different types of breast cancer, it is still difficult to identify the most important genes and to track how the disease changes over time. This is partly because gene data are very large and complex.

This dissertation develops a computer-based framework to study breast cancer using gene expression data. The work focuses on three goals: creating realistic synthetic gene data, identifying important genes linked to cancer, and modeling how breast cancer changes from normal tissue to …

Using Large Language Models To Assess Entrepreneurial Personality In Generation Z College Students, Xianyong Wang

All Dissertations

As entrepreneurial personality (EP) plays a critical role in Generation Z’s (Gen Z) long-term success, it is crucial to understand the EP of Gen Z college students. To date, little is known about what EP is and how it can be assessed in Gen Z. Therefore, this dissertation presented two sequential studies to address two closely related research foci. The first study examined the scope and dimensionality of EP in Gen Z college students using topic modeling. In the second study, pre-trained LLMs were fine-tuned to predict self-reported EP levels from personal narrative responses. To collect data, college students (N …

Refining Treatment Thresholds Of Insect Pests In South Carolina Soybeans Using Simulated Injury And Natural Populations, Adam Whitfield

All Dissertations

Insect pests are a major limiting factor to profitable soybean, Glycine max (L.) Merr., production in South Carolina, yet current economic thresholds are largely based on historical data and may not reflect modern cultivars, production practices, or input costs. Key insect pests in South Carolina can be categorized into three major feeding groups: defoliators, stem feeders, and pod feeders. Defoliating insects include, but are not limited to, soybean looper, Chrysodeixis includens (Walker); velvetbean caterpillar, Anticarsia gemmatalis (Hubner); green cloverworm, Hypena scabra (Fabricius); grasshoppers; and numerous species of beetles. Stem feeders include, but are not limited to, kudzu bug, Megacopta cribraria …

Abnormal Trafficking And Processing Of Multiple Matrix Metalloproteinases Drive Cartilage Defects In Congenital Disorders Of Glycosylation, Chia-Lun Wu

All Dissertations

Congenital Disorders of Glycosylation (CDG) are rare metabolic diseases caused by defects in glycosylation. Despite identification of over 200 CDG types, the mechanisms linking glycosylation defects to diverse clinical phenotypes remain unclear. This dissertation uses zebrafish models of PMM2-CDG and STT3-CDG to redefine CDG pathogenesis, shifting from a simple glycan deficiency model to one involving disrupted cellular spatial organization.

We identify a protease-dependent pathway underlying craniofacial cartilage defects. Specifically, defective proteolytic processing of N-cadherin, a key adhesion molecule in chondrogenesis, is a central driver of pathology. We further uncover an unconventional trafficking mechanism in which ER stress and altered secretory …

The Impact Of Label Material On Perceived Value And Environmental-Friendliness Of Beverages In Returnable Glass Bottles Versus Actual Environmental Impact Via Life Cycle Assessment, Toni Sharp

All Dissertations

With guidance from the EPA to reduce virgin packaging use and alternatively increase reuse, the concept of reusable packaging has re-emerged as a potential sustainable alternative to single-use and recyclable packaging. For businesses, an understanding of the potential environmental benefits of switching from single-use packaging to reusable packaging, along with consumer willingness to pay for sustainable packaging are paramount. Existing literature on willingness to pay (WTP) for ethical or sustainable products typically relies on consumers’ stated preferences found through surveys using hypothetical products and prices. It has been revealed that sustainability claims printed on the label or products in glass …

Assessing Neurodiverse Inclusion In Zoos, Aquariums, And Nature Centers: A Secondary Analysis Of The Mozaics Project, Jennifer N.K. Garcia

All Dissertations

Playful experiences are found to promote positive youth development (Burdette & Whitaker, 2005; Gray, 2011; Sobel, 2018; Watchman & Spencer-Cavaliere, 2017). Additionally, playing in nature can improve attention and mood and reduce stress (Greenleaf, 2014; Kaplan & Kaplan, 1989; Shin & Swank, 2018; Ulrich ,1991). Unfortunately, neurodiverse youth, especially those with autism, can often experience barriers that limit access to play (Pynn et al., 2018; Stern, 2003) specifically play in nature (Barnes, 2007; Wolfberg, 2009). Yet, community organizations that offer playful experiences in nature, such as zoos, aquariums, and nature centers, could be uniquely positioned in the community to support …

Baseline Cervical Intervertebral Disc Biomechanics And Implications For Allograft Preservation, Nathan F. Buchweitz

All Dissertations

Neck pain has become an increasingly common orthopaedic healthcare issue. Evidence shows that degeneration of cervical intervertebral discs (the cartilage between the spinal vertebrae in the neck) may be associated. While disc degeneration in the lumbar spine has been extensively studied in relation to low back pain, it has received less attention in the cervical spine. Biomechanically, the cervical (neck) and lumbar (lower back) regions of the spine differ in function. Lumbar discs resist a greater burden of body weight, whereas cervical discs are adapted for mobility to aid flexible head orientation. Despite these key differences, disc injury and degeneration …

Diffuse Radiation Controls On Southern Pine Forest Ecosystem Functioning, Jeremy Forsythe

All Dissertations

Diffuse solar radiation, sunlight scattered by atmospheric aerosols and/or clouds, enhances plant photosynthesis through the diffuse fertilization effect (DFE), increasing ecosystem gross primary productivity (GPP) per unit of incoming radiation. Despite this known effect, pine forests of the southeastern United States remain comparatively understudied in the diffuse light literature. This is a critical knowledge gap, as the southeastern United States sequesters more carbon than any other region of the conterminous country (approximately 176 ± 26 Tg C yr⁻¹, or roughly 56% of national forest net carbon exchange), and the region experiences some of the highest biogenic aerosol loads in North …

Neurobiological Mechanisms Of Attention In Adolescents, Virginia Clark

All Dissertations

Adolescence is a transformative developmental period characterized by profound biological, neurological, and behavioral changes. This dissertation investigates the neurobiological underpinnings of attention in adolescents, emphasizing how internal mechanisms influence and individually shape cognitive development through the endosystem. Rooted in the intersection of human development, learning sciences, and cognitive neuroscience, this work argues for a more integrated understanding of attention as a fundamental cognitive function for learning, one that is behaviorally seen but also biologically and neurologically driven. While developmental science has often emphasized external influences such as family, culture, and environment, this work centers on the adolescent’s internal biological systems …

Too Cruel For School: How Parental Rights Doctrine Can Help Protect Against Book Bans, Tessa K. Wild

William & Mary Law Review

This Note argues that parents’ rights protections are crucial to protecting against broad censorship in public schools, and that if states want to effectively regulate book removals, they should preemptively adopt laws similar to Minnesota’s section 134.51.

[...]

Part I of this Note will provide background information about book removals as a freedom of speech issue, as well as a history of how parents’ rights rhetoric is tied to book-removal issues. Part II will address both the history and legal standards of parents’ rights protections. Finally, Part III, using Minnesota and Utah as case studies, will apply parents’ rights law …

Mechanism Of Formation Of Guanine-Guanine Crosslinks As Products Of One-Electron Oxidation Of 1-Methylguanosine In Acidic Medium, Ibrahim Braimah Mr

Electronic Theses and Dissertations

Reactive oxygen species (ROS) from normal metabolism and environmental exposure may cause oxidative DNA damage. Guanine (G) is the most oxidizable nucleobase. One-electron oxidation (OEO) of G in produces guanine radical cation (G•⁺), which deprotonates to form guanyl radical G(-H)•.This radical exists in two tautomeric forms: G(N1-H)• and G(N2-H)•. Dimerization of guanyl radical yields G-G cross-links (D1/D2); a tautomeric form for dimer formation remains elusive. This study presents the first characterization of G• dimerization products from the OEO of 1-MeGuo in acidic medium. Photolysis at 470 nm in the presence of S₂O₈²⁻ and Ru(II)(bpy)₃²⁺ generates two major stereoisomers (D1AW* and …

Examining Professional Self-Doubt And Professional Quality Of Life Among Licensed Professional Counselors In Texas, Celia A. Ramos

Theses and Dissertations

Licensed Professional Counselors (LPCs) in Texas frequently navigate emotionally demanding work, including high caseloads, complex client needs, and sustained exposure to client distress. Over time, these professional demands can contribute to stress, emotional fatigue, and job strain, increasing vulnerability to burnout and reducing professional quality of life (Bardhoshi & Um, 2021; Maor & Hemi, 2021; McCarthy et al., 2010; Thompson et al., 2014). This quantitative research study examined the professional quality of life of LPCs in Texas using the Professional Quality of Life Scale (ProQOL) based on gender, ethnicity, age, licensure type, years of experience, does work setting induce compassion …