Serotonin 7 Receptor Modulation On Measures Of Working Memory And Anxiety, Antonio Gutierrez

Electronic Theses, Projects, and Dissertations

Serotonin (5-HT) function is critical in the regulation and homeostasis of several neural systems. Alterations in 5-HT levels can directly impact the presence of neuropsychiatric disorders such as schizophrenia. With a wide range of 5-HT receptors, the potential impact each of these modulators have on behavior is important to better understand. The 5-HT7 receptor is the most recently identified 5-HT receptor. 5-HT7 receptors can be found in the thalamus, hypothalamus, and several areas of the hippocampus. Modulation of these receptors impact circadian rhythms, hormonal regulation and memory function. Previous research has that 5-HT7 antagonist compounds lead to conflicting results, highlighting …

Interrupting Intergenerational Trauma, Teresa Iribe-Arroyo, Demiana Adel Shenouda

Electronic Theses, Projects, and Dissertations

Adverse childhood experiences (ACEs) are traumatic events that occur during childhood, the ages of 0 and 17. Many individuals may have experienced ACEs without fully recognizing how these early experiences continue to affect their daily lives. These inhibitors can include mental health struggles, physical health problems, academic and behavioral functioning. In contrast, Positive Childhood Experiences (PCEs) can serve as protective factors, helping to buffer against some of the negative outcomes associated with childhood trauma. This proposed study seeks to better understand how both ACEs and PCEs shape individuals into adulthood, particularly in their roles as parents.

This proposed research would …

Raising Resilient Children: Parent Video Guide To Support Children’S Emotional Development, Perla F. Nunez-Chavez

Electronic Theses, Projects, and Dissertations

Social-emotional learning (SEL) in early childhood plays a critical role in

children’s ability to recognize emotions, regulate behavior, build relationships,

and succeed in academic settings. During the preschool years (ages 3–5),

children experience rapid emotional development and rely heavily on parents for

co-regulation, emotional modeling, and guidance. Research consistently shows

that when parents engage in emotion coaching practices, such as labeling

feelings, validating emotions, and modeling regulation strategies, children

demonstrate stronger emotional competence and improved developmental

outcomes. However, despite strong evidence supporting parent involvement in

SEL, many existing interventions are delivered through structured, in-person

programs that are often inaccessible to …

Access, Equity, And Achievement: The Impact Of Student Support Programs On First-Generation College Students Through Their Lived Experiences, Veronica Carrero

Electronic Theses, Projects, and Dissertations

First-generation college students often enter higher education while confronting significant systemic inequalities that limit their academic preparedness, confidence, and sense of belonging. These challenges deeply intertwined and often overlooked intensify gaps, the complexity of their college process, and underscore the urgent need for support structures that nurture both cognitive development and socio-emotional well-being. This qualitative, exploratory, phenomenological study examines the lived experiences of ten first-generation college students enrolled across California State Universities (CSU), focusing on how access and equity initiatives shape their academic journeys.  Student Support Programs such as the Educational Opportunity Program (EOP), TRIO Student Support Services (SSS), and …

Tips For Health Care Practitioners: A Guide For Adolescent Obesity, Regina Santana

Electronic Theses, Projects, and Dissertations

Adolescent obesity continues to be a significant public health concern that is associated with long term physical consequences. The purpose of this project was to develop an evidence based, user friendly guidebook that supports healthcare professionals in the education of adolescents with obesity and their families. A structured literature review development process was used to inform the current development of the guidebook. The guidebook includes components of obesity management such as nutrition and physical activity recommendations. The validity of the content was established through the evaluation of five healthcare professionals that include registered dietitians and licensed therapists. The guidebook was …

Effectiveness Of Independent Living Programs On Preparing Transition-Age Foster Youth For Higher Education And Employment., Naomi Cailipan, Jasmine Nevarez, Emily Matias

Electronic Theses, Projects, and Dissertations

Transition-age foster youth face significant barriers to higher education and stable employment, increasing their risk of housing instability, unemployment, and long-term economic hardship. Independent living programs (ILPs) aim to support the youth develop life skills and connect them to resources that prepare them for a successful transition into adulthood, however, there is limited research that explores the youth’s perspective on the effectiveness of ILPs. This study seeks to provide insight by interviewing current and former foster youth who participated in an ILP by conducting combined research, integrating both quantitative and qualitative approaches. Quantitative data will be collected through a Likert-scale …

Investigating Fentanyl-Xylazine Interactions: Implications For Opioid-Induced Hyperalgesia And Affective Dysregulation In Rats, Alejandra R. Lujan

Electronic Theses, Projects, and Dissertations

The growing prevalence of fentanyl adulterated with xylazine presents a major public health concern, yet the behavioral and physiological effects of this combination remain poorly characterized. This study examined the effects of acute fentanyl administration, alone and in combination with xylazine, on opioid-induced hyperalgesia, affective behavior, and mortality in male and female Sprague-Dawley rats (n=80). Rats received four fentanyl injections (60 µg/kg) administered at 15-minute intervals, with or without xylazine (0, 0.1, 0.333, or 1.0 mg/kg), as well as a saline control condition. Pain sensitivity was assessed using a hot plate assay at 6.5, 12, 24, and 48 hours post-injection. …

Easy Travel-Friendly Snack Recipes For College Students To Support Mental Well-Being, Lidia Vides

Electronic Theses, Projects, and Dissertations

College is a pivotal period in life of a young adult, marked by newfound independence, increased responsibilities, heightened academic pressure, and significant changes in daily routine. While this transition can often be exciting for a young adult, it also presents many different challenges. As a result, many students experience increased levels of stress, anxiety, and depression. Nutrition plays a powerful yet often overlooked role in supporting mental and physical health. Current research studies show that a balanced diet rich in whole food ingredients can help regulate mood and promote emotional well-being through multiple biological pathways. However, despite this knowledge, convenient, …

Lgtbq+ Foster Youth Aging Out Of The Child Welfare System, Anna M. Gutierrez Chavez

Electronic Theses, Projects, and Dissertations

ABSTRACT

On the average time frame, former foster youth were reported homeless between 2012 and 2017. Equally important, is that nearly 39% of homeless youth identify as LGTBQ+.  This research will discuss disproportionality and disparities among youth who struggle with homelessness in the LGTBQ+ population. Research suggests that youth aging out of foster care are more likely to become homeless. Studies found that LGBTQ+ youth being discharged from care did not receive adequate support and guidance from the child welfare system to help them transition into adulthood, which may have led to homelessness.  This study will examine what services and …

Healing Beyond Bars: Integrated And Sustainable Recovery Models For Post-Incarcerated Women, Patricia A. Nunez, Jonathan Solomon

Electronic Theses, Projects, and Dissertations

Substance Use Disorders (SUDs) significantly impact the re-entry process for formerly incarcerated individuals, particularly Latina/x women, who face unique cultural, social, and economic challenges in accessing effective treatment. The purpose of this study is to explore the effectiveness of substance use disorder treatment programs in support of successful reentry outcomes for Latina/x women post-incarceration. Previous research on SUD treatment for this population remains limited despite growing awareness of the need for gender-responsive and culturally informed interventions. Qualitative research with an exploratory design within an interpretive research paradigm will be utilized to investigate the lived experiences of Latina/x women who have …

Barriers To Healthcare In Lgbtq+ Baby Boomers, Kellie Jones, Alexandra Lomeli, Bryant Vargas

Electronic Theses, Projects, and Dissertations

LGBTQ+ Baby Boomers have experienced decades of discrimination, societal suppression, and exclusion from equitable healthcare. Despite advancement in recent years, healthcare disparities persist, and past experiences of discrimination may contribute to present-day barriers in accessing quality care. Existing research often neglects the intersectionality of aging, sexual orientation, and identity, leaving a gap in understanding the long-term effects of historical trauma on healthcare access for this population.

This quantitative study seeks to answer the question: How does the historical trauma experienced by the LGBTQ+ Baby Boomer population impact the healthcare barriers they face? This study proposes to examine the relationship of …

Mental Health Stigma And Barriers Among The Latino Community, Noemi Toraya

Electronic Theses, Projects, and Dissertations

Being faced with a lack of awareness of mental health in the Latino community has brought much attention to the reasons why Latinos lack treatment or choose not to get treated. In Latino culture, mental health is a construct of society, a label applied to justify not being able to function, work, or be present. For many Latinos who experience mental health problems, getting treatment is critical. However, there are several obstacles to overcome, one of which is the stigma associated with mental health and how it is viewed in the Latino community. In Latino communities, stigma sometimes involves associating …

Learning A Second Language In A Second Language: Bi/Multilingual Students’ Experiences In Stem, Lara L. Spence

Electronic Theses, Projects, and Dissertations

Drawing on qualitative interview data from undergraduate students at a public university in California, this thesis conducts a Critical Discourse Analysis (CDA) of the experiences of bilingual and multilingual STEM students as they navigate language barriers in higher education. Specifically, it examines how disciplinary sublanguage, defined as the specialized vocabulary and communication practices unique to an academic field of study, and dominant language ideologies (e.g., monoglossic ideology, the English-only movement, etc.) gatekeep students’ access to knowledge, participation, and academic success. To do so, this thesis employs Fairclough’s three-dimensional model of CDA to connect individual experiences with broader institutional and societal …

Can Carpobrotus Edulis Cause Significant Changes To The Soil Microbiome?, Samantha J. Cowan

Electronic Theses, Projects, and Dissertations

Invasive species cause significant damage to ecosystem biodiversity and can cost billions of dollars to restore native species (Van der Wal et al, 2008; Diagne et al., 2021).  In certain instances, even if the invasive species are removed, they can leave legacy effects on the environment that make restoration more challenging (Conser and Connor, 2008; Elgersma et al., 2011). Carpobrotus edulis is an invasive species of plant that is known to cause changes to its environment such as affecting the soil nitrogen cycle and the pH, potentially leading to persistent changes in the soil microbiome and causing native species to …

Impact Of Social Worker Bias On African American Fathers With Open Children Family Services Cases, Jenna Espinosa, Cecil Perry, Jasmine Alvarado, Jennifer Garcia, Lacrietia Grate-Dixson

Electronic Theses, Projects, and Dissertations

Systemic barriers and biases within institutions and policies affect how African American fathers engage with Children and Family Services (CFS). According to research, social worker bias, whether overt or covert, can influence case decision-making, affecting fathers' access to resources and overall involvement in their children’s lives. This study aims to quantitatively assess the impact of social worker bias on African American fathers' engagement by evaluating service completion rates at the .21e hearing. A quantitative research design will be utilized by implementing a validated survey to measure social worker bias and case file reviews to assess service completion. Statistical analyses, including …

Glucagon-Like Peptide-1ra As A Public Health Interventions, Briana Sepeda

Electronic Theses, Projects, and Dissertations

Glucagon-like peptide receptor agonist (GLP-1RA) medications have become a prominent topic of interest both in clinical medicine and broader societal discussions. Although the medication are relatively new and expensive, ongoing research continues to explore pharmacologic modifications aimed at improving therapeutic effectiveness and prolonged drug half-life. GLP-1RAs have gained significant traction due to their ability to lower glycosylated hemoglobin (A1c) and blood glucose levels in individuals who have been diagnosed with type 2 diabetes (T2D). In addition to glycemic control, evidence suggests its associations with appetite suppression, weight loss, reducing cardiovascular disease, improved renal dysfunction, neuroprotective effects related to neurodegenerative disease …

Investigation Into The Effects Of Moderate-Dose Radiation On Ligament Biomechanics, Andrew Landefeld

All Theses

Recent advances in arthritis treatment pin ionizing X-ray radiation as a useful tool in reducing joint pain and immune response. However, due to a lack of fundamental research in the effects of low-dose ionizing radiation on tendon and ligament biomechanics, the safety of these studies is rather unknown. While most related studies investigated cellular response to low dose treatment, surrounding tissue physiology is left out of the picture. Additionally, moderate range doses of irradiation are rarely studied, as most uses of radiation on tendons and ligaments are for sterilization of cadaver tendons for allografts. This study provides a preliminary investigation …

Hidden Workload In Emergency Medicine: Examining The Role Of Outside-Of-Shift Duties In Emergency Physician Fatigue, Sarah Meyer

All Theses

Emergency physicians (EPs) face high rates of burnout. In addition to well-known stressors, such as fatiguing shift work schedules and intense emotional and cognitive demands faced during clinical shifts, many EPs must also attend to certain outside-of-shift duties (OSDs)–extra-clinical role responsibilities that are expected but not always formally tracked or compensated. These duties often occur during times when EPs are expected to rest and recover from shift work. Despite concerns surrounding burnout in emergency medicine and beliefs among EPs that OSDs contribute to burnout, the effects of OSDs have rarely been studied. Using daily and weekly surveys across 28 days, …

Confronting The Darkness: Nightmare Distress, Fear, And Avoidance Through The Lens Of Courage, Casidee Gonzales

All Theses

Nightmares are an infamous phenomenon where subjective meaning and objective implications meet. This thesis examined nightmare distress’ impact on fear of sleep and nightmare processing avoidance, a novel construct measured with a pilot survey; it also investigated the moderating roles of courage and neuroticism, with PTSD included as a covariate. The research was rooted in the dual-process model of courage and a phenomenology to assess approach and avoidance through goals and risks.

Participants were primarily recruited through Clemson’s SONA system, were mainly White, women, and young adults (N = 351); measures were administered via Qualtrics. Four hypotheses were tested, …

Quantifying Macrophyte Ecosystem Services And Improving Environmental Nonprofit Messaging, Peyton R. Hughey

All Theses

Environmental nonprofits are essential to the management and restoration of our natural spaces. They are also tasked with engaging the public via outreach, education, and advocacy. As natural spaces are degraded, the ability of environmental nonprofits to deliver on their missions will become increasingly important. This study aimed to improve two approaches to environmental nonprofits’ missions: ecological restoration and social media communication.

Environmental nonprofits operate with limited resources, and ecological restoration can be an exhaustive task; therefore, we explore functional restoration as a tool. In this study, we focus on the use of functional, trait-based restoration to restore ecological function …

Mining The Usda Snap Bean Association Panel For Resilience: Genetic Dissection Of Heat And Disease Tolerance In Snap Bean, Atiya F. Khan

All Theses

Snap bean (Phaseolus vulgaris L.) is an economically and nutritionally important vegetable crop whose production is increasingly threatened by rising temperatures and emerging bacterial diseases, particularly in the southeastern United States. Heat stress during reproductive development can significantly reduce yield, while newly emerging pathogens such as Pseudomonas capsici present additional risks to crop productivity. This study leveraged the USDA Snap Bean Association Panel (SnAP) to investigate the genetic basis of heat tolerance and disease resistance and to identify germplasm and genomic regions useful for breeding resilient cultivars.

To evaluate heat tolerance, a subset of the SnAP panel was …

Identity, Party, And Politics: A Discourse Analysis Of Democratic Elites In Pod Save America, Geneva Lei P. Luteria

All Theses

The rise of popular podcasts has shaped public discourse and influenced millions worldwide on how they ought to think, imagine, and act about controversial subjects. Podcasts create an avenue for stories about power and technology to co-create a narrative that viewers buy into. This thesis analyzes one of these essential podcasts, Pod Save America, in how Democratic elite guests approach identity politics, a phenomenon best described as advocacy based on one position’s in society. I begin the thesis by considering the differences in scholarly interpretation of how identity politics functions conceptually and practically. Then, I integrate ideas about how …

The Impact Of Dipeptides On Product Quality In Chinese Hamster Ovary Cells, Louise C. Herman

All Theses

Biopharmaceuticals are medicines produced in cells which are used to treat diseases such as cancer. Monoclonal antibodies (mAbs) represent the majority of approved biotherapeutics. MAbs are mostly produce using Chinese hamster ovary (CHO) cells. CHO cells are favored for resiliency, scalability, and established safety, and are considered the “workhorse” organism for biopharmaceuticals.  Amino acids are a key component of cell culture media, however several amino acids have solubility limits, such as cysteine, cystine, and tyrosine.  At neutral pH, these amino acids are poorly soluble.  However, dipeptides, such as N,N'-di-L-Alanyl-L-Cystine (ACCA) have been reported to increase cysteine and cystine availability. Further, …

How Mindfulness Influences The Frequency Of Flow In Collegiate Athletes, Kelly Torres

All Theses

Flow is defined as a state of optimal experience characterized by deep focus and total absorption that has been consistently linked to enhanced performance (Csikszentmihalyi, 1990; Jackson and Csikszentmihalyi, 1999). Mindfulness, defined as present-moment awareness with acceptance and nonjudgement, has been widely used in sport psychology interventions to improve both performance and well-being (Harris et al., 2023; Kabat-Zinn, 2015; Reive, 2019). However, less is known about how and why mindfulness contributes to performance outcomes and what role flow plays. This study examined the relationship between trait mindfulness and dispositional flow among Clemson University collegiate athletes (N=144), while exploring …

Exercise-Induced Muscle Damage As A Model For Exploring The Effects Of Pain On Gait, Sydney Savage

All Theses

Persistent gait asymmetry following anterior cruciate ligament reconstruction (ACLR) is a recognized contributor to post-traumatic knee osteoarthritis, yet the independent role of pain in driving altered movement patterns remains poorly understood due to confounding factors inherent to clinical populations. This study used exercise-induced muscle damage (EIMD) as a controlled experimental model to isolate the effects of musculoskeletal pain on gait, independent of kinesiophobia, structural damage, and proprioceptive disruption. Eighteen healthy adults underwent unilateral eccentric calf-raise protocols to induce delayed onset muscle soreness (DOMS), with gait assessed at baseline, 48 hours, and 168 hours post-exercise using bilateral inertial measurement units. Outcomes …

Portrayals Of Miscarriage In Film And Television: A Qualitative Analysis, Geovana Leonetti Saraiva

All Theses

Entertainment media may serve as a primary source through which individuals learn about miscarriage; however, little research has examined how miscarriage is portrayed in film and television. This study addresses this gap by conducting a textual analysis of five films and five television shows using a constructivist grounded theory approach. Guided by the model of stigma communication (MSC), communication privacy management theory (CPM), and social support frameworks, the analysis explores how miscarriage is represented in entertainment media.

Findings indicate that the analyzed content frequently includes stigma-related cues—such as marks, labels, responsibility, and peril—that may contribute to the formation and reinforcement …

Design And Development Of A Perfusable Hydrogel Platform With Bioprinted Human-Endothelialized Microvascular Channels, Calvin A. Chernyatinskiy

All Theses

We developed an integrated bioprinting and perfusion platform to generate vascularized hydrogel constructs that support perfusable microchannel networks. Multiple hydrogel formulations, sacrificial ink systems, device geometries, and perfusion conditions were systematically evaluated to optimize print fidelity, mechanical stability, and cellular compatibility. Internally gelling alginate–calcium carbonate hydrogels were identified as a robust matrix, providing tunable gelation kinetics and structural stability during embedded printing. In parallel, Pluronic F-127 fugitive ink enabled reliable fabrication of continuous hollow channels due to its shear-thinning behavior and efficient post-print removal.

The finalized platform integrates stereolithographically fabricated perfusion chambers with extrusion-based bioprinting to produce three-dimensional, perfusable vascular …

Biology, Ecology And Control Of Eye Gnats In An Open Pine Ecosystem, Leela Hospach

All Theses

Eye gnats of the genus Liohippelates are bothersome flies of the family Chloropidae. They breed in moist, disturbed, sandy soils that contain organic matter, and have been implicated as vectors of conjunctivitis, bovine mastitis, and yaws. We conducted research into some basic biological and ecological characteristics. Using wild-caught gnats in a temperature-controlled incubator, we found that their activity peaks between 27°C and 41°C. Trapping at different heights above the forest floor in an open-pine savannah, we captured most gnats at 7.5 m off the ground. This may have to do with the attractiveness of the rotten egg lures we used, …

Characterizing The Molecular Response Of Embryonic Zebra Finch To Acute Sound Playback, Saidat O. Adeniran-Obey Miss

All Theses

Auditory stimuli are important cues that influence developmental plasticity in animals and are important for development and adaptation to an ever-changing environment. In the zebra finch (Taeniopygia guttata), there is evidence of adaptive developmental reprogramming in response to a prenatal ‘heat call’. Embryos exposed to this heat call exhibit changes in growth rate post-hatch, increased heat resistance, and enhanced reproductive success at maturity. However, it has long been assumed that embryonic zebra finches cannot respond to sound due to the immaturity of their auditory system. These findings raise the critical question of whether late-stage zebra finch embryos can, …

Comparative Biomechanics: Blattodea Antennal Morphology And Physiology, Lucas W. Marsh

All Theses

Equipped with muscle-free antennae, many insects can twist and bend their antennae on demand. We hypothesized that hemolymph circulating through the antennae provides pressure that facilitates twisting and bending and provides a feedback control channel for tactile sensing in insects. To test this hypothesis, we conducted a thorough morphological and physiological analysis of antennae in three Clades of Blattodea. We studied morphology by evaluating the distinguishable features of the body and antenna, as well as the internal structure of the antennal lumen. Then, in a series of experiments on live cockroaches, we measured blood pressure along the antenna. This was …