Digital Commons Network^™

Comparative Analysis Of Circadian Rhythms In Humans And Other Mammals, Aashni Atkinson

Harriet L Wilkes Honors College Theses 2020 - Present

Circadian rhythms are biological process that regulate physiological functions on a twenty-four-hour cycle and are conserved across mammalian species. Environmental cues such as light, and behavioral patterns such as sleep schedules and social obligations, play a key role in maintain circadian alignment. This thesis examines how molecular, environmental, behavioral, and medical factors influence circadian regulation and contribute to differences between humans and other mammals. While the core molecular clocks, which are driven by transcription-translation feedback loops, remain consistent across species, humans’ circadian rhythms are frequently disrupted. In humans, technology and irregular routines lead to circadian misalignment. This disruption is associated …

Corporate Personhood And The Scope Of Constitutional Rights, Jadyn Cooper

Harriet L Wilkes Honors College Theses 2020 - Present

In 2010, the Supreme Court, in Citizens United v. FEC, held that corporations have a First Amendment right to freedom of speech. Soon after, privately held corporations were effectively granted the First Amendment right to exercise religion, in Burwell v Hobby Lobby. Should corporations have these rights, or are rights reserved for “persons”? I argue that for-profit corporations, as artificial entities, lack the capacities for personhood and moral agency, including the capacity to express speech or exercise religion, without the use of a human agent. Since corporations are not moral agents, they don’t possess rights inherently and shouldn’t be granted …

Design & Create A Device That Tests Amphiphilic Anti-Biofouling Coatings, Monroe Macuch, Casey Collins, Parker Mcgregor, Aidan Madura, Rosario Apa

Mechanical Engineering Capstone Design Projects

Marine biofouling, defined as the unwanted accumulation of biological organisms on submerged surfaces, leads to increased hydrodynamic drag, fuel consumption, corrosion, and maintenance costs for marine vessels and infrastructure. Amphiphilic antifouling coatings have emerged as a promising environmentally friendly alternative to traditional coatings due to their ability to resist both hydrophobic and hydrophilic fouling organisms. Despite their potential, a key limitation in advancing these coatings is the lack of a standardized, controlled, and repeatable method for evaluating performance under dynamic flow conditions representative of real marine environments. This project focused on the design, fabrication, and validation of a laboratoryscale device …

Neural Mechanisms Underlying Jung’S Active Imagination: A Review And Hypothesis, Charles R. Fox

Journal of Conscious Evolution

Active imagination is a key technique of Jungian analysis. Despite its centrality, and its potential importance beyond Jungian psychology to the area of systems neuroscience, psychology, and consciousness studies, there are no known neurological mechanisms underlying this psychological phenomenon. There is a history of using the types of mental imagery used in active imagination to explore consciousness. The development and use of active imagination is briefly reviewed, and a case is developed that the neurology underlying active imagination would be fruitfully explored by considering it a special case of mystical experience. Active imagination primarily uses the right hemisphere processing of …

Automated Analysis Of Radiation Oncology Incident Reports Using Large Language Models, Nathan A. Dobranski

LSU Master's Theses

Patient safety incident reporting in radiation oncology requires expert analysis that is time-intensive and subject to variability. This thesis presents the development and technical validation of a locally deployed large language model (LLM) system for automated incident report analysis across multiple cancer centers. The system was designed for automated summarization and taxonomy assignment of Radiation Oncology Incident Learning System (RO-ILS) reports, operating entirely on local infrastructure to preserve patient privacy. A two-round, multi-rater evaluation methodology was employed, incorporating 600 total expert evaluations from two academic cancer centers. Round 1 established baseline performance using Mistral 7B and Mixtral 8x7B models with …

Does Climate Disclosure Work To Reduce Greenhouse Gas Emissions? Emerging Evidence Suggests Cautious Optimism., Cynthia A. Williams

Articles by Maurer Faculty

The purpose of this Article is to bring some of the emerging empirical literature evaluating the effects of required greenhouse gas (GHG) disclosure to bear on discussions of disclosure as a mechanism to address climate change. Since disclosure has become such a significant part of global efforts to address climate change, whether it has the effects in fact that are attributed to it in theory is properly subject to interrogation.   In this Article, several interrelated questions will be discussed. First, what does the empirical evidence show about the effects of required (GHG) disclosures on emissions? What mechanisms are engaged in …

Recommendations Made And Accepted By A Telehealth-Enabled Antimicrobial Stewardship Program Implemented At Rural Veterans Affairs Medical Centers, Taissa A Bej, Jason P Burnham, Joshua D. Nordman, Et Al.

2020-Current year OA Pubs

BACKGROUND: To support Antimicrobial Stewardship programs (ASPs) as well as the clinical care of patients with infections, we disseminated and implemented a Videoconference Antimicrobial Stewardship Team (VAST) to connect multidisciplinary teams from rural Veterans Affairs (VA) medical centers with geographically distant ID experts. Here, we describe the clinical syndromes discussed and the response to recommendations made during VAST sessions.

METHODS: Between September 2021 to February 2024, eight ID consultants established VASTs with ten rural VAMCs, holding regularly scheduled videoconference sessions to discuss clinical cases and provide recommendations. Data were collected on patient demographics, clinical syndromes, and recommendations. Acceptance of recommendations …

Syrah: A Pipeline To Maximize Spatial Transcriptomics Data Output, Carolyn Brewster, Frederick G Mann, Blair Benham-Pyle, Alejandro Sánchez Alvarado

Faculty, Staff and Students Publications

Spatial analysis of gene expression patterns has been a key technique for revealing the potential functions of genes. Traditionally, these analyses conducted using in-situ hybridizations and other labor-intensive protocols were constrained to examining only a few candidate genes per sample. However, the advent of spatial transcriptomic techniques like Slide-seqV2 has transformed this field, enabling massively parallel exploration of gene expression patterns within their tissue contexts by pairing spatial locations with RNA sequencing. Despite its potential, Slide-seqV2 datasets often produce fewer usable reads than expected. We have identified that a significant source of errors in the technology stems from the chemical …

Kajian Dari Perspektlf Hak-Hak Perempuan Tentang Perkawinan Campuran, Mutiara Hikmah

Jurnal Hukum & Pembangunan

Abstract

Effect Of Ta2O5 On The Surface Characteristics And Corrosion Behaviour Of Epd Hydroxyapatite/Chitosan Coating On A Ti6al7nb Alloy, Yasir M. Abdulsahib, Makarim H. Abdulkareem, Ali M. Mustafa

Engineering and Technology Journal

The Ti6Al7Nb alloy is widely used as an orthopedic implant in biomedical applications. Despite its excellent corrosion resistance and mechanical properties, metallic wear particles and metal ion release occur over long spans. In order to improve the surface properties of the Ti alloy and develop its clinical use, electrophoretic deposition has been applied to enhance the surface characteristics of the Ti alloy. In this study, a hydroxyapatite-chitosan nanocomposite coating was applied on the Ti6Al7Nb implant alloy surface with varying tantalum oxide contents of 0, 10, 30, and 50 wt.% at a direct current of 60 V for 6 minutes. Hydroxyapatite …

Usaha Negara Dalam Menghadapi Kerusakan Lingkungan Hidup Yang Terjadi Di Luar Yurisdiksi Nasional, Leonardo Bernard

Jurnal Hukum & Pembangunan

Abstract

Dampak Berlakunya Trips Agreemen Terhadap Pelaksanaan Konvensi Keanekaragaman Hayati, F.X. Adji Samekto

Jurnal Hukum & Pembangunan

Abstract

Proposed Evidence-Based Practice Guidelines For Using Esmolol To Blunt The Sympathetic Stress Response To Laryngoscopy And Intubation, Maya Kurdi

Doctor of Nursing Practice Scholarly Projects

Direct laryngoscopy (DL) and endotracheal intubation (ETI) are standard procedures performed during general anesthetic induction, which provoke a sympathetic stress response that can result in intraoperative hemodynamic instability. Traditional agents like lidocaine and fentanyl, commonly used to mitigate the stress response, have limitations and can lead to adverse effects. Recent literature suggests that esmolol, an ultra-short-acting, cardio-selective beta-1 adrenergic receptor antagonist, may be an effective alternative due to its rapid onset, short duration, and minimal side effects. This final scholarly project (FSP) aims to develop evidence-based practice guidelines for using esmolol as an adjunctive induction agent. A systematic literature review …

Two Sides Of The Same Cycle: Understanding The Experiences Of Domestic Violence Survivors And Perpetrators, Avery M. Blevins

Honors Theses

Domestic violence has been a prevalent concern throughout society for many years but has recently begun to cumulate awareness from policymakers, people in the community, and individuals in service professions. There have been various changes made to the way that we define and understand domestic violence which has further led to the need to explore and educate on this concern. This paper aims to understand the experiences of both survivors and perpetrators that led to such violent circumstances. This creates a more multifaceted understanding of domestic violence and aids in implementing effective resources to both prevent and intervene in violent …

Soma: Exploring Touch As Performance And Performance As Therapy, Erica Pamson

Expressive Therapies Theses

This project investigated the role of touch within a performative context and its potential as a creative intervention within Expressive Arts Therapy. Grounded in phenomenology and intersubjectivity, the study draws on Expressive Arts Therapy (EXAT) and Performance Art frameworks that position meaning as emerging through embodied, co-created experience. Existing literature identifies touch as a primary mode of perception and communication, essential to both physical and emotional well-being, while also noting its increasing absence and regulation within contemporary Western culture. Performance art literature further highlights the body as both medium and site of relational exchange, often dissolving boundaries between performer and …

Institutional Silence And The Governance Of Women College Athletes’ Reproductive Autonomy In The United States, Tarlan Chahardovali, Molly Harry Ph.D., Emily S. Mann Ph.D.

Faculty Publications

This study examines how women college athletes understand their pregnancy-related rights and protections and how institutional communication – or its absence – shapes reproductive autonomy within college sport. Guided by a reproductive justice framework, it conceptualizes pregnancy as a site of reproductive governance shaped by institutional policies, norms, and silences within performance-oriented sport organizations. The analysis draws on semi-structured interviews with 25 women college athletes from various NCAA Division I institutions in the United States, conducted between September 2023 and July 2024 in the post-Dobbs legal context, and uses reflexive thematic analysis to examine athletes’ knowledge of Title IX and …

Fiber Consumption Of Three Lemur Species With Varying Dietary Specializations, Dylan Daniels

Honors Capstones

Fiber is an important macronutrient as a source of energy for maintaining animal health. My research question is what is the fiber content of foods consumed by lemur species with different dietary specializations (Propithecus diadema, Eulemur fuvlus, and Hapalemur griseus) and are there seasonal changes? 172 plant foods were collected in Tsinjoarivo, Madagascar during the resource-abundant and lean season. I analyzed these samples using the neutral detergent fiber method, which simulates digestion and measures insoluble fiber. Knowing how much fiber lemurs consume and how they adapt to seasonal variation in the food supply will allow for restorative actions to be …

Assessing The Risk Of Low Energy Availability In Ncaa Division Iii Female Soccer Players, Emma C. Sturts

Masters Theses/Capstone Projects

Low Energy Availability (LEA) can occur when an athlete’s energy intake is insufficient to meet the physiological demands of training as well as normal physiological functions. Female soccer players may be at an increased risk of developing LEA due to the high exercise energy expenditure paired with decreased energy intake. The purpose of this study is to assess the prevalence of LEA among Division III female soccer players. Division III female soccer players (n = 11) completed the Low Energy Availability in Females Questionnaire (LEAF-Q). 45.5% (n = 5) of the participants were classified as “At Risk” for LEA. Of …

A New Subspecies Of Papilio Indra (Papilionidae) From The West Desert Of Utah, Usa, Wayne H. Whaley, Alexander A. Jason, Todd L. Stout

The Taxonomic Report of the International Lepidoptera Survey

Papilio indra bonnevillensis is a new described subspecies partly based on taxonomic rearrangement of its larval host plant reproductive phenology relative to Wasatch Range nominate P. indra. It is geographically isolated in Utah’s West Desert from populations of ssp. nevadensis to the west and ssp. calcicola to the south. In addition to phenological differences compared to these two subspecies, it merits description based on host Lomatium depauperatum which recently speciated from L. grayi, neither of which is used as host by other subspecies of P. indra. The evolution of new host L. depauperatum is …

Neurodiversity In The Workplace: Organizational Approaches To Supporting Neurodiverse Employees, Madison Vasquez

M.S. in Leadership

Despite growing conversation around neurodiversity in the workplace, many organizations lack clear understanding and structured strategies to support neurodivergent employees. This study examines existing research on how organizations can more effectively support neurodiverse employees across the employee lifecycle. Using a qualitative literature review, this study addresses the research question by examining literature on neurodiversity within workplace contexts. This includes investigating common representations of neurodiversity and reviewing the strengths and challenges of neurodiverse individuals, including those who have autism, ADHD, and other forms of neurodivergence. The study also reviews workplace barriers, support strategies, and organizational outcomes identified across the literature. Key …

The Effect Of Stress Hormones On Memory Formation And Academic Performance, Emma L. Hooks

Senior Honors Theses

With chronic stress becoming increasingly prevalent in academic settings, researchers have identified significant effects on learning and academic performance. Cortisol, a glucocorticoid hormone, is released following the activation of the hypothalamic-pituitary-adrenal (HPA) axis and plays a vital role in the stress response. Although acute increases in cortisol can improve attention and memory, sustained activation of the stress response can impair memory, executive functioning, and academic performance. This thesis draws on neuroscience, psychology, and education research to examine how chronic cortisol exposure affects the hippocampus and prefrontal cortex, and how the effects manifest in learning and academic performance, particularly in developmental …

Commencement 2026 (Program And Video), Illinois Wesleyan University

Commencement Ceremonies

No abstract provided.

Tropomyosin-Related Kinase Receptor Type B Agonism In Geographic Atrophy-The Translational Challenges From Preclinical Data To A First-In-Human Trial, David Brown, Oliver Zeitz, Clare Bailey, Sunir J. Garg, Karl Csaky, James Talks, Sobha Sivaprasad, Peter M. Benz, Rolf Herrmann, Remko A. Bakker, Sebastian Bandholtz, Ankit Mittal, Qihong Huang, Serge Kosobokovs, Gudrun Simons, Andrea Giani, Jochen Huber, Martin Gliem

Wills Eye Hospital Papers

OBJECTIVE: To report results of the first-in-human trial of intravitreal tropomyosin-related kinase receptor type B (TrkB) agonist BI 754132 in participants with geographic atrophy (GA). To discuss BI 754132 clinical data in the context of the preclinical findings and their translation into human data.

DESIGN: An open-label, uncontrolled, nonrandomized phase I trial (NCT04002310) assessing the safety, tolerability, and pharmacokinetics of BI 754132 in participants with GA supported by preclinical data.

PARTICIPANTS: Participants with GA recruited between July 2019 and August 2022 in the United States and UK.

METHODS: Clinical trial comprising a single rising dose (SRD) part (n = 15) …

Comparing The Effectiveness Of Neb Precrtm Repair Mix And Nxgen T4 Dna Ligase For Repairing Degraded Dna For Pcr Forensic Applications, Karolena Zvokel

Honors Theses

This study investigated the comparison between using PreCRTM mix (New England Biolabs) and T4 DNA Ligase (New England Biolabs) to repair degraded forensic whole blood DNA samples for PCR amplification. Degraded DNA presents a significant challenge in forensic STR analysis due to reduced amplification efficiency and allele imbalance. Whole blood samples were extracted, quantified, and artificially degraded using UV exposure. Samples were introduced to multiple treatments, including no damage no repair (NDNR), damage no repair (DNR), PreCRTM repair, T4 DNA ligase treatment, and combined repair approaches. Amplified products were analyzed using capillary electrophoresis, and peak height ratios (PHR) were used …

Employing Zebrafish To Understand Genetic Drivers Of Epilepsy-Related Comorbid Behaviors, Chinwendu Ononuju, Kharma Hall, Olivia Beatty, Scott C. Baraban, Colleen Carpenter-Swanson

Biology Faculty Publications

Children with epilepsy frequently experience a range of significant comorbidities beyond seizures, such as motor dysfunction, cognitive impairment, and neurodevelopmental delays. In some cases, these comorbidities contribute more significantly to overall disease burden than the seizures themselves. To improve quality-of-life (QOL) for these children, treatment options should be selected that control seizures and ameliorate comorbidities. Unfortunately, such therapeutics remain largely elusive. Addressing this issue requires suitable preclinical models. Here we used CRISPR-generated zebrafish with single-gene mutations linked to pediatric epilepsy and applied clinically-relevant behavioral assays to study the effects of these mutations. Using high-throughput locomotion-based assays, we uncovered errors in …

Frailty As A Surgical Vital Sign: A Narrative Review Of Risk Stratification And Outcomes In General Surgery, Ambrose Loc T. Ngo, Matthew Tiojanco, Ian Miller, Linda Nguyen, Uyen Tam Nguyen, Carolyn Duong

Student Publications

Frailty has emerged as a critical determinant of perioperative risk, yet it remains underutilized in routine surgical assessment. As the global population ages, an increasing proportion of patients undergoing general surgery present with diminished physiologic reserve that is not adequately captured by traditional risk stratification tools. This narrative review examines frailty as a multidimensional construct and its role as a prognostic marker in general surgery, with the aim of synthesizing current evidence on its biological basis, evaluating commonly used frailty assessment tools, and examining its impact on postoperative outcomes, including morbidity, mortality, length of stay, and discharge disposition. A comprehensive …

Annona Muricata (Soursop) And Hematopoiesis: Ethnomedicinal Insights, Immunomodulatory Mechanisms, And Translational Challenges, Fatma Matano, Amiya Patra

Peninsula Medical School

Annona muricata (soursop) is a tropical medicinal plant widely used in traditional medicine across Africa, the Caribbean, and parts of South America. While its ethnomedicinal applications span a range of conditions, including infections, inflammation, and anemia-related symptoms, its potential relevance to hematopoiesis has not been systematically examined. This narrative review synthesizes ethnomedicinal knowledge, phytochemical composition, and experimental evidence to explore the biological plausibility by which A. muricata may indirectly influence hematopoietic processes. Bioactive constituents of A. muricata, including flavonoids, polyphenols, and acetogenins, have demonstrated antioxidant, anti-inflammatory, and immunomodulatory properties in preclinical models. These effects are particularly relevant given the established …

Tractor Workflow: A Scalable Nextflow Framework For Local Ancestry-Aware Genome-Wide Association Studies, Nirav N Shah, Taotao Tan, Jessica Honorato-Mauer, Yi-Sian Lin, Adam X Maihofer, Clement C Zai, Pgc-Ptsd Ancestry Working Group, Marcos Santoro, Caroline M Nievergelt, Elizabeth G Atkinson

Faculty, Staff and Students Publications

Motivation: The routine exclusion of admixed individuals from traditional genome-wide association studies (GWAS) due to concerns about spurious associations has limited multi-ancestry genetic discovery. Tractor addresses this issue by incorporating local ancestry into association testing, enabling the identification of ancestry-enriched signals and generating ancestry-specific summary statistics. However, adoption has been constrained by the complexity of prerequisite steps, including phasing and local ancestry inference, which require substantial bioinformatics expertise and introduce key analytical decision points.

Results: We developed a scalable, automated Nextflow workflow that integrates phasing, local ancestry inference, and Tractor association testing into a reproducible end-to-end pipeline. To demonstrate its …

Nuclear Export As A Therapeutic Vulnerability In Zfta-Rela Ependymoma, Siri M Ippagunta, Amir Arabzade, Srinidhi Varadharajan, Erik Emanus, Amanda Bland, Alisha Kardian, Nicholas Laboe, Hua Sun, Tuyu Zheng, Amelia Hancock, Mark Zhai, Emma Caesar, Maxwell Park, Wilda Orisme, Melissa Johnson, Brittany Rodgers, Gregory H Turner, Jeffrey Steinberg, Burgess Freeman, Martine F Roussel, Anang Shelat, Richard Kriwacki, Thomas E Merchant, Benjamin Deneen, Michael D Taylor, Sameer Agnihotri, Shondra Pruett-Miller, Jacob A Steele, Anoop Murthy Kavirayani, David W Ellison, Arzu Onar-Thomas, Giles Robinson, Stephen C Mack, Kelsey C Bertrand

Faculty, Staff and Students Publications

Background: Ependymoma (EPN) is the third most common pediatric brain tumor with no targeted therapies available to patients. In supratentorial ependymoma, the most frequent driver alteration is a gene fusion between ZFTA and RELA (denoted ZR), leads to constitutive localization of ZR in the nucleus. Because ZR is not currently druggable, we tested whether ZR expression leads to aberrant protein interactions that could represent therapeutic vulnerabilities.

Methods: Using CRISPR-Cas9 pooled screening, we identified many novel druggable ZR interacting proteins including XPO1, CARM1, SMARCA4, and CDK1. We focused on the nuclear export protein (XPO1), given the ability of most XPO1 inhibitors …

Evaluating The Suitability Of The Berg Balance Scale For Assessing Balance In Diabetes With And Without Prior Covid-19: A Methods-Validation Study, Garima Kaushik Dr, Sheetal Malhan Dr., Apoorva Tiwari Dr, Vishakha Daga Dr

Journal Of Indian Physician Associates

ABSTRACT

Background: Balance impairment in diabetes mellitus is predominantly driven by somatosensory loss secondary to peripheral neuropathy. The Berg Balance Scale (BBS) is widely used to evaluate functional balance, yet it mainly reflects motor performance and may not adequately represent sensory mechanisms. Following COVID-19, additional concerns regarding deconditioning have emerged, but interpretation depends on the measurement tool employed.

Objective: To examine the construct behavior and suitability of the BBS for assessing balance in individuals with diabetes with and without prior COVID-19 infection, and to determine whether the scale reflects known determinants of diabetic imbalance.

Methods: A cross-sectional analysis was conducted …