Digital Commons Network^™

Mental Health Comorbidities And Ibd Outcomes On Anti-Tnf Therapy, Jashanveer S. Johal, Mahmoud Al-Bataineh, Archana Salek, Bianca Patel, Om Patel, Jason Hyman, Yecheskel Schneider, Abdallah Hussein

Rowan-Virtua Research Day

Background: Depression and anxiety are prevalent in inflammatory bowel disease (IBD) and may adversely affect biologic therapy outcomes. We evaluated the impact of comorbid mood disorders on clinical outcomes among IBD patients treated with anti-TNF agents.

Methods: Using a global de-identified electronic health record network, adults with Crohn's disease or ulcerative colitis initiating an anti-TNF agent between 2018–2023 were identified. Cohort 1 included patients with a documented mood disorder (depression and/or anxiety) at or prior to anti-TNF initiation; Cohort 2 included those without mood disorders. Propensity score matching (1:1) on demographics and comorbidities yielded 9,605 patients per cohort. Primary outcomes …

Risk Of Colorectal And Gastrointestinal Neoplasia In Inflammatory Bowel Disease Treated With Adalimumab Versus Vedolizumab And Ustekinumab: A 5-Year Multicenter Retrospective Cohort Study, Jashanveer S. Johal, Archana Salek, Mahmoud Al-Bataineh, Bianca Patel, Abdallah Hussein, Om Patel, Jason Hyman, Yecheskel Schneider

Rowan-Virtua Research Day

Background: Inflammatory bowel disease (IBD) is associated with increased colorectal cancer (CRC) risk, but comparative neoplastic risks across biologic classes remain uncertain. We evaluated 5-year risks of CRC and GI neoplasia in IBD patients treated with adalimumab versus vedolizumab and ustekinumab using real-world data.

Methods: Using the TriNetX Global Collaborative Network, two parallel 5-year propensity score–matched cohort analyses were conducted among adults with Crohn's disease or ulcerative colitis initiating adalimumab, vedolizumab, or ustekinumab between 2018–2024, excluding patients with prior CRC or colectomy. The adalimumab–vedolizumab analysis matched 13,292 patients per cohort; the adalimumab–ustekinumab analysis matched 14,591 per cohort. Primary outcomes were …

Identification Of Genes Regulating The Gli Protein Tra-1 In ​Caenorhabditis Briggsae Through A Genetic Suppressor Screen​, Alexander Glenn Cabrera, Sanese Brown-White, Ronald Ellis

Rowan-Virtua Research Day

BACKGROUND:
Gli proteins are conserved transcription factors that regulate cell fate, proliferation, and patterning. In Caenorhabditis briggsae, the Gli protein TRA-1 functions as the terminal regulator of the sex-determination pathway to control sexual development. These nematodes lack Hedgehog signaling, so TRA-1 is regulated by other factors. The missense mutation tra-1(v48) disrupts TRA-1 activator function, resulting in complete feminization of XX animals, which would otherwise be hermaphrodites.

HYPOTHESIS:
Suppressor screens using tra-1(v48) mutants will identify novel cofactors required for TRA-1–mediated Gli activation and spermatogenesis.

METHODS:
Ethyl methanesulfonate (EMS) mutagenesis was performed on tra-1(v48) strains to induce random mutations. Dominant suppressors were …

Efficacy Of Omalizumab And Exposure Immunotherapy In Reducing Allergic Immunological Response, Joshua James Novello, Michelle Lau, Josephine L. Miner, Mudassir A. Rahmani, Kimran Sandhu, Taha Umar

Rowan-Virtua Research Day

Background: Food allergy negatively impacts numerous children in the United States. Oral immunotherapy (OIT) and biologic therapy (omalizumab) are emerging promising strategies for desensitization. This literature review aims to compare the effectiveness of omalizumab and oral immunotherapy in pediatric populations.

Hypothesis: If the use of omalizumab therapy is used to treat children with food allergies compared to OIT, then there would be higher desensitization, lower post-treatment IgE levels, higher IgG4 levels, and decreased chance of a positive skin prick test.

Methods: PubMed, Embase, and The Lancet databases were searched using PRISMA guidelines to locate peer-reviewed studies evaluating …

Understanding Communication In Green Infrastructure Project Teams In Rochester Ny Region: Coordination, Negotiation, And Constraints, Hayden Berner

Theses

This study explores how communication is perceived and used within multidisciplinary green infrastructure (GI) project teams. As GI continues to grow in the United States, projects increasingly rely on collaboration between professionals from different fields, making communication a critical factor in project success. Using a qualitative research approach, semi-structured interviews were conducted with professionals working on GI projects in the Greater Rochester, New York region. The data were analyzed using an inductive, grounded theory approach to identify key themes related to communication practices, challenges, and outcomes. Results show that communication is not just a tool for sharing information, but a …

Genetic Analysis Of Triplicated Genes Affecting Sex-Specific Skeletal Deficits In Down Syndrome Model Mice, Kourtney Sloan, Kristina M. Piner, Pathum Randunu Nawarathna Kandedura Arachchige, Charles R. Goodlett, Yann Herault, Gayla R. Olbricht, Joseph M. Wallace, Randall J. Roper

Mathematics and Statistics Faculty Research & Creative Works

Down syndrome (DS) is caused by the triplication of human chromosome 21 (Hsa21), resulting in skeletal insufficiency (low bone mineral density) and altered bone development. DS mouse models recapitulate these deficits, including sexual dimorphism in long bone alterations. Historically, Ts65Dn mice provided much of the insight behind DS-related skeletal deficits with ∼100 trisomic orthologous genes, but there are concerns about the genetic fidelity in this model due to the included triplication of genes not homologous to Hsa21. A new DS model, Ts66Yah, subtracted the non-Hsa21 homologous trisomic genes from Ts65Dn but has not been evaluated for long bone deficits. Comparing …

The Longevity Of Dna From Bloodstains And Its Forensic Implications, Nadia Walter

Senior Honors Theses

Human DNA is valuable forensic evidence, helping to solve a wide range of cases. It is often sourced from biological fluids found at a scene such as blood, saliva, semen, and urine. Many different factors can influence the longevity of DNA sourced from bloodstains, including the type of substrate, storage conditions, and weather. The quality of a DNA sample from a bloodstain found at a crime scene may influence its admissibility in court.

Original research was done on a surgical table from the last major battle of the American Civil War, extracting DNA from latent bloodstains. Some full profiles were …

Acquisition Behavior Response: Investigating The Ability Of Leptoglossus Phyllopus To Choose Between A “Good” Versus “Sub-Optimal” Strain Of Caballeronia, Irene L. Pham

2026 Spring Honors Capstones Projects

Leptoglossus phyllopus is a polyphagous pest that primarily feasts on citrus, tomatoes, and legumes. They must form a mutualistic symbiosis with Caballeronia every generation by ingesting the bacterium from their environment. However, not all species of Caballeronia confer the same fitness on the L. phyllopus host, raising the question of whether L. phyllopus possesses a partner choice mechanism that would allow it to distinguish between a good (GAOX1) and a suboptimal (Lep1P3) symbiosis partner. This was examined by conducting a choice experiment in which the two symbionts (GAOX1 vs. Lep1P3) were placed in a plastic box, and the bug’s roaming …

Mass Spectrometry-Based Spatial Imaging Of The Cochlea, Roberto A. Ribas, Qun Tang, Scarlett I. Caffee, Cameron J. Shedlock, Tara R. Hawkinson, Abigail K. Dragich, Borhane E.C. Ziani, Franca Bucco Paolasso, Alyson P. Black, Xin Ma, Harshitha C. Kota, Li Chen, Gregory I. Frolenkov, Derek B. Allison, Matthew S. Gentry, Ramon C. Sun, Craig W. Vander Kooi

Physiology Faculty Publications

Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI) is transforming spatial molecular studies. However, applying MALDI-MSI to small, anatomically complex tissues remains challenging. One such structure is the cochlea, the auditory part of the inner ear that is critical for hearing. To address these challenges, we developed and implemented a streamlined workflow for sample preparation and processing to obtain MALDI-MSI data on mouse cochlea. Sample acquisition was optimized to minimize time and processing steps, allowing use of flash-frozen neonatal mouse heads. This workflow enabled high spatial resolution metabolomic and lipidomic imaging of the sagittally cryosectioned mouse cochlea using N-(1-naphthyl) ethylenediamine dihydrochloride …

Engagement Modeling And Inference For Risk-Aware Path Planning Under Adversarial Uncertainty, Grant Stagg

Theses and Dissertations

This dissertation develops methods for planning safe and efficient trajectories for autonomous vehicles operating in environments containing adversarial and environmental threats with uncertain parameters. The central objective is to quantify and control the risk of adverse events--such as interception or detection--when threat characteristics are imperfectly known. To address this challenge, probabilistic weapon engagement zone (PEZ) models are introduced to estimate the likelihood of violating adversarial engagement constraints under uncertainty in pursuer state and capabilities. Multiple computational strategies are developed for PEZ evaluation, including first-order sensitivity-based approximations, Monte Carlo estimation, and neural-network surrogate models. These approaches enable rapid engagement-probability assessment and …

Largest 2-Regular Subgraphs In Complete S-Partite Graphs, Yiyang Jiang

McKelvey School of Engineering Graduate Student Theses & Dissertations

In this thesis, we focus on the class of complete $S$-partite graphs, for $S$ an undirected graph possibly with self-loops, and address the problem of finding largest $2$-regular subgraphs of these graphs, which can be formulated as an integer linear program. Roughly speaking, a complete $S$-partite graph is obtained by replacing every single node of $S$ with a number of nodes, preserving the edge/non-edge relations of $S$. Our motivation in studying largest $2$-regular subgraphs is rooted in the structural systems theory, particularly in the problem of finding largest subnetworks that can sustain controllability or asymptotic stability of the corresponding subsystems. …

Stability Of Sufentanil Sublingual Microtablets (Dzuveo) In Extreme Cold Weather Conditions: An Experimental Study, David Mcconnell, Hayley Manners, Paul Sutton, Nicola Gawman, Tim Parham, Jonathon Lowe

School of Geography, Earth and Environmental Sciences

Introduction Extreme cold weather environments are challenging for medication storage and delivery, particularly for injectable analgesics vulnerable to freezing and device failure. These risks may compromise pain management in austere or operational settings where temperature control cannot be maintained. Sufentanil sublingual microtablets (sold in the UK as Dzuveo) provide an oral analgesic option with manufacturer-reported sub-zero stability. Evidence describing the effects of sustained extreme cold exposure and repeated freeze–thaw cycling on chemical stability and delivery system function is limited.Methods We conducted a laboratory study assessing the effect of sustained freezing and repeated freeze–thaw exposure on sufentanil sublingual microtablets (30 µg …

Trauma, Memory, And Decision-Making: How Covid-19 Shaped Autobiographical Memories And Risky Decision-Making In Young Adults, Rachel Seo

Student Theses

Autobiographical memory is a critical component of the memory process that guides future behaviors by relying on past personal experiences connected to major public events. This decision-making process is heavily influenced by trauma exposure and post-traumatic stress disorder (PTSD) symptoms, as they may guide individuals to riskier behaviors. The COVID-19 pandemic represents a global traumatic stressor that contributed to shifts in behavioral outcomes post-pandemic. Despite research showing associations between memory accessibility, traumatic symptoms, and decision-making, there is limited research on health-related behaviors and post-pandemic behavioral outcomes in individuals with high trauma exposure specifically from the pandemic. The present study investigates …

Predicting And Decoding Allosteric Binding Sites Using Protein Language Models And Structure-Based Machine Learning: An Energy Landscape-Guided Explainable Ai Framework, Kamila Riedlová, Vít Skrhák, William G. Gatlin, Max Ludwick, Lucas Turano, Marian Novotný, David Hoksza, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

Computational prediction of allosteric binding sites in protein structures remains a persistent challenge, as these regulatory pockets evade detection by both sequence-based and structure-based algorithms. Both computational and physical origins of this predictive asymmetry remain insufficiently understood. In this study, we systematically examine the determinants of binding site predictability using a dual framework that integrates a fine-tuned protein language model and the structure-based method P2Rank as complementary tools probing a diverse data set of 453 human kinases, together with a physics-based interpretability layer derived from energy landscape frustration analysis. Both predictors exhibit a sharp and reproducible dichotomy on protein kinases, …

Sea Turtle Polyphenism, Anson J. Butler, Alessandro G. Galante

Student Work

No abstract provided.

Neurodevelopmental Effects Associated With In Utero Exposure To Bpa, Maximilian A. Nilsen, Grace A. Carlucci, Cody V. Thompson, Berfin Gul

Student Work

No abstract provided.

Seasonal Variation And Size Distribution Of Particulate Matter In The Mississippi Delta: Implications For Source Attribution, Abigail E. Barnett

Honors Theses

This study examines seasonal patterns of particulate matter in the Mississippi Delta using data from PurpleAir sensors, with a focus on particle size distributions across PM₁.₀, PM₂.₅, and PM₁₀. The purpose of this research is to evaluate whether particulate trends in the region reflect signatures consistent with wildfire smoke or are better explained by local environmental and agricultural factors.

Daily average concentrations were analyzed and grouped by season to compare spring and summer conditions. Results show that all particle size fractions increased from spring to summer. However, PM₁₀ concentrations remained consistently higher than PM₂.₅ in both seasons. The PM₂.₅/PM₁₀ ratio …

Quantifying Genetic Diversity In Nematode Feeding Rate, Jacob King

Honors Theses

Understanding how populations persist under changing environmental conditions is a central question in ecology and evolutionary biology. Variation in traits related to resource acquisition may play a key role in determining population survival when resources are limited or fluctuate over time. In this study, I investigated how variation in feeding-related traits influences population persistence using a combination of computational modeling and laboratory experiments. I developed a stochastic, individual-based consumer–resource model to simulate population dynamics across varying levels of trait variance and resource regimes. Across 60,000 simulated populations, increased trait variation consistently reduced extinction risk and extended persistence time, although the …

The Effects Of Mississippi Mandated Testing On Students And Teachers, Christopher I. Goss

Honors Theses

This thesis concerns the direct impacts of the Mississippi mandated standardized testing, used for graduation, on Mississippi public school teachers and students. To collect appropriate data, I used the Qualtrics survey platform to fit in the parameters needed for IRB approval. This survey provided individuals an opportunity to express their opinions on certain statements, ideas, and beliefs about the current mandated standardized testing system, while also collecting background information for comparing data such as differences between how much someone from a D ranked school would support standardized testing compared to someone from an A ranked school. Most teachers and faculty …

Not An Afterthought: Addressing The Academic And Social Challenges That Create Barriers To Belonging For Transfer Students, Brooke Jankowsky

Honors Theses

This thesis examines the academic and social barriers to belonging for transfer students at four-year institutions, with particular attention to the University of Mississippi. The goal is to bring attention to the issues that surround transfer student populations in general by identifying some of the most pressing structural and interpersonal challenges that shape their experiences. A qualitative approach was used, drawing on existing literature, prior unpublished research at the community college level, and reflective analysis to explore themes such as transfer shock, creating and maintaining social networks, and gaps in institutional support. Findings suggest that transfer students often face a …

A.I. And Education: The Relationship Between Policy And A.I. Implementation In Louisiana K-12 Schools, Johnny R. Moore Jr

Honors Theses

This research focuses on A.I. policies in Louisiana K-12 education, trying to figure out what the best possible policies would be to ensure that students are using A.I. as a tool rather than a crutch to rely on. This goes through the history and background of technology implementation and educational policies in Louisiana. The research focuses on current A.I. policies in the state, if any, and then evaluates other states policies around the country. Teachers and administrators from around the state were surveyed on this and were also asked on their opinions on A.I. in the classroom.

Sustainability Strategies For Solo And Small Medical Practices In Kenya, Milcah Achieng' Odeny

Walden Dissertations and Doctoral Studies

No abstract provided.

Asymmetric Synthesis Of Borylated Amines Via Rhodium Catalyzed Hydroboration Of Allylamine Derivatives: Surprising Role Of Counterions And Accelerators, Rukshani Wickrama Arachchilage

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The Catalytic Asymmetric Hydroboration (CAHB) reaction is a valuable method for synthesizing chiral organoboron compounds. Nevertheless, key mechanistic details, including catalyst activation, ligand effects, and rate-determining steps, are difficult to generalize and remain not fully understood. Building on previous research from the Takacs group, this work explores acyclic N-acyl allylamines as substrates in rhodium-catalyzed hydroboration and investigates the formation of active catalysts from various rhodium precursors, the role of counterions (e.g. BF₄, BArF-), ligand-to-metal ratios, and the impact of external fluoride additives (e.g. TBAT). Hydroboration of acyclic N-acyl allylamines achieves up to 90% yield and 99 : 1 …

Voltage-Sensor–Targeting Modulators Of Iks: Identifying Critical Functional Groups Of C28 Via Electrophysiology And Sar Modeling, Jiacheng Huang

McKelvey School of Engineering Graduate Student Theses & Dissertations

I_Ks (KCNQ1/KCNE1) channels are essential for cardiac repolarization, and their dysfunction contributes to arrhythmogenic disorders such as Long QT Syndrome type 1 (LQT1). Pharmacological activation of I_Ks has therefore emerged as a promising therapeutic strategy. C28, a recently identified voltage-sensor–targeting activator, has been shown to markedly shift KCNQ1/KCNE1 voltage dependence and enhance current amplitude, validating the voltage-sensing domain (VSD) as a druggable site. However, the structural determinants that underlie C28’s activity remain incompletely understood. In this study, we aimed to identify critical functional groups of C28 by screening a structurally diverse set of C28-like analogs and evaluating their …

Toward Vehicle-Agnostic Driving Signatures For Cognitive Impairment Prediction From Naturalistic Driving Data, Aadarsha Gopala Reddy

McKelvey School of Engineering Graduate Student Theses & Dissertations

This thesis studies whether naturalistic driving data can help predict binary Clinical Dementia Rating (CDR) status while accounting for differences across vehicles. The final analytic dataset comprised 26,968 participant-weeks from 304 participants. Weekly driving features were derived from real-world telematics data and combined with four demographic covariates. Primary model comparisons used leave-one-participant-out (LOGO) cross-validation, with one individual held out at a time and pooled participant-level metrics used as the main reporting surface.

The main comparison includes six model families evaluated on the same dataset under a shared LOGO framework. Performance remained modest overall. GRU-DANN had the highest participant-level ROC AUC …

Computational Ligand-Receptor Simulations Of Fluorinated Morphine Derivatives Using Pymol, Mirabella Romano, Emily Chen

Student Scholar Symposium Abstracts and Posters

The opioid epidemic impacts 60 million people worldwide every year. Morphine, a commonly prescribed opioid, binds to the μ-opioid receptor (MOR) in the body via protonation of its tertiary amino group and the MOR. An unfortunate side effect of this binding process is its non-selectivity in both peripheral and central tissues. While activation within inflamed peripheral tissues results in pain relief, activation within central tissues results in the unwanted and addictive side effects of opioids. Because there is a pH discrepancy between healthy (central) and inflamed (peripheral) tissues, selective binding in the inflamed tissues could provide pain relief without addictive …

The Weight Of The Unknown: Xenophobia In Lucía Puenzo’S Xxy, Daylen Motamed

Student Scholar Symposium Abstracts and Posters

This project examines how Lucía Puenzo’s film titled XXY critiques societal responses to unique identities (specifically intersex as an example), asking how xenophobia and normative gender expectations shape the marginalization of bodies that exist outside the binary. Situating the film within scholarship on queer adolescence and intersex representation, the analysis of this poster will argue that XXY exposes how institutions such as medicine and family reinforce harmful notions of “normalization.”

Drawing on close textual analysis of key scenes and engagement with critical sources, including Guillermo Olivera’s work on space and visibility and testimonies from intersex individuals, this study investigates how …

Discrepancies In Pediatric Oral Health, Tyler B. Truong

Student Scholar Symposium Abstracts and Posters

In 2024, data was collected by the CDC on untreated tooth decay. From that data, children living in low-income households had an estimated 18.8% of tooth decay untreated, almost triple the amount when compared to children from middle to high income households (6.6%). As the income disparity continues to grow in the US, it is critical that we implement strategies to aid lower income communities in providing their children with proper oral hygiene tactics. In order to understand how communities can help promote healthy oral hygiene for their children, a survey of dentists from various areas was conducted to see …

L'Empire De L'Élégance: Histoire Et Marketing Du Luxe En France (The Empire Of Elegance: The History And Marketing Of Luxury In France), Kayleigh Gilbert

Student Scholar Symposium Abstracts and Posters

This thesis explores how France established and maintains its global leadership in the luxury sector by transforming high-end consumption from a tool of royal power into a modern economic pillar. The central research examines the historical evolution of French luxury, moving from the court of Louis XIV at Versailles to current global marketing, as well as how the strategic use of France’s national identity creates a manufactured desire that goes beyond a physical product. Within the context of luxury history and consumer economics, the project builds upon the work of scholars like William Beik and Michael Kwass to show how …

2026-05-06 Desification Of The Met Gala, Hadia Noor Ahmed

The Spectator Online

No abstract provided.