Digital Commons Network^™

Short-Term Bayesian Influenza Forecasting In A Hospital Environment Using A Linear Kalman Filter., Shankar Kaleeswaran Mani, Grzegorz A Rempala, Eben Kenah, Fernanda L Schumacher

Ambulatory and Primary Care Articles

Accurately forecasting the weekly number of influenza (flu) lab tests and positive cases is important for hospitals as they work to plan staffing, manage supplies, and provide timely patient care. In this paper, we describe a practical use of a Bayesian Kalman filter to forecast weekly flu tests and positives in a hospital setting. Using data from a large hospital system in Ohio, we show that this approach, which blends real-time hospital information with historical patterns, offers a dependable way to anticipate flu-related patient volume as far as four weeks ahead.

Current Options And Future Trends In Green Fuels Storage, Muhammad Anas Maqbool, Md Jahir Rizvi, Yeaw Chu Lee, Pablo Borja Rosales

School of Engineering, Computing and Mathematics

The global transition to renewable energy underscores the urgent need for safe, efficient, and cost-effective storage solutions for green hydrogen and green ammonia. This review critically examines their fundamental characteristics and unique behaviours, emphasising storage, handling, and integration engineering challenges. To identify the influential studies, knowledge gaps and future trends in the research area, a systematic Scopus-based bibliometric and data analysis is conducted. A novel approach is adopted to identify the better green energy storage option between green hydrogen storage and green ammonia storage, combining a risk-mitigation assessment framework, strengths, weaknesses, opportunities, threats (SWOT) analysis, and a multicriteria taxonomy based …

Machine Learning-Based Prediction Of Proximal Junctional Pathology After Adult Spinal Deformity Surgery: A Systematic Review And Diagnostic Test Accuracy Meta-Analysis, Shaan Patel, Shiva A. Nischal, Yi Hein Chai, Kush M. Kale, Kevin Hines, Joshua Pelta-Heller, Jack Jallo, James S. Harrop, Srinivas K. Prasad

Department of Neurosurgery Faculty Papers

BACKGROUND: Proximal junctional kyphosis (PJK) and failure (PJF) remain challenging and incompletely predictable adverse event following adult spinal deformity (ASD) surgery. Machine learning (ML) models have been proposed to improve risk stratification, but performance varies and clinical applicability remains uncertain. A systematic review and diagnostic test accuracy meta-analysis was performed to synthesize the predictive performance of ML-based models for proximal junctional pathology after ASD surgery.

METHODS: PubMed, Embase, and CENTRAL were searched from inception to February 2026. Studies developing or validating ML models predicting PJK or PJF following ASD surgery were included. Diagnostic performance was synthesized using random-effects models, pooling …

Uncovering Cytoskeletal Length Control From Growth Trajectories Using Sparse Dynamical Modeling, Carson Hearn

Theses

Understanding the governing equations of biological filament dynamics is essential for predicting cellular behavior, yet these equations are often difficult or impossible to derive directly from first principles. This thesis investigates the use of Sparse Identification of Nonlinear Dynamics (SINDy) as a unified, data-driven framework for discovering, validating, and refining governing equations from both simulated and experimental data. Focusing on biological filament processes, including growth, disassembly, and severing, this work is designed not only to apply SINDy, but to systematically demonstrate that it is a reliable and generalizable tool for modeling complex biophysical systems. To establish this, SINDy is first …

Unc-45b As A Potential Chaperone For The Transcription Factor, Gata-4, Kaylah Owings

Electronic Theses and Dissertations

The cardiac myosin–specific chaperone UNC-45B has been shown to physically interact with the cardiac myosin transcription factor GATA-4. Specifically, this interaction occurs within the chaperoning region of UNC-45B, known as the UCS domain. However, the precise nature of this interaction has not yet been fully elucidated. The present study was conducted to confirm earlier findings and to evaluate whether UNC-45B functions as a chaperone for GATA-4 using bioinformatic approaches. Analysis of the interaction using AlphaFold 3 modeling verified not only that binding occurs at the UCS (chaperoning) domain of UNC-45B, but also that the interaction is associated with an increase …

Pharmacogenomic-Guided Prescribing And Polypharmacy Across Age Groups In Obsessive-Compulsive Disorder: A Retrospective Study, Sheldon R Garrison, Matthew W Boyer, Anthony W Zoghbi, Rachel A Schwartz, Nicolette Weisensel, Martin E Franklin, Madeline M Hartig, Maharaj Singh, Sreya Vadapalli

Faculty, Staff and Students Publications

Background: This study evaluated medication utilization in children, adolescents, and adults with obsessive-compulsive disorder (OCD), a chronic psychiatric condition characterized by intrusive thoughts and repetitive behaviors. Although first-line treatments include selective serotonin reuptake inhibitors (SSRIs) and cognitive behavioral therapy (CBT), the heterogeneous biological underpinnings contribute to suboptimal outcomes, with 40-60% of individuals not responding to SSRIs. This complex phenotype often leads to psychotropic polypharmacy, which may be mitigated by incorporating combinatorial pharmacogenomic (PGx) testing into protocol-based care to identify potential gene-drug interactions.

Methods: A retrospective review was conducted of individuals with OCD aged 8 to 65 years who received either …

Genetic Analysis Of The X-Linked Adrenoleukodystrophy Gene Abcd1 In Drosophila Uncovers A Conserved Phenotype, Joshua Manor, Sharayu V Jangam, Hyung-Lok Chung, Pranjali Bhagwat, Jonathan C Andrews, Hillary Chester, Shu Kondo, Saurabh Srivastav, Juan Botas, Ann B Moser, Suzette M Huguenin, Michael F Wangler

Duncan NRI Faculty and Staff Publications

X-linked adrenoleukodystrophy (X-ALD) is a progressive neurodegenerative disorder caused by a loss-of-function (LOF) mutation in the ATP-binding cassette subfamily D member 1 (ABCD1) gene, leading to the accumulation of very long-chain fatty acids (VLCFAs). This disorder exhibits striking heterogeneity; some male patients develop an early childhood neuroinflammatory demyelination disorder, while other patients, including adult males and most affected female carriers, experience a chronic progressive myelopathy. Adrenocortical failure is observed in almost all male patients, with the age of onset varying, sometimes being the first diagnostic finding. The gene underlying this spectrum of disease encodes an ATP-binding cassette (ABC) transporter that …

Jacksonian Democracy: Triumph Or Tragedy?, Gabe Blumer

Undergraduate Theses and Senior Projects

This capstone paper analyzes Andrew Jackson's presidential impact on democracy and discusses its strengths and weaknesses as a whole. It goes over the impact on white men, black Americans, and Native Americans in particular.

Prinsip Military Necessity Dalam Hukum Internasional Humaniter, Hersapta Mulyono

Jurnal Hukum & Pembangunan

Abstract

Establishing Sustainable Vegetation On A Challenging Legacy Ccr Site, Derek Oosterhouse, Blake Arthur

World of Coal Ash Proceedings

American Electric Power (AEP) is closing and restoring a legacy Coal Combustion Residuals (CCR) site in Ohio that once held a power plant that pioneered innovative steam generation technology. The plant was closed in 1975. Today, the legacy CCR site is being transformed back to natural, sustainable vegetation. To comply with and close the Stormwater Pollution Prevention Plan (SWPPP) permit, permanent stabilization is required on the site. AEP, one of the largest electric companies in the country, holds a core principle to respect the environment through creative sustainable solutions. AEP connected with Profile Products, the world’s largest manufacturer and supplier …

A Cost-Effective, Low-Impact Remedial Approach For Metals: Utilizing Phyto-Enhancement To Accelerate Ph Adjustment Of Shallow Groundwater, Jerry Wylie, Thomas Colton

World of Coal Ash Proceedings

SynTerra will present a unique, low-cost, low-impact approach to metals remediation in shallow groundwater at a former industrial site located in the Atlantic Coastal Plain. The approach employs pH adjustment of groundwater using agricultural lime coupled with the use of daikon radish to augment lime contact time and to increase depth of soil augmentation. This method is designed to be a more sustainable, less resource-intensive, and less technically challenging remedial alternative with lower estimated overall costs. The primary corrective action—source removal—has been completed. However, the oxidation of residual sulfide-bearing minerals has resulted in persistent low-pH groundwater, which increases the solubility …

Life History, Stock Status, And Movement Ecology Of Narrow-Barred Spanish Mackerel, Scomberomorus Commerson (Lacépède, 1800) In The Southern Arabian Gulf, Mohamed Abdulla Almusallami

Thesis/ Dissertation Defenses

The narrow-barred Spanish mackerel, Scomberomorus commerson, is the most commercially valuable pelagic fish species in the Arabian Gulf. This thesis integrated three studies to comprehensively assess the life history, stock status, and movement ecology of this species in Abu Dhabi waters. Life history traits were characterized from data collected during a 15-month monitoring program (January 2019–May 2020). Fork length ranged from 30.5 to 132 cm. Growth parameters were k = 0.14–0.15 year⁻¹ and L∞ = 128.9–135.4 cm for males and females, respectively. Size-at-maturity (Lm₅₀) was 78.7 cm FL for females and 69.7 cm FL for males. The spawning season occurred …

Dictionary Of A Vietnamese-American* Borderland, Ngọc Hải Nguyễn '26

Senior Scholarly and Creative Symposium

This project, composed of a contextualising research paper and an autoethnographical writing creative component, explores the conceptualisation of Anzaldúa's (2021) borderlands by applying to the author's own experience as a Vietnamese-native student growing up along multiple cultural points of inquiry (primarily the American culture). The core research question of this paper is What does it mean to be at the crossroads of many cultures? In the research paper, the author first contextualises the current discourse on borderlands, along with a justification for their usage of storytelling as a mode of inquiry. The author implements a framework theorised through Loveless (2019) …

Screening Novel Secreted Proteins For Their Effects On Pancreatic Islet Function Using Qpcr-Based Gene Expression Analysis, Deepti Agarwal, Neha Mishra, Marcus Seldin

Cumberland Medica

Type 2 diabetes (T2D) involves progressive dysfunction of pancreatic β-cells and systemic insulin resistance. Although a handful of secreted factors acting on pancreatic islet have emerged as important therapeutic targets, many additional signaling processes remain unknown. The identification of such mediators can make a new contribution to the regulation of islet biology and serve as another approach for disease treatment. This study aimed to investigate whether three novel peptides could modulate islet-specific gene expression in vivo. Methods: Male C57BL/6J mice were injected with proteins then pancreatic tissues were collected six hours post-treatment. Total RNA was isolated, converted to cDNA, and …

Paternalism Under The Guise Of Partnership: How Modern Treaties In Canada Fall Short In Building Nation-To-Nation Relationships Between Indigenous Governments And The Crown, Maci Clements

Culture, Society, and Praxis

Indigenous nations in Canada have an inherent right to self-determination of their governments and traditional territory; however, how best to implement and ensure this right remains up for debate within Indigenous scholarship. In contrast to such debates, the Canadian State boasts the modern treaty process as the apex tool of Indigenous self-governance, permitting legitimate nation-to-nation relationship building. In this paper, I use an Indigenous feminist analytical framework to investigate if the negotiation and arrangement of existing modern treaties successfully accomplish the goal of creating a nation-to-nation partnership between Indigenous nations and the Crown. Following a critical reading of the modern …

The #Blackgirlmagic Of Educational Leadership: Self Identity And Leadership, Sascha Elayne Naa Yarkai Quartey

Educational Leadership Theses, Dissertations, and Student Creative Activity

The ongoing underrepresentation of Black women in PK–12 principalships and district-level leadership roles impacts equitable representation in educational decision-making spaces and the opportunities for students to see leaders who reflect and affirm their identities. Existing research highlights barriers such as hypervisibility and invisibility (Alfred, 2018), isolation, stereotype threat, and limited mentorship (Dumas, 2022; Julien, 2019), and yet these experiences may not be connected to leadership theory in ways that honor the resilience, cultural knowledge, and transformative practices Black women enact. This study addresses that gap through an autoethnographic examination of a personal leadership journey as a Black woman in PK–12 …

Management Of Libman-Sacks Endocarditis: The Role Of Anticoagulation And Immunosuppressive Therapy, Klaudia Matanaj, Demi Poulathas, David Altimore

Rowan-Virtua Research Day

Background: Libman-Sacks endocarditis (LSE) is a nonbacterial thrombotic endocarditis detected in 10-40% of patients with systemic lupus erythematosus (SLE), depending on imaging modality. LSE is strongly associated with antiphospholipid syndrome (APS). The condition significantly increases the risk of cerebrovascular accidents and inpatient mortality compared to SLE without cardiac involvement. Despite these serious complications, optimal management remains uncertain. Objective: To review the current evidence on the pathophysiology and management of LSE. Methods: A literature review was conducted using 12 peer-reviewed articles addressing LSE pathophysiology, clinical outcomes, and treatment strategies. Results: Combination anti-inflammatory and antithrombotic therapy achieved 76% …

Understanding The Immune Responses Of Macrophages And Neutrophils In Synovial Fluid And Post-Operative Joint Environments, Allison Noelle Snyder

Rowan-Virtua Research Day

Periprosthetic joint infections (PJI) are devastating complications of total joint replacement (TJA). Even with aggressive antibiotic treatments, PJI recurrence rates are >17%, and 5-year survival is only 87.3%. Understanding the levels of inflammatory markers and cell types present at different timepoints is crucial in maximizing antimicrobial therapy and preventing adverse outcomes following TJA. This study tests the hypothesis that the synovial fluid environment of PJI induces immunosuppression in human macrophages, thereby hindering their ability to kill bacteria.

Effect Of Parkinson’S Disease On The Lateralization Of The Digastric Muscle In A Rodent Model, Estelle Richardson, Francois Gould

Rowan-Virtua Research Day

In Parkinson’s disease, the loss of dopaminergic neurons in the substantia nigra can cause dysphagia, which affects all phases of swallowing. In swallowing, bilateral pairs of muscles under the control of independent unilateral neural mechanisms must simultaneously activate to coordinate their movements and produce a swallow. However it is unknown how Parkinson’s disease impairs the activation of the right and left sides of those muscles. In this study we tested how Parkinson’s disease impacts the lateralization of the digastric muscle in rats. We hypothesized that Parkinson’s disease will cause a difference in activation of the right and left digastric muscles …

Atypical Presentation Of Alpha-Gal Syndrome Identified During Evaluation Of Transient Neurologic Symptoms, Austin J. Wong, Todd Schachter

Rowan-Virtua Research Day

Alpha-gal syndrome (AGS) is an IgE-mediated hypersensitivity reaction to galactose-α-1,3-galactose, typically associated with tick exposure and delayed allergic reactions to mammalian meat products. While most commonly presenting with urticaria, gastrointestinal symptoms, or anaphylaxis, atypical and systemic manifestations remain poorly characterized.

We present the case of a 39-year-old male with minimal vascular risk factors who developed acute onset shortness of breath, chest pressure, and transient neurologic symptoms concerning for a transient ischemic attack. Extensive cardiac, vascular, and autoimmune evaluation was largely unremarkable aside from abnormalities in lupus anticoagulation screening and elevated homocysteine and protein C levels.

Further evaluation revealed elevated alpha-gal–specific …

The Effects Of Blue Light From Technology On Sleep Health In Adolescents And Young Adults: A Literature Review, Matthew F. Dilloian, Dianne Langford Ph.D., Charalampos Papachristou Ph.D.

Rowan-Virtua Research Day

Background: Digital screens, such as smartphones, computers, and tablets, emit blue light in the short wavelength range of ~400–500 nm. This exposure impacts the suprachiasmatic nucleus, the brain's biological clock, which regulates the sleep-wake cycle via melatonin secretion from the pineal gland. Blue light is known to suppress melatonin, potentially leading to poor sleep quality and sleep disruptions. Significance: With approximately 90% of Americans using electronic devices within one hour of bedtime, understanding these effects is critical for public health. Previous research often excluded young adults, specific target populations, like athletes, or focused solely on the biochemistry of blue …

Lactate-Induced Mitochondrial Magnesium Uptake And Its Metabolic Implications In The Mcardle’S Disease Model, Thiruvelselvan Ponnusamy, Jeremy Mehta, Haris Waseem, Marianne Assogba, Dianne Langford, Natarajaseenivasan Kalimuthusamy, Shanmughapriya Santhanam

Rowan-Virtua Research Day

McArdle disease, caused by mutations in the PYGM gene, impairs glycogenolysis in skeletal muscle, reducing lactate production and leading to energy deficits, fatigue, and risk of rhabdomyolysis. Using a CRISPR/Cas9-generated PYGM knockout (KO) rat model, we investigated whether reduced lactate production disrupts mitochondrial magnesium (Mg²⁺) homeostasis. KO rats failed to elevate lactate during static muscle contraction and showed diminished mitochondrial Mg²⁺ uptake, disrupted ATP synthesis, and impaired mitochondrial respiration. In vitro, caffeine-stimulated KO myotubes lacked lactate production and mitochondrial Mg²⁺ uptake despite preserved Ca²⁺ oscillations. Raising glucose concentration restored lactate levels, rescued mitochondrial Mg²⁺ transport, and improved metabolic output in …

Becoming Mandan: The Collaborative Life History Of Robert O’Brien, Douglas D. Meigs

Sociology and Anthropology Theses, Dissertations, and Student Creative Activity

This thesis examines how separation from—and later discovery of—an Indigenous family and culture shapes ethnic identity formation. Grounded in Charles Horton Cooley’s theory of the looking-glass self, it uses collaborative life history methodology to analyze the process of Indigenous identity formation experienced by Robert O’Brien, a Native American orphan who discovered his Mandan, Hidatsa, and Arikara (MHA) heritage as an adult. Drawing on two decades of reflexive research, unstructured interviews, participant observation, and archival documents, the case study shows how O’Brien’s sense of identity developed in response to shifting and often contradictory social mirrors.

Metabolite Profiling Facility (Mpf), Bruce R. Cooper, Purdue University Office Of Research

University Research Core Facility Boilerplate Descriptions

No abstract provided.

Invasive Macrofungi In The United States: A Mushrooming Crisis, Emily Torres

Student Theses 2015-Present

Globalization has accelerated the spread of invasive species, making them one of the largest contributors to biodiversity loss worldwide. While invasive macrofungi remain largely absent from scientific discourse on invasive species, they represent a growing ecological concern throughout the United States. Invasive macrofungi disrupt forest ecosystems, alter soil communities, and displace native fungi. Beyond these ecological impacts, their presence and establishment profoundly affect human-nature relationships, most notably mushroom foraging and cultivation practices. This paper adopts a multidisciplinary approach to examine the ecological, economic, and anthropogenic impacts of invasive macrofungi in the United States. Chapter 1 provides a quantitative overview of …

May 6, 2026 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Hawks' Herald -- May 6, 2026, Roger Williams University

Hawk's Herald

No abstract provided.

Jtc 26: The Best Decision They Almost Did Not Make, Alex Sims

University of Mississippi News

This story is part of the 2026 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.

Dropping Into The Expressive Art Therapy: A Community Engagement Arts Based Project, Sydney C. Smith, Meg Chang

Expressive Therapies Theses

This community engagement capstone explores how expressive arts practices (EXAP) may complement surf-based programming by supporting reflection, empathy, and meaning-making among participants. Research has demonstrated that surf therapy can promote emotional well-being, resilience, and social connection through embodied engagement with the ocean and supportive community environments. Integrating expressive arts practices within surf-based programs may extend these benefits by providing opportunities for reflection, creative expression, and interpersonal exchange. Grounded in expressive arts therapy (EXAT) theory and arts-based research (ABR) paradigms, this project examines how creative expression can support relational and emotional experiences within surf therapy settings. Using an arts-informed community engagement …

Treatment Of Propionic Acidemia With Acetate Donors, Chorlada Paiboonrungruang, Zhaohui Xiong, Xiaoxin Chen

Rowan-Virtua Research Day

Propionic acidemia (PA) is a rare autosomal recessive metabolic disorder caused by deficiency of propionyl-CoA carboxylase, resulting in toxic metabolite accumulation and impaired energy production. Current treatments are largely supportive, highlighting the need for targeted metabolic therapies. This study evaluates whether acetate donors can improve cell viability in a PA model.

Human hepatocyte (HepG2) control and PCC-deficient (PCCΔ) cells were treated with triacetin, sodium acetate, or acetylcarnitine. Dose-response studies (0.1–10 mM) showed no cytotoxicity. Propionate exposure identified 800 μM as an optimal stress condition that reduced viability without excessive cell death.

Under propionate-induced stress, all acetate donors improved cell viability …