Digital Commons Network^™

Data-Driven Approaches To Investigate Cardiotoxicity Using Hipscs High Throughput Screening, Danny Vu

Theses - ALL

Recent advances in human induced pluripotent stem cell (hiPSC) technology have enabled the development of high-throughput platforms for cardiotoxicity screening. However, conventional analytical approaches remain limited by time-intensive processing, manual annotation requirements, and reduced scalability for large datasets. To address these challenges, calcium fluorescence signals from human induced pluripotent stem cell-derived cardiomyocytes (hiPSC CMs) were analyzed using a high-throughput imaging platform and complementary machine learning frameworks. First, a feature-based supervised learning approach using engineered waveform descriptors and low-dimensional signal embeddings enabled rapid and interpretable screening of large chemical datasets, with combined features improving predictive performance relative to engineered features alone. …

Women In Literature And Their Ephemeral Bodies, Madeline Zafon-Whalen

English Honors Theses

This thesis is a comparative analysis of women writers from the twentieth to twenty-first century. Works by authors such as Virginia Woolf, Margaret Atwood, and Otessa Moshfegh, contain an emerging pattern and relationship linked through an ephemeral bodied aesthetic which depicts women's bodies as deconstructed, intangible, and undefined.

The first chapter analyzes works by Woolf, including To the Lighthouse and A Room of One's Own. Starting in the modernist age we see the body coming into question, becoming denaturalized while the institution of the "novel" is renewed through women's contributions to the literary canon. Women’s productivity, and the potential to …

The Role Of Gender And Salient Social Identities In Producing Vulnerability And Maladptation To Flooding In Koraso, Berekum, Ghana, Kingsley Damoah Oppong

Geography ETDs

This paper highlights how social identities like polygamy, illiteracy, and ethnicity hinder rural women farmers in Ghana from adapting to climate change. It advocates for an intersectional approach to address these challenges, moving beyond simplistic gender binaries. Using qualitative interviews (n=49) in a flood-prone village in Berekum, Ghana, the study reveals how these identities intersect with gender roles and colonial legacies, exacerbating vulnerability. It bridges Black feminist thought with climate change, an underexplored area, offering insights into climate change and environmental studies, as well as Black feminist scholarship. This research urges a reevaluation of how we understand climate change in …

Affective Labor And Deservingness In Global Care Economies: A Comparative Film Analysis In Brazilian And U.S. Cinema, Débora Ferreira Leite

Theses - ALL

This thesis examines how contemporary cinema constructs narratives of migration, care labor, and social mobility through representations of Latina caregivers. Focusing on two films, Knives Out (2019), directed by Rian Johnson, and Diários de Intercâmbio (The Secret Diary of an Exchange Student, 2021), directed by Bruno Garotti, the project explores how cinematic narratives shape cultural understandings of care work, migration, and the American Dream. Although these films emerge from different national industries and genres, both center Latina women navigating transnational labor arrangements and aspirations for social mobility in the United States. Drawing on scholarship on the global care economy, transnational …

Talking To The Eyes: Paradoxes Of Ineffability And Effusivity In Mark-Making, Theodore Xavier Berg

Theses - ALL

Redefining mark-making as an active form of material signification has helped me understand my experience of the paradox of ineffability. This experience is as accurately described by the term effusivity as it is by ineffability, because it is not a matter of what cannot be expressed, but rather of what cannot not be expressed; of the experience that inescapably accompanies expression and signification. As our material means of expression and signification evolve digitally, the consequences of their contradictions become more discernible.

Polymer Concentration Driven Tuning Of Drug Release In Nano-In-Microparticle Systems For Immunomodulation, Jason Bae

Theses - ALL

Osteoarthritis (OA), a disease caused by the wearing and tearing of articular cartilage, affects over 32.5 million Americans. Synovial inflammation is now recognized as a major contributor to OA progression and pain. Activated synovial macrophages in an OA joint are believed to play a major role in low-grade inflammation found in OA. Bisphosphonates such as zoledronic acid (ZA) are known to induce apoptosis specifically in macrophages and several of them are being evaluated as a disease-modifying osteoarthritis drug in clinical trials. Zolendroic Acid (Zol) is a biphosphonate that is most commonly used for treatments in bone-related diseases. Previous research reported …

Evapotranspiration Everywhere, All The Time: Towards A Unified View From Earth Observation, Joshua B. Fisher, Martha C. Anderson, Diego G. Miralles, Kanishka Mallick, Paul C. Stoy, Youngryel Ryu, Wim G. M. Bastiaanssen

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Scientists want to know everything, everywhere, and all the time. This is particularly true in Earth science, where we seek to understand processes that span from the molecular to the planetary scale in how the world works, how it affects us, and how we impact it—especially the water cycle. Evapotranspiration (ET) was the last component to be measured in closing the water cycle: for decades, closing the water budget meant adding up all the measurable components, then inferring ET as the residual. Early measurements relied on water loss from pans and weighing lysimeters, followed by sensors inserted into plants to …

Assessing Knowledge And Decision-Making In Basic Genomics Among Adolescents And Adults, Sidharth Masarur

Honors Scholar Theses

Background

Genetic testing and genomic sequencing are increasingly part of pediatric care, yet many adolescents and parents lack the knowledge needed to make informed decisions. Prior studies show gaps in understanding, even among highly educated families, raising concerns about the adequacy of consent and assent. Little is known about when youth begin to comprehend genomic sequencing and how this impacts their own genetic and genomic decision-making.

Objective

To assess baseline genomic knowledge among adolescents and parents, examine its influence on decisions about genetic testing and sequencing, and identify opinions on appropriate age thresholds for youth participation in testing decisions.

Methods …

Geometric Approaches To Memory Formation In Soft Matter, Gentian Muhaxheri

Dissertations - ALL

The primary focus of this dissertation is the development of a geometric framework for understanding memory formation in systems composed of interacting hysteretic elements, or hysterons. Using tools from bifurcation and catastrophe theory, this work provides a description of how complex memory behaviors emerge from the structure of the system's configuration space and the system bifurcations under external driving. As a concrete model system, we study networks of connected rubber balloons subjected to different inflation protocols. Under pressure control, the system maps naturally onto a Preisach-type system of non-interacting hysterons and exhibits return point memory. In contrast, under volume control, …

Symmetries Of Legged Locomotion: Theory And Applications In Animals And Robots, Jiayu Ding

Dissertations - ALL

Legged locomotion in animals and robots is naturally modeled as a hybrid dynamical system: smooth body evolution is repeatedly interrupted by discrete contact events such as touchdown and liftoff. Although symmetry is a powerful organizing principle in smooth dynamical systems, a comparably systematic symmetry framework for hybrid legged locomotion remains underdeveloped. This dissertation develops such a framework for a scoped class of periodic hybrid locomotion models and uses it to relate theoretical gait analysis, animal locomotion studies, and robotic gait generation. The dissertation first extends symmetry notions from autonomous dynamics to hybrid legged systems and distinguishes symmetries of the hybrid …

Development Of Dual-Stimuli Responsive Polymer-Coated Gold Nanoparticles And Their Surface Engineering Via Polyelectrolyte Layer-By-Layer Assembly, Buddhini Chathurangi Nugaduwa Vithanage

Dissertations - ALL

The modification of nanoparticles with combinations of low critical solution temperature (LCST) polymers and polyelectrolyte (PE) layers is studied. Three n-isopropylacrylamide-co-acrylamide polymers were synthesized in which charges could be varied from neutral, to negative or positive by way of incorporating poly acrylic acid (pAAc) or poly 4-vinylpyridene (p4VP) units. Polymerization centered around a disulfide initiator, which when reduced produced two polymer chains and a convenient linkage to gold NPs (NPs). The resulting LCST-NPs conjugates possessed sharp phase changes at critical temperatures (TC), while the incorporation of pAAc or p4VP allowed for tuneable charges and pH sensitivity. Studies with 1H-NMR and …

A City’S Neglectful Past: Young Black Mothers And The Creation Of A Reproductive Health Crisis In The Urban North 1900 - 2005, Semaj Imane Campbell-Blakes

Dissertations - ALL

"A City’s Neglectful Past: Young Black Mothers and The Creation of A Reproductive Health Crisis in the Urban North 1900‐2005" examines how the promise of northern liberalism concealed enduring forms of racial inequality in reproductive health. Centering Syracuse, New York, a city long celebrated for its nineteenth-century abolitionist legacy, the project reveals how its twentieth-century institutions expelled pregnant Black girls from schools, criminalized their sexuality, and oversaw some of the highest Black infant-mortality rates in the nation. Through this lens, Syracuse becomes a case study in the contradictions of progressive reform, where liberal ideals coexisted with structural neglect and moral …

Nanoparticle-Based Therapy For Peripheral Artery Disease: Evaluation Of Collagen Reduction And Fibrosis Mitigation In Ischemic Tissue, Tresha Nguyen

2026 Spring Honors Capstones Projects

Peripheral Artery Disease (PAD) is characterized by reduced blood flow, ischemic injury, and fibrosis, which collectively impair tissue function. Current treatment strategies are limited in their ability to target fibrotic tissue and restore normal function effectively. This study evaluates the therapeutic potential of drug-loaded nanoparticles to reduce fibrosis in ischemic tissue. Nanoparticles were synthesized and characterized for in vivo application. Tissue samples from experimental groups, including saline control, blank nanoparticles, free drug, and drug-loaded nanoparticles, were analyzed using Masson’s Trichrome staining to quantify collagen deposition. Histological images were processed using image analysis software to determine the percentage of collagen area. …

“The Least You Can Do Is Start A Meeting With A Karakia”: Challenging The Culture Order In A New Zealand Cricket Organisation, Stephanie Foxton, Tame Pere

Journal of Global South Sport Studies

Previously, it was documented that cricket operated as a tool of colonisation, serving to spread British culture and values across the empire, reinforcing British identity and asserting cultural superiority (Baucom, 1999). In places like Australia and Aotearoa New Zealand (NZ), cricket became a cornerstone of colonial social life, solidifying the dominance of British culture. Employing the Colonial Matrix of Power framework (Mignolo, 2007; Quijano, 2007) alongside the concept of the culture order (Holmes, 2018), this article aims to understand how Aotearoa NZ’s ever-evolving cricket culture sustains, and in some cases challenges, the dominance of Pākehā/British norms. By weaving these theoretical …

Nitrogen And Phosphorus Fertilization Shifts Fungal And Bacterial Community Composition And Functional Groups In Temperate Forest Soils, Caroline Frances Plecki

Theses - ALL

Anthropogenic nitrogen (N) deposition is known to alter nutrient limitation in temperate forests, yet belowground microbial responses under shifting phosphorus (P) and N+P availability remain unclear. Using a long-term N × P fertilization experiment (MELNHE), we quantified fungal and bacterial community responses across organic and mineral soil. Nutrient additions restructured community composition without changing alpha diversity, indicating taxonomic turnover rather than richness loss. Nitrogen reduced ectomycorrhizal (EM) dominance and increased the relative abundance of saprotrophic fungi in the organic soil layer, including declines in nitrophobic taxa such as Cortinarius. Phosphorus structured fungal guild ratio non-linearly, with EM fungal dominance maximized …

“It Makes Me Wonder: How Can We Build Truly Inclusive, Co-Taught Environments That Support Every Student, Not Just Those With More Easily Accommodated Needs?”: Preservice Teachers’ Self-Perceptions Of Preparedness For Working With Diverse Learners, Sara H. Petit-Mcclure

Dissertations - ALL

The student population in the United States is increasingly diverse, yet students from marginalized groups — particularly those with intersecting identities including disability — continue to experience poorer outcomes and limited opportunities. In response, some universities have developed programs to prepare teachers to create inclusive, culturally sustaining opportunities for students from marginalized groups. This qualitative study analyzed self-perceptions of preparedness among nine preservice teachers recruited from two elementary dual-certification programs in the Northeastern United States. The study asks: What are the self-perceptions of preparedness to work with diverse learners among preservice teachers enrolled in dual certification programs? Drawing on Disability …

Rewriting The Script: Representations Of Virginity In Teen Dramedies (2019-2025), Sophia Elizabeth Condemi

Theses - ALL

Over the past three decades, youth sexual activity has steadily declined, with members of Generation Z (those born between 1997 to 2012) reporting lower rates of sexual activity than previous generations, and in many cases, delaying their first sexual experiences. This shift raises the question of whether contemporary teen television reflects these changes in sexual behavior. This thesis examines ten popular teen dramedies that aired between 2019 and 2025 on streaming video services to see whether new scripts surrounding virginity emerge or if traditional narratives persist. Using qualitative textual analysis guided by sexual script theory and relational dialectics theory, the …

The Impact Of Stress On Selective Attention Among College Student Athletes, Jayla K. Mcgaffin

Honors Theses

Student athletes face unique stressors from balancing academic and athletic demands (Lopes Dos Santos et al., 2020), which may deplete cognitive resources and impair focus. The present study examined the relationship between perceived stress and selective attention among college student athletes. Stress was conceptualized as the interaction between external pressures and individual coping responses (Lazarus & Folkman, 1984). Twenty undergraduate student athletes from the University of New Haven completed the Perceived Stress Scale (PSS-14) and a computerized Flanker task measuring selective attention, but only eighteen were used in the final correlation analysis. It was hypothesized that higher levels of perceived …

Cell Cycle Inhibition: Illudin S And Its Effects On Cdk2 In Ewing Sarcoma, Stephanie Diez, Natalie Flores, Alexandria Hernandez, Viviana Palacios, Terry Jo Shackleford

Cell and Molecular Methods

Ewing Sarcomas are aggressive round cell mesenchymal neoplasmas that have a high occurrence in children and young adults. CDK2 is a protein that is involved in the G1 phase of the cell cycle, which promotes the transition to the S phase. CDK2 kinase activation is mainly observed in the G1/S-phase transition.3 CDK2 binds to Cyclin proteins is responsible for entry and progression, thereby leading to maximal apoptosis activity in the S-phase. Illudin S is a drug that has been known to target cancer-specific cells, such as leukemia. Illudin S, in general are a cytotoxic metabolite that comes from plants, specifically …

Yap1 Knockdown And Panobinostat Treatment Increase Apoptotic Response And Decrease Gene Expression In Ewing Sarcoma Cells, Luna Collazo-Garcia, Alejandra Favela Santos, Madeline Torres-Salazar, Isabella Toscano, Terry Jo Shackleford

Cell and Molecular Methods

Ewing sarcoma (EWS) is considered to be one of the most aggressive pediatric malignancies, often characterized by its dysregulated gene expression driven by oncogenic fusion proteins. The Hippo signaling effector Yes-associated protein 1 (YAP1) has been known in promoting cell proliferation, survival, and therapeutic resistance in multiple cancers. However, its role in Ewing sarcoma response to treatment remains unclear. This study investigated whether YAP1 knockdown enhances the sensitivity of Ewing sarcoma cells to the histone deacetylase inhibitor Panobinostat. Ewing sarcoma, ES8, cells were transfected with a YAP1-targeting siRNA (siYAP1) or a non-targeting control (siControl) and treated with DMSO, 0.1 μM, …

Everolimus Treatment Combined With Akt1 Knockdown Increased Apoptosis And Decreased Cell Proliferation In Ewing Sarcoma Cells, Arisha Arif, Alfie Barcenez, Sophia Ruter, Nicole Vanegas-Riddick, Terry Jo Shackleford

Cell and Molecular Methods

The purpose of this study is to use the gene AKT1, due to the interest in AKT1’s role in cancer cell proliferation, and the drug Everolimus, to determine if combined targeted therapy works as a more efficient therapeutic approach. Ewing Sarcoma has been connected to chromosomal translocations and is most common in pediatric patients. It is most often treated with chemotherapy and local treatments. It may be connected to the gene AKT1 due to how it regulates cell metabolism, growth, and proliferation. The gene mTOR is similarly connected to cell metabolism and proliferation, and is inhibited by the drug Everolimus. …

Sirna Knockdown Of Rptor Reduces Rptor Expression, Increases Brd4 Expression, And Alters Proliferation And Apoptosis In Ewing's Sarcoma Cells, Sergio Cipriano, David Leavitt, Michael Olivia, Liam Valdez, Terry Jo Shackleford

Cell and Molecular Methods

Ewing sarcoma is a highly aggressive cancer that primarily affects children and young adults. Although treatment options exist, many patients do not respond effectively, showing the need for improved targeted therapies. RPTOR is a key in mTORC1 complex which regulates cell growth, proliferation, and survival. LY2874455 is a selective pan-FGFR inhibitor that targets growth factor signaling pathways involved in tumor progression, and FGFR signaling interacts with pathways such as mTOR, making it a potential target for combination therapies. We hypothesized that silencing RPTOR in Ewing sarcoma cells would disrupt mTOR signaling and alter expression of genes linked to cell survival …

Everolimus And Sirna-Mediated Mtor Inhibition Reduces Proliferation And Promotes Apoptosis In Ewing Sarcoma Cells, Dylan Calvert, Malorie Martinez, Alexa Miner, Ellis Quiroga, Terry Jo Shackleford

Cell and Molecular Methods

Ewing Sarcoma (ES) is an aggressive pediatric bone cancer characterized by rapid cell proliferation and poor prognosis, making the identification of therapeutic targets critical. One of  the mechanistic targets is rapamycin (mTOR) signaling pathway, which is critical for regulating cell growth, proliferation, and survival. Abnormal activation of the mTOR signaling pathway has been linked to the progression of ES, as it drives uncontrolled cell growth and apoptosis resistance. Because mTOR represents a promising therapeutic target for ES treatment, we hypothesized that inhibiting mTOR activity through an siRNA-mediated knockdown or through Everolimus drug treatment, would reduce cell proliferation and promote ES …

Editorial 12(1), May 2026, Matthew R. Jamnik

The International Journal of Ecopsychology (IJE)

No abstract provided.

Artist Interview: Sarah Crooks, Sarah Crooks

The International Journal of Ecopsychology (IJE)

No abstract provided.

Developmental Ecological Psychology Meets Organicist Biology: The Example Of The Ecological Self, Catherine Read

The International Journal of Ecopsychology (IJE)

In this paper we outline an ecological-organicist theoretical framework to understand human development. The ecological approach to development (Developmental Ecological Psychology, DEP) places the organism at the center and has a mutualist theoretical framework with an epistemic foundation in direct perception. While research in this tradition has paid much attention to specific developmental questions at a young age (such as perceptual learning, affordances, and action coordination), less effort has gone into the discussion of theoretical issues of overall development at the level of organism-environment mutuality. Meanwhile in biology, a new emphasis on the organism as an explanatory concept and level …

Ije Table Of Contents 12(1), May 2026, Editorial Board

The International Journal of Ecopsychology (IJE)

No abstract provided.

Mapping The Rigid Landscapes Of Disordered Networks And Active Solids, Tyler Hain

Dissertations - ALL

Biological systems are able to exhibit remarkable and exotic mechanical properties by tuning their microscopic internal degrees of freedom in order to accomplish global functions. One of the most interesting mechanical behaviors of some such materials is the ability to transition between stiff solid-like states and soft fluid-like states in order to initiate specific flow patterns or tune their mechanical response. Not only this, but they are able to selectively cross this transition while also being optimized for other functions. In this dissertation I explore numerical and analytical methods for mapping the landscapes of states on the edge of rigidity …

Ecofeminist Entanglements, Rachel Benbasat

Harriet L Wilkes Honors College Theses 2020 - Present

I discuss the environmental philosophical framework known as Ecofeminism and its approaches to challenging patriarchy. The discussion includes its conceptualization of women and nature focused on women’s potential to produce life as well as conceptions of power dynamics related to the aversion of women in society and history. I discuss ecological activism associated with women and its relation to different forms of Ecofeminism. I compare Ecofeminism to other approaches to feminism and to other ecological philosophies, such as deep ecology. I conclude by sharing the present status of Ecofeminism and where it may be heading, addressing questions about how it …

Muth's Law: Anticipating Ai Model Collapse, Karl T. Muth

The University of Cincinnati Intellectual Property and Computer Law Journal

No abstract provided.