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Virus-Like Particle Peptoid Conjugate As A Triple-Negative Breast Cancer Targeting Delivery System, Ricky Zhu

Chemistry Theses

Triple-negative breast cancer (TNBC), an aggressive form of breast cancer, characterized by its lack of estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptors (HER2) poses a therapeutic challenge as common treatment options are rendered ineffective. Here is a strategy to develop a drug delivery system utilizing poly-glycinated LC129 8, a TNBC targeting peptoid, covalently attached to HK97 virus-like particles (VLP) containing a C-terminal LPETG sequence via a sortase mediated reaction. Using the properties of the cage-like structure of VLPs and the TNBC specificity of the LC129-8, high doses of chemotherapy can be efficiently loaded into the …

The Development And Evaluation Of An Automated Tactical Tillage Tool To Identify And Control Weeds In Row-Crop Production Systems Using Vision-Based Machine Learning., Clara Anne Cobb

Theses and Dissertations

Controlling in-field weeds in row-crop production systems is vital to the success of the operation. To control weeds, most producers use combinations of weed control strategies, including tillage and herbicide applications. Cotton production operations across the country have been trending toward conservation tillage practices in an effort to minimize soil disruption and maintain crop residues on the soil surface. This practice, in addition to the adoption of herbicide-tolerant cotton varieties, has encouraged more use of chemical herbicides. The overuse of these herbicides has resulted in an increase in herbicide-resistant weeds, making weed control difficult for farmers. This research aimed to …

A Woman’S Wilderness: Fostering Mental Well-Being Through Sensory Stimulation In The Outdoors, Anah Gaynes

Theses and Dissertations

The female experience with nature is unique (Nurse, G. A., Benfield, J., Bell, P. A., 2010). This provokes the question explored in this study: “What sensory interactions impact women’s mental well-being in nature-based therapy programs?” This study invited participants of nature-based retreats held at 4 Winds Farm in Glenwood Springs, Colorado or Summit Sisters at Cal-Wood Education Center in Jamestown, Colorado. Findings indicate that women’s positive emotions are significantly impacted by their sensory experiences. It also revealed a fascination with trees and the importance of tactile experiences. For landscape architects this brings about a new challenge in designing for the …

Exploring The Biological Basis For Exercise Neuroprotection In Parkinson’S Disease: A Cross-Sectional Study Of Exercise And Physical Activity On Inflammatory Cytokines And Neurotrophins, Leah Isabelle P. Alegre, Jacob M. Brewer, Adeline Florschutz, Kate E. Hamiltonthompson

UNLV Theses, Dissertations, Professional Papers, and Capstones

Regular exercise and physical therapy are known to increase production of neurotrophins, including brain-derived neurotrophic factor (BDNF), and anti-inflammatory cytokines. These changes combine to theoretically protect and slow the progressive loss of neurons in Parkinson’s disease (PD). The purpose of this study was to examine the effect of exercise and physical activity on various anti-inflammatory and pro-inflammatory cytokines and neurotrophins in people with PD (PwP). This was a cross-sectional design involving PwP (n=37), aged 43-85 years, who participated in two 30-minute bouts of exercise (with brief rest breaks during and pre/post blood draws) separated by a week. Measures collected prior …

Anatomy Academy: An Interdisciplinary Approach To Enhancing Youth Health Literacy, Roselle Antikoll, Jonathan Nakamine, Jessica Tran

UNLV Theses, Dissertations, Professional Papers, and Capstones

To enhance health literacy among the underserved youth population in Las Vegas, Nevada, Anatomy Academy (AA) is an eight-week, seven-lesson program that educates students through structured and interactive lesson plans covering basic anatomy, physiology, and nutrition. Our program was implemented in three different Title-I elementary schools between five different classrooms across Las Vegas. These lesson plans highlighted specific body systems including the cardiovascular, musculoskeletal, and gastrointestinal systems. Our primary aim was centered around involvement of more interdisciplinary healthcare professions including occupational therapy, dental medicine, osteopathic medicine, and nutrition to aid in the delivery of the AA program. Our secondary aim …

Postural And Load Dependent Modulation Of Lower Limb H-Reflex Excitability After Stroke, Daniel Bamiro, Matthew Berdiago, Ethan Hunter, Tia Nguyen

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose/Hypothesis

Leg stiffness is regulated by reflexive, intrinsic, and passive mechanisms, which are influenced by posture, body weight loading, and motor task demands. After a stroke, the capacity to modulate these mechanisms is often compromised. The H-reflex is a widely used electrophysiological tool to assess the excitability of the Ia afferent pathway within spinal circuitry. Although prior studies in healthy individuals have examined limb loading effects, results have been variable, and the role of postural and loading changes during standing remains underexplored, particularly in individuals post-stroke. This study investigated how different postural and limb loading conditions, specifically prone, standing, and …

Effect Of An Exercise Protocol On Balance In Adults With Down Syndrome, Juan Bernal, Natalie Sato

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose/Hypothesis: Down syndrome (Ds) is a complex genetic condition that can impact multiple systems of the body, including functional balance. Ds-specific impairments such as muscle hypotonia, ligamentous laxity, and decreased muscle strength, coupled with a sedentary lifestyle can result in poor motor control, altered proprioceptive function, static and dynamic instability. Visual and vestibular impairments are also common in this population, increasing fall risk and fear of falling, and discouraging participation in physical activity. The aim of this study is to analyze the impact of a physical therapy-based exercise program on the functional balance of adults with Ds.

Number of Subjects: …

Effectiveness Of Cognitive Stimulation Therapy On The Quality Of Life Of Adults With Dementia: A Secondary Analysis, Evelyn Airam

UNLV Theses, Dissertations, Professional Papers, and Capstones

This secondary analysis study evaluated the effectiveness of Cognitive Stimulation Therapy (CST) on quality of life (QoL), depressive symptoms, and cognitive function in 108 community-dwelling older adults with cognitive impairments, including dementia. Outcomes involved Quality of Life (QoL) measured by the Quality of Life in Alzheimer’s Disease (QoL-AD), symptoms of depression by the Cornell Scale for Depression in Dementia (CSDD), and cognitive function using the Saint Louis University Mental Status (SLUMS). After the CST, significant improvements were observed in QoL (p = .004), depressive symptoms (p = .002), and cognitive function (p < .001), with small effect sizes. Additionally, a significant interaction between sex and dementia diagnosis status was found in predicting cognitive changes, suggesting that the relationship between dementia diagnosis and cognitive improvement differs by sex. No between-group differences were found for QoL or depression. Findings support CST as a multidimensional, non-pharmacological intervention that improves cognitive, psychological, and social outcomes. Although effects were small, consistent improvements are clinically meaningful given the progressive nature of dementia. This study extends existing literature by demonstrating CST’s effectiveness in a community-based setting and reinforces its alignment with occupational therapy’s emphasis on participation and holistic care. Results highlight the need for early intervention and expanded access to CST programs to enhance quality of life in this population.

Unknowing Sacrifices: Public Health And Radiation Illness In New Mexico And Nevada, 1940s-1960s, Beatriz Avila-Marquez

UNLV Theses, Dissertations, Professional Papers, and Capstones

The detonation of the first atomic bomb in the early morning of July 16, 1945, in New Mexico welcomed the atomic age that forever changed the world. After that day, thousands of lives were lost due to nuclear weapons, and hundreds of thousands more continued to suffer from the effects of atomic testing. The Atomic Energy Commission, fueled by the arms race of the Cold War, chose Nevada to continue the United States’ nuclear weapons testing. Knowledge of the dangers of radiation exposure, the effects of radiation, and techniques to prevent exposure are now available in part due to the …

Fostering Adolescents’ Social-Emotional Skills In A Community Setting, Elizabeth Benitez

UNLV Theses, Dissertations, Professional Papers, and Capstones

Adolescents face growing emotional, behavioral, and social challenges, especially in community recreation settings with high energy, peer interaction, and sensory demands. These environments often expose difficulties in emotional regulation, communication, and conflict management, highlighting the need for structured social-emotional learning (SEL). This capstone project aimed to develop and implement an occupation-centered SEL program integrating the Zones of Regulation (ZOR), CASEL competencies, and Developmental, Individual Differences, Relationship-Based (DIR) Floortime principles within the Clark County Hollywood Parks and Recreation after-school program. Guided by the Person–Environment–Occupation (PEO) model, the project sought to help adolescents practice emotional awareness, self-management, and interpersonal skills in their …

Junctional Actin As A Mechanical Hub For Supracellular Actomyosin Force Transmission During Apical Constriction, Jasneet Brar

UNLV Theses, Dissertations, Professional Papers, and Capstones

Apical constriction is a conserved morphogenetic mechanism that drives epithelial folding during development. During ventral furrow formation in Drosophila melanogaster, contractile actomyosin networks generate forces that reduce apical cell area resulting in tissue invagination. For these cell-scale forces to produce coordinated tissue-scale changes, contractile networks must be mechanically integrated across neighboring cells. Although adherens junctions are known to mediate this coupling, it is unclear how junctions are integrated into cortical actin cytoskeleton, which directly determines cell, and consequently tissue, shape. This thesis tests the hypothesis that supracellular actomyosin organization during apical constriction depends on distinct adherens junction based mechanical couplings: …

Got Sleep?: The Introduction Of Sleep Hygiene To Justice Involved Individuals, Charisma Lynn Cato

UNLV Theses, Dissertations, Professional Papers, and Capstones

Individuals transitioning out of incarceration often experience challenges with sleep due to the residual effects of confinement. Although this is common among justice-involved individuals, there is limited research on how to address their sleep hygiene self-efficacy after release. Furthermore, despite the wide use of social-emotional learning (SEL) across multiple disciplines, little is known about its influence on sleep-related behavior change in re-entry populations. To address this, the Got Sleep program, designed and implemented at Hope for Prisoners (HOPE), a community site geared toward re-entry assistance, integrated occupational therapy (OT) principles and an SEL approach with practical sleep hygiene strategies to …

Inclusiveness With Sensory Maps; Enhancing Engagement In A Children's Museum, Victoria E. Davila

UNLV Theses, Dissertations, Professional Papers, and Capstones

Sensory processing challenges can affect a child’s ability to engage in play, especially when participating in community activities. When a child feels overwhelmed by sensory features in an environment, such as noise or bright lights in a community space, they may experience sensory overload. Caregivers often observe this behavior but may not have access to resources to help their child navigate these challenges. This capstone project aimed to implement a program development initiative at the Discovery Children’s Museum focused on developing sensory-inclusive resources for caregivers visiting the museum with a child. The role of occupational therapy in this project is …

Interpretable Deep Learning Models For Trustworthy Prediction Of Enzyme Functions, Louis Dumontet

UNLV Theses, Dissertations, Professional Papers, and Capstones

Trustworthy prediction of enzyme function from protein sequences remains a central challenge in computational biology, particularly when annotated data are limited, imbalanced, or incomplete. This dissertation develops interpretable deep learning methods for enzyme discovery and enzyme function prediction from amino acid sequences. First, it introduces PEPIC, an interpretable convolutional neural network for substrate-level prediction of hydrolytic plastic-degrading enzymes. Using curated and expanded sequence datasets, PEPIC improved predictive performance over benchmark methods, identified sequence regions aligned with catalytic and substrate-binding residues, and supported the discovery and experimental validation of a previously uncharacterized PET-degrading enzyme. Second, this dissertation investigates the integration of …

The Lotus Project: An Occupation-Based Online Module To Support Healthy Matrescence, Virginia Genato

UNLV Theses, Dissertations, Professional Papers, and Capstones

Becoming a mother is a meaningful life event that occurs amid complex physical, psychological, and social changes. During this period, individuals undergo an occupational role transition as they assume new caregiver responsibilities while navigating contextual demands. The ease of this transition influences overall maternal adjustment. The dominant sociocultural model of intensive mothering promotes child-centered caregiving, often at the expense of maternal well-being and adjustment. Efforts to meet these expectations may disrupt an individual’s transition into motherhood and place them at risk for developing postpartum mental health challenges.

The concept of matrescence provides a developmental framework that views motherhood as an …

Establishing A Comprehensive Framework For Sfrt Lattice Treatments: Optimization, Planning, And Clinical Evaluation, Gregory M. Gill

UNLV Theses, Dissertations, Professional Papers, and Capstones

Spatially fractionated radiation therapy (SFRT) using lattice radiotherapy (LRT) has emerged as a promising treatment technique for bulky, nonresectable tumors by delivering spatially heterogeneous dose distributions consisting of high-dose vertices embedded within lower-dose regions. Although early clinical experiences have demonstrated potential therapeutic benefit, widespread clinical implementation of LRT remains limited due to the absence of standardized treatment planning workflows, consistent optimization strategies, and clearly defined evaluation metrics for heterogeneous dose distributions. The objective of this study is to develop and evaluate a structured framework to support efficient, reproducible, and safe clinical implementation of LRT.

To address these challenges, a comprehensive …

"Home Means Nevada": Latinx Belonging In A New Destination, Maria G. Hermosillo

UNLV Theses, Dissertations, Professional Papers, and Capstones

This project examines how Latinx individuals construct meanings of home and belonging in a Southern Nevada micropolitan city. Nevada is considered a new “Hispanic settlement state” and “New Immigrant Destination” as the state has experienced significant Latinx population growth since the 1990s. This research addresses an empirical gap by centering Nevada in understanding Latinxs lived experiences through the taken-for-granted concept of “home” and a theoretical gap by advancing New Destinations research where moral order, economy, and region influence ethnic incorporation.

Drawing on 32 in-depth semi-structured interviews with current and former Latinx residents and supplemented by participant observation, the study analyzes …

Feasibility Of High-Intensity Training (Hit) For Academic Engagement In Young Adult Women, Raleah Tenorio Kastner

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose: This feasibility study aimed to identify the impact of a high-intensity training (HIT) exercise protocol on healthy behaviors related to academics to decrease stress levels and enhance academic engagement and overall quality of life in young adult female students, measured by a modified version of the National Survey of Student Engagement (NSSE) and the Occupational Experience Profile (OEP).

Methodology: One young adult female student enrolled at UNLV who is 18-25 years old was recruited via convenience sampling to engage in a 12-session HIT exercise program, developed by a certified personal trainer and licensed occupational therapist, with the participant’s target …

A Tale Of Two Mammals: Tenrec Ecaudatus And Homo Sapiens, Debra Renee Kerr

UNLV Theses, Dissertations, Professional Papers, and Capstones

Most modern mammals maintain stable body temperatures (Tb) ~37ºC and high metabolic rates. Hibernators, like ground squirrels, are homeothermic during the active summer season, but are heterothermic during the hibernation season. During the hibernation season, ground squirrels follow a predictable pattern of torpor bouts interrupted by interbout arousals. Tenrecs are unusual because they are heterothermic and heterometabolic even during the active season. Previously, ground squirrel bile constituents were shown to be predictive of whether a squirrel is in the summer active or winter hibernation season. We found tenrec bile constituents were highly variable and not predictive of seasonal and metabolic …

Impairment And Disability In Mesoamerica: Bioarchaeological Evaluation And Interpretation Of The Maya Of Palenque, Dayanira Lopez

UNLV Theses, Dissertations, Professional Papers, and Capstones

The application of disability theory to the past is of growing interest among bioarchaeologists, both nationally and internationally. However, its application poses greater challenges when considering ancient contexts, such as Mesoamerica. Nonetheless, engagement with disability studies has led to the development of various theoretical frameworks in bioarchaeology, including dis/ability. This model views physical impairment as a fluid state that may exhibit adaptability and resilience rather than a biological deficit. Importantly, it views ability on a spectrum and does not make assumptions about social and cultural perceptions of ability where there is a lack of contextual data. Thus, it is a …

Exploring The Impacts Of Contextualized Learning In An Engineering-Specific Corequisite Precalculus Course On Student Achievement, Motivation, And Belongingness, Amy Mathis-Leonard

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study examines the design and implementation of a contextualized engineering-specific corequisite Precalculus I course and its impacts on student achievement, motivation, and sense of belonging. This study was conducted in response to decreasing national rates of mathematical readiness, the elimination of stand-alone developmental mathematics courses across multiple states and systems, and the demand for research related to effective corequisite models in mathematics coursework. The intervention created an experimental section of corequisite Precalculus I in which all the students were engineering majors who did not demonstrate readiness for a college-level precalculus course. Unit lessons incorporated engineering-specific topics and career-oriented discussions. …

A Comparison Of Changes In Vertical Cephalometric Measurements In Patients Treated With Invisalign And Traditional Fixed Orthodontic Appliances: A Retrospective Study, Shayna Mesko

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: Since their introduction into the field, clear aligners have significantly grown in popularity in orthodontics as they offer enhanced esthetics, improved oral hygiene, and patient comfort. Clear aligners have allowed clinicians to simulate treatment outcomes, streamline treatment with reduced office visits, control force and movement per tray, and provide more precise control of focal tooth movements. This can enhance efficiency in achieving specific and very finite orthodontic goals. Since their inception, clear aligners have evolved from only accomplishing simple tooth movements to achieving more complex and comprehensive mechanics. While they have significantly advanced, there are still limitations in efficacy …

Addressing Sleep Health In The Fire Service: A Sleep Hygiene Education Program, Alyssa Elizabeth Neal

UNLV Theses, Dissertations, Professional Papers, and Capstones

This capstone project implemented an occupational therapy sleep hygiene program tailored to the unique occupational demands of Las Vegas Fire and Rescue (LVFR) firefighters. Guided by the Occupational Adaptation theory and the CALMS Framework, this project conceptualized sleep as a meaningful occupation essential to health, safety, and functional performance. The project’s aim was to assess the feasibility of a sleep hygiene program designed for the fire service using standardized measures, including the Sleep Hygiene Index. The methodology incorporated a structured educational session focused on educating firefighters on the importance of sleep, modifying routines and environments to support restorative sleep, implementing …

Correlation Between Maxillary Sinus Volume And Maxillomandibular Size, Position, And Dental Occlusion: A Cbct Retrospective Study, Philip Villanueva Punzalan

UNLV Theses, Dissertations, Professional Papers, and Capstones

This investigation used cone beam computed tomography (CBCT) based three dimensional imaging to evaluate correlations between maxillary sinus volume and maxillomandibular skeletal size, position, and dental occlusion in an adult orthodontic population. A retrospective sample of 107 pretreatment CBCT scans (40 males and 67 females), aged 18–59 years, was analyzed. Right and left maxillary sinuses were segmented independently using semi-automatic volumetric segmentation in ITK-SNAP software, and total sinus volume was calculated in cubic millimeters (mm³). Linear and angular skeletal measurements of the maxilla and mandible were obtained using Anatomage TxSTUDIOViewer application software. Patients were categorized according to anteroposterior (A-P) skeletal …

Methylation-Dependent Regulatory Pathway That Governs The Stability Of The Sox Family Proteins And Related Developmental Regulators, Keshari Gayathri Rajawasam

UNLV Theses, Dissertations, Professional Papers, and Capstones

The SRY (Sex-determining Region Y) protein is a transcription factor encoded on the Y chromosome and is the key regulator responsible for initiating male sex determination in mammals. During early embryonic development, SRY activates the genetic program that leads to testis formation by promoting the expression of downstream genes involved in male gonadal differentiation. Mutations or dysregulation of SRY can lead to disorders of sex development such as male-to-female sex conversion and hermaphroditism, highlighting its critical role in sex determination.

SRY belongs to the SOX (SRY-related HMG-box) family of transcription factors, which includes the proteins SOX1, SOX2 and SOX3. These …

Who Am I As An Elementary Cs Teacher? The Identity Development And Struggles Of Elementary Teachers As Computer Science Teachers, Burak Sahin

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study investigates how elementary teachers develop and negotiate their identities as computer science (CS) teachers within the expanding presence of CS in early K–12 education. As CS is increasingly integrated into early grades, many teachers are expected to teach it without formal preparation. It positions them to simultaneously learn, teach, and construct a professional identity in an unfamiliar domain. Using an interpretive phenomenological approach, this study examines teachers’ lived experiences of identity development by drawing on identity theory (Gee, 2000) and the performance, recognition, and competence framework (Carlone & Johnson,2007) to understand how identity is shaped through practice, institutional …

Examining The Relationships Among Collaborative Teaching Practices, Self-Efficacy, And Teachers' Self-Regulation In Charter School Culture, Melissa J. Seltenreich

UNLV Theses, Dissertations, Professional Papers, and Capstones

This dissertation examined the relationships among collaborative teaching practices, teacher selfefficacy, and self-regulation among 226 in-service K–12 teachers in Southern Nevada public charter schools. Teaching is a demanding profession that requires strong self-regulation (goal setting, monitoring, reflection, and adaptive strategies) and self-efficacy to sustain effective instruction, teacher well-being, and professional longevity. Collaborative teaching practices, which emphasize teamwork, shared planning, and peer support, were hypothesized to strengthen these psychological capacities within charter environments characterized by high autonomy and accountability. This research study focuses on 3 questions including demographic and situational variables that contribute to differences in teachers’ self-regulation, teachers with higher …

Is Forgetting Independent Of Learning? An Examination Of Initial Learning Across Alternative Forgetting Analyses, Rhiannon Nicole Soriano Smith

UNLV Theses, Dissertations, Professional Papers, and Capstones

A long-standing debate has reappeared regarding whether the rate of forgetting is independent or dependent upon the initial degree of learning. Interestingly, both conclusions have been supported. These diverging conclusions could be due to the analytical method and operational definition of forgetting employed: Researchers supporting independence typically measure forgetting as the number of items forgotten at a given retention interval, while those in favor of dependence typically measure forgetting as the number of items forgotten between test intervals. The current study tested whether the degree of learning affects the rate of forgetting for recognition accuracy (da) and other memory processes …

Exploring Non-Native English Learners’ Attitudes Towards Ai And Online Multimedia Persuasive Opinions And The Role Of Sentiment, Zvetomira N. Svetleff

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study and various other studies use quantitative models to identify which persuasive features predict persuasiveness. Most studies in the field do not explain why participants responded as they did nor do they focus on studying adult non-native English learners also referred to as second language (L2) English learners. Despite seemingly remarkable progress on research related to how to convey persuasive messages, there has been little work related to persuasive messaging targeted at second language learners or non-native speakers. In addition, despite the increasing reliance on AI technologies and tools in language learning within educational and work settings, there has …

Negro Spirituals: The Long Journey West, Lavell Thompson, Jr.

UNLV Theses, Dissertations, Professional Papers, and Capstones

This text seeks to explore the origins of Negro spirituals, and how they evolved, highlighting their arrival to Las Vegas, Nevada. It outlines the primacy of vocal music, particularly in reference to African American spirituals, and how they were shaped via the influence of African and European traditions. As it is impossible to address every type of spiritual created, the text focuses on a few types of spirituals—namely joyous accounts and spirituals that use codes for messages. Moreover, it seeks to create a comprehensive understanding of the origins of Las Vegas, because without acknowledging the contributions of the Mormon Church, …