Digital Commons Network^™

Transcranial Ac Modulation Of Cerebellar Nuclear Activity In Awake Animals, Nuran Kavakli

Dissertations

Entrainment of cerebellar nuclear (CN) cells via cerebellar transcranial alternating current stimulation (ctACS) has been reported in animals under ketamine/xylazine anesthesia. Our main objective was to demonstrate modulation of CN activity in unanesthetized, freely moving animals using ctACS. Multi-channel carbon-fiber electrodes were implanted into the interpositus nucleus for recording multi-unit (MU) activity, and thin-film electrodes were implanted subcutaneously over the posterior cerebellum for stimulation. A frequency-domain-based metric was developed to quantify modulation from MU signals. The results demonstrated modulation in a wide range of frequencies (4 Hz-300 Hz) as in anesthetized animals. In contrast, the amplitude of the peak in …

Enhancing Physiological Complexity Through Mindfulness: A Wearable-Based Intervention For First Responders And Their Partners, Thurmon Lockhart, Rahul Soangra, Christopher W. Frames, Sun-Kyung Lee, Amberlee Martin, Susanne Lee, Abigail H. Gewirtz

Physical Therapy Faculty Articles and Research

Background/Objectives: First responders frequently encounter high-stress environments that challenge physiological resilience and autonomic regulation. Heart rate variability (HRV) complexity is a critical marker of adaptive capacity and stress regulation. This study assessed the impact of a wearable-based mindfulness intervention on HRV complexity among first responders using a smartwatch. Methods: A total of 87 first responders participated in a one-month wearable-based intervention. Participants wore Garmin Vivosmart 5 devices to continuously collect PPG data (photoplethysmogram), focusing on beat-to-beat intervals (BBIs). The intervention involved daily Ecological Momentary Assessments (EMAs) and individual randomization to either a mindfulness message, a prompt to access an audio …

Electrospun Nanofiber Scaffolds For In Vitro 3d Tissue Engineering, Victoria E. Santillan, Samerender Nagam Hanumantharao, Stephanie Bule, Ronish M. Shrestha, Carter Rodzik, Alan Mendoza Estrada, Stephen L. Farias, Marina Tanasova, Smitha Rao

Michigan Tech Publications

Tissue engineering is widely used in research for investigating cellular proliferation, behavior, and responses to various stimuli. However, the predictive value of preclinical studies using cell culture plates is limited by the inability to recapitulate the complexity of the physiological microenvironment. Synthetic three-dimensional (3D) scaffolds can be engineered to mimic the complex morphology of the extracellular matrix of native tissues and can serve as physiologically relevant platforms for preclinical studies. In this study, 3D electrospun scaffolds were characterized to aid in breast cancer research. Unlike previous studies that focused primarily on scaffold fabrication or cell viability, this work systematically evaluates …

Culturally Competent Nurse-Led Education To Reduce Delayed Diagnosis And Increase Awareness Of Polycystic Ovary Syndrome In Reproductive-Aged South Asian Women, Madeeha Syeda

Honors College Theses

Polycystic ovary syndrome (PCOS) is a common condition that affects hormones in women, especially in their 20s and 30s. Symptoms of PCOS include irregular periods, abnormal hair growth, acne, obesity, hyperpigmentation of the skin, cysts, skin tags, thinning hair, and infertility (Newin, 2023). While the exact cause of PCOS is unknown, it is linked to insulin resistance, higher levels of androgens, and low-grade inflammation (Newin, 2023). In regards to complications, PCOS can increase risk for gestational diabetes, preeclampsia, preterm term, and C-section deliveries. In terms of treatment, there is no cure but early diagnosis is key to reducing symptoms (Newin, …

Evaluation Of Medical Instrument Reliability For The Heath And Maddox Components Of The Accommodative-Vergence System, Jacob Chabuel

Theses

Binocular vision relies on the coordination of near response triad composed in part by the vergence and accommodative systems. Binocular dysfunctions linked to these systems impact the quality of life of those affected by complicating day-to-day tasks and leading to further health concerns. Clinical evaluations that diagnose dysfunctions and tailor therapies rely on subjective methods, creating a need for a reliable, quantitative, measurement tool. This is achieved using a haploscope, a tool that quantitatively measures and observes binocular vision to identify deficiencies within the eye. Modernization of a haploscope system, measurement of the Heath and Maddox components of the visual …

Developing The Evidence And Associated Service Models To Support Older People Living With Frailty To Manage Their Pain And To Reduce Its Impact On Their Lives: A Mixed Method, Co-Design Study (The Poppy Study).: The Poppy Study, Lesley Brown, Deborah Antcliff, Andrew Clegg, Anne Grice, Pat Schofield, Asim Suleman, Amanda Williams, Nikki Harrison, Nicky Kime, Alan Wright, Natalie Lam, Dan Howdon, Davide Tebaldi, Rahena Mossabir, Sarah Hallas, Thomas F Crocker, Anne Forster

School of Nursing and Midwifery

Background: Frailty increases vulnerability to adverse events (falls, illness) resulting in poorer health outcomes in later life. Persistent pain is common and impactful in older adults with frailty. Pain impact is potentially modifiable, and addressing it is important for supporting this population. The Pain in Older People with Frailty study aimed to generate evidence and develop service models to improve pain management for older adults with frailty and inform service provision for this underserved population. Objective(s): Phase 1: Map research evidence and synthesise findings from randomised controlled trials of multi-component pain management programmes and psychological therapies for community-dwelling older adults. …

Investigation Of Environmental Influences On Multiple Sclerosis: A Study For Egypt’S Health, Noha Ezzaldin Alziny Ali

Theses and Dissertations

Background: Multiple sclerosis (MS) is a complex, chronic neuroinflammatory disease influenced by both genetic and environmental factors. While global research has identified potential environmental influences, most evidence comes from Western populations, creating a significant knowledge gap for regions like Egypt, which has witnessed a dramatic rise in MS prevalence over recent decades. This study hypothesized that Egyptian MS patients exhibit a distinct biological signature in their blood, characterized by an imbalance in essential and toxic trace elements (the metallome) and alterations in stress-response biomarkers associated with neuroaxonal injury and cellular stress. Objective: This study aimed to comprehensively profile and compare …

Empowering Healing And Recovery: Adverse Childhood Experiences Screening In A Cognitive Behavioral Therapy Intensive Outpatient Program, Serena C. Lee

Doctor of Nursing Practice Final Manuscripts

Purpose: This evidence-based practice project implemented Adverse Childhood Experiences (ACEs) screening in an adult Cognitive Behavioral Therapy Intensive Outpatient Program (COG IOP) at San Diego's largest behavioral health hospital to identify ACE exposure, deliver supportive interventions, and enhance clinician competency in trauma-informed care.

Background: ACEs are potentially traumatic experiences occurring before age 18 that are associated with toxic stress and worsening health outcomes. Despite evidence linking ACEs to adverse outcomes and substantial healthcare costs, routine ACE screening is not standardized in behavioral health settings.

Methods: Guided by the San Diego 8A's Evidence-Based Practice model, eligible patients were offered ACEs screening …

Enhancing Tardive Dyskinesia Screening In An Outpatient Psychiatry Training Clinic: A Quality Improvement Initiative, Ariel Davalos

Doctor of Nursing Practice Final Manuscripts

Background: Tardive Dyskinesia (TD) is a debilitating, often irreversible movement disorder caused by prolonged exposure to dopamine receptor-blocking agents, affecting 15-30% of patients on long-term antipsychotic therapy. Despite endorsement of the Abnormal Involuntary Movement Scale (AIMS) as the gold standard for TD screening, the condition remains significantly under-diagnosed. Purpose: This quality improvement project evaluated whether a 45-minute educational intervention could improve PMHNP trainees’ confidence and competence in TD recognition and AIMS administration. Methods: Guided by the Iowa Model of Evidence-Based Practice, the project used a pre-post survey design with a planned one-month follow-up across two clinical training sessions. Ten PMHNP …

Trends Of Pediatric Psychotropic Polypharmacy In Massachusetts Before And During The Covid-19 Pandemic, Gianna D'Ambrozio

Graduate Doctoral Dissertations

Youth in the U.S. and internationally are increasingly being diagnosed with depression and related psychiatric conditions (Murthy, 2021) many of whom are being subjected to non-evidence-based, or what has been termed irrational, psychotropic polypharmacy (Barnett & Concepcion Zayas, 2019). Psychotropic polypharmacy can be defined as “the use of 2 or more psychiatric medications in the same patient,” (Zito et al., 2021) though definitions can vary. Using data from the Center for Health Information Analysis’ Massachusetts All-Payer Claims Database, this study examined the sociodemographic factors associated with high rates of polypharmacy, a hypothesized increase in pediatric psychotropic polypharmacy rates in Massachusetts …

Pickleweed In The Disappearing Marsh: Population Genetics & Metal Accumulation In Salicornia Depressa, Alice Kaisla

Graduate Doctoral Dissertations

Salicornia is a genus of succulent halophytes found in salt marshes around the world. Salicornia species have a remarkably high tolerance for heavy metal pollution and have been shown to accumulate high concentrations of heavy metals in their tissue under experimental conditions. As a result, they are both a useful system for studying evolution in polluted coastlines and a potential candidate for use in phytoremediation. My research focuses on Salicornia depressa, known as pickleweed, a species commonly found in marshes along the heavily urbanized and industrialized New England coast. I investigate genetic diversity and population structure in S. depressa populations …

Streamlined Biomedical Image Processing Pipelines, Jiehyun Kim

Graduate Doctoral Dissertations

This dissertation focuses on advancing carotid artery analysis through a series of visualizations and deep learning tools for calcified plaque assessment and related biomedical imaging tasks. Accurate plaque evaluation is essential, but current workflows depend on slow, clinician-dependent manual review. To address these limitations, this work introduces the CACTAS framework, a set of tools and methods that enable fast and reliable plaque segmentation for clinicians.

The first study, the CACTAS-Tool, provides a web-based labeling tool that enables clinicians to label plaque directly in three dimensions through a streamlined one-click interface. This tool significantly reduces the effort required to generate high-quality …

Adapting Population Genetics, Practice, And Policy For Plant Conservation In A Changing World, Cooper M. Kimball-Rhines

Graduate Doctoral Dissertations

Biodiversity conservation is an inherently interdisciplinary goal that requires effective collaboration among academics, ecosystem managers, policymakers, and other stakeholders. Codesigning research with these groups ensures experiments are useful and improves adoption of policy and practice recommendations while advancing our understanding of basic science. This dissertation explores the power of codesigned research in shaping plant conservation strategies using stakeholder engagement, causal inference, demographic modeling, and multi-omic sequencing techniques. In chapter 1 I discuss the history of New England ecosystems and the need for research-driven changes to plant conservation policy and practice in the face of global change. In chapter 2, I …

Static Data-Race Detection For Gpu Programs: Behavioral Types With Partial Completeness Guarantees, Zhen Rong Liew

Graduate Doctoral Dissertations

GPUs are essential to modern computing but notoriously difficult to program correctly. Static analysis tools can verify data-race freedom, but their over-approximations produce spurious reports of data races that do not occur, limiting their practical usefulness. This dissertation establishes when Memory Access Protocols (MAPs), a compositional abstraction modeling memory access behavior between synchronization barriers, can be simultaneously sound and complete. We first prove that MAP-based analysis is sound and complete for well-typed Jaminan programs---those without data-dependent array indexing. This result establishes the theoretical boundary: completeness is achievable when data-dependent control flow and indexing are absent. Jaminan extends MAPs with symbolic …

Talk To Me: Exploring The Sociocultural Ecology Of Home Language And Literacy Practices Of Families In India, Surbhi Puri

Graduate Doctoral Dissertations

Existing research highlights the role of home language and literacy environments (HLLE) in shaping early language and literacy development, yet few studies have examined the practices of multilingual families in India. While home environments offer rich learning opportunities, broader sociocultural and policy contexts influence how families support literacy and language development. Families’ insights into home language use, literacy routines, and cultural practices remain underexplored in early childhood education research.

The purpose of this qualitative multiple case study was to explore the HLLE of preschool-aged children in India and examine how families support early language and literacy development within multilingual home …

Small Molecule Antioxidants As Potential Therapeutics For Preeclampsia, Maxim Mastyugin

Graduate Doctoral Dissertations

The major goal of this work was to develop a therapeutic intervention against preeclampsia (PE). Preeclampsia affects up to 5-7% of all pregnancies and has no causative treatments. It is associated with oxidative stress caused by a prolonged ischemic state and increase in reactive oxygen species (ROS) in the placenta. The cardinal symptoms include high blood pressure, kidney dysfunction, and in severe cases, eclampsia. With no treatment for the underlying causes available, we offer small molecule antioxidants which may scavenge ROS in the placenta arising from the initiating event of PE, the oxidative stress. By reducing placental ROS, these antioxidants …

Computer-Aided Development Of Novel Antioxidants, Rita Bernadett Vlocsko

Graduate Doctoral Dissertations

Physiological redox homeostasis is a fine balance between prooxidants and antioxidants that are integrated elements of several reduction-oxidation mechanisms at molecular, organellar, cellular and tissue levels. When this equilibrium is disrupted and prooxidants become dominant, the body relies on endogenous and exogenous antioxidants to counterbalance the dysregulation and ultimately prevent the progression of oxidative stress. Reactive species (reactive oxygen species, reactive nitrogen species, or reactive sulfur species) are significant contributors to prooxidant activity. Over the years, substantial knowledge has been accumulated regarding their origin and roles in disease development, leading to the discovery and development of antioxidants that effectively target …

Rethinking Flow: The Paradox Of Renoprotection Without Increased Renal Blood Flow In Cardiopulmonary Bypass, Shiksha Mohan, Ronald A Shaju, Sharan Misra, Titiksha Sharma, Veeraj K Sirivolu, Abhinav Rajkumar, Anthony Rodas-Camacho, Aizah Zaidi, Dhruv Dhingra, Ilma Khan, Rishav Bhattacharya, Vishal Pancholy, Shivam Banerjee, Shreyo Ghosh, Shiyi Li, Kenneth K Liao, Carl P Walther, Nandan K Mondal

Faculty, Staff and Students Publications

No abstract provided.

Perinatal Mental Health Screening And Care Among Those With Pregnancy Complications, Alison N Goulding, Terri L Fletcher, Emily S Miller

Faculty, Staff and Students Publications

Perinatal mental health conditions are common and, without effective treatment, can contribute to adverse maternal and child outcomes. In the United States, mental health conditions are a leading cause of maternal morbidity and mortality, contributing to over 20% of pregnancy-related deaths. This expert review aims to assess current literature and provide recommendations regarding mental health care in high-risk patients who experience pregnancy complications. Individuals experiencing pregnancy complications are at increased risk for perinatal mental health conditions, including depression, anxiety, and post-traumatic stress disorder, as compared to those with uncomplicated pregnancies. Despite this increased disease burden, there is limited research on …

Xanthogranulomatous Osteomyelitis As A Bone Tumor Mimic: A Systematic Review Of Pre-Biopsy Diagnostic Clues And Management Decision Points, Ethan J. Sack, Max Deneroff, Austin Khau, Zubair Mohammed, Chadi Ellaham, Jared Nichols

Student Publications

Xanthogranulomatous osteomyelitis (XO) is a rare inflammatory form of osteomyelitis that can closely resemble a primary bone tumor or metastatic lesion at presentation. This systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and focused on pre-biopsy diagnostic clues and management decision points in published skeletal XO reports. PubMed, Embase, and Scopus were searched from January 2026 to May 2026, identifying 86 records. Eligible studies included human case reports and case series describing histologically confirmed skeletal XO or xanthogranulomatous inflammation involving bone; non-skeletal xanthogranulomatous disease, duplicate reports, review articles without extractable patient-level …

Pernicious Anemia Presenting As Pseudothrombotic Microangiopathy: A Case Report, Sai Sushrutha M Vemula, Shreeya Adhikari, Shreya Motkur, Alfarooq Alshaikhli, Borys Hrinczenko

School of Medicine Publications

Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and end-organ dysfunction, with high untreated mortality that can be effectively reduced with timely plasma exchange (PLEX) and immunosuppressive therapy. However, several conditions can produce a clinically similar pseudo-TMA picture, among which severe vitamin B12 deficiency is an underrecognized and potentially treatable mimic that occurs due to ineffective intramedullary erythropoiesis, megaloblastic fragmentation of structurally abnormal erythrocytes, and pancytopenia in the absence of true endothelial injury or ADAMTS13 deficiency. We present a 74-year-old female patient who presented with altered mental status, bradycardia, and severe …

Developing The Evidence And Associated Service Models To Improve Pain Management In Older People Living With Frailty: A Synopsis Of The Poppy Mixed Method, Co-Design Study: Poppy, Patricia Schofield

School of Nursing and Midwifery

Background: Frailty increases vulnerability to adverse events (falls, illness) resulting in poorer health outcomes in later life. Persistent pain is common and impactful in older adults with frailty. Pain impact is potentially modifiable, and addressing it is important for supporting this population. The Pain in Older People with Frailty study aimed to generate evidence and develop service models to improve pain management for older adults with frailty and inform service provision for this underserved population. Objective(s): Phase 1: Map research evidence and synthesise findings from randomised controlled trials of multi-component pain management programmes and psychological therapies for community-dwelling older adults. …

Makna Simbolik Dan Memori Pascakolonial Dalam Cyanotype Fusion Dialogue “Trade Of Faith” Karya Budi Agung Kuswara: Kajian Semiotika Roland Barthes, Wisesa Abrar Mufid Munawwar Wahyuono, A. Syarifuddin Rohman

Journal of Language, Literature, and Arts

The cyanotype artwork Fusion Dialogue: Trade of Faith by Budi Agung Kuswara represents a contemporary art practice that combines cyanotype techniques and mixed media to construct visual narratives of colonialism, trade, spirituality, and cultural identity. This study aims to identify the visual symbols embedded in the artwork and analyze their meanings based on Roland Barthes’ semiotic theory. A descriptive qualitative approach was employed, with the researcher serving as the primary instrument. Data were collected through observation, documentation, interviews with the artist, and a literature review. Analysis involved symbol identification as well as denotative, connotative, mythological, and aesthetic analyses. The findings …

Civil Liability Arising From Damages Resulting From The Use Of Artificial Intelligence In The Profession Of Robotic Medicine, Hisham Jadallah Mansour Shakaterh, Dr. Ahmed Bin Saleh Bin Nasser Al-Barwani

AUIQ Humanities and Social Sciences

Civil liability for damages arising from the use of artificial intelligence in the practice of robotic medicine is considered a modern topic of significant importance across various countries worldwide, particularly in the United Arab Emirates, which is well known for its progress in all sectors, especially the healthcare sector. The adoption of artificial intelligence in this field aims to employ advanced technologies to enhance the quality of medical services and provide sophisticated healthcare to the community. The importance of this study lies in highlighting the role of artificial intelligence in the practice of robotic medicine, with a focus on the …

Making Kinship With Plants And The Multiple Meanings Of Care In Amazonian Indigenous Gardens, Ana Gabriela Morim De Lima

Tipití: Journal of the Society for the Anthropology of Lowland South America

This paper focuses on the bonds of kinship and care between humans, cultivated plants, and other-than-human beings in Indigenous gardens, myths, rituals, and shamanism, across Lowland South America. Drawing on Krahô ethnography and a review of ethnological literature, it highlights the contributions of Americanist ethnology to wider debates about multispecies relation, particularly with regard to vegetal agency. By exploring the ambivalent meanings of care- such as “caring,” “raising,” and “nurturing,” as well as “being careful,” “having respect,” and “taking precautions”- I examine how kinship relations between humans and their cultivated plants are made through care and unmade through its absence …

Is Trimethylamine N-Oxide A Friend, Foe, Or Hormetic Agent In Patients With Parkinson’S Disease: A Focused Review Of One Microbial Metabolite, Abraham B. Alton

Student Works

This review synthesizes recent literature examining trimethylamine N-oxide (TMAO) synthesis and its potential role in Parkinson’s Disease (PD) pathology. An increase in TMAO plasma and CSF concentration is associated with PD progression and severity. TMAO biosynthesis is a two-step process. First, precursors including carnitine and choline are converted to trimethylamine (TMA) by gut microbes. Second, TMAO is oxidized to TMAO in the liver. Once absorbed into circulation TMAO crosses the blood brain barrier and may influence PD disease pathology by increasing neuroinflammation and astrocyte activation and damaging the cerebral lymphatic system. These mechanisms may contribute to the cognitive and motor …

On The Brink Of Silence: Ethnographic Perspectives On Hunting And Forest Life Among The Awa Guajá In Eastern Amazonia, Uirá Garcia

Tipití: Journal of the Society for the Anthropology of Lowland South America

The central theme of this article basically resides in the relationship established by indigenous peoples between their hunting practices and the forest. Indigenous ways of connecting ‘hunting’ and ‘forest’ necessarily pass through other modes of knowing, only marginally – if it all – dependent on vision. On the contrary, sounds, smells and even dreams are, for many South American indigenous collectives, more trustworthy indices than what the eye sees. This article divides into two parts. In the first, I set out the main ideas related to the anthropological study of hunting in Amazonia at a conceptual level. In the second, …

A Call To Action: Towards A Compendium For Culturally Responsive And Inclusive Pain Management, Arvie Vitente, Rob Sweet, Lester Jones

Philippine Journal of Physical Therapy

Introduction: Pain is a pervasive global health problem, yet its assessment and management remain shaped by biomedical, monolingual, and culturally narrow assumptions that do not fully reflect the lived realities of diverse populations. Although contemporary pain science recognizes pain as a personal experience influenced by biological, psychological, and social factors, inequities persist across racial, ethnic, linguistic, and cultural groups.

Main Body: These inequities affect how pain is expressed, interpreted, documented, and treated, particularly among Indigenous peoples, migrants, refugees, and patients with limited English proficiency. In this perspective, we call for the development of a comprehensive compendium on culturally responsive and …

Self-Reported Gum Bleeding, Oral Health Behaviors, And Cardiovascular Risk Indicators Among Adults Aged 45-70 In A Community Dental Setting., Kimberleigh Edwards

Population Health Leadership and Analytics Theses

Cardiovascular disease remains a leading cause of morbidity and mortality among adults in the United States, particularly during midlife and older adulthood. Periodontal inflammation and poor oral hygiene behaviors have been linked to increased cardiovascular risk through systemic inflammatory pathways. This exploratory cross-sectional study described patterns of self reported gum bleeding, oral hygiene behaviors, and cardiovascular risk factors among 29 adults aged 45 to 70 at a community dental clinic using the researcher-developed Oral and Heart Health Study Questionnaire. Fourteen participants reported both gum bleeding and at least one cardiovascular risk factor. Participants who reported inconsistent flossing and infrequent professional …

Customary Forest Management Based On Cultural Spatial Tripartite Scheme In Tenganan Pegringsingan, Aloysius Gonzaga Dimas Bintarta Raharja, M. Baiquni, S. Setiadi

Forest and Society

The customary forest of Tenganan Pegringsingan in Karangasem, Bali, received the Customary Forest Decree from the Ministry of Environment and Forestry in 2019 as a part of Social Forestry implementation. This decree marked the beginning of granting rights to manage the customary forest for the traditional village in Bali. The Tenganan Pegringsingan indigenous community manages their customary forest through a traditional bureaucratic scheme, employing the authority of Krama Desa and a set of customary laws (awig-awig). Krama Desa acts as the governance authority for the utilization of the Tenganan Pegringsingan customary forest, involving two parties: the inheritance rights …