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Articles 4981 - 5010 of 18734
Full-Text Articles in Entire DC Network
Between Untouchability And Slavery: Dewey, Russell And Ambedkar On Freedom-As-Growth, Danish Hamid
Between Untouchability And Slavery: Dewey, Russell And Ambedkar On Freedom-As-Growth, Danish Hamid
Dewey Studies
No abstract provided.
Exploring The Effects Of Pest-Induced Hemlock Mortality On Growth In Neighboring Trees, Sidney L. Booher
Exploring The Effects Of Pest-Induced Hemlock Mortality On Growth In Neighboring Trees, Sidney L. Booher
McNair Culminating Research Projects
Trees provide many important products and services to humans. In particular, tree growth is critical to carbon storage, air and water quality, and helps determine demographic processes like population growth and reproductive success. Importantly, tree growth is sensitive to both abiotic (environmental) and biotic factors and is vulnerable to ecological disturbances. Understanding how tree populations respond to disturbances, like invasive pests, is therefore crucial to formulating timely and effective forest management practices.
Here, I used tree ring analysis to investigate how competition for water between neighboring trees changes following the decline of Eastern and Carolina Hemlock(ECH) trees due to the …
Exploring The Therapeutic Potential Of Kinetin In Allergic Contact Dermatitis, Hamna Muzaffar
Exploring The Therapeutic Potential Of Kinetin In Allergic Contact Dermatitis, Hamna Muzaffar
Thesis/ Dissertation Defenses
Allergic contact dermatitis is T cell mediated inflammatory skin disorder commonly studied using contact hypersensitivity mouse model. It induces local inflammation and further evidence suggests that gut microbiome also contributes to disease progression. However, kinetin, a natural plant hormone modulates these immune processes. After TNCB successfully induces CHS, kinetin treatment resulted in significant reduction in serum IgE levels while its effect on ear swelling and histological changes were modest. Microbiome analysis revealed no major difference in alpha diversity instead beta diversity demonstrated increased microbial heterogeneity in TNCB-treated mice group. Conversely, Kinetin-treated groups exhibited a microbial profile similar to wild type …
Comparative Study Of Alginate- And Gum Arabic-Based Liposomal Carboplatin Delivery System, Israa R. Mohammed, Fatimah J. Al-Hasani, Emad S. Al-Hasani
Comparative Study Of Alginate- And Gum Arabic-Based Liposomal Carboplatin Delivery System, Israa R. Mohammed, Fatimah J. Al-Hasani, Emad S. Al-Hasani
Engineering and Technology Journal
Carboplatin is a common chemotherapeutic drug that has systemic toxicity and low selectivity. This study compares two liposomal drug delivery systems based on natural materials, alginate and gum Arabic, and evaluates the effect of the polymer structure on nanoparticle characteristics, drug release, and anticancer activity. The novelty of this work is the direct link between the polymer architecture and the performance of the drug delivery system on the same platform. Nanoscale formulations were successfully prepared for both formulations. The particle size of gum Arabic was significantly smaller (50 nm) than that of the alginate (170 nm). TEM confirmed the presence …
Flagellar Coordination In A Swimming Multicellular Bacterium, Erandi Sachinthanie Imiya Mudiyanselage, Melina Mati, Alexander P. Petroff
Flagellar Coordination In A Swimming Multicellular Bacterium, Erandi Sachinthanie Imiya Mudiyanselage, Melina Mati, Alexander P. Petroff
Physics
Microbial locomotion is well understood when cells use either a small number of flagella or a high density of cilia. However many microbes live in an intermediate regime where coordination strategies such as flagellar bundles and metachronal waves are not possible. The mechanisms by which such organisms coordinate the motion of their swimming appendages are not well understood. Here, we study the only known obligatory multicellular bacterium, which are of the genus Magnetoglobus. Cells of this genus live exclusively in spherical communities called consortia, which are composed of a monolayer of tens of cells. Approximately a thousand of flagella project …
Scaffolding Minimum Age Thresholds, Eve Rips
Wounded Domestic Ecologies: Ecofeminist Readings Of Gendered Trauma In Purple Hibiscus, Erere Victory Iwhi
Wounded Domestic Ecologies: Ecofeminist Readings Of Gendered Trauma In Purple Hibiscus, Erere Victory Iwhi
Theses and Dissertations
This thesis examines Chimamanda Ngozi Adichie's Purple Hibiscus through an ecofeminist and postcolonial ecocritical lens, developing the concept of "wounded domestic ecology" to analyze how gendered violence operates within domestic space. Drawing on trauma studies, particularly J. R. Kurtz and Rob Nixon's concept of slow violence, it argues that harm in the novel is accumulative, produced through repetition, surveillance, ritual, and spatial regulation. Eugene's household functions as an environment that disciplines bodies, governs language, and embeds fear into everyday life. In contrast, Aunt Ifeoma's home in Nsukka offers a counter-ecology structured by sound, shared labor, and dialogic authority, interrupting the …
The Shrinking Caspian Sea: Eco‐Hydrological Responses To Human And Climate Pressures, Jesse Duku, Mohammad J. Tourian, Marzi Azarderakhsh, Rovshan Abbasov, Ali Mehran, Ali Torabi Haghighi, Stefanos Xenarios, Azara Boschee, Salih Babagiray, Mojtaba Sadegh, Nima Shokri, Ali Nazemi, Alireza Farahmand, Samaneh Ashraf, Temur Khujanazarov, Elmira Hassanzadeh, Dalal Najib, Daniel Placht, Shamshagul Mashtayeva, Ekaterina Rets, Hamid Norouzi, Kaveh Madani, Manoochehr Shirzaei, Hossein Shafizadeh-Moghadam, Chiyuan Miao, Ali Mirchi, Shuo Wang, Amir Aghakouchak
The Shrinking Caspian Sea: Eco‐Hydrological Responses To Human And Climate Pressures, Jesse Duku, Mohammad J. Tourian, Marzi Azarderakhsh, Rovshan Abbasov, Ali Mehran, Ali Torabi Haghighi, Stefanos Xenarios, Azara Boschee, Salih Babagiray, Mojtaba Sadegh, Nima Shokri, Ali Nazemi, Alireza Farahmand, Samaneh Ashraf, Temur Khujanazarov, Elmira Hassanzadeh, Dalal Najib, Daniel Placht, Shamshagul Mashtayeva, Ekaterina Rets, Hamid Norouzi, Kaveh Madani, Manoochehr Shirzaei, Hossein Shafizadeh-Moghadam, Chiyuan Miao, Ali Mirchi, Shuo Wang, Amir Aghakouchak
Publications and Research
The Caspian Sea, the Earth's largest inland water body, faces water level decline, drawing comparisons to the collapse of the Aral Sea. Unlike the Aral Sea, the relative roles of climatic variability, hydrological changes, and anthropogenic pressures on the Caspian Sea remain poorly understood. Here, we integrate satellite observations, in situ hydrological records and reanalysis data to examine recent drivers of the Caspian water loss. We show that total river inflow to the Caspian Sea has declined significantly, primarily due to reduced discharge from the Volga River. At the same time, precipitation over the basin has remained broadly stable, while …
Iris - Integrated Reef Information System, Colin Friedel, Zach Henderson, Cooper Mccarthy, Elias Pedroza, Thatcher Steele-Maley
Iris - Integrated Reef Information System, Colin Friedel, Zach Henderson, Cooper Mccarthy, Elias Pedroza, Thatcher Steele-Maley
Interdisciplinary Design Senior Theses
Our project provides an independent addition to the existing REEF Sensor Network, which has been created by the Santa Clara University Robotics Systems Lab and is planned to be deployed in the Palos Verdes Reef. Our system enables wireless transmission of data from the submerged sensor network to the scientist on land by designing and implementing a submersible winch mechanism to automatically raise and lower a buoy from the ocean floor to the surface, and cellular connectivity to wirelessly transmit collected data from the buoy to shore. After the data is transmitted, the buoy is lowered back to the sea …
Synthesis And Characterization Of Organometallic Polymers And Their Cytotoxicity Towards Human Cancer Cell Lines, Paul Peter Slawek
Synthesis And Characterization Of Organometallic Polymers And Their Cytotoxicity Towards Human Cancer Cell Lines, Paul Peter Slawek
Electronic Theses and Dissertations
This research aimed to synthesize organometallic polymers from dialkyl (methyl, ethyl, butyl, cyclohexyl, and octyl) and diaryl (phenyl) tin dichlorides and three organic monomers, dipicolinic acid (DPA), chloramphenicol (CH), and isomannide (IS), using interfacial polymerization. Structure-activity relationships were investigated through physicochemical characterization (light-scattering photometry, proton NMR, and IR spectroscopy) and cytotoxicity was evaluated against six human cancer cell lines (AsPC-1, PANC-1, MCF-7, MDA-MB-231, HT-29, PC-3), with cisplatin serving as the reference standard.
Five DPA/tin polymers were synthesized, with IC50 values in the range of 0.60–0.71 μg/mL. Their cytotoxicity was significantly lower than that of cisplatin (0.0023-0.044 μg/mL), suggesting that …
Decoding Growth Hormone Actions On Human Growth Plate Stem Cells, Shion Orikasa, Noriaki Ono
Decoding Growth Hormone Actions On Human Growth Plate Stem Cells, Shion Orikasa, Noriaki Ono
Faculty, Staff and Student Publications
The epiphyseal growth plate is the key target of growth hormone (GH) therapy. Although growth plate stem cells are well defined in mice, their presence in humans was unclear. Using rare surgical specimens, the study by Chu et al. reveals conserved, GH-responsive stem cells in the human pubertal growth plate.
Analysis Of The Relationship Between The Timing Of Foot Pressure Mechanics And Force At The Moment Of Leaping And The Accuracy Of Heading Of Young Football Players, Widad Kadhim Majeed, Huda Shihab Jari, Mariam Abduljabbar Khudhair, Félix Arbinaga Ibarzábal
Analysis Of The Relationship Between The Timing Of Foot Pressure Mechanics And Force At The Moment Of Leaping And The Accuracy Of Heading Of Young Football Players, Widad Kadhim Majeed, Huda Shihab Jari, Mariam Abduljabbar Khudhair, Félix Arbinaga Ibarzábal
Modern Sport
Football is a dynamic sport that requires both physical and technical skill because it is played within a specific timeframe and in a large space; physical ability is inseparable from technical proficiency among a match. This research aims to analyze the relationship between the timing of foot pressure, force generated at take-off, and heading accuracy in youth football players. A descriptive correlational approach was used on a sample of (8) players. Data were collected using a Foot Scan platform andvideo analysis. The results it was significant correlations between biomechanical variables and heading accuracy. The highest recorded correlation reached (R = …
The Shrinking Caspian Sea: Eco-Hydrological Responses To Human And Climate Pressures, Jesse Duku, Mohammad J. Tourian, Marzi Azarderakhsh, Rovshan Abbasov, Ali Mehran, Ali Torabi Haghighi, Stefanos Xenarios, Azara Boschee, Salih Babagiray, Mojtaba Sadegh, Nima Shokri, Ali Nazemi, Alireza Farahmand, Samaneh Ashraf, Temur Khujanazarov, Elmira Hassanzadeh, Dalal Najib, Daniel Placht, Shamshagul Mashtayeva, For Full Author List, See Comments Below
The Shrinking Caspian Sea: Eco-Hydrological Responses To Human And Climate Pressures, Jesse Duku, Mohammad J. Tourian, Marzi Azarderakhsh, Rovshan Abbasov, Ali Mehran, Ali Torabi Haghighi, Stefanos Xenarios, Azara Boschee, Salih Babagiray, Mojtaba Sadegh, Nima Shokri, Ali Nazemi, Alireza Farahmand, Samaneh Ashraf, Temur Khujanazarov, Elmira Hassanzadeh, Dalal Najib, Daniel Placht, Shamshagul Mashtayeva, For Full Author List, See Comments Below
Faculty Research, Scholarly, and Creative Activity
The Caspian Sea, the Earth's largest inland water body, faces water level decline, drawing comparisons to the collapse of the Aral Sea. Unlike the Aral Sea, the relative roles of climatic variability, hydrological changes, and anthropogenic pressures on the Caspian Sea remain poorly understood. Here, we integrate satellite observations, in situ hydrological records and reanalysis data to examine recent drivers of the Caspian water loss. We show that total river inflow to the Caspian Sea has declined significantly, primarily due to reduced discharge from the Volga River. At the same time, precipitation over the basin has remained broadly stable, while …
Common Octopus (Octopus Vulgaris) Blooms Off The Southwest Of The Uk: History, Trends, Causes And Consequences.: Report On Work Package 2: Fisheries Independent Estimates Of Octopus Abundance And Behaviour., Bryce Stewart, Alice Hall, Tully Osmond, Keith Hiscock, Simon Thomas, Emma Sheehan
Common Octopus (Octopus Vulgaris) Blooms Off The Southwest Of The Uk: History, Trends, Causes And Consequences.: Report On Work Package 2: Fisheries Independent Estimates Of Octopus Abundance And Behaviour., Bryce Stewart, Alice Hall, Tully Osmond, Keith Hiscock, Simon Thomas, Emma Sheehan
School of Biological and Marine Sciences
Since early 2025, a nearly unprecedented bloom of common octopus (Octopus vulgaris) has occurred off the southwest UK coast. Although native to UK waters, the species is usually rare, making this the largest bloom recorded in at least 75 years. While many octopus have been commercially landed, they have also preyed heavily on economically important shellfish species, including brown crab, European lobster and king scallop. Landings of these species declined sharply in 2025, causing significant hardship for many in inshore fishing communities. In response, a rapid research project was commissioned in August 2025 to investigate the history, causes and impacts …
Monoclonal Antibodies Targeting Pcdh7 Inhibit Tumor Growth And Enhance Immune Responses In Kras-Mutant Non-Small Cell Lung Cancer, Nicole Novaresi, Poorva Ghosh, Shayna Thomas-Jardin, Hui Deng, Xuejun Fan, Zhiqiang Ku, Wei Xiong, Xiaorong Zhou, Jingfei Zhu, Huiyu Li, Mahesh S Padanad, Bethany Smith, Chul Ahn, John D Minna, Zhiqiang An, Ningyan Zhang, Kathryn A O'Donnell
Monoclonal Antibodies Targeting Pcdh7 Inhibit Tumor Growth And Enhance Immune Responses In Kras-Mutant Non-Small Cell Lung Cancer, Nicole Novaresi, Poorva Ghosh, Shayna Thomas-Jardin, Hui Deng, Xuejun Fan, Zhiqiang Ku, Wei Xiong, Xiaorong Zhou, Jingfei Zhu, Huiyu Li, Mahesh S Padanad, Bethany Smith, Chul Ahn, John D Minna, Zhiqiang An, Ningyan Zhang, Kathryn A O'Donnell
The Brown Foundation: Institute of Molecular Medicine
We identified an important oncogenic role for protocadherin 7 (PCDH7), a cell surface protein frequently overexpressed in lung adenocarcinoma and associated with poor clinical outcome. Pcdh7 depletion reduces tumor burden and prolongs survival in KrasLSL-G12D; Tp53fl/fl mice. These findings nominate this cell surface protein as an actionable therapeutic target and highlight the therapeutic potential of PCDH7 inhibition for non–small cell lung cancer. We report the development and characterization of high-affinity anti-PCDH7 monoclonal antibodies (mAbs) that inhibit downstream mitogen-activated protein kinase (MAPK) pathway activation and suppress tumor growth in multiple mutant KRAS–driven models. A lead mAb (mAb7) sensitized tumors …
Amc-F1 Regulates Mitochondria-Autophagy Crosstalk Independent Of Nutrient Stress, Yuqin Wang, Raksha K Rao, Trung Vu, Ayano Sekine, Zhengmei Mao, Nami Mccarty
Amc-F1 Regulates Mitochondria-Autophagy Crosstalk Independent Of Nutrient Stress, Yuqin Wang, Raksha K Rao, Trung Vu, Ayano Sekine, Zhengmei Mao, Nami Mccarty
The Brown Foundation: Institute of Molecular Medicine
Mitochondria and autophagy are fundamental yet distinct regulators of cellular homeostasis. Here, we identify AMC-F1 (Autophagy-Mitochondria Coupling Factor 1; formerly TRIM44) as a central integrator of mitochondrial bioenergetics and autophagy. Using Amcf1 knockout and knock-in mouse models, we demonstrate that AMC-F1 bidirectionally regulates these pathways: its loss reduces mitochondrial respiration and autophagic flux, whereas its overexpression promotes mitochondrial elongation and increases autophagy independently of nutrient stress. Transcriptomic analyses reveal AMC-F1-dependent regulation of mitochondrial biogenesis programs that engage autophagy, involving mitochondrial respiratory chain complex genes under basal conditions and mitochondrial organization factors under starvation-induced autophagy. Although dispensable under homeostasis, this coupling …
Statistical Methods In Research, Horahenage Dixon Vimalajeewa
Statistical Methods In Research, Horahenage Dixon Vimalajeewa
UNL Faculty Course Portfolios
This course portfolio documents the design, delivery, assessment, student-learning evidence, and reflective evaluation of STAT 801A-700: Statistical Methods in Research, an online asynchronous service course designed to introduce students from diverse disciplinary backgrounds to foundational statistical reasoning and applied data analysis. The course is a non-calculus-based introduction to statistical methods used to answer research questions, with emphasis on collecting, organizing, describing, analyzing, and drawing conclusions from data. The course also emphasizes applications relevant to biology, agriculture, and other research-oriented fields. This is an online distance course aimed to develop students’ understanding of basic probability and statistical concepts, recognize the importance …
Chromatin Insulators Homie And Nhomie Can Interact With Distant Copies Either Together Or Separately, With Distinct Outcomes For Enhancer-Promoter Interactions, Miki Fujioka, Wenfan Ke, Paul Schedl, James B. Jaynes
Chromatin Insulators Homie And Nhomie Can Interact With Distant Copies Either Together Or Separately, With Distinct Outcomes For Enhancer-Promoter Interactions, Miki Fujioka, Wenfan Ke, Paul Schedl, James B. Jaynes
Department of Biochemistry and Molecular Biology Faculty Papers
Chromatin insulators, a.k.a. boundary elements, separate regions of the chromosome with distinct chromatin characteristics, including distinct histone modifications. This activity affects gene expression by allowing chromatin domains to be stably regulated and maintained. Insulators also block enhancer-promoter interactions and, somewhat paradoxically, facilitate other interactions, particularly when they stitch together distant regions of the chromosome by pairing with specific partners. Here we explore how long-range interactions facilitated by insulator pairing are affected by the presence of two potentially competing partners. Our results show that when two partners are present, they can reduce each other's effects on distant gene expression, suggesting that …
Uncovering Dkk1 As A Therapeutically Relevant Target In Aggressive Er+ Breast Cancer Using A Novel Antiestrogen, Kristen Young
Uncovering Dkk1 As A Therapeutically Relevant Target In Aggressive Er+ Breast Cancer Using A Novel Antiestrogen, Kristen Young
Dissertations
Over 70 percent of breast cancers are estrogen receptor-positive (ERα+), meaning that the hormone estrogen drives tumor growth. Although first-line targeted therapies that directly block ERα from hormone-dependent pathologies are initially effective, almost half of patients ultimately progress. These patients show high mutational rates to the ESR1 gene that encodes for ERα. A hotspot missense tyrosine to serine mutation at position 537 (Y537S) initiates hormone-independent, allele-specific transcriptional programs that increase metastasis. While next-generation ERα-targeted therapies show promise, benefits are often limited compared to standard-of-care. Understanding the mechanisms of action used by the Y537S ESR1 breast cancer cells to evade therapeutic …
Discovery Of Bmi-Associated Gut Microbiome Signatures In The Awi-Gen 2 Cohort, Meriem Yagoubi
Discovery Of Bmi-Associated Gut Microbiome Signatures In The Awi-Gen 2 Cohort, Meriem Yagoubi
Theses and Dissertations
Obesity is increasing across sub-Saharan Africa amid rapid dietary, environmental, and urbanization transitions, yet the gut microbiome features associated with adiposity in African populations remain under-characterized. This study investigated whether species-level gut microbiome composition is associated with body mass index (BMI) in the AWI-Gen 2 cohort, and whether BMI-associated microbial signals remain detectable after accounting for the dominant geographic structure of the microbiome. Gut microbiome community structure and diversity were characterized across 1,665 participants, and differential abundance analysis was used to identify taxa associated with BMI after controlling for study site. Machine learning models were then trained to assess how …
Ambivalence, Foremourning, And Displacement In The German Translation Of Marie Bonaparte's Topsy, Kooper Wilson
Ambivalence, Foremourning, And Displacement In The German Translation Of Marie Bonaparte's Topsy, Kooper Wilson
University Honors Theses
This paper offers a reading of Sigmund Freud’s German translation of Marie Bonaparte’s book, Topsy: The Golden-Haired Chow, in which the author attempts to both delay the death of her dog and mourn it in advance through what I call foremourning. I argue that the manifest subject matter of Topsy should not be interpreted away as a projection of merely human concerns, but rather that close attention to Freud’s translation introduces themes from his analytic experience which engender an appreciation of Topsy’s atopia (intractability). I draw from recent psychoanalytic theory, literary criticism, and deconstruction, especially Jacques Derrida’s seminars …
Synthesis And Characterization Of Synergistic Bioactive– Organometallic Condensation Polymers, Francesca Isabel Mosca
Synthesis And Characterization Of Synergistic Bioactive– Organometallic Condensation Polymers, Francesca Isabel Mosca
Electronic Theses and Dissertations
This research focuses on the synthesis and structural characterization of polymers with anticipated anticancer and antiviral properties by combining metal-containing Lewis acids, organotin dichlorides (R2SnCl2), Group 4 metallocene dichlorides (Cp2TiCl2, Cp2ZrCl2 and Cp2HfCl2), and triphenyl Group 15 metal dichlorides (Ph3AsCl2, Ph3SbCl2 and Ph3BiCl2), with biologically active Lewis bases, lamivudine, a synthetic nucleoside, and camphoric acid, a dicarboxylic acid, to achieve synergistic effect.
Five classes of polymers were synthesized using interfacial polymerization: lamivudine and organotin dichlorides, lamivudine and Group 4 metallocene dichlorides, camphoric acid and triphenyl Group 15 metal dichlorides, camphoric acid and organotin dichlorides, and camphoric acid and Group 4 …
Safety And Synergy Of Finerenone And Empagliflozin In Lowering Blood Pressure, Rajiv Agarwal, Ricardo Correa-Rotter, Sankar D Navaneethan, Hiddo J L Heerspink, Matthew R Weir, Janet B Mcgill, Amy K Mottl, Masaomi Nangaku, Julio Rosenstock, Peter Rossing, Muthiah Vaduganathan, Charlie Scott, Li Li, Meike Brinker, Csaba P Kovesdy, Jennifer B Green, Johannes F E Mann
Safety And Synergy Of Finerenone And Empagliflozin In Lowering Blood Pressure, Rajiv Agarwal, Ricardo Correa-Rotter, Sankar D Navaneethan, Hiddo J L Heerspink, Matthew R Weir, Janet B Mcgill, Amy K Mottl, Masaomi Nangaku, Julio Rosenstock, Peter Rossing, Muthiah Vaduganathan, Charlie Scott, Li Li, Meike Brinker, Csaba P Kovesdy, Jennifer B Green, Johannes F E Mann
Faculty, Staff and Students Publications
Background: This secondary analysis of the CONFIDENCE (combination effect of fInerenone and empagliflozin in participants with chronic kidney disease and type 2 diabetes using a UACR endpoint) trial (REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05254002) assessed systolic blood pressure (SBP) changes with empagliflozin/finerenone combination therapy versus monotherapy in people with chronic kidney disease and type 2 diabetes across baseline SBP categories. We assessed SBP response predictors and whether early (day 30) SBP changes mediate urinary albumin-to-creatinine ratio reductions.
Methods: Participants (n=800) were stratified by baseline SBP (< 130 mm Hg; ≥130 mm Hg). Outcomes included SBP response (≥10 mm Hg reduction from baseline at day 180) and longitudinal SBP changes, analyzed by linear mixed-effects models and logistic regression. Causal mediation analysis, a secondary exploratory analysis, evaluated the effect of day 30 SBP change on day 180 urinary albumin-to-creatinine ratio reduction.
Results: At baseline, 532 (66%) participants had SBP ≥130 mm Hg; 268 (34%) …
Growth In Early Infancy Drives Optimal Brain Functional Connectivity Which Predicts Cognitive Flexibility In Later Childhood, Chiara Bulgarelli, Anna Blasi, Samantha Mccann, Bosiljka Milosavljevic, Giulia Ghillia, Ebrima Mbye, Ebou Touray, Tijan Fadera, Lena Acolatse, Sophie E Moore, Sarah Lloyd-Fox, Clare E Elwell, Adam T Eggebrecht, Bright Study Team
Growth In Early Infancy Drives Optimal Brain Functional Connectivity Which Predicts Cognitive Flexibility In Later Childhood, Chiara Bulgarelli, Anna Blasi, Samantha Mccann, Bosiljka Milosavljevic, Giulia Ghillia, Ebrima Mbye, Ebou Touray, Tijan Fadera, Lena Acolatse, Sophie E Moore, Sarah Lloyd-Fox, Clare E Elwell, Adam T Eggebrecht, Bright Study Team
2020-Current year OA Pubs
Functional brain network organisation, measured by functional connectivity (FC), reflects key neurodevelopmental processes for healthy development. Early exposure to adversity, for example undernutrition, affects neurodevelopment, observable via disrupted FC, and leads to poorer outcomes from preschool age onwards. We assessed longitudinally the impact of early growth trajectories on developmental FC in a rural Gambian population from age 5-24 months. To investigate how these early trajectories relate to later childhood outcomes, we assessed cognitive flexibility at 3-5 years. We observed that early physical growth before the fifth month of life drove optimal developmental trajectories of FC that in turn predicted cognitive …
Relationship Between Sleep And Meal Timing With Glycemia Parameters In Individuals With Obesity Participating In A Randomized Time-Restricted Eating Study., Sirimon Reutrakul, Stacey L. Simon, Qi Wang, Emily N C Manoogian, Satchindananda Panda, Suryeon Ryu, Zan Gao, Caleb Griffiths, Erika Helgeson, Douglas G. Mashek, Niki Oldenburg, Lisa Senye Chow
Relationship Between Sleep And Meal Timing With Glycemia Parameters In Individuals With Obesity Participating In A Randomized Time-Restricted Eating Study., Sirimon Reutrakul, Stacey L. Simon, Qi Wang, Emily N C Manoogian, Satchindananda Panda, Suryeon Ryu, Zan Gao, Caleb Griffiths, Erika Helgeson, Douglas G. Mashek, Niki Oldenburg, Lisa Senye Chow
Manuscripts, Articles, Book Chapters and Other Papers
Background/Objectives: Circadian misalignment, including mistimed sleep or eating, is associated with altered glucose metabolism. The importance of eating window timing for time-restricted eating (TRE) is increasingly recognized. This secondary analysis examined associations between meal to sleep timing intervals and glycemic parameters in individuals with obesity across three dietary interventions [TRE, CR: caloric restriction, and UE: unrestricted eating]. Methods: Participants aged 18-65 years with obesity were randomized to a 12-week intervention: TRE (8 h eating window), CR (15% reduction in daily caloric intake), or UE (usual eating habits). CGM and actigraphy were assessed over two weeks at baseline and end-intervention. Mixed …
Imaging And Non-Imaging Approaches For The Diagnosis And Monitoring Of Necrotizing Enterocolitis-What Lies Ahead?, Indrani Bhattacharjee, Catalina Le Cacheux, Eric B. Ortigoza, Jonathan Dillman, Sherwin S. Chan, Alain Cuna
Imaging And Non-Imaging Approaches For The Diagnosis And Monitoring Of Necrotizing Enterocolitis-What Lies Ahead?, Indrani Bhattacharjee, Catalina Le Cacheux, Eric B. Ortigoza, Jonathan Dillman, Sherwin S. Chan, Alain Cuna
Manuscripts, Articles, Book Chapters and Other Papers
Necrotizing enterocolitis (NEC) remains one of the most serious gastrointestinal emergencies in preterm infants, and imaging plays a central role in diagnosis and clinical management. Historically, evaluation has relied primarily on abdominal radiography, which remains widely available and embedded in established diagnostic frameworks. However, the hallmark radiographic signs of NEC (i.e., pneumatosis intestinalis, portal venous gas, and free air) reflect relatively advanced manifestations of intestinal injury that indicate established mucosal disruption or transmural necrosis. Bowel ultrasound has increasingly complemented radiography by enabling real-time assessment of bowel wall integrity, perfusion, motility, and intra-abdominal fluid, providing physiologic information that may refine clinical …
Stress-Activated Pathways Mediate Pfas Effects On Human Placental Syncytiotrophoblast Cells., Keisuke Kozai, Kaela Varberg
Stress-Activated Pathways Mediate Pfas Effects On Human Placental Syncytiotrophoblast Cells., Keisuke Kozai, Kaela Varberg
Manuscripts, Articles, Book Chapters and Other Papers
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants associated with placenta-mediated pregnancy complications, including preeclampsia, fetal growth restriction, and preterm birth. The syncytiotrophoblast (STB), which forms the placental barrier at the maternal-fetal interface and is directly exposed to maternal blood, is a primary site of PFAS exposure. Although PFAS induce STB apoptosis, the upstream stress-signaling pathways involved remain poorly defined. Here, we investigated stress-responsive signaling mechanisms mediating PFAS-induced STB cell death. STB differentiated from human trophoblast stem cells were exposed to vehicle or an environmentally relevant mixture of 5 PFAS (perfluorooctanoic acid, perfluorooctanesulfonic acid, perfluorohexane sulfonate, perfluorononanoic acid, and …
Evaluating Chest-Worn Light Logger Adherence: Development And Application Of A Wear/Non-Wear Model, Carlyn Patterson Gentile, Adah Thomas, Ryan Shah, Blanca Marquez De Prado, Nichelle Raj, Christina Szperka, Geoffrey Aguirre
Evaluating Chest-Worn Light Logger Adherence: Development And Application Of A Wear/Non-Wear Model, Carlyn Patterson Gentile, Adah Thomas, Ryan Shah, Blanca Marquez De Prado, Nichelle Raj, Christina Szperka, Geoffrey Aguirre
Student Papers, Posters & Projects
Light exposure plays an important role in overall health because it entrains circadian rhythms. Recent technological advances in wearable light loggers allow measurement daily light exposure habits. Using a chest-worn light logger, our goal was to (1) develop methodology for differentiating adherent versus non-adherent use, and (2) define differences in lighting intensity in indoor and outdoor environments, to improve data reliability in future clinical studies using this technology. Four testers used a 10-channel chest worn light logging device under different conditions of wear and non-wear (experiment 1), and another tester made measurements with the light logger across a variety of …
Integration Of Research Software In Open Scholarship, Michelle Barker, Daniel S. Katz
Integration Of Research Software In Open Scholarship, Michelle Barker, Daniel S. Katz
FORCE 2026
The Research Software Alliance’s Publishing Research Software Forum is a collaboration of publishers committed to recognizing research software as fundamental and vital to research, supporting it, and connecting it and its developers to research publications. The forum provides a formal mechanism for members to share practices and consider how to individually and collectively address common challenges to achieve the significant cultural change needed across the research sector globally.
This presentation will share the forum’s work to increase policy alignment and implementation; incentives and enforcements to support researcher citation of research software; and alignment with broader efforts to improve citation of …
Political Power In The Digital Shadows: The Surveillance State And Far-Right Party Strength In Central And Eastern Europe, Abby K. Finley
Political Power In The Digital Shadows: The Surveillance State And Far-Right Party Strength In Central And Eastern Europe, Abby K. Finley
Political Science Honors Projects
The recent rise of far-right leaders, from Donald Trump challenging democratic institutions in the United States to Viktor Orbán's fifteen-year autocratic reign in Hungary, has led me to my main research question: Why are some far-right parties stronger than others? Conducting process tracing analysis of Hungarian, Polish, Slovak, and Czech far-right politics from 2005 to 2025, I argue that far-right parties are stronger when they utilize the surveillance state to limit democratic institutions and actors. My findings clarify how far-right parties use the surveillance state and other tactics to maintain power within their nation.