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In Vivo Orf Overexpression Screening Identifies Ccn4 As A Regulator Of Glioblastoma Growth Validated Across Multiple Models, Pushan Dasgupta

Faculty, Staff and Students Publications

Despite current multimodal therapies for glioblastoma (GBM), its prognosis remains grim. Thus, a tremendous need exists to identify new genetic drivers that may serve as potential therapeutic targets in glioblastoma (GBM). We describe an in vivo overexpression screening strategy to identify drivers of glioblastoma where we have leveraged TCGA datasets to conduct a functional genomics screen of prioritized open reading frames (ORFs) that are overexpressed and/or amplified in GBM. To interrogate these potential drivers within a more relevant physiological context, the screening was accomplished in vivo in an orthotopic patient-derived glioma stem-like cell (GSC) model. Among 5 positive "hits" from …

Pregnancy In Type I Interferon Receptor (Ifnar2) Knockout Sheep Challenges The Accepted Paradigm For Pregnancy Recognition In Ruminants, Christopher J. Davies, Evan K. Peterson, Aaron J. Thomas, Andrea L. Giles, Young-Min Lee, Irina A. Polejaeva, Heloisa M. Rutigliano

Veterinary Clinical and Life Science Faculty Publications

The effects of type I interferons, including interferon tau (IFNT), previously thought to be the signal for pregnancy recognition in ruminants, are mediated by the type I interferon receptor (IFNAR), a heterodimer comprised of IFNAR1 and IFNAR2. The genes encoding IFNAR were disrupted in fetal fibroblast cells using CRISPR/Cas9 and lambs were produced by somatic cell nuclear transfer (SCNT). Subsequently, a herd of IFNAR2^+/− sheep was developed and used to produce IFNAR2^−/− lambs. Functional knockout of IFNAR was confirmed by failure of fibroblast cell lines from IFNAR2^−/− sheep to respond to interferon alpha or IFNT in a …

Diagnosis Of Covid-19 Impact On The Construction Employment: Decline And Recovery, Anil Baral, Abdullah Alnuaimi, Yunping Liang, Baabak Ashuri, Mohsen S. Shahandashti

Durham School of Architectural Engineering and Construction: Faculty Publications

The Coronavirus Disease 2019 (COVID-19) had an unprecedented impact on U.S. construction employment. The assessment of employment declines and recoveries across various construction sectors, workforce demographics, and geographic regions helps develop inclusive long-term plans to overcome the setbacks of natural hazards, such as the COVID-19 pandemic. Existing methods for quantifying the employment decline from sudden shocks do not consider trends and seasonality of construction employment under normal conditions. Hence, it is not clear whether the employment declines are due to the impact of a disaster or associated with trends and seasonal patterns of employment. The objective of this research is …

Psychogastroenterology: An Introduction For Behavioral Health And Healthcare Professionals, Jerrod Brown Ph.D., M.A., M.S., M.S., M.S., M.S., M.S., Jeremiah B. Schimp Phd, Ma, Lpcc, Leanne Skehan Dcn, Msacn, Mph, Mba, Cns, Ches, Shelley Mydra Dmft, Lmft, Jonathan Ward Dc, Phd(C), Ms, Dibcn, Tiffany Flaten Cns, Ldn

Nutritional Neurocriminology Today

Although often difficult to discuss with clients, gastrointestinal (GI) issues affect an estimated 60 to 70 million Americans (American Gastroenterological Association, 2022). Yet only about 25% of those experiencing these conditions receive treatment. This is troubling because GI issues frequently co-occur with clinically significant consequences for physical health, psychological well-being, daily functioning, and overall quality of life. Designed for behavioral health and healthcare professionals, this brief article introduces the field of psychogastroenterology, with emphasis on symptoms, stigma, diagnosis, and treatment. Key topics include the gut-brain axis, common digestive health conditions, and the mental health implications associated with gastrointestinal disorders.

Pretty Much From Scratch: A Braided Essay On Autistic Diagnosis, Creativity, Identity, And Community, Jenée Stanfield

Ought: The Journal of Autistic Culture

This braided essay uses memoir and research to explore autistic diagnosis, creativity, identity, and community. It examines how the misinformation around these topics harm and “other” autistics: the fallacy of diagnostic objectivity/neutrality, the dual myths of autistic hyper- and hypo-creativity, and autism as an identity defined solely by medical professionals. The memoir sections play with point of view and genre.

Jenée is a late-realized autistic with ADHD and OCD, who identifies as neurodivergent and neuroqueer. She lives in Washington state with her spouse and dog. She has a Master of Fine Arts in Creative Writing and is currently a Master …

Opening Portals To The Posthuman: A Pedagogical Framework For Materializing Philosophy, Carlos Henrique Araujo De Aguiar

DRS Biennial Conference Series

This paper critiques dominant design pedagogies for their alignment with positivist and modernist paradigms, which limit design’s capacity for serious philosophical inquiry. It argues that Speculative and Critical Design (SCD) pedagogy offers an alternative philosophy, functioning as a powerful method for fomenting critical engagement by enabling students to materialize abstract concepts. Drawing on a case study from an undergraduate course on human-robot-cyborg relations, the paper employs the metaphor of 'portals' to analyse three thematic case studies. Each portal opens onto a distinct philosophical debate: the nature of reality and the self, the biopolitics of the body, and the networked subject. …

User-Centered Dread: A Lovecraftian Critique Of Design, Lewis Urquhart, Emma Lawrie

DRS Biennial Conference Series

This paper offers a speculative critique of contemporary design practice through the lens of Lovecraftian horror by critically interrogating assumptions embedded in user-centered design theory. Drawing on the oeuvre of 'weird fiction' author H.P. Lovecraft’s cosmically pessimistic mythologies, this paper explores three thematic dimensions - control, user unknowability, alien materiality - to reveal the limitations of human-centred design paradigms. Utlising examples from literature, film, and everyday experience, this critique demonstrates how design’s aspirational narratives, centered on mastery, empathy, and progress, are increasingly inadequate in addressing the complexities of a more-than-human world. The concept of 'user-centered dread' emerges as a central …

Emerging Hybrid Human-Genai Workflows To Optimise Human Ideation, Sketching And Design, Mauricio Novoa Munoz, Juan Antonio Islas Munoz, Alejandro Lozano Robledo

DRS Biennial Conference Series

This article presents findings on the reciprocal relationship between industrial design education and the industry it prepares graduates for. Particularly considering the growing impact of Generative Artificial Intelligence (GenAI) on ideation, sketching, design methodologies, and productivity. To inform this research, industry professionals currently integrating GenAI into their practice were consulted to establish benchmarks and highlight critical areas for updated pedagogical approaches and digital transformation, thereby ensuring that design learning and productivity workflows remain relevant. The study arises from an awareness of current workforce shifts that are anticipated to become more pronounced soon. Rapid technological advancements are driving significant cultural and …

Interspecies: A Collaborative Curatorial Inquiry Into New Romanticism, Mariana Pestana, Katerina Inglezaki, Carlos Pastor, Mathilde Gouin, Bernardo Gaeiras, Fernanda Costa, Mariana Simões

DRS Biennial Conference Series

This paper presents a situated, plural, and horizontal curatorial methodology centered on questioning rather than providing solutions in response to posthuman thought and practice. It inquires whether we might be witnessing the emergence of a New Romanticism in contemporary design and architecture concerned with interspecies relations. This romantic turn arises by acknowledging subjectivity and imagination while engaging critically with the complexities of the climate crisis. To this end, this paper examines the making of an exhibition that assembled material evidence from science, art, technology, and design. The exhibition was developed through a three-step curatorial framework aligned with the decentering narratives …

Making Sense Of Pain: Participatory Design Approaches To Understanding And Supporting People Living With Chronic Pain, Ivana Nakarada-Kordic, Jannisa Seck, Nathan Beetge, Cassandra Khoo, Stephen Reay

DRS Biennial Conference Series

Pain is universal, yet its invisible nature makes it difficult to express or understand. Understanding the intricate mechanics of chronic pain and how to manage it effectively can be particularly challenging. This paper describes research exploring how human-centred design, transdisciplinary collaboration, and participatory approaches can produce diverse design outcomes that support the management and treatment of chronic pain. Two case studies are presented: 1) an exploration of how pain might be expressed through illustration and storytelling to offer insight into lived experience, and 2) how experiences of pain could be made more tangible through physical artefacts to support patient–clinician communication. …

Designing For Radical Renewal: Innovation Outcomes Across Circular And Regenerative Approaches, Belinda Nors, Louise Møller Haase, Sara Nielsen

DRS Biennial Conference Series

This paper defines regenerative design in relation to current collaborative, sustainability-oriented innovation. Production and consumption patterns are largely linear, with circular economy efforts largely focused on recycling. Regenerative approaches are emerging but underdeveloped. Literature describes the Regenerative worldview and theoretical framework, and the few papers on methodology and practice highlight a need for greater definition of the field. An actionable design- and innovation methodology for the regenerative field is lacking. We conduct a scoping review and define the Regenerative design approach in relation to the current Circular Oriented Design approaches. We present the characteristics of the Value Preserving and Regenerative …

Designing Algorithmic Infrastructures For Environmental Regeneration: Autonomous Systems In Marine Contexts, Oğul Görgülü, Ahmet Can Özcan, Anders Berglund

DRS Biennial Conference Series

In an era shaped by autonomous systems, designers increasingly confront a central question: how should responsibility and decision-making be distributed when environmental action is partially delegated to algorithms? This article explores how AI infrastructures in marine environmental operations reshape relations between human intention, machine autonomy, and ecological care. Drawing on posthuman design theory, Actor–Network Theory, and explainable AI, the study proposes an Ethics of Autonomy framework that positions design as a mediator between human oversight and algorithmic agency. Using a case-informed analysis of three marine robotic systems—FloatyBoats (coral restoration), Seaswarm (oil spill mitigation), and the autonomous surface vessel Vatoz (marine …

Mechanical Jewellery As Epimethean Practice: Staying With The Trouble Of Human–Machine Entanglement, Zhiyang Ding, Guang Dai, Beverley Hood, Sarah Kettley

DRS Biennial Conference Series

This paper explores how mechanical jewellery can serve as an Epimethean design practice that rethinks human–machine relationships through care, hesitation, and affective engagement. Drawing from post-anthropocentric design discourse and new materialist theory, the research investigates how low-tech, playful, and speculative prototypes can undo conventional narratives of technological progress. Through a practice-based workshop conducted at Fringe Arts Bath 2025, the study examines how wearable artefacts exhibiting unpredictable motion provoke emotional response and relational awareness in participants. The findings suggest that mechanical jewellery can operate as a modest yet generative medium for staying with the trouble of human–machine entanglement, foregrounding absurd materiality, …

Measuring Service-Related Subjective Wellbeing In Paediatric Oncology, Valentina Marques Da Rosa, Priscila Goergen Brust-Renck, Flavio Sanson Fogliatto, Leandro Miletto Tonetto

DRS Biennial Conference Series

Children’s hospitalisation affects more than physical health; it shapes children’s subjective wellbeing (SWB). Yet design researchers rarely systematically capture SWB. This study introduces the Subjective Wellbeing Questionnaire for Hospitalised Children (SWBQ-HC), a tool that measures children’s perceptions of themselves, hospital services, and spaces. Developed by combining validated psychological scales with service- and space-specific items, the tool was piloted with 19 paediatric patients (aged 4–13) and 35 parents. Factor analysis revealed four dimensions: Positive and Negative Feelings about Self, and Feelings about Hospital Services and Spaces. The results highlight the interplay between relational and environmental factors in shaping SWB and reveal …

Learning To Design With Communities: Situated Public Design Education Through The Roots Project In The Gambia, Mireia Sierra, Juan José Ramos, Ramon Bragos

DRS Biennial Conference Series

This paper presents the ROOTS Project, developed by interdisciplinary student teams from Esade, UPC, and IED within Fusion Point's Challenge-Based Innovation framework, in collaboration with IdeaSquare at CERN. As part of a challenge proposed by IDAEA-CSIC (Spain) and the Sankandi Youth Development Association (SYDA, The Gambia), students co-designed low-cost environmental monitoring tools to support community-led mangrove restoration in the River Gambia region. A two-week field deployment in Sankandi embedded the project within a layered local governance structure (the Alkalo, the Village Development Committee, and its Environmental Committee) through which the technology was formally adopted and transferred. Drawing on student reflections …

Can Textiles Be Alive? Exploring Transitional Materialities Through Microbial Biosensors And Textile Fluidics, Avantika Velho, Saurabh Mhatre, Varenya Sethumadhavan, Hann Tu, Neel Joshi, Katia Zolotovsky

DRS Biennial Conference Series

This paper explores materials in transition through Living Textiles, a platform that integrates genetically engineered whole-cell biosensors into textiles for on-body physiological and environmental sensing. The project investigates how textiles can act as computational and ecological systems, integrating living cells that sense their environment and communicate through material change. By combining biological sensing with textile craft, Living Textiles reframes smart materials as regenerative and cohabited rather than extractive and disposable. The research contributes to the field of transitional materials design by: (1) presenting new interaction possibilities with microbial cells; (2) developing methods for designing microenvironments that sustain life and sensing; …

Revisiting Kansei Engineering Through Japanese Scholarship: Toward Field Kansei Engineering, Liang Dong, Hong Zhang, Chun-Hsien Chen

DRS Biennial Conference Series

Japan, as the birthplace of Kansei Engineering (KE), has played a pivotal role in shaping this field, building a solid research foundation and accumulating extensive scholarly experience. A substantial body of valuable Japanese-language studies has been published in academic conferences and journals in Japan. However, current English-language review articles in KE rarely include these Japanese works. To address this gap, this study provides a preliminary attempt to compile and analyse Japanese publications that propose new concepts, theories, models, and frameworks within KE. The review highlights distinctive perspectives developed by Japanese scholars, revealing contextual and situational sensitivity, collective and social understanding, …

Design Research Laboratories: A Historical Review, Lynn Harles

DRS Biennial Conference Series

In recent decades, Design Research Labs have proliferated across design educational institutions worldwide, emerging as dynamic spaces that challenge traditional pedagogical models. However, understanding this contemporary phenomenon requires contextualizing it within the historical origins of the laboratory metaphor in design—a concept repeatedly reimagined over nearly a century. Building upon Hasenhütl's (2018, 2023) identification of two historical generations from the early to mid-20th century, this research extends the genealogy to encompass contemporary developments, with particular attention to socio-ecological themes. The analysis reveals four distinct generations of Design Research Labs that do not follow strictly linear chronological progression but represent "expanding parameters" …

Touch Wood: Stuckness, Risk Assessment, And Embodied Knowledge In Practice, Hugo Glover

DRS Biennial Conference Series

This practice-based research explores stuckness in creative work not as a problem to eliminate, but as a threshold state where tacit knowledge becomes operative. Drawing on autoethnographic narrative, I examine how attending to stuckness reveals the autonomic nervous system's (ANS) role in embodied knowing. Through a close reading of wood carving practice, I document how physical engagement with materials offered a way to work with, rather than overcome, stuckness. When invited to exhibit this work, I experienced acute stress that led me to adapt a Risk Assessment form—typically used for physical hazards—to map emotional risks such as shame and humiliation. …

Code Ecologies: Reclaiming Design As Meaning-Making Within Human–Ecological Systems, Laura Santamaria

DRS Biennial Conference Series

This paper reclaims the role of design as a practice of meaning-making within human–ecological systems. While meaning has always been part of design discourse, successive turns – semiotic, experiential, relational – have addressed what meaning is without asking why living systems make meaning at all. Drawing on recent advances in neuroscience, biosemiotics and code biology, it argues that meaning-making is not a cognitive phenomenon unique to humans but a regulatory process intrinsic to living systems. Code Ecologies offers a philosophical framework that reinterprets the biosphere, technosphere and semiosphere as interdependent ecologies of codes, resonant with relational and Indigenous cosmologies. The …

Material Agents At Work In Alternative Food Networks, Cagri G. Varli, Stefano Maffei

DRS Biennial Conference Series

Despite growing interest in sustainable food systems, their material dimension as active design agents (artefacts and infrastructures) remains largely unrecognized. This study challenges the positioning of packaging and distribution tools as passive elements, repositioning them as entities that shape the ongoing negotiation of ethics, responsibility, and co-dependence within food systems. Drawing on interviews, thing ethnography, and relational mapping across two alternative food network case studies, the study examines the roles of these material agents. The findings show that material artefacts contribute to the organization of care, responsibility, and continuity across both pragmatic and symbolic dimensions of food networks. Differences in …

Design For Coastal Futures: Rethinking Space And Time With A More-Than-Human And Transcultural Lens., Serena Pollastri, Juan Montalvan Lume, Louise Mullagh, Suzana Ilic

DRS Biennial Conference Series

Amid the intensifying challenges of climate change, there is an emerging consensus within coastal academic and practitioner networks on the importance of integrating design led-approaches that enhance resilience and foster the long-term adaptation for coastal communities. However, coastal environments present peculiar contexts for design actions, as the movement of water consistently challenges the boundaries between water and land, along with the relational interactions between human and non-human communities—both in cyclical and unpredictable ways. Drawing from the authors’ experiences in tidal coastal and estuarine areas across diverse geographies, this article proposes ways to cultivate design’s response-ability (Haraway, 2016) to the more-than-human …

A Messy Substance: Mediating The Stigma And Lived Experience Of Endometriosis Through Participatory Design, Carolina Vaz-Pires, Ricardo Melo

DRS Biennial Conference Series

Endometriosis is a chronic condition often surrounded by taboo, silence, and misunderstanding. Although diagnostic uncertainty and epistemic tensions shape endometriosis care, little is known about how design can address the communicative and relational gaps between patients and gynaecologists. This article investigates how participatory and speculative design can support communication between these groups. Using a Research through Design approach, three co-design workshops were conducted with six individuals with endometriosis and five doctors. Participants created analogue artefacts including empathy maps, body maps, clay representations, written narratives, speculative futures and collective posters that materialised embodied pain, emotional burden and clinical perspectives. The workshops …

Exploring Embodiment’S Impact On Autonomy And Agency In Behavioral Design, Ruth Schmidt

DRS Biennial Conference Series

The field of behavioral design uses insight into humans’ cognitive tendencies to help people make better, more rational choices. Yet individuals’ perceptions of what seems rational—let alone viable, or even conceivable—are not universally shared and are often informed by their embodiment as much as cognition. For example, fear of being scolded can inhibit overweight or obese individuals from seeking preventive healthcare, people with ‘invisible’ disabilities may feel pressured to pass as able-bodied to fit in, and Black individuals may avoid ordinary activities likely to prompt ‘birding while Black’ confrontations. Depicting cognition as the single site of judgment and decision-making therefore …

The Parliament Of Things: Shape-Changing Materials As Amplifiers Of Interspecies Relation Design, Yi Sui, Beatrice Bianco, Marinella Ferrara

DRS Biennial Conference Series

This paper explores shape-changing materials as agents of material diplomacy within More-than-Human Design. Drawing from Latour’s Parliament of Things, posthumanism, and new materialism, it investigates how responsive materials mediate ecological and interspecies relations. Through a multiple-case study approach, ten design projects are analyzed using a five-dimensional framework—environmental attunement, ecological flourishing, expressive vitality, co-existence and augmentation, and relational mediation. The analysis explores how these materials can perform communicative and political roles, positioning design as a diplomatic practice that negotiates shared concerns among species, technologies, and environments. It attempts to question extractivist models, support ecological repair, and cultivate forms of interspecies attentiveness. …

Design For Healthy Ageing: Developing And Applying A Resource Model, Yumei Dong, Hua Dong, Tingting Wang, Richard H. M. Goossens

DRS Biennial Conference Series

The sustainable development of an ageing society necessitates active participation of older people, requiring effective integration of their individual and collective resources into design. However, designers’ understanding of older people’s resources is rather limited. This study aims to develop a conceptual model of older people’s resources to support design for healthy ageing. Through literature review and interviews with 19 recently retired Dutch seniors, twelve resource types were identified, categorised into six dimensions: practical, emotional, intellectual, social, cultural, and time. These categories were synthesised into a Diamond Model of Resources. The framework, encompassing both resource categories and the Diamond Model, was …

Transitional Materialities, Sofia Soledad Duarte Poblete, Camilo Ayala-Garcia

DRS Biennial Conference Series

Transitional Materialities brings together research that understands materials not as static substances, but as dynamic agents embedded in ecological, technological, and socio-economic transitions. This perspective highlights the evolving relationship between material innovation, planetary health, and design’s capacity to mediate and guide change. The track explores how designers move beyond passive material selection to engage actively in experimentation, critical reflection, policy making and the development of alternative, resilient futures. Contributions address material inspiration, education, and archives as means to support knowledge sharing and open-access dissemination; they also map materials and practices across contexts, from rethinking traditional material values and local specificities …

Participatory Design As Emotional Infrastructure: Supporting Collective Reflection And Resilience After The Pandemic, Xinyu Zhang

DRS Biennial Conference Series

COVID-19 has left enduring emotional distress for many citizens even as public attention to the crisis has faded. In this context, participatory design (PD) is increasingly recognised as a dialogic and restorative practice that enables collective reflection and emotional recovery through shared meaning-making. This study examines how participatory design supports citizens in reflecting on pandemic-related psychological distress, with particular attention to war metaphors widely used in governmental and media communications during COVID-19. While these metaphors mobilised collective action, they also intensified perceptions of risk and vulnerability. The research is based on a year-long participatory design project, W&M, involving nine participants, …

Locality As A Driver For Transitional Materialities, Gökçe Deniz, Owain Pedgley, Camilo Ayala-Garcia

DRS Biennial Conference Series

Material designers worldwide are transforming how innovation emerges through local engagement, moving beyond conventional material selection to create materials that reflect and embody their originating contexts. This research examines how locality influences design motivations, resource utilisation, and collaborative approaches through a systematic analysis of 635 material design projects across 56 countries, complemented by questionnaire responses from 19 practitioners across 14 countries. The mixed-methods research establishes the state of the art by mapping ingredient sourcing patterns, fabrication processes, and stakeholder engagements across diverse geographical contexts, while illuminating designers' conceptual frameworks regarding the role of locality in material development. The research reveals …

A Hierarchical And Ontology-Based Taxonomy Of Stimuli–Smart Materials–Transformation Effects In 4d Printing As A New Interactive Modality, Jiayue Qin, Eujin Pei, Abdusselam Selami Cifter

DRS Biennial Conference Series

4D printing functions not merely as a smart manufacturing technique but as an interactive material technology: materials respond to human or environmental stimuli and generate a direct feedback loop. This study proposes a taxonomy that links Stimuli, Smart Materials, and Transformation Effects, developed through a combined Hierarchical Classification and Ontology-Based Classification approach grounded in a systematic literature review and ontology mapping. By organising complex stimulus–material–effect relationships into a designer-accessible structure, the taxonomy supports non-technical designers in identifying feasible pathways from intended interactions to material outcomes. It also provides a structured data foundation for developing 4D printing design guidelines and toolkits, …