Digital Commons Network^™

Smart-Biosense: Surface-Wave Molecular Aptamer-Based Recognition For Selective Whole-Cell Bacterial Detection, Eashan Selvarajah, Vikram Jangid

Interdisciplinary Design Senior Theses

One of the largest causes of food waste in the United States is recall or disposal of produce due to bacterial infection, with a prevalent cause being the pathogen Salmonella enterica Serovar Typhimurium. Current detection methods are inadequate for many use cases due to cost and speed of detection. In this paper, we propose and demonstrate a novel method of detecting the presence of S. Typhimurium quickly using a combination of aptamers and love-surface acoustic wave sensors. Our experiments demonstrate repeatable changes in sensor response during exposure to S. Typhimurium under test conditions. Our data shows a measurable difference in …

The Minutes Of The Marshall University Board Of Governors Meeting, June 10, 2026, Marshall University Board Of Governors

Board of Governors Minutes

No abstract provided.

Impact Of Maternal Covid-19 Infection Versus Vaccination On Mucosal Immunity In Breastmilk, Mymy Nguyen, Rupsa C. Boelig, Julie Jones, Wathsala Wijayalath, Gregory D. Gromowski, Zubair H. Aghai, Elke S. Bergmann-Leitner

Department of Obstetrics and Gynecology Faculty Papers

Background/Objectives: In the first months of their life, infants rely on maternal antibodies for immune protection. Breastmilk is a major source of these defenses, supplying secretory IgA, IgG, and IgM that help guard mucosal surfaces against pathogens such as SARS-CoV-2. Most studies on breastmilk immunity in the context of COVID-19 have emphasized circulating monomeric IgA, rather than the multimeric secretory IgA (sIgA) that is active at mucosal barriers. This study assessed in-depth the contribution of breastmilk antibody subtypes to SARS-CoV-2 neutralization capacity and how these profiles differ following maternal COVID-19 infection versus vaccination during pregnancy or postpartum.

Methods: …

The Effect Of Hunger On The Likelihood Of Glucose Excursions In Adults With Overweight Or Obesity: Continuous Glucose Monitoring And Ecological Momentary Assessment Observational Study, Byunggul Lim, Phrashiah Githinji, Yue Liao, Jacob Szeszulski, Alexandra L Macmillan Uribe, Rebecca A Seguin-Fowler, Jane Anderson, Chad D Rethorst

Faculty, Staff and Students Publications

Background: Maintaining stable glucose levels is important for metabolic health. Glucose excursions (GEs), which are marked increases in glucose following food intake, have been associated with a higher risk for cardiovascular disease and metabolic dysfunction. Individuals with overweight or obesity who do not have diabetes may still show impaired glucose regulation, as reflected in increased glucose variability. Hunger, as a real-time physiological cue, may be associated with subsequent glucose changes and represents a potential target for just-in-time adaptive interventions.

Objective: This study aimed to investigate the temporal relationship between self-reported hunger and subsequent glucose dynamics, including the likelihood of GE …

Immune Suppression And Metabolic Reprogramming In Bactrocera Dorsalis Parasitized By Fopius Arisanus, Rehemah Gwokyalya, Jeremy Herren, Thomas Ogao Onchuru, Sahadatou Mama Sambo, Cassandra Purity Ronnie, Ndlela Shepard, Sunday Ekesi, Samira A. Mohamed

All Peer-Reviewed Publications

Abstract – Bactrocera dorsalis is a major horticultural pest. Biocontrol using parasitoids, such as Fopius arisanus, is a sustainable tool for managing this pest. However, the mechanisms enabling the successful parasitism of B. dorsalis are poorly understood. Using transcriptomic profiling, cellular bioassays, and targeted metabolite analyses, we investigated how F. arisanus modulates the immunity and metabolic activity of B. dorsalis to achieve a high parasitism rate. Our results revealed a weak and late encapsulation response of B. dorsalis towards F. arisanus. Additionally, parasitism reduced the number of circulating haemocytes by 35%, lowered constitutive granulocyte counts and inhibited phenoloxidase activity in …

Neuroanatomical And Histological Insights Into Central Nervous System Abnormalities Of A 3-Year-Old With Progressive Encephalopathy, Lennox-Gastaut Syndrome, Micrencephaly, And Infantile Spasms, Haley Nation, Omid B. Rahimi, Rachel Morgan-Armbruster, Andrea R. Gilbert

The Journal of Integrative Physiology

Introduction: This case study presents a comprehensive neuroanatomical and histological analysis of the central nervous system from a 3-year-old donor with a rare complex neurological condition characterized by progressive encephalopathy, Lennox-Gastaut syndrome, micrencephaly, and infantile spasms. Method: This analysis was conducted using a combination of detailed gross dissection and histological examination to assess structural and neuronal abnormalities across multiple brain and spinal cord regions. External and internal analysis of the central nervous system revealed profound developmental and atrophic changes across various brain structures, including absent central sulci, abnormal gyration patterns, and severe cerebellar and cerebral atrophy. Key Findings: Key findings …

Polysomnographic And Clinical Characteristics Of Narcolepsy In Saudi Arabia: A 12-Year Retrospective Study, Banan Almalki, Omar Kanbr, Ghufran Bin Afeef, Shaimaa Hawsawi, Ranya Alshumrani, Faris Alhejaili, Siraj Wali

Saudi Medical Journal

Objective: To evaluate the clinical features, polysomnographic findings, and therapeutic outcomes of narcolepsy type 1 and type 2 patients in Kingdom of Saudi Arabia (KSA). Narcolepsy is a neurological condition marked by excessive daytime sleepiness (EDS) and associated symptoms, including cataplexy and disrupted nighttime sleep. Data on narcolepsy in KSA are still limited.

Methods: Forty-three patients diagnosed with narcolepsy from 2012 to 2024 were included in this retrospective study. Diagnosis followed the International Classification of Sleep Disorders criteria and incorporated clinical features, the epworth sleepiness scale (ESS), overnight polysomnography (PSG), and multiple sleep latency testing (MSLT). Data on demographics, clinical …

A Predictive Model For Cytomegalovirus Infection Using Routine Hematological And Biochemical Parameters: A Pilot Study, Ahmad A. Shaikh, Mofareh H. Alabdaly, Nabil A. Ageeli, Sultan Z. Alasmari, Adel M. Abo Mansour, Mohammed H. Makkawi

Saudi Medical Journal

Objective: To examine whether hematological and biochemical parameters assist in diagnosing cytomegalovirus (CMV) infections and differentiating between CMV-G and CMV-M. Cytomegalovirus causes distinct hematological changes that can serve as markers for diagnosis.

Methods: A retrospective analysis was conducted on 54 patients infected with CMV (25 CMV-G and 29 CMV-M) and 82 healthy controls. Age, gender, and routine hematological and biochemical parameters were evaluated. Receiver operating characteristics (ROC) analysis and logistic regression were used for data analysis.

Results: In comparison to controls, laboratory findings of patients with CMV-G revealed characteristic decreases in red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), and …

Safety And Efficacy Of Adalimumab Biosimilar In Psoriasis And Hidradenitis Suppurativa: A Clinical Experience, Raneem H. Najjar, Sarah O. Alrashid, Rnda F. Almahfouz, Hadeel T. Alzahrani, Majed Y. Aleissa, Alanoud R. Hakami

Saudi Medical Journal

Objectives: To evaluate the clinical experience, safety, and effectiveness of adalimumab biosimilars in patients with psoriasis and hidradenitis suppurativa.

Methods: We conducted a retrospective, single-center observational study between March and September 2024 using electronic medical records from King Abdulaziz Medical City and King Abdullah Specialized Children's Hospital, Riyadh, Saudi Arabia. Pediatric and adult patients with psoriasis or hidradenitis suppurativa who switched to adalimumab biosimilars between 2016 and 2022 were included. Variables included demographics, disease characteristics, prior therapies, biosimilar use, and adverse events.

Results: A total of 57 (93% adults; 50.9% female) patients were included. Obesity was present in 35.1%, and …

Molecular Mechanisms Of Diffuse Large B-Cell Lymphoma And The Complexities Of Tumor Development, Wael I. Alzahrani

Saudi Medical Journal

Diffuse large B-cell lymphoma (DLBCL), the most prevalent aggressive non-Hodgkin lymphoma, exhibits substantial molecular heterogeneity and arises from germinal center or post-germinal center B cells through recurrent genetic and epigenetic dysregulation of critical signaling pathways. Aberrations involving BCL6, MYC, MYD88, and components of B cell receptor and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κ B) signaling play central roles in lymphomagenesis, treatment resistance, and clinical outcomes. Gene expression profiling has defined major molecular subgroups in DLBCL, including germinal center B cell–like and activated B cell–like tumors, that show distinct pathogenesis and prognosis. High-risk entities, such as double- and …

Interleukin-6 Inhibition For Patients With Acute Myocardial Infarction: A Systematic Review And Meta-Analysis, Mohammed Y. Alasmary, Mohammed J. Almalki, Faisal H. Almalki, Waleed D. Khubzan, Mohammed H. Rajab, Mohammed S. Almalki, Hussam A. Almalki, Omar M. Alsuwat, Hussam M. Alghannami

Saudi Medical Journal

Objective: To explore the outcomes associated with interleukin-6 (IL-6) pathway blockade, using tocilizumab, in patients with ST-elevation myocardial infarction (STEMI) and non (NSTEMI). Acute myocardial infarction (AMI) denotes myocardial necrosis due to ischemia and presents in distinct electrocardiographic phenotypes. Inflammation driven by IL-6 contributes to ischemia-reperfusion injury, with tocilizumab showing promise in reducing myocardial damage and improving outcomes.

Methods: This work followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Framework and was registered in international prospective register of systematic reviews (PROSPERO). Relevant studies were identified through structured searches of PubMed, MEDLINE, the Cochrane Library, and Google Scholar up …

Cure Sickle Cell Initiative Recommendations On Common Data Elements For Sickle Cell Disease Gene Therapy Trials, Sophie Lanzkron, Victoria H. Coleman-Cowger, Alexis A. Thompson, C. Patrick Carroll, Traci Clemons, Michael Debaun, Julie Kanter, Punam Malik, Deepa Manwani, Francis John Pierciey, Mark C. Walters, Sherita Alai

Cardeza Foundation for Hematologic Research

The Cure Sickle Cell Initiative (CureSCi), created by the National Heart, Lung, and Blood Institute, has developed data standards to increase interoperability and meta-analysis of studies specifically investigating gene therapy for sickle cell disease (SCD). The aims of the CureSCi Common Data Elements (CDE) initiative are to facilitate the development of safe, effective, and accessible gene therapies. Five working groups (WGs) comprising people living with SCD, stakeholders, clinicians, and researchers reviewed current definitions used for SCD clinical studies, including those from the American Society of Hematology, US Food and Drug Administration, PhenX catalog of consensus measures for phenotypes and exposures, …

U.S. Black Men’S Perceptions Of The Similarities And Interplay Among Mind-Body Practices, Spirituality, And Religion: A Qualitative Study, Khanh Pham

Theses and Dissertations

This qualitative study explored U.S. Black men’s perceptions of relations among mind-body practices (MBPs), spirituality, and religion to understand how these factors might influence Black men’s health. Reflexive thematic analysis was used to analyze data from individual semi-structured interviews with 18 Black male MBP instructors. Five themes were generated. The themes were (1) spirit(uality) is the foundation for Black men’s experience of life seen and unseen, (2) MBPs and religion are rooted in spirituality, (3) MBPs, religion, and Black culture share common characteristics, (4) MBPs and religion facilitate holistic wellbeing, and (5) confusion and negative perceptions about MBPs, spirituality, and …

Automated Detection Of Bacterial Flagellar Motors, Eben J. Lonsdale

Undergraduate Honors Theses

With advances in cryogenic electron tomography, the ability to study bacterial structures in their cellular context has improved. However, 3D images of bacteria, called tomograms, have a low signal-to-noise ratio. This makes annotating structures of interest difficult, as traditional computer vision models struggle with tomograms and manual annotation is time consuming. We build on the results of the BYU Kaggle competition to create an ensemble model capable of automatically annotating flagellar models with nearly around 85% accuracy.

Methylglyoxal And Glyoxal In High-Puff Disposable Electronic Cigarette Liquids: Unexpected Accumulation And Enhanced Cytotoxicity, Esther E. Omaiye, Wentai Luo, Kevin J. Mcwhirter, Man Wong, Prue Talbot

Civil and Environmental Engineering Faculty Publications and Presentations

Despite concerns regarding the potential health risks associated with EC use, their design, puff count, and e-liquid formulations have continued to evolve. Aldehydes are a key class of thermal degradation byproducts generated during the vaporization of EC fluids. This study tested the hypothesis that aldehyde concentrations would be elevated in used ECs with high puff numbers. Devices from multiple brands were analyzed to assess the impact of extended use on aldehyde formation. E-fluids were extracted from field-collected and user-donated devices and analyzed using gas chromatography/mass spectrometry to quantify 178 flavor chemicals, two synthetic coolants, nicotine, solvents, and aldehydes (methylglyoxal (MGO), …

Export Controls Policy & Procedure, Munster Technological University, Ireland

Policies & Procedures Documents

The aim of this document is to ensure the University meets its legal obligations under export controls and sanctions legislation, seeking to protect the University and its community from the risks of non-compliance, while supporting secure and responsible international collaboration and research.

Uranyl Complex Of 1,3-Bis(Ditertbutylphosphinoxidomethyl)Benzene, Maha M. Alotaibi, Md Abdul Goni, Eric Reinheimer, Tasneem A. Siddiquee

Chemistry Faculty Research

This short note presents a new molecule isolated and characterized from the reaction of uranyl nitrate with the PCP-type pincer ligand 1,3-bis(ditertbutylphosphinomethyl)benzene in the presence of UV light under ambient conditions. The new dinuclear uranyl-PCP complex was characterized by using FT-IR spectroscopy and single-crystal X-ray crystallography. As revealed by the crystal structure, the new complex had oxygen atoms coordinating from the phosphinoxides that were oxidized under ambient conditions. Each uranium atom of this dinuclear complex was found to exhibit pentagonal bipyramidal coordination geometry.

Teachers' Promoting Literacy Achievement For Middle School African American Male Students, Angelia Slavings

Walden Dissertations and Doctoral Studies

No abstract provided.

Transformative Practices: The Multiple Impacts Of The Mat Program At Al-Quds Bard College, Daniel Terris, Derek Furr

GHEA21 Open Educational Resources

This paper summarizes research on the impact of the Master of Arts in Teaching (MAT) program at Al-Quds Bard College, which since 2009 has trained more than 600 Palestinian K-12 teachers working across the West Bank and reaching over 120,000 students, many in disadvantaged communities. Supported in part by the Education Above All foundation, the program combines educational theory, discipline-based knowledge, classroom research, and reflective practice, requiring in-service teachers to experiment with new teaching approaches in their own classrooms. Multiple studies reviewed in the paper show that MAT graduates adopt more student-centered pedagogies—such as backward design, inquiry-based learning, and collaborative …

The Psychosocial Factors Influencing Hiv Testing Among Women In Ghana, Janet Okailey Okine

Electronic Theses and Dissertations Archive

HIV testing is still an important component of HIV prevention, and disparities persist among women in Ghana. This study examines psychosocial and socio-demographic factors influencing HIV testing behavior, using data from the 2022 Ghana Demographic and Health Survey. A binary logistic regression result revealed that older, more educated, and wealthier women, and women who utilized HIV test kits, exhibit a much higher likelihood of undergoing HIV testing. Awareness of HIV stigma reduces the likelihood of women undergoing testing. Variations existed depending on the place of residence. Women in rural and northern belts were less likely to undergo testing. Marital status, …

“Your ‘Magic Dick’ Won’T Fix Us”: The Lived Experience Of Women With Vaginismus, Alisun Fiona Hughes

Electronic Theses and Dissertations Archive

Genito-Pelvic Pain/Penetration Disorder, or what is commonly referred to as Vaginismus, is a pelvic floor dysfunction which causes penetration of the vagina to be painful or impossible. This qualitative study examines the lived experiences of women living with vaginismus, looking specifically at how they were socialized to perceive sex and how they navigate their condition. Grounded in theories such as Sexual Scripts Theory, Stigma Theory and Gender as Performance, this research analyzes how this condition is not just a biological trait, but also a socialized phenomenon that often causes a “spoiled identity”. Data was collected through an open-ended online survey …

2026-06-09 Minutes, Morehead State University. Staff Congress.

Staff Congress Records

Staff Congress meeting minutes from June 9, 2026.

Ora (Oneball Robotic Arm), Isabella Murillo, Juan Pablo Fernandez Garza, Gabriel Kotab, Catherine Epstein

Electrical and Computer Engineering Senior Theses

Confined spaces are dangerous and awkward to navigate environments, often putting those who work in them at risk. To reduce effort and human exposure to these hazards, robotic systems can be used to navigate and inspect these areas to limit, or even eliminate the need for human presence in confined spaces. This project proposes an autonomous robot that can navigate confined spaces while sending data back to the user. The robot features a spherical body that is capable of a zero rotational axis, with an external, magnetically attached head. This head contains scanners or tools that the user can remotely …

The Technology Of Tradition And Biology Of Narrative: New Analogies For The Study Of Homer And Epic, Eunice Kim

Open Access Fund Publications

In two separate, timely books Bozzone and Christensen draw from a wide range of scientific disciplines and modern parallels to consider how Homeric language and epic stories are in some ways living and alive. For Bozzone, who analyses the various formal features of Homer’s poetic technique by incorporating cognitive and linguistic frameworks, Homeric language is ‘living’ insofar as it operates on mechanisms analogous to those a speaker uses for natural languages and other kinds of speaking performances. Christensen, on the other hand, applies a series of biological analogies to epic poetry and imagines that the narrative of Homeric epic is …

Trauma-Informed Conversational Agents For Mental Health: Understanding User Perspectives And Experiences, Xintong Lu, Shion Guha, Rachel Pfafman, Jessica Pater, Courtney L. Washington, Fayika Farhat Nova

Health Services and Informatics Research

Introduction:

Mental health conversational agents (MHCAs) offer scalable, accessible psychological support yet raise concerns about safety and appropriateness for trauma, exposed users. While trauma-informed care (TIC) principles, emphasizing safety, trust, empowerment, collaboration, peer support, and cultural sensitivity, are well-established in clinical practice, their application and user interpretation in chatbot contexts remain unexplored. This study aimed to explore (1) how users conceptualize trauma-informed care in the context of mental health chatbots and (2) what factors can help us predict whether users perceive their chatbot interaction as trauma-informed.

Methods:

A 59-item web-based survey (REDCap) assessed demographics, technology proficiency, adverse life experiences, chatbot …

Maximizing Room-Temperature Red Phosphorescence In Contorted Hexabenzocoronene Derivatives, Marko R. Ivancevic, Moses D. Ogbaje, Jesse A. Wisch, Daniel G. Oblinsky, Alice S. Fergerson, Emily C. Davidson, Gregory D. Scholes, Barry P. Rand, Chad Risko, Quinn C. Burlingame, Yueh Lin Loo

Chemistry Faculty Publications

Organic molecules exhibiting second-scale room-temperature phosphorescence (RTP) in the red/near-infrared are particularly rare because low-energy excited states that are characteristic of these chromophores are susceptible to nonradiative deactivation. Here, we observe second-scale red RTP from contorted hexabenzocoronene (cHBC) embedded in a rigid polymer. This RTP is uniquely efficient as approximately 23% of the steady-state photoluminescence originates from triplets. We propose that this efficient triplet generation stems from intersystem crossing (ISC) that outcompetes symmetry-forbidden fluorescence. Density functional theory and time-dependent density functional theory calculations suggest that ISC occurs from the lowest energy singlet state of cHBC into a nearly resonant triplet …

Publisher Correction: Whole Genome Sequence Analysis Of Pulmonary Function And Copd In 44,287 Multi-Ancestry Participants, Wonji Kim, Xiaowei Hu, Kangjin Kim, Sung Chun, Peter Orchard, Dandi Qiao, Ingo Ruczinski, Aabida Saferali, Francois Aguet, Lucinda Antonacci-Fulton, Pallavi P Balte, Traci M Bartz, Wardatul Jannat Anamika, Xiaobo Zhou, Junyi Duan, Jennifer A Brody, Brian E Cade, Martha L Daviglus, Harshavadran Doddapaneni, Shannon Dugan-Perez, Susan K Dutcher, Christian D Frazar, Stacey B Gabriel, Sina A Gharib, Namrata Gupta, Brian D Hobbs, Silva Kasela, Laura R Loehr, Ginger A Metcalf, Donna M Muzny, Elizabeth C Oelsner, Laura J Rasmussen-Torvik, Colleen M Sitlani, Joshua Smith, Tamar Sofer, Hanfei Xu, Bing Yu, David Zhang, John Ziniti, R Graham Barr, April P Carson, Myriam Fornage, Lifang Hou, Ravi Kalhan, Robert Kaplan, Tuuli Lappalainen, Stephanie J London, Alanna C Morrison, George T O'Connor, Bruce M Psaty, Laura M Raffield, Susan Redline, Stephen S Rich, Jerome I Rotter, Edwin K Silverman, Ani Manichaikul, Michael H Cho

Faculty, Staff and Student Publications

This corrects the article "Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants", 28.

Agrivoltaic Shading Reduces Soil Greenhouse Gas Fluxes In A Semi-Arid Vineyard, Marcelo Gomes Da Silva, Rafael M. Almeida, Carine Cocco, Engil Pereira

School of Earth, Environmental, & Marine Sciences Faculty Publications

Agrivoltaic systems are expanding in semi-arid regions, raising questions about how panel driven shading alters soil greenhouse gas exchange. We used automated chambers to measure high frequency soil CO2, N2O, and CH4 fluxes in a newly established vineyard agrivoltaic system in Texas across three shading intensities (0%, 35%, 88%) that represent the light environment beneath panels as shaped by panel tilt and solar trajectory. Shading primarily cooled the soil, reducing mean soil temperature from 35.9 °C (0%) to 32.5 °C (35%) and 30.5 °C (88%), while mean soil water content shifted modestly (0.125, 0.106, and 0.130 m3 m−3, respectively). Over …

The Effect Of Face Masks On The Perception Of Trustworthiness And Competence In Individuals With Autistic Traits, Farid Pazhoohi, Maryam Rostami-Aghoui, Leilani Forby, Keina Aoki, Alan Kingstone

School of Psychology

Facial expressions play a crucial role in social communication, influencing judgments of trustworthiness and competence. While previous research has examined how face masks affect trust and competence in general populations, little is known about their impact on individuals with high autistic traits, who often rely more on the mouth region for social cue interpretation. The present study investigates the effects of face masks on perceptions of trustworthiness and competence as a function of high and low autistic traits. Results show that masked faces are generally perceived as more trustworthy and competent than unmasked faces. The effect of mask wearing on …

Decorin Promotes Nascent Proteoglycan Retention In Cartilage Matrix By Strengthening Collagen Ii-Aggrecan Integration, Thomas Li, Gabriela Canziani, Yuchen Liu, Neil Patel, Biao Han, Mingyue Fan, Annie Porter, Bryan Kwok, Chao Wang, Qing Li, David E. Birk, Renato V. Iozzo, Irwin M. Chaiken, X. Lucas Lu, Robert L. Mauck, Lin Han

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Cartilage extracellular matrix (ECM), a hydrated collagen II-aggrecan composite, undergoes dynamic turnover during both normal homeostasis and disease-associated remodeling. This study elucidates a crucial role for decorin in promoting the retention and stability of nascent aggrecan within this matrix. By applying bio-orthogonal click-labeling, we demonstrate that loss of decorin accelerates the release of nascent aggrecan under both physiological and inflammatory conditions, without affecting its preferential localization to the pericellular matrix. Conversely, supplementation with exogenous decorin mitigates inflammation-induced loss of nascent aggrecan, supporting its potential as a therapeutic target. At the molecular level, decorin exhibits strong binding affinity for aggrecan, and …