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Articles 1891 - 1920 of 18233
Full-Text Articles in Entire DC Network
A Comparison Of Survival, Growth, And Stress Resilience In Three Different Lineages Of The Pacific Oyster (Crassostrea Gigas) Farmed On The California Central Coast, Victoria F. Hanshaw
A Comparison Of Survival, Growth, And Stress Resilience In Three Different Lineages Of The Pacific Oyster (Crassostrea Gigas) Farmed On The California Central Coast, Victoria F. Hanshaw
Master's Theses
Aquaculture of Pacific oysters on the US West Coast is routinely impacted by seasonal unexplained mortality events. To better understand these large-scale mortality events in oyster aquaculture, shellfish growers and scientists in California have partnered together to conduct comparative, multi-estuary farm trials of discrete Pacific oyster (Crassostrea gigas) lineages. In this thesis we investigate how the more recently imported Midori lineage performs compared to the historically used Miyagi lineage, as well as a Hybrid (Midori x Miyagi) lineage. As part of a 7-month long field study from April-November of 2024 in Morro Bay and Tomales Bay, California, we evaluated …
The Effect Of Specialty Malt On Dry-Hopping, Alexander Kivela
The Effect Of Specialty Malt On Dry-Hopping, Alexander Kivela
Master's Theses
Dry-Hopping is a modern and ever-increasing method to add hoppy flavors to beer. This is typically seen in pale ales and India Pale Ales (IPA’s). Most research has investigated the effect of dry-hopping only using pale malt, whereas most breweries used specialty malts to create a malty backbone to their beer.
The objectives of this research were to analyze the impact of specialty malts and their concentration on the efficacy of hop flavor and extraction, determined via gas chromatography and sensory analysis. Gas chromatography analysis was modeled after the ASBC Method Beer-48. Sensory analysis was performed via the 15cm line …
Hardware-In-The-Loop Evaluation Of Sensor-Source Selection For Prosthetic Locomotion Intent Recognition, Victoria Asencio-Clemens
Hardware-In-The-Loop Evaluation Of Sensor-Source Selection For Prosthetic Locomotion Intent Recognition, Victoria Asencio-Clemens
Master's Theses
Active lower-limb prostheses use intent-recognition systems to identify a user’s locomotion mode and select an appropriate control strategy, but sensor configurations that perform well offline may be unsuitable for resource-constrained embedded hardware. Existing sensor-selection methods generally prioritize classification accuracy without directly accounting for processing latency, memory usage, or other hardware-dependent requirements. To address this limitation, this thesis develops a hardware-in-the-loop source-selection framework for embedded classification of level walking, ramp ascent, ramp descent, stair ascent, and stair descent using multimodal biomechanical data from transtibial amputee participants. Subject-specific linear support vector machine classifiers were evaluated using trial-held-out validation, and candidate configurations from …
Predicting Student Belonging In Computing Education: A Multimodal Machine Learning Approach Using Eeg And Survey Data, Hannah Moshtaghi
Predicting Student Belonging In Computing Education: A Multimodal Machine Learning Approach Using Eeg And Survey Data, Hannah Moshtaghi
Master's Theses
Measuring students’ sense of belonging, characterized by feelings of acceptance, inclusion, and encouragement from teachers, remains a significant challenge in computing education. Prior research has associated this multidimensional construct with positive academic outcomes and has identified instructors’ growth- and fixed-mindset messaging as a potential influence. However, belonging is a complex and deeply personal experience that is difficult to capture through direct observation alone. Current measurement methods rely on self-report surveys, which may not capture every aspect of an experience that can also involve emotional and cognitive responses.
This thesis investigates whether combining EEG data recorded during a belonging questionnaire with …
Impact Of Repeated Serotonin 6 Receptor Activation On Weight And Anxiety In C57bl/6j And Btbr Mice, Pedro Flores
Impact Of Repeated Serotonin 6 Receptor Activation On Weight And Anxiety In C57bl/6j And Btbr Mice, Pedro Flores
Electronic Theses, Projects, and Dissertations
Selective Serotonin Reuptake Inhibitors (SSRI) are the most common form of medication prescribed to people with anxiety disorders. One of the most common side effects is weight gain. This weight gain often leads to the suspension of treatment. This has led to studies focusing on specific serotonin (5-HT) receptor targets for modulating depression and anxiety. Studies examining 5-HT6 antagonist treatment have shown that they reduce body weight as well as produce brain specific changes. Less is known regarding 5-HT6 receptor agonists, although previous literature has shown that exposure to high doses produces weight loss but not at lower doses, while …
Comparative Assessment Of Developmental Fidelity In Hpsc-Derived Neural Crest Cells, Michael H. Zepeda
Comparative Assessment Of Developmental Fidelity In Hpsc-Derived Neural Crest Cells, Michael H. Zepeda
Electronic Theses, Projects, and Dissertations
Neural crest cells (NCCs) are a transient, multipotent cell population that contributes to craniofacial structures, peripheral neurons, melanocytes, and smooth muscle. Defects in NCC development underlie a broad range of congenital disorders known as neurocristopathies. Human pluripotent stem cell (hPSC)-derived NCCs provide an evaluable model for studying early human development; however, existing differentiation protocols produce variable outcomes, and no standardized method consistently generates high-fidelity NCC populations. To address this challenge, we compared five published hPSC-to-NCC differentiation protocols using the H9 human embryonic stem cell line. We hypothesized that specific protocols more faithfully recapitulate neural crest development through coordinated regulation of …
How Establishing "Duration Of Treatment" Guidelines Shortens Workers' Compensation Cases, Annette Marie Smith M.D.
How Establishing "Duration Of Treatment" Guidelines Shortens Workers' Compensation Cases, Annette Marie Smith M.D.
Electronic Theses, Projects, and Dissertations
Jobs provide financial security for individual workers and their families in the community until a worker gets hurt on the job, and then things are up in the air until their workers’ compensation claim is approved. It is a well-known fact within the workers compensation literature that one third of all workers’ compensation (WC) claims are “low back sprains and strains” which are the leading cause of global disability (Ummey, 2023). This project proposed to explore the relationship of x-ray and MRI result interpretations by the physician and standardize the duration of treatment with a physical therapist and new concept …
Genocide As Patriotic Duty: The Outcomes Of Ultranationalism And Dehumanization From World War Ii Genocide Orchestrators, Corie R. Blais
Genocide As Patriotic Duty: The Outcomes Of Ultranationalism And Dehumanization From World War Ii Genocide Orchestrators, Corie R. Blais
Electronic Theses, Projects, and Dissertations
The thesis provides a contribution to the field of history how nationalism
often transforms individuals during wartime to become dehumanizing
ultranationalists through patriotism and its connection to genocide. Also, it gives
insight into the many ways that genocide orchestrators during World War II,
relied on propaganda of racism, religion, and “othering” in order to justify their
incentives to expand territories and dehumanize victims through medical
experimentations and sexual violence. While research materials in the context of
Nazi Germany were ample, one challenge in my research was finding
documentations on Stalin’s People Commissariat of Internal Affairs (NKVD)
police unit which carried …
From Genes To Streams: Mitochondrial Approaches To Population Monitoring Of The Santa Ana Sucker Catostomus Santaanae, Mariana Antonio
From Genes To Streams: Mitochondrial Approaches To Population Monitoring Of The Santa Ana Sucker Catostomus Santaanae, Mariana Antonio
Electronic Theses, Projects, and Dissertations
This study was developed to use aquatic environmental DNA (eDNA) as a tool to detect the presence of the Santa Ana sucker (Catostomus santaanae), a federally threatened fish species, across the Santa Ana River in Southern California. Environmental DNA is any genetic material that an organism sheds into the environment. We can get an idea of what aquatic species are present when sampling water at a given site. We sequenced the complete mitochondrial genome (mitogenome) of the Santa Ana sucker and designed custom DNA primers to improve eDNA detection accuracy. These primers were selected based on high genetic …
The Third Zone Of Incomplete Rights: Spatial Compartmentalization, Expendability, And The Making Of Death Worlds In Adichie's Dream Count, Ebelenna F. Nwaobi
The Third Zone Of Incomplete Rights: Spatial Compartmentalization, Expendability, And The Making Of Death Worlds In Adichie's Dream Count, Ebelenna F. Nwaobi
Research Papers
Contemporary socio-political discourses on global migration often risk misrepresenting migrant experiences by framing them mainly through the language of humanitarianism, inclusion, and identity. While these frameworks foreground protection and belonging, they may inadvertently obscure the institutional and political structures that regulate, differentiate, and expose migrants to uneven forms of precarity. In this paper, therefore, I examine Chimamanda Ngozi Adichie's Dream Count to explore the migrant condition as one shaped by migrants’ everyday encounters with space, law, labor, and political belonging. By so doing, I argue that the novel reveals migrant vulnerability not just as the consequence of singular acts of …
Srividhya Ragavan, Srividhya M. Ragavan
Asm And A Culture Of Sharing, Caring, And Fun In Education, David J. Westenberg
Asm And A Culture Of Sharing, Caring, And Fun In Education, David J. Westenberg
Biological Sciences Faculty Research & Creative Works
One doesn't always equate a professional scientific society with sharing, caring, and fun, but in this age of public distrust, public engagement with science and active student learning are ways to regain trust. ASM holds a leadership position in promoting and recognizing the value of education in the future of our profession and is there to support your educational journey. From K12 outreach and public engagement, to professional development, to presenting and publishing scholarship of teaching and learning, ASM has been at the forefront of biology education. Under the leadership of visionary directors such as Amy Chang and now Irene …
Analyzing The Effects Of Biodegradable Plastic Fragments On Maize Development And Defense Signaling, Ulysses Hampton
Analyzing The Effects Of Biodegradable Plastic Fragments On Maize Development And Defense Signaling, Ulysses Hampton
Theses
As plastic use shifts from non-degradable to biodegradable materials, the effects of biodegradable plastic fragments on crop physiology remain unclear. This study investigated how biodegradable plastic fragments influence maize development, transpiration, and defense signaling. Among five plastic types tested, poly(butylene adipate-co-terephthalate) (PBAT), polyhydroxyalkanoates (PHA), polycaprolactone (PCL), polylactic acid (PLA), and thermoplastic starch (TPS). PBAT and TPS showed the most significant effects and were selected for further oxylipin analysis. Results indicate that biodegradable plastic fragments can alter oxylipin signaling pathways in subtle but meaningful ways, suggesting that these materials are not inherently risk-free alternatives to conventional plastics.
'Fast' And 'Slow' Water Handling Strategies Explain Pinyon Pine Decline And Juniper Expansion, M. Faraz Rehman
'Fast' And 'Slow' Water Handling Strategies Explain Pinyon Pine Decline And Juniper Expansion, M. Faraz Rehman
All Graduate Theses and Dissertations, Fall 2023 to Present
Across the western United States, pinyon and juniper woodlands are changing with pinyon pine trees dying back while juniper becoming more abundant. Previous studies suggested that pinyon may lose more water during drier periods. But water loss is only part of the story. Water inputs, or how plants absorb water, are also likely to be important, but rarely well understood. To better understand this, we measured how pinyon and juniper absorb water from different soil depths and how actively they lose water through their leaves. Measurements were made over two years at three sites that ranged from more dry to …
The Evolution Of Hymenopteran Recombination Rates, Timothy John Delory
The Evolution Of Hymenopteran Recombination Rates, Timothy John Delory
All Graduate Theses and Dissertations, Fall 2023 to Present
Individuals of some species mix their DNA frequently when producing sex cells, while others do so much less. Hymenopterans (ants bees and wasps) are especially useful for understanding this variation for several reasons. They show large differences in this frequency of shuffling, or rate of recombination, have well-studied genomes, and vary widely in how they live and reproduce. I capitalized on these features examines how recombination rates have evolved in this group at the trait, and gene level.
First, I revisited long-standing ideas about why recombination rates differ among these species, incorporating more than a decade of new research. This …
Fibrous Protein Biomaterials: Characterization Of Solitary Bee Silk And Cocoons, And Development Of Recombinant Hagfish And Bee Silk Materials, Oran Wasserman
Fibrous Protein Biomaterials: Characterization Of Solitary Bee Silk And Cocoons, And Development Of Recombinant Hagfish And Bee Silk Materials, Oran Wasserman
All Graduate Theses and Dissertations, Fall 2023 to Present
This dissertation explores two complementary aspects of fibrous protein biomaterials: the characterization of understudied naturally occurring solitary bee silk and cocoons; and recombinant expression and biomaterial formation of recombinant hagfish intermediate filaments (rHIF) and a single Osmia lignaria Say (Hymenoptera: Megachilidae) silk protein. Some solitary bee species, which make up about 75% of all bee species, spin silk to construct protective cocoons during development. Despite the importance of silk and cocoons to the solitary bees' life history, their properties remain largely unexplored. This dissertation presents a novel method for isolating and testing individual silk fibers without interfering with the development …
Proteomic Signatures Of 3-Year Progression From Impaired Fasting Glucose To Diabetes: The Atherosclerosis Risk In Communities (Aric) Study, Mary R Rooney, Justin B Echouffo Tcheugui, Jingsha Chen, Keenan A Walker, Christie M Ballantyne, Eric Boerwinkle, Tanika N Kelly, Chiadi E Ndumele, James S Pankow, Morgan E Grams, Wendy S Post, Peter J Ganz, Alexis C Wood, Jerome I Rotter, Elizabeth Selvin, Josef Coresh
Proteomic Signatures Of 3-Year Progression From Impaired Fasting Glucose To Diabetes: The Atherosclerosis Risk In Communities (Aric) Study, Mary R Rooney, Justin B Echouffo Tcheugui, Jingsha Chen, Keenan A Walker, Christie M Ballantyne, Eric Boerwinkle, Tanika N Kelly, Chiadi E Ndumele, James S Pankow, Morgan E Grams, Wendy S Post, Peter J Ganz, Alexis C Wood, Jerome I Rotter, Elizabeth Selvin, Josef Coresh
Faculty, Staff and Students Publications
Objective: To identify proteomic signatures underlying 3-year progression from impaired fasting glucose (IFG) to diabetes.
Research design and methods: We examined IFG progression in the Atherosclerosis Risk in Communities (ARIC) study from visit 2 (1990-1992) to visit 3 (1993-1995). We tested associations of 4,955 plasma proteins (SomaScan version 4.0) with ∼3-year progression from IFG (FG 100-125 mg/dL without diabetes) to diabetes (diagnosis, medication, or FG ≥126 mg/dL) using logistic regression models adjusted for demographics, cardiometabolic risk factors, and baseline glucose with Bonferroni correction (P < 10-5). We explored biological pathways enriched among the top proteins and calculated improvements in prediction (ΔAUC and net reclassification using 3-year risk thresholds of 6% and 15% in 80% training and 20% internal validation subsamples). We validated results in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.
Results: There were 3,786 ARIC participants with IFG (mean [SD] age 57 [6] years, 52% female, …
Pelagic Ecosystem Interactions Of An Offshore Longline Mussel Farm, Llucia Mascorda-Cabre, Philip Hosegood, Martin Attrill, Emma Sheehan
Pelagic Ecosystem Interactions Of An Offshore Longline Mussel Farm, Llucia Mascorda-Cabre, Philip Hosegood, Martin Attrill, Emma Sheehan
School of Biological and Marine Sciences
Long-term interactions of the UK's first large scale offshore mussel farm with the surrounding pelagic environment were studied to assess the farm's ecological impact. Pelagic fishes, zooplankton community and oceanographic parameters such as temperature, salinity, density, chlorophyll- α, dissolved oxygen and CDOM were quantified over seven years. Effects to oceanographic parameters were observed locally comparing samples collected on the east and west parts of the farm, evidencing turbulent mixing of the water column enhanced by the farm. There was no difference between zooplankton assemblage composition inside and outside the farm, only naturally occurring temporal changes were detected, supporting the hypothesis …
Tidally Driven Topographic Eddies Exploited By Manta Feeding Aggregations, Harvey Cairns, Daniel Conley, Christopher Stokes, Tim Scott, Philip Hosegood
Tidally Driven Topographic Eddies Exploited By Manta Feeding Aggregations, Harvey Cairns, Daniel Conley, Christopher Stokes, Tim Scott, Philip Hosegood
School of Biological and Marine Sciences
The seasonal feeding aggregations of reef manta rays (Mobula alfredi) in Hanifaru Bay, Maldives, are the largest known of their kind, yet the mechanisms facilitating this phenomenon remain poorly understood. Understanding these drivers is crucial for effective conservation and management, as protecting key foraging habitats requires knowledge of the physical processes influencing prey availability. While previous studies highlight the role of zooplankton in attracting manta, the oceanographic mechanisms responsible for concentrating prey within the bay remain hypothesised but unproven. Specifically, the influence of eddy dynamics, tidal forcing, and regional circulation on zooplankton distribution has not been thoroughly examined.A …
Colocalization Of Eqtls With Type 2 Diabetes And Glycemic Traits Using Whole-Genome Sequences In Diverse Populations From The Nhlbi Trans-Omics In Precision Medicine (Topmed) Program, Ningyuan Wang, Daniel A Dicorpo, Yixin Zhang, Erica Kleinbrink, Donna K Arnett, John Barnard, John Blangero, Donald W Bowden, April P Carson, Yii-Der Ida Chen, Mina K Chung, Joanne E Curran, Dawood Darbar, Ravindranath Duggirala, Patrick T Ellinor, Diane Fatkin, Myriam Fornage, Nancy Heard-Costa, Jiang He, Lifang Hou, Sharon L R Kardia, Charles Kooperberg, Ruth J F Loos, David D Mcmanus, Braxton D Mitchell, Ryan L Minster, Kari E North, Bruce M Psaty, Laura M Raffield, Susan Redline, Stephen S Rich, Dan Roden, Jerome I Rotter, Moore B Shoemaker, Jonathan D Smith, David R Van Wagoner, Francois Aguet, Kristin Ardlie, Joshua C Bis, Jennifer A Brody, Brian E Cade, Clary B Clish, Paul S De Vries, James S Floyd, Barry I Freedman, Stacey Gabriel, Robert E Gerzsten, Mark O Goodarzi, Charles Gu, Xiuqing Guo, Namrata Gupta, Susan R Heckbert, Sarah Hsu, Yi-Jen Hung, Rita R Kalyani, Tanika N Kelly, Gregory L Kinney, Changwei Li, Simin Liu, Yongmei Liu, Donald M Lloyd-Jones, Joann E Manson, Rasika A Mathias, Josep M Mercader, Alanna C Morrison, Take Naseri, Suna Onengut, Nicholette D Palmer, Patricia A Peyser, Qibin Qi, Sridharan Raghavan, Alex P Reiner, Mary R Rooney, Magdalena Sevilla-Gonzalez, Chloe Sarnowski, Joshua D Smith, Jennifer A Smith, Nicole L Spartano, Usman Tahir, Kent D Taylor, Deirdre K Tobias, Russel P Tracy, Satupa'itea Viali, Heming Wang, Alexis C Wood, Lisa R Yanek, Wei Zhao, Yinan Zheng, Josée Dupuis, Ching-Ti Liu, Robert Sladek, Jennifer Wessel, James B Meigs, Alisa K Manning, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium
Colocalization Of Eqtls With Type 2 Diabetes And Glycemic Traits Using Whole-Genome Sequences In Diverse Populations From The Nhlbi Trans-Omics In Precision Medicine (Topmed) Program, Ningyuan Wang, Daniel A Dicorpo, Yixin Zhang, Erica Kleinbrink, Donna K Arnett, John Barnard, John Blangero, Donald W Bowden, April P Carson, Yii-Der Ida Chen, Mina K Chung, Joanne E Curran, Dawood Darbar, Ravindranath Duggirala, Patrick T Ellinor, Diane Fatkin, Myriam Fornage, Nancy Heard-Costa, Jiang He, Lifang Hou, Sharon L R Kardia, Charles Kooperberg, Ruth J F Loos, David D Mcmanus, Braxton D Mitchell, Ryan L Minster, Kari E North, Bruce M Psaty, Laura M Raffield, Susan Redline, Stephen S Rich, Dan Roden, Jerome I Rotter, Moore B Shoemaker, Jonathan D Smith, David R Van Wagoner, Francois Aguet, Kristin Ardlie, Joshua C Bis, Jennifer A Brody, Brian E Cade, Clary B Clish, Paul S De Vries, James S Floyd, Barry I Freedman, Stacey Gabriel, Robert E Gerzsten, Mark O Goodarzi, Charles Gu, Xiuqing Guo, Namrata Gupta, Susan R Heckbert, Sarah Hsu, Yi-Jen Hung, Rita R Kalyani, Tanika N Kelly, Gregory L Kinney, Changwei Li, Simin Liu, Yongmei Liu, Donald M Lloyd-Jones, Joann E Manson, Rasika A Mathias, Josep M Mercader, Alanna C Morrison, Take Naseri, Suna Onengut, Nicholette D Palmer, Patricia A Peyser, Qibin Qi, Sridharan Raghavan, Alex P Reiner, Mary R Rooney, Magdalena Sevilla-Gonzalez, Chloe Sarnowski, Joshua D Smith, Jennifer A Smith, Nicole L Spartano, Usman Tahir, Kent D Taylor, Deirdre K Tobias, Russel P Tracy, Satupa'itea Viali, Heming Wang, Alexis C Wood, Lisa R Yanek, Wei Zhao, Yinan Zheng, Josée Dupuis, Ching-Ti Liu, Robert Sladek, Jennifer Wessel, James B Meigs, Alisa K Manning, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium
Faculty, Staff and Students Publications
Large-scale multiancestry genome-wide association studies have identified hundreds of loci associated with type 2 diabetes (T2D) and glycemic traits, yet imputed genotyping arrays limit the detection of low-frequency and rare variants. Whole-genome sequencing (WGS) offers a more complete view of genetic variation, especially across diverse populations. We analyzed high-coverage (38×) WGS data from 21,913 T2D case subjects, 61,036 control subjects, and up to 50,011 individuals with no diabetes with fasting glucose, fasting insulin, and HbA1c from the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine Program. We performed single-variant association testing, conditional analysis, fine-mapping, and Bayesian colocalization to …
De Novo Complex Genomic Rearrangement Spanning 2q31.1 In A Proband With Congenital Malformations: Genotype-Phenotype Correlation And Development Of A Cgr Detection Pipeline, Katherine Helle, Jesse D Bengtsson, Mira Gandhi, Christopher M Grochowski, Ming Yin Lun, Neha Sudhir, Shalini N Jhangiani, Fritz J Sedlazeck, Seema R Lalani, Neil A Hanchard, Claudia M B Carvalho
De Novo Complex Genomic Rearrangement Spanning 2q31.1 In A Proband With Congenital Malformations: Genotype-Phenotype Correlation And Development Of A Cgr Detection Pipeline, Katherine Helle, Jesse D Bengtsson, Mira Gandhi, Christopher M Grochowski, Ming Yin Lun, Neha Sudhir, Shalini N Jhangiani, Fritz J Sedlazeck, Seema R Lalani, Neil A Hanchard, Claudia M B Carvalho
Faculty, Staff and Students Publications
The 2q31 region is commonly associated with pathogenic alleles of the HOXD cluster leading to various clinical phenotypes related to skeletal development. We present a proband with tetralogy of Fallot and multiple congenital anomalies. Genomic variant screening including an in-house CGR detection pipeline pairing genome sequencing (GS) structural variant calls with read-depth data revealed a de novo complex genomic rearrangement (CGR) spanning 2.7 Mb across 2q31 characterized by a series of duplications and triplications including the HOXD gene cluster. The genomic structure was assembled by applying combined methodologies including short-read and long-read GS, and optical genome mapping (OGM). This in-house …
Quantitative Imaging Of Pyruvate Metabolism In A Patient With Anaplastic Thyroid Cancer, James A Bankson, Joshua S Niedzielski, Collin J Harlan, Yunyun Chen, Christopher M Walker, Philip L Lorenzi, Lin Tan, Vikas Kundra, Matthew E Merritt, Mukundan Ragavan, Dawid Schellingerhout, Renjie He, Yao Ding, Sahana Datar, Qing Wang, Christine B Peterson, Clifton D Fuller, Vlad C Sandulache, Stephen Y Lai
Quantitative Imaging Of Pyruvate Metabolism In A Patient With Anaplastic Thyroid Cancer, James A Bankson, Joshua S Niedzielski, Collin J Harlan, Yunyun Chen, Christopher M Walker, Philip L Lorenzi, Lin Tan, Vikas Kundra, Matthew E Merritt, Mukundan Ragavan, Dawid Schellingerhout, Renjie He, Yao Ding, Sahana Datar, Qing Wang, Christine B Peterson, Clifton D Fuller, Vlad C Sandulache, Stephen Y Lai
Faculty, Staff and Students Publications
Purpose: Magnetic resonance imaging using hyperpolarized (HP) [1-13C]-pyruvate enables assessment of pyruvate metabolism in vivo and offers new insight into metabolic changes in response to cancer therapy. Widely used semi-quantitative metrics of pyruvate metabolism can be affected by physiological factors that are extrinsic to intracellular metabolism. A validated pharmacokinetic (PK) model for analysis of intracellular pyruvate metabolism is needed to enhance the accuracy of quantitative metrics and clinical translation of metabolic MRI using HP pyruvate.
Methods: A PK model with two physical compartments and two chemical pools was developed to analyze the conversion of labeled pyruvate into lactate in vitro. …
Attraction Of Nocturnal Scarab Beetles By Unusual Floral Volatiles In A Banksia (Proteaceae) With Functionally Diverse Pollinators, S. K. Wawrzyczek, B. Bohman, S. L. Krauss, I. M. Butler, G. R. Flematti, K. Farnier, S. E. Hoebee, R. A. Davis, R. D. Phillips
Attraction Of Nocturnal Scarab Beetles By Unusual Floral Volatiles In A Banksia (Proteaceae) With Functionally Diverse Pollinators, S. K. Wawrzyczek, B. Bohman, S. L. Krauss, I. M. Butler, G. R. Flematti, K. Farnier, S. E. Hoebee, R. A. Davis, R. D. Phillips
Research outputs 2022 to 2026
Pollination by beetles has evolved multiple times in flowering plants but with relatively few plant species adapted specifically to pollination by scarab beetles (Coleoptera: Scarabaeidae). However, some plant species may produce floral scents and offer floral rewards that attract scarabs alongside other pollinator functional groups. In Banksia attenuata (Proteaceae), nocturnal observations led to the discovery of extensive floral visitation by beetles, alongside birds, mammals and diurnal insects. Given the distinctive melon-like floral scent of B. attenuata, we predicted long-distance attraction of beetles by chemical cues. We undertook floral visitor surveys aided by camera traps and video recordings, and quantified insect …
Clogging Behaviour And Management In Two Full-Scale Infiltration Schemes: A Treated Wastewater Basin And A Surface-Water Weir In Australia, John Awad, Declan Page, Joanne Vanderzalm, Geoffrey J. Puzon, Jason Wylie, Falko Mathes, Debbie Reed, Michael Bartkow, Mehdi Khiadani, Karen Barry, Peter Dillon
Clogging Behaviour And Management In Two Full-Scale Infiltration Schemes: A Treated Wastewater Basin And A Surface-Water Weir In Australia, John Awad, Declan Page, Joanne Vanderzalm, Geoffrey J. Puzon, Jason Wylie, Falko Mathes, Debbie Reed, Michael Bartkow, Mehdi Khiadani, Karen Barry, Peter Dillon
Research outputs 2022 to 2026
Managed Aquifer Recharge (MAR) schemes are increasingly used to enhance water security, yet infiltration schemes are susceptible to clogging which consequently reduces operational efficiency. This study examines two full-scale Australian case studies: Jurien Bay (JB, Western Australia) and Lockyer Valley (LV, Queensland), representing treated wastewater (TWW) and surface water recharge, respectively. Recharge water at JB exhibited high clogging potential in relation to literature values proposed to manage clogging: total suspended solids (TSS) ranged from 100 to 176 mg/L (target ≤2 mg/L), turbidity 70–100 NTU (target ≤3 NTU), and total nitrogen (TN) 5–16 mg/L (target ≤10 mg/L). LV showed lower clogging …
Musical Training Increases Anticipatory Responding And Predictive Control In Sequence Learning, Li Ann Leow, Jarrad Lum, Sara Johnson, Emily Corti, Welber Marinovic
Musical Training Increases Anticipatory Responding And Predictive Control In Sequence Learning, Li Ann Leow, Jarrad Lum, Sara Johnson, Emily Corti, Welber Marinovic
Research outputs 2022 to 2026
Musicians demonstrate advantages in acquiring motor sequences, showing faster learning and better explicit sequence knowledge than non-musicians. However, it is unclear whether this advantage extends beyond acquisition to the consolidation phase, which is when newly learned skills stabilize and become resistant to interference. Additionally, while interference from executing competing motor tasks is well-established, less is known about whether purely sensory information presented after learning can disrupt consolidation of a bimodal motor sequence. We investigated how post-acquisition sensory interference affects performance of a learned audio-visual sequence, and whether musical training moderates this vulnerability. Participants first learned an explicit sequence in a …
Source-Specific Nitrate And Nitrite Intake And Bladder Cancer: Findings From The Danish Diet, Cancer And Health Cohort, Dorit W. Erichsen, Cecilie Kyrø, Jörg Schullehner, Susanne Rosthøj, Catherine P. Bondonno, Liezhou Zhong, Ole Raaschou-Nielsen, Pratik Pokharel, Torben Sigsgaard, Peter Fjeldstad Hendriksen, Frederik Dalgaard, Christina Dahl, Jonathan M. Hodgson, Christina C. Dahm, Anja Olsen, Anne Tjønneland, Nicola P. Bondonno
Source-Specific Nitrate And Nitrite Intake And Bladder Cancer: Findings From The Danish Diet, Cancer And Health Cohort, Dorit W. Erichsen, Cecilie Kyrø, Jörg Schullehner, Susanne Rosthøj, Catherine P. Bondonno, Liezhou Zhong, Ole Raaschou-Nielsen, Pratik Pokharel, Torben Sigsgaard, Peter Fjeldstad Hendriksen, Frederik Dalgaard, Christina Dahl, Jonathan M. Hodgson, Christina C. Dahm, Anja Olsen, Anne Tjønneland, Nicola P. Bondonno
Research outputs 2022 to 2026
Introduction Nitrate and nitrite, present in ground and drinking water, as well as foods, may contribute to bladder cancer through the formation of carcinogenic N -nitrosamines. However, risk likely depends on both the source and endogenous nitrosating factors. Methods Among participants of the Danish Diet, Cancer, and Health Cohort (N = 54,610) with no history of cancer, source-specific nitrate and nitrite intakes (drinking water, plant sources, naturally occurring animal sources, and additive-permitted meat sources) were estimated from national water monitoring data and food frequency questionnaires using food databases. Bladder cancer cases were ascertained through the Danish Cancer Registry. Multivariable-adjusted Cox …
Why Technical Readiness Is Not Enough: Institutional Barriers To Full Harvest Strategy Adoption In The International Pacific Halibut Commission, Evelyn Roozee, Owen Temby, Gordon M. Hickey
Why Technical Readiness Is Not Enough: Institutional Barriers To Full Harvest Strategy Adoption In The International Pacific Halibut Commission, Evelyn Roozee, Owen Temby, Gordon M. Hickey
School of Earth, Environmental, & Marine Sciences Faculty Publications
Harvest strategies are increasingly promoted as a mechanism to reduce political discretion and align fisheries management with pre-agreed scientific objectives. While substantial progress has been made in tuna regional fisheries management organizations (RFMOs), non-tuna RFMOs have lagged behind. Existing research has focused primarily on technical modeling challenges, with comparatively limited attention to the governance dynamics shaping adoption. Using the International Pacific Halibut Commission (IPHC) as an instrumental case study, we examine the progress and delays in the development of a harvest strategy policy (HSP) through semi-structured interviews and participant observation. We find that the IPHC successfully addressed commonly cited barriers, …
Greenhouse Gas Flux Response In Biochar- And Compost-Amended Lawn Soils Under Simulated Water Saturation Conditions, Angel Salinas, Chu-Lin Cheng, Engil Pereira, Rafael M. Almeida, James Jihoon Kang
Greenhouse Gas Flux Response In Biochar- And Compost-Amended Lawn Soils Under Simulated Water Saturation Conditions, Angel Salinas, Chu-Lin Cheng, Engil Pereira, Rafael M. Almeida, James Jihoon Kang
School of Earth, Environmental, & Marine Sciences Faculty Publications
Understanding greenhouse gas emission dynamics in lawn soils is important for improving climate change mitigation strategies in urban and suburban landscapes. In this greenhouse mesocosm study, carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O) fluxes were measured from 12 turfgrass soil columns arranged in an unreplicated, completely randomized 4 × 3 factorial design. Four amendment treatments (biochar, compost, bio-com [1:1 volume ratio of biochar and compost], and unamended control) were combined with three water-table conditions (full saturation, half saturation, and unsaturated), with a single column representing each treatment combination. Columns were irrigated at 1 cm day−1 for 24 days, …
Bridging Animal Production And Human Nutrition: How Production Ecology Shapes The Nutritional Quality Of Terrestrial Animal Foods And Human Omega-3 Status, Joseph Vinod Varre
Bridging Animal Production And Human Nutrition: How Production Ecology Shapes The Nutritional Quality Of Terrestrial Animal Foods And Human Omega-3 Status, Joseph Vinod Varre
All Graduate Theses and Dissertations, Fall 2023 to Present
The question at the center of this dissertation is simple: does the way food is produced change the quality of the food itself in ways that matter for human health? Across a series of studies on bison meat, eggs, and human dietary intervention, the answer was yes. This work began with a broad look at the modern food system and the nutritional consequences of industrialized diets. In particular, it focused on the growing imbalance between omega-6 and omega-3 fatty acids in the Western diet. This balance matters because omega-3 fats support heart, brain, and immune health, and diets high in …
Divergent Belowground Strategies Of Savanna Grasses Under Varying Fire Regimes, Abigail C. Schmidt
Divergent Belowground Strategies Of Savanna Grasses Under Varying Fire Regimes, Abigail C. Schmidt
All Graduate Theses and Dissertations, Fall 2023 to Present
Savannas are unique ecosystems, where trees and grasses live together across the landscape, not quite forming full forests or open grasslands. The ability for trees and grass to coexist is largely the result of widespread disturbances, such as fire. Fire in savannas is largely thought of in how it maintains plants above ground, however, fire also plays a key role in ecosystem and plant processes belowground. First, fire can change how soil nutrients, namely phosphorus, are cycled. Phosphorus is a key nutrient that plants need to function, and plants acquire phosphorus through their roots. Frequent fire can enhance phosphorus availability, …