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2026

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Osteoblastogenesis Stimulation By Human Umbilical Cord Stem Cell Secretome During Maxillary Expansion, Alexander Patera Nugraha Aug 2026

Osteoblastogenesis Stimulation By Human Umbilical Cord Stem Cell Secretome During Maxillary Expansion, Alexander Patera Nugraha

Articles in Press

No abstract provided.


Avian Mesenchymal Stem Cell-Derived Extracellular Vesicle Alleviates The Porphyromonas Gingivalis Lipopolysaccharide Induced Gingival Fibroblast Senescence, Cheng-Yang Chiang Aug 2026

Avian Mesenchymal Stem Cell-Derived Extracellular Vesicle Alleviates The Porphyromonas Gingivalis Lipopolysaccharide Induced Gingival Fibroblast Senescence, Cheng-Yang Chiang

Articles in Press

No abstract provided.


Developing An Automated Cytology-Based Dna Ploidy Test For Detecting Oral Squamous Cell Carcinoma In Taiwan: A Feasibility Study, Catherine F. Poh Aug 2026

Developing An Automated Cytology-Based Dna Ploidy Test For Detecting Oral Squamous Cell Carcinoma In Taiwan: A Feasibility Study, Catherine F. Poh

Articles in Press

No abstract provided.


Media Emotion Regulation And Executive Function In Childhood: Associations With Respiratory Sinus Arrhythmia, Lara M. Almeida Aug 2026

Media Emotion Regulation And Executive Function In Childhood: Associations With Respiratory Sinus Arrhythmia, Lara M. Almeida

Theses and Dissertations

Media emotion regulation (MER), or the use of media to help children manage emotions, may influence children's development by shaping opportunities for practicing self-regulatory skills. Guided by the Dynamic, Relational, Ecological Approach to Media Effects Research (DREAMER) model, this study examined longitudinal associations between MER and executive functioning (EF) in early childhood and explored whether respiratory sinus arrhythmia (RSA), a physiological index of regulation, predicted developmental changes. Participants included 175 parent-child dyads assessed across two annual waves when children were approximately 4 and 5 years old. Structural equation modeling was used to test bidirectional associations between MER and EF while …


Emotion-Attention Relationships In Anxiety: A Multimodal Psychophysiological Network Analysis, Kyle O'Brien Aug 2026

Emotion-Attention Relationships In Anxiety: A Multimodal Psychophysiological Network Analysis, Kyle O'Brien

Clinical Psychology Dissertations

Anxiety has long been associated with changes in attention processing, emotional salience detection, and emotional affect. Traditional methods of measuring anxiety frequently utilize self-report symptom measures, behavioral performance measures, and psychophysiological indicators. The current study integrates behavioral accuracy, self-report measures of psychological distress and well-being, and event-related potential markers of attention processing into an exploratory multimodal psychological network analyses to identify meaningful patterns across these indicators. The final sample of nonpatients included 36 anxious (low depression) and 24 control (low anxiety and depression) participants who completed an Emotion Attention Blink task while EEG data were collected to assess early, more …


Fraction-Seq: An Integrated Experimental And Computational Workflow For Determining The Localization And Abundance Of Small Non-Coding Rnas In Subcellular Compartments, Siddhartha Shah, Tess Cherlin, Yi Jing, Stepan Nersisyan, Benjamin E. Leiby, Isidore Rigoutsos Aug 2026

Fraction-Seq: An Integrated Experimental And Computational Workflow For Determining The Localization And Abundance Of Small Non-Coding Rnas In Subcellular Compartments, Siddhartha Shah, Tess Cherlin, Yi Jing, Stepan Nersisyan, Benjamin E. Leiby, Isidore Rigoutsos

Computational Medicine Center Faculty Papers

Small non-coding RNAs (sncRNAs) have garnered considerable attention in recent years, following accumulating evidence of their critical roles in many cellular processes. Among sncRNAs, microRNAs (miRNAs) and their isoforms (isomiRs), tRNA-derived fragments (tRFs), rRNA-derived fragments (rRFs), and Y RNA-derived fragments (yRFs) account for more than 95% of all sncRNAs found in cells. Despite their critical regulatory roles, most sncRNAs remain uncharacterized because their functionalization is a lengthy and challenging undertaking. Knowing an sncRNA's abundance helps prioritize among the various choices, while knowing where it localizes in the cell greatly limits the number and identity of its potential targets and helps …


Integrating Matrescence Into Birth Worker Practice: A Practice Improvement Project, Kelsey B. Green Aug 2026

Integrating Matrescence Into Birth Worker Practice: A Practice Improvement Project, Kelsey B. Green

Doctor of Nursing Practice (DNP) Projects

Background: Perinatal mood and anxiety disorders (PMADs) affect 20–25% of mothers worldwide and are a leading cause of maternal complications. Stigma, fragmented care, and limited provider training leave families vulnerable, while birth workers offer trusted, continuous support.

Problem: Birth workers' maternal mental health (MMH) training is minimal and often excludes matrescence, the developmental transition to motherhood, limiting their ability to distinguish normal adjustment from clinical PMADs and delaying intervention.

Methods: A single-group, pre-/post-test design evaluated a matrescence-informed workshop at Roots Community Health's 2nd Annual Symposium. Anonymous surveys measured knowledge, attitudes, and confidence, analyzed with Mann–Whitney U, Wilcoxon signed-rank tests, and …


Chronic Hiv And The Emerging Threat Of Neurodegeneration In The Aging Population, Delilah Frey, Isabella Lagunzad, Andrew Meltzer Aug 2026

Chronic Hiv And The Emerging Threat Of Neurodegeneration In The Aging Population, Delilah Frey, Isabella Lagunzad, Andrew Meltzer

URGENT Matters

No abstract provided.


Endoscopic Versus Catheter-Based Minimally Invasive Evacuation Of Spontaneous Supratentorial Intracerebral Hemorrhage: A Systematic Review And Meta-Analysis, Shaan Patel, Shiva A Nischal, Kush M Kale, Angelette Mendonca, Keenan Piper, Pious D. Patel, Michael R. Gooch, Stavropoula Tjoumakaris, Pascal M. Jabbour Aug 2026

Endoscopic Versus Catheter-Based Minimally Invasive Evacuation Of Spontaneous Supratentorial Intracerebral Hemorrhage: A Systematic Review And Meta-Analysis, Shaan Patel, Shiva A Nischal, Kush M Kale, Angelette Mendonca, Keenan Piper, Pious D. Patel, Michael R. Gooch, Stavropoula Tjoumakaris, Pascal M. Jabbour

Department of Neurosurgery Faculty Papers

Minimally invasive surgery (MIS) for spontaneous supratentorial intracerebral hemorrhage (sICH) includes endoscopic evacuation and catheter-based evacuation (aspiration or drainage ± thrombolysis), but comparative performance remains uncertain. We performed a systematic review and meta-analysis comparing MIS approaches. PubMed, Embase, and CENTRAL were searched (December 2025) for studies in adults undergoing endoscopic or catheter-based MIS for supratentorial sICH. Random-effects meta-analysis was conducted. Prespecified subgroup analyses stratified catheter-based techniques by thrombolysis use. Risk of bias and certainty of evidence was assessed. Twenty-nine studies (8221 patients; 5041 endoscopic; 3180 catheter-based) were included. Endoscopic evacuation was associated with lower mortality (RR 0.64; 95% CI: 0.47–0.87; …


Dry After-Ripening Increases Germination Of Critically Imperilled Physaria Thamnophila (Zapata Bladderpod), Christopher A. Gabler, Jerald T. Garrett Aug 2026

Dry After-Ripening Increases Germination Of Critically Imperilled Physaria Thamnophila (Zapata Bladderpod), Christopher A. Gabler, Jerald T. Garrett

School of Earth, Environmental, & Marine Sciences Faculty Publications

Effective endangered plant conservation and recovery require empirical knowledge of seed dormancy release and responses to post-collection handling, yet such information is lacking for many rare taxa. Physaria thamnophila (Zapata bladderpod; Brassicaceae), a critically imperilled (G1) species endemic to southern Texas, USA, is poorly studied, and basic questions regarding seed storage and germination remain unresolved. We evaluated the effects of short-term cool-storage duration (14–180 d), storage temperature (refrigeration vs. freezing), dry after-ripening and maternal plant identity on germination probability and timing in P. thamnophila. Dry after-ripening and increased cool-storage duration consistently increased germination and shortened germination time, whereas storage temperature …


Rethinking Teacher Education Programs: (Mis)Understanding Of Culturally Responsive Teaching Among Teacher Candidates, Shirley M. Sommers Aug 2026

Rethinking Teacher Education Programs: (Mis)Understanding Of Culturally Responsive Teaching Among Teacher Candidates, Shirley M. Sommers

Northwest Journal of Teacher Education

This article draws from a study conducted on pre-service teachers enrolled in a teacher education program. The study examines students’ understanding and misunderstanding of what constitutes culturally responsive teaching. This is a mixed methods study. A Likert-type survey and qualitative questionnaires were used to collect data. Descriptive statistics were used to analyze survey data, and a thematic coding method was used for analysis of qualitative data. The results of the study show that pre-service teachers are aware and knowledgeable of the term culturally responsive teaching as the term is widely used in the teacher education program in which they were …


Larotrectinib In Trk Fusion Differentiated Thyroid Carcinoma: Updated Trial Data, Steven Waguespack, Marcia Brose, Jessica J Lin, Ray Mcdermott, Mohammed Almubarak, Jessica Bauman, Michela Casanova, Shivaani Kummar, Se-Hoon Lee, Damian Rieke, Do-Youn Oh, Changsong Qi, Natascha Neu, Domnita-Ileana Burcoveanu, Chiara Mussi, Alexander Drilon, David Hong, Maria Cabanillas Aug 2026

Larotrectinib In Trk Fusion Differentiated Thyroid Carcinoma: Updated Trial Data, Steven Waguespack, Marcia Brose, Jessica J Lin, Ray Mcdermott, Mohammed Almubarak, Jessica Bauman, Michela Casanova, Shivaani Kummar, Se-Hoon Lee, Damian Rieke, Do-Youn Oh, Changsong Qi, Natascha Neu, Domnita-Ileana Burcoveanu, Chiara Mussi, Alexander Drilon, David Hong, Maria Cabanillas

Department of Medical Oncology Faculty Papers

Larotrectinib is a first-in-class, highly selective, central nervous system-active tropomyosin receptor kinase (TRK) inhibitor approved for tumour-agnostic use in TRK fusion cancer. It has previously demonstrated rapid and durable disease control and favourable safety in patients with advanced TRK fusion thyroid carcinoma (TC). After an additional 4 years of follow-up with the inclusion of two additional patients, and utilising an independent review committee (IRC) to assess overall response rate (ORR), we report updated pooled analyses from three phase 1-2 larotrectinib clinical trials, focusing only on patients with TRK fusion differentiated TC (DTC). The primary endpoint was the IRC-determined ORR per …


Enhancing Wildfire Resilience In The Rail Industry: Developing A Community Resilience Extreme Events Portal (Creep), Karl Kim, Eric Yamashita, Daniele Spirandeli, David Rother, Chris Chiesa, Greg Hampe, Michele Toner Aug 2026

Enhancing Wildfire Resilience In The Rail Industry: Developing A Community Resilience Extreme Events Portal (Creep), Karl Kim, Eric Yamashita, Daniele Spirandeli, David Rother, Chris Chiesa, Greg Hampe, Michele Toner

Mineta Transportation Institute

The Community Resilience Extreme Events Portal (CREEP) provides a centralized platform for accessing wildfire danger indices, critical asset locations, and vulnerability scores for rail segments. The project team developed a data-driven, indicator-based vulnerability assessment framework that defines vulnerability as a function of exposure, sensitivity, and adaptive capacity. To build this framework, the team selected publicly available datasets, prioritizing national datasets whenever possible to ensure transparency, reproducibility, and scalability. The portal allows users to analyze and visualize vulnerability across 1-kilometer segments of Class I freight and passenger rail lines in California, supporting planning and mitigation prioritization to help reduce rail-related fatalities, …


Self-Maintenance And The Evidence For Artificial Sentience, Mads J. Hansen, Christoffer Lundbak Olesen Aug 2026

Self-Maintenance And The Evidence For Artificial Sentience, Mads J. Hansen, Christoffer Lundbak Olesen

Animal Sentience

Birch aims to remain neutral about whether life is necessary for sentience. We argue that life can be given a role while maintaining neutrality. Markers of sentience have been identified in living systems, where some contribute to the system's self-maintenance. When such a marker is reproduced in an artificial system that is not self-maintaining it is not clear that it is as reliable as in living systems.


The Screening Tool Of Behavioral Self-Regulation “Head-Toes-Knees-Shoulders” Task: A Preliminary Adaptation To Greek Older Adults, Eleni Rachanioti, Dimitra Magkavila, Olga Fragkomichelaki, Magda Dinou, Effie Katsadima, Theodora Foti, Anastasia Tzalla, Anna Dougali, Christina Bourmpou, Maria Staikopoulou, Aphrodite Papantoniou, Fotini Varlami, Irene Dinaki, Maria Tsiountala, Konstantinos Staikopoulos, Tryfon Mavropalias, Efthymia Efthymiou, Demetra Tomprou, Maria Georgiadi, Dimitra Katsarou, Georgios Kougioumtzis, Ioanna Giannoula Katsouri, Harilaos Zaragas, Despina Moraitou, Maria Sofologi, Georgia Papantoniou Aug 2026

The Screening Tool Of Behavioral Self-Regulation “Head-Toes-Knees-Shoulders” Task: A Preliminary Adaptation To Greek Older Adults, Eleni Rachanioti, Dimitra Magkavila, Olga Fragkomichelaki, Magda Dinou, Effie Katsadima, Theodora Foti, Anastasia Tzalla, Anna Dougali, Christina Bourmpou, Maria Staikopoulou, Aphrodite Papantoniou, Fotini Varlami, Irene Dinaki, Maria Tsiountala, Konstantinos Staikopoulos, Tryfon Mavropalias, Efthymia Efthymiou, Demetra Tomprou, Maria Georgiadi, Dimitra Katsarou, Georgios Kougioumtzis, Ioanna Giannoula Katsouri, Harilaos Zaragas, Despina Moraitou, Maria Sofologi, Georgia Papantoniou

All Works

The aim of the present study was to examine the psychometric properties of the Head-Toes-Knees-Shoulders (HTKS) behavioral self-regulation (executive function) measure in a sample of Greek older population. Specifically, 88 cognitively healthy Greek older adults over the age of 65 participated in the study. The Greek version of HTKS was administered along with the Greek versions of the Mini-Mental State Examination (MMSE), the Raven's Educational CPM, the Number Series (NS) test, the Positive and Negative Affect Scale (PANAS), the Barratt Impulsiveness Scale (BIS-11) and the Impulsive Behavior Scale (UPPS-P). Exploratory factor analysis supported the unidimensional structure of the HTKS. The …


Evaluating Gender Equity In The Berenstain Bears Picture Books, Christy Tisnawijaya, Geni Kurniati Aug 2026

Evaluating Gender Equity In The Berenstain Bears Picture Books, Christy Tisnawijaya, Geni Kurniati

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

Picture books serve as a foundational medium in early childhood education, utilizing interrelated visual and verbal elements to foster linguistic, cognitive, and social development. Despite their pedagogical utility, certain literary works inadvertently perpetuate traditional gender roles, constraining children's conceptualizations of identity. This study evaluates gender representation within eleven selected titles of The Berenstain Bears series. Employing a qualitative multimodal content analysis, the study integrates Butler's gender performativity framework (1990), Callow's multimodal narrative approach (2020), and Adam and Harper's evaluative criteria (2021) to examine how domestic, social, and recreational roles are constructed. This study offers novelty by establishing a dual-lens multimodal …


Physical Activity, Trauma, And Posttraumatic Stress: The Indirect Role Of Exercise Addiction, Anastasiia Rozumna Aug 2026

Physical Activity, Trauma, And Posttraumatic Stress: The Indirect Role Of Exercise Addiction, Anastasiia Rozumna

Theses and Dissertations

Exercise is often conceptualized as a protective factor for mental health, including for individuals exposed to trauma. However, less is known about whether exercise may relate to posttraumatic stress symptoms differently when it is accompanied by compulsive or addictive features. The present study examined whether volume and intensity of physical activity were associated with posttraumatic stress symptom severity indirectly through exercise addiction symptoms. This secondary cross-sectional analysis included 557 adults living in the United States who reported regular participation in sport or physical activity. Participants completed self-report measures of physical activity behavior, exercise addiction symptoms, trauma exposure, and posttraumatic stress …


The Faunal Remains From The Roman–Early Byzantine Residential Quarter At Oboda (‘Avedat), Nimrod Marom Aug 2026

The Faunal Remains From The Roman–Early Byzantine Residential Quarter At Oboda (‘Avedat), Nimrod Marom

'Atiqot

Excavations in the town of Oboda in the Negev Highlands yielded faunal remains from Roman and Early Byzantine (late third–early fifth century CE) contexts. It was found that the site’s economy in both periods relied mainly on caprine flocks dominated by sheep.


The Importance Of An ‘Unimportant’ Toy: Children In The Ancient Domestic Sphere, Rona S. Avissar Lewis Aug 2026

The Importance Of An ‘Unimportant’ Toy: Children In The Ancient Domestic Sphere, Rona S. Avissar Lewis

'Atiqot

This paper examines an often-overlooked sector of households: children. The paper first presents the importance of children within the framework of the household and society, pointing out significant references from textual sources and imagery, such as orthostats. Then, a set of artifacts identified in the archaeological record is presented, which may be defined as spinning toys, comprising two components: a string and a perforated object. The conclusions discuss the way these toys reflect on the importance of children in society.


The Palestinian Arendtian Condition: Worldlessness In Kanafani’S Men In The Sun, Kareem Alsawalha Aug 2026

The Palestinian Arendtian Condition: Worldlessness In Kanafani’S Men In The Sun, Kareem Alsawalha

Discussions

No abstract provided.


The Palestinian Arendtian Condition: Worldlessness In Kanafani’S Men In The Sun Aug 2026

The Palestinian Arendtian Condition: Worldlessness In Kanafani’S Men In The Sun

Discussions

No abstract provided.


Malt-Nsom Ground Truth: Integrated Electromagnetic, Thermodynamic, And Acoustic Tensor Dataset For Biophysical Modeling, Daniel Schramm Aug 2026

Malt-Nsom Ground Truth: Integrated Electromagnetic, Thermodynamic, And Acoustic Tensor Dataset For Biophysical Modeling, Daniel Schramm

Defensive Publications Series

Title: MALT-NSOM: A Multi-Physics 3D Tensor Dataset for AI-Driven Oncological Biosensing and Targeted Therapeutics

Abstract:

This dataset provides a high-fidelity, multi-physics ground-truth benchmark for the MALT-NSOM (Metal-Assisted Lossless-Dielectric Nanophotonic Sub-diffraction Optical Microscopy) platform. Unlike noisy clinical datasets, this archive contains 3D tensor fields derived from first-principles Maxwell, Poisson, and Acoustic wave equations. It is designed for researchers developing machine learning models for predictive biomarker detection, sub-cellular diagnostic imaging, and non-invasive therapeutic targeting.

Data Generation & Methodology:

The dataset was constructed using three primary high-performance physics engines:

  1. Optics (MEEP/FDTD): 3D Maxwell tensor simulations of a bi-spherical Hafnium Oxide (HfO2) dimer cavity …


Technical Disclosure Specification: Wearable Biomimetic Harmonic Alignment Liner And Micro-Distributed Gan Power Stage Matrix For Biological Homeostasis, Christopher L. Eckes Aug 2026

Technical Disclosure Specification: Wearable Biomimetic Harmonic Alignment Liner And Micro-Distributed Gan Power Stage Matrix For Biological Homeostasis, Christopher L. Eckes

Defensive Publications Series

This specification formalizes the mechanical, electrical, and topological architecture for a wearable, direct-dermal biomimetic alignment garment designed to mitigate the systemic biological degradation pathways caused by prolonged microgravity exposure. Traditional aerospace paradigms treat gravity loss as an external mechanical force deficit, attempting to resolve bone-density wastage and fluidic intracranial crowding via clumsy macro-scale kinetic countermeasures (e.g., spinning centrifuges) or localized chemical vectors.

Under the Dimensionally Extended Holographic Projection (DEHP) cosmology, biology is re-modeled as a scale-invariant series of localized wave packets vibrating against a 2D viscoelastic fluid membrane resting at absolute equilibrium (\(z=0\)). This paper introduces an integrated, lightweight backpack …


Technical Disclosure Specification: Spherical Harmonic Field Confinement Generator And Molecular Conduction Wave Filters For Visorless Atmospheric Envelopes, Christopher L. Eckes Aug 2026

Technical Disclosure Specification: Spherical Harmonic Field Confinement Generator And Molecular Conduction Wave Filters For Visorless Atmospheric Envelopes, Christopher L. Eckes

Defensive Publications Series

This specification formalizes the physical architecture and low-level firmware constraints for a body-worn, spine-mounted Spherical Harmonic Field Confinement Generator capable of establishing a localized, un-tethered atmospheric breathing envelope and active radiation shield directly around an individual operator in a hard vacuum. Traditional extravehicular activity (EVA) systems rely heavily on high-friction mechanical containment units (e.g., pressurized polycarbonate visors and multi-layered fabric suits) that restrict joint mobility, maximize structural failure vectors, and demand high-mass portable life support back-assemblies.

Under the Dimensionally Extended Holographic Projection (DEHP) cosmology, macroscopic matter is treated as a scale-invariant series of localized wave-knots collapsed from an underlying two-dimensional …


#Narctalk: Analysis Of Perceptions Of Personality Disorders In Tiktok Content, Amanda C. Dediego, Auna Nelson, Feven Seifu, Amanda D. Tracy, Madeline Grubb, R.J. Schoen Aug 2026

#Narctalk: Analysis Of Perceptions Of Personality Disorders In Tiktok Content, Amanda C. Dediego, Auna Nelson, Feven Seifu, Amanda D. Tracy, Madeline Grubb, R.J. Schoen

Journal of Technology in Counselor Education and Supervision

No abstract provided.


Strategies For Integrating Death Education Into Asynchronous Online Counselor Training, Kara E. Wolff Aug 2026

Strategies For Integrating Death Education Into Asynchronous Online Counselor Training, Kara E. Wolff

Journal of Technology in Counselor Education and Supervision

Online counselor education has grown exponentially, with a greater number of courses being offered in an asynchronous format. This presents challenges and opportunities for counseling training in death education, a subset of grief counseling. Death anxiety and death avoidance can result in counselors-in-training's disengagement with strictly didactic materials in this area. Instead, death education must offer opportunities for experiential processing and personal reflection to be effective. Specific teaching strategies that foster the development of death acceptance and death competence within asynchronous online counselor education courses are offered.


Exploring Chatgpt As A Simulated Client: A Feasibility Study In Undergraduate Counselor Training, Kayla E. Hayes, Rebecca L. Wilson, Joshua Wilson Aug 2026

Exploring Chatgpt As A Simulated Client: A Feasibility Study In Undergraduate Counselor Training, Kayla E. Hayes, Rebecca L. Wilson, Joshua Wilson

Journal of Technology in Counselor Education and Supervision

Generative artificial intelligence (AI) offers new possibilities for simulation-based counselor training by enabling scalable, text-based interactions that mimic human dialogue. This exploratory feasibility study examined whether ChatGPT can serve as a simulated counseling client and feedback provider for undergraduate students learning counseling skills. Five upperclassmen completed a 45–60-minute text-based session with ChatGPT portraying “Sarah,” a college student experiencing depression and loneliness, followed by AI feedback and a semi-structured interview. Trained raters judged ChatGPT’s client portrayal and feedback as generally accurate, particularly for tone, empathy, and identification of students’ strengths. Accuracy was lower for rapport, summarizing, and pacing characteristic of an …


Chronotivity: Concurrent And Prospective Influences On Creative Performance Among College Students, Hreem Mahadeshwar Aug 2026

Chronotivity: Concurrent And Prospective Influences On Creative Performance Among College Students, Hreem Mahadeshwar

Theses

Creativity is increasingly understood as a dynamic process influenced by biological, psychological, and contextual factors. Previous research has linked chronotype, sleep quality, affect, curiosity, and creative self-efficacy to creative performance; however, relatively little is known about how these factors jointly relate to creativity among college students or whether they predict creative performance over time. The present study examined concurrent and prospective relationships in undergraduate students at RIT (T1: n = 210; T2: n = 38), between these variables and creative performance using a two-timepoint design. Creative performance was assessed using the Alternative Uses Task and scored for creative quality and …


Archaeal Signal Peptide Prediction Through Integration Of Proteomics And Machine Learning, Anjali Kaur Aug 2026

Archaeal Signal Peptide Prediction Through Integration Of Proteomics And Machine Learning, Anjali Kaur

Theses

Signal peptides are short N-terminal amino acid sequences that direct proteins through cellular secretion pathways and play an essential role in protein localization and function. Computational tools such as SignalP are widely used to predict signal peptides. However, prediction accuracy for archaeal proteins remains lower than for bacterial and eukaryotic proteins, likely because relatively few archaeal proteins were available for model training. The goal of this study was to determine whether expanding the archaeal training data used by SignalP 6.0 could improve archaeal signal peptide prediction. Archaeal proteomics datasets from five archaeal species were analyzed to identify proteins with experimentally …


Dynamics Of Microscale Droplets In Respiratory Airways, Md Shamser Ali Javed Aug 2026

Dynamics Of Microscale Droplets In Respiratory Airways, Md Shamser Ali Javed

Mathematics Theses and Dissertations

We investigate trajectories of microscale evaporating droplets in a stagnation point flow near a wall of a respiratory airway. The configuration is motivated by the problem of advection and deposition of microscale droplets of respiratory fluids in human airways during transmission of infectious diseases such as tuberculosis and COVID-19. Laminar boundary layer equations are solved to describe the air flow while the equations of motion of the droplet include contributions from gravity, aerodynamic drag, and Saffman force. Evaporation is accounted for at both the droplet surface and the wall of the respiratory airway and is shown to delay droplet deposition …