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Articles 13801 - 13830 of 18734
Full-Text Articles in Entire DC Network
High Stakes Literacy Testing: Indiana’S Iread-3, Christy Wessel Powell, Karyn Tomkinson, Whitney Rippy
High Stakes Literacy Testing: Indiana’S Iread-3, Christy Wessel Powell, Karyn Tomkinson, Whitney Rippy
Science of Reading
Indiana is one of a few states to enact a high stakes literacy test in third grade, the IREAD-3 test. High stakes testing is often a useful way to ensure a particular level of academic proficiency is met to allow students to succeed in a new setting, like college, or leave high school with desired skills. However, the requirement to automatically retain third graders who do not pass the IREAD-3 test without additional information or considerations, is not supported by research (AERA, 2000). These data highlight the critical need for educators and administrators to understand high-stakes standardized tests, as they …
Supporting Data – Urban Stream, Cardinal Court, Isu, Normal, November 9, 2023 To May 1, 2025, Eric Wade Peterson, Ava Miller
Supporting Data – Urban Stream, Cardinal Court, Isu, Normal, November 9, 2023 To May 1, 2025, Eric Wade Peterson, Ava Miller
Faculty Publications - Geography, Geology, and the Environment
Between November 9, 2023 to May 1, 2025, water samples were collected upstream and downstream along a segment of a stream adjacent to Cardinal Court on the Illinois State University campus. At each location, samples were collected at the surface. In-situ measurements of Dissolved Oxygen, Specific Conductance, and Temperature were recorded with a YSI 85. Anion samples were analyzed using a Ion Chromatograph for fluoride (F-), chloride (Cl-), nitrate as nitrogen (NO3-N), phosphate (PO43-), and sulfate (SO42-). The available dataset provides the recorded field parameters and the analyzed ion concentrations.
Anthelmintic Efficacy Of Rosemary Oil And Its Nanoemulsion Against The Monogenean Parasite, Zeuxapta Seriolae, In Yellowtail Kingfish (Seriola Lalandi), Md Reaz Chaklader, Lindsey Woolley, Hosna Gholipour-Kanani, Masashi Maita, Gavin Partridge
Anthelmintic Efficacy Of Rosemary Oil And Its Nanoemulsion Against The Monogenean Parasite, Zeuxapta Seriolae, In Yellowtail Kingfish (Seriola Lalandi), Md Reaz Chaklader, Lindsey Woolley, Hosna Gholipour-Kanani, Masashi Maita, Gavin Partridge
Fisheries Research Articles
This study evaluated the anthelmintic efficacy of rosemary oil delivered as a nanoemulsion compared with regular rosemary oil against the monogenean parasite Zeuxapta seriolae in yellowtail kingfish (YTK; Seriola lalandi). A 20-day feeding trial tested three dietary treatments: two levels of regular rosemary oil (providing 0.85 and 1.7 g cineole·kg−1 feed) and a rosemary-oil nanoemulsion (providing 0.85 g cineole·kg−1 feed), against a control diet without rosemary oil. Juvenile fish (293 ± 5 g) were pre-exposed to Z. seriolae oncomiracidia before the trial, resulting in an initial mean parasite abundance of 97 ± 4 per fish. At trial completion, plasma …
Medical Device Dangers: Choosing Ignorance In The Courts And At The Fda, George Horvath
Medical Device Dangers: Choosing Ignorance In The Courts And At The Fda, George Horvath
William & Mary Law Review
Medical devices save lives and improve well-being but have caused as many as 83,000 deaths and 1.7 million injuries in a recent decade. Decisions of critical importance—patients’ decisions whether to have a device implanted, doctors’ decisions about which device to use, insurers’ decisions whether to reimburse for those devices—depend on information about risk that is provided by manufacturers. But producing this information is costly. Injured patients, through private lawsuits under state products liability theories, can incentivize device manufacturers to incur these costs and to produce and disclose information about device risk. Unfortunately, courts are making it increasingly unlikely that this …
Skrmetti And The Problem Of Incidental Intent, Martin Katz
Skrmetti And The Problem Of Incidental Intent, Martin Katz
William & Mary Law Review
The modern Supreme Court has defined “discriminatory intent” as a strict-liability concept. It does not matter why the government sorts people by a protected characteristic, such as race or sex; it matters only that the government does sort people by such a characteristic. This principle is the key holding of affirmative-action cases, such as Students for Fair Admissions, Inc. v. President & Fellows of Harvard College. Yet, in the recent case United States v. Skrmetti, the Court seemed to focus not on the question of whether the government sorted people by sex (it did), but on the question …
Interannual Variation In Seed Traits Of Cedrela Species, Guadalupe Galíndez, Ana Álvarez, Diana Ceccato, Victoria Rivero, Gisela Malagrina, Tania Bertuzzi, Pablo Saravia, Stavros Nicolás Sola, Carol C. Baskin, Luis Fornes
Interannual Variation In Seed Traits Of Cedrela Species, Guadalupe Galíndez, Ana Álvarez, Diana Ceccato, Victoria Rivero, Gisela Malagrina, Tania Bertuzzi, Pablo Saravia, Stavros Nicolás Sola, Carol C. Baskin, Luis Fornes
Plant and Soil Sciences Faculty Publications
Climate change is altering temperature and precipitation regimes in Argentina, with potential consequences for regeneration and persistence of forest tree species, emphasizing the importance of ex situ seed conservation. We evaluated interannual variation in seed traits, desiccation tolerance, storage behavior, and longevity of Cedrela balansae C. DC. and C. fissilis Vell. (Meliaceae), two endangered native species of subtropical rainforests in Argentina. Both species produced desiccation-tolerant seeds, independently of collection year, seed traits, or climatic conditions. Depending on the species, seed traits and longevity varied across years and showed strong relationships with temperature and precipitation, particularly during seed development. Cedrela balansae …
Synthetic Microbial Communities Enhance Tobacco Quality By Driving Bacterial Community Succession And Modulating Metabolite Profiles, Kuifu Men, Huaqiang Xuan, Jingrui Chen, Hongliang Li, Xuwei Chen, Yingle Jiao, Xianchao Shang, Yi Xie, Li Zhang, Long Yang, Ling Yuan, Sitakanta Pattanaik, Xin Hou
Synthetic Microbial Communities Enhance Tobacco Quality By Driving Bacterial Community Succession And Modulating Metabolite Profiles, Kuifu Men, Huaqiang Xuan, Jingrui Chen, Hongliang Li, Xuwei Chen, Yingle Jiao, Xianchao Shang, Yi Xie, Li Zhang, Long Yang, Ling Yuan, Sitakanta Pattanaik, Xin Hou
Plant and Soil Sciences Faculty Publications
The fermentation of cigar tobacco leaves (CTLs) is a critical process driven by microbial activity, which directly influences the degradation of macromolecules and the development of distinctive aromas. However, mechanisms for the directional regulation of this process using defined microbial consortia remain underexplored. This study aimed to construct a synthetic microbial community (SynCom) to enhance the fermentation efficiency and quality of cigar tobacco leaves. Bacillus safensis and Bacillus velezensis with high extracellular cellulase, amylase and protease activities were screened out, and synthetic communities were constructed. This microbial community was applied to cigar tobacco leaves (cultivar QX204) during a 42-day fermentation. …
Association Of Clinical Severity In Autism Spectrum Disorder With Biomolecules Involved In Lipid Metabolism, Inflammation And Mirnas, Maria Gevezova, Michael Maes, Iliana Pacheva, Nikolay Mehterov, Zdravko Ivanov, Elena Timova, Stefka Spassieva, Erhard Bieberich, Maria Kazakova, Ivan Ivanov, Victoria Sarafian
Association Of Clinical Severity In Autism Spectrum Disorder With Biomolecules Involved In Lipid Metabolism, Inflammation And Mirnas, Maria Gevezova, Michael Maes, Iliana Pacheva, Nikolay Mehterov, Zdravko Ivanov, Elena Timova, Stefka Spassieva, Erhard Bieberich, Maria Kazakova, Ivan Ivanov, Victoria Sarafian
Markey Cancer Center Faculty Publications
Autism spectrum disorder (ASD) is a heterogeneous neurological condition with an unclear etiology and pathogenesis. In recent years, studies have identified changes in lipid metabolism, inflammation, mitochondrial dysfunction, and mitophagy in patients with ASD. However, the specific interactions between these molecular signatures and their clinical applications in ASD remain largely unexplored. The aim of our study is to search for correlations between changes in gene and miRNA expression and the clinical characteristics of ASD. The investigation included a cohort of children with idiopathic ASD and healthy controls (HC). Diagnosis was established based on ADOS assessment (autism diagnostic observation schedule). Gene …
Asthma Phenotypes And Control In 22q11.2 Deletion Syndrome: A Single-Center Retrospective Study, Cody Shopper, Katey Campbell, Nikita S. Raje
Asthma Phenotypes And Control In 22q11.2 Deletion Syndrome: A Single-Center Retrospective Study, Cody Shopper, Katey Campbell, Nikita S. Raje
Posters
Background: Patients with 22q11.2 deletion syndrome have increased rates of atopy and immune dysregulation and may experience a higher burden of asthma; however, real-world data describing asthma control, severity, and treatment patterns in this population are limited. We hypothesized that asthma control and severity patterns in patients with 22q11.2 deletion syndrome differ from those observed in the general asthma population. Objectives/Goal: To characterize asthma control, severity, and treatment patterns among patients with 22q11.2 deletion syndrome and to compare observed patterns with those typically reported in the general asthma population. Methods/Design: We conducted a retrospective observational cohort study of patients with …
Market Culture And Innovation Acceptance In Fire Safety Products: The Moderating Role Of Perceived Market Regulation, Xu Zhang
Dissertations and Theses Collection (Open Access)
Against the backdrop of continuously rising global fire safety standards and ongoing technological iteration in fire protection products, whether innovative fire protection products can be effectively accepted by the market has become a critical issue influencing the returns on firms’ innovation investments and the high-quality development of the industry. Existing studies have predominantly explored innovation diffusion mechanisms from the perspectives of technological attributes or organizational factors, while paying relatively limited attention to market culture as a contextual factor, as well as to the differentiated role that government regulation may play in this process. Based on this, this study takes institutional …
Border Perceptions: Security And Immigration In The South Texas Borderlands, Carla Angulo-Pasel, Mi-Son Kim, Adrien A. Halliez
Border Perceptions: Security And Immigration In The South Texas Borderlands, Carla Angulo-Pasel, Mi-Son Kim, Adrien A. Halliez
School of Political Science, Public Affairs, Legal and Security Studies Faculty Publications
With the Trump administration, we witnessed a hardening of border security policy and practices. Trump used his leadership and celebrity to explicitly attack and criminalize “undocumented” migrants with a discourse of threat, danger, invasion, crisis. Policywise, he took steps to further securitize the borderlands. In this paper, we examine how public opinion has differed with regards to the support or opposition to these hard security policies, especially in borderland areas when compared to the overall national population. The aim of this paper is to examine this difference by directing our attention to the Rio Grande Valley (RGV), a borderlands region …
Catatonia And Elevated Mortality: A Population-Wide Cohort Study With Healthy, Sibling, And Schizophrenia Spectrum Controls, Chih-Wei Hsu, Yang-Chieh Brian Chen, Marco Solmi, Chih-Sung Liang, Mu-Hong Chen, Yao-Hsu Yang, Liang-Jen Wang, Edward Chia-Cheng Lai
Catatonia And Elevated Mortality: A Population-Wide Cohort Study With Healthy, Sibling, And Schizophrenia Spectrum Controls, Chih-Wei Hsu, Yang-Chieh Brian Chen, Marco Solmi, Chih-Sung Liang, Mu-Hong Chen, Yao-Hsu Yang, Liang-Jen Wang, Edward Chia-Cheng Lai
Children’s Nutrition Research Center Staff Publications
Aim: To determine whether catatonia is associated with increased long-term all-cause and cause-specific mortality.
Methods: Using Taiwan's National Health Insurance Database (2000-2022), we assembled a population-based cohort of all adults (≥18 years) with catatonia and matched each to four controls without catatonia on sex and birthdate. Mortality was compared between (1) individuals with catatonia and their unaffected siblings and (2) individuals with schizophrenia spectrum disorders with catatonia and those with schizophrenia spectrum disorders without catatonia. The primary outcome was all-cause mortality; secondary outcomes were natural- and unnatural-cause deaths. Adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated with …
Phenofit: A Framework For Determining Computable Phenotyping Algorithm Fitness For Purpose And Reuse, Laura K Wiley, Luke V Rasmussen, Rebecca T Levinson, Jennnifer Malinowski, Sheila M Manemann, Melissa P Wilson, Martin Chapman, Jennifer A Pacheco, Theresa L Walunas, Justin B Starren, Suzette J Bielinski, Rachel L Richesson
Phenofit: A Framework For Determining Computable Phenotyping Algorithm Fitness For Purpose And Reuse, Laura K Wiley, Luke V Rasmussen, Rebecca T Levinson, Jennnifer Malinowski, Sheila M Manemann, Melissa P Wilson, Martin Chapman, Jennifer A Pacheco, Theresa L Walunas, Justin B Starren, Suzette J Bielinski, Rachel L Richesson
2020-Current year OA Pubs
BACKGROUND: Computational phenotyping from electronic health records (EHRs) is essential for clinical research, decision support, and quality/population health assessment, but the proliferation of algorithms for the same conditions makes it difficult to identify which algorithm is most appropriate for reuse.
OBJECTIVE: To develop a framework for assessing phenotyping algorithm fitness for purpose and reuse.
FITNESS FOR PURPOSE: Phenotyping algorithms are fit for purpose when they identify the intended population with performance characteristics appropriate for the intended application.
FITNESS FOR REUSE: Phenotyping algorithms are fit for reuse when the algorithm is implementable and generalizable-that is, it identifies the same intended population …
The Sport Publication Observational Research Tool (Sport): An Objective Tool To Score The Methodological Quality Of Observational Clinical Sports Medicine Research, Andrew W Kuhn, Paul M Inclan, Ameer A Haider, Michele N Christy, Robert Brophy, Matthew Smith, Matthew J Matava, Et Al.
The Sport Publication Observational Research Tool (Sport): An Objective Tool To Score The Methodological Quality Of Observational Clinical Sports Medicine Research, Andrew W Kuhn, Paul M Inclan, Ameer A Haider, Michele N Christy, Robert Brophy, Matthew Smith, Matthew J Matava, Et Al.
2020-Current year OA Pubs
BACKGROUND: A critical component of conducting systematic reviews or meta-analyses is assessing the methodological quality and bias of included studies. Several methodological quality assessment tools have been developed; however, these tools may not be relevant to observational sports medicine research, which carries numerous unique nuances and biases.
PURPOSE: To develop the Sport Publication Observational Research Tool (SPORT), which evaluates and scores the methodological quality of observational sports medicine research.
STUDY DESIGN: Consensus statement.
METHODS: SPORT was developed through a modified Delphi approach involving members from the Herodicus Society and The FORUM. All active members were invited to participate in the …
Blood Dna Methylation-Predicted Plasma Protein Levels And Colorectal Cancer Survival, Alicia R Richards, Maria F Gomez, Bianca I Dowling, Esther Jean-Baptiste, Biljana Gigic, Jane C Figueiredo, Christopher I Li, David Shibata, Adetunji T Toriola, Doratha A Byrd, Cornelia M Ulrich, Paul A Stewart, Erin M Siegel, Jacob K Kresovich
Blood Dna Methylation-Predicted Plasma Protein Levels And Colorectal Cancer Survival, Alicia R Richards, Maria F Gomez, Bianca I Dowling, Esther Jean-Baptiste, Biljana Gigic, Jane C Figueiredo, Christopher I Li, David Shibata, Adetunji T Toriola, Doratha A Byrd, Cornelia M Ulrich, Paul A Stewart, Erin M Siegel, Jacob K Kresovich
2020-Current year OA Pubs
BACKGROUND: Protein EpiScores are a novel class of DNA methylation (DNAm)-based metrics proposed to measure peripheral immune system characteristics. Although Protein EpiScores have been associated with chronic disease risk, their relationship with colorectal cancer (CRC) survival has not been investigated.
METHODS: We generated new genome-wide DNAm data on pre-treatment whole blood samples from a case-control sample of 136 newly diagnosed CRC patients nested in the ColoCare Study and calculated 107 Protein EpiScores using the developer's algorithm. Over a median follow-up of 7.3 years (range: 0.3-13.8 years), 35 (26%) patients experienced disease recurrence, and 47 (35%) died. Protein EpiScore associations with …
Multi-Modal Pediatric Critical Care Datamart For Extracorporeal Support Prediction And Decision Support, Miranda Edmunds, Aditi Gupta, Inez Oh, Levi Kaster, Jonathan Sagel, Andrew Michelson, Yuyao Zhuge, Philip Payne, Ahmed Said
Multi-Modal Pediatric Critical Care Datamart For Extracorporeal Support Prediction And Decision Support, Miranda Edmunds, Aditi Gupta, Inez Oh, Levi Kaster, Jonathan Sagel, Andrew Michelson, Yuyao Zhuge, Philip Payne, Ahmed Said
2020-Current year OA Pubs
OBJECTIVES: To develop a multimodal pediatric critical care datamart supporting predictive modeling and decision support tool development, integrating high-resolution physiologic and clinical data and future clinical deployment.
MATERIALS AND METHODS: We developed a continuously expanding datamart integrating electronic health record data, high-resolution telemetry, and extracorporeal membrane oxygenation (ECMO)-domain datasets. The platform links static and longitudinal time-series variables with expert-curated neurologic outcomes for both ECMO and non-ECMO patients, enabling trajectory-based analyses.
RESULTS: The datamart currently includes 25 762 pediatric patients, of whom 395 received ECMO support. The datamart captures granular longitudinal physiologic, laboratory, medication, and telemetry data suitable for dynamic predictive …
Cellscout: Visual Analytics For Mining Biomarkers In Cell State Discovery, Rui Sheng, Zelin Zang, Jiachen Wang, Yan Luo, Zixin Chen, Yan Zhou, Shaolun Ruan, Huamin Qu
Cellscout: Visual Analytics For Mining Biomarkers In Cell State Discovery, Rui Sheng, Zelin Zang, Jiachen Wang, Yan Luo, Zixin Chen, Yan Zhou, Shaolun Ruan, Huamin Qu
Research Collection School Of Computing and Information Systems
Cell state discovery is crucial for understanding biological systems and enhancing medical outcomes. A key aspect of this process is identifying distinct biomarkers that define specific cell states. However, difficulties arise from the co-discovery process of cell states and biomarkers: biologists often use dimensionality reduction to visualize cells in a two-dimensional space. Then they usually interpret visually clustered cells as distinct states, from which they seek to identify unique biomarkers. However, this assumption is often this assumption often fails to hold due to internal inconsistencies in a cluster, making the process trial-and-error and highly uncertain. Therefore, biologists urgently need effective …
February 2026 News Releases, University Of Montana--Missoula. Office Of University Relations
February 2026 News Releases, University Of Montana--Missoula. Office Of University Relations
University of Montana News Releases, 1928, 1956-present
No abstract provided.
Animal Taxa Threatened By Adverse Fire Regimes In Western Australia: A Synthesis And Outlook, Tim S. Doherty, Mark G. Allen, Karlene Bain, Stephen J. Beatty, Allan H. Burbidge, Renee A. Catullo, Sarah Comer, Ben Corey, Saul J. Cowen, Robert A. Davis, Martin A. Dziminski, J. Anthony Friend, Bruce Greatwich, Mark S. Harvey, Hannah Killian, Michael W. Klunzinger, Damian C. Lettoof, Nicola J. Mitchell, Melinda Moir, Harry A. Moore, David L. Morgan, Ian J. Radford, Michael G. Rix, Tom Vigilante, Adrian F. Wayne, Corey Whisson
Animal Taxa Threatened By Adverse Fire Regimes In Western Australia: A Synthesis And Outlook, Tim S. Doherty, Mark G. Allen, Karlene Bain, Stephen J. Beatty, Allan H. Burbidge, Renee A. Catullo, Sarah Comer, Ben Corey, Saul J. Cowen, Robert A. Davis, Martin A. Dziminski, J. Anthony Friend, Bruce Greatwich, Mark S. Harvey, Hannah Killian, Michael W. Klunzinger, Damian C. Lettoof, Nicola J. Mitchell, Melinda Moir, Harry A. Moore, David L. Morgan, Ian J. Radford, Michael G. Rix, Tom Vigilante, Adrian F. Wayne, Corey Whisson
Research outputs 2022 to 2026
Adverse fire regimes threaten biodiversity, potentially leading to population declines and increased extinction risk. Understanding how varying fire regimes affect threatened species is essential for effective ecosystem management, including in Western Australia where diverse ecosystems are exposed to wildfires, Indigenous burning, and prescribed fire. We compiled and synthesised data on the threat of adverse fire regimes to threatened animal taxa in Western Australia. Using a threat classification scheme, we ranked adverse fire regimes as having either no, low, medium, high, or unknown impact on each taxon. A total of 212 taxa were reviewed, 153 (72%) of which are considered fire-threatened: …
Evaluation Of Host-Immune Biomarker Signatures As Multiplex Qpcr Diagnostic Assays: A Pilot Study Toward Meeting Who Target Product Profiles For Tb Diagnosis In India, Harriet N. Garlant, Kalaiarasan Ellappan, Noyal Mariya Joseph, Carrie Turner, Vishnukanth Govindaraj, Saka Vinod Kumar, Sanjeev Kumar, Seshadri S. Vasan, Karen Elizabeth Kempsell
Evaluation Of Host-Immune Biomarker Signatures As Multiplex Qpcr Diagnostic Assays: A Pilot Study Toward Meeting Who Target Product Profiles For Tb Diagnosis In India, Harriet N. Garlant, Kalaiarasan Ellappan, Noyal Mariya Joseph, Carrie Turner, Vishnukanth Govindaraj, Saka Vinod Kumar, Sanjeev Kumar, Seshadri S. Vasan, Karen Elizabeth Kempsell
Research outputs 2022 to 2026
Background: Tuberculosis (TB) remains the leading cause of death from a single infectious agent. Current diagnostic tools are limited, especially in low-resource settings. The World Health Organization's (WHO) Target Product Profiles (TPPs) call for rapid, non-sputum-based diagnostics with high sensitivity and specificity. This study evaluates our previously published TB-associated host-immune biomarkers alongside small-size signatures from other studies, in our previously published non-human primate (NHP) TB infection study dataset (GSE76703) and two previously published human datasets (GSE144127, GSE42834), which include other disease group comparators, including sarcoidosis. These were also evaluated in a small-scale, exploratory qPCR pilot study to assess the feasibility …
Getting Edgy: Implications Of Fragmented Seagrass Meadows For Fish Assemblages, Simone Strydom, Kathy Murray, Molly Moustaka, Glenn Hyndes, Shaun Wilson
Getting Edgy: Implications Of Fragmented Seagrass Meadows For Fish Assemblages, Simone Strydom, Kathy Murray, Molly Moustaka, Glenn Hyndes, Shaun Wilson
Research outputs 2022 to 2026
Context: Seagrasses are key marine habitats that are increasingly degraded globally due to anthropogenic disturbances and climate change, compromising the ecosystem services they provide. While seagrass loss is often patchy, the ecological consequences of meadow fragmentation on marine fauna remains unclear. Objectives: This study (1) quantified decadal change in seagrass habitat and fragmentation of the globally important meadows of the Shark Bay World Heritage Area following the 2011 marine heatwave (MHW); and (2) assessed how meadow structure and fragmentation influence fish assemblages. Methods: We integrated in situ seagrass data with seascape metrics derived from habitat maps generated from satellite imagery …
Carbohydrate Restriction Drives Greater Perturbations In Circulating Metabolites Than Low Energy Availability In Elite Male Athletes, Kyle A. Dunlop, Nathan G. Lawler, Jamie Whitfield, Alannah K.A. Mckay, Nicolin Tee, Megan L. Ross, Stacey N. Reinke, John A. Hawley, David Broadhurst, Louise M. Burke
Carbohydrate Restriction Drives Greater Perturbations In Circulating Metabolites Than Low Energy Availability In Elite Male Athletes, Kyle A. Dunlop, Nathan G. Lawler, Jamie Whitfield, Alannah K.A. Mckay, Nicolin Tee, Megan L. Ross, Stacey N. Reinke, John A. Hawley, David Broadhurst, Louise M. Burke
Research outputs 2022 to 2026
Periods of low energy availability (LEA) are common in elite athletes and typically arise from reduced energy intake, often involving some degree of carbohydrate (CHO) restriction. Whether the metabolic profile created by energy restriction per se is distinct compared to that driven by CHO restriction is unknown. Using untargeted metabolomics, we examined metabolic perturbations linked to CHO restriction and energy restriction in plasma from elite male endurance athletes. In a semi-randomized controlled trial, athletes (n = 20) completed one of three 5-day dietary interventions: high energy-high CHO (HCHO); LEA (energy-restricted, CHO-reduced); or low-CHO, high-fat (LCHF; energy-matched, CHO-restricted). Plasma samples were …
Novel Small-Molecule Analogues Of Iu1 Ameliorate Amyloid-Β Mediated Toxicity In Alzheimer’S Disease Cell And Worm Models, Ajish Ariyath, Fraulein Denise Arigo, Izhar Wallach, W. M.A.D.Binosha Fernando, Ralph N. Martins, Prashant Bharadwaj
Novel Small-Molecule Analogues Of Iu1 Ameliorate Amyloid-Β Mediated Toxicity In Alzheimer’S Disease Cell And Worm Models, Ajish Ariyath, Fraulein Denise Arigo, Izhar Wallach, W. M.A.D.Binosha Fernando, Ralph N. Martins, Prashant Bharadwaj
Research outputs 2022 to 2026
Dysregulation of the deubiquitinating enzyme Ubiquitin-specific peptidase 14 (USP14) is implicated in several neurodegenerative diseases, and IU1, an allosteric inhibitor, has shown neuroprotective effects by reducing protein aggregate toxicity. This study aimed to develop new IU1 analogues and evaluate their ability to mitigate amyloid-β (Aβ) accumulation and toxicity in Alzheimer’s disease (AD) cell and Caenorhabditis elegans worm models. IU1 and 71 newly designed analogues identified using the AtomNet® virtual screening platform were assessed in an amyloid precursor protein-C terminal fragment/amyloid-β (APP-C99/Aβ)-producing AD cell model using a high-throughput toxicity assay. Lead compounds were further evaluated for their effects on neurodegeneration, …
Plasma Biomarker Progression Across The Alzheimer's Disease Amyloid Beta And Tau Positron Emission Tomography Trajectories, Rodrigo Cánovas, Christopher J. Fowler, Azadeh Feizpour, Vincent Dóre, Pierrick Bourgeat, Ziad S. Saad, Gallen Triana-Baltzer, Hartmuth C. Kolb, Manu Vandijck, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Jurgen Fripp, Simon Laws, Anthony W. Bannon, Kaj Blennow, Henrik Zetterberg, Stephanie Rainey-Smith, Sulantha Mathotaarachchi, Christopher C. Rowe, Colin L. Masters, James D. Doecke
Plasma Biomarker Progression Across The Alzheimer's Disease Amyloid Beta And Tau Positron Emission Tomography Trajectories, Rodrigo Cánovas, Christopher J. Fowler, Azadeh Feizpour, Vincent Dóre, Pierrick Bourgeat, Ziad S. Saad, Gallen Triana-Baltzer, Hartmuth C. Kolb, Manu Vandijck, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Jurgen Fripp, Simon Laws, Anthony W. Bannon, Kaj Blennow, Henrik Zetterberg, Stephanie Rainey-Smith, Sulantha Mathotaarachchi, Christopher C. Rowe, Colin L. Masters, James D. Doecke
Research outputs 2022 to 2026
Introduction: With increased uptake in disease-modifying treatments for amyloid beta (Aβ) removal, it is important to measure performance of highly sensitive plasma biomarkers to detect the presence of Aβ and tau in cognitively impaired populations. Methods: In this study, we investigated a large set of plasma biomarkers for their capability to predict Aβ and tau positron emission tomography (PET) and their association with increasing Aβ and tau burden. RESULTS: From the biomarkers assessed, tau phosphorylated at threonine 217 (pTau217) showed the largest increases across the full range of Aβ and tau levels. Furthermore, pTau217/Aβ42 had the smallest proportion of participants …
Regulation Of Autophagy-Mediated Pathways By Diet, Physical Activity, And Sleep In Alzheimer's Disease, Ajish Ariyath, Zoe Mputhia, Christopher Dougherty, Bushra Kaleelur Rahuman, W. M.A.D.Binosha Fernando, Belinda Brown, Samantha L. Gardener, Stephanie R. Rainey-Smith, Ralph Martins, Prashant Bharadwaj
Regulation Of Autophagy-Mediated Pathways By Diet, Physical Activity, And Sleep In Alzheimer's Disease, Ajish Ariyath, Zoe Mputhia, Christopher Dougherty, Bushra Kaleelur Rahuman, W. M.A.D.Binosha Fernando, Belinda Brown, Samantha L. Gardener, Stephanie R. Rainey-Smith, Ralph Martins, Prashant Bharadwaj
Research outputs 2022 to 2026
Alzheimer's disease (AD) is a progressive, age-related, neurodegenerative disorder marked by cognitive decline, memory loss, and accumulation of amyloid beta (Aβ) plaques and tau tangles. A key feature of AD is impaired protein homeostasis, often driven by autophagy dysfunction. Autophagy, a cellular degradation and recycling process, plays a vital role in maintaining neuronal health and is increasingly recognized as a therapeutic target in AD. Lifestyle factors such as diet, physical activity, and sleep can positively influence autophagy and support cognitive function. Intermittent fasting (IF) and calorie restriction (CR) activate autophagy and promote longevity; physical activity enhances cerebral blood flow and …
Taurine Supplementation And Human Heat Tolerance: Mechanisms, Evidence, And Integration With Heat Acclimation, Cooling, And Hydration, Siavash Naddafha, Jeffrey R. Stout, Cassandra Evans
Taurine Supplementation And Human Heat Tolerance: Mechanisms, Evidence, And Integration With Heat Acclimation, Cooling, And Hydration, Siavash Naddafha, Jeffrey R. Stout, Cassandra Evans
Research outputs 2022 to 2026
Heat exposure during strenuous exercise increases core temperature and cardiovascular strain, impairing performance and elevating the risk of heat illness. Standard countermeasures include heat acclimation, cooling, and hydration/electrolyte planning. Taurine is a sulfur-containing amino acid present in excitable tissues and widely used as an oral supplement; emerging human trials suggest it can augment thermoregulation, primarily by enhancing eccrine sweating and evaporative heat loss. This narrative review synthesizes mechanistic and applied evidence on taurine during exercise in hot environments and evaluates potential interactions with acclimation, cooling strategies (pre- and per-cooling), and hydration practices. Across a small number of randomized, mostly double-blind …
Demographic And Other Correlates Of Non-Prescription Drug Use Among College Students During The Covid-19 Pandemic, Subi Gandhi, Sidketa Fofana, Md Rafiul Islam, Tamer Oraby
Demographic And Other Correlates Of Non-Prescription Drug Use Among College Students During The Covid-19 Pandemic, Subi Gandhi, Sidketa Fofana, Md Rafiul Islam, Tamer Oraby
School of Mathematical & Statistical Sciences Faculty Publications
Background and objectives: Substance use among college students in the U.S. remains a pressing concern and may have intensified during the COVID-19 pandemic due to increased stress, uncertainty, and academic disruptions. This study investigates the relationship between non-prescription drug use and various demographic, mental health, and behavioral factors among college students during the pandemic's early stages.
Methods: Data were collected through online and in-person surveys in the summer semester of 2021. Behavioral health was assessed using validated instruments: the Patient Health Questionnaire-9 (PHQ-9) for depression and the Drug Abuse Screening Test-20 (DAST-20) for substance use. Demographic and behavioral variables were …
Cyber Science Education Meets Healthcare Technology, Angela Spencer
Cyber Science Education Meets Healthcare Technology, Angela Spencer
Journal of Cybersecurity Education, Research and Practice
The research investigates how cyber science education combines with healthcare technology during the digital age to resolve a fundamental research gap in these two advancing areas. A combined approach utilizing extensive surveys and detailed interviews evaluates the functionality of learning platforms as well as cybersecurity measures and potential uses of emerging virtual reality (VR) and augmented reality (AR) tools to improve both educational and clinical environments. The research document describes its methodologies thoroughly while. The research documents multiple quantitative and qualitative results before performing its analysis, which leads to strategy development for digit. The researchers worked to find ways that …
Youth Development Programs Critical Analysis, Rethinking Real Sustainability Measures. Focus On Middle-Eastern And African Contexts., Rasha As Salem
Youth Development Programs Critical Analysis, Rethinking Real Sustainability Measures. Focus On Middle-Eastern And African Contexts., Rasha As Salem
Theses and Dissertations
Abstract Using a systematic review of 18 research papers, policy documents, and evaluation reports, the study examines youth development programs sustainability through four aspects. First, the review explores how definitions of marginalized youth are applied in Middle East and African contexts. Furthermore, the review focuses on how programmatic suitability is discussed and implemented through the concepts of localization and contextualization. Additionally, the importance of locally grounded evidence as much as rigorous evidence and finally the implementation tactics. The review uses frameworks of ecological systems theory and empowering management approaches to analyze the data. The findings reveal significant variation in how …
Integration Of One Health Activities Into Professional Student Education: Successes, Challenges, And Considerations, Karen Gruszynski, Mary Beth Babos, Reagan Bishop, Debra Sullivan, Laroy Brandt
Integration Of One Health Activities Into Professional Student Education: Successes, Challenges, And Considerations, Karen Gruszynski, Mary Beth Babos, Reagan Bishop, Debra Sullivan, Laroy Brandt
All Faculty and Staff Scholarship
Interprofessional Education (IPE) creates opportunities for multiple disciplines to learn from each other and develop soft skills to improve patient care. One Health similarly emphasizes collaborative and interdisciplinary practice while recognizing the interconnectedness between human, animal, and environmental health. Despite the intersection of IPE and One Health, the meaningful integration of One Health within IPE remains uneven and difficult to operationalize. This perspective synthesizes experiences from multi-college programs implementing One Health-oriented IPE, highlighting successes, challenges, and structural requirements. We argue that for One Health to be successfully integrated into IPE for professional students, it requires extensive logistical planning, coordinated institutional …