Digital Commons Network^™

Hp1Β Recruits Ring1a To Ubiquitinate Histone H2a For Brca1-Mediated Resection Of Double-Stand Breaks, Vijaya Charaka, Raj K Pandita, Chi-Lin Tsai, Xiaoyan Wang, Sharmista Chakraborty, Kenneth S Ramos, Sandhik Nandi, Fransisca Leonard, Vipin Singh, Partha S Sarkar, Clayton R Hunt, John A Tainer, Chandrima Das, Tej K Pandita

Faculty, Staff and Student Publications

Efficient DNA double-strand break (DSB) repair by homologous recombination (HR), as initiated by BRCA1 recruitment orchestrated by histone and non-histone proteins, is critical to genome stability, replication, transcription, and cancer avoidance. Here we reveal Heterochromatin Protein1 beta (HP1β) promotes BRCA1 enrichment at DNA DSB sites in gene-rich regions, and this is impaired by HP1β depletion. We find that HP1β is specifically enriched at DSBs within gene-rich regions via its Chromo Shadow Domain (CSD) that interacts with both Chromatin Assembly Factor 1 and the RING1A ubiquitinase component of Polycomb Repressor Complex 1. The resulting protein complex facilitates BRCA1 recruitment by promoting …

Nci9673 (Part B): Etctn Randomized Phase Ii Study Of Nivolumab With Or Without Ipilimumab In Refractory, Metastatic Squamous Cell Carcinoma Of The Anal Canal, Van K Morris, Kristen K Ciombor, Lianchun Xiao, Joshua K Ochieng, Enrica Marmonti, Blase Polite, Benjamin A Weinberg, John C Krauss, John Hays, Sarbajit Mukherjee, Olivia Aranha, Syma Iqbal, Tony Shields, Al B Benson, Syed Kazmi, Christopher Lieu, Howard Hochster, Jennifer Whisenant, Cara Haymaker, Cathy Eng

Faculty, Staff and Student Publications

Purpose: In the previously completed NCI9673 (part A) single-arm study, the antiprogrammed death (PD)-ligand-1 antibody nivolumab demonstrated efficacy for patients with metastatic anal cancer. In NCI9673 (Part B), we evaluated the anticytotoxic T-cell lymphocyte antigen-4 (CTLA-4) antibody ipilimumab in combination with nivolumab for patients with incurable anal cancer.

Methods: In this phase II NCI ETCTN trial, 100 patients with refractory, incurable anal cancer were randomly assigned to receive nivolumab (480 mg IV once every 4 weeks) alone or with ipilimumab (1 mg/kg IV once every 8 weeks). The primary end point was progression-free survival (PFS). Secondary endpoints included radiographic response, …

2025 And 2026 - Faculty & Staff Research Symposium - Mini, Elizabeth Outka, Lidia Radi

Faculty and Staff Research Symposium Programs

September 26, 2025; November 7, 2025; January 20, 2026; and, February 20, 2026

[Excerpt from the "Welcome"]

"Dear Colleagues,

Welcome to the Faculty and Staff Mini-Symposia Series!

As we gather for the fourth and final installment of this year’s Mini-Symposia Series, we are delighted to continue this new chapter of the Faculty and Staff Research Symposium, building on the extraordinary enthusiasm of the past two years. What began as a single day of conversation and exchange has grown into a cycle of events designed to highlight the intellectual and creative work of our community in even more accessible and collaborative …

Steroid Receptor Coactivators - From Basic Research To Translational Opportunities, Yosef Gilad, Sang Jun Han, David M Lonard

Faculty, Staff and Students Publications

The concept of nuclear receptor (NR) coregulation was proposed nearly two decades before it was experimentally validated. According to this model, NRs - executors of a vast array of transcriptional programs - do not act independently but are governed by a network of regulatory proteins that either activate or repress their biological function. NRs identify the genes to be regulated. However, coregulators ultimately serve as the true controllers of transcriptional outcomes. They recruit cofactors and coordinate the activity of transcriptional complexes, thereby shaping NR-mediated gene expression beyond NRs' intrinsic functionality. The Steroid Receptor Coactivator (SRC) family is the most extensively …

Opportunities And Challenges In Synthetic Biology For Manufacture Of Bulk Chemicals, Xiaolin Shen, Qipeng Yuan

Bulletin of Chinese Academy of Sciences (Chinese Version)

Traditional chemical manufacturing, reliant on fossil resources, meets material demands but faces challenges such as resource depletion, environmental pollution, and carbon emissions. This underscores the urgent need for a shift towards green and sustainable production methods. Biomanufacturing, which uses renewable resources to produce chemicals, offers a promising pathway for the chemical industry’s green transition. In recent years, biomanufacturing has emerged as a key area of global attention. Through synthetic biology, bulk chemicals like 1,3-propanediol have been successfully produced. Nevertheless, biomanufacturing of bulk chemicals still faces significant challenges, including high costs, low efficiency, and limited scalability. This is particularly true for …

Addressing Population Aging: Innovative Approaches To Aging Research In China, Jingyi Li, Jinghui Lei, Qun Chu, Weiqi Zhang, Moshi Song, Yaojin Peng, Guanghui Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The increasing prevalence of aging and associated diseases poses a substantial challenge worldwide. In recent years, the field of aging research has achieved numerous breakthroughs. Nevertheless, challenges still persist. This study offers a comprehensive analysis of the advancements within China’s aging research, highlighting current challenges and proposing strategy and policy recommendations. These suggestions draw from various areas, including research paradigms and key issues, efficient resource management, development of essential technological research and innovation ecosystems, international collaboration, and considerations of ethics and governance. The aim is to provide valuable insights and guidance for enhancing the quality and impact of aging research …

2025issue2content

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

The Drosophila Him Gene Is Essential For Adult Muscle Function And Muscle Stem Cell Maintenance, Robert Mitchell-Gee, Robert Hoff, Kumar Vishal, Daniel Hancock, Sam Mckitrick, Cristina V. Newnes-Querejeta, Antonio Aguayo, David Liotta, Jennifer A. Waters, Ty Anna L. Lovato, Richard M. Cripps, Michael V. Taylor

Faculty Research, Scholarly, and Creative Activity

Muscle stem cells (MuSCs), or “satellite cells,” are vital for vertebrate muscle growth, homeostasis, and repair. The discovery of analogous cells in Drosophila opens experimental opportunities in this genetically tractable model. Here, we show that the myogenic inhibitor gene Him, as well as being expressed in the myoblasts that form the flight and jump muscles, is expressed in flight muscle MuSCs. This makes Him only the second marker of these insect adult MuSCs. Furthermore, Him mutants exhibit disrupted jump muscle organization, impaired jumping ability, and a reduced pool of flight muscle myoblasts. In the flight muscles themselves, Him mutants show …

The Teacher As Investigator: Improving The Education Of Migrant Students, Giuseppe Spadafora

Dewey Studies

No abstract provided.

A Deweyan Account Of Extrinsic Value And Its Relevance For The Anthropocene, Laurent Riou

Dewey Studies

No abstract provided.

Visceral Politics And Heuristic Democracy, Vincent M. Colapietro

Dewey Studies

No abstract provided.

Finding Your Public Voice, Annette Januzzi Wick

Creative Nonfiction Magazine

No abstract provided.

Silver Spaceships, Mary O'Connell

Creative Nonfiction Magazine

No abstract provided.

Renovations, Laura Pritchett

Creative Nonfiction Magazine

No abstract provided.

Monitoring Strategies In Cave Microclimate Studies, Nenad Buzjak, Dalibor Paar, Aurel Persoiu, Christos Pennos, Franci Gabrovšek, Valerija Rossi

International Journal of Speleology

Cave atmospheres are spatially confined but dynamical systems that influence subterranean ecosystems, geomorphological processes, registration and preservation of climatic signals in sedimentary archives, cultural heritage, and conservation management. Despite major advances in cave climatology, methodological approaches to microclimate monitoring remain fragmented and are in some cases still shaped by the long-standing assumption that cave air temperature simply reflects the mean annual surface temperature. This paper revisits that assumption and develops an experience- and literature-based methodological framework for cave microclimate research. Key terminology is addressed by distinguishing between cave climate, cave microclimate, and cave meteorology, and by situating microclimatic variability within …

My Brother Might Never Meet My Baby, Margaret Kimball

Creative Nonfiction Magazine

No abstract provided.

Our World, Ourselves, Clinton Crockett Peters

Creative Nonfiction Magazine

No abstract provided.

Beyond “Survival Of The Fittest”, Holly Haworth

Creative Nonfiction Magazine

No abstract provided.

Para, ​​Marisa L. Manuel

Creative Nonfiction Magazine

No abstract provided.

Reading Hair As A Document, Bhuva Narayan

Proceedings from the Document Academy

This paper is an exposition of the documental being, becoming, and unbecoming of hair, wherein I argue that although human hair is a corporeal material, and an object that can be viewed through various perspectives and theories, it can also be read as a document imbued with meaning, intention, and perception by humans, and fulfills Suzanne Briet’s criteria (Briet, 2006; Buckland, 1997) for an object to be considered a document: it has materiality (it must be a physical thing), intentionality (intended as evidence), needs processing (to be made part of a documentary system), and is an object of phenomenological perception …

The Documentality Of The American Passport, Melissa Adler

Proceedings from the Document Academy

This paper outlines an agenda for examining the passport in its emergence in the United States. In the earliest U.S. passports, there is already a paradox that mirrors American liberal democracy itself—a nation founded, in Thomas Jefferson’s words, in the vision of an “empire of liberty.” It lays the groundwork for working through the concept of and processes associated with documentality and what documents do, as well as for understanding the extraordinary conditions and implications associated with the inscription of human lives into documentary systems. Studying the emergence of passports within a broader documentary regime of American surveillance and …

Calibrating Humanness: Winding Our Own Springs—Comparing Human-Generated And Machine-Generated Response Documents, Jodi Kearns, Jennifer Davis

Proceedings from the Document Academy

The permanent exhibitions at the the National Museum of Psychology at The University of Akron, Ohio, USA, are arranged into three strands that tell a history of American psychology: the profession, the science, and the agent of social change. Visitors see historical objects and archival documents exploring such topics as the history of mental wellness treatment, immigration intelligence testing, study of behavior, gender identity, authority, sensory perceptions, animal studies, sensations, and violence. Before leaving the museum, visitors are invited to reflect on what they learned by responding to the following prompt by writing on a note card and leaving it …

The Robot As A Document For Action: Materiality And Corporeality In The Info-Communicational Approach To Robots, Cécile Payeur, Béa Arruabarrena

Proceedings from the Document Academy

This article explores the emerging materialities of mediating artifacts in the field of Human-Robot Interaction (HRI). Drawing on the evolution of documentary environments and the growing hybridization of digital and physical spaces, it extends documentary and communication theories to robots taking into account their socio-technical dimension and their info-communicational implications for human interactions. It posits that examining the robot as a mediating artefact of a documentary nature can enhance both the understanding and the design of collaborative logic in HRI. Using Manuel Zacklad's theoretical framework, Documents for Action (DoPA), the research conceptualizes the robot as a semiotic and mediating document …

Black Is The Body, Emily Bernard

Creative Nonfiction Magazine

No abstract provided.

Sheri Fink On Blending Science And Narrative, Lee Gutkind, Dan Sarewitz

Creative Nonfiction Magazine

No abstract provided.

Il-36Γ And The Development And Validation Of An Early Prediction Model For Severe Mycoplasma Pneumoniae Pneumonia In Children, Xiaodong Tang, Ying Li, Pao Yu, Wenpeng Wang, Bi Zhou

Journal of Pediatric Infectious Diseases

Objective: This study aimed to retrospectively analyze clinical data from pediatric patients with Mycoplasma pneumoniae pneumonia (MPP), investigate the expression and clinical significance of serum IL-36γ, and to develop and validate an early identification model for severe MPP (SMPP). Methods: Clinical data were collected from 345 children diagnosed with MPP in our department between July 1, 2023, and December 31, 2024. Based on diagnostic criteria, enrolled patients were categorized into an SMPP group (n=145) and a non-severe MPP (NSMPP) group (n=200). Serum IL-36γ levels at admission were measured using ELISA. Independent risk factors for SMPP were identified via binary logistic …

Expression Of Metrnl, Presepsin, And Bmp9 In Peripheral Blood Of Children With Sepsis And Their Roles In Diagnosis And Prognosis, Yang Liu, Cheng Wei

Journal of Pediatric Infectious Diseases

Objective: Meteorin-like protein (METRNL), soluble CD14 subtype (presepsin), and bone morphogenetic protein 9 (BMP9) show promising for sepsis diagnosis and prognosis assessment in children. Their diagnostic and prognostic utility is comprehensively assessed in this study. Methods: A total of 360 children, aged 3-14 years, with sepsis, infection, and healthy groups were retrospectively analyzed. Receiver Operating Characteristic curve evaluated the diagnostic performance of METRNL, presepsin, and BMP9 for sepsis. The 28-day prognostic information was collected for the sepsis group. Risk factors for poor prognosis in the sepsis group were analyzed using logistic regression. A nomogram prediction model for prognostic prediction in …

Hemodynamic And Oximetric Response To Sodium Bicarbonate Boluses In Children With Single Ventricle Parallel Circulation: A Retrospective, Single-Center Study, Fabio Savorgnan, Saul Flores, Rohit S. Loomba, Sebastian Acosta

Journal of Pediatric Intensive Care

Introduction: To evaluate the hemodynamic and oximetric changes in patients with parallel circulation (Norwood, hybrid, and BT-shunted) after sodium bicarbonate bolus administration. Methods: Retrospective analysis of physiologic data. To eliminate confounders, sodium bicarbonate boluses concurrently administered with normal saline, 5% albumin, epinephrine boluses, blood transfusions, change in VIS or mechanical circulatory support were excluded. Blood pressure, arterial oxygen saturation, heart rate, cerebral and renal NIRS were continuously recorded from one-hour pre to one-hour post each intervention. Results: Out of 429 boluses, 293 boluses met the inclusion criteria. Measurements show an increase in blood pressure (p = 0.01) and heart rate …

Unplanned Extubations In Pediatric Critical Care: A Case-Control Study, Krista Wollny, Cameron B. Williams, Raghad Al-Abdwani, Carol Cartelle, Jason Macartney, Helena Frndova, Norbert Chin, Christopher Parshuram

Journal of Pediatric Intensive Care

Objectives: To quantify associations between the risk of unplanned extubation and patient-, environment-, and care-related factors in pediatric critical care; and to compare outcomes between children who did and did not experience an unplanned extubation. Methods: Retrospective case-control analysis including patients <18 years who experienced an unplanned extubation during ICU admission (2004-2014). Cases were matched by age, duration of mechanical ventilation, and date to control-patients (4:1) who were intubated but did not experience an unplanned extubation. Conditional logistic regression was used to evaluate associations between unplanned extubations and the abstracted characteristics. Results: We identified 1601 eligible controls matched to 458 case-patients. When adjusted for confounders, eight variables were associated with unplanned extubation: three patient-related factors (previous ICU admission, previous intubation, and the volume of secretions); one environment-related factor (patient room set-up); and four care-related factors (intubation route, and the use of sedation, muscle relaxation and restraints). Patients who had an unplanned extubation had longer length of stay, but lower rate of mortality. Conclusions: This is the largest case-control study identifying variables associated with unplanned extubation in pediatric critical care. Several are potentially modifiable and may provide opportunities to improve quality of care in controlled ICU environments.

Outbound Investment Restrictions And International Law’S Challenge, Harlan Grant Cohen

Seattle University Law Review

The Outbound Investment Rule, restricting U.S. investment in certain Chinese advanced technology sectors, has largely been portrayed as an incremental measure, a modest extension to fill loopholes in the existing investment screening regime. But while perhaps the logical next step in the securitization of the economy, the Outbound Investment Rule actually reflects a momentous shift in the relationship between governments and business, one playing out in the United States and around the world and worth attention. Unlike traditional investment screening, the Outbound Investment Rule operates like a sanctions regime, designed not to protect the U.S. economy, but to hamper the …