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2026

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Kontroversi Pencabutan Gigi Permanen Muda Pada Perawatan Ortodonsi, Alifuddin Zuhri, Adam Malik Hamudeng, Ardiansyah S. Pawinru Mar 2026

Kontroversi Pencabutan Gigi Permanen Muda Pada Perawatan Ortodonsi, Alifuddin Zuhri, Adam Malik Hamudeng, Ardiansyah S. Pawinru

Dentofasial

Permanent tooth extraction in the children and teenager patients, either
due to of tooth decay or esthetical orthodontic reason, will have direct
effect to central nervous system and disturb the growth and
development process of the children and teenager patient's tooth and
jaw and indirect effect in closing of the opportunities of the patient
entering some vital job, like army cadet, pilot and stewardess. If
extraction is based on orthodontic analyses, there are at least 3 : new
problems will arise, namely neurological effect to central nervous
system, non-optimal occlusion and disturbance on growth and
development process of the patient …


Koreksi Protrusif Dengan Oral Screen Pada Anak Sebagai Tahap Terapi Awal Maloklusi Klas Ii Divisi 1, Muh. Harun Achmad Mar 2026

Koreksi Protrusif Dengan Oral Screen Pada Anak Sebagai Tahap Terapi Awal Maloklusi Klas Ii Divisi 1, Muh. Harun Achmad

Dentofasial

Malocclusion was a biological variation, which where happened deviate
from normal relations between teeth in one jaw arch and in the
contradictory jaw arch. Malocclusion was connected with thefunction
oftheface muscle, chewing muscles, andtongue muscles thatwas
abnormal. In a situation which anterior maxillary teeth were visible,
experienced pro verdigris, overbite, over jet that was too big, as well as
open bite. The main cause was possibly by disharmony of the relations
between oral and perioral muscles. One of the various early stages of
malocclusion in child therapy was mainly to correct the protrusive state
was the oral screen. This case …


Status Jaringan Periodontal Dan Kebutuhan Perawatan Jaringan Periodontal Pada Manula Suku Bugis Dan Suku Mandar, Bahruddin Thalib, Dian Angriani Mar 2026

Status Jaringan Periodontal Dan Kebutuhan Perawatan Jaringan Periodontal Pada Manula Suku Bugis Dan Suku Mandar, Bahruddin Thalib, Dian Angriani

Dentofasial

Being old is a biologic process that can not be avoided, where degeneration occurs in
many ways, which finally decreases the function. These cause aging people prone to
various diseases; including periodontal disease. Prevalence and severity of periodontal
diseases vary in world population. These differences seem to be related with age, sex,
socioeconomic, education, and also ethnic and geography. This study was aimed to
investigate the periodontal tissue of aging Buginese and Mandarnese. Total samples are
390 persons (195 Buginese dan 195 Mandarnese). The condition of periodontal tissue
were checked using CPITN from WHO. Of 195 samples, 88 samples of …


Kadar Tnf-α Dan Il-1β Cairan Sulkus Gingiva Setelah Pemasangan Mahkota Akrilik, Edy Machmud, Roswita Roswita Mar 2026

Kadar Tnf-α Dan Il-1β Cairan Sulkus Gingiva Setelah Pemasangan Mahkota Akrilik, Edy Machmud, Roswita Roswita

Dentofasial

Cervical margin of fixed denture either jacket crown or bridge, is usually placed
subgingivally for the natural look, however this can sometimes cause gingival
inflammation. Moreover, if the restoration material is acrylic, it sometimes can irritate
oral tissue. The aim of this study was to investigate the effect of acrylic, used as fixed
denture material, to gingival tissue reaction. This was an experimental study, using pre
and post test of 5 acrylic jacket crowns, made to patients in the Prosthodontic
Department, Dental Hospital of Hasanuddin University. Gingival crevicular fluid (GCF)
was collected before preparation, and three weeks after insertion of …


Efek Samping Radiasi Sinar X Dan Sinar Gamma Pada Daya Tahan Rongga Mulut, Barunawaty Yunus Mar 2026

Efek Samping Radiasi Sinar X Dan Sinar Gamma Pada Daya Tahan Rongga Mulut, Barunawaty Yunus

Dentofasial

No abstract provided.


Metode Dan Pertimbangan Untuk Melepas Restorasi Cekat Secara Konservatif, Eri H. Jubhari Mar 2026

Metode Dan Pertimbangan Untuk Melepas Restorasi Cekat Secara Konservatif, Eri H. Jubhari

Dentofasial

No abstract provided.


Pengaruh Propolis Terhadap Kolagenisasipada Proses Penyembuhan Luka Subkutan Punggung Mencit Yang Diinduksi Bakteri Actinobacillus Actinomycetemcomitans, Asdar Mar 2026

Pengaruh Propolis Terhadap Kolagenisasipada Proses Penyembuhan Luka Subkutan Punggung Mencit Yang Diinduksi Bakteri Actinobacillus Actinomycetemcomitans, Asdar

Dentofasial

No abstract provided.


Pengaruh Kumulatif Asap Rokok Dan Stres Terhadap Peningkatan Kadar Hormon Kortisol Mencit, Sumintarti S Mar 2026

Pengaruh Kumulatif Asap Rokok Dan Stres Terhadap Peningkatan Kadar Hormon Kortisol Mencit, Sumintarti S

Dentofasial

No abstract provided.


The Art Of Jussi Björling, Conrad L. Osborne Mar 2026

The Art Of Jussi Björling, Conrad L. Osborne

Journal of the Jussi Björling Societies of the USA & UK

Hello, everybody. Thanks to all of you looking in, and special thanks to Janel Lundgren, who extended the invitation to speak, to Walter Rudolph for hosting our event, to Steve Fischman for handling the sound fragments we’ll be hearing, and to my wife, Molly Regan,for all her help getting the fragments out to Steve. I’ve been following the activities of the Society at one degree of separation for many years, and have met or corresponded with several of you along the way, so I know I’m on home ground, among people as devoted as I am to keeping alive an …


Numerals And Other Means Of Expressing Plurality In Language And Thought: A Developmental Perspective Across Cultures., Giovanni Giuseppe G.G. Nicosia Prof. Mar 2026

Numerals And Other Means Of Expressing Plurality In Language And Thought: A Developmental Perspective Across Cultures., Giovanni Giuseppe G.G. Nicosia Prof.

Numeracy

Several ancient languages use linguistic structures to differentiate between singular, dual, and plural forms that are used when one, two, or many objects are referenced. (Some languages go further, adding a trial form to differentiate two from three.) In many modern languages, numerals are used to convey precise number. After reviewing a range of ways languages express number (including the interesting case of Pirahã which does not express precise number), the paper concludes with a proposed developmental path for the expression of quantity in languages.


Detection Of Phosphite Fungicide In Persea Americana Fruits Using Nuclear Magnetic Resonance (Nmr) Spectroscopy At 400 And 80 Mhz, Andres Bernal, Yimin Wang, Philipp Nitschke, Samuele Sala, Rance Kwamen, Andrea Steck, Birk Schuetz, Dario Stefanelli, Henry Brockman, Julien Wist, Jeremy K. Nicholson, Rueyleng Loo Mar 2026

Detection Of Phosphite Fungicide In Persea Americana Fruits Using Nuclear Magnetic Resonance (Nmr) Spectroscopy At 400 And 80 Mhz, Andres Bernal, Yimin Wang, Philipp Nitschke, Samuele Sala, Rance Kwamen, Andrea Steck, Birk Schuetz, Dario Stefanelli, Henry Brockman, Julien Wist, Jeremy K. Nicholson, Rueyleng Loo

Horticulture Research Articles

Nuclear magnetic resonance (NMR) spectroscopy is widely adopted for assessing biochemical composition in agriculture. This study evaluated the feasibility of 400 MHz NMR to detect biochemical differences in Hass avocados grown under conventional (N = 101) and regenerative (N = 105) farming practices in Southwestern Australia. Phosphite, associated with Phytophthora root rot management, was a key discriminating feature (area under ROC curve = 0.96), being detected in 90% of conventional avocados (mean: 49 mg/kg) and 6 regenerative samples (mean: 24 mg/kg). To assess translational potential, water extracts of five samples were analyzed using 80 MHz benchtop NMR. Phosphite was detectable …


March 4, 2026 Faculty Senate Minutes, University Of South Carolina Mar 2026

March 4, 2026 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.


The Student Movement Volume 110 Issue 16: Running, Biking, And Swimming Into Women's History Month, Addison Randall, Ysa Dennis, Melanie Webb, Anna Pak, Esther R. Knott, Laura Pérez, Madison Vath, Corinna Bevier Mar 2026

The Student Movement Volume 110 Issue 16: Running, Biking, And Swimming Into Women's History Month, Addison Randall, Ysa Dennis, Melanie Webb, Anna Pak, Esther R. Knott, Laura Pérez, Madison Vath, Corinna Bevier

The Student Movement V. 110 (2025-2026)

ARTS & ENTERTAINMENT

Creativity and Talent on Display at the AU Composers Concert, Addison Randall

The Idea of Patrick Bateman: Yuppie Culture and Misinterpreting Films, Ysa Dennis

Bringing Home Full Numbers: A Review of AUTW's 'Much Ado About Nothing', Melanie Webb

HUMANS

Students Serving Through Their Studies, Anna Pak

NEWS

Administration Announces Endowed Chair for Stephen Zork, Addison Randall

IDEAS

'Until I Make My Brothers Understand...', Esther R. Knott

PULSE

Students Explore Relationships with Purpose at Makarios First Spanish Small Group Meeting, Laura Pérez

Senioritis Through a Temporal Context, Madison Vath

LAST WORD

The True Story of How 'National Treasure' …


Seafood, Mercury, And Human Health In Coastal South Carolina: Findings From A Community-Based Study, Russell Fielding, Julia Saltzman, Rylee-Jade Bean, Jenna Monroe, Theodore R. Them Ii Mar 2026

Seafood, Mercury, And Human Health In Coastal South Carolina: Findings From A Community-Based Study, Russell Fielding, Julia Saltzman, Rylee-Jade Bean, Jenna Monroe, Theodore R. Them Ii

Honors College Faculty Publications

Mercury (Hg), an environmental pollutant, can harm human health. Seafood consumption is a major way that people are exposed to Hg and the analysis of human hair is a standard method to measure Hg exposure. This community-based study identified demographic and dietary factors associated with elevated Hg concentrations and health outcomes of individuals with elevated Hg concentrations throughout two coastal South Carolina (SC) counties. We collected hair samples (n = 85) at local barbershops and salons; participants completed an online survey with questions on demographics, diet, and health histories; and we analyzed hair samples using a DMA-80. Between 4.9–8.4% of …


Sensing Negative-Cone Rotational Diffusion Of Dipole-Like Emitters, Yuanxin Qiu, Kaizhi A. Nie, Matthew D. Lew Mar 2026

Sensing Negative-Cone Rotational Diffusion Of Dipole-Like Emitters, Yuanxin Qiu, Kaizhi A. Nie, Matthew D. Lew

Electrical & Systems Engineering Publications and Presentations

Fluorescence anisotropy and single-molecule orientation-localization microscopy (SMOLM) are powerful techniques that quantify the rotational diffusion of dipole-like emitters, which is important for sensing molecular interactions and chemical environments at the nanoscale. Numerous theoretical and experimental studies have thoroughly characterized single-molecule rotations even when those rotations are much faster than the detector integration time. Here, we extend the theory of measuring rotational diffusion to situations where a single dipole rotates uniformly everywhere outside of an isotropic cone of a certain size, termed a negative cone. This scenario corresponds to negative fluorescence anisotropy 𝑟 and has been observed in emitters exhibiting strong …


Epigenetic Activation Of Ebv Bglf4 Determines Antiviral-Based Regimen Response In Ebv+Cns Lymphoproliferative Disease, Christoph Weigel, Haley Klimaszewski, Fode Tounkara, Selamawit Addissie, Sarah Schlotter, Betsy Pray, James Dugan, Bradley Haverkos, Lynda Villagomez, Mark Lustberg, Pierluigi Porcu, Timothy Voorhees, Richard Ambinder, Shannon Kenney, Joyce Fingeroth, Henri-Jacques Delecluse, Michael Caligiuri, Lapo Alinari, Ginny Bumgardner, Christopher Oakes, Robert Baiocchi Mar 2026

Epigenetic Activation Of Ebv Bglf4 Determines Antiviral-Based Regimen Response In Ebv+Cns Lymphoproliferative Disease, Christoph Weigel, Haley Klimaszewski, Fode Tounkara, Selamawit Addissie, Sarah Schlotter, Betsy Pray, James Dugan, Bradley Haverkos, Lynda Villagomez, Mark Lustberg, Pierluigi Porcu, Timothy Voorhees, Richard Ambinder, Shannon Kenney, Joyce Fingeroth, Henri-Jacques Delecluse, Michael Caligiuri, Lapo Alinari, Ginny Bumgardner, Christopher Oakes, Robert Baiocchi

Kimmel Cancer Center Faculty Papers

Epstein-Barr virus (EBV)–associated primary central nervous system lymphoproliferative diseases (EBV+PCNSL) are aggressive conditions with poor prognoses. We previously reported durable responses in patients with PCNSL who were treated with the antivirals ganciclovir and azidothymidine, plus rituximab and dexamethasone (GARD). Responses were associated with the detection of the lytic viral protein kinases, BGLF4 and BXLF1. These antiviral activating kinases are associated with lytic EBV, however, the mechanism for expression in latently infected EBV+CNSL is unknown. Expanding on previous work, we provide long-term clinical outcome data (N = 24) and show that RNA expression analysis in CNSL tissue biopsies (n = 12) …


Mapping Fire Management: A Spatial Social Network Approach, Christoph Neger, Cody Evers, Kapil Yadav, Octavio Romero Cuapio Mar 2026

Mapping Fire Management: A Spatial Social Network Approach, Christoph Neger, Cody Evers, Kapil Yadav, Octavio Romero Cuapio

Environmental Science and Management Faculty Publications and Presentations

Maps are an essential tool to inform fire governance and management. For instance, they can highlight which areas are most vulnerable to adverse fire impacts or be used to plan interventions for risk reduction and prevention. In recent years, several studies have mapped the fire management activities and the networks between the multitude of involved actors. They build upon previous advances to combine quantitative and qualitative social network analysis with geographical analysis and cartography, aiming to highlight areas of opportunity to enhance fire governance. This paper continues this line of research, examining cooperation in fire management within the south-eastern part …


Sickle Cell Visualization In Vivo In Humans: Microvascular Occlusion Formation And Hemorheological Indices, Marisa M Morakis, Luojie Huang, Gregory N. Mckay, Sophie Lanzkron, Lydia H. Pecker, Nicholas J. Durr Mar 2026

Sickle Cell Visualization In Vivo In Humans: Microvascular Occlusion Formation And Hemorheological Indices, Marisa M Morakis, Luojie Huang, Gregory N. Mckay, Sophie Lanzkron, Lydia H. Pecker, Nicholas J. Durr

Cardeza Foundation for Hematologic Research

Vaso-occlusion is a signature pathology of sickle cell disease (SCD). However, the lack of in vivo methods to observe individual blood cell dynamics in humans limits our understanding of occlusion formation mechanisms. We present a novel in vivo, noninvasive, label-free, and high-resolution imaging technique to study blood flow and sickled cell behavior in affected individuals. We used oblique back-illumination microscopy (OBM) to capture videos of 91.0 ± 42.3 sublingual capillaries in each of 10 participants with SCD before and after red cell transfusions and compared the measurements to 10 unaffected controls. With direct observation of blood cell activity, we identified …


Childhood Maltreatment And Deviations From Normative Brain Structure: A Mega-Analysis Of 3,711 Individuals From The Enigma Mdd And Enigma Ptsd Working Groups, Haley R Wang, Zhen-Qi Liu, Elena Pozzi, Ahmed Hussain, Priyanka Sigar, Chadi Abdallah, Nina Alexander, Justin Baker, Jochen Bauer, Jennifer Urbano Blackford, Josh Cisler, Colm G Connolly, Andrew Cotton, Judith Daniels, Udo Dannlowski, Maria Densmore, Terri Deroon-Cassini, Danai Dima, Stefan Du Plessis, Amit Etkin, Negar Fani, Lukas Fisch, Jacklynn Fitzgerald, Thomas Frodl, Cynthia H Y Fu, Ali Saffet Gonul, Evan M Gordon, Ian Gotlib, Roberto Goya-Maldonado, Nynke A Groenewold, Dominik Grotegerd, Tim Hahn, J Paul Hamilton, Laura Han, Ilan Harpaz-Rotem, Courtney C Haswell, Ryan Herringa, Julia Herzog, Jonathan Ipser, Neda Jahanshad, Tanja Jovanovic, Milissa Kaufman, Tilo Kircher, Maximilian Konowski, Sheri-Michelle Koopowitz, Axel Krug, John Krystal, Ruth Lanius, Christine Larson, Amit Lazarov, Lauren Lebois, Elisabeth Leehr, Ifat Levy, Meng Li, Antje Manthey, Adi Maron-Katz, Andrew Mcintosh, Katie Mclaughlin, Susanne Meinert, Benson Mwangi, Steven M Nelson, Igor Nenadić, Yuval Neria, Richard Neufeld, Amar Ojha, Bunmi Olatunji, Elizabeth A Olson, Nils Opel, Matthew Peverill, Kerry Ressler, Marisa Ross, Isabelle Rosso, Matthew Sacchet, Kelly Sambrook, Christian Schmahl, Soraya Seedat, Martha E Shenton, Maurizio Sicorello, Anika Sierk, Jair C Soares, Dan J Stein, Frederike Stein, Murray B Stein, Benjamin Suarez-Jimenez, Jean Théberge, Sophia I Thomopoulos, Carissa Tomas, Paula Usemann, Leigh L Van Den Heuvel, Sanne Van Rooij, Henrik Walter, Martin Walter, Xin Wang, Heather Whalley, Nils R Winter, Mon-Ju Wu, Hong Xie, Tony Yang, Xi Zhu, Sigal Zilcha-Mano, Giovana B Zunta-Soares, Sophia Frangou, Paul M Thompson, Lauren Salminen, Delin Sun, Rajendra Morey, Jennifer S Stevens, Lianne Schmaal, Tiffany C Ho Mar 2026

Childhood Maltreatment And Deviations From Normative Brain Structure: A Mega-Analysis Of 3,711 Individuals From The Enigma Mdd And Enigma Ptsd Working Groups, Haley R Wang, Zhen-Qi Liu, Elena Pozzi, Ahmed Hussain, Priyanka Sigar, Chadi Abdallah, Nina Alexander, Justin Baker, Jochen Bauer, Jennifer Urbano Blackford, Josh Cisler, Colm G Connolly, Andrew Cotton, Judith Daniels, Udo Dannlowski, Maria Densmore, Terri Deroon-Cassini, Danai Dima, Stefan Du Plessis, Amit Etkin, Negar Fani, Lukas Fisch, Jacklynn Fitzgerald, Thomas Frodl, Cynthia H Y Fu, Ali Saffet Gonul, Evan M Gordon, Ian Gotlib, Roberto Goya-Maldonado, Nynke A Groenewold, Dominik Grotegerd, Tim Hahn, J Paul Hamilton, Laura Han, Ilan Harpaz-Rotem, Courtney C Haswell, Ryan Herringa, Julia Herzog, Jonathan Ipser, Neda Jahanshad, Tanja Jovanovic, Milissa Kaufman, Tilo Kircher, Maximilian Konowski, Sheri-Michelle Koopowitz, Axel Krug, John Krystal, Ruth Lanius, Christine Larson, Amit Lazarov, Lauren Lebois, Elisabeth Leehr, Ifat Levy, Meng Li, Antje Manthey, Adi Maron-Katz, Andrew Mcintosh, Katie Mclaughlin, Susanne Meinert, Benson Mwangi, Steven M Nelson, Igor Nenadić, Yuval Neria, Richard Neufeld, Amar Ojha, Bunmi Olatunji, Elizabeth A Olson, Nils Opel, Matthew Peverill, Kerry Ressler, Marisa Ross, Isabelle Rosso, Matthew Sacchet, Kelly Sambrook, Christian Schmahl, Soraya Seedat, Martha E Shenton, Maurizio Sicorello, Anika Sierk, Jair C Soares, Dan J Stein, Frederike Stein, Murray B Stein, Benjamin Suarez-Jimenez, Jean Théberge, Sophia I Thomopoulos, Carissa Tomas, Paula Usemann, Leigh L Van Den Heuvel, Sanne Van Rooij, Henrik Walter, Martin Walter, Xin Wang, Heather Whalley, Nils R Winter, Mon-Ju Wu, Hong Xie, Tony Yang, Xi Zhu, Sigal Zilcha-Mano, Giovana B Zunta-Soares, Sophia Frangou, Paul M Thompson, Lauren Salminen, Delin Sun, Rajendra Morey, Jennifer S Stevens, Lianne Schmaal, Tiffany C Ho

Faculty, Staff and Student Publications

Background: Childhood maltreatment (CM), encompassing abuse and neglect, is highly prevalent and associated with elevated risk for Major Depressive Disorder (MDD), Posttraumatic Stress Disorder (PTSD), and other related conditions. The extent to which neuroanatomical alterations in MDD and PTSD are attributable to CM, however, is uncertain.

Methods: Here, we analyzed CM and whole-brain MRI data from 3,711 participants in the ENIGMA MDD and PTSD Working Groups (25 sites; 33.3±13.0 years; 59.9% female). Normative modeling estimated deviation z-scores for 14 subcortical volumes (SV), 68 cortical thickness (CT), and 68 surface area (SA) measures. To identify transdiagnostic effects, associations between CM and …


Artificial Sentience: The Other Side Of The Story, Amanda Sharkey Mar 2026

Artificial Sentience: The Other Side Of The Story, Amanda Sharkey

Animal Sentience

There is another side to the story of the account of artificial sentience — one that makes the possibility of artificial sentience unlikely: the fundamental difference between living bodies and artificial systems.  Sentience occurs in strongly embodied, living entities, and not in disembodied artificial systems, nor in robots. The appearance of sentience is exacerbated by deceptive behaviour and anthropomorphism. The risks of keeping an open mind about the required underlying substrate are in wasted efforts to protect systems that cannot suffer, and in placing inappropriate trust in their abilities.


Neuromodulating Mammals For Military Operations: Ethical Responsibility And Governance In Security Domains, Elise Annett, James Giordano Mar 2026

Neuromodulating Mammals For Military Operations: Ethical Responsibility And Governance In Security Domains, Elise Annett, James Giordano

Strategic Insights

This commentary examines ethical and governance challenges associated with the potential use of neurotechnology to influence the behavior of marine mammals for military purposes. While the use of dolphins and sea lions in naval operations has historical precedent, reports suggesting that advanced neurotechnologies may be used to modulate or control the behavior of orcas represent a significant ethical and legal inflection point. Invasive neuromodulation techniques, such as implantable neural interfaces, pharmacological modulation, or remote stimulation raise serious concerns about animal welfare, agency, and the potential dual-use implications of neurotechnology. Stronger governance frameworks, including international dialogue, Department of War policy guidance, …


The Medicinal Landscape Of Chrysanthemum Indicum L.: Bridging Traditional Wisdom And Modern Evidence, Gavin Liu, Elena Alexa, Tao Zhang Mar 2026

The Medicinal Landscape Of Chrysanthemum Indicum L.: Bridging Traditional Wisdom And Modern Evidence, Gavin Liu, Elena Alexa, Tao Zhang

Research Outputs: 2025-Present

Chrysanthemum indicum L. (C. indicum), a perennial herb widely distributed across East Asia,has long been utilised in traditional medicine and as a functional food ingredient. Contemporaryresearch has revealed a chemically diverse phytochemical profile, dominated byflavonoids, phenolic acids, sesquiterpene lactones, essential oils, carotenoids, and polysaccharides,which collectively underpin its broad pharmacological potential. Experimentalstudies demonstrate that extracts and isolated constituents of C. indicum exert pronouncedantioxidant, anti-inflammatory, antimicrobial, hepatoprotective, cardioprotective, and anticancereffects in vitro and in vivo, often through modulation of key molecular pathwayssuch as NF-κB, NLRP3 inflammasomes, AMPK–SIRT1, and Nrf2 signalling. Emergingpharmacokinetic evidence indicates variable oral bioavailability and metabolic transformationof major bioactive compounds, …


Modulating Alternative Splicing Of Mecp2 Is A Potential Therapeutic Strategy For Rett Syndrome, Harini P Tirumala, Li Wang, Yan Li, Sameer S Bajikar, Ashley G Anderson, Wei Wang, Alexander J Trostle, Mahla Zahabiyon, Aleksandar Bajic, Jean J Kim, Hu Chen, Zhandong Liu, Huda Y Zoghbi Mar 2026

Modulating Alternative Splicing Of Mecp2 Is A Potential Therapeutic Strategy For Rett Syndrome, Harini P Tirumala, Li Wang, Yan Li, Sameer S Bajikar, Ashley G Anderson, Wei Wang, Alexander J Trostle, Mahla Zahabiyon, Aleksandar Bajic, Jean J Kim, Hu Chen, Zhandong Liu, Huda Y Zoghbi

Faculty, Staff and Students Publications

Rett syndrome (RTT) is a neurological disorder caused by loss-of-function mutations in methyl CpG binding protein 2 (MECP2), a transcriptional regulator essential for maintenance of normal neuronal function. The current FDA-approved treatment for RTT, Trofinetide, mildly alleviates some symptoms. In contrast, re-introducing MeCP2 or increasing its amount through transgenesis in mouse RTT models improves most neurological phenotypes and enhances survival. Here, we devised a therapeutic strategy to moderately increase MeCP2 protein by modulating the alternative splicing of MECP2 to switch the less efficiently translated e2 to the more efficiently translated e1 isoform. We deleted Mecp2 exon 2 (unique …


Volume 12, 2025 Mar 2026

Volume 12, 2025

James Madison Undergraduate Research Journal (JMURJ)

No abstract provided.


Michigan Tech’S Insect Collection: An Important Historical Resource In The Upper Peninsula, Thomas E. Panella, Tara L. Bal Mar 2026

Michigan Tech’S Insect Collection: An Important Historical Resource In The Upper Peninsula, Thomas E. Panella, Tara L. Bal

The Great Lakes Entomologist

Regional insect collections can be valuable resources when covering under-represented areas, unique time periods, or unique collectors. Houghton and Baraga County Michigan are two predominantly forested counties in the Upper Peninsula (UP) of Michigan. The main campus for Michigan Technological University is based in Houghton, MI with a forestry field campus in Baraga County that was acquired in 1954. The university has had forest entomology research in some capacity at least since the 1930’s with faculty, students, and members of the community preserving and submitting various specimens in the decades since then, making it a unique collection demographically. The collection …


Dawn To Dusk Division Of Monarda Fistulosa Foraging Time By Bumble Bee Species (Bombus Spp.) And Likelihood To Return The Next Day, Elise Bernstein, Clara Costello, Mary Yang, Rosa Weinand, Noah Sullivan, Maya Cintorino, Charlie Vang, Miller Johnson, Ahmed Hussein, Gaochong Vang, Rashad Bowen, Kristen Gresl, Elaine Evans Mar 2026

Dawn To Dusk Division Of Monarda Fistulosa Foraging Time By Bumble Bee Species (Bombus Spp.) And Likelihood To Return The Next Day, Elise Bernstein, Clara Costello, Mary Yang, Rosa Weinand, Noah Sullivan, Maya Cintorino, Charlie Vang, Miller Johnson, Ahmed Hussein, Gaochong Vang, Rashad Bowen, Kristen Gresl, Elaine Evans

The Great Lakes Entomologist

There is a growing public interest in increasing pollinator habitat in urban areas. Monarda fistulosa is a commonly planted perennial species chosen for pollinator habitats of various sizes, from residential gardens to large-scale prairie restoration projects. Previous research has confirmed a preference for M. fistulosa among various bee species. We monitored and marked bumble bees visiting M. fistulosa over a 14-hour period, seeking to understand the daily pattern of bee visitation. We also observed bumble bees on the following day to determine the probability of marked individual bumble bees continuing to forage on M. fistulosa or to switch to a …


New Records Of The American Bumble Bee, Bombus Pensylvanicus, In Michigan, Sharron Z. Miller, Logan M. Rowe, Lillyanna Widdicombe, Robert P. Jean, Rufus Isaacs Mar 2026

New Records Of The American Bumble Bee, Bombus Pensylvanicus, In Michigan, Sharron Z. Miller, Logan M. Rowe, Lillyanna Widdicombe, Robert P. Jean, Rufus Isaacs

The Great Lakes Entomologist

We report recent detections of the American bumble bee, Bombus pensylvanicus (De Geer) (Hymenoptera: Apidae), in 16 counties of Michigan, USA. This bee species is currently listed as state endangered in Michigan. The current report provides an update on the distribution of B. pensylvanicus in Michigan from collections made between 2020 and 2024, including detections from at least 21 locations in the Lower Peninsula, expanding the known distribution in this state. These samples were from four pollinator survey projects with records from photographs and collections and two online participatory science programs where users uploaded photographs of this species while verified …


Assessing The Performance Of A 3d Printed Pennsylvania-Style Black Light Moth Trap, Christopher B. Brown, Eva S. Conley, Peter White Mar 2026

Assessing The Performance Of A 3d Printed Pennsylvania-Style Black Light Moth Trap, Christopher B. Brown, Eva S. Conley, Peter White

The Great Lakes Entomologist

Passive light traps have long been a popular method used for trapping moths and other night-flying insects. Recent changes in the availability of equipment necessitate the development of accessible and effective alternatives for insect monitoring. This study assesses the performance of a 3D-printed Pennsylvania-style black light moth trap compared to the formerly available commercial BioQuip trap and investigates the impact of funnel size on catch rates. Our 3D-printed trap was compared to the BioQuip trap over ten trap-nights in Central Michigan. Results indicate that commercial BioQuip traps consistently captured significantly more moths than the 3D-printed prototype. An additional experiment evaluating …


Geography Of Periodical Cicadas (Hemiptera: Cicadidae) In Portions Of Northeast Illinois And Northwest Indiana, Carl A. Strang Mar 2026

Geography Of Periodical Cicadas (Hemiptera: Cicadidae) In Portions Of Northeast Illinois And Northwest Indiana, Carl A. Strang

The Great Lakes Entomologist

Brood XIII periodical cicadas (Magicicada Davis) in DuPage County, Illinois, emerged in 2024 in an area that extended as much as 10.6 km beyond the edge of the previous main emergence in 2007. The implied dispersal of gravid females is greater than has been reported elsewhere and may reflect adaptation to a historical landscape of scattered wooded islands within a matrix of prairie. A series of four-year-early emergences in northeast Illinois, first described in print in 1969 and subsequently occurring prior to each succeeding main emergence, was quantified for the first time in 2020. The largest densities of singing …


Biology, Phenology, And Host Range Of A Seed-Feeding Weevil, Ceutorhynchus Constrictus (Coleoptera: Curculionidae), A Biological Control Agent For Garlic Mustard, Alliaria Petiolata, In North America, Ghislaine Cortat, Hariet L. Hinz, Esther Gerber, Elizabeth J. Katovich, Mary E. Marek-Spartz, Roger L. Becker, Robert S. Bourchier, Danielle Fife Mar 2026

Biology, Phenology, And Host Range Of A Seed-Feeding Weevil, Ceutorhynchus Constrictus (Coleoptera: Curculionidae), A Biological Control Agent For Garlic Mustard, Alliaria Petiolata, In North America, Ghislaine Cortat, Hariet L. Hinz, Esther Gerber, Elizabeth J. Katovich, Mary E. Marek-Spartz, Roger L. Becker, Robert S. Bourchier, Danielle Fife

The Great Lakes Entomologist

Ceutorhynchus constrictus Marsham is a seed-feeding weevil and potential biocontrol agent of the invasive plant garlic mustard, Alliaria petiolata (Bieb.) Cavara & Grande (Brassicaceae), in North America. Ceutorhynchus constrictus is native to Europe, has a single generation per year and eggs are laid into developing seeds within the seedpods of bolting garlic mustard plants. Females use their prolonged rostrum to bore holes through seedpods into the developing seed, deposit a single egg and then cover the opening with secretion. Larvae feed on ripening seeds and progress through three instars before exiting seedpods in late June, to pupate and overwinter in …