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2026

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Neonatal Septicemia In Al_Najaf Al_Ashref Governerate : Bacteriological Profile And Antimicrobial Sensitivity, Adnan H. Al-Hamadani, Adel H. Sheeh, Sinaa Abdulamir Al-Zubaidy Mar 2026

Neonatal Septicemia In Al_Najaf Al_Ashref Governerate : Bacteriological Profile And Antimicrobial Sensitivity, Adnan H. Al-Hamadani, Adel H. Sheeh, Sinaa Abdulamir Al-Zubaidy

Al-Qadisiyah Medical Journal

Neonatal septicemia still one of the most important causes of neonatal sepsis and death. Knowledge of bacteriological profile and antibacterial sensitivity pattern in our locality play an important role in selection of antibacterial drug that will be very effective against causative pathogens.This study conducted in AL- NAJAF AL- ASHREF Governorate during period extended between Nov.2007 to Feb.-2008, about 57 clinically suspected cases of neonatal septicemia was enrolled, to study bacteriological profile and antibiotic sensitivity pattern. Results showed that 33 cases (58 %) gave positive blood culture results and there was no growth in 24 cases (42 %), from the positive …


In Vitro Study For The Effect Of Cinnamon Oil On Multi-Drug Resistant Staphylococcus Aureus And Proteus Mirabilis Strains, Israa Kitab Al -Yasiri Mar 2026

In Vitro Study For The Effect Of Cinnamon Oil On Multi-Drug Resistant Staphylococcus Aureus And Proteus Mirabilis Strains, Israa Kitab Al -Yasiri

Al-Qadisiyah Medical Journal

The study was carried out to assess the effect of cinnamon oil on multi-drug resistant (MDR) strains of Staphylococcus aureus and Proteus mirabilis isolated from patient infected with otitis media. 50 specimens were collected at AL Hakeem Teaching Hospital in AL-Najaf governorate, 20 isolates were found to be Staphylococcus spp. and Proteus spp. on further studying for the species level only six of these isolates were found to be multi-drug resistant Staphylococcus aureus and Proteus mirabilis. The results of antibiotic sensitivity testing showed that most of these isolates were highly resistant (resistance percentage was 40-90%) for the used antibiotics. The …


Epidemiologic Study Of Opportunistic Fungi Contaminating Soil Of Schools, Mosques And Hotels In Diwaniya City - Iraq, Adnan H Al-Hamdani, Mohammad A.Al-Shammary, Rana S. Jabbar Mar 2026

Epidemiologic Study Of Opportunistic Fungi Contaminating Soil Of Schools, Mosques And Hotels In Diwaniya City - Iraq, Adnan H Al-Hamdani, Mohammad A.Al-Shammary, Rana S. Jabbar

Al-Qadisiyah Medical Journal

Soil mycoflora in several schools, mosques and hotels in Diwaniya city were examined using dilution plate technique and three different culture media with and without supplementation of cycloheximide antifungal. A total number of fungal isolates observed in all experiments were 2589 that represent 57 species related to 48 genus, in addition to the white and dark sterile mycelium. Cycloheximide substantially affected the frequency of isolated fungi. Where Penicillium chrysogenum was the most frequent species (44.73%) on culture media free from cycloheximide. Acremonium kiliense was the most with more capability than other examined fungi in tested blood which took 3 days …


Acomparative Study Of Depression Among Patients With Hip Fracture With Psychiatric Depressive Patients, Abdul Zahra Al-Khafagi, Ihssan Abdul Abbas, Mossa O. Mossa Algazali Mar 2026

Acomparative Study Of Depression Among Patients With Hip Fracture With Psychiatric Depressive Patients, Abdul Zahra Al-Khafagi, Ihssan Abdul Abbas, Mossa O. Mossa Algazali

Al-Qadisiyah Medical Journal

A total (50)patients with hip fracture, admitted to the Al-Diwaniya teaching hospital were screened for the depression and those fitting the criterion for the depression were studied further. 32% of the patients with the hip fracture met the criterion for the depression based on DSMIV. (1) The occurrence of depression and course appeared closely bound up with hip fracture, when compared with depression in (100)psychiatric depressed patients, the hip fracture depressed patients were less severely depressed, less guilty feeling and suicidal, but show sever anxiety, refamdation and helplessnessObjectivesTo determine the prevalence of depression among the patients with fracture around the …


The Effect Of Aqueous And Alcoholic Extracts Of Fruit Pell Of Punica Granutum Against Leishmania Major In Vitro And In Vivo, A. H. H. Awad, H. M. Jarallah, A. H. Jassim Mar 2026

The Effect Of Aqueous And Alcoholic Extracts Of Fruit Pell Of Punica Granutum Against Leishmania Major In Vitro And In Vivo, A. H. H. Awad, H. M. Jarallah, A. H. Jassim

Al-Qadisiyah Medical Journal

The effects of aqueous and alcoholic extract of Punica granatum, were studied against the activity and growth of promastigote of Leishmania major in vitro. The alcoholic extract was used by topical route against BALB/c mice infected with L.major. The alcoholic extract showed high activity against L.major promastigote than aqueous extract.


The Risk Of Infertility In The Chlamydial Vaginal Infection, Manal Mohammed Kadhim Al-Saadi Mar 2026

The Risk Of Infertility In The Chlamydial Vaginal Infection, Manal Mohammed Kadhim Al-Saadi

Al-Qadisiyah Medical Journal

Across-section study carried on 100 women attended the Maternity and Child Teaching Hospital and certain public clinics in Diwanyia city from the first of march 2005 to the end of August 2005 ,and complete medical history was taken from each one ,then a serological test was done by using Chlamydial Kit (Biorapid Chlamydia antigen)to identify the rate of infection with Chlamydia and its correlation with risk of infertility in women .The study was revealed that the prevalence rate of chlamydial infection was 26% among women ,and there is an risk factor or Odds ratio (OR) =6 to produce infertility among …


Effect Of Captopril And Enalapril On Selected Coagulation Markers In Hyperlipidemia, Bassim Irheim Al Sheibani Mar 2026

Effect Of Captopril And Enalapril On Selected Coagulation Markers In Hyperlipidemia, Bassim Irheim Al Sheibani

Al-Qadisiyah Medical Journal

Background: In addition to their primary indications, hypertension and congestive heart failure, angiotensin converting enzyme inhibitors, ACE-Is, have pleiotropic effects, which are under active investigations. There is growing evidence of data stating the significant role of ACE-Is in the regulation of hemostasis.Objectives: The present study aimed to evaluate the effect of ACEIs on coagulation in hyperlipidemia.Materials and Methods: Twenty-eight male Sprague-Dawely rats aged 17-19 weeks were enrolled in this study. The animals were randomized into four groups each containg seven rats: group1, 2,3 and 4. Group 1 was fed a standard chow diet and serve as normal diet control while …


Bridging The Gender Gap In Cardiovascular Care: A Framework For Women's Heart Care, Julia Grapsa, Ana G Almeida Mar 2026

Bridging The Gender Gap In Cardiovascular Care: A Framework For Women's Heart Care, Julia Grapsa, Ana G Almeida

Saudi Medical Journal

No abstract provided.


Specificities Of Aortic Stenosis In Women – From Diagnosis To Management, Yasser Harb, Fadi Tohme, Hadi Ossaili, Karim Halabi, Ali Kanso, Elie Chammas, Samer Nasr, Mohammad Tahini, Nicole Karam Mar 2026

Specificities Of Aortic Stenosis In Women – From Diagnosis To Management, Yasser Harb, Fadi Tohme, Hadi Ossaili, Karim Halabi, Ali Kanso, Elie Chammas, Samer Nasr, Mohammad Tahini, Nicole Karam

Saudi Medical Journal

Aortic stenosis (AS) is the most common valvular heart disease worldwide, with pathophysiology, clinical presentation, and management differing widely according to sex. Women demonstrate predominantly fibrotic valve modifications and less calcifications for given hemodynamic severity, with left ventricular concentric hypertrophy and smaller cavity size leading to a higher prevalence of paradoxical low-flow, low-gradient AS. These sex differences are modulated by hormonal changes, inflammatory and metabolic pathways, as well as genetic and epigenetic regulators. Atypical symptoms and hemodynamic specificities on echocardiography all combine to create diagnostic challenges that contribute to delayed recognition and intervention. Multimodality imaging, particularly the use of sex-specific …


Women’S Cardiovascular Health In 2025: Advancements Achieved, Challenges Ahead, Jamilah S. Alrahimi Mar 2026

Women’S Cardiovascular Health In 2025: Advancements Achieved, Challenges Ahead, Jamilah S. Alrahimi

Saudi Medical Journal

Cardiovascular disease (CVD) is the leading cause of death among women globally. Recognition of sex-specific risk factors, pathophysiology, and clinical presentations has established women's cardiovascular health as a research and clinical priority. Pregnancy complications, premature menopause, and autoimmune disease, are now identified as long-term contributors to cardiovascular risk, while female-predominant syndromes such as ischemia with non-obstructive coronary arteries and heart failure with preserved ejection fraction are increasingly acknowledged. Novel therapies and updated guidelines emphasize psychosocial determinants, reproductive history, and postpartum risk assessment in prevention and management. Despite these advances, women remain underdiagnosed, undertreated, and underrepresented in clinical trials. Diagnostic delays …


Investigating The Use Of Antidepressants In Treating Major Depressive Disorder: Insights From A Retrospective Study In Saudi Arabia, Hassan A Alsaad, Wajd A Alfaraj, Maryam M Alrababi, Ali M Sonbaa, Dalal M Albakr, Ali Saleh Abensaad, Fadhel A Alomar Mar 2026

Investigating The Use Of Antidepressants In Treating Major Depressive Disorder: Insights From A Retrospective Study In Saudi Arabia, Hassan A Alsaad, Wajd A Alfaraj, Maryam M Alrababi, Ali M Sonbaa, Dalal M Albakr, Ali Saleh Abensaad, Fadhel A Alomar

Saudi Medical Journal

Objectives: To investigate patterns of antidepressant prescribing and continuation rates among patients with major depressive disorder (MDD) in Saudi Arabia and to identify factors associated with treatment persistence. Method: A retrospective study was conducted at King Fahad Hospital of the University between May 2023 and February 2025. Data on patients' demographic characteristics, diagnostic information, and prescribed medications were collected. Initial antidepressant therapy and treatment continuation were evaluated, and potential influencing factors were analyzed. Results: Selective serotonin reuptake inhibitors (SSRIs) accounted for most first-line prescriptions (71%), followed by SSRI/atypical combinations (11%) and serotonin–norepinephrine reuptake inhibitors (SNRIs) (5%). Of the 220 patients …


Prognostic Significance Of Lymphovascular Invasion In Breast Cancer: Insights From A Retrospective Analysis At A Tertiary Care Center, Nora Trabulsi, Shayma Alotaibi, Mohammed Bahabri, Hussain A. Alkhalifah, Ghady D. Alshehri, Sultan K. Alshali, Ali Farsi, Marwan Alhajeili, Hassan Al-Turki, Salma Sait, Alaa Shabkah, Rana Ajaboor, Hessa Aljhdali Mar 2026

Prognostic Significance Of Lymphovascular Invasion In Breast Cancer: Insights From A Retrospective Analysis At A Tertiary Care Center, Nora Trabulsi, Shayma Alotaibi, Mohammed Bahabri, Hussain A. Alkhalifah, Ghady D. Alshehri, Sultan K. Alshali, Ali Farsi, Marwan Alhajeili, Hassan Al-Turki, Salma Sait, Alaa Shabkah, Rana Ajaboor, Hessa Aljhdali

Saudi Medical Journal

Objective: To explore the relationship between lymphovascular invasion (LVI) and outcomes across different histopathological subtypes, tumor grades, clinical stages, hormone receptor profiles, and treatment modalities. Lymphovascular invasion is a well-recognized histopathological feature associated with tumor dissemination in breast cancer. However, its prognostic weight is under-reported in Middle Eastern cohorts. Methods: We retrospectively reviewed data from 828 women treated for invasive breast carcinoma at King Abdulaziz University Hospital from 2010 to 2020. Clinicopathologic variables, treatments, and outcomes were extracted. Overall survival (OS) and event-free survival (EFS) were estimated and tested using Kaplan–Meier curves; independent predictors were identified with stepwise Cox models. …


Sleep Disorder Phenotypes And The Risk Of Incident Heart Failure: A Meta-Analysis With Mendelian Randomization Validation, Fang Yan, Lihua Fan, Yunhu Chen Mar 2026

Sleep Disorder Phenotypes And The Risk Of Incident Heart Failure: A Meta-Analysis With Mendelian Randomization Validation, Fang Yan, Lihua Fan, Yunhu Chen

Saudi Medical Journal

Objectives: To quantify how specific sleep-disorder phenotypes are related to incident heart failure (HF) using a meta-analysis of cohort data and to probe causal relevance via 2-sample Mendelian randomization (MR). Methods: Fourteen cohorts comprised of participants without HF at baseline were pooled (49,501 exposed; 337,317 controls). A random effects meta-analysis produced pooled hazard ratios (HRs) with 95% confidence intervals (CIs). A bidirectional two-sample MR was used to evaluate the causal effects of sleep phenotypes on HF. Results: Overall, sleep disorders were linked to a higher incidence of HF (pooled HR 1.46; 95% CI 1.30–1.63; pp < 0.001), whereas insomnia was not independently associated with HF (pooled HR 1.11; 95% CI 0.75–1.62; p = 0.609). The …


Addendum No. 5: Fog Integration, Vesa Olavi Lius Mar 2026

Addendum No. 5: Fog Integration, Vesa Olavi Lius

Defensive Publications Series

Abstract

Addendum 4 analysed ALLFROMAIR® system performance under clear-sky conditions using passive radiative cooling. A critical operational extension is fog — a phenomenon occurring several hours per day across a wide range of climates, including coastal deserts. During fog periods, the wire-forest electrode structure already present in the system functions directly as a high-efficiency fog collector, while the DEP field actively directs droplets toward the electrode surface and vibration-desorption ensures continuous drainage.

Calculations show that ALLFROMAIR® v2 achieves 0.26–0.97 L/m²/h during fog periods (Q = η × LWC_median × v × 3.6, η = 0.72), compared with 0.07–0.35 L/m²/h for …


Addendum No. 4: Radiative Hybrid Cooling, Vesa Olavi Lius Mar 2026

Addendum No. 4: Radiative Hybrid Cooling, Vesa Olavi Lius

Defensive Publications Series

Abstract

This addendum introduces a critical architectural extension of the ALLFROMAIR® system: the integration of passive radiative cooling directly into the electrode structure. Analysis of the original wire-forest configuration demonstrated that the Modified Kelvin-Thomson (MKT) effect at operational field strengths (E ≈ 1.67 MV/m) produces a vapour-pressure reduction of approximately 0.0007% — insufficient as the sole condensation driving force in sub-saturated air. The solution presented here is to supply a temperature gradient through passive infrared radiative cooling of the electrode surface, requiring no moving parts and consuming no electrical energy.

Calculations demonstrate that a SiO₂/HfO₂ selective radiative coating on an …


Existence Of Positive Periodic Solutions For A First-Order Semilinear Functional Differential Equation With An Iterative Source Term, Ahlème Bouakkaz, Rabah Khemis Mar 2026

Existence Of Positive Periodic Solutions For A First-Order Semilinear Functional Differential Equation With An Iterative Source Term, Ahlème Bouakkaz, Rabah Khemis

Turkish Journal of Mathematics

In this paper, we will establish the existence of positive periodic solutions for a class of first order iterative functional differential equations by using a powerful and effective technique based on the Krasnoselskii fixed point theorem together with some useful properties of a Green's function. The obtained results that complement some previous works, are illustrated with an example.


A Non-Newtonian Approach To Screw Motion And Dual Numbers, Esra Parlak, Zehra Özdemi̇r Mar 2026

A Non-Newtonian Approach To Screw Motion And Dual Numbers, Esra Parlak, Zehra Özdemi̇r

Turkish Journal of Mathematics

In this paper, we define multiplicative dual numbers, multiplicative dual vectors, scalars, and vector products associated with the multiplicative dual numbers. We give the base elements of multiplicative dual elliptic quaternions and their operational properties. We explain the rotation and translation motions in multiplicative dual elliptical quaternions. We provide the matrix representations of the screw motion using multiplicative dual elliptical quaternions. Thanks to these multiplicative dual elliptical quaternions, we explain the screw motion along with rotation and translation with theorems and proofs. We visualize this screw motion with mathematical programs by applying screw-ruled surfaces.


Cis-Regulatory Evolution Of Wnt Family Genes Contributes To A Morphological Difference Between Silkworm Species, Kenta Tomihara, Ana Pinharanda, Young Mi Kwon, Andrew M. Taverner, Laura S. Kors, Matthew L. Aardema, Julia C. Holder, Lin Poyraz, Takashi Kiuchi, Peter Andolfatto Mar 2026

Cis-Regulatory Evolution Of Wnt Family Genes Contributes To A Morphological Difference Between Silkworm Species, Kenta Tomihara, Ana Pinharanda, Young Mi Kwon, Andrew M. Taverner, Laura S. Kors, Matthew L. Aardema, Julia C. Holder, Lin Poyraz, Takashi Kiuchi, Peter Andolfatto

Department of Biology Faculty Scholarship and Creative Works

Closely related species often exhibit distinct morphologies that can contribute to species-specific adaptations and reproductive isolation. One example is Lepidopteran caterpillar appendages, such as the “caudal horn” of Bombycoidea moths, which have evolved substantial morphological diversity among species in this group. Using interspecific crosses, we identify the genetic basis of the caudal horn size difference between Bombyx mori and its closest relative Bombyx mandarina. The three largest of eight QTL account for one third the mean horn length difference between the species. The largest of these, on chromosome 4, encompasses a conserved Wnt family gene cluster, key upstream regulators …


Minutes, Curriculum Committee Meeting, Tuesday, March 10, 2026, Curriculum Committee Mar 2026

Minutes, Curriculum Committee Meeting, Tuesday, March 10, 2026, Curriculum Committee

Curriculum Committee Minutes

No abstract provided.


Molecular Risk Markers Define Risk Of Relapse In Myeloid Leukemia Of Down Syndrome Beyond Measurable Residual Disease., Jason N. Berman, Anupam Verma, Shelton Viola, Todd A. Alonzo, Yi-Cheng Wang, Lisa Eidenschink Brodersen, Michael Loken, Amy Beckman, Betsy Hirsch, Susana Raimondi, Karen M. Chisholm, Xiaotu Ma, Rhonda Ries, Soheil Meshinchi, Alan S. Gamis, Reuven Schore, Jeffrey W. Taub, E Anders Kolb, Todd Cooper, Johann Hitzler Mar 2026

Molecular Risk Markers Define Risk Of Relapse In Myeloid Leukemia Of Down Syndrome Beyond Measurable Residual Disease., Jason N. Berman, Anupam Verma, Shelton Viola, Todd A. Alonzo, Yi-Cheng Wang, Lisa Eidenschink Brodersen, Michael Loken, Amy Beckman, Betsy Hirsch, Susana Raimondi, Karen M. Chisholm, Xiaotu Ma, Rhonda Ries, Soheil Meshinchi, Alan S. Gamis, Reuven Schore, Jeffrey W. Taub, E Anders Kolb, Todd Cooper, Johann Hitzler

Manuscripts, Articles, Book Chapters and Other Papers

Myeloid leukemia of Down syndrome (ML-DS) is a distinct form of pediatric acute myeloid leukemia (AML) that responds to reduced-intensity chemotherapy, as compared with non-DS AML that requires intensive chemotherapy and often stem cell transplant. While most patients with ML-DS have a favorable prognosis, outcomes for those with refractory or relapsed disease are dismal. Children's Oncology Group study AAML1531 introduced the use of measurable residual disease by multiparameter flow cytometry at the end of the first course of induction therapy (EOI-1 MRD) for risk stratification of treatment intensity. Of 280 patients with ML-DS who were enrolled, 41 were classified as …


Enhancing Seventh-Grade Students’ Scientific Literacy Through The Science-Poly Game, Shita Dhiyanti, Imra’Atul Mufidah, Dyne Rizki Puspitasari, Siti Zubaidah Mar 2026

Enhancing Seventh-Grade Students’ Scientific Literacy Through The Science-Poly Game, Shita Dhiyanti, Imra’Atul Mufidah, Dyne Rizki Puspitasari, Siti Zubaidah

Journal of Innovation and Teacher Professionalism

This study aims to improve seventh-grade junior high school students’ scientific literacy through the use of the science-poly game on the topic of motion. The learning process was implemented using the lesson study approach, which consists of three stages: plan, do, and see. In the planning stage, teachers collaboratively designed learning activities and literacy-based questions integrated into the science-poly game. During the implementation stage, students participated in the game while engaging with scientific problems that required them to analyze questions, identify key scientific terms, and formulate conclusions. In the reflection stage, teachers discussed the learning outcomes and evaluated the effectiveness …


Evaluating Eastern Wild Turkey (Meleagris Gallopavo Silvestris) Behavioral Ecology In The Southeastern United States, Chad Argabright Mar 2026

Evaluating Eastern Wild Turkey (Meleagris Gallopavo Silvestris) Behavioral Ecology In The Southeastern United States, Chad Argabright

LSU Doctoral Dissertations

The wild turkey (Meleagris gallopavo spp.) is a game bird species in North America who are one of the great success stories in restoration and conservation. Wild turkeys were extirpated from most of their range in the early 20th century, but through habitat restoration and translocation efforts the population was restored to the point of being sustainably harvested in 49 U.S. States by the late 20th century. However recent declines in wild turkey population indices have necessitated ongoing research on the behavioral ecology of wild turkeys to help counteract these declines. East Texas specifically for the past century has …


On The Spot: "What Is Your Opinion On The Campus Carry Bill?", Tess Kujawa Mar 2026

On The Spot: "What Is Your Opinion On The Campus Carry Bill?", Tess Kujawa

Digital Edition

No abstract provided.


Potency-Related Effects Of Smoked Cannabis On Simulated Driving Performance: A Randomized, Controlled Crossover Trial, Bruna Brands, Adam Zaweel, Madison Wright, Patricia Di Ciano, Christine M. Wickens, Justin Matheson, Andrew Fares, Omer S. M. Hasan, Marcos Sanches, Beth Sproule, Marilyn A. Huestis, Timothy L. Brown, Bernard Le Foll Mar 2026

Potency-Related Effects Of Smoked Cannabis On Simulated Driving Performance: A Randomized, Controlled Crossover Trial, Bruna Brands, Adam Zaweel, Madison Wright, Patricia Di Ciano, Christine M. Wickens, Justin Matheson, Andrew Fares, Omer S. M. Hasan, Marcos Sanches, Beth Sproule, Marilyn A. Huestis, Timothy L. Brown, Bernard Le Foll

Institute of Emerging Health Professions Faculty Papers

Given the increasing availability of high-potency Δ9-tetrahydrocannabinol (Δ9-THC) products, understanding potency-related effects of Δ9-THC on driving performance is an important public safety issue. This randomized, double-blind, placebo-controlled, within-subjects trial examined the effects of smoked cannabis with varying Δ9-THC concentrations on simulated driving. Adults aged 19–45 who regularly used cannabis and held valid driver’s licenses completed simulated driving tasks after smoking placebo, or cannabis containing low (6.25%/47 mg Δ9-THC), medium (12.5%/94 mg Δ9-THC), or high (22%/165 mg Δ9-THC) Δ9-THC levels. The primary outcome was mean speed (km/h); secondary measures included maximum speed, standard deviation of lateral position (SDLP), reaction time (RT), …


Transnational Private Environmental Regulation: Are States Striking Back?, Errol E. Meidinger Mar 2026

Transnational Private Environmental Regulation: Are States Striking Back?, Errol E. Meidinger

Contributions to Books

Published as Chapter 11 in Research Handbook on Environmental Regulation, David Williamson, Gary Lynch-Wood & Agne Prochorskaite, eds.

Rapid global trade expansion beginning in the 1990s spawned a parallel expansion in non-state (‘private’) environmental regulatory (PER) programs. They issue regulatory standards, monitor and judge performance, sanction poor performance, and sometimes regulate state activities. PER programs constitute extensive and complex transnational governance agglomerations encompassing environmental certification, corporate social responsibility, and environment-society-governance programs, typically intertwined with governmental and intergovernmental regulatory programs.

Using forestry and climate change examples, this article analyzes key features of PER programs, how they may be growing empirically more …


Moderate-Temperature Hydrothermal Treatment Removes Detectable Dna And Antibiotic Resistance Genes From Municipal Sludge While Preserving Resource Value, R Sean Norman M.Sc., Ph.D., Mirza Isanovic, Gabrielle Kartzmark, Nicole Berge Mar 2026

Moderate-Temperature Hydrothermal Treatment Removes Detectable Dna And Antibiotic Resistance Genes From Municipal Sludge While Preserving Resource Value, R Sean Norman M.Sc., Ph.D., Mirza Isanovic, Gabrielle Kartzmark, Nicole Berge

Faculty Publications

Wastewater treatment plants (WWTPs) are key reservoirs of antibiotic resistance genes (ARGs), with municipal sludge containing high bacterial densities and diverse ARGs that may spread through land application. Hydrothermal treatment (HT) is a process that inactivates pathogens and stabilizes biomass, but its performance at moderate temperatures is less understood. We evaluated HT (100°C–250°C; 2–24 h) for degrading bacterial DNA and ARGs in dewatered municipal sludge. DNA was quantified by fluorometry, bacterial presence confirmed by 16S rRNA gene PCR, and ARGs profiled by qPCR targeting 84 clinically and environmentally relevant genes. HT up to 250°C produced modest carbon densification, high solids …


Moderate-Temperature Hydrothermal Treatment Removes Detectable Dna And Antibiotic Resistance Genes From Municipal Sludge While Preserving Resource Value, R. Sean Norman, Mirza Isanovic, Gabrielle Kartzmark, Nicole Berge Mar 2026

Moderate-Temperature Hydrothermal Treatment Removes Detectable Dna And Antibiotic Resistance Genes From Municipal Sludge While Preserving Resource Value, R. Sean Norman, Mirza Isanovic, Gabrielle Kartzmark, Nicole Berge

Faculty Publications

Wastewater treatment plants (WWTPs) are key reservoirs of antibiotic resistance genes (ARGs), with municipal sludge containing high bacterial densities and diverse ARGs that may spread through land application. Hydrothermal treatment (HT) is a process that inactivates pathogens and stabilizes biomass, but its performance at moderate temperatures is less understood. We evaluated HT (100°C–250°C; 2–24 h) for degrading bacterial DNA and ARGs in dewatered municipal sludge. DNA was quantified by fluorometry, bacterial presence confirmed by 16S rRNA gene PCR, and ARGs profiled by qPCR targeting 84 clinically and environmentally relevant genes. HT up to 250°C produced modest carbon densification, high solids …


The Association Of P27 With Prostate Cancer Outcomes: A Secondary Analysis Of Nrg/Rtog 8610 And 9202, Krishnan Patel, Stephanie Pugh, Jeffry Simko, Anthony Zietman, Michelangelo Fiorentino, David Paul D'Souza, Seth Rosenthal, Adam Currey, Adam Dicker, Bradley Stish, Eric Horwitz, Tyler Robin, Michael Dominello, Christopher Peters, Kwang Choi, Jason Efstathiou, Samir Narayan, George Daniel Grass, Zaker Rana, Phuoc Tran, Massimo Loda, Paul Nguyen Mar 2026

The Association Of P27 With Prostate Cancer Outcomes: A Secondary Analysis Of Nrg/Rtog 8610 And 9202, Krishnan Patel, Stephanie Pugh, Jeffry Simko, Anthony Zietman, Michelangelo Fiorentino, David Paul D'Souza, Seth Rosenthal, Adam Currey, Adam Dicker, Bradley Stish, Eric Horwitz, Tyler Robin, Michael Dominello, Christopher Peters, Kwang Choi, Jason Efstathiou, Samir Narayan, George Daniel Grass, Zaker Rana, Phuoc Tran, Massimo Loda, Paul Nguyen

Kimmel Cancer Center Faculty Papers

PURPOSE: The cyclin-dependent kinase inhibitor p27 is a well-profiled modulator of cell cycle progression. Low nuclear p27 levels have been demonstrated to have a negative prognostic impact on outcomes in patients undergoing prostatectomy. The prognostic value of p27 after radiation therapy (RT) for prostate cancer is unknown.

METHODS AND MATERIALS: Levels of p27 were evaluated in pre-RT prostate biopsy samples from 2 randomized, phase 3 trials, NRG/RTOG 8610 and 9202, which treated patients with RT with or without androgen deprivation therapy (ADT). Nuclear p27 was analyzed using immunohistochemistry and quantified using automated imaging analysis. The association of p27 as both …


Multiple Persistent Nodular Lesions In An Infant: Diagnosing Disseminated Juvenile Xanthogranuloma, Kourtney Kelly Mar 2026

Multiple Persistent Nodular Lesions In An Infant: Diagnosing Disseminated Juvenile Xanthogranuloma, Kourtney Kelly

Biochemistry and Molecular Biology

No abstract provided.


International Consensus-Driven Recommendations For Patient-Reported Outcome Research Objectives In Early Phase Dose-Finding Oncology Trials: Optimise-Ror, Emily Alger, Olalekan Lee Aiyegbusi, Amylou C Dueck, Anna Minchom, Madeline Pe, John D Peipert, Claire Snyder, Stefan N Symeonides, Roger Wilson, Ethan Basch, Yu Qiao, Susan E Bates, Helen Bulbeck, Lizzie Dean, Massimo Di Maio, Aaron R Hansen, Olga Kholmanskikh, Ken Kobayashi, Dónal Landers, Christophe Le Tourneau, J Jack Lee, Brigette B Y Ma, Lynley V Marshall, Sheetal Patel, Joan Petrie, Gregory R Pond, Kieran Prior, Khadija R Rantell, John F Reeve, Olga Solovyeva, Nolan A Wages, Harald A Weber, Melanie J Calvert, Christina Yap Mar 2026

International Consensus-Driven Recommendations For Patient-Reported Outcome Research Objectives In Early Phase Dose-Finding Oncology Trials: Optimise-Ror, Emily Alger, Olalekan Lee Aiyegbusi, Amylou C Dueck, Anna Minchom, Madeline Pe, John D Peipert, Claire Snyder, Stefan N Symeonides, Roger Wilson, Ethan Basch, Yu Qiao, Susan E Bates, Helen Bulbeck, Lizzie Dean, Massimo Di Maio, Aaron R Hansen, Olga Kholmanskikh, Ken Kobayashi, Dónal Landers, Christophe Le Tourneau, J Jack Lee, Brigette B Y Ma, Lynley V Marshall, Sheetal Patel, Joan Petrie, Gregory R Pond, Kieran Prior, Khadija R Rantell, John F Reeve, Olga Solovyeva, Nolan A Wages, Harald A Weber, Melanie J Calvert, Christina Yap

Faculty, Staff and Student Publications

Purpose: There is growing scientific interest in incorporating patient-reported outcomes (PROs) in early phase dose-finding oncology trials (DFOTs) to assess tolerability, inform dose selection, and guide later stage trial design. However, research indicates that PRO objectives in DFOTs are often unclear. The Incorporating Patient-Reported Outcomes in Dose-Finding Trials-Research Objectives Recommendations (OPTIMISE-ROR) project was established to support trialists to effectively incorporate PROs into DFOTs.

Methods: Using the Enhancing Quality and Transparency of Health Research (EQUATOR) Network's methodological framework, guideline development included the following: (1) a methodological review of published DFOTs incorporating PROs; (2) candidate item generation, refined through expert consultation; (3) …