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Articles 11491 - 11520 of 19082
Full-Text Articles in Entire DC Network
The Story Behind The Waves: Effects Of Urbanization And Female Presence On Waving Behavior In Fiddler Crabs, Katelyn Hansen, Blaine Griffen
The Story Behind The Waves: Effects Of Urbanization And Female Presence On Waving Behavior In Fiddler Crabs, Katelyn Hansen, Blaine Griffen
Library/Life Sciences Undergraduate Poster Competition 2026
Animal communication plays a central role in survival and reproduction, allowing individuals to convey information about their quality, territory, and reproductive statuses. Because signaling behaviors are often energetically costly and are dependent on both social contexts and habitat, they are sensitive to environmental conditions. Previous research has shown that male sand fiddler crabs (Leptuca pugilator) produce two distinct wave types: D-waves (typically directed towards other males) and up-and-down waves (typically directed toward females), and that they also reduce their waving behavior under urban stress. Urbanization introduces stressors such as habitat alteration and increased disturbances that can change the frequency and …
Discovery Of Short Antimicrobial Peptides In A Periplasmic Expression System, Joel Griffitts, Adam Dunn, Caleb Parker, Matthew Steed
Discovery Of Short Antimicrobial Peptides In A Periplasmic Expression System, Joel Griffitts, Adam Dunn, Caleb Parker, Matthew Steed
Library/Life Sciences Undergraduate Poster Competition 2026
Short Antimicrobial peptides (sAMPs) have the potential to make a significant impact in the ongoing battle against antibiotic-resistant bacteria. In this project, we aim to discover new sAMPs using a novel peptide expression system in E. coli. Using this system, we have successfully identified various sAMPs by testing both rationally designed peptides and randomized peptide libraries.
Derivation And Validation Of Age-Associated Prognostic Gene Signatures Across Breast Cancer Subtypes, John Speers, Adrienne Parsons, Elizabeth Feliciano, Sandra Mcallister, Lindsey Hale
Derivation And Validation Of Age-Associated Prognostic Gene Signatures Across Breast Cancer Subtypes, John Speers, Adrienne Parsons, Elizabeth Feliciano, Sandra Mcallister, Lindsey Hale
Library/Life Sciences Undergraduate Poster Competition 2026
Relatively little research has been done investigating the effects of linear age on breast-cancer specific mortality . The development of age-associated gene signatures may reveal interesting gene-set patterns with therapeautic potential. We hypothesize that the separation of patients into age categories will yield more predictive gene-signatures than an age-agnostic approach.
Colorful Proteins: Engineering A Palette Of Novel Chromoprotein Variants, Blake Olson, Anna Bowman, Kyler Fullmer, Joel Griffitts
Colorful Proteins: Engineering A Palette Of Novel Chromoprotein Variants, Blake Olson, Anna Bowman, Kyler Fullmer, Joel Griffitts
Library/Life Sciences Undergraduate Poster Competition 2026
2nd Place - Poster Design
- Chromoproteins (CP) are naturally occurring proteins originating from corals or other marine invertebrates that exhibit colors determined by their chromophore region.1
- CPs have applications as biosensors, teaching tools, and agar art; therefore, there is a need for a wide variety of CPs.2
- Hypothesis: Editing amino acid residues around the chromophore will change the chromophore’s conformation, leading to a change in color.
Cholesterol‑Containing Membranes Decrease The Helicity Of The Snare Protein Snap‑25, Christopher E. Hunt Jr., Jason T. Carlson, Michael B. Connell, Fatima D. Dagohoy, Mike Sumison, Jonathan Madsen, Chase M. Tingen, Azer E. White, Tanner M. Blocker, Dixon J. Woodbury
Cholesterol‑Containing Membranes Decrease The Helicity Of The Snare Protein Snap‑25, Christopher E. Hunt Jr., Jason T. Carlson, Michael B. Connell, Fatima D. Dagohoy, Mike Sumison, Jonathan Madsen, Chase M. Tingen, Azer E. White, Tanner M. Blocker, Dixon J. Woodbury
Library/Life Sciences Undergraduate Poster Competition 2026
Neurotransmitter release in neurons requires membrane fusion between synaptic vesicles and the presynaptic membrane. Lipids in both membranes merge through the action of SNARE proteins including SNAP-25. Changes in SNAP-25 structure or lipid composition likely modify this process. SNAP-25 has two isoforms, SNAP-25A (25A) and SNAP-25B (25B), the expression patterns of these isoforms vary throughout different brain regions and neuronal developmental stages. In vivo SNAP-25 anchors to the presynaptic membrane via attachment of palmitic acid to at least one of the four cysteines. Here we show mixing SNAP-25 (not palmitoylated) with liposomes alters both protein structure and lipid properties. Using …
C-Fms Expresses In Early Progenitor Cells & Myeloid-Lineage Leukocytes Based On Analyzing Lineage Markers And Mapping On Ly6c X Cd31 Plots In Bone Marrow, Jane Lundgren, Kelly Amsden, Evan Boesl, Victoria Hall, Emily Shakespear, Pam Van Ry, Sandra Hope
C-Fms Expresses In Early Progenitor Cells & Myeloid-Lineage Leukocytes Based On Analyzing Lineage Markers And Mapping On Ly6c X Cd31 Plots In Bone Marrow, Jane Lundgren, Kelly Amsden, Evan Boesl, Victoria Hall, Emily Shakespear, Pam Van Ry, Sandra Hope
Library/Life Sciences Undergraduate Poster Competition 2026
The Mafia mouse model expresses the green fluorescent protein (GFP) in cells that utilize the macrophage-specific c-fms promoter. The c-fms promoter controls expression of receptor for Colony Stimulating Factor 1. We hypothesize that this promotor may be utilized in bone marrow progenitor cells in addition to the mature cell expression already known in macrophage lineage cells. For this study, bone marrow cells were analyzed by flow cytometry for the expression of c-fms, early progenitor markers, and lineage-specific markers. Expression was also mapped on a Ly6CxCD31 plot, which has been used to distinguish cells based on developmental stage and lineage. This …
Cd6-Knockout Car-T Cells Display Enhanced Cytotoxicity Against Lymphoma Cell Line, Annie Larson, Alka Gaur, Nate Neyman, Collin Mickelson, K. Scott Weber
Cd6-Knockout Car-T Cells Display Enhanced Cytotoxicity Against Lymphoma Cell Line, Annie Larson, Alka Gaur, Nate Neyman, Collin Mickelson, K. Scott Weber
Library/Life Sciences Undergraduate Poster Competition 2026
Chimeric antigen receptor (CAR)-T cells are genetically engineered T cells that target surface antigens on cancer cells, showing remarkable effectiveness in treating blood cancers [1]. However, CAR-T cells are currently not effective in treating solid tumors, as the tumor microenvironment poses physical and metabolic barriers to effective CAR-T cell function. A notable strategy for increasing CAR-T cell cytotoxicity in a tumor microenvironment is knocking out or overexpressing some genes of the T cell.
Role Of Wadsley Defects And Cation Disorder To Enhance Monb12O33 Diffusion, Cj Sturgill, Manish Kumar, Nima Karimitari, Iva Millisavljevic, Coby S. Collins, Aaron Hegler, Hsin-Yun Joy Chao, Santosh Kiran Balijepalli, Scott T. Misture, Christopher Sutton, Morgan Stefik
Role Of Wadsley Defects And Cation Disorder To Enhance Monb12O33 Diffusion, Cj Sturgill, Manish Kumar, Nima Karimitari, Iva Millisavljevic, Coby S. Collins, Aaron Hegler, Hsin-Yun Joy Chao, Santosh Kiran Balijepalli, Scott T. Misture, Christopher Sutton, Morgan Stefik
Faculty Publications
Wadsley-Roth (WR) niobates have emerged as high-rate anode materials that can combine rapid ionic diffusion with good electronic conductivity. WR compounds have been defect-enhanced by limited annealing, however, such materials often contain multiple types of defects. In particular, both Wadsley defects (variable block size) and transition metal disorder have the potential to modify transport rates, however the corresponding effects are not well understood mechanistically. Here, MoNb12O33 (MNO) was calcined at two different temperatures to compare a defect-rich condition (MNO-800) with a proximal order-rich condition (MNO-900) as assessed through XRD, XANES, EXAFS, and STEM characterizations. Galvanostatically cycled lithium half cells of …
Rubber Dams In Sustainable Water Resource Management: A Comprehensive Review Of Applications, Benefits, And Future Directions, Layth Abdulameer, Khabeer Al-Awad, Nazira Dzhumagulova, Ahmed N. Al-Dujaili, Nurbol Tileuberdi
Rubber Dams In Sustainable Water Resource Management: A Comprehensive Review Of Applications, Benefits, And Future Directions, Layth Abdulameer, Khabeer Al-Awad, Nazira Dzhumagulova, Ahmed N. Al-Dujaili, Nurbol Tileuberdi
Warith Scientific Journal of Engineering and Technology
Water scarcity and flooding are serious universal problems, which are aggravated by population growth, urbanization, and climate change, and which today impact over 2 billion people with a loss of economic value of about 100 billion dollars in 2020 alone. As inflatable hydraulic constructions constructed using reinforced materials, rubber dams have become an effective technology in controlling water flow and storage within rivers, lakes, and reservoirs. The analysis demonstrates that the proportion of the current literature in the analysis is that 76% of the literature is general design and that only 24% consider any case study, with a large percentage …
A Livelihood Intervention Improved Nutritional, Mental Health And Sexual Health Outcomes Among Hiv-Affected Adolescents In Western Kenya: Results From The Shamba Maisha Randomised Controlled Trial, Sheri D. Weiser, Lila Aziz Sheira, Pauline Wekesa, Jennifer Monroe Zakaras, Edward A. Frongillo Jr. Ph.D., Elly Weke, Jason M. Nagata, Amy A. Conroy, Marguerita Lightfoot, Torsten B. Neilands, Lisa M. Butler, Elizabeth A. Bukusi, Craig R. Cohen, Maricianah Atieno Onono
A Livelihood Intervention Improved Nutritional, Mental Health And Sexual Health Outcomes Among Hiv-Affected Adolescents In Western Kenya: Results From The Shamba Maisha Randomised Controlled Trial, Sheri D. Weiser, Lila Aziz Sheira, Pauline Wekesa, Jennifer Monroe Zakaras, Edward A. Frongillo Jr. Ph.D., Elly Weke, Jason M. Nagata, Amy A. Conroy, Marguerita Lightfoot, Torsten B. Neilands, Lisa M. Butler, Elizabeth A. Bukusi, Craig R. Cohen, Maricianah Atieno Onono
Faculty Publications
Introduction Interventions that address household-level factors, including food insecurity (FI) and poverty, may reduce HIV risk and improve sexual and reproductive health (SRH) among adolescent girls and young women (AGYW).
Methods This cluster randomised controlled trial in Kenya assessed AGYW living in households of adults enrolled in Shamba Maisha (SM). SM was a multisectoral agricultural livelihood intervention designed to improve HIV health. At the trial end, we used linear and logistic regressions to compare differences between the intervention and control arms in FI, and mental health among AGYW-caregiver pairs and SRH outcomes among the AGYW, accounting for clusters with robust …
“We're Human. We Are Just Human”: Experiences Of Trans And Two-Spirit Individuals In The Midwest, Gwen Avery Donner
“We're Human. We Are Just Human”: Experiences Of Trans And Two-Spirit Individuals In The Midwest, Gwen Avery Donner
Honors Thesis
In the United States today, gender can be a hot button topic, seemingly controversial and assigned as political, and within conservative regions the topic of gender becomes more taboo. Unfortunately, this view can lead to the stigmatization and discrimination of individuals who fall outside of the socially constructed gender binary. In order to explore how living in the conservative landscape of the Midwest impacts individuals who reside outside of the gender binary, 11 semi-structured, qualitative interviews with Trans and/or Two-Spirit individuals were conducted in which they were asked about their lived experiences. The findings of the interviews revolved around two …
Genome Wide Association Study (Gwas) On Different Economic Traits And Epigenetic Stability Of Sweetpotato In Louisiana, Ajay Dhungana
Genome Wide Association Study (Gwas) On Different Economic Traits And Epigenetic Stability Of Sweetpotato In Louisiana, Ajay Dhungana
LSU Doctoral Dissertations
Sweetpotato [Ipomoea batatas (L.) Lam] is a globally important food, feed, and industrial crop, yet its improvement is constrained by a complex hexaploid genome, clonal propagation, and susceptibility to multiple diseases. In Louisiana, production is threatened primarily by Fusarium oxysporum f. sp. batatas (Fusarium wilt) and Ceratocystis fimbriata (Black rot). Furthermore, the in vitro propagation methods essential for disease-free planting material and germplasm conservation can introduce epigenetic instability that undermines clonal fidelity. This dissertation integrates genome-wide association studies (GWAS), genotype by environment interaction (GEI) and DNA methylation profiling to dissect resistance mechanisms and assess epigenetic stability in Louisiana sweetpotato …
Making The Right Decisions For Adaptive Radiotherapy, Chloe C.F. Ditusa
Making The Right Decisions For Adaptive Radiotherapy, Chloe C.F. Ditusa
LSU Doctoral Dissertations
Purpose: Daily anatomical changes can invalidate the geometric, dosimetric, and biological assumptions of reference radiotherapy plans, yet quantitative evidence describing fraction-level deviations across disease sites remains limited. This work developed and evaluated a metric-based framework for daily dose assessment to characterize temporal treatment behavior and inform adaptive decision-making in Head and Neck (H&N) radiotherapy and Prostate stereotactic body radiotherapy (SBRT). Methods: A web-based Dashboard was created to compute geometric, dosimetric, and radiobiological metrics from daily dose recalculations. Calculations were first verified against a commercial treatment-planning analysis platform. Daily dose on anatomy-of-the-day was reconstructed using CBCT-based pseudo-CTs for H&N and daily …
Aberrant Recruitment Of The Striatum And Insula Is Associated With Recalling And Suppressing Fatigue- And Anger-Related Memories In People With Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Katharine Rimes, Vincent Giampietro, Trudie Chalder, Roland Zahn, Sean Fallon
Aberrant Recruitment Of The Striatum And Insula Is Associated With Recalling And Suppressing Fatigue- And Anger-Related Memories In People With Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Katharine Rimes, Vincent Giampietro, Trudie Chalder, Roland Zahn, Sean Fallon
School of Psychology
Research suggests that people with chronic fatigue syndrome tend to suppress emotions more than healthy individuals. However, whether there are also changes in the neural substrates of emotional regulation in people with chronic fatigue syndrome remain unexplored. Specifically, it is unclear whether there is a neural delineation in how fatigue and anger-related memories are recalled or supressed in people with chronic fatigue syndrome. This study investigated this hypothesis using functional magnetic resonance imaging. We compared blood oxygen level-dependent signal changes between people with chronic fatigue syndrome (N=20) and matched controls (N= 20) during a novel task that involved the recall …
Curriculum For A Two Semester Calculus Course Specializing In Life Science And Data Science, Patrick Mcclain
Curriculum For A Two Semester Calculus Course Specializing In Life Science And Data Science, Patrick Mcclain
LSU Master's Theses
Traditionally, introductory calculus has been designed for engineering and physics students, often leaving students majoring in data science or life sciences with a curriculum that lacks professional relevance and is overly reliant on problems that focus on computational fluency. This thesis proposes a two-semester sequence, called MATH 153X and MATH 154X, specifically tailored for the Louisiana State University (LSU) Dual Enrollment program and university-level data science and life sciences majors. By integrating modern computational tools—such as symbolic calculators and artificial intelligence (AI) tools—the proposed curriculum shifts the pedagogical focus from procedural symbolic manipulation toward conceptual literacy.
Through a series …
Comparison Of Sampling Methods For Estimation Of Aquatic Insect Diversity And Abundance Across Seasonal Gradients In A Southern U.S. River System, Albert Henry Gasperecz
Comparison Of Sampling Methods For Estimation Of Aquatic Insect Diversity And Abundance Across Seasonal Gradients In A Southern U.S. River System, Albert Henry Gasperecz
LSU Master's Theses
Determination of benthic macroinvertebrate assemblage composition plays a vital role in assessment and management of lotic systems throughout the U.S. However, the validity of biomonitoring programs depends on accurate and precise measures of macroinvertebrate abundance, which in turn are dependent on sampling gears and protocols. The goal of this project was to assess how gear selection influences estimates of aquatic insect abundance and diversity, and how this selection can affect biological monitoring practices. I used 4 different gears in 3 southern Mississippi streams to aquatically and terrestrially collect aquatic insects seasonally throughout 2024. I identified and recorded all genera present …
Linguistic Realization Of Marketing Strategies In Food Discourse: A Pragmatic Study On Instagram Account, Titik Sudartinah, Emi Nursanti, Regita Sekar Arrum
Linguistic Realization Of Marketing Strategies In Food Discourse: A Pragmatic Study On Instagram Account, Titik Sudartinah, Emi Nursanti, Regita Sekar Arrum
Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya
In today's digital era, speech acts are not only realized through face-to-face communication but also manifested in online interaction. One of the prominent platforms where online interaction occurs is Instagram. Nowadays, Instagram functions not only as a medium for sharing personal moments but also as a powerful business tool for promotion. This study examines (1) the types of speech acts employed in the @voilajogja culinary Instagram account and (2) how these acts manifest marketing strategies in food discourse. The study applies Searle's (1979) speech act theory and Kotler and Keller's (2021) marketing management framework within a mixed-method design. The analysis …
Music-Based Intervention For Stress And Sleep In Substance Use Recovery, Olivia A. Coleman
Music-Based Intervention For Stress And Sleep In Substance Use Recovery, Olivia A. Coleman
Undergraduate Honors Theses
Aim: Sleep difficulties and elevated stress are common among individuals recovering from substance use disorders (SUDs), often persisting long after initial detoxification. Music-based interventions offer a low-risk, nonpharmacological option that may support sleep and stress regulation. This study examined whether a Structured Music Listening Protocol (SMLP) could improve sleep quality and reduce perceived stress within a residential SUD treatment program.
Methods: Fifty eligible patients were enrolled in the Intervention Group (SMLP – Structured Music Listening Protocol) and fifty in the Control Group (Standardized Therapy) from a residential treatment center for SUDs. Both groups received standard therapy from the center. The …
Oral Health In People With Schizophrenia, Leire Urien, Ainara Arnaiz, Xabier Marichalar-Mendia, Unax Lertxundi, Jose De Leon, Agate Txurruka, Nerea Jauregizar, Teresa Morera-Herreras
Oral Health In People With Schizophrenia, Leire Urien, Ainara Arnaiz, Xabier Marichalar-Mendia, Unax Lertxundi, Jose De Leon, Agate Txurruka, Nerea Jauregizar, Teresa Morera-Herreras
Psychiatry Faculty Publications
Aim This study aimed to assess the oral health status of individuals with schizophrenia and explore its association with behavioural and pharmacological factors, with particular focus on long-term antipsychotic treatment and cumulative anticholinergic burden. Methods A total of 153 adults with schizophrenia (18–65 years) from the Mental Health Network of Bizkaia (Spain), all under antipsychotic treatment for ≥12 months, were evaluated and compared with 153 controls from the general population. Data on socio-demographic variables, tobacco use and oral hygiene habits were collected. Oral health was assessed using the Decayed, Missing and Filled Teeth (DMFT) index and the Community Periodontal Index …
Donor Sex And Platelet Storage Change The Therapeutic Effects Of Platelet-Derived Extracellular Vesicles On Endothelium, Mandeep Kaur, Malvika Gupta, Sowmya Shree Gopal, Charles E. Wade, Jessica C. Cardenas, Amit K. Srivastava
Donor Sex And Platelet Storage Change The Therapeutic Effects Of Platelet-Derived Extracellular Vesicles On Endothelium, Mandeep Kaur, Malvika Gupta, Sowmya Shree Gopal, Charles E. Wade, Jessica C. Cardenas, Amit K. Srivastava
Cardeza Foundation for Hematologic Research
Platelet-derived extracellular vesicles (PEVs) play an active role in vascular protection and repair and are being explored as a viable alternative to platelet therapy. Because platelet function and stability are shaped by donor sex and storage conditions, these same factors are likely to influence the PEVs they release. Understanding these influences is key to developing PEVs into a safe and dependable therapeutic option. In this study, we investigated how donor sex and platelet storage affect the therapeutic properties of PEVs. To address this, PEVs were isolated from platelets of healthy male and female donors. Platelets were either processed immediately after …
Decision Making Processes Of Adolescent Women About Entering Intimate, Long-Term Romantic Relationships, Jeannie Miller
Decision Making Processes Of Adolescent Women About Entering Intimate, Long-Term Romantic Relationships, Jeannie Miller
Walden Dissertations and Doctoral Studies
There is a high rate of women in their late 20s and early 30s that are in destructive relationships, many because of decisions that were made during adolescence . Little research has focused on understanding the decision making process of entering intimate, long-term romantic relationships from the viewpoint of adult women in their late 20s through 30s who made that decision during adolescence. This phenomenological study allowed for a greater understanding of adolescent decision making, specifically about entering intimate, long-term romantic relationships. The research questions were (a) What are the lived experiences of young women as they enter intimate, long-term …
Nathan Furey Appointed As The First Robert Summers Professor Of Biology, Mark Wanner
Nathan Furey Appointed As The First Robert Summers Professor Of Biology, Mark Wanner
UNH Today Archive
No abstract provided.
Psy312 - Psychology Of Memory, Sandra Campeanu
Psy312 - Psychology Of Memory, Sandra Campeanu
Open Educational Resources
Theoretical issues, established findings, empirical research, and contemporary controversies in the study of memory. Analysis of the processes of encoding, storage and retrieval, including models, developmental changes, neurophysiology, and memory distortions. Consideration of the ways memory influences behavior, problem solving, and sense of self.
This document is a revised syllabus for Professor Campeanu's PSY312 - Psychology of Memory course at Lehman College.
Government Goes Goop, Jennifer D. Oliva
Government Goes Goop, Jennifer D. Oliva
Emory Law Journal Online
This Article argues that the appointment of prominent wellness and antivaccine figures to senior federal health positions marks the culmination of a long-running evolution in American health fraud—from nineteenth-century traveling medicine shows to the institutional capture of government health agencies. Drawing a direct lineage from patent medicine marketing to contemporary wellness conspiracism, this Article demonstrates how tactics perfected by early medicine show entrepreneurs—emotional manipulation, conspiratorial framing, anti-establishment positioning, and the exploitation of information asymmetries—have persisted across regulatory and technological shifts, ultimately achieving unprecedented political legitimacy.
This Article traces this evolution through the deregulated supplement marketplace created by the Dietary Supplement …
Practice Patterns And Inpatient Outcomes In Lung Abscess: A Cross Sectional Study, Saikou Saidy, Ali Iqbal, Saqib H. Baig
Practice Patterns And Inpatient Outcomes In Lung Abscess: A Cross Sectional Study, Saikou Saidy, Ali Iqbal, Saqib H. Baig
Division of Pulmonary, Allergy, and Critical Care Medicine Faculty Papers
Background: Lung abscess is typically managed with antibiotics, but drainage procedures are sometimes performed when there is inadequate clinical response or when source control is needed. Real-world inpatient practice patterns remain incompletely described in contemporary U.S. data. Our aim was to evaluate national inpatient practice patterns, predictors of procedural intervention, and associated in-hospital outcomes and resource utilization among patients hospitalized with lung abscess managed conservatively, with bronchoscopic drainage, or with percutaneous drainage.
Methods: Using the National Inpatient Sample (NIS) (2016–2018), we identified adult (18 years and older) hospitalizations with a principal diagnosis of lung abscess [International Classification of Diseases, 10th …
Towards Understanding Robust Neural Coding Through Representational Geometry, Zeyuan Ye
Towards Understanding Robust Neural Coding Through Representational Geometry, Zeyuan Ye
Arts & Sciences Graduate Student Theses and Dissertations
Neural activity is high-dimensional and variable, yet animals represent information robustly. This thesis studies the origins of such robustness through the lens of representational geometry and deep neural network modeling. From a geometric perspective, population responses concentrate near smooth manifolds embedded in a high-dimensional state space. To infer these manifolds from noisy data and quantify their geometric properties, we develop a statistical method based on Gaussian processes and kernel regression (GKR). Applying GKR to simultaneously recorded grid-cell population activity during open-field navigation, we show that increasing running speed expands a torus-like representational manifold and improves spatial decodability. Thus, despite faster …
March 26, 2026, James Madison University
March 26, 2026, James Madison University
The Breeze, 2020-
The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.
Belowground Drivers Of White Oak (Quercus Alba L.) Artificial Regeneration: Nursery Soil Fungal Communities And Expanded Genomic Resources For U.S. Phytophthora Cinnamomi, Amira Noui
Electronic Theses and Dissertations Archive
White oak (Quercus alba L.) reforestation relies on nursery-grown seedlings, yet the microbial processes influencing seedling quality and disease risk remain poorly understood. Integrating nursery fungal community ecology with pathogen genomics is essential to evaluate belowground dynamics relevant to artificial regeneration. Using ITS2 metabarcoding of 145 soil samples from a commercial Tennessee nursery, I compared fungal communities across one-year-old fumigated (1-0), two-year-old fumigated (2-0), and two-year-old unfumigated (2-0) nursery beds. Fungal richness and community composition differed among beds. Seedling age was associated with increased ectomycorrhizal abundance and higher relative abundances of putative plant pathogens, while fumigation reduced fungal richness and …
An Integrated Germline And Somatic Genomic Model For Coronary Artery Disease, Xiong Yang, Min Seo Kim, Xinyu Zhu, Md Mesbah Uddin, Tetsushi Nakao, So Mi Jemma Cho, Satoshi Koyama, Tingfeng Xu, Laurens F Reeskamp, Rufan Zhang, Zhaoqi Liu, Yunga A, Paul S De Vries, Ramachandran S Vasan, Eric Boerwinkle, Alanna C Morrison, Bruce M Psaty, Russell P Tracy, Susan R Heckbert, Michael H Cho, Jeong H Yun, Nicholette D Palmer, Donald W Bowden, Joanne M Murabito, Daniel Levy, Nancy L Heard-Costa, George T O'Connor, Lewis C Becker, Brian G Kral, Lisa R Yanek, Laura M Raffield, Bertha Hidalgo, Jerome I Rotter, Stephen S Rich, Kent D Taylor, Wendy S Post, Charles Kooperberg, Alexander P Reiner, Braxton D Mitchell, Sharon L R Kardia, Jennifer A Smith, Patricia A Peyser, Lawrence F Bielak, Dong Keon Yon, Hong-Hee Won, Donna K Arnett, Albert V Smith, Stacey B Gabriel, Patrick T Ellinor, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium, Pradeep Natarajan, Minxian Wang, Akl C Fahed
An Integrated Germline And Somatic Genomic Model For Coronary Artery Disease, Xiong Yang, Min Seo Kim, Xinyu Zhu, Md Mesbah Uddin, Tetsushi Nakao, So Mi Jemma Cho, Satoshi Koyama, Tingfeng Xu, Laurens F Reeskamp, Rufan Zhang, Zhaoqi Liu, Yunga A, Paul S De Vries, Ramachandran S Vasan, Eric Boerwinkle, Alanna C Morrison, Bruce M Psaty, Russell P Tracy, Susan R Heckbert, Michael H Cho, Jeong H Yun, Nicholette D Palmer, Donald W Bowden, Joanne M Murabito, Daniel Levy, Nancy L Heard-Costa, George T O'Connor, Lewis C Becker, Brian G Kral, Lisa R Yanek, Laura M Raffield, Bertha Hidalgo, Jerome I Rotter, Stephen S Rich, Kent D Taylor, Wendy S Post, Charles Kooperberg, Alexander P Reiner, Braxton D Mitchell, Sharon L R Kardia, Jennifer A Smith, Patricia A Peyser, Lawrence F Bielak, Dong Keon Yon, Hong-Hee Won, Donna K Arnett, Albert V Smith, Stacey B Gabriel, Patrick T Ellinor, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium, Pradeep Natarajan, Minxian Wang, Akl C Fahed
Faculty, Staff and Student Publications
Multiple germline and somatic genomic factors are associated with risk of coronary artery disease, but there is no single measure of risk that integrates all information from a DNA sample. To address this gap, we develop an integrated genomic model that includes six germline and somatic genetic drivers for coronary artery disease, including polygenic risk score, genetically-proxied proteomic/metabolomic risk scores, and clonal hematopoiesis of indeterminate potential. We evaluated its predictive power in the UK Biobank (N = 391,536), and validate it using data from the TOPMed program (N = 34,177). The 10-year coronary artery disease risk based on the integrated …