Digital Commons Network^™

Discovering Drug-Like Compounds By Targeting Protein-Protein Interactions Using A Yeast-3-Hybrid System, Chesley C. Blake

Senior Theses

Protein-protein interactions are important targets in cancer biology as they can make historically “undruggable” proteins viable drug targets. However, the current approach to targeting protein-protein interactions relies on the use of small molecule drugs, which have low efficiencies as they must cover a large surface area of the interaction. Further, traditional drug therapies often lead to off-target toxicity, limiting therapeutic specificity. The objective of this project is to develop a selection system in yeast to identify short peptide sequences that can disrupt protein-protein interactions specific to cancer cells. Following proof of principle and development of the AH109 yeast strain having …

Evaluating The Impact Of Social Determinants Of Health On Outcomes Of Type Ii Diabetes In South Carolina, Alexander G. Downs

Senior Theses

Type II diabetes mellitus (T2DM) represents a significant public health burden in South Carolina, where 13.5% of adults are affected, surpassing the national rate of 12%. This integrative literature review examines the social determinants of health most strongly associated with T2DM morbidity and mortality in South Carolina, including race and ethnicity, socioeconomic status, rural or urban residence, educational attainment, healthcare access, and food insecurity. Evidence drawn from peer-reviewed studies, epidemiological reports, and state health data reveals that African American, rural, and low-income populations bear a disproportionate share of the diabetes burden in the state. These disparities arise through multilevel mechanisms …

Performing Politics: Contextual Shifts In Identity Expression Amongst Ingroup And Neutral Settings, Elsa Geriane Johnson

Senior Theses

Increased political divisiveness and the rise of social media have contributed to a widening gap between individuals situated on the political left and right. However, prior research has not determined whether individuals express their political identities similarly when among in-group members versus in more neutral spaces.

Individuals were observed in politically charged settings and in politically neutral settings to determine how the expression of political identities differs when among in-group members versus when discussing politics in classrooms. Data was analyzed using a systemic thematic process through the lens of social identity theory. Findings supported the hypothesis that political identities are …

Crystallization And Utility Of Brominated Phenylethynylene Bis-Urea Macrocycles, Paras Srivastava

Senior Theses

Macrocycles are large, cyclic molecules with central cavities that can encapsulate other molecules and that have uses in supramolecular chemistry. The Shimizu group has previously synthesized Macrocycle 1, a phenylethynylene bis-urea macrocycle that crystallizes in a columnar form, enabling its utility as a host in host-guest systems. Reactions within these systems can be used to modify stereospecificity, kinetics, and other physical properties. Previously, photodimerization reactions between coumarins and chromones have been studied in systems of Macrocycle 1, resulting in the improved specificity of photodimerization products. Herein, we apply a dynamic covalent chemistry (DCC) strategy to synthesize Macrocycle 1 and its …

Cell-Free Mitochondrial Dna (Mtdna) Triggers Vascular Dysfunction Via Toll-Like Receptor 9 (Tlr9)-Dependent Activation Of Inflammasomes, Mohin Amin

Senior Theses

Hypertension is the leading global risk factor for mortality and is closely associated with vascular inflammation and dysfunction. Damaged mitochondria release cell-free mitochondrial DNA (cf-mtDNA), which activates toll-like receptor 9 (TLR9). The binding of TLR9 to mtDNA activates the NLRP3 inflammasome pathway, promoting the release of pro-inflammatory cytokines via gasdermin D (GSDMD), therefore worsening inflammation. However, the mechanisms linking mitochondrial injury to inflammation-induced vascular dysfunction remain unclear. We hypothesize that cf-mtDNA triggers TLR9-dependent NLRP3 inflammasome activation contributing to vascular and endothelial dysfunction. To assess that, adult male C57BL/6 were exposed to 28 consecutive days of chronic unpredictable stress (CUS) or …

Genetic Factors In Migraine With Aura In Argentina: An Exploratory Case-Control Study, Rebeca González, Magalí Nowik, Silvina M. Miranda, Jorge A. Giglio, Diana M. Hohl, Juan A. Gili, Cecilia I. Catanesi

Human Biology Open Access Pre-Prints

Objective: Genetic characterization of migraine with aura in the population of Buenos Aires Province, Argentina.

Background: Migraine is a primary headache disorder with neurovascular involvement. Migraine with aura is a subtype that accounts for approximately 15–40% of all migraine cases. Several studies have shown that the global prevalence of migraine varies depending on the population studied. The population of Buenos Aires Province has an admixed genetic background. Several genetic association studies on migraine have been reported; however, most of them were conducted in cohorts of European ancestry, introducing a bias that overlooks global population diversity.

Methods: DNA …

Exploring The Impact Of Mental Health On Academic Performance And Engagement: An Interpretative Phenomenological Study Of Title I High School Upperclassmen In Northeast Alabama, Nataysia A. Holloway

Dissertations

This dissertation explores the intersection of student mental health and academic success within a Title I school context, particularly the lived experiences of students navigating mental health challenges while facing psychological, social, and educational barriers. Drawing on qualitative data, the study explores how mental health challenges influence student academic performance, engagement, and overall educational outcomes. Chapter one introduces mental health as a prevalent concern for adolescence, and chapter two examines existing research and details the methodological approach and supporting frameworks for this study. Subsequent chapters are devoted to the lived experiences of students and their perception of support and resources …

Aggressive R&D Consulting Companies Fail To Align With The Purpose Of R&D And R&E Tax Incentives., Emily Belanger

Michigan Business & Entrepreneurial Law Review

Research and development (R&D) credits and research and experimentation (R&E) tax incentives have recently experienced legislative changes and litigation related to the questionable methods deployed by R&D consulting firms. Proponents of research tax incentives tout their potential to produce positive externalities and innovation. Critics have pushed back, questioning whether research tax incentives are successfully achieving their purpose. The shifting landscape, litigation over aggressive tax claims, and debatable success of tax incentives signal a need to reassess whether research tax incentives are properly claimed in the United States. This paper proposes stronger regulation of R&D consulting firms to ensure research tax …

Program Development For Maternal Mental Health During The Transition To Motherhood, Lindsey A. Lindsley, Cassandra Nelson

Spring 2026 OTD Capstone Symposium

The transition to motherhood can be both rewarding and challenging, with many women experiencing increased vulnerability to postpartum depression (PPD). This capstone project focused on developing and implementing a six-week maternal mental health program designed to support postpartum women through education, occupational engagement, and peer connection. Grounded in the Model of Human Occupation (MOHO), the program used a hybrid format combining in-person and virtual sessions to improve accessibility. Program outcomes were evaluated using surveys, the Occupational Self Assessment (OSA), and participant feedback. Participants demonstrated increased knowledge of postpartum mental health, greater confidence in their maternal roles, and improved ability to …

Guns, Guardians, & Guilt: Analyzing Family Liability In Mass Shooting Cases, Alex Robinson

University of Baltimore Law Review

No abstract provided.

Bates College Journal Of Political Studies: Volume Iii, Issue 1, Spring 2026, Bates Initiative For Government Studies

Bates College Journal of Political Studies

No abstract provided.

Ciis Dissertation Abstracts 2024-2025, Dissertation Office

CIIS Dissertation Abstracts

This compilation of 69 dissertation abstracts reflects the exciting research completed by the 2024-2025 graduates from PhD programs in the School of Consciousness and Transformation and the Clinical Psychology Doctorate (PsyD) in the School of Professional Psychology and Health at the California Institute of Integral Studies (CIIS).

The original and impactful doctoral research presented here spans psychedelic studies and mental health; embodied approaches to healing and trauma; explorations of social justice, identity, and lived experience; ecological awareness and environmental renewal; spiritual and transpersonal transformation; and the evolving dynamics of digital life, culture, and relationships, and so much more.

Iris Melanoma: A Case Report And Review, Emily Scully Od, Breyne Middleton Od

Optometric Clinical Practice

Background: Uveal melanoma is the most common primary cancer of the eye. It can be diagnosed with fundus exam and ancillary tests. Metastasis occurs in about half of primary uveal melanoma patients and is very often fatal. The liver is the most common site of metastasis. Iris melanomas are the least common type of uveal melanoma. Choroidal and ciliary body melanoma are the most common. Iris nevi are quite common and the rate of transformation into melanoma is low but early detection is critical given the high mortality rate associated with metastasis.

Case Report: This case highlights the importance of …

Intermediates Or Intermedius? An Examination Of Lotic Sternotherus In Baldwin And Mobile Counties, Al, Peyton A. Wilson

Theses

The Southeastern United States is a biodiversity hotspot, and turtles are no exception to the rule. This is particularly true for the genus Sternotherus. Alabama is the only state home to all six species of Sternotherus, including the recently described Intermediate Musk Turtle (Sternotherus intermedius). It was thought that the Perdido River was the western boundary of Sternotherus intermedius; however, surveys in recent years produced questionable individuals in several small watersheds feeding into the Mobile-Tensaw Delta, bringing the species true range into question, as well as the question of if this species has hybridized with its congener, …

Fish Community Composition Across Marine Habitats Around St. Croix, U.S. Virgin Islands, Assessed Using Underwater Video, Maya L. Seesholtz

Theses

Coral reef ecosystems support highly diverse fish assemblages that are strongly influenced by habitat structure and environmental conditions. Understanding how fish communities vary across habitat types is critical for effective monitoring and management. This study evaluated habitat-associated patterns in reef fish assemblages around St. Croix, U.S. Virgin Islands, using stationary underwater video data collected through the Southeast Area Monitoring and Assessment Program (SEAMAP) Caribbean.

A total of 37 video deployments were analyzed across coral (n=20), macroalgae (n= 9), and sand habitats (n=7), with seagrass (n=1) included for descriptive purposes only. Fish abundance was quantified using the MinCount metric, and taxon …

Targeting Rna Polymerase I In Ewing Sarcoma Treatment, Alexis Bruce

Theses

Ewing sarcoma is a rare and aggressive pediatric bone cancer with poor survival rates in patients, as low as 30% in advanced or recurrent cases. There are limited treatment options, making molecularly targeted therapy vital to explore. Through CRISPR scans of Ewing sarcoma cell lines, ribosome biogenesis was highlighted as a potential target. As RNA polymerase I is a key component of ribosome biogenesis, the cytotoxic ability of two RNA Polymerase I inhibitors, CX-5461 and BMH-21, were used on patient-derived Ewing sarcoma cells. The efficacy of the drugs on two cell lines was determined via measuring cell viability, migration potential, …

Hidden Diversity In A Clonal Endemic: Insights Into Clematis Socialis From A Population Genetics Perspective, Joanna M. Lapoint

Theses

Clematis socialis (Kral) is a rare, federally endangered perennial species restricted to a small number of fragmented populations in Alabama and Georgia. The species exhibits extensive clonality and limited sexual recruitment, characteristics that complicate expectations regarding genetic diversity and population connectivity. Despite its conservation significance, genome-wide assessments of population structure have been lacking. We used genotyping-by-sequencing (GBS) to generate a genome-wide SNP dataset for 170 individuals sampled from six natural populations. Population structure and genetic differentiation were evaluated using Bayesian clustering, analysis of molecular variance (AMOVA), pairwise FST estimates, and network-based visualization. Analyses revealed strong genetic structuring among populations and …

Association Between Caffeine Consumption And Academic Performance In Gwu Undergraduate Students, Elden Badua, Leslie Davidson

GW Research Showcase 2021-2026

No abstract provided.

Association Between Cardiovascular Fitness And Strength Fitness Status Across Distinct Phenotypes In Exercising Women, Gianna Filippou, Jordyn Walters, Andrea Osorio, Felipe Cabello, Allie Chetta, Clara De Torres Ensenat, Karla Cordero-Ortega, Shery Kamel, Carmen P. Ortega-Santos

GW Research Showcase 2021-2026

No abstract provided.

Exploring The Impact Of Cat Nutrition On Consumer Purchases: An Examination On Feline Microbiome, Health, And Owner Responses, Cassidy Curry

Honors College Theses

The gastrointestinal (GI) microbiome plays a critical role in feline health, influencing conditions such as inflammatory bowel disease (IBD), kidney disease, and other digestive disorders. Diet is a major factor affecting microbial balance, yet many cat owners lack sufficient knowledge of feline nutrition. This may lead to suboptimal feeding practices that negatively impact microbiome stability. This study aimed to evaluate the relationship between an owner’s nutritional knowledge and their pet food purchasing decisions. Specifically, it examined feeding schedule, food type and consistency, supplement use, and veterinary engagement. A 13- question survey was administered to 84 Murray State University Honors College …

Storm-Drains As Ecosystems, Victoria E. Kennedy, Curtis Jang, Darlene Panvini

SPARK Symposium Presentations

Stormwater drains and culverts are installed across urban spaces to direct surface water and allow for proper drainage and prevent flooding and erosion. These structures and the water that they carry can provide unintended opportunities to wildlife. Previous research has shown that local ecosystems may utilize and adapt around these culverts in many ways. They can serve as habitats, connect fragmented habitats separated by roads or human traffic, serve as drinking spots, and promote biodiverse plant growth. This project aims to analyze these often-overlooked spaces as ecosystems themselves, so that we can learn more about their impact and significance.    Key …

Alfred Russel Wallace Notes 40. A Comprehensive Bibliography Of Books And Booklets About Alfred Russel Wallace, George Beccaloni, Jasper H. Pol, Charles H. Smith Editor

Faculty/Staff Personal Papers

This bibliography presents the most comprehensive listing to date of books and booklets on Alfred Russel Wallace’s life and work, in all languages and editions, while excluding AI-generated works and most print-on-demand titles. It is based on a list compiled in 2023, which was expanded through searches of online catalogues and other resources. Analysis of the 160 works reveals a marked increase in publications since the late twentieth century, substantial linguistic diversity, and the growing use of manuscript sources in scholarly studies, particularly following the online availability of Wallace’s correspondence via EPSILON.

Missouri Policy Journal -Volume 2, Issue 3 (2026) -Full Issue

Missouri Policy Journal

No abstract provided.

Evaluating A Research Experience For Teachers: Benefits And Challenges For Summer Stem Professional Development, Mark T. Felts, Darcy Tessman, Emily Simpson, Mark Nanny

The Rural Educator

This focus group study examined the participant motivation for and potential impact of the Research Experience for Teachers (RET) program on rural STEM educators. Due to geographic isolation and low wages in rural areas, STEM teachers often engage in summer work, which provides practical, real-world applications of STEM principles and enhances instructional methods during the school year. By fostering university partnerships and providing summer research opportunities, RET aligns with the National Rural Research Agenda’s (NREA) priorities of enhancing community relationships and bolstering teacher preparation, recruitment, and retention. Findings indicate that participation in RET boosts teachers’ curricular skills, professional networks, and …

Cellular And Molecular Characterization Of Ube3a Function In Cic-Dux4 Sarcoma, Jesse D. Walker

Theses

CIC-DUX4 sarcoma (CDS) is a rare and extremely aggressive soft tissue sarcoma that primarily affects children and young adults. CDS is characterized by an oncogenic chromosomal translocation. Current treatments for CDS are similar to those in other sarcomas like surgery, chemotherapy, and radiation. Treatments, however show that CDS responds poorly compared to other sarcomas, due to relapses of localized disease at high rates and short duration response of treatment, proving the importance of understanding CIC-DUX4’s complex role on how it regulates overall gene expression in CDS cells from a molecular approach.

UBE3A is a ubiquitin protein ligase that plays a …

The Significance Of Vaccine Education In Vaccination Status, Emma Webb

Honors College Theses

In recent years, more of the general population of the United States has become skeptical about vaccines and overall vaccination numbers have declined. Since the Covid-19 pandemic, vaccines have become somewhat of a controversial topic due to varying opinions about the adverse reactions and effectiveness of vaccines. The purpose of this study was to determine if there is a correlation between a person’s overall knowledge of vaccinations and a person’s vaccination status by asking a series of questions about the science used in vaccines and identifying the participant’s vaccination status in regards to influenza and Covid-19. This study also asked …

Burnout Sentinel: An Early Warning System For Student Burnout Using Workload And Recovery Indicators, Minh Duy Do

Expo Student Presentations

2026 Spring Expo Video Essay Presentation

• Biological & Life Sciences
• Health Sciences & Health Professions
• Physical & Applied Sciences
• Service-Learning
• Social & Behavioral Sciences

Effect Of Missense Mutation In Pah Gene At Position 46: Glycine To Arginine, Lily Hammond, Tiffany Tran

Expo Student Presentations

2026 Spring Expo Online Poster Presentation

• Biological & Life Sciences

Hif1Α-Driven Glycolysis Controls Ifn-Γ Production And Immune Checkpoint Blockade Response In Hypoxic T Cells, Zach Lewis, Hongxing Shen, Oluwagbemiga A. Ojo, Vivian Y. Shi, Haitao Ding, Abdelrahman Yassin, James A. Bonner, Lewis Zhichang Shi

Expo Student Presentations

2026 Spring Expo Poster Presentation

• Biological & Life Sciences

Sex Specific Effects Of Early Life Stress On Blood Pressure Regulation Is Independent Of Arterial Stiffness In Rats, Vanvy Ly, Hiruni M. Aponso, David M. Pollack

Expo Student Presentations

2026 Spring Expo Poster Presentation

• Biological & Life Sciences