Digital Commons Network^™

Cross-Gender Teaching Dynamics In Single-Gender Schools: A Case Study On School Leaders’ Perspectives On Gendered Teaching Practices, Support, And School Culture, Kelsie R. Copeman

Doctoral Dissertations and Projects

The purpose of this comparative case study is to examine the gendered experiences of teachers through the perspective of school leaders at single-gender schools. The theory guiding this study is Tomlinson’s theory on differentiated instruction, as it explains how the recognition and response to student differences allows for effective teaching in order to optimize learning experiences. The central research question is: How do school leaders perceive and navigate cross-gender teaching dynamics in single-gender schools? This study uses semi-structured interviews, focus groups, and journal entries from school leaders. The sample consists of 10 school leaders with current experience in single-gender schools, …

Biting Hurts: A Transcendental Phenomenological Study Of Childcare Stakeholders’ Experience When Toddlers Bite In North Texas, Sarah Elizabeth Borszich

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to describe the lived experiences of participating in decision-making responses following biting incidents for key childcare stakeholders at licensed childcare centers in Northeast Texas. At this stage in the research, lived experiences of participating in decision-making responses following biting incidents were generally defined as integrated processes, perceptions, or actions taken by childcare stakeholders when engaging in decision-making after a biting incident in a childcare setting. The theories guiding this study were social cognitive theory (Bandura, 1986) and sociocultural theory (Vygotsky, 1978). The central research question was: What are the lived experiences of …

The Lived Experiences Of Special Education Teachers’ Longevity In Their Field: A Hermeneutic Phenomenological Study, Terri Michele Blauvelt

Doctoral Dissertations and Projects

The purpose of this qualitative, hermeneutic phenomenological study was to understand factors that influenced the motivation of special education teachers toward longevity in public K-12 schools located in the United States. This study attempted to answer the following research question: What do special education teachers perceive motivational factors toward longevity in a K-12 public school? The theory that guided this study was Deci and Ryan’s self-determination theory as it relates to what motivated teachers to continue to teach long-term in K-12 public schools. A total of 11 special education teachers with ten or more years of experience participated in individual …

A Transcendental Phenomenological Study On The Ethical Use Of Artificial Intelligence In Instructional Practice, Jan David Bagwell

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to understand the instruction of the ethical use of artificial intelligence through the lived experiences for teachers at Little Texas High School, North Carolina. The theory guiding this study was Mishra and Koehler’s technological pedagogical content knowledge theory, which explains how teachers can use their knowledge of content, pedagogical practices, and technology to integrate the three skill sets to best instruct their students. This framework aligns with the ethical use of artificial intelligence because it recognizes artificial intelligence as a technological tool that can be used with a teacher’s content knowledge to …

A Study Of The Lived Experiences And Identity Of Sexual And Gender Minority Young Adults, Hillary T. Coolbaugh

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to describe the lived experiences of sexual and/or gender minority young adults with autism spectrum disorder traits and borderline personality disorder features in Grand Rapids, Michigan. Guided by the Minority Stress Model, this study explored how distal and proximal stressors influence mental health, relational functioning, identity formation, and coping processes within this population. Moustakas’ modification of van Kaam’s transcendental phenomenological method guided data coding and analysis. Semi-structured interviews were conducted with participants who met the inclusion criteria. Data analysis followed established phenomenological procedures, including horizontalization and development of textural and structural descriptions …

A Transcendental Phenomenological Study Of The Lived Experiences Of Christians Who Have Experienced Divine Healing And The Role Of Relational Spirituality, Dora Hicks

Doctoral Dissertations and Projects

Divine healing has been described as miraculous and supernatural, attributed to a divine entity, and other methods. Pathways have varied from fasting, praying, worshiping, the Holy Spirit, Scripture, faith, hope, trusting, surrendering, and having a relationship with God. Perceptions and understandings of God, as influenced by religious and spiritual beliefs, are referred to as relational spirituality grounded in attachment theory, which may lead to viewing God as an attachment figure, influencing perceptions of self and others. This qualitative transcendental phenomenological study explores the lived experiences of Christians who have experienced divine healing and the role of relational spirituality. Delimitations are …

Schema Therapy For The Treatment Of Chronic Depression: A Critical Review Of Evidence-Based Treatment Methods, Trevor Ink

Doctoral Dissertations and Projects

This review explores current evidence-based interventions for the treatment of depression. Many of the current interventions display moderate to high levels of efficacy in decreasing depression severity and are praised for their effectiveness. However, many current front-line interventions fail to address the root cause of depressive symptomology. Schema therapy is an integrative treatment that targets core emotional needs that failed to be met during crucial developmental stages. Originally developed for personality disorders, schema therapy is effective for a myriad of disorders, including chronic depression. By targeting early maladaptive schemas (EMS), schema therapy can be effective for treating chronic depression when …

The Experiences Of Service-Learning From The Perspectives Of Physician Preceptors: A Phenomenological Qualitative Study, Claudia Moore

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to describe the lived experiences of supervising medical students for physician preceptors at service-learning sites in the mid-Atlantic region of the United States. The theory guiding this study was the experiential learning theory, posited by Dewey and refined by Kolb, concerning service-learning and undergraduate medical education. This study explored four research questions presented to physician preceptors to examine the barriers to implementing service-learning requirements at medical schools. These questions stemmed from the central research question: What are the lived experiences of supervising medical students for physician preceptors at a service-learning site? This research …

Parental Incarceration: The Lived Experiences Of Those Left Behind, Shatoya L. Young

Doctoral Dissertations and Projects

Incarceration in the United States is being touted as an obscure public health crisis. Approximately 47% of male incarcerated individuals and 58% of female incarcerated individuals are parents to minors. The number of children who have experienced parental incarceration at any point in their lives is believed to be more than 5 million. Incarceration negatively impacts the lives of children, especially when children lack an understanding of their parents' incarceration. There are risk factors that increase the possibility of adverse outcomes for children of incarcerated parents, and protective factors that mitigate the risk of poor outcomes. Many of the stories …

A Quantitative Analysis Of Ptsd Symptom Severity, Alcohol Use, And Resilience In American Military Veterans Using Standardised Assessment Instruments, Oladimeji Owolabi

Doctoral Dissertations and Projects

Post-Traumatic Stress Disorder (PTSD) continues to be a significant mental health concern among U.S. military veterans. This quantitative study examines the interrelationships among PTSD symptom severity, alcohol use, and psychological resilience using three standardised instruments: the PTSD Checklist for DSM-5 (PCL-5), the Alcohol Use Disorders Identification Test (AUDIT), and the Connor-Davidson Resilience Scale (CD-RISC). A cross-sectional correlational design was implemented with a convenience sample of 150 American military veterans, recruited through online platforms and veteran-focused organisations from all branches. Participants completed an anonymous online survey that assessed trauma-related symptoms, alcohol consumption behaviours, and resilience levels. Statistical analysis included descriptive statistics, …

Investigating The Effects Of Biological Sex And Academic Qualifications On Teacher Self-Efficacy Among Middle School Teachers In Ghana: A Causal Comparative Study, Enock Yeng

Doctoral Dissertations and Projects

The purpose of this quantitative, causal comparative study was to investigate the differences in teacher self-efficacy among middle school teachers in Ghana based on biological sex and academic qualifications. This study investigated the effects of biological sex (male or female) and academic qualifications (associate, bachelor’s, or master’s degree) on teacher self-efficacy among 196 middle school teachers in the Effutu Municipality (Winneba) in the central region of Ghana. The study addressed the ambiguity of how academic preparation and demographic characteristics shape a teacher's confidence to positively impact student learning. Data were collected using the teachers' sense of efficacy scale, and a …

The Perceived Influence Of Co-Curricular Support Systems On The Educational Leadership And Development Of High-School-Aged Children In Single-Parent Homes In South Florida: A Transcendental Phenomenological Study, Jonathan A. Biles

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to describe the perceptions of co-curricular support systems regarding the educational leadership and development of high-school-aged children in single-parent homes in South Florida. Focusing on the Tri-County area of South Florida, the theory guiding this research is Erik Erikson’s eight stages of psychosocial development, which pertain to the adolescent stage of development. The central research question was: What is the perception of co-curricular activities' influence on the academic achievement of adolescent-aged students raised in single-parent homes? Using multiple data collection methods: questionnaires, personal interviews, and focus groups, the data gathered was used …

Establishing The St. Paul Ame Church’S Community Youth Chaplain Ministry To Equip African American Youth To Manage Their Mental, Emotional, And Spiritual Health, Michelle A. Creer

Doctoral Dissertations and Projects

African American youth face a myriad of challenges that negatively impact their well-being. As such, this study explores the role of community youth chaplaincy interventions in helping African American youth manage their mental, emotional, and spiritual health. The study focused on training the trainers who will guide and support the young people. The training and self-application/intervention centered on building resilience, identity formation, addressing racial trauma, and nurturing spiritual growth through understanding that God created participants in His image and their identity is in Christ. Nine adult participants who are engaged in churches and activities within the African American community, contributed …

Intergenerational Apologetics: A Strategy For Careful Confidence, Thomas C. Farley

Doctoral Dissertations and Projects

There is a subtle confusion between the objectives of evangelism and apologetics, leaving Open Door Baptist Church (ODBC) seniors unknowingly ill-equipped and intimidated to defend their Christian values. The purpose of this Doctor of Ministry research was to address that intimidation by training seniors in a dedicated faith-values curriculum to become confident apologetic communicators. The intervention leveraged the process of intergenerational values-sharing while training stakeholders to develop their own faith narratives by seamlessly integrating biblical values with relevant apologetic particulars into personal stories to be shared with their grandchildren. In this environment, participants could develop a personal faith narrative that …

The Lived Experiences Of Community College Faculty Working With Students With Cross-Categorical Disabilities: A Phenomenological Study, Michelle Rosalie Amenta

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to describe the preparedness towards disability for faculty members at community colleges. The theory guiding this study was Oliver’s social model of disability, as the theory explained the relationship between environmental, institutional, and attitudinal barriers and disabilities. The central research question was: What are the lived experiences of community college faculty who instruct students that self-disclose their cross-categorical disabilities? The research sample included thirteen faculty members from community colleges in varied disciplines across the United States. Data collection consisted of individual interviews and focus groups, with analysis using Moustakas’ modified Stevick-Colaizzi-Keen Method …

A Father To The Fatherless: A Trauma-Informed Care Ministry For Fatherless Fathers, Delmus L. Gillis

Doctoral Dissertations and Projects

This DMIN action research project proposed that the Bethlehem Baptist Church (BBC) did not develop ministries that specifically addressed the persistent unbiblical endemic of fatherlessness within its congregation. The initial tragedy of fatherlessness can be transformed into the beautiful design of godly families when proper attention is given to the root cause of damaged relationships and effective means of correcting abnormalities are properly instituted in the church. Therefore, the researcher created the Trauma-Informed Care Ministry for Fatherless Fathers to guide fathers who experienced fatherlessness into a biblical model of fatherhood. When the church remains silent on important matters of faith, …

Circumstances Surrounding Officer Involved Fatal Shootings, James Corrin

Doctoral Dissertations and Projects

Over the past several years, there has been concern from mainstream media outlets, politicians, citizens, and community leaders that police officers in the United States engage in unjustified use of deadly force events within communities. This has led to violent protests across the country. Police reform and the de-funding of the police have been a crucial topic for debate and discussion. An argument has been made by some individuals that law enforcement officers involved in the fatal shootings of unarmed Black male citizens are racially motivated. The purpose of the following research is to identify if these arguments are valid. …

Sexual Scripts In Conflict: Does Religiosity Moderate The Relationship Between Pornography Use And Permissive Sexuality?, Alex D. Castaneda

Doctoral Dissertations and Projects

The sexual script acquisition, activation, and application model (3AM) posits that viewing pornography leads to the internalization of the scripts implicitly and explicitly depicted. Recent research indicates that pornography viewing is associated with more permissive sexuality. Religious individuals, especially conservative Christians, report greater distress from their pornography use, and research has investigated the role of religiosity in pornography-related outcomes. Religiosity has been shown to protect against pornography exposure and buffer against the internalization of the pornographic script. Sexual script theory posits that individuals with existing scripts that are more deeply held will be less susceptible to new, contradictory scripts. This …

Machine Learning-Based Determination Of Sex-Related Bladder Cancer Biomarkers, Joseph Pizzi

Theses

Bladder cancer exhibits sex-specific behavior, occurring more frequently in males but progressing to advanced stages more commonly in females. The activation of sex hormone receptors may explain these differences, but the exact genetic drivers remain poorly understood. Furthermore, current bladder cancer biomarkers have inconsistent sensitivities and specificities in practice, making early diagnosis a challenge. This study approaches bladder cancer biomarker discovery through machine learning techniques on gender and disease-stratified RNA-seq data. Training sets limited to differentially expressed genes were subjected to four different feature selection methods: differential gene expression analysis adjusted p-value, recursive feature elimination with support vector machine, logistic …

Ex Vivo Effect Of Apixaban On Hemostatic Biomarkers In Children With Heart Disease: A Saxophone Trial Substudy, Ghada A Aborkhees, Amy J Barr, Kevin Dietrich, Christoph Male, Zhaoqing Wang, Chen Yao, R Mark Payne, Andrew C Glatz, Paul Monagle, Kristin M Burns, Alison M Reedy, Joshua L Dyme, Peter H Schafer, Antoinette Ajavon-Hartmann, Lesley G Mitchell

2020-Current year OA Pubs

BACKGROUND: The SAXOPHONE (Safety of Apixaban on Pediatric Heart Disease on the Prevention of Embolism) trial demonstrated the safety of apixaban for thromboprophylaxis in children with heart disease. Included a priori in the trial design was an exploratory biomarker substudy to evaluate the effects of apixaban on surrogate biomarkers of efficacy, thrombin generation capacity, and hemostatic proteins. The study assessed changes in d-dimer, thrombin generation assay parameters, factor VIII, fibrinogen, protein C, and protein S in children receiving apixaban compared with standard-of-care vitamin K antagonists (VKAs) or low-molecular-weight heparin.

METHODS: SAXOPHONE participants aged >1 year (n=182) had blood samples for …

Multi-Organ Physiologic Deficits During Exercise Identify Clinical And Molecular Predisposition To Heart Failure With Preserved Ejection Fraction, Isabela Landsteiner, Lindsey K Stolze, Tess E Peterson, Andrew Perry, Phillip Lin, Quanhu Sheng, Shilin Zhao, Kaushik Amancherla, Michael Y Mi, Takenori Ikoma, Laura P Cohen, Ilya Giverts, Joseph Campain, Joao A C Lima, Wendy S Post, Kent D Taylor, Robert Gerszten, Stephen S Rich, Russell Tracy, Peter Durda, Alexis C Wood, Rajeev Malhotra, Jerome I Rotter, Clary Clish, Matthew Nayor, Eric R Gamazon, Ravi V Shah, Gregory D Lewis

Faculty, Staff and Students Publications

Background: Exercise unmasks limitations in multi-organ system reserve capacity characteristic of heart failure with preserved ejection fraction (HFpEF). However, the metabolic and genetic underpinnings of exercise deficits, and their cumulative contribution to HFpEF severity and prognosis, remain incompletely understood.

Methods: We used invasive cardiopulmonary exercise testing (iCPET), metabolite profiling, and genomics to simultaneously characterize seven exercise physiologic deficits in HFpEF patients: reduced exercise stroke volume and heart rate, steep pulmonary capillary wedge pressure/cardiac output (PCWP/CO) slope, elevated pulmonary vascular resistance, pulmonary mechanical limitation to exercise, impaired peripheral oxygen extraction, and obesity-related exaggerated metabolic cost of initiating exercise. We first mapped …

Structure-Preserving Multivariate Hypothesis Testing For Mass Spectrometry Imaging And Single-Cell Data, Keziah E Liebenberg, Erin Craig, Robert Tibshirani, Livia S Eberlin

Faculty, Staff and Students Publications

Motivation: Mass spectrometry imaging (MSI) and single-cell RNA sequencing (scRNA-seq) offer high-resolution views into tissue and cellular heterogeneity. However, conventional statistical analyses often treat sub-measurements (pixels or cells) as independent, ignoring their nested origin from individual samples. This assumption inflates the effective sample size, increases false discoveries, and undermines biological interpretation. Pixel- or cell-level averaging avoids this but sacrifices spatial or cellular resolution.

Results: We evaluated block-SAM on both simulated and real-world datasets. In DESI-MSI data from kidney, lung, and ovarian tumors, block-SAM consistently identified fewer-but more reliable-differential features compared to traditional-SAM. For example, in the kidney dataset, traditional-SAM identified …

What It Takes To Solve The Origin Of Life: An Integrated Review. Part 1–Experimental Methods And Data Repositories, Silke Asche, Carla Bautista, Celia Blanco, David Boulesteix, Alexandre Champagne-Ruel, Cole Mathis, Omer Markovitch, Zhen Peng, Avinash Vicholous Dass, Eloi Camprubi

School of Integrative Biological & Chemical Sciences Faculty Publications

The origin(s) of life (OoL), which has puzzled scientists for centuries, remains a major scientific challenge in the 21st century. Research on OoL spans many disciplines, including chemistry, physics, biology, planetary sciences, computer science, and mathematics. The sheer number of different scientific perspectives relevant to the problem has resulted in the coexistence of diverse tools, techniques, data, and software in OoL studies. This has made communication between the disciplines relevant to the OoL extremely difficult because the interpretation of data, analyses, or standards of evidence varies dramatically. Here, we hope to bridge this wide field of study by providing common …

Reference Proteins To Improve Core 1 And Core 2 Alzheimer's Disease Csf And Plasma Biomarkers, Linda Karlsson, Nicolas R Barthélemy, Kanta Horie, Suzanne E Schindler, Brian A Gordon, Cyrus A Raji, Tammie L S Benzinger, John C Morris, Randall J Bateman, Et Al.

2020-Current year OA Pubs

Concentration-based fluid biomarkers represent an informative and cost-effective way to detect and monitor Alzheimer's disease (AD) pathology. However, non-AD-related interindividual variation in biofluids can also affect biomarker concentrations. Here, we investigated whether normalization of CSF and plasma biomarkers to reference proteins, such as amyloid-β40 (Aβ40) and non-phosphorylated mid-region tau (np-tau), improves their robustness and reliability of representing AD pathology load. Using the Swedish BioFINDER-2 cohort [n = 1702, 50.7% male, mean (standard deviation) age 68.4 (12.2) years], we compared the associations between tau/Aβ-PET load and fluid biomarkers alone versus biomarkers in a ratio with a reference protein (Aβ40 or np-tau) …

Versatile Smad2 And Smad3 Epitope-Tagged Mouse Models For Genomic Profiling Of Tgfβ Signaling: Uncovering Gdf9-Smad2/3 Targets, Zian Liao, Qian Zhang, Keisuke Shimada, Kaori Nozawa, Suni Tang, Masahito Ikawa, Diana Monsivais, Martin M Matzuk

Faculty, Staff and Students Publications

Transforming growth factor β (TGFβ) signaling pathways are integral for a plethora of biological processes. SMAD2 and SMAD3 are the principal transcriptional effectors of TGFβ superfamily ligands, yet quantitative, genome-wide mapping of their DNA-associated complexes under physiological contexts has remained limited due to the lack of specific, robust models. Here, we generated two versatile epitope-tagged mouse models in which endogenous SMAD2 and SMAD3 proteins are globally tagged with hemagglutinin (HA) and podoplanin (PA) sequences, respectively, enabling high-fidelity profiling of SMAD2 and SMAD3 binding across tissues. To demonstrate the broad application of our models, we exemplified the usage of our lines …

Correction: The Formation Of Tau Pore-Like Structures Is Prevalent And Cell Specific: Possible Implications For The Disease Phenotypes, Cristian A Lasagna-Reeves, Urmi Sengupta, Diana Castillo-Carranza, Julia E Gerson, Marcos Guerrero-Munoz, Juan C Troncoso, George R Jackson, Rakez Kayed

Faculty, Staff and Students Publications

This corrects the article "The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes" in volume 2, 56.

Relative Impact Of Multidomain Lifestyle Interventions On Deficit Accumulation Frailty Over 24 Months In The U.S. Pointer Trial, Mark A Espeland, Kayloni Olson, Christy C Tangney, Darren R Gitelman, Maryjo Cleveland, Amber A Thro, Yitbarek N Demesie, Heather M Snyder, Rachel A Whitmer, Pankaja Desai, Rifat Alam, Lucia Crivelli, Thomas M Holland, Olivia Preissle, Rema Raman, Michele K York, Laura D Baker

Faculty, Staff and Students Publications

Background: Multidomain lifestyle interventions hold promise as approaches to slow aging. Deficit accumulation frailty indices (FIs) are increasingly used to capture aging processes. Frailty is highly associated with increased mortality and chronic disease risk, but the degree to which multidomain lifestyle changes impact frailty is not clear.

Methods: The U.S. Study to Protect Brain Health through Lifestyle Intervention to Reduce Risk (U.S. POINTER) was a 2-year randomized clinical trial to compare two multidomain lifestyle interventions designed to increase exercise, improve diet, and promote social and cognitive stimulating activities and health monitoring. The Structured intervention incorporated greater structure, intensity, and accountability …

Machine Learning In Architecture: A Bibliometric Analysis Approach Of Trends, Influential Authorship, And Research Gaps From 2020 To 2024, Emokpae Erebor, Damilola Adesina, Benjamin Moral, Modi Zango

Architecture and Planning Journal (APJ)

This paper presents the findings of the bibliometric analysis investigating how the current research landscape of machine learning in the discipline of architecture has evolved between 2020 and 2024. This study employs a bibliometric methodology, drawing insights from peer-reviewed journal articles from 2020 to 2024, which were sourced from databases such as Web of Science, Scopus and Science Direct. Keywords were refined using Boolean operators to identify dominant trends, key application areas and ongoing research gaps. The goal of this paper is to provide a structured knowledge base that can guide future research by highlighting emerging directions. This study serves …

An Assessment Of Biophilic Design Strategies Application In Selected Hostels In A Typical Tertiary Institution, Nigeria., Emokpae Erebor, Foluke Jegede, Pontip Nimlyat, Benjamin Moral

Architecture and Planning Journal (APJ)

Designing spaces that incorporate the principles of biophilic design enhances the buildings occupants closeness to nature while also enhancing spaces connectivity and place conditions. It has environmental, health and other important benefits not only for the environment but also for the human beings that domicile around them. Firstly, this study was carried out using quantitative data obtained from 120 female students of two selected hostel facilities in a typical private University in South-West Nigeria. Secondly, observation is in identifying the actual applications where these strategies have been applied within these hostels through photographic images. This was done by identifying different …

Reproductive Performance Of Friesian Holstein Crossbred Dairy Cattle After A Foot-And-Mouth Disease Outbreak In Lembang, Indonesia, Hanunghanindito Pamungkas, Septiyani Septiyani, Nurcholidah Solihati

Jurnal Ilmu Ternak Universitas Padjadjaran

Foot-and-mouth disease (FMD) is a highly contagious viral disease that may impair reproductive efficiency in dairy cattle. This study aimed to evaluate changes in the reproductive performance of Friesian Holstein crossbred dairy cows following an FMD outbreak at UPTD BPTSP and HPT Cikole, Lembang, West Java, Indonesia. A retrospective study was conducted using reproductive records collected from 2019 to 2023. The reproductive parameters analyzed were calving interval, service per conception, conception rate, service period, and first mating postpartum. Differences between the pre- and post-FMD periods were assessed using paired sample t-tests. The results showed significant differences in calving interval, service …