Digital Commons Network^™

Therapeutic Potential Of Hookworm Proteins In Promoting Regulatory Immune Responses To Modulate Trypanosoma Cruzi Induced Liver Inflammation And Oxidative Stress, Maria Jose Villar, Cristina Poveda, Bin Zhan, Maya Gonsoulin, Kathryn M Jones

Faculty, Staff and Students Publications

Background: Chronic Trypanosoma cruzi infection causes significant liver pathology, and current antiparasitic treatments often worsen hepatic damage. Hookworm-derived proteins have shown immunomodulatory effects in inflammatory diseases, including T. cruzi-induced myocarditis.

Objective: This study evaluates recombinant hookworm proteins AIP-1 and AIP-2 for treating liver inflammation in a murine model of chronic Chagas disease (CD).

Methods: Female BALB/c mice infected with T. cruzi were treated with AIP-1 or AIP-2 (1 mg/kg) for seven days. Controls were untreated or received aspirin (25 mg/kg) for 14 days. Liver tissues were analyzed for parasite burden (quantitative polymerase chain reaction - qPCR), histopathology (H&E, Picrosirius Red), …

Molecular Heterogeneity Of Hpv-Associated Cancers And Strategies To Overcome Treatment Resistance, Sara Rasouli, Weiyi Gong, Raegan Wood, Danyal Daneshdoust, Anam Khan, Rani Mahyoob, Chongwen Cao, Zihao Yu, Nagireddy Putluri, Gennady Shvets, Haichang Li, Bo Zhao, Xuefeng Liu, Jenny Li

Faculty, Staff and Students Publications

Human papillomavirus (HPV) is a major driver of global cancer incidence, responsible for nearly all cervical cancers and a significant proportion of oropharyngeal, anal, and other anogenital cancers. Despite the availability of effective vaccines, HPV-associated cancers persist due to persistent infection, immune evasion, and the virus's ability to integrate into the host genome, contributing to molecular heterogeneity and therapeutic resistance. Here, we summarize molecular heterogeneity and the emerging combined therapeutic strategies. High-risk HPV types, notably HPV16 and HPV18, initiate carcinogenesis through persistent infection of epithelial basal cells and through the actions of the E6 and E7 oncoproteins, which disrupt the …

The Development And Pilot Evaluation Of An Out-Of-Hospital Immersive Birthing Simulation Training Application For Paramedics And Ambulance Officers Using Virtual-Reality Technology, Michella Hill

Theses: Doctorates and Masters

Out-of-hospital births (OOHBs) are births which occur outside a hospital setting. This includes planned home births attended by midwives, or unplanned OOHBs where the intention was to birth in a hospital or maternity centre, however, occurs in an unintended location. Prehospital clinicians, inclusive of registered paramedics and volunteer ambulance officers (VAOs) infrequently attend OOHBs, as most births occur in maternity wards as anticipated. OOHBs comprises < 1% of emergency ambulance requests and requires specialised skills for prehospital clinicians to competently manage birthing and potential complications. As exposure to birthing is so rare, these specialised skills and knowledge are underutilised and subject to rapid decay. Compounding the problem, obstetrics is infrequently taught across undergraduate education, in-service training, or within individual clinician’s continuing professional development. Placements shadowing midwives are scarce due to nursing and medical students receiving priority. Previous research regarding OOHBs is limited, nonetheless suggests prehospital clinicians are underprepared to manage an OOHB, which has serious patient safety implications. The present research sought to explore prehospital clinicians’ preparedness and confidence in managing OOHBs. It also investigates whether a digital training solution such as virtual reality (VR) simulation may reduce the theory-practice gap and assist in competency retention.

Publication one provides a comprehensive methodology outline which is applied to Study One; a scoping review of prehospital clinician and birth parent experiences with OOHBs. Risk factors, complications and interventions provided by prehospital clinicians, as …

Getting Ready Right: The Impact And Influence Of The University Appointed Supervisor, Madlen Griffiths

Theses: Doctorates and Masters

Initial Teacher Education professional experience is a valued component of teacher education courses, where preservice teachers can practise applying what they have learned at university in classroom settings. Key to these experiences are supervisors, who are employed by the university and support these aspiring teachers during their professional experiences. This supervisory role is complex, underrated, under-theorised and under researched. Consequently, this research sought to address this shortfall through an investigation into the perspectives of two of the major stakeholders in these experiences: the preservice teachers and the supervisors.

Adopting a social constructivist methodology, this research examined the stakeholders’ perceptions of …

Fundamentals Of Speech, Steelman Library, David Yates

Syllabus Repository

No abstract provided.

A Method For Determining A True National Statistical Distribution Of Building Element U-Values And Its Application To A Dataset Underpinning A Building Stock Energy Model, C. Ahern, Bernard Enright, A. Griffin, B. Norton

Research Outputs: 2025-Present

The presence of default U-values in Energy Performance Certificate (EPC) databases disrupts the natural variability in measured U-value distributions. Default values, often used by assessors when empirical data is unavailable, introduce deterministic artefacts into datasets, creating artificial peaks that obscure underlying statistical patterns. This study examines the impact of these default values and identifies appropriate statistical models – Lognormal, Gamma and Normal – for measured U-values in Ireland’s national EPC dataset, comprising 463,582 dwellings. Lognormal and Gamma distributions aligned better with the central peaks, while the Normal distribution more accurately captured the tails. Although no single distribution perfectly fits the …

A Simplified Computational Fluid Dynamics Investigation Of Internal Duct As A Passive Aerodynamic Solution For Electric Trucks, Omar K. Omar, Ahmad Abu Shanab, Mohammad Tarawneh, Sara Hawarneh, Dr Hani Alkhatib

Research Outputs: 2025-Present

Aerodynamic drag is a dominant factor affecting the efficiency and driving range of electric trucks, especially at high speeds. Although previous studies have mainly focused on external drag-reduction devices, internal airflow control strategies such as integrated ducts have received limited attention. This study addresses that gap by analyzing how placing an internal duct in the truck body affects drag and power efficiency. A simplified two-dimensional computational fluid dynamics (CFD) approach was employed using ANSYS Fluent to evaluate and compare a baseline truck model and a modified configuration featuring a central internal duct. The simulations assessed the drag coefficient, drag force, …

Water-Efficient Concrete Curing Using Sap-Infused Nonwoven Blankets: Material Screening And Performance Evaluation, Feras Kafiah, Omar K. Omar, Dr Hani Alkhatib

Research Outputs: 2025-Present

Concrete curing under hot-weather exposure requires sustained surface moisture while minimizing repeated waterapplication. This study develops and evaluates a two-layer external curing blanket comprising a polyethylene (PE) top sheetand a superabsorbent polymer (SAP)-infused needle-punched nonwoven polyester layer. Ten PE sheets, three sodiumpolyacrylate SAP grades, and three nonwoven fabrics were screened sequentially according to optical transmittance, SAPmorphology and absorption behavior, fabric absorptivity, SAP-fiber integration, and qualitative seven-day surface-wetnessobservations. The selected configuration (S7 PE/SAP 3/GT-80) was then demonstrated using a 1 × 2 m2 outdoor prototypeand compared with conventional wet burlap curing. The blanket-cured concrete produced a numerical mean core strengthof 36.5 …

A Review Of Data Interoperability As A Barrier To Non-Residential Building Energy Policy: Evidence From Ireland, Ankur Mitra, Kriti Bhalla, Ciara Ahern

Research Outputs: 2025-Present

Non-residential buildings account for a significant share of energy use and greenhouse gas emissions across the EU, yet evidence-based policy development remains hindered by fragmented and non-interoperable building data systems. This study evaluates the suitability of publicly available electronic datasets for characterising Ireland’s non-residential building stock and supporting bottom-up energy modelling in the context of the recast Energy Performance of Buildings Directive (EPBD 2024/1275/EU).A systematic scoping review of national government and institutional datasets was conducted using an adapted PRISMA-ScR approach. The analysis identified the national Energy Performance Certificate database and GeoDirectory as the only datasets with sufficient scale and detail …

Modeling The Proton Irradiation Resilience Of Perovskite Solar Cells, Ming Lang Tseng, Emad A.A. Ismail, Nima Ghadiri, Fuad A. Awwad

Research Outputs: 2025-Present

This study introduces a semiclassical modeling for the impact of proton irradiation on two perovskite solar cell structures: FA_0.7Cs_0.3Pb(I_0.9Br_0.1)₃/C₆₀ and Cs_0.01MA_0.01FA_0.98PbI₃/P3HT using coupled current-continuity and rate equations linked to irradiation-induced defect-generation rate. Results reveal a strong dependence of radiation response on perovskite composition. Proton irradiation can induce both ionizing and displacement damage in perovskite solar cells leading to vacancy and defect generation. The result is increased recombination and degradation of performance parameters (reduced fill factor and efficiency) or, otherwise, annihilation of …

In Vitro Efficiency Analysis Of Different Β-Tri-Calcium Phosphate And Hydroxyapatite Doped Bacterial Cellulose-Polyvinylpyrrolidone Composite Hydrogel For Bone Tissue Repair, Probal Basu, Nabanita Saha, Radostina Alexandrova, Boika Andonova Lilova, Maya Argirova, Petr Saha

Research Outputs: 2025-Present

The study emphasizes an in-depth in vitro efficiency analysis of bacterial cellulose (BC)-polyvinylpyrrolidone (PVP) composite hydrogel scaffolds which are doped with different concentrations of β-tri-calcium phosphate (β-TCP) and hydroxyapatite (HA). The hydrogels are prepared with the natural polymer, BC, and synthetic polymer, PVP. Polyethylene glycol (PEG) is also used as an anti-cytotoxic agent and agar is used as a gelling agent. β-TCP and HA were given in the ratio (w/w): 20:80 (BC-PVP- β-TCP/HA_20:80), 40:60 (BC-PVP-β-TCP/HA_40:60), 50:50 (BC-PVP-β-TCP/HA_50:50). In vitro efficacy of the different tri-calcium phosphate (β-TCP) and hydroxyapatite BC-PVP composite hydrogel scaffolds are analyzed through comparative analysis of the cell …

Simulation Of Ion Migration In Perovskite Solar Cells At Elevated Temperature And Voltage Levels, Ali Hajjiah, Nima Ghadiri

Research Outputs: 2025-Present

A coupled modeling approach based on Sah-Noyce-Shockley theory has been developed to simulate the ion migration in perovskite solar cells under elevated temperature and bias levels. The model considers the migration of cations (MA⁺) and anions (I⁻) across the structure of a MAPbI₃ solar cell (TiO₂/Perovskite/Spiro) demonstrating how at elevated temperature and applied voltage levels, the ion can migrate with different speed and the ion concentration profiles can influence the device performance parameters. Results reveal that low-energy ions migrate rapidly toward the interfaces under forward or reverse bias, with cation concentrations reaching ∼10 …

Fluid Dynamics Of A Microfluidic Micromixer–Micropump Driven By Adjacent Micro Synthetic Jets, Delara Soltani, Tim Persoons, Sajad Alimohammadi

Research Outputs: 2025-Present

Efficient mixing at the microscale remains a significant challenge in microfluidic systems due to the dominance of laminar flow and the consequent limitation of convective transport. Synthetic jets, generated by the oscillatory motion of a diaphragm within a cavity, produce a zero net mass flux while imparting periodic momentum to the surrounding fluid, thereby enabling localised flow perturbation and vortex generation that can substantially enhance mixing and mass transfer in microchannels. In this study, a pair of adjacent micro synthetic jets (AMSJs) is positioned perpendicularly to a microchannel to investigate their potential as a novel micropump-mixer. The vectoring effect of …

Health And Environmental Consequences Of Blue Light Exposure And Mitigation Strategies: A Review, Dr Hani Alkhatib, Brian Norton

Research Outputs: 2025-Present

Blue light is a natural component of the visible spectrum that has a fundamental role in regulating circadian rhythms, visual performance, mood, and daytime alertness. In modern environments, however, exposure patterns have shifted due to widespread use of artificial lighting and digital devices. Artificial blue light exposure can be mistimed relative to the biological night. This literature review examines the consequences of inappropriately timed artificial blue light exposure. Specifically, the review covers: (i) the spectral biology of blue light and its role in circadian entrainment; (ii) the timing-, intensity-, and duration-dependent effects on human sleep, ocular health, mood, and metabolic …

Library Guide Assessment Standards For Quality-Checked Review Workbook, Sarah H. Moukhliss, Trina Mccowan Adams

Library Faculty Presentations & Publications

This OER workbook introduces the Library Guide Assessment Standards (LGAS), a practical, rubric-based framework for evaluating and improving LibGuides. Adapted from established online course quality models, LGAS provides a shared language for reviewing guide design, accessibility, usability, and maintenance. Designed for both individuals and teams, this workbook offers adaptable tools that support consistent, sustainable assessment in academic library contexts.

Converging Demands, Diverging Experiences: Gendered Leadership In The Australian Mining, Oil And Gas Sector During A Prolonged Crisis, Michael Mayom Ajith, Andrei Alexander Lux, Michelle Striepe, Tim Bentley

Research outputs 2022 to 2026

Purpose: Effective leadership during a prolonged crisis requires significant emotional and moral labour. Prior literature has examined gendered differences in leadership behaviour and performance during a crisis, yet less is known about how leaders experience gendered expectations during a prolonged crisis. This study therefore examines gender differences in middle-level leaders’ experiences during a protracted crisis in the Australian extractive industry.

Design/methodology/approach: The authors used a sequential qualitative design. Semi-structured interviews were conducted with 32 middle-level leaders in the Australian mining, oil and gas industry. The full data set was first analysed thematically to establish a broad account of leadership experiences. …

On The Surface: The Mural Of Shireen Abu Akleh As Space For Encounter, Saja Abd El Hai

Dissertations and Theses @ UNI

This thesis examines a mural of Palestinian journalist Shireen Abu Akleh in the city of Baqa al-Gharbiya as a site of political encounter. Rather than approaching the mural solely as a commemorative image, the study analyzes how it generated a series of interactions through acts of creation, defacement, restoration, performance, and digital circulation. Drawing on scholarship in visual culture, graffiti studies, and political theory, I argue that the mural operates as a gendered space of political encounter through which grief, resistance, and national identity are negotiated in public space. Methodologically, the project combines visual and contextual analysis with rhetorical criticism, …

Two Cheers For Cox V. Sony, James Gibson

Law Faculty Publications

There’s a lot to dislike about the Supreme Court’s opinion in Cox Communications, Inc. v. Sony Music Entertainment. It mischaracterizes, oversimplifies, and ignores precedent. It fails to engage with important arguments. It mangles the meaning of “intent.” And it introduces uncertainty into the workings of secondary liability across other intellectual property regimes.

For these reasons, the decision doesn’t deserve three cheers. But it deserves two. Because in two important ways, the Supreme Court has succeeded. First, the opinion fixes some misguided appellate court holdings by articulating a relatively workable standard for future copyright cases involving secondary liability. Second, despite …

Lethal Injection Then And Now: A Topsy-Turvy Moment For The Abolition Movement, Corinna Barrett Lain

Law Faculty Publications

At first glance, how states execute prisoners is an entirely unattractive question for those who think that states shouldnot be executing prisoners at all. Indeed, one might reasonably take the position that discussions about how states execute presume that executions can be carried out in ways that are acceptable and unacceptable, which is antitheticalto the very core of the abolitionist position. As the renowned Henry Schwarzschild-longtime director of the ACLU's Capital Punishment Project and founder of the National Coalition to Abolish the Death Penalty-wrote in 1980, "Theworst sin of all is to do well that which should not be done …

Dismantling The Whiteness Of Legal Education, Doron Samuel-Siegel

Law Faculty Publications

Whiteness is not merely a racial description. Whiteness operates as allegiance to structural racism. The quiet engine of racial hierarchy, whiteness pervades and shapes traditional legal education, rendering legal pedagogy a structurally racist enterprise. Legal education not only reproduces the racism embedded in the law and legal profession, but also obscures the ways legal doctrine, professional norms, and pedagogical practices normalize, protect, and make invisible the advantages that accrue to whiteness itself. In doing so, itproduces lawyers ill-equipped to dismantle structural injustice.

This Article breaks new ground in the scholarship on legal pedagogy by defining whiteness as it operates within …

Masculine Devotion And Moral Decay: The Paradox Of Chivalry In Malory's Le Morte Darthur, Julia Annunziato

Graduate Studies Theses and Dissertations 2026

This thesis investigates how, within Sir Thomas Malory’s Le Morte Darthur, the concept of chivalry as a literary construct is misunderstood and misrepresented by the knights who attempt to uphold it. Through a close reading of Le Morte, this paper concludes that Malory presents chivalry not as a coherent moral code, but as a paradoxical system that both promotes and undermines the values it claims to uphold. While chivalry is typically meant to emphasize honor, loyalty, and spiritual devotion, Malory’s narrative reveals how these ideals are compromised by structures of masculine competition, performative identity, homosocial desire, and corrupted …

Lucha Libre: Legends Of The Mask, Anthony J. Aguilar

Graduate Studies Theses and Dissertations 2026

Lucha libre, also known as Mexican wrestling, is a cultural phenomenon whose history dates to 1933. Every wrestling match pits flamboyantly costumed and masked wrestlers (luchadores), classified as either the good guys (técnicos) or the bad guys (rudos), against each other in choreographed and dramatized battles. Although lucha libre is often seen as campy or “low brow” due to its exaggerated, theatrical style, this perception overlooks the deeper cultural significance and narrative potential inherent in the form. This thesis will explore the cultural evolution of lucha libre as a highly interactive themed ride attraction. By integrating guest participation through custom …

Enhancing The Immersive Experience Through The Diversification Of Operational Costuming, Emma Nevitt

Graduate Studies Theses and Dissertations 2026

This thesis will be a comparative creative project that analyzes current operational wardrobe options within immersive lands, utilizing case studies and applied research, a neutral proposed immersive land will be created with operational costuming options that provides variety to the operational wardrobe that will enhance the immersive guest experience by creating a more compelling environment through wardrobe diversity. This will be achieved through a kit-of-parts approach where staffing will have a small variety of tops, bottoms, headwear, outerwear, and accessories to create a unique look to their own wardrobe while providing narrative insight. Each piece will be designed specifically for …

Un Lugar A Donde No Puedo Volver: Perteneciendo En La Distancia, Alberto J. Alonso

Graduate Studies Theses and Dissertations 2026

“A Place I Cannot Return To: Distance and Belonging” investigates how home is not limited to a fixed place, but instead a reconstruction sustained through memory and longing, which focuses on personal experiences of being away from Puerto Rico. I contribute to this broader dialogue by offering a deeply personal perspective shaped by the complexities of cultural belonging. Through photography, collage, and painting, my art practice reconstructs fragmented visual narratives of lived experience to explore homesickness, nostalgia, and displacement, examining how personal and shared histories become anchors to what continually slips away. Although I can physically return to Puerto Rico, …

Critical Analysis Of Legal Education: Faculty Perspectives Of Law School's Role In Producing Practice-Ready Graduates, Sophia M. Akel

Graduate Studies Theses and Dissertations 2026

Legal education has long been the subject of harsh, widespread criticism due to concerns about its ability to adequately prepare students for legal practice. Newer attorneys have reported feeling incapable of performing even the most basic functions of their job after graduation from law school (Merritt & Cornett, 2020). Despite this troubling reality, law schools largely continue to function as they always have (Cramton, 1981). To gain insight directly from important figures in legal academia, this study examined law faculty perceptions on legal education’s role in producing practice-ready graduates. A mixed-methods survey design incorporating both quantitative descriptive and qualitative elements …

Investigating The Association Between Polycystic Ovary Syndrome (Pcos) And Idiopathic Intracranial Hypertension (Iih): A Cross-Sectional Analysis, Savannah L. Adams

Graduate Studies Theses and Dissertations 2026

Polycystic ovary syndrome (PCOS) and idiopathic intracranial hypertension (IIH) are chronic conditions that disproportionately affect women of reproductive age and share several metabolic risk factors, including obesity, insulin resistance, and hormonal dysregulation. Despite growing clinical interest in a potential relationship between these conditions, limited research has examined awareness, knowledge, symptom presentation, and barriers to healthcare among young adult populations. The purpose of this study was to investigate awareness, knowledge, perceived healthcare barriers, and potential associations between PCOS and IIH among college-aged individuals. A cross-sectional survey was administered to students aged 18-25 at the University of Central Florida through classroom recruitment …

'But George Floyd Wasn't A Saint': A Critical Discourse Analysis Pre And Post George Floyd, Raya Berkley-Jacobs

Graduate Studies Theses and Dissertations 2026

May 25, 2020, George Floyd died at the hands of former police officer Derek Chauvin after he placed his knee on George Floyd’s neck for 8 minutes and 46 seconds. His death sparked outrage, protests, and calls for accountability, justice, and reform. This study addresses the impact of George Floyd’s death as a focusing event that created a policy window under which federal legislation was introduced as a response to his death. Drawing on Punctuated Equilibrium Theory and Social Construction Theory, the study utilizes a critical discourse analysis to test how the death of George Floyd impacted the amount and …

Exploring Governance And Government Policies Of Preparedness And Response To Flooding In Juneau, Alaska, Derreck Asiamah

Dissertations and Theses @ UNI

Flooding poses an escalating threat to human well-being, economic stability, and environmental resilience in climate-sensitive regions such as Juneau, Alaska, where the retreat of the Mendenhall Glacier has produced an actively expanding ice-dammed lake, Suicide Basin, capable of triggering an annual Glacial Lake Outburst Flood (GLOF). This thesis explores the governance and government policies shaping flood preparedness and response in Juneau, Alaska, with particular attention to GLOF risk and the August 2024 GLOF, one of the most destructive flood events in the city's history. Grounded in adaptive governance theory and political ecology, the study offers a multidimensional perspective on institutional …

Examining The Current And Potential Impacts Of Erosion, Flooding, And Permafrost Thaw On Small Businesses In The Lower Kuskokwim Basin, Alaska, Dela Yao Agbagba

Dissertations and Theses @ UNI

Climate change has intensified hazards such as flooding, erosion, and permafrost thaw in Arctic Communities, threatening small business buildings, disrupting operations, and reducing income. Small businesses are important to these communities because they provide essential goods and services and support local economic activity. Understanding their vulnerability and adaptation needs is therefore important for sustaining communities in the Lower Kuskokwim Basin, Alaska.

This study used GIS spatial analysis and content analysis as its two main methods, supported by a limited number of semi-structured interviews. A spatial database of 78 businesses across seven Alaska Native Communities was developed, and flood susceptibility was …

Holographic Sensors For The Detection Of Volatile Organic Compounds, Graceson Antony

Doctoral

Volatile organic compound (VOC) monitoring at parts-per-million (ppm) concentration levels is essential for occupational safety, indoor air quality, and regulatory compliance. Although holographic gas sensors have been widely investigated, most operate in reflection mode as qualitative visual indicators, with limited quantitative evaluation of sensing mechanisms and scarce systematic demonstrations of repeatable multi-cycle validation for VOCs at ppm concentrations. A physics-based optimisation framework for transmission-mode holographic gas sensors which can bridge this gap has remained largely undeveloped.

This thesis presents the development and optimisation of real-time transmission-mode volume phase transmission holographic grating (VPTHG) sensors for ppm-level VOC detection. A comprehensive theoretical …