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2026

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Invasion Of Microplastics Into The Reproductive Tissues Of Feral And Domestic Felines, Emma K. Quade Jan 2026

Invasion Of Microplastics Into The Reproductive Tissues Of Feral And Domestic Felines, Emma K. Quade

Honors Undergraduate Theses

Although plastics have many useful properties in modern society, once these materials are introduced into the environment, they can cause extensive damage. Following degradation into microplastics (MP), plastic particles less than 5 mm in size, these contaminants can make their way into a variety of different environments and organisms. There are many studies that have investigated the prevalence of MP in marine environments, but fewer studies have looked into terrestrial systems, and even less that have focused on contamination in companion animals. This study sought to investigate the invasion of MP into the reproductive tissues of felines, Felis catus, …


The Impact Of Delayed Versus Immediate Cord Clamping On Newborn Vitality In Vaginal Deliveries: A Literature Review, Ava Rhea Sherota Jan 2026

The Impact Of Delayed Versus Immediate Cord Clamping On Newborn Vitality In Vaginal Deliveries: A Literature Review, Ava Rhea Sherota

Honors Undergraduate Theses

Umbilical cord management at birth is a critical component of neonatal care. Historically starting in the 1950s–1960s, hospitals have utilized immediate cord clamping (ICC), the practice of clamping and cutting the umbilical cord within the first 1–30 seconds after birth, to speed up postpartum care and newborn assessments (Ceriani Cernadas et al., 2006; Ceriani Cernadas et al., 2010; McDonald et al., 2013). This approach gained popularity in the mid-20th century due to concerns about maternal bleeding, the need for rapid neonatal evaluation, and the drive for more efficient delivery room workflows (Weckert & Hancock, 2008; Mohammad et al., 2019). Before …


The Role Of Resistance Training In Managing Menopause-Related Changes, Alyson K. Strauss Jan 2026

The Role Of Resistance Training In Managing Menopause-Related Changes, Alyson K. Strauss

Honors Undergraduate Theses

Resistance training serves as a critical non-pharmacological strategy for mitigating the physiological and psychological declines associated with the menopausal transition. This natural biological phase, marked by declining estrogen levels, typically leads to accelerated bone mineral density loss, sarcopenia, metabolic regulation disturbance, and heightened mood disturbances. To evaluate the efficacy of targeted exercise interventions, a systematic review was conducted following PRISMA guidelines. From an initial pool of 60 relevant articles, 13 studies met the specific inclusion criteria, focusing on structured resistance training protocols for perimenopausal, menopausal, and postmenopausal cohorts.

The synthesis of these studies indicates that resistance training is a highly …


Oral Health Access Among Ethnic Minority Older Adults In The United States, Jasleen K. Sodhi Jan 2026

Oral Health Access Among Ethnic Minority Older Adults In The United States, Jasleen K. Sodhi

Honors Undergraduate Theses

Oral healthcare is a critical yet often overlooked component of overall health among U.S. adults. Ethnic minorities for older adults face heightened risks of poor oral health and related health conditions, while experiencing disparities in access to care. This study aimed to systematically examine and synthesize existing literature to assess the extent to which oral health disparities exist among ethnic minority older adults in the U.S. and explore the roles of socioeconomic factors on these disparities. Guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework, we conducted a systematic review of peer-reviewed articles published in English …


Rawls On The Status Of Future Citizens, Michael Moeny Jan 2026

Rawls On The Status Of Future Citizens, Michael Moeny

Honors Undergraduate Theses

John Rawls sought to articulate principles for a just democratic society. Those principles must be justified by reasons that could be accepted by all reasonable citizens, regardless of their personal philosophical, religious, or moral commitments—what Rawls refers to as public reason. Basic political concepts, such as citizenship and rights, must also be justified in terms of public reason. Rawls stipulates that citizens enter society at birth, a claim that shapes his answer to whether legal protections for the unborn are justified. I argue that Rawls was not entitled to this stipulation, since it relies on contentious commitments that cannot be …


Magnesium-Based Metal Matrix Nanocomposite Implants And Nanobubble-Based Delivery Systems: Integrated Strategies For Bone Loss Treatment With Cytocompatibility Evaluation, Lucas José Martinho Bizuti Jan 2026

Magnesium-Based Metal Matrix Nanocomposite Implants And Nanobubble-Based Delivery Systems: Integrated Strategies For Bone Loss Treatment With Cytocompatibility Evaluation, Lucas José Martinho Bizuti

Honors Undergraduate Theses

This thesis intends to investigate the development of different multimodal therapeutic strategies for combating bone loss. Most specifically, this paper will emphasize the utilization of Magnesium-Based Metal Matrix Nanocomposite Implants (MMNC) and Nanobubble-Based Delivery Systems as options for future treatment focus. The effects of biodegradable magnesium implants were evaluated for cytotoxicity and cytocompatibility via Hematoxylin and Eosin, and Masson’s Trichrome staining, as well as radiological images. The Nanobubble-Based Delivery System is being developed and optimized as a delivery system to target osteoclast activity. This paper focused on optimizing experimental parameters, which include Rotational speeds for nanobubble stimulation under microgravity conditions …


Effect Of Plant-Based Vs. Standard American Diet On Cardiovascular Parameters In College Students, Timothy J. Horanic Jan 2026

Effect Of Plant-Based Vs. Standard American Diet On Cardiovascular Parameters In College Students, Timothy J. Horanic

Honors Undergraduate Theses

This study examines how adherence to different dietary patterns—specifically a plant-based diet compared to the standard American diet—can influence physiological indicators tied to cardiovascular health, including heart rate variability (HRV), blood pressure (BP), and heart rate (HR). Among these markers, HRV is considered especially sensitive to autonomic nervous system (ANS) regulation and may offer earlier insight into physiological stress or dysfunction than HR or BP alone. Although nutritional habits are widely believed to impact heart health, few investigations have focused on how specific long-term diets affect autonomic and cardiovascular metrics in healthy, college-aged adults. This study aims to investigate if …


The Hungry Mind: Fasting, And Executive Functions In Muslim College Students Living In America, Fatima Alziyad Jan 2026

The Hungry Mind: Fasting, And Executive Functions In Muslim College Students Living In America, Fatima Alziyad

Honors Undergraduate Theses

Ramadan fasting represents a unique intersection of religious observance and academic responsibility for Muslim college students in the United States. Despite the growing Muslim student population, no U.S.-based research has examined how fasting influences executive functioning within this group. This study investigated the effects of voluntary Islamic fasting on executive functions, specifically working memory, inhibitory control, and sustained attention, using a within-subject crossover design. Muslim undergraduate and graduate students who regularly observe Sunnah fasts completed cognitive testing on one fasting day and one non-fasting day. Working memory was assessed using the 2-back task, inhibitory control using the Stroop task, and …


A Qualitative Analysis Of Youtube-Based Dietary Messaging On Type 2 Diabetes For South Asians, Sukhmani K. Dhaliwal Jan 2026

A Qualitative Analysis Of Youtube-Based Dietary Messaging On Type 2 Diabetes For South Asians, Sukhmani K. Dhaliwal

Honors Undergraduate Theses

While South Asians experience a disproportionately high risk of Type 2 Diabetes Mellitus (T2DM), culturally tailored dietary guidance remains limited within healthcare settings. As digital platforms increasingly serve as sources of health information, YouTube has grown as a prominent space for the publishing and consumption of dietary advice. This study examines how diet-related messaging about T2DM is communicated in YouTube videos directed at South Asian populations.

Using qualitative thematic analysis, 21 videos published between 2016 and 2025 by influencers with a wide reach were analyzed. Videos were selected based on relevance to South Asian audiences, focus on dietary management of …


Cardiovascular Disease Risk Profiles Among Metropolitan And Nonmetropolitan Young Adults - A Cross-Sectional Analysis Of The 2024 National Health Interview Survey (Nhis), Steven Dimitrakakis Jan 2026

Cardiovascular Disease Risk Profiles Among Metropolitan And Nonmetropolitan Young Adults - A Cross-Sectional Analysis Of The 2024 National Health Interview Survey (Nhis), Steven Dimitrakakis

Honors Undergraduate Theses

Cardiovascular disease (CVD), a group of disorders affecting the heart and blood vessels, is one of the leading causes of death worldwide, driven by genetic, lifestyle, and environmental factors. Young adults, although not a common group at risk for CVD, can face reduced health quality due to physical limitations and other environmental factors that can increase their risk for development of CVD. Depending on where young adults live, their risk of developing CVD varies. Young adults fall within the category of individuals ranging in age from 18-24 years old, the average between all ages for young adults between the research …


The Environmental Impact On The Development Of Equine Degenerative Myeloencephalopathy, Victoria C. Reynolds Jan 2026

The Environmental Impact On The Development Of Equine Degenerative Myeloencephalopathy, Victoria C. Reynolds

Honors Undergraduate Theses

The objective of this study was to examine potential associations between environmental factors and the progression of Equine Degenerative Myeloencephalopathy (EDM). While environmental contributions to neurodegenerative diseases are increasingly recognized in human patients, little is known about their role in EDM. A comprehensive literature review highlighted the lack of research in this area. Data for this study were collected by Dr. Amy Johnson at the University of Pennsylvania's New Bolton Center. The two main areas studied were a horse’s lifestyle (specifically turnout conditions) and their geographical proximity to chemicals (pesticides, airborne neurotoxins, and water contaminants). Statistical analysis revealed there was …


Mycoethics: Reverence For Life In Light Of Modern Science, Charis E. Meyers Jan 2026

Mycoethics: Reverence For Life In Light Of Modern Science, Charis E. Meyers

Honors Undergraduate Theses

There is a 21st century wave of passion surrounding fungi and mycology, and it’s becoming louder and louder. The mycoenthusiasts themselves have a uniquely inspired ethical system born out of their science, and my aim is to both formally introduce their position, including many unspoken foundations, and defend its potential. I call this position mycoethics and attempt to collect it from the scattered tidbits in mycological media. I first identify its historical precedent, then spend a length of time establishing where its sense of goodness comes from, postulating it as a utilitarian offspring of Albert Schweitzer’s reverence for life. …


Enteral Nutrition Guidelines Improve Critically Ill Patients’ Outcomes: A Quasiexperimental Study, Marwa Abdo, Sara Elsayed Hegazy Jan 2026

Enteral Nutrition Guidelines Improve Critically Ill Patients’ Outcomes: A Quasiexperimental Study, Marwa Abdo, Sara Elsayed Hegazy

Nursing

Background: Optimal nutritional support is a fundamental element of treatment for critically ill patients. Adherence to evidence-based enteral nutrition guidelines is essential to promote patient care and prevent potential complications. Objectives: To assess the effectiveness of enteral nutrition guidelines in improving critically ill patients’ outcomes. Method: A quasiexperimental study evaluated 68 critically ill patients divided into 2 groups. The intervention group received their nutrition based on the evidence-based enteral nutrition guidelines, while the control group received their nutrition based on the unit’s routine care. The study was conducted in the surgical intensive care units of Mansoura Emergency Hospital in Egypt. …


Coral Holobiont Lipidome Response To Global Change, Lauren Zane Jan 2026

Coral Holobiont Lipidome Response To Global Change, Lauren Zane

Open Access Dissertations

Climate change is fundamentally restructuring macro-scale marine ecosystem structure and function by altering microscale metabolic processes and patterns of energy allocation. Scleractinian corals, as major ecosystem engineers, play outsized roles in ecosystem structure and function. They also occupy diverse habitats that differ in temperature regimes, light environments, hydrodynamics, and other environmental conditions, exposing corals to substantial spatial variation in stress and resource availability. Their fragile nutritional symbiosis with algal endosymbionts helps them navigate these environmental variations, but are also highly sensitive to environmental stress, particularly the timing and magnitude of water temperature changes. As pressure from environmental changes increases, the …


Predicting Self-Administered Biologic Nonadherence In Medicare Fee-For-Service Beneficiaries With Inflammatory Bowel Disease Using Machine Learning Models, Christian Rhudy, Courtney Perry, Cody Bumgardner, Michael J. Wesley, David W. Fardo, Terrence Barrett, Jeffery Talbert Jan 2026

Predicting Self-Administered Biologic Nonadherence In Medicare Fee-For-Service Beneficiaries With Inflammatory Bowel Disease Using Machine Learning Models, Christian Rhudy, Courtney Perry, Cody Bumgardner, Michael J. Wesley, David W. Fardo, Terrence Barrett, Jeffery Talbert

Psychiatry Faculty Publications

BACKGROUND: Nonadherence to self-administered biologic therapies increases risk for disease flares and adverse outcomes in inflammatory bowel disease (IBD). OBJECTIVE: To use machine learning and Medicare fee-for-service claims to create models predictive of medication nonadherence. METHODS: This study included Medicare fee-for-service beneficiaries with at least 2 IBD claims separated by 30 days between 2017 and 2021 and analyzed claims data from 2021. Beneficiaries with missing data or fewer than 3 self-administered biologic dispenses (adalimumab, certolizumab, golimumab, ustekinumab) on different dates in 2021 were excluded. Beneficiary-level nonadherence was defined as a proportion of days covered less than 0.8, and dispenselevel nonadherence …


The Apathy Economy: Patents, Advertising, And Consumer Indifference, Gavin J. Milczarek-Desai, Derek E. Bambauer Jan 2026

The Apathy Economy: Patents, Advertising, And Consumer Indifference, Gavin J. Milczarek-Desai, Derek E. Bambauer

Cardozo Arts & Entertainment Law Journal

Patents function as signals as well as rights to exclude. They inform competitors, investors, employees, and consumers about the invention and its owner. How this information affects consumers is not well understood. Existing studies disagree about how advertising a product or service as patented, or patent pending, affects the price consumers will pay. This Article offers the first major empirical study of that question andfinds that consumers behave with surprising rationality: they will not pay any price premium for a patented product. A product's patent status conveys little information about whether it is superior to competing offerings. The results hold …


Enhancing Diabetes Self-Management And Nutrition Literacy In South Stockton, California, Yessenia Bejarano, Carissa Chothia, Madisyn Widmer, Angela Lim Jan 2026

Enhancing Diabetes Self-Management And Nutrition Literacy In South Stockton, California, Yessenia Bejarano, Carissa Chothia, Madisyn Widmer, Angela Lim

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

Diabetes mellitus and food insecurity contribute to poor health outcomes among underserved adults participating in the Healthy Food Rx program at the Stockton Emergency Food Bank in South Stockton, California. Limited access to culturally relevant diabetes education and ongoing self-management resources may hinder effective diabetes management among food-insecure adults. This quality improvement project evaluated a four-week culturally responsive diabetes education program consisting of weekly education sessions, hands-on blood pressure and blood glucose monitoring, and a QR code-enabled Linktree resource platform. The intervention included weekly diabetes education sessions, hands-on monitoring of blood pressure and blood glucose, and access to bilingual digital …


Scientific Kenyon: Neuroscience Edition (Full Issue) Jan 2026

Scientific Kenyon: Neuroscience Edition (Full Issue)

Scientific Kenyon: The Neuroscience Edition

No abstract provided.


Get The Fruc(Tose) Out Of My Food, Johanna Huelsman Jan 2026

Get The Fruc(Tose) Out Of My Food, Johanna Huelsman

Scientific Kenyon: The Neuroscience Edition

No abstract provided.


Exploring Pregnancy-Related Empowerment And Person-Centered Prenatal Care In Black Pregnant And Postpartum Women In Alabama, Lauren Milam Jan 2026

Exploring Pregnancy-Related Empowerment And Person-Centered Prenatal Care In Black Pregnant And Postpartum Women In Alabama, Lauren Milam

Dissertations

Black women in the United States experience disproportionately high rates of maternal morbidity and mortality and often report feeling unheard, dismissed, or excluded from decision-making during pregnancy and childbirth. Understanding how Black women experience prenatal care and how those experiences relate to empowerment during pregnancy is essential for improving care and addressing persistent inequities. This study examined the relationship between person-centered prenatal care and pregnancy-related empowerment and explored Black women’s prenatal care experiences in Alabama using a sequential Quan → QUAL mixed methods design. In the quantitative phase, relationships among person-centered prenatal care, pregnancy-related empowerment, and care-related factors were examined …


Person‑Level Health Factors Partially Mediate The Association Between Lesbian, Gay, Or Bisexual (Lgb) Identity, Allostatic Load, And Cancer Mortality In Nhanes, Justin Xavier Moore, Alisha Patel, Missy Spears, Tracy Casanova, Heidi L. Weiss, Marvin E. Langston, Keith J. Watts, Donte Boyd, Prajakta Adsul, Meredith S. Duncan, Sydney Howard Jan 2026

Person‑Level Health Factors Partially Mediate The Association Between Lesbian, Gay, Or Bisexual (Lgb) Identity, Allostatic Load, And Cancer Mortality In Nhanes, Justin Xavier Moore, Alisha Patel, Missy Spears, Tracy Casanova, Heidi L. Weiss, Marvin E. Langston, Keith J. Watts, Donte Boyd, Prajakta Adsul, Meredith S. Duncan, Sydney Howard

Markey Cancer Center Faculty Publications

Purpose: Individuals identifying as Lesbian, Gay, or Bisexual (LGB) with high allostatic load have more than double the cancer mortality risk of heterosexual individuals with high allostatic load. This study explored how person-level health factors mediate the relationship between individuals identifying as LGB with high allostatic load and subsequent risk of cancer mortality.

Methods: We conducted a retrospective analysis of 12,470 participants in the National Health and Nutrition Examination Survey (2001–2010) linked to the National Death Index through 31 December 2019. Survey-weighted Cox regression assessed associations of individuals identifying as LGB and allostatic load with cancer mortality. Person-level health factors …


Eef2k Promotes Immune Evasion In Melanoma Via Cyclin D1–Mediated Stabilization Of Pd-L1, Yijie Ren, Darby J. Ballard, Anil Kumar, Andy F. Song, Mitiksha Gupta, Xiaofang Xiong, Xingcong Ren, Jugal Kishore Das, Jin-Ming Yang, Jianxun Song Jan 2026

Eef2k Promotes Immune Evasion In Melanoma Via Cyclin D1–Mediated Stabilization Of Pd-L1, Yijie Ren, Darby J. Ballard, Anil Kumar, Andy F. Song, Mitiksha Gupta, Xiaofang Xiong, Xingcong Ren, Jugal Kishore Das, Jin-Ming Yang, Jianxun Song

Markey Cancer Center Faculty Publications

Eukaryotic elongation factor 2 kinase (eEF2K) is a stress-responsive regulator of protein synthesis implicated in melanoma progression, but its role in tumor immune evasion remains poorly defined. We investigated how eEF2K influences programmed death ligand 1 (PD-L1) expression through modulation of Cyclin D1. We analyzed gene expression and dependency datasets from The Cancer Genome Atlas and the Cancer Dependency Map. Protein–protein interactions were assessed by co-immunoprecipitation. Cyclin D1 was inhibited pharmacologically with palbociclib. Immune responses were evaluated in murine B16-OVA and human A2058 melanoma models using flow cytometry and immunohistochemistry after genetic or pharmacologic modulation of eEF2K and Cyclin D1. …


Improving Blood Pressure Control Through Lifestyle Modification In African Americans Adults With Uncontrolled Hypertension, Tasha Leonard Jan 2026

Improving Blood Pressure Control Through Lifestyle Modification In African Americans Adults With Uncontrolled Hypertension, Tasha Leonard

Doctor of Nursing Practice (DNP) Scholarly Projects

African American adults have the highest incidence of uncontrolled hypertension (HTN), leading to premature cardiovascular death in Texas and worldwide. In a South Texas cardiac clinic, over 90% of African American adults with HTN also have obesity, compared with 55% of their Caucasian counterparts. The most prevalent factor affecting this group is poor understanding of blood pressure management, which leads to nonadherence to dietary and exercise recommendations, medication regimens, and blood pressure monitoring. The objective was to determine whether lifestyle modification using a hypertensive bundle would improve blood pressure management among African American adults in the clinical setting. The initiative …


The First 1000 Days And Beyond: The Process Of Child Development, Orazio Attanasio Jan 2026

The First 1000 Days And Beyond: The Process Of Child Development, Orazio Attanasio

Cowles Foundation Discussion Papers

This paper reviews recent developments in the economics of human development, focusing on the early years of life as a critical period for shaping long-term outcomes. Early childhood development is inherently multidimensional: cognitive and socioemotional skills evolve dynamically and interact with health, nutrition, and environmental influences. Economists have contributed to this field by providing a conceptual unifying framework that highlights how key drivers of development reflect the choices of individuals operating under incentives and constraints. Within this framework, the paper emphasizes two central challenges: understanding the interactions among multiple dimensions of development and identifying causal links—particularly the effects of different …


Monopolizing The Harvest: Corporate Influence And Regulatory Gaps In Global Seed Governance, Mia Mahmudur Rahim Jan 2026

Monopolizing The Harvest: Corporate Influence And Regulatory Gaps In Global Seed Governance, Mia Mahmudur Rahim

Vanderbilt Journal of Transnational Law

No abstract provided.


Breast Milk Versus Formula Feeding In The Development Of Necrotizing Enterocolitis Among Nicu Infants: An Integrative Review, Mackenzie Jameson, Faye Li, Liudmila Ryzhova, Mia Smith Jan 2026

Breast Milk Versus Formula Feeding In The Development Of Necrotizing Enterocolitis Among Nicu Infants: An Integrative Review, Mackenzie Jameson, Faye Li, Liudmila Ryzhova, Mia Smith

Master's Projects

Introduction/Question: NEC is a serious condition characterized by the death of intestinal tissue, primarily affecting premature infants or those with low birth weight. The incidence of NEC poses a significant concern in neonatal healthcare due to its substantial mortality risk, particularly among vulnerable populations. This condition can lead to various complications, including sepsis, nutritional deficiencies, delays in growth and development, and, in severe cases, death. NEC not only impacts the health of the infant but also affects the emotional well-being and bonding experiences of parents. Despite advancements in neonatal care, the rate of NEC has increased, highlighting the need …


Strafford County 2025 Annual Report Of The Commissioners, Treasurer, Other County Officers, And The Strafford County Delegation For The Year Ending December 31, 2025, Strafford County Representatives Jan 2026

Strafford County 2025 Annual Report Of The Commissioners, Treasurer, Other County Officers, And The Strafford County Delegation For The Year Ending December 31, 2025, Strafford County Representatives

Strafford County, NH Annual Reports

This is an annual report for 2025 containing vital statistics for Strafford County in the state of New Hampshire.


U.S. Administrative Law: A Casebook (6th Ed.), Jud Mathews Jan 2026

U.S. Administrative Law: A Casebook (6th Ed.), Jud Mathews

Faculty Scholarship

The number of administrative law texts is vast. The approach of this one, now in its fifth edition, is simple. It is: (1) to focus on the richest and most canonical cases; (2) to provide more extensive extracts of them than most casebooks; and (3) to keep the notes to a bare minimum. Updated through October 2025, the book contains a number of significant decisions from recent Supreme Court terms, as well as foundational classics that many contemporary casebooks cut, and much in between.


Too Warm To Win Big? Unpacking The Backer Dynamics Behind Female Crowdfunding Success Using A Warmth And Competence Perspective, Dan Liu Jan 2026

Too Warm To Win Big? Unpacking The Backer Dynamics Behind Female Crowdfunding Success Using A Warmth And Competence Perspective, Dan Liu

Journal of International Technology and Information Management

While crowdfunding is often heralded as a democratized funding avenue that empowers women with higher success rates, this study reveals a more nuanced picture of gender dynamics. The Stereotype Content Model suggests that women are often perceived as warmer but less competent. Using a large dataset from Kickstarter, we find that female-led projects can attract more backers, likely due to warmth-driven appeal, but receive smaller average contributions, potentially due to concerns about risk linked to lower perceived competence. However, the total funding raised by female-led campaigns is comparable to that of male-led ones, showing no clear advantage or disadvantage. This …


Colorectal Cancer Screening In Saudi Arabia: Current Challenges And Future Directions, Abdulrahman A. Aljabri, Abdulrahman G. Alharbi Jan 2026

Colorectal Cancer Screening In Saudi Arabia: Current Challenges And Future Directions, Abdulrahman A. Aljabri, Abdulrahman G. Alharbi

Saudi Medical Journal

Abstract Colorectal cancer has become a major public health concern in Saudi Arabia. It is the most prevalent cancer among men and the third most prevalent among women. Although screening for people aged 45-75 is recommended by national recommendations, screening uptake is still below 10%, and less than 1% of older persons have a colonoscopy. With regional differences that vary from age-standardized rates of 3.2 per 100,000 in Jouf to 21.8 per 100,000 in Riyadh among men, approximately 29% of cases are detected at late stages. Therefore, we assessed the epidemiological, social, and health-related systemic structures preventing effective colorectal cancer …