Digital Commons Network^™

Diagnostic Criteria And Management Of Melas And Stroke-Like Episodes: Consensus-Based Statements, Michelangelo Mancuso, Marcello Bellusci, Valerio Carelli, Irenaeus De Coo, Daria Diodato, Felix Distelmaier, Omar Hikmat, Michio Hirano, Rita Horvath, Amel Karaa, Thomas Klopstock, Mary Kay Koenig, Cornelia Kornblum, Chiara La Morgia, Piervito Lopriore, Mika Henrik Martikainen, Robert Mcfarland, Olimpia Musumeci, Robert D S Pitceathly, Guido Primiano, Shamima Rahman, Fernando Scaglia, Andrew Schaefer, Manuel Schiff, Luisa Semmler, Costanza Lamperti, Serenella Servidei

Faculty, Staff and Student Publications

Background and purpose: Mitochondrial Encephalomyopathy, Lactic acidosis and Stroke-like episodes (MELAS) is a rare multisystem mitochondrial disorder with clinical heterogeneity. Diagnostic criteria and management strategies for MELAS and mitochondrial stroke-like episodes (SLE) remain inconsistent. This work provides international consensus recommendations on the definition, diagnosis, and management of MELAS and SLE in pediatric and adult populations.

Methods: An international Delphi consensus process was conducted within the European Reference Network for Neuromuscular Diseases (ERN EURO-NMD), in collaboration with the US Mitochondrial Medicine Society, the ERN for Hereditary Metabolic Disorders (MetabERN), and patient representatives. Following a systematic literature review, 54 statements addressing diagnostic …

Weaning Drives Microbiome-Mediated Epigenetic Regulation To Shape Immune Memory In Mice, Li Yang, Robert C Peery, Shirui Zhou, Xiaomin Chen, Leah M Farmer, Fabiola Gutierrez, Stephanie Fowler, Lanjing Zhang, Julia M Salamat, Karen Riggins, Jiejun Shi, Lanlan Shen

Children’s Nutrition Research Center Staff Publications

During weaning, the transition to solid food diversifies the gut microbiome, triggering a programmed immune response critical for long-lasting mucosal immunity. Previous work showed that the gut microbiome mediates epigenetic development in intestinal stem cells (ISCs) during suckling, but what happens during weaning is unclear. Here, genome-wide profiling revealed that weaning-driven microbiome changes shape the DNA methylome and transcriptome of murine ISCs in an IFNγ-dependent manner. Specifically, we observe demethylation of enhancer elements essential for MHC class II genes, which results in a transcriptional memory that persists through differentiation into adulthood. IFNγ blockade, or low-dose penicillin to target Gram-positive bacteria, …

Body Mass Index And Survival In Children Receiving Extracorporeal Membrane Oxygenation, Pilar Anton-Martin, Keith Baxelbaum, Shilpa Vellore, Erika O'Neil, Vinai Modem, Sameer Thadani

Faculty, Staff and Students Publications

Importance: Underweight and obesity represent opposite ends of the nutritional risk spectrum that negatively affect children's health worldwide. Both conditions have been associated with increased mortality in pediatric patients receiving extracorporeal membrane oxygenation (ECMO) support.

Objective: To investigate the association of underweight and obesity status with pediatric ECMO outcomes using body mass index (BMI) z scores.

Design, setting, and participants: This retrospective cohort analysis used data from the Extracorporeal Life Support Organization (ELSO) database from January 1, 2019, to December 31, 2023. Participants included all pediatric patients from international ECMO centers aged 29 days to 18 years who received ECMO …

Novel Variants Identified In Families With Snx27 -Related Neurodevelopmental Disorder, Aiding In Characterizing Its Genotypic And Phenotypic Spectrum, Tayyaba Shan, Abrar Hussain, Anushree Acharya, Mulazim Hussain, Yumei Li, Hafiz Muhammad Jafar Hussain, Kiran Afshan, Suzanne M Leal, Rui Chen, Asif Mir, Isabelle Schrauwen, Sabika Firasat

Faculty, Staff and Students Publications

Background:

Sorting Nexin 27 (SNX27), a key regulator of synaptic receptor trafficking and endosomal recycling, has been implicated in maintaining synaptic homeostasis and cognitive function. To date, variants in SNX27 have been reported in a small number of patients across three publications with severe neurodevelopmental phenotypes. However, the genetic and functional landscape of SNX27-related disorders remains poorly understood, and further evidence is needed to confirm its association with disease and to better delineate the associated phenotype.

Methods and Results:

Two unrelated Pakistani families with a total of five affected individuals segregating a neurodevelopmental disorder were investigated via exome …

Small Award, Big Ripple, Beryl White-Bing

Library Faculty Presentations & Publications

Innovation in libraries does not always begin with large national grants or major institutional investments. Often, meaningful experimentation begins with small regional funding opportunities that allow librarians to test new ideas and technologies. For academic libraries, these modest awards can serve as catalysts for interdisciplinary collaboration, new teaching tools, and innovative research partnerships.

Neural Progenitor Cell Proliferation In Response To A High-Fat Diet And Fgfr1 Inactivation, Alexandra Natalie Chistoserdov

Undergraduate Honors Theses

Tanycytes are radial glial-like astrocytes whose cell bodies line the third ventricle (3V) with long processes extending into the hypothalamic parenchyma. In adult mice, tanycytes retain stem cell properties, with their daughter cells integrating into the median eminence or mediobasal hypothalamus. Tanycytes are implicated in glucose homeostasis and appetitive behaviors not only via the maintenance of hypothalamic cell populations, but also by their glucose, fatty acid, and hormone-sensing capabilities. Fibroblast Growth Factor Receptor 1 (FGFR1) is a tyrosine kinase receptor expressed in neural progenitor cells, including tanycytes, where it induces cell proliferation and therefore plays an integral role in neural …

Iron Deficiency And Depressive Symptoms: Effects Of Racial And Ethnic Disparity In Two Reproductive-Aged Us Women, Alexis Monkhouse

USF Tampa Graduate Theses and Dissertations

Problem: Reproductive- aged women are one of the populations most at risk for iron deficiency and depression in the United States. While many studies have looked at the relationship between these two illnesses, none have explored it from a biocultural framework, examining how race/ethnicity affects this relationship. Using data from NHANES, this thesis examined the relationship between iron status (total body iron) and depressive symptoms (PHQ-9) among reproductive-aged women in the U.S. and how race/ethnicity affects it. Methods. NHANES survey data from 2005-2010 were pulled. Demographic and laboratory data were used to determine eligibility, total body iron, and depressive scores. …

Predictors Of Delayed Recovery In Ambulatory Advanced Endoscopic Procedures, Zoilo K Suarez, Alexandria Lenyo, Philip M Frasse, Derek J Platt, Thomas Hollander, Talwinder Nagi, Michael Dedonno, Vladimir Kushnir, Juan Reyes Genere

2020-Current year OA Pubs

BACKGROUND: There is a scarcity of data evaluating patient-related outcomes of advanced or complex endoscopy (ACE) through the post-anesthesia recovery course. Yet, gastrointestinal distress following ACE can occur commonly, and this may impact recovery length of stay and the approach to post-anesthesia care. This study aimed to describe post-procedural symptoms in patients undergoing ACE and identify factors that influence recovery time and course.

METHODS: We retrospectively reviewed a prospectively collected database of patients who underwent ambulatory ACE. Procedural-related symptoms, recovery time, dismissal rate, and adverse events (AE) were recorded. Factors associated with extended recovery time were analyzed using multiple regression …

Knowledge, Attitudes, And Practices Among Sexually Active Individuals Toward Trichomoniasis In The Ashaiman Municipality, Ghana: A Cross-Sectional Study, Christopher Yaw Dumevi, Percival Delali Agordoh, Yaw Osei Owusu, Josephine Afi Nukpedu Banini, Roberta Araba Amoquandoh, George Boateng Kyei, Patience B Tetteh-Quarcoo, Irene Ayi, Patrick F Ayeh-Kumi

2020-Current year OA Pubs

BACKGROUND AND AIMS: Trichomoniasis is a significant public health concern due to its implications for reproductive health and HIV transmission. Despite its prevalence, there is limited understanding of community knowledge, attitudes, and practices (KAP) regarding trichomoniasis in Ghana. This study aimed to assess KAP toward trichomoniasis among sexually active individuals in the Ashaiman Municipality of the Greater Accra Region.

METHODS: A hospital-based cross-sectional study was conducted from February to April 2024 among 397 sexually active individuals aged 15-65 years. Participants were selected via simple random sampling. Data were analyzed using SPSS version 26 and Stata version 17. Descriptive statistics summarized …

The Tribal Energy Act: A Necessary Step Toward The Electrification Of The Navajo Nation, Carington Lowe, Michael Hamersky

Pepperdine Law Review

The Navajo Nation stands as a sovereign nation, yet many families still lack access to electricity because of enduring historical, structural, and regulatory barriers. This Article identifies the legal and technical barriers that have hindered meaningful progress and argues that supplementing the utility grid with distributed energy resources, such as biodigesters, offers a viable path toward electrification, particularly for remote and rural communities within the Navajo Nation. Biodigesters convert organic waste generated through community practices, such as sheep raising, into biogas through an anaerobic process. This form of energy reflects circular economy principles while also aligning with Diné cultural practices …

Farmers Markets And Produce Purchasing Behaviors Among University Faculty And Staff, Kritika Gupta, Laurel Lambert, Jangwoo Jo, Selby Rebecca Entrekin, Georgianna Mann

Journal of Public Health in the Deep South

Background: This study explores produce purchasing criteria (PPC) and produce purchasing frequency (PPF) among university faculty and staff, a population often underrepresented in dietary behavior research.

Purpose: To identify distinct PPC profiles among university faculty and staff and examine how these profiles are associated with PPF and farmers market usage, while also assessing the role of demographic and behavioral factors in shaping these relationships.

Methods: Using a 29-item online survey administered to faculty and staff at a southern United States university (N = 175), three distinct PPC clusters were identified: health/label conscious, utilitarian, and no-specified-criteria consumers. Statistical analyses — including …

Red Chain Feeds Dealer Publication

Universal Mills Collection

A Red Chain Feeds magazine announcing the appointment of a new Red Chain dealer in the community.

2022 Uninsured Adult Healthcare Safety Net Annual Report, Tennessee. Department Of Health.

Healthcare Safety Net Annual Report

No abstract provided.

Metabolomics In Precision Medicine: Application And Prospect In Cancer Research, Ming-Shi Shiao

Journal of Food and Drug Analysis

Metabolomics is the most recent and final discipline among the post-genomic, multiomics fields. It encompasses key technologies in systems biology, providing an overview of low-molecular-weight metabolites while examining disturbances to offer pathophysiological explanations. The two key analytical tools in metabolomics are nuclear magnetic resonance spectroscopy and mass spectrometry, which includes gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry. Metabolomic research relies on a three-stage data generation process: the first stage involves precise analytical chemistry to produce data; the second stage employs multivariate statistical analysis; and the last stage uses big data as a reference for comparison to establish biochemical, metabolic, and …

College Football Free Agency: The Transactional Nature Of Big-Time College Football Recruiting, Chris Corr, Branden Johnson, Amanda L. Paule-Koba

Journal of Issues in Intercollegiate Athletics

This study explored how the transfer portal has transformed college football recruiting by disrupting traditional relationship-based practices and accelerating the shift toward a transactional performance-driven model. Drawing on Bourdieu’s concepts of habitus, field, and capital, the research examines how recruiting coordinators navigate evolving pressures around talent acquisition, NIL compensation, and compressed recruiting timelines. Findings from comprehensive interviews with five Power-4 recruiting personnel reveal that relationships are increasingly leveraged for short-term gain. The findings of this study indicate the transfer portal has created an opaque high-stakes marketplace where trust is limited, valuation is speculative, and institutional pedigree/resources heavily influence opportunities. The …

Tennessee Diabetes Action Report, February 2023, Tennessee. Department Of Health.

Diabetes Action Report

No abstract provided.

Tennessee Diabetes Action Report, February 2025, Tennessee. Department Of Health.

Diabetes Action Report

No abstract provided.

Cancer In Tennessee 2016-2020, Tennessee. Department Of Health.

Cancer in Tennessee

No abstract provided.

Annual Safe Schools Report 2022-2023, Tennessee. Department Of Education.

Safe & Supportive Schools Report

No abstract provided.

Annual Safe Schools Report, 2019-20 School Year, Tennessee. Department Of Education.

Safe & Supportive Schools Report

No abstract provided.

Coordinated School Health 2024-25 Annual Report, Tennessee. Department Of Education.

Coordinated School Health

No abstract provided.

Approved Courses 3-31-26, Angela Brock

Individual Course Committee (ICC)

No abstract provided.

Effects Of Exercise Of Cognitive Development In Young Children, Hannah Schlomann

Psychology Student Publications

This paper examines the relationship between physical activity and cognitive development in young children ages 0-5. Increased tablet time and sedentary behavior is becoming common for young children. This paper examines the effect of four categories of movement including screen based sedentary behavior, non-screen based sedentary behavior, light physical activity, and moderate to rigorous physical activity, as well as the effects of motor ability on cognitive development.

The Predictive Ability Of Child Characteristics And Parenting Factors On Four Developmental Domains In Toddlers, Melly Latifah, Dwi Hastuti, Neti Hernawati, Reisi Nurdiani, Raihan Ainun Hasanah

Jurnal Keperawatan Indonesia

Stunting is a chronic condition that has a significant impact on child development. This phenomenon is primarily caused by prolonged nutritional deficiency, especially during the first 1,000 days of life. In addition, as family factors also play a crucial role in children’s development, this study aims to analyze the influence of child and family characteristics, mother–child attachment, parenting practices, and the nutritional status of children (stunted/non-stunted) on children’s gross motor, fine motor, language, and personal–social skills. This study used a quantitative design with an explanatory approach involving 202 mother–child pairs with children aged 12–36 months. The findings show that healthcare …

Cigarettes Versus Electronic Cigarettes: The Effects On The Oral Cavity, Paolo Boffano, Muhammad Ruslin, Andrea Melle

International Arab Journal of Dentistry

Objectives: To date, there is a large amount of scientific evidence on the effects of smoke-free products on oral health, highlighting their potential in reducing the risk of causing and progressing smoking-related diseases. In contrast to the last statement, other studies confirm the cytotoxic and tissue effects of nicotine-containing e-cigarette liquid. The purpose of this study was to review the literature and to evaluate the damage caused by cigarette smoking in comparison with that caused by e-cigarettes.

Methods: Our study considered the consultation of the bibliographic databases “Medical Literature Analysis and Retrieval System”. The research was carried out by using …

Risk Factors Of Leptospirosis Among Agricultural Workers In Southeast Asia: Literature Review, Ronggo Adi Wibowo, Wawa Najwa Nurzakia, Meirany Sasitha Kirana, Yulia Arthemisia Wijaya, Jasmine Ayumaharani Sekaryudha, Dwi Sarwani Sri Rejeki, Rosita Dwi Jayanti

Jurnal Epidemiologi Kesehatan Indonesia

The agricultural sector is the primary source of livelihood for communities in Southeast Asia; however, these activities increase the risk of exposure to zoonotic diseases, particularly leptospirosis. Southeast Asia is one of the regions with the highest incidence of leptospirosis in the world. This literature review aims to identify risk factors for leptospirosis among agricultural workers in Southeast Asia. The search for research articles utilized three databases (Google Scholar, PubMed, and ScienceDirect) using a descriptive approach based on literature review and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. A total of 9,800 articles were screened for …

Factors Associated With Stunting Among Children Aged 6 – 59 Months Attending Integrated Health Post (Posyandu) In Selapajang And Kedaung Wetan Villages, Neglasari Sub-District, Tangerang City: A Matched Case-Control Study, Michael Alexander Solang, Joue Abraham Trixie, Gloria Semula, Tiona Simamora, Conny Tanjung

Jurnal Epidemiologi Kesehatan Indonesia

Stunting is a problem in Indonesia. In 2022, Kedaung Wetan and Selapajang Villages in Neglasari sub-district, Tangerang City, were identified as a priority. This study aimed to identify factors associated with stunting among children (6 – 59 months) in these villages. A matched case-control study consisting of 214 children (107 cases and 107 controls) was conducted, with individual matching based on age, sex, and prematurity at birth. Cases were children with height-for-age (H/A) measurement less than -2SD (according to WHO standard), while controls were children with H/A equal to or greater than -2SD. Conditional logistic regression was used for the …

Future Prospects Of Pediatrician Talent Development: Focusing On Early Childhood Health To Pioneer A New Chapter In Pediatric Care, Yueh-Ping Liu

Journal of Medical Education

Taiwan's declining fertility rate is reshaping the pediatric care landscape. The demands of child health care encompass acute and critical care, chronic disease management, complex diagnostic conditions, as well as developmental and mental health support. In response, the Ministry of Health and Welfare's Program for Excellence in Child Health Care and the Project of Holistic Physicians for Young Children represent a strategic transition toward proactive, community-anchored child health stewardship. By integrating preventive services, developmental surveillance, case management, and cross-sector coordination, these initiatives strengthen early detection and timely intervention while redefining pediatricians as key actors within the social safety net. Embedding …

Approved Programs 3-31-26, Angela Brock

Programs Committee (PC)

No abstract provided.

Program Agenda 3-31-26, Angela Brock

Programs Committee (PC)

No abstract provided.