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Beyond Lipid-Lowering: Pleiotropic Effects Of Statins In Inflammation, Coagulation, And Cell Proliferation – Mechanisms And Clinical Implications, Kasidid Lawongsa, Yutthana Pansuwan, Supanut Kumjan

Chulalongkorn Medical Journal

Statins are widely used lipid-lowering agents that significantly reduce cardiovascular morbidity and mortality through inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. Beyond their cholesterol-lowering properties, increasing evidence demonstrates that statins exert several pleiotropic effects independent of lipid reduction. These effects include anti-inflammatory, anti-thrombotic, and anti-proliferative actions mediated primarily through inhibition of the mevalonate pathway and downstream signaling molecules such as Rho, Rac, and Ras. Experimental and clinical studies have suggested potential benefits of statins in various non-cardiovascular conditions, including autoimmune diseases, venous thromboembolism, sepsis-associated coagulopathy, and certain malignancies. In addition, pharmacoepidemiologic studies have provided insights into the real-world effects and …

Evaluation Of Mdm2 Mrna Expression According To Clinicopathological Characteristics In Oral Squamous Cell Carcinoma (Oscc) Patients, Tirta Wardana

Chulalongkorn Medical Journal

Background: The murine double minute 2 (MDM2) gene encodes an E3 ubiquitin ligase that targets p53 for degradation, thereby influencing the pathogenesis of oral squamous cell carcinoma (OSCC).

Objective. The present study investigates MDM2 mRNA expression and its association with clinical and pathological characteristics in OSCC patients.

Methods: We conducted an observational-analytical study using a cross-sectional design. The study involved 39 OSCC patients. RNA extraction, cDNA synthesis, and quantitative PCR (qPCR) were performed. We quantified relative MDM2 mRNA expression using the Livak method (2-ΔΔCT) and GenEX MultiD software version 6.0. Statistical significance was assessed using independent t-tests.

Results: Although no …

Factors Associated With Colorectal Cancer Screening Decision-Making Among Older Adults At The Comprehensive Geriatric Clinic, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chalisa Thanapura, Nawasiri Siriprasert, Thacha Pithayapibulpong, Bhorn-Ake Manasvanich, Vichai Viriyautsahakul

Chulalongkorn Medical Journal

Abstract

Background: The incidence of colorectal cancer (CRC) in Thailand is constantly increasing, and is highest in individuals aged 60-75 years. However, the number of older individuals undergoing CRC screening remains suboptimal.

Objective: This study aimed to identify factors associated with CRC screening decision-making among Thai older adults attending the Comprehensive Geriatric Clinic at King Chulalongkorn Memorial Hospital. The secondary objective was to identify factors associated with the choice of screening method—colonoscopy versus fecal occult blood testing (FOBT)

Methods: A cross-sectional study was conducted using a data record form at the Comprehensive Geriatrics Clinic, King Chulalongkorn Memorial Hospital in Bangkok, …

Assessing The Reliability Of Machine Learning Models In Classifying Depression Severity Using Facebook Text, Keito Yoneyama

Chulalongkorn Medical Journal

Depression is a growing global issue that requires urgent attention, particularly in Thailand. Without timely intervention, it can lead to serious consequences such as health complications, reduced social participation, and even suicide. Consequently, there has been increased research focused on developing algorithms to identify and classify social media data according to depression severity. This study aimed to evaluate the extent to which such algorithms are a suitable tool for the preliminary classification of Thai Facebook text into different levels of depression severity. The methodology involved data collection through surveys and Facebook scraping, followed by data preprocessing, feature engineering, and model …

The Expansive Power Of The House Of Representatives As A Precondition For Constitutional Rot, Isnawati Isnawati, Adam Setiawan

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

This study examines how the expansive powers of the Indonesian House of Representatives have contributed to constitutional rot because those powers no longer operate effectively or proportionately. It identifies dysfunction in the House of Representatives through weak legislative performance, inadequate oversight of the executive branch, and transactional political practices in appointment processes. Using a doctrinal legal method and contemporary constitutional theory as its analytical framework, this study argues that the expansive powers of the House of Representatives constitute a precondition for constitutional rot, evidenced by the poor exercise of legislative authority and institutional intervention through amendments to the Rules of …

Bank Indonesia's Floating Rate Notes (Bi-Frn) And Federal Reserve Instruments: A Comparative Analysis From An Institutional-Legal Perspective, Abdul Madjid Podungge

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

This paper analyses the legal validity of Bank Indonesia's Floating Rate Notes (BI-FRN) following the Law Number 4 of 2023 on the Development and Strengthening of the Financial Sector (P2SK Law) from a public law viewpoint. Doctrinal legal research utilises statutory, conceptual, and comparative methodologies, augmented by literature network visualisation, to pinpoint structural deficiencies. The network analysis reveals a significant divide between technical financial transactions and administrative legal oversight. The findings indicate that Article 11 of the P2SK Law enforces a stringent priority clause that centres monetary policy solely on Rupiah stability. This legal barrier prohibits abuse of power by …

Shaping Disease: Colonial Stigma And The Politics Of Health In Banyuwangi, The Early Twentieth Century, Rifa'i Shodiq Fathoni, Skriptyan Noor Hidayatullah Syuhri, Vini’Matu Hikmah, Ardhita Zahra Namira

Paradigma: Jurnal Kajian Budaya

This article examines the colonial stigma attached to Banyuwangi as an “unhealthy region” in the early 20th century, a label used to justify massive exploitation of its natural resources. Using a historical method, this research analyzes how this stigma not only served as a tool for colonial legitimation but also causatively created conditions that triggered ecological disasters and a public health crisis in a previously isolated area. Through an analysis of primary sources such as colonial reports, health journals, and newspapers, this article traces how large-scale plantation exploitation, enabled by the stigma, led to deforestation, uncontrolled labor migration, and poor …

Transmutation Of Psychological Phenomena (Academic Burnout And Fomo) Into Cyanotype Art Creation, Zulfan Ali Mujtaba, Adi Kuntoro

Paradigma: Jurnal Kajian Budaya

The pressure of hustle culture and the Fear of Missing Out (FOMO) in the digital era have triggered an escalation of academic burnout among students, demanding alternative psychological recovery interventions beyond verbal clinical approaches. This research aims to explore the creation of alternative Cyanotype photography as a medium for catharsis and resistance against toxic productivity. Utilizing a Practice-Based Research methodology with an autoethnographic approach, data were extracted from the researcher's subjective experiences and transmuted into a visual artifact titled "Metamorfosis yang Lelah". The cultural studies approach and wabi-sabi aesthetics are specifically applied to analyze visual elements in the Prussian Blue …

Do Dynamic Capabilities Moderate The Effect Of Managerial Attitudes On E-Marketing Adoption? Evidence From Small And Medium Tourism Enterprises In Zanzibar, Hilal Maabad Ame, Omari Khalifa Mbura, Amani Gration Tegambwage

Business Management Review

This study examines the influence of managerial attitudes and dynamic capabilities on e-marketing adoption among Small and Medium Tourism Enterprises (SMTEs) in Zanzibar. Grounded in the Decomposed Theory of Planned Behaviour (DTPB) and Dynamic Capabilities Theory (DCT), the study tests the effects of perceived ease of use, perceived usefulness, compatibility, and perceived security on e-marketing adoption, with dynamic capabilities examined as a moderating factor. Data were collected from 216 SMTEs operating in the Urban and South Regions of Zanzibar and analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM). The results indicate that perceived ease of use and perceived security …

Illinois Model Programs Of Study Guide: Digital Technology (Draft For Public Comment), Education Systems Center

Practitioner Toolkits and Resources

This draft was available for public comment through September 30, 2026. A final version will be released in October 2026.

Illinois Model Programs Of Study: Overview Guide (Draft For Public Comment), Education Systems Center

Practitioner Toolkits and Resources

This draft was available for public comment through September 30, 2026. A final version will be released in October 2026.

Gender Inequality In Political Participation: Focusing On Social Structure, Legal Instrument, And Social And Cultural Change, Eakpant Pindavanija

Indonesia Law Review

The transition of Thailand's political system from absolute monarchy to parliamentary constitutional monarchy in 1932 brought about opportunity in developing democratic society in this country. However, 90 years after the political transition Thailand is still struggling to pursue democratic stability while the degree of authoritarianism is very high due to several political, economic, and social factors. This circumstance raises concerns on the democratic development in this country. This paper is written based on Westminster Foundation for Democracy (Thailand)’s preliminary report on situation analysis of gender equality for the female and other genders who are the candidates, and potential candidates to …

Two Paths Of Criminal Law Reform: From Shared Colonial Legacies To Divergent Legal Trajectories In Indonesia And Malaysia, Ade Adhari, Charisse Evania Tansir

Indonesia Law Review

Despite sharing colonial legacies in the development of their criminal law systems, Indonesia and Malaysia have pursued markedly different paths of criminal law reform, reflecting their distinct legal traditions and legislative philosophies. This article examines how these divergent reform trajectories are manifested through a comparative analysis of Indonesia's Law Number 1 of 2023 on the Criminal Code and Malaysia's Penal Code (Act 574). Focusing on three analytical dimensions—the principle of legality, criminal responsibility, and sentencing policy—the study adopts a normative legal research method supported by statutory, conceptual, and comparative approaches. Legal materials were collected through library-based research and analysed qualitatively …

The Eu’S Copyright Legislation For Generative Ai: Relevant To Indonesia?, Yolanda Simbolon

Indonesia Law Review

Tremendously copyrighted works are used to train Generative AI (Gen-AI) at the epicenter of current sectors. In many countries, there is a dilemma as to whether the amount of data used may infringe copyright. The EU is the one that has regulations on the use of copyrighted works as text and data mining (TDM) to train GenAI.  Meanwhile, Indonesia does not yet have a regulation, even though Gen-AI has been massively developed in Indonesia. Data has been used freely to train Gen-AI, even to modify works and damage the author’s reputation. This article investigates whether the EU’s copyright of Gen-AI …

Uhsp Student Handbook 2026-2027

Handbooks

No abstract provided.

Schiff Base Synthesis, Characterization And Computational Analysis For Potential Antibacterial Agents, L. N. G. K. Suranjith, M. S. D. Fernando

Journal of Innovation in Science, Engineering and Technology

Schiff bases are an important class of imine compounds known for their structural versatility and biological activities, particularly as potential antimicrobial agents characterized by the azomethine (–C=N–) functional group, are widely recognized for its diverse biological activities. This study focuses on the synthesis and characterization of (E)-N-(3-phenylprop-2-en-1-ylidene)aniline to evaluate its potential as an antibacterial agent. The compound was synthesized via acid-catalyzed condensation of aniline and cinnamaldehyde under reflux for 2 hours in absolute ethanol. After purification through recrystallisation, the structure was confirmed using UV–Visible, FT-IR, ¹H-NMR, and ¹³C-NMR spectroscopy. Thermal stability was assessed with thermogravimetric analysis (TGA), while …

Fall 2026 Census Enrollment Indicators Campus Report Tables 1-3, Systems Intelligence And Data Analytics, University Of Nebraska At Omaha

Enrollment Reports

No abstract provided.

Awareness Of Intellectual Property Rights Among Graduate Students At Umm Al-Qura University: A Case Study, Abdullah Bin Abdulrahman Al-Mahdar

Journal of Arts and Social Sciences

This study aimed to examine the level of awareness of intellectual property rights among graduate students at Umm Al- Qura University and to measure the impact of demographic characteristics on their awareness of these rights. The study adopted the case study method and used a questionnaire as the primary data collection instrument. The study sample consisted of 115 male and female graduate students enrolled at the university. The findings revealed that most participants had a general awareness of the existence of intellectual property protection laws in Saudi Arabia. However, fewer than half were aware of the official national authority responsible …

From Contested Rights To Perceived Threats: The Securitization Of Lgbt And Its Human Rights Implications In Indonesia, Melkias Hetharia, Basir Rohrohmana

Indonesia Law Review

Debates on LGBT rights in Indonesia have largely centred on the legal recognition of same-sex relationships and their compatibility with religion, Pancasila, and the constitutional framework. Recent developments, however, require the discussion to move beyond the question of recognition. This article examines the evolving legal and policy treatment of LGBT persons in Indonesia, particularly following Presidential Regulation No. 111 of 2025, which identifies the “spread of LGBTQ culture” as a non-military threat. Using normative legal research and securitization theory, the article analyses Indonesian constitutional principles, marriage and human rights law, relevant Constitutional Court jurisprudence, defence policy, and documented experiences of …

Mcsa Forum Minutes 08/31/2026, Morris Campus Student Association

Morris Campus Student Association

No abstract provided.

Female Perpetrators In Nazi Germany: The Effects Of Nazi Ideology And Radicalization On Three Female Concentration Camp Perpetrators, Stephanie Afonso

Graduate Masters Theses

The Second World War in Germany saw the largest number of civilian German women participating in brutal violence against Jewish peoples. The combination of sources used aids in presenting a broader image of these women both within the concentration camps and during their trials. This thesis argues the effects of Nazi ideology and radicalization on the three main subjects, Irma Grese, Maria Mandl, and Ilse Koch. Equally as important is how the American public perceived them and their roles during their respective post-war trials--which looked at them through the lens of femininity and sexuality. Within that violence came the transgression …

Infrared Detectability Of Whale Species And Behaviors To Enhance Automatic Detection For Real-Time Vessel Strike Avoidance, Laura J. Howes

Graduate Masters Theses

Real-time detection of large whales at sea is critical for mitigating serious injury and mortality from ship strikes and other human activities such as seismic surveys, especially for endangered species such as the critically endangered North Atlantic Right Whale (Eubalaena glacialis). Traditional marine mammal observers are limited by environmental conditions and human factors, necessitating a robust, 24-hour solution. This study investigates the efficacy of a novel onboard detection tool infrared (IR) technology to detect whale blows and body parts. While IR is a promising advancement, its performance under varying sea conditions (e.g., fog, humidity) and its ability to …

Beyond A Little Italy: Italian Community Formation In Washington, D.C., Kathleen P C Millander

Graduate Masters Theses

This thesis examines the development of the Italian immigrant community in Washington, DC, from the early nineteenth century through the beginning of the Second World War. Unlike the dense ethnic enclaves that characterized Italian settlement in many American industrial and port cities, Washington never developed a recognizable Little Italy. Nevertheless, Italians in the nation's capital constructed a cohesive community through social, religious, familial, and economic networks that connected a geographically dispersed population.

Drawing on extensive original archival research, including oral histories, personal memoirs, parish records, newspapers, and manuscript collections, this thesis reconstructs the experiences of Washington's Italian immigrants and their …

'In America On Twofold Mission': Elite Filipina Women On The U.S. Stage, 1898-1929, Catherine D. Mayfield

Graduate Masters Theses

After more than 300 years of Spanish colonization of the Philippines, the United States’ acquisition of las Islas Filipinas at the end of the Spanish-American War introduced the Philippine Islands to yet another colonizer. Amidst a backdrop of insurgent resistance and the building of a U.S.-based education and government system under the guise of “benevolent assimilation,” elite Filipina women navigated a mélange of cultural values and the possibility of new public roles. Filipino “elites,” those with political or economic power at the upper echelons of Philippine society, played key collaborative roles for the U.S. colonial regime. Yet the actions and …

A Variational Algorithm For Preparing Superoptimal Thermal States For Quantum Thermometric Measurement Adaptable To Nisq Hardware, Nicholas Donatelli

Graduate Masters Theses

The conditional thermal state (CTS) is a probe-specific quantum thermal state that is known to outperform the Gibbs state in quantum thermometric measurements at sufficiently low temperatures. This thesis introduces a variational quantum algorithm designed to prepare the CTS on quantum computing hardware which optimizes the angular parameters of the quantum gates that comprise the ansatz circuit and, for the one-qubit case, minimizes relative infidelity of the output state with the known CTS. Using noiseless numerical simulations (SPSA with Qiskit), attempting to prepare the CTS yielded relative infidelities with the known CTS on the order of $10^{-5}$ for most parameter …

Going The Distance: How The Disney Renaissance Illustrated The Social And Cultural Changes In America During The 1990s, Deborah A. Bates

Graduate Masters Theses

The cultural and social history of America in the 90s is examined in this thesis by looking at the Disney Renaissance, a period of ten films made by the Walt Disney Animation Studios (WDAS). This thesis illustrates how the animators were able to seamlessly incorporate important societal trends of the 90s into their films, portraying a changing world within their films. As they were creating a new style of the animated movie musical, they were creating works that connected to the audiences watching in new ways, by putting up a reflection of society within their films. The way that the …

Toward The Study Of Photon Dynamics In Non-Separable Spacetimes, Kara Nelson

Graduate Masters Theses

Black holes provide a unique laboratory for testing general relativity in the strong-field regime through observations such as black hole images and gravitational wave signals. Comparing theoretical predictions with these observations requires accurate numerical models of photon trajectories. This thesis develops and validates a generalized ray-tracing framework for computing null geodesics in stationary, axisymmetric spacetimes. Unlike many existing ray-tracing methods, the framework does not rely on metric separability or analytic solutions, allowing it to be applied to both separable and non-separable spacetimes. The framework is validated by reproducing known Schwarzschild and Kerr results and is applied to a quasi-Kerr spacetime …

The Furry Community As A Case Study In Identity-Related Conflict, Patrick Hampton

Graduate Masters Theses

The “furry” community has gained notoriety both on the internet and in physical spaces for the dramatic portrayal of animal-based personas referred to as “fursonas.” This group has become the subject of ridicule and moral concern due to the occasionally controversial nature of the content produced by some members of the community. However, there are many different interpretations both within and outside of the community around what the community entails. In this thesis, I examine how the furry community and the identity of its members is shaped by external pressure or social stigmatization? I answer this through the following three …

Cultural Responsiveness: Examining Assessments Of Therapists For Ethical And Clinical Outcomes (Create Clout), Tsotso T. Ablorh

Graduate Doctoral Dissertations

The Multicultural Counseling Competencies (MCC) and Multicultural and Social Justice Counseling Competencies (MSJCC) are well-researched and supported counseling practices for decreasing microaggressions in therapy and consequent attrition, lack of satisfaction, and maltreatment (Ratts et al., 2016; Sue et al., 1982). However, scholars critique existing methods for measuring therapists’ cultural responsiveness for being disconnected from therapeutic process and outcomes (Hays, 2020; Wilcox et al., 2020). This study examined which MSJCC measures associated with variables clinically and ethically relevant to better treatment outcomes and lower microaggressive, neglectful, and stereotypical treatment for hypothetical Black, female clients by White therapists. 62 White psychologists in …

Towards The Development Of Targeted And Quantitative Mass Spectrometry Methods For The Investigation Of Biological Systems, William Gazlay

Graduate Doctoral Dissertations

Mass spectrometry has become an essential analytical platform for the characterization of complex biological systems, enabling detailed investigation of molecular structure, post-translational modifications, and protein expression. This dissertation applies modern mass spectrometry methodologies to three analytical challenges spanning lipidomics and proteomics.

The first study examined the influence of complexing agents on the sensitivity of collision-induced dissociation (CID) spectra to fatty acid position in synthetic XYZ-type triglycerides. Comparison of ammonium, lithium, and sodium adducts demonstrated that alkali metal adducts provide substantially improved positional sensitivity and greater consistency across triglyceride systems. These findings support the use of lithium and sodium adducts for …