Digital Commons Network^™

Environmental Awareness And Community Sentiments In A Superfund Site: A Study Of South Chattanooga, Mia Dial

Honors Theses

The concept of environmental injustice refers to the disproportionate exposure of marginalized communities to environmental hazards, often resulting from the placement of industrial sites, waste facilities, or other environmentally harmful infrastructure in areas with limited political and economic power. Alton Park, a historically underserved neighborhood in Chattanooga, Tennessee, faces elevated environmental risks due to its proximity to the South Chattanooga Lead Superfund Site and legacy industrial contamination. This study used semi-structured individual interviews to assess community awareness, perceptions, and behaviors related to environmental hazards in Alton Park. Residents generally reported some awareness of the Superfund site, though knowledge was often …

Integrating Growth Performance And Pathogen Detection To Investigate Disease Resilience In Commercial Swine, Emmalise Hope Marie Meyer

Department of Animal Science: Dissertations, Theses, and Student Research

Disease resilience is an important trait in commercial swine production, influencing both animal health and growth performance under natural disease challenge. The primary objective of this study was to integrate growth performance data with longitudinal pathogen detection to better understand factors contributing to disease resilience in commercial pigs. A population of 1,014 pigs across four batches was monitored from weaning through the grow-finish phase, with body weights collected to calculate average daily gain (ADG). Genome-wide association analyses were conducted using BayesC and BayesIM approaches to identify genomic regions associated with growth performance. Longitudinal pathogen surveillance was performed using pen-level oral …

Empowering Women Journalists’ Preparedness: An Evaluation Of Hostile Environment First Aid Training (Hefat) And Its Implementation In Academic Journalism Programs, Vanessa Charlot

Electronic Theses and Dissertations

This Dissertation in Practice examines the potential integration of gender-sensitive Hostile Environment and First Aid Training (HEFAT) into journalism education to enhance the preparedness of women journalists for high-risk reporting contexts. Manuscript I investigates existing gaps in curricula, highlighting the distinct physical, psychological, and ethical risks encountered by women in hostile environments. Manuscript II outlines a framework for qualitatively evaluating an adapted HEFAT program, considering how identity-informed and trauma-sensitive approaches might strengthen student safety, resilience, and ethical decision-making. Manuscript III explores leadership strategies for implementing inclusive, trauma-informed HEFAT curricula, emphasizing reflexive practice and self-authorship as mechanisms for fostering transformative, equity-driven …

The Hitchhiker's Guide To The Host: Fleas And The History Of Pikas In North America, Josh Pletcher

All NMU Master's Theses

Parasite phylogenetics can offer windows into the cryptic evolutionary history of hosts, often highlighting events that are not recorded by the phylogenetics of the host. Pikas (small lagomorphs) host a diverse parasite community comprising endoparasites (e.g., coccidians, nematodes, and cestodes) and ectoparasites (e.g., fleas and mites). Phylogenetic analysis of pika endoparasites has revealed pikas evolved in Asia and colonized North America in two waves, and that contact between these two pika lineages allowed parasites to be transferred from one lineage to another and to survive the extinction of their original host. To uncover these cryptic histories, understanding the biogeography of …

Pathogenic Leptospira Adherence To Epithelial Cells: A Comparison Between Different Hosts Based On Outcome Of Disease, Imaan G. Masood

Honors Scholar Theses

Leptospirosis is a neglected zoonotic disease with global distribution caused by infection with pathogenic spirochetes of the genus Leptospira. Bacterial adherence to host cells is considered a crucial step in leptospiral infection and dissemination. However, the role of host-specific cellular interactions in disease outcome remains poorly understood. In this study, the adherence of pathogenic Leptospira interrogans serovar Manilae strain L495 and saprophytic Leptospira biflexa serovar Patoc I to kidney epithelial cell lines was investigated. The differing cell lines modeled reservoir, subclinical and acute disease hosts. Infection of rat kidney (RK3E), mouse kidney (TCMK-1), and hamster kidney cells (HaK) were evaluated …

Validation Of A Real-Time Pcr Laboratory Developed Test For The Detection Of Pneumocystis Jirovecii In Bronchoalveolar Lavage Samples, Caitlyn Moon

Honors Scholar Theses

Pneumocystis jirovecii is an opportunistic, host-obligate fungal pathogen responsible for causing P. jirovecii pneumonia (PJP) in humans. PJP is treated with trimethoprim-sulfamethoxazole (TMP-SMX), a strong broad-spectrum antibiotic that carries risk of renal and hepatotoxicity. Therefore, rapid diagnosis or exclusion of PJP is crucial to ensure PJP-positive patients receive effective treatment and PJP-negative patients avoid unnecessary antibiotics. Unlike most microorganisms, P. jirovecii cannot be cultured, presenting complications for the typical methods of diagnosing fungal pathogens. Historically, the gold standard for diagnosis was direct microscopic examination with stains such as methenamine silver and calcofluor white, but this diagnostic technique requires highly skilled …

Identifying And Quantifying The Presence And Benefits Of Natural Products In Commonly Consumed Herbs, Fruits, And Teas, Angelica Velasquez

Honors Scholar Theses

Natural products are primary or secondary metabolites derived from plants, animals, or microorganisms that display bioactive properties which can be beneficial to human health. Such properties include antibiotic, anticancer, antioxidant, anti-inflammatory, and may play a role in drug discovery. These compounds can be isolated and synthetically altered to enhance their therapeutic potential. However, isolating individual compounds from natural sources is often challenging due to their low abundances. Gas chromatography-mass spectrometry (GC-MS) enables the detection of trace-level metabolites, making it an indispensable tool in the screening process. In this study, GC-MS was utilized to identify and quantify natural compounds in 12 …

Health And Care: Childhood Among The Classic Period Maya At Buenavista Del Cayo, Belize, Lindsey Hall

Electronic Theses and Dissertations

Three deposits of perinates, infants, and young children within two non-residential superstructures of Buenavista del Cayo, Belize, display evidence of daily maintenance and care. A total of ten subadult individuals, aged 39.4 weeks gestation to 3 years, from the archaeological site of Buenavista were recovered during 2018 excavations. Signs of care and daily maintenance include survivorship through the vulnerable neonatal period (first twenty-eight days) and transition into infancy, survivorship with potential pinprick lesions on external and internal zygomatic, parietal, and pars basilaris, and intentional maintenance of the body after death. Identification of care and daily maintenance at Buenavista informs the …

Examining The Relationship Between Co-Curricular Programming And Burnout Among Medical Students At An Academic Medical Center, Lauren Williams

Electronic Theses and Dissertations

This three-manuscript dissertation examines the relationship between co-curricular programming and burnout among Doctor of Medicine (MD) students at the University of Mississippi Medical Center (UMMC), situating the issue within broader concerns about physician well-being and institutional responsibility.

Manuscript I establishes the conceptual and empirical foundation for the study by reviewing the prevalence, consequences, and theoretical framing of burnout in medical education. Drawing on Maslach’s three-dimensional model of burnout—emotional exhaustion, depersonalization, and reduced personal accomplishment—and Astin’s Student Involvement Theory, the manuscript situates co-curricular engagement as a potential protective factor against distress. The literature review highlights alarming rates of depression, suicidal ideation, …

Development And Evaluation Of Ros-Responsive Thioketal-Capped Mesoporous Silica Nanoparticles For Dual Drug Delivery Of Moxifloxacin And Curcumin In Wound Healing, Saiganesh Pothuraju

Electronic Theses and Dissertations

Chronic infected wounds remain a major clinical challenge because elevated reactive oxygen species (ROS) in the wound microenvironment sustain inflammation, damage regenerating tissue, and limit the effectiveness of conventional antimicrobial and anti-inflammatory therapy. To address this problem, this study aimed to develop ROS-responsive thioketal-capped mesoporous silica nanoparticles (TK-MSNs) for the dual delivery of moxifloxacin (MOX) and curcumin (CUR) to support the management of infected wounds. Mesoporous silica nanoparticles (MSNs) were synthesised using tetraethyl orthosilicate (TEOS) and cetyltrimethylammonium bromide (CTAB), followed by template removal, amino-functionalization with 3-aminopropyltriethoxysilane (APTES), and sequential loading of MOX and CUR. ROS-responsive capping was then achieved using …

Open For Victims, Sorry We're Dead, Sela Ricketts

Electronic Theses and Dissertations

This thesis is a documentary exploration of paranormal tourism in the French Quarter neighborhood of New Orleans. As of completing this project, paranormal tourism is relatively new to the city, starting in earnest in the late 1990s and early 2000s. This niche industry has woven itself into the larger New Orleans tourism industry and drastically changed the landscape and popular identity of the French Quarter. The photos give a personal perspective of how the industry manifested within the city.

The throughline of this project is a feedback loop I identified- a cycle of influences that has ultimately made the French …

Voices From The Classroom: Elementary Teachers’ Perspectives On Teaching And Learning During The Covid-19 Pandemic – A Case Study And Autoethnography, Alicia Lopez-Hernandez

Theses and Dissertations

Guided by constructivist learning theory and sociocultural theory, this qualitative case study and autoethnography examines how bilingual educators constructed knowledge, adapted instructional practices, and utilized mediational tools within face-to-face, online and hybrid learning environments. These frameworks informed the study’s design, data analysis, and interpretation of findings related to pedagogy, technology integration, and student engagement. Data was collected through semi-structured interviews, naturalistic observations, and autoethnographic reflective journaling.

The Impact Of Nutrition On Insecticide Resistance And Gene Expression In Aedes Aegypti, Esmeralda Guadalupe Rosas

Theses and Dissertations

The development of insecticide resistance in Aedes aegypti, a major vector of dengue and Zika viruses, threatens vector control efforts, particularly in endemic regions such as South Texas. Insecticides remain widely used; however, their overuse has accelerated metabolic resistance mediated by cytochrome P450 enzymes. Environmental factors such as larval nutrition may influence mosquito physiology and resistance-associated gene expression, yet this relationship remains poorly understood. This study examines how larval nutritional conditions affect the expression of cytochrome P450 genes linked to pyrethroid resistance in Aedes aegypti. Larvae were reared under five dietary treatments differing in lipid and protein ratios, and adults …

Hidden Workload In Emergency Medicine: Examining The Role Of Outside-Of-Shift Duties In Emergency Physician Fatigue, Sarah Meyer

All Theses

Emergency physicians (EPs) face high rates of burnout. In addition to well-known stressors, such as fatiguing shift work schedules and intense emotional and cognitive demands faced during clinical shifts, many EPs must also attend to certain outside-of-shift duties (OSDs)–extra-clinical role responsibilities that are expected but not always formally tracked or compensated. These duties often occur during times when EPs are expected to rest and recover from shift work. Despite concerns surrounding burnout in emergency medicine and beliefs among EPs that OSDs contribute to burnout, the effects of OSDs have rarely been studied. Using daily and weekly surveys across 28 days, …

Stochastic Universal Differential Equations For Epidemiological Modeling: Uncertainty Quantification In Disease Transmission Dynamics, Alice Menaya Armah-Bonney

Electronic Theses and Dissertations

Epidemic forecasting requires not only predictions of expected case counts, but also quantification of uncertainty, although existing surrogate modeling frameworks for agent-based models remain fundamentally deterministic. In this thesis a Stochastic Universal Differential Equation framework is presented that extends the deterministic Universal Differential Equation approach by incorporating a learnable stochastic diffusion term, enabling calibrated probabilistic forecasts while preserving the mechanistic interpretability and computational efficiency of the deterministic baseline. In doing so, a two-phase training algorithm is introduced to ensure stable convergence and the framework is validated against the ensemble output from ExaEpi, an exascale agent-based model of a COVID-19 outbreak …

Pertussis, Children's Mercy Kansas City

Clinical Pathways

No abstract provided.

Arrest Rates And Police Presence In East Bay Area Counties Of Northern California, Christiana M. Tyler

Electronic Theses, Projects, and Dissertations

In this research study, we discuss the social phenomenon of mass incarceration in the United States. Previous research has evidenced clear racial disparities within this social issue, but has yet to make a connection between high incarceration rates and the sheer volume of police officers in many communities. This descriptive study sets out to discover whether there is a difference in incarceration rates based on the level of police presence in select counties in Northern California. The study will measure police presence by the number of police officers, using secondary data from U.S. government and nonprofit agencies. The researcher hypothesizes …

Sepsis As An Immune Continuum: Cytokine Storm To Lymphopenia And Pics, Chelsey King

Senior Honors Theses

Sepsis is a leading cause of morbidity and mortality worldwide, driven by a dynamic immune continuum that progresses from early hyperinflammation to profound immunosuppression. This review examines the three overlapping phases of sepsis: the inflammation-mediated cytokine storm driven by dysregulated PRR activation, NF-κB signaling, and NETosis; apoptosis-driven lymphopenia involving caspase-mediated lymphocyte death, dendritic cell dysfunction, and metabolic exhaustion; and prolonged immunoparalysis culminating in persistent inflammation, immunosuppression, and catabolism syndrome (PICS). Key mechanisms linking these phases, including the co-existence of hyper- and hypo-inflammatory states, are synthesized alongside relevant clinical biomarkers such as IL-6, HLA-DR, and single-cell immune profiles. This review highlights …

Beyond Health Reform: The Aca And The Social Drivers Of Health, Wendy E. Parmet, Jasmine M. Howard

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

A Tractable Nematode Model For The Emerging Fungal Pathogen, Candida Auris, Melissa Martinez

Dissertations and Theses (Open Access)

Candida auris is an emerging multidrug-resistant opportunistic fungal pathogen. It

poses a significant threat to immunocompromised patients and those with prolonged stays in

healthcare facilities. C. auris spreads rapidly in health care facilities through enhanced

colonization of skin and abiotic surfaces. The genetic factors contributing to this ability and to

the virulence, drug resistance, and stress-tolerant nature of C. auris are largely unknown.

Current animal models of C. auris infections are not well standardized and report conflicting

results. Additional animal models of virulence are needed, especially those amenable to high-

throughput analysis. The nematode Caenorhabditis elegans has been validated as …

Characterization Of Staphylococcus Aureus Clinical Isolates From Deep Musculoskeletal Infections For An In Vitro Biofilm Model For Phage Therapy, Raquel C. Luna

Dissertations and Theses (Open Access)

The rise of multidrug-resistant (MDR) infections is a growing concern in the treatment of deep musculoskeletal infections (MSKIs) and orthopaedic device-related infections (ODRIs). Staphylococcus aureus is responsible for about one third of these infections due to its strong biofilm forming capacity, presence on human skin, and the large number of antibiotic-resistant variants. Bacteriophage (phage) therapy is now being considered as a treatment for MDR MSKIs/ODRIs. We are investigating the use of phage encapsulated into or adsorbed onto biodegradable microspheres for local delivery to the site of these MDR infections. We determined that the anti-staphylococcal phage K effectively lyses the S. …

From Antigen Presentation To Tumor Control: Mechanisms Of Type I Conventional Dendritic Cell-Based Cancer Vaccines, Josue E. Pineda

Dissertations and Theses (Open Access)

Type 1 conventional dendritic cells (cDC1s) are important for generating and sustaining antitumor immunity. Accordingly, the abundance of cDC1s in human tumors correlates with improved outcomes in cancer. Capitalizing on this role, we previously demonstrated that vaccination with in vitro-derived murine cDC1s elicits durable tumor control in multiple preclinical models; however, the immunological mechanisms underlying the efficacy of cDC1 vaccination remain unclear. Here, we examined whether in vitro-derived cDC1s resemble tumor-infiltrating DC populations and whether MHC-I and MHC-II antigen presentation contribute to cDC1-mediated tumor control following vaccination in melanoma.

As expected, MHC-I- or MHC-II-deficiency had minimal impact on …

Understanding Epigenomic Landscapes In Cancer Progression And Immunotherapy Response, Jonathan Schulz

Dissertations and Theses (Open Access)

Nonmutational epigenomic reprogramming has emerged as a key hallmark of cancer that plays crucial roles in tumor evolution during its progression and response to therapy. However, the extent and nature of epigenomic reprogramming remains poorly understood. This dissertation examines how epigenetic regulation shapes cancer progression and response to immunotherapy. Working at the intersection of cancer biology and computational genomics, it develops analytical frameworks for characterizing chromatin structure and DNA methylation across diverse tumor contexts and uses these frameworks to address two complementary biological questions: how promoter-associated chromatin organization varies across cancer types, and how epigenetic perturbation modulates tumor immunogenicity in …

An Integrated Framework For Early Detection And Transmissibility Assessment Of Emerging Variants In Wastewater, Xingwen Chen, Tin Phan, Wei Lin Lee, Katie Clark, Steven F Rhode, Samantha Brozak, Bruce Pell, Tsultrim Palden, Mats Leifels, Anna Gitter, Yang Kuang, Stefan Wuertz, Janelle Thompson, Kristina D Mena, Eric J Alm, Fuqing Wu

Faculty, Staff and Student Publications

Tracking the emergence of new viral variants is critical for epidemic preparedness, but remains challenging because variants typically circulate at low prevalence during the early phase of outbreaks. Here, we present an integrated framework that combines sensitive variant detection in wastewater with quantitative assessment of transmissibility through dynamic epidemic modeling. Using the SARS-CoV-2 Omicron variant as a proof of concept, we developed a novel nested allele-specific RT-qPCR assay (NAS-PCR) that achieved a thousand-fold increase in sensitivity compared with allele-specific RT-qPCR (limit of detection: 0.5 copies/μl). NAS-PCR detected Omicron in wastewater samples from the Greater Boston area starting in September 2021, …

Identifying And Exploring The Presence Of Antibiotic Resistant Escherichia Coli In Private Groundwater Sources In Southeastern Ontario Via Machine Learning, Madeleine Kelly, Paul Hynds, R. Stephen Brown, Kevin Mcdermott, Ioan Petculescu, Rhiannon Punch, Anna Majury

Research Outputs: 2025-Present

According to the World Health Organization, antibiotic resistance represents one of the top global public health and development threats. The environment serves as a significant reservoir and transmission pathway for antibiotic-resistant bacteria (ARB), with anthropogenic activities introducing resistant bacteria, resistance genes, and antibiotic residues to soils and aquatic systems, thereby promoting development and dissemination of resistance. Groundwater has recently been highlighted as an important reservoir for antibiotic-resistant bacteria, with over four million Canadian residents currently relying on private groundwater wells (Statistics Canada, 2024). While groundwater is increasingly acknowledged as a reservoir of ARB, the influence of external drivers affecting their …

Abnormal Trafficking And Processing Of Multiple Matrix Metalloproteinases Drive Cartilage Defects In Congenital Disorders Of Glycosylation, Chia-Lun Wu

All Dissertations

Congenital Disorders of Glycosylation (CDG) are rare metabolic diseases caused by defects in glycosylation. Despite identification of over 200 CDG types, the mechanisms linking glycosylation defects to diverse clinical phenotypes remain unclear. This dissertation uses zebrafish models of PMM2-CDG and STT3-CDG to redefine CDG pathogenesis, shifting from a simple glycan deficiency model to one involving disrupted cellular spatial organization.

We identify a protease-dependent pathway underlying craniofacial cartilage defects. Specifically, defective proteolytic processing of N-cadherin, a key adhesion molecule in chondrogenesis, is a central driver of pathology. We further uncover an unconventional trafficking mechanism in which ER stress and altered secretory …

Enhancing Food Security In Stann Creek, Belize Using Meat Rabbits: Engineering Perspective, Lindsey Garretson

Biological and Agricultural Engineering Undergraduate Honors Theses

The purpose of this paper is to discuss the engineering perspective within the overall project of using meat rabbits to enhance food security and nutrition within Stann Creek, Belize. From the engineering perspective, the overarching goals were like the overarching project goals including the construction and materials required guide within the manual, designing potential upgrades to the design including a solar and battery system and an automatic watering system, and to design the system to be “practically sustainable” where possible. The constraints for this project included cost, the size of land dedicated for the rabbitry, and the operational and environmental …

A Mass Disabling Event: Why California Courts Must Protect Workers’ Families From Take-Home Covid, Ellery Armstrong

Seattle Journal for Social Justice

No abstract provided.

Understanding The Role Of Toxs As A Bile Sensing Component Of The Toxrs Virulence Regulatory System In Vibrio Spp., Minje Kim

Dartmouth College Ph.D Dissertations

Pathogenic Vibrio bacteria, such as V. cholerae and V. parahaemolyticus, colonize in the human small intestine to cause severe gastrointestinal disease. During the infection, these bacteria encounter bile salts, antimicrobial cholesterol metabolites secreted into the intestine. Pathogenic Vibrio species have evolved to utilize bile salts as signals to regulate virulence. The signaling depends in part on ToxRS, a conserved co-component transmembrane transcription regulator. ToxRS consists of the transcription factor ToxR and its membrane-tethered binding partner ToxS. ToxS is required for ToxR stability and full transcriptional activity. Although bile salts are known to influence ToxRS-dependent virulence gene expression, the molecular …

Drug Repurposing Against Giardia Targeting Lipid Rafts, Extracellular Vesicles, And Sphingolipid Synthesis, Breanna Chantal Pence

Open Access Theses & Dissertations

Giardia lamblia is a protozoan parasite responsible for the intestinal disease giardiasis worldwide. Giardia is one of the major intestinal parasites in the world, with over 500,000 new cases annually. Symptoms of giardiasis include diarrhea, abdominal pain, and nausea. Children are particularly vulnerable to giardiasis, with cases of malnutrition, stunted growth, and cognitive impairment in countries where the disease is endemic. Giardia consists of two morphologic forms: an infective cyst which transmits the disease and a motile trophozoite which attaches to the epithelium of the small intestine during infection. Metronidazole is a common treatment for giardiasis, but cases of toxicity …