Digital Commons Network^™

Shark Immunology And Its Biomedical Potential: Evolution, Innovation, And The Imperative Of Conservation, Reesha Bhagat

Undergraduate Honors Thesis Collection

This review aims to shed light on a significant ecological deficit and its implications for the future of science and medicine. Sharks possess a uniquely adaptive, cancer-resistant, and evolutionarily refined immune system with transformative biomedical potential, making their conservation a scientific and medical imperative. We are losing something medically irreplaceable, and we don’t even fully understand it yet. Shark conservation is a pressing scientific imperative because sharks are ecologically essential and represent an irreplaceable biomedical resource.

The Effects Of Heat Stress On White Blood Cell Profiles And Antibody Concentrations In Broilers Genetically Selected For Low Water Conversion Ratio Compared To The Modern Random Bred Broiler, Luke B. Janski

Poultry Science Undergraduate Honors Theses

Heat stress (HS) is one of the most significant environmental stressors impacting poultry production worldwide, reducing growth, feed efficiency, welfare, and immune competence. With global temperatures rising, understanding physiological and immunological adaptations to HS is essential for sustainable production. Broiler chickens selectively bred for low water conversion ratio (LWCR) have shown potential for reduced water consumption under environmental challenges; however, their immune resilience under HS conditions compared with modern random-bred (MRB) broilers remains unclear. This study investigated the effects of cyclic HS on red- (RBC) and white- (WBC) blood cells and humoral immunity in LWCR and MRB broilers. Birds were …

Permit Management Guide For Sanitation Projects In Rural Alaska, Cooper Arend

Student Projects for Graduate Degrees

This project examines the permitting management process currently used for rural sanitation infrastructure projects executed by the Alaska Native Tribal Health Consortium (ANTHC) Division of Environmental Health and Engineering (DEHE). These projects are large-scale, federally funded projects requiring numerous permits from federal, state and local agencies with varying requirements and timelines. Despite this complexity, the permitting process relies heavily on informal, experience-based knowledge rather than any formal documentation. A qualitative research approach was used to examine the existing ANTHC workflows, review past project documentation, analyze regulatory materials, and incorporate staff interviews and feedback. Findings from this project indicated that while …

Exploring Google Trends In Assessing Personal Finance Needs For Cooperative Extension Service Programming, Megan Wells

Graduate Theses and Dissertations

The Cooperative Extension Service (CES) relies on systematic needs assessments to guide program development; yet, traditional approaches often depend heavily on stakeholder input and professional judgment, offering limited insight into consumer level needs. This mixed methods study explored Google Trends as a complementary, consumer driven data source for assessing Family Resource Management (FRM) needs within the Arkansas CES. Grounded in Witkin and Altschuld’s three level needs assessment framework and Uses and Gratifications Theory, the study integrated three data sources representing stakeholders, service providers, and consumers: (1) Family and Consumer Sciences (FCS) advisory committee reports, (2) survey of Family Consumer Science …

Is Design A Form Of Caregiving?, Sidney Jordan

Interior Design Capstones

This thesis challenges the traditional hierarchy of clinical architecture, which historically prioritizes patient outcomes while overlooking the practitioner’s human experience. By investigating whether environmental design can act as a form of caregiving, this research addresses the critical gap between the physiological demands of healthcare labor and the holistic needs of the people performing it. The project argues that burnout is not just a result of high-stakes medicine, but is actively produced by physical layouts and a workplace culture that treats providers as parts of a machine rather than valued individuals. The methodological framework utilizes a tri-layered approach to bridge the …

Through The Lens Of Zoology, Madalyn Haun

Interior Design Capstones

Current zoo and sanctuary models often fail to meet the complex psychological, behavioral, and spatial needs of endangered and rehabilitated wildlife, resulting in chronic stress and welfare compromises. Beyond the Cage presents a transformation approach to zoological design, shifting the paradigm from entertainment-based displays to a “welfare-first” philosophy. This book argues that effective captive care requires expansive, species-appropriate habitats that facilitate natural behaviors, rather than merely simulating natural aesthetics. Through the lens of modern zoology, this work explores the implementation of groundbreaking exhibit re-creation, focusing on habitat enlargement, precise climate change control, and innovative environmental enrichment. A central pillar of …

Promoting Influenza Vaccination Among College Students, Wajeeha Khan Valley

Electronic Theses, Projects, and Dissertations

Influenza remains a significant public health concern on college campuses, where high population density, shared living environments, and frequent social interaction increase the risk of viral transmission. Despite the availability of safe and effective influenza vaccines, vaccination rates among college-aged students remain consistently low. Many students underestimate their personal risk for influenza and hold persistent misconceptions regarding vaccine safety, effectiveness, and side effects. The widespread use of social media further influences these attitudes, as misinformation can rapidly spread while credible health messaging often struggles to gain visibility. It is important to eliminate vaccine hesitancy among college students through innovative, behavior-focused …

Determinants Of Hypertension Awareness And Control In Kenya: A Secondary Analysis Of National Survey Data, Alexander K. Davis

Honors Theses

In low- and middle-income countries (LMICs), cardiovascular diseases (CVDs) are prevalent and pose a major concern as the current healthcare systems are oriented primarily towards communicable diseases. The largest contributor to CVDs, hypertension, is a significant issue in Kenya, a model LMIC. Based on previous studies in this lab, high rates of hypertension are present in the region of Kasigau, Kenya. Kasigau is a small region within Taita-Taveta County, Kenya. Traditional risk factors are not necessarily predictive of hypertension in all regions of Kenya. This study aims to address the lack of tested risk factors for hypertension in Kenya and …

Enhancing Food Security In Stann Creek. Belize Using Meat Rabbits, Lindsey Garretson

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

In recent years, food insecurity and the prevalence of hunger have rapidly grown throughout the world, but especially within Latin America and the Caribbean. Along with growing rates of food insecurity and hunger there are increases in medical conditions including negative impacts the functioning of every major organ system, increased rates of mental illness, both overweight and underweight children, wasting in both children and adults, and anemia. Availability and access to healthy, nutritional food options can help lower the risk of these conditions. With these considerations, the goal of this project was to create an all-encompassing manual and construction guide …

Avoiding Pathogens Or Avoiding People? Pathogen Avoidance, Pathogen-Specific Stereotypes, And Intergroup Bias Toward South Asians, Aashvi Dahiya

Psychological Science Undergraduate Honors Theses

People are motivated to avoid pathogens because infection poses serious risks (e.g., illness, death). Pathogen avoidance often relies on indirect cues and stereotypes—like appearance or group membership—to identify potential pathogen threats. A large body of literature has linked pathogen avoidance to intergroup bias, but recent work suggests that this link may vary across social groups. In particular, pathogen avoidance may be more strongly associated with intergroup bias toward groups specifically linked to pathogen-specific stereotypes. The present study examined whether pathogen-specific stereotype endorsement moderates the relationship between pathogen avoidance and intergroup bias toward South Asians. A sample of 684 participants completed …

Clinical And Demographic Characteristics Of Hospitalized Patients With Xylazine-Related Wounds, Elizabeth Novick, Nikhil Seval, Dagan Coppock, Mollie Tucker, Daniel Taupin, John Zurlo, Carolyn Kramer

Department of Medicine Faculty Papers

OBJECTIVES: Little is known about the demographic and clinical features of patients with xylazine-related wounds. We sought to characterize hospitalized patients with substance use disorder (SUD) and xylazine-related wounds seen for infectious diseases consultation.

METHODS: We retrospectively reviewed the medical records of 193 patients diagnosed with SUD at 3 Philadelphia hospitals between October 2023 and January 2024. Patients were identified as either being diagnosed with (n=73) or without (n=120) xylazine-related wounds. We compared the demographic and clinical features between the 2 groups.

RESULTS: Patients diagnosed with wounds were younger ( P < 0.001), more likely to be White or Hispanic and less likely to be Black/AA ( P < 0.001), more likely to have tested positive for fentanyl ( P < 0.001), amphetamines ( P < 0.001), and cocaine ( P 0.001), more likely to acknowledge injection ( P < 0.001), and more likely to leave the hospital by patient-directed discharge (PDD) ( P < 0.001). Most patients had multiple wounds (75%), and more than half (53%) had at least one wound greater than 10 cm at its widest dimension. Although most patients diagnosed with wounds received antibiotics, many did not have symptoms or signs of infection.

CONCLUSIONS: Xylazine-related wounds are highly associated with illicitly manufactured …

Climate Lies And Unjust Profits, Vanessa Casado-Pérez, Yotam Kaplan, Yael Lifshitz, Niv Meyerson

Faculty Scholarship

The climate crisis has reached a perilous tipping point. Our entrenched reliance on fossil fuels remains unchecked, as fossil fuel corporations wield their power to block meaningful reform and entrench their profits. The political horizon offers little relief—an incoming administration is poised to dismantle vital environmental protections, stripping away the few safeguards that stand between us and climate catastrophe.

In this grim landscape, communities across the nation are turning to the courts with renewed urgency, seeking justice and reform through climate litigation. Yet past efforts have fallen short, stymied by two formidable barriers. First, by centering on greenhouse gas emissions …

Genome-Wide Phenotypic Characterization Of Mycobacteriophage Mercurio, Tyler Downs

Departmental Honors & Graduate Capstone Projects

Bacteriophages, or phages, are being piloted as a supplemental or alternative therapeutic to antibiotics against drug-resistant Mycobacterium pathogens, such as M. tuberculosis, which pose a global public health crisis.  Characterizing bacteriophage genomes can provide insights into efficacy in phage therapy before implementation or elucidate new targets to manipulate bacterial growth.  Overexpression of individual phage genes is useful to study a gene product’s function independent of others.  Here, the results of phage Mercurio plasmid library overexpression in plate-based assays are described.  Mercurio infects nonpathogenic Mycobacterium smegmatis and is genetically related to bacteriophages infecting pathogenic Mycobacterium species.  Eleven gene products of …

Barriers To Climate Change And Sustainability Action: Nursing Education And Practice, Dawn Marie Smith

Dissertations

Climate change is one of the most pressing public health emergencies of our time and nurses can have a great impact in their current practice and in the education of future nurses (The Alliance of Nurses for Healthy Environments, n.d.; American Nurses Association, 2023; Health Care without Harm, 2025). Deaths due to rising temperatures, vector-borne illness, and food insecurity related to drought and extreme weather are on the rise (WHO, 2024). It has been estimated that globally over 250,000 additional deaths will be attributed to climate related effects between 2030 and 2050 (Watts et al., 2020; WHO, 2023).

A primary …

Promises, Pitfalls, And Paths Forward For The Pediatric Research Equity Act., Alexa L. Pagano, Danielle J. Green, Jennifer Goldman, Anjali Deshmukh

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Since its enactment in 2003, the Pediatric Research Equity Act (PREA) has significantly increased the number of pediatric drug studies performed and expanded pediatric drug labeling. Despite these advancements, many drugs used in children still lack pediatric-specific US Food and Drug Administration (FDA) labeling, even when pediatric studies are required by law. Recent legislative changes strengthened the FDA's enforcement authority over PREA. As these changes are implemented, persistent gaps in pediatric drug development warrant examination. Addressing these gaps may help ensure that children are systematically included in clinical research and that medications used in children are supported by rigorous …

Natural Maternal Immunity Protects Neonates From Escherichia Coli Sepsis., Raymond E. Diep, Ujjwal Adhikari, Kubra Gokce Tezel, Giang Pham, Allison R. Burrell, Mary A. Staat, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Kate M. Peters, Mark A. Schembri, Scott H. Saunders, David B. Haslam, John J. Erickson, Susana Chavez-Bueno, Sing Sing Way

Manuscripts, Articles, Book Chapters and Other Papers

Escherichia coli is a leading cause of neonatal sepsis, with infection occurring in approximately one in every 1,000 live births. However, with E. coli colonization beginning soon after birth and defects in neonatal host defence maturation, an alternative consideration is why infection does not occur even more frequently. Here we show that newborn babies with E. coli sepsis have selectively reduced vertically transferred natural antibodies that recognize E. coli, mechanistically explaining their susceptibility to infection. Complementary preclinical studies show that preconceptual intestinal colonization with probiotic E. coli Nissle 1917 (EcN) primes anti-E. coli immunoglobulin G (IgG) antibodies with broad cross-reactivity …

Clinical Characteristics, Antibiotic Resistance Trends, And Associated Molecular Epidemiology Traits In Escherichia Coli Isolates Producing Neonatal Bacteremia, Keerti Ivaturi, Christine Symes, Mina Farahbakhsh, Sanjula Bhuri, Joshua L Wheatley, Rangaraj Selvarangan, Daniel P. Heruth, Susana Chavez-Bueno

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Escherichia coli is a leading cause of neonatal sepsis. This study's objective was to investigate the clinical characteristics of newborns with E. coli bacteremia, and recent antibiotic resistance trends and molecular epidemiologic features of these invasive strains.

METHODS: Clinical data and blood E. coli isolates collected from 54 neonates with bacteremia were studied. E. coli antibiotic susceptibility trends over time, and whole-genome sequencing data relevant to the genomic relatedness and capsule genotype of the isolates were analyzed.

RESULTS: Thirty percent of bacteremic newborns were preterm. Mortality was 19% in preterm versus 5% in term infants. Cerebrospinal fluid was collected …

The Environment, Health, And Vector Nexus: Evaluating The Spatiotemporal Variability And Societal Impact Of Ticks In Arkansas, Dalton Williams

Graduate Theses and Dissertations

Tick-borne diseases (TBDs) are a surging public health and veterinary concern in the United States. In states like Arkansas, climate change and shifting land use have recalibrated the ecological niches of vector species. This research utilizes species distribution and ecological niche modeling to assess the spatiotemporal suitability of ixodid tick habitats, specifically where environmental and socioeconomic factors intersect. By integrating spatial science with public health frameworks, this study identifies priority intervention areas in underserved rural regions where healthcare resources are often constrained. This study provides a comprehensive methodological framework, leveraging remote sensing datasets and historic disease data to delineate exposure …

Data And Big Data, Rebecca Kyser

Surviving the Stacks Comic

No abstract provided.

Barriers And Facilitators Of Childhood Immunization: A Mixed Methods Assessment Of Health Care And Community Health Professionals’ Observations, Jenny Dong

Theses/Capstones/Creative Projects

Childhood immunization has led to significant decreases in the burden of infectious disease morbidity and mortality. Despite these contributions, U.S. childhood vaccination rates have been declining in recent years, and updates to the federal immunization schedule have removed recommendations for several childhood vaccinations. Amid such an uncertain public health landscape, understanding how environmental conditions affect childhood immunization behaviors is crucial for ensuring that children receive the vital protections vaccines offer. Thus, the purpose of this study is to examine the barriers and facilitators of childhood immunization observed by Nebraska health care professionals (HCPs). This study utilized an online questionnaire and …

A Formal Clinical Reasoning Curriculum And Clinical Reasoning Case Conference For The Internal Medicine Residency Program, Edward Pilkington Md

Academy Scholars Projects

Through the support of the MITE Academy Scholars Program and the Maine Medical Center Department of Medicine a formal clinical reasoning curriculum and Clinical Reasoning Case Conference has been developed and successfully integrated into the MMC Internal Medicine Residency Program’s didactic programming.

Edvard Munch And The Feminine Sublime, Saralyn Goodspeed

Theses

This paper explores the theory of the sublime in relation to Edvard Munch’s depictions of women. Departing from the common view that Munch was simply anxious about the “New Woman” that emerged in the late nineteenth-century, I argue that Munch’s conflicting emotions regarding women were sublime in nature, rooted in his childhood relationship with his mother. A formal analysis is conducted on three of Munch’s works: Inheritance (1897), Three Stages of Woman or Sphinx (1894), and Madonna (1895). These analyses link Munch’s representations of women to a maternal sublime.

Antimicrobial Activity Of Sulbactam-Durlobactam Against Acinetobacter Baumannii-Calcoaceticus Complex Strains Causing Non-Respiratory And Non-Bloodstream Infections From The United States (2023–2025), Erik Munson

Clinical Lab Sciences Faculty Research and Publications

Acinetobacter baumannii most often causes pneumonia in critically ill patients. However, A. baumannii is also an important cause of a broader range of infections, including skin/wound and urinary tract infections. This study aims to evaluate the in vitro activity of sulbactam-durlobactam and comparator antibiotics, including meropenem and cefiderocol against A. baumannii-calcoaceticus complex isolates from non-respiratory and non-bloodstream sources. Samples included 285 A. baumannii-calcoaceticus complex isolates enriched for carbapenem resistance collected across 17 states in the United States (January 2023–May 2025). Antimicrobial susceptibility tests were conducted by manual broth microdilution and interpreted according to Clinical and Laboratory Standards Institute (CLSI) and …

The Evaluation Of Immune Dysregulation Detection In Individuals With Psychiatric Conditions, Alyssa Kiel

Theses & ETDs

32 studies were evaluated in determining detection of immune dysregulation, derived from monocyte, T-cell, B-cell, and protein panels, and identifying trends in disorder-specific biomarker data for different psychiatric conditions including, ASD, schizophrenia, MDD, bipolar disorder, GAD, OCD, ADHD, and C-PTSD. The studies selected reporting significant immune abnormalities from biomarker data, with observed findings of immune dysregulation in psychiatric populations frequently coincided with the prevalence of comorbid physical issues, such as metabolic imbalances, cardiovascular conditions, and gastrointestinal issues. These observations highlight the intersection of altered biomarker variation and comorbid disease outcomes present in individuals (including their sex) with psychiatric conditions compared …

Gme As A Healthcare And Economic Driver In Southern Nevada, Tripp Umbach

Policy Briefs and Reports

In early 2025, the Nevada Health and Bioscience Corporation (NHBC) commissioned Tripp Umbach to conduct a comprehensive study examining the current state and future expansion of physician training and retention in Southern Nevada. The approach recommended in this report is rooted in strategic partnerships among medical institutions, proven funding approaches, and needed policy changes. Tripp Umbach, a nationally renowned private consultancy specializing in medical education expansion strategies, reviewed data, conducted interviews, and developed recommendations to expand GME, highlighting its profound economic impact in Southern Nevada.

Environmental Awareness And Community Sentiments In A Superfund Site: A Study Of South Chattanooga, Mia Dial

Honors Theses

The concept of environmental injustice refers to the disproportionate exposure of marginalized communities to environmental hazards, often resulting from the placement of industrial sites, waste facilities, or other environmentally harmful infrastructure in areas with limited political and economic power. Alton Park, a historically underserved neighborhood in Chattanooga, Tennessee, faces elevated environmental risks due to its proximity to the South Chattanooga Lead Superfund Site and legacy industrial contamination. This study used semi-structured individual interviews to assess community awareness, perceptions, and behaviors related to environmental hazards in Alton Park. Residents generally reported some awareness of the Superfund site, though knowledge was often …

Integrating Growth Performance And Pathogen Detection To Investigate Disease Resilience In Commercial Swine, Emmalise Hope Marie Meyer

Department of Animal Science: Dissertations, Theses, and Student Research

Disease resilience is an important trait in commercial swine production, influencing both animal health and growth performance under natural disease challenge. The primary objective of this study was to integrate growth performance data with longitudinal pathogen detection to better understand factors contributing to disease resilience in commercial pigs. A population of 1,014 pigs across four batches was monitored from weaning through the grow-finish phase, with body weights collected to calculate average daily gain (ADG). Genome-wide association analyses were conducted using BayesC and BayesIM approaches to identify genomic regions associated with growth performance. Longitudinal pathogen surveillance was performed using pen-level oral …

Empowering Women Journalists’ Preparedness: An Evaluation Of Hostile Environment First Aid Training (Hefat) And Its Implementation In Academic Journalism Programs, Vanessa Charlot

Electronic Theses and Dissertations

This Dissertation in Practice examines the potential integration of gender-sensitive Hostile Environment and First Aid Training (HEFAT) into journalism education to enhance the preparedness of women journalists for high-risk reporting contexts. Manuscript I investigates existing gaps in curricula, highlighting the distinct physical, psychological, and ethical risks encountered by women in hostile environments. Manuscript II outlines a framework for qualitatively evaluating an adapted HEFAT program, considering how identity-informed and trauma-sensitive approaches might strengthen student safety, resilience, and ethical decision-making. Manuscript III explores leadership strategies for implementing inclusive, trauma-informed HEFAT curricula, emphasizing reflexive practice and self-authorship as mechanisms for fostering transformative, equity-driven …

The Hitchhiker's Guide To The Host: Fleas And The History Of Pikas In North America, Josh Pletcher

All NMU Master's Theses

Parasite phylogenetics can offer windows into the cryptic evolutionary history of hosts, often highlighting events that are not recorded by the phylogenetics of the host. Pikas (small lagomorphs) host a diverse parasite community comprising endoparasites (e.g., coccidians, nematodes, and cestodes) and ectoparasites (e.g., fleas and mites). Phylogenetic analysis of pika endoparasites has revealed pikas evolved in Asia and colonized North America in two waves, and that contact between these two pika lineages allowed parasites to be transferred from one lineage to another and to survive the extinction of their original host. To uncover these cryptic histories, understanding the biogeography of …

Pathogenic Leptospira Adherence To Epithelial Cells: A Comparison Between Different Hosts Based On Outcome Of Disease, Imaan G. Masood

Honors Scholar Theses

Leptospirosis is a neglected zoonotic disease with global distribution caused by infection with pathogenic spirochetes of the genus Leptospira. Bacterial adherence to host cells is considered a crucial step in leptospiral infection and dissemination. However, the role of host-specific cellular interactions in disease outcome remains poorly understood. In this study, the adherence of pathogenic Leptospira interrogans serovar Manilae strain L495 and saprophytic Leptospira biflexa serovar Patoc I to kidney epithelial cell lines was investigated. The differing cell lines modeled reservoir, subclinical and acute disease hosts. Infection of rat kidney (RK3E), mouse kidney (TCMK-1), and hamster kidney cells (HaK) were evaluated …