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Musculoskeletal Infection Reporting And Data System (Mski-Rads): Reviewed And Explained, Angela He, Flavio Duarte Silva, Mina Guirguis, Erin F. Alaia, William B Morrison, Avneesh Chhabra

Department of Radiology Faculty Papers

A standardized guideline and scoring system are recommended for the imaging evaluation of musculoskeletal infections on MR imaging. The Musculoskeletal Infection Reporting and Data System (MSKI-RADS) is a recently developed and validated classification system using MR imaging that can be used to classify the severity and extent of musculoskeletal infections, improve radiology-pathology concordance, and outline the corresponding management recommendations. This review article explains MSKI-RADS and discusses the different elements of this system in detail with a review of pertinent literature so that the readers can apply it in their practices. The work outlines the technical considerations for optimal MR imaging …

Secondary Syphilis Case Report: Septic Arthritis And Tendinopathy, Phil Kulpinski

Advocate GME

No abstract provided.

Dose-Dependent Ifn Programs In Myeloid Cells After Mrna And Adenovirus Covid-19 Vaccination., Giray N Eryilmaz, Yilmaz Yucehan Yazici, Radu Marches, Eleni P Mimitou, Lisa Kenyon-Pesce, Kim Handrejk, Sonia Jangra, Michael Schotsaert, Adolfo García-Sastre, George A Kuchel, Jacques Banchereau, Duygu Ucar

Faculty Research 2026

BACKGROUND. The SARS-CoV-2 pandemic provided a rare opportunity to study how human immune responses develop to a novel viral antigen delivered through different vaccine platforms. However, to date, no study has directly compared immune responses to all 3 FDA-approved COVID-19 vaccines at single-cell multiomic resolution.

METHODS. We longitudinally profiled SARS-CoV-2–naive adults (n = 31) vaccinated with BNT162b2, mRNA-1273, or Ad26.COV2.S, integrating plasma cytokines, antibody titers, and single-cell multiomic data (DOGMA-Seq).

RESULTS. We discovered a distinct, transient IFN program termed ISG-dim, which emerged specifically 1–2 days after the first mRNA dose in approximately 10% of myeloid cells. This state was …

A Correlation Between Leptin Hormone And Other Biochemical Parameters In Iraqi Women With Hepatitis C Virus (Hcv) In Thi-Qar Governorate In Iraq, Hadeel Rashid Faraj, Alyaa Majid, Sarah A Sayer

Baghdad Science Journal

Background: chronic hepatitis C virus (HCV) infection is a major health problem. Females of childbearing age who are infected with hepatitis C are exposed to premature aging of the ovaries, which leads to an imbalance in the levels of sex hormones leptin hormone is associated with all stages of reproductive age. The aim of the present study is to observe levels the liver enzyme, Albumin, total bilirubin, estrogen, progesterone and leptin hormone. Also to evaluate the correlation between ( leptin hormone liver enzyme, Albumin, total bilirubin, estrogen and progesterone ).Methods: Serum liver enzyme, Albumin, total bilirubin, estrogen, progesterone and leptin …

Dose-Dependent Ifn Programs In Myeloid Cells After Mrna And Adenovirus Covid-19 Vaccination., Giray N Eryilmaz, Yilmaz Yucehan Yazici, Radu Marches, Eleni P Mimitou, Lisa Kenyon-Pesce, Kim Handrejk, Sonia Jangra, Michael Schotsaert, Adolfo García-Sastre, George A Kuchel, Jacques Banchereau, Duygu Ucar

Faculty Research 2026

BACKGROUNDThe SARS-CoV-2 pandemic provided a rare opportunity to study how human immune responses develop to a novel viral antigen delivered through different vaccine platforms. However, to date, no study has directly compared immune responses to all 3 FDA-approved COVID-19 vaccines at single-cell multiomic resolution.METHODSWe longitudinally profiled SARS-CoV-2-naive adults (n = 31) vaccinated with BNT162b2, mRNA-1273, or Ad26.COV2.S, integrating plasma cytokines, antibody titers, and single-cell multiomic data (DOGMA-Seq).RESULTSWe discovered a distinct, transient IFN program termed ISG-dim, which emerged specifically 1-2 days after the first mRNA dose in approximately 10% of myeloid cells. This state was characterized by ISGF3 complex activation and …

Investigation Of Antimicrobial Synergism Of Actinomycin Derivatives From Streptomyces Parvus 35m1 Against Escherichia Coli Atcc 25922, Özge Can, Mustafa Ünver Kurt, Meli̇s Küçüksolak, Ataç Uzel, Erdal Bedi̇r

Turkish Journal of Biology

Background/aim: Limited drug development and increased antibiotic tolerance among Gram-negative bacteria have led researchers to consider combination therapy. Actinomycin derivatives, particularly actinomycin D, exhibit a wide range of bioactivities, including antibacterial effects. However, actinomycin D is less effective against Gram-negative pathogens. Therefore, it is essential to demonstrate the synergy of actinomycin D and its derivatives with clinically known antibiotics against Escherichia coli ATCC 25922 and investigate the effects on cellular morphology.

Materials and methods: Streptomyces parvus 35M1 isolated from coastal sediment in İzmir/Türkiye was identified via genome sequencing. Large-scale (30 L) fermentation followed by chromatographic purification yielded compounds 1 (actinomycin …

The Impact Of Vascular Endothelial Growth Factor, Neutrophil Gelatinase-Associated Lipocalin, And Interleukin-38 Food And Air Allergy Patients Following The Pandemic Of Covid-19 In Iraq, Esraa Hameed Khamees, Zaizafoon N. Nasif

Baghdad Science Journal

Allergies are a common health issue where the immune system reacts to substances in the environment that are normally harmless. This study further investigates the effects of vascular endothelial growth factor (VEGF), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-38 (IL-38), immunoglobulin E (IgE), and the neutrophil-lymphocyte ratio (NLR) in these individuals, offering insight into the probable processes behind allergic responses following the pandemic. The study comprised 120 non-vaccinated females with previous COVID-19 infection. Groups included controls and food and air (F&A) allergic patients, with 60 individuals matched for age and gender. Serum levels of IL-38, VEGF, IgE, and NGLA were assessed using …

A New Prospective Of Colistin Resistance Profile Of Some Staphylococcus Species Isolated From Iraqi Wound Fractured Foot, Zahraa M. Fadhil, Halah H Al-Haideri

Baghdad Science Journal

Sulbactam belongs to β-lactamase inhibitors that are more commonly used for Gram-negative bacteria than Gram-positive bacteria. In this study, nine different species of Staphylococcus (S. aureus, S. epidermidis, S.hominis, S. lentus, S. pseudintermedius, S. lugdunensis, S. haemolyticus, S. sciuri , and S. warneri. were isolated from wounded-fractured feet of Iraqi patients. The spectrum of activity of sulbactam and colistin against all isolates was evaluated. Surprisingly, among S. aureus isolates, 5 (12) isolates were sensitive to colistin, whereas, all bacterial isolates were completely resistant to sulbactam. Here, our study revealed that combining …

Navigating (M)Otherhood: Perception, Practice, & Policy Of Adolescent Pregnancy In The North Coast Of Perú, Mahir Rahman

USF Tampa Graduate Theses and Dissertations

“It’s a vicious circle”, the obstetricians of Huanchaco repeated time and time again after discussing a recently pregnant 13-year-old girl who had just moved to the North Coast of Perú. Adolescent pregnancy is an extremely stigmatized topic in global maternal and child health discourse. Pregnant adolescents are subject to educational policy, clinical protocol, and community practice. While global scholarship emphasizes adolescent pregnancy prevention, limited scholarship focuses on the conditions in which adolescent pregnancy is perceived, discussed, and managed. More importantly, these perspectives are even less documented amongst the North Coast of Perú.

This thesis serves as an ethnographic exploration of …

A Scoping Review On Governing The Commercial Determinants Of Health: Mechanisms, Tools, And Collaborative Approaches, Alyssa S. Khan, Sierra Arnold, Imran Bari, Isabel G. Long, Nino Paichadze

Student Works

Purpose: The commercial determinants of health (CDoH) are the systems, practices, and pathways through which commercial actors drive health and equity. This review aimed to identify CDoH governance approaches, distinguishing between promoted and criticized approaches.

Design/Methodology/Approach: We conducted a systematic scoping review in PubMed and Google Scholar databases. Relevant grey literature was also identified through citation searching and reference list review. Our search strategy combined terms related to economic and commercial determinants of health, governance models, and health outcomes. English-language publications between January 2000 to December 2025 were included. Relevant data from included sources were extracted and then synthesized using …

Adalimumab Therapy For Crohn’S Disease And Axial Spondyloarthritis In Latent Tuberculosis: A Bibliometric-Systematic Literature Review, Nyimas Maida Shofa, Nurike Setiyari Mudjari, Rusdiyana Ekawati, Arianti Arianti, Annisa Zahra Mufida, Budi Widodo, Titong Sugihartono

Sultan Qaboos University Medical Journal

The management of Crohn’s disease (CD) using anti-tumour necrosis factor therapy in tuberculosis (TB)-endemic regions poses major clinical challenges due to the risk of latent TB infection reactivation. This bibliometric–systematic literature review synthesised evidence from 17 peer-reviewed studies (2020–2025) evaluating adalimumab administered with concurrent prophylactic antitubercular therapy. Thematic synthesis and bibliometric mapping using VOSviewer demonstrated that adalimumab achieved 60–85% clinical remission in moderate-to-severe CD and axial spondyloarthritis while enhancing mucosal healing. However, 1–3% of patients developed active TB despite appropriate screening and isoniazid prophylaxis, revealing false-negative diagnostics and partial chemoprophylaxis protection. These findings highlight the need for region-specific frameworks integrating …

Strategies Of Science Denial In Contemporary Politics, Yumi Li

Undergraduate Research and Engagement Symposium

My presentation applies the FLICC acronym to different sources of science denial during the COVID-19 pandemic and Trump's handling of it.

Honest Like A Bear Attack, Clare Magneson

Creative Nonfiction Magazine

No abstract provided.

Igg4-Related Disease Associated With Pearson Syndrome: A Case Of Rapid Decline, Kai-Jing Zhang, Xiao-Juan Lv, Qin-Qin Zhao, Wan-Wan Xu

Journal of Pediatric Infectious Diseases

We report a diagnostically challenging case of a 1-year-old female with refractory thrombocytopenia, sideroblastic anemia, pancreatitis and metabolic decompensation, ultimately attributed to coexisting IgG4-related disease (IgG4-RD) and Pearson syndrome (PS)—a previously undocumented association. Key findings of the case were 1. Treatment resistant thrombocytopenia despite IVIG, corticosteroids, and eltrombopag (transient response only). 2. Elevated IgG4 (840 μg/mL) and pancreatitis thought to be secondary to IgG4-RD. 3. Mitochondrial DNA deletion (m.10052_15604 del, 93.2% heteroplasmy) and ringed sideroblasts secondary to PS. 4. Fatal Metabolic Crisis with hyperlactatemia (peak 8.4 mmol/L) and cardiac failure, underscoring PS's rapid progression. This is the first reported association …

Il-36Γ And The Development And Validation Of An Early Prediction Model For Severe Mycoplasma Pneumoniae Pneumonia In Children, Xiaodong Tang, Ying Li, Pao Yu, Wenpeng Wang, Bi Zhou

Journal of Pediatric Infectious Diseases

Objective: This study aimed to retrospectively analyze clinical data from pediatric patients with Mycoplasma pneumoniae pneumonia (MPP), investigate the expression and clinical significance of serum IL-36γ, and to develop and validate an early identification model for severe MPP (SMPP). Methods: Clinical data were collected from 345 children diagnosed with MPP in our department between July 1, 2023, and December 31, 2024. Based on diagnostic criteria, enrolled patients were categorized into an SMPP group (n=145) and a non-severe MPP (NSMPP) group (n=200). Serum IL-36γ levels at admission were measured using ELISA. Independent risk factors for SMPP were identified via binary logistic …

Evaluation Of The Oral Mycobiota In Pediatric Patients With Newly Diagnosed Malignancy, Gülşah Ece Özmerdiven, Gonca Erköse Genç, Serap Karaman, İlvana Çaklovica Küçükkaya, Zeynep Karakaş, Deniz Tuğcu, Ayşe Özkan Karagenç, Hikmet Gülşah Tanyıldız, Ayşegül Ünüvar, Zayre Erturan

Journal of Pediatric Infectious Diseases

Objective: This study examines whether the oral mycobiome of pediatric patients with newly diagnosed hematologic or oncologic malignancies differs from that of healthy children before treatment begins. Methods: The study included 117 children under 18 years of age: 67 patients and 50 healthy controls. Oral swab/rinse samples were cultured on various agar media, and fungal species were identified using conventional methods, API ID 32C, and MALDI-TOF MS. Antifungal susceptibility testing of non-albicans Candida (NAC) isolates was performed using VITEK2. Results: Yeast growth was observed in 58.2% of patients and 68% of healthy children. Candida albicans was the most frequently isolated …

Characterisics Of Children Evaluated For Simultaneous Crimean-Congo Hemorrhagic Fever And Brucellosis In An Endemic Region, Kübra Fırtına Topcu, Ayşe Hümeyra Taşkın Kafa, Elif Ünver Korğalı Sivas Cumhuriyet University, Faculty Of Medicine, Department Of Pediatrics, Sivas, Türkiye

Journal of Pediatric Infectious Diseases

Objective: Crimean–Congo hemorrhagic fever (CCHF) and brucellosis are two zoonoses that co-circulate in overlapping endemic areas and share similar clinical features. They may occur concurrently in the same patient. Methods: We aimed to investigate the occurrence of concurrent CCHF and brucellosis in pediatric patients from our endemic region. Results: We reviewed 31 patients younger than 18 years who, between January 2018 and December 2024, underwent concurrent testing with CCHF PCR and the Brucella serum agglutination test (SAT), along with their presenting complaints. Rural residence was present in 45.2% of cases, and a history of tick bite prior to presentation in …

Expression Of Metrnl, Presepsin, And Bmp9 In Peripheral Blood Of Children With Sepsis And Their Roles In Diagnosis And Prognosis, Yang Liu, Cheng Wei

Journal of Pediatric Infectious Diseases

Objective: Meteorin-like protein (METRNL), soluble CD14 subtype (presepsin), and bone morphogenetic protein 9 (BMP9) show promising for sepsis diagnosis and prognosis assessment in children. Their diagnostic and prognostic utility is comprehensively assessed in this study. Methods: A total of 360 children, aged 3-14 years, with sepsis, infection, and healthy groups were retrospectively analyzed. Receiver Operating Characteristic curve evaluated the diagnostic performance of METRNL, presepsin, and BMP9 for sepsis. The 28-day prognostic information was collected for the sepsis group. Risk factors for poor prognosis in the sepsis group were analyzed using logistic regression. A nomogram prediction model for prognostic prediction in …

Bronchiectasis In Children, Murat Kuru, Tamer Altınok

Journal of Pediatric Infectious Diseases

Bronchiectasis, although less common in children than in adults, is an important long-standing respiratory disease marked by permanent enlargement of the bronchi and impaired airway function. The main symptom is a chronic wet cough. This condition presents a considerable health challenge in children, especially in developing countries where access to healthcare may be limited. Although cystic fibrosis (CF)-related bronchiectasis is relatively common, non-CF bronchiectasis, often triggered by post-infectious causes, predominates in pediatric populations. The diagnosis of bronchiectasis is confirmed by demonstrating a bronchoarterial ratio > 0.8 on high-resolution computed tomography. Medical treatment includes mucolytic agents, bronchodilators and antibiotics. Surgical resection of …

Contributing Reviewers In 2025, - -

Journal of Pediatric Infectious Diseases

No abstract provided.

Exploring Noise Induced Extreme Events In Neuronal Oscillators Networks And Machine Learning Forecasts, Hariharan S Mr

Theses and Dissertations

This doctoral dissertation comprehensively investigates the underexplored phenomenon of noise-induced extreme events (EE). The word “extreme” is accompanied by an occurring “event” when the deviation is extreme or higher than that of regular occurrences. These extreme occurrences are rare, abrupt, sudden, and irregular, often causing a profound impact on the system and its surroundings. Tsunami, earthquakes, solar flares, and tornadoes are such events that do not occur often but still significantly cause damage to mankind. This thesis particularly focuses on EE in neuronal systems where sudden synchronization can trigger seizures, tremors, and strokes which serve as classic examples of such …

Nurse-Led Transformation: Evaluating The Impact Of A Professional Development Intervention On Interprofessional Collaboration, Amanda Kay Garey

Creating Healthy Work Environments (CHWE)

Interprofessional collaboration (IPC) is critical in improving positive patient outcomes and achieving the quadruple aim of enhancing patient experience, improving population health, reducing costs, and improving the work-life balance of healthcare providers. Interprofessional collaboration (IPC) effectively enhances the patient experience and healthcare quality (McGuier et al., 2021). According to the Interprofessional Education Collaborative (IPEC), critical drivers for the ongoing growth of developing interprofessional collaborative practice include the need to empower the interprofessional (IPE) community with the best available evidence and research related to IPE and collaborative practice, conduct a continuous review of standard terms for competence, competency, and competency framework, …

Temperature And Sex Ratios At Birth, Jasmin Abdel Ghany, Joshua Wilde, Anna Dimitrova, Ridhi Kashyap, Raya Muttarak

Publications, Reports and Presentations

Human sex ratios at birth (SRBs) shape population composition and are closely linked to maternal health and gender discrimination. In the context of environmental change, SRBs may theoretically be skewed by physiological or behavioral responses to exposure to extreme heat. However, evidence for this is limited. In this study, we estimate the effect of prenatal exposure to temperature on birth sex by linking survey data on 5 million live births in 33 sub-Saharan African countries and India with high-resolution temperature data. To distinguish between spontaneous and induced abortions, we exploit sociodemographic differentials, exposure timing, and regional differences in son preference. …

Keeping Score, Renee Aukeman Prymus

Creative Nonfiction Magazine

No abstract provided.

The Disproportionate Impact Of Hiv On Young Women In Durban: Exploring Gendered Vulnerabilities And Socioeconomic Barriers, Adrian A. Nolasco

Capstone Collection

South Africa has a high rate of HIV, with young women in Durban especially affected due to social, economic, and cultural challenges. This study looks at the experiences of young women living with HIV and the views of healthcare professionals caring for them in KwaZulu-Natal. Using a qualitative, phenomenological approach, semi-structured interviews were conducted with five women and three medical professionals to explore how HIV affects their lives, the challenges they face, and how they cope.

The findings show that both structural and personal barriers make it hard for young women to stick to treatment. Long waits at clinics, limited …

A Qualitative Analysis Of Progress, Successes, And Challenges Among Indiana Recipients As Part Of A National Initiative To Reduce Covid-19–Related Health Disparities, Marla Winters, Lily Darbishire

Purdue Journal of Service-Learning and International Engagement

In light of the COVID-19 pandemic, the Centers for Disease Control and Prevention (CDC) provided funding to states as part of the CDC Disparities Grant initiative. The aim of the funding was to reduce chronic disease and COVID-19–related health disparities among vulnerable communities through four unique strategies. Funding was awarded to the Indiana Department of Health (IDOH) to begin an Indiana chapter of this initiative, called Indiana Healthy Opportunities for People Everywhere (I-HOPE). From 2021 to 2023, the IDOH provided I-HOPE funding to local communities (subgrantees) to support the design and implementation of programs to improve community health. For example, …

Changing Minds And Lives: A Substance Use Awareness Campaign, Alyssa Collins, Claire Wolfer-Jenkins, Rachel Isaac

Purdue Journal of Service-Learning and International Engagement

Introduction: In 2024, 48.4million Americans experienced a substance use disorder (SUD),with opioid use disorder representing a significant concern. In 2024, an estimated 8 million individuals misused opioids, contributing to 54,743 fatal overdoses. College students are particularly vulnerable, with 20% reporting illicit substance use within the past month, highlighting the urgent need for focused interventions in this population.

Project Overview: Boiler Substance Awareness Network (BSAN) is a campus initiative funded by the Lead Forward Fellowship grant. BSAN educates the Purdue community about SUD to reduce stigma and foster a recovery-friendly environment. The focus is on two objectives: preparing students to respond …

The Best Panaceas For Heartaches, Kristin Johnson

Creative Nonfiction Magazine

No abstract provided.

Tricks Of The Trade: How To Have Fun On The Job, Susan Bruns Rowe

Creative Nonfiction Magazine

No abstract provided.

Ethical Decision-Making And Modification Of Service Delivery: Social Workers In Connecticut During Covid, Marie Elana Hollingsworth

Walden Dissertations and Doctoral Studies

Social work professionals often experience demanding and intense situations while facing organizational restructuring during crisis situations. The purpose of this generic qualitative study was to explore the viewpoints of frontline social workers regarding their ethical decision-making processes in response to the mandatory modifications of the service delivery protocol during the COVID-19 pandemic. Enck’s biomedical and ethical decision-making framework grounded the study. Data were collected from semi-structured interviews with 10 frontline social workers in Connecticut who had been employed with a social service agency for at least 3 years, but no more than ten. Findings from coding and thematic analysis yielded …