Digital Commons Network^™

A Multisystem Presentation Of West Nile Neuroinvasive Disease: Lessons In Diagnostic Complexity, Carrine S. Kogulan, Philip Yusuf, Oluwafemi Ajibola

Student Publications

West Nile virus (WNV) is an uncommon but serious case of encephalitis and meningitis, often presenting with nonspecific symptoms that can mimic a wide range of infectious, metabolic, and endocrine disorders. We present the case of a 61-year-old male with multiple comorbidities who arrived with 5 days of fever, chills, profuse diarrhea, black stools, and worsening confusion. Initial evaluation in the emergency department revealed hyponatremia, transaminitis, and concern for tick-borne illness, prompting empiric doxycycline. However, the patient denied any tick bites. Given his known thyroid nodule and Burch-Wartofsky screening score of 70, he was empirically treated for thyroid storm despite …

Journal Ida 2021 100 1

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2019 98 4

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Unveiling The Night-Flowering Jasmine: A Comprehensive Review Of Nyctanthes Arbor-Tristis’ (Oleaceae) Phytochemistry, Ethnomedicine, And Therapeutic Potential, Subham Saha, Soumya Mitra, Tathagata Khanra, Saban Karmakar, Tamalica Hore, Subhash C. Mandal

International Journal of Traditional Knowledge

Nyctanthes arbor-tristis (NAT), typically known as Night-flowering Jasmine or Harsingar or Parijat, is one of the prominent medicinal plants indigenous to the Indian subcontinent. Its application dates back to ancient times, with substantial documentation in former religious texts. Native communities have traditionally used this for various human ailments and as an ornamental plant. Leaves, flowers, seeds and stems of this plant are rich in various primary and secondary metabolites, providing a wide range of pharmacological effects. The most abundantly found phytoconstituents belong to iridoid glycosides, such as arbortristosides. Comprehensive research has investigated its potential in anticancer, antiviral, and anti-inflammatory activities, …

The Underlying Connections Between Drug Abuse And Criminal Involvement, Jessica Sedor

Master of Arts in Human Services

In this composition, an analysis about the relationship between substance abuse and criminal engagement within specific types of crimes is explored. While examining this relationship, the importance of forensic rehabilitation within the criminal justice system is approached through advocacy of identifying risk factors and intergenerational patterns amongst the youth to reduce the abusive cycle of crime and addiction. This paper reflects the evident significance that it is imperative that human services professionals are aware of this relationship and how it can influence and impact one’s judgment, personality, decision making, and other criminogenic behaviors and attitudes. It is critical that the …

Adherence To Evidence-Based Practice In Childhood Immunization: A Mixed-Methods Study, Lydia Boampong Owusu

International Nursing Research Congress (INRC)

Immunization is one of the most effective public health measures for preventing infectious diseases in children (Baidya et al., 2024). Immunization safety and effectiveness depends on proper injection site management (Rishovd, 2014; World Health Organization, 2018). Globally, Evidence-Based Practices (EBP) are recommended to enhance immunization effectiveness and minimize unwanted side effects (Cataldi et al., 2020). However, there is a dearth of empirical evidence on healthcare provider adherence to EBP in injection site management which presents a significant knowledge gap, especially in developing countries. This study assessed the experience and understanding of healthcare providers' adherence to EBP in administering childhood vaccines …

Advancing Paternal Perinatal Mental Health: Integrating Qualitative Evidence, Theory, And Measurement Science, Rachael Elizabeth Schmitz

Nursing and Health Sciences

Aim: To advance understanding of paternal perinatal mental health through the integration of qualitative evidence, mid-range theory, and conceptual framework development.

Background: Existing scholarship largely emphasizes prevalence and symptom identification of paternal post partum depression, with limited integration of fathers lived experiences into theory development and assessment frameworks, and mental health nursing practice. Greater integration of qualitative evidence, theory, and measurement science may strengthen the recognition and assessment of paternal distress.

Methods & results: This integrative paper synthesizes findings from a phenomenological study of fathers with postpartum depression, the Reciprocal Adaptation in Postpartum Fathers mid-range nursing theory, and the P- …

Current And Emerging Plasmodium Falciparum Malaria Diagnostic Technologies: Performance, Feasibility, And Future Prospects, Vincent Obino Orucho

Polytechnic Journal

Introduction and Objectives: Malaria remains a life-threatening medical emergency, particularly in Plasmodium falciparum infections, with 282 million cases and approximately 610,000 deaths recorded globally in 2024. Accurate laboratory diagnosis is critical, yet conventional methods including microscopy and rapid diagnostic tests are constrained by operator dependency, low sensitivity, and emerging HRP2/HRP3 gene deletions. This scoping review maps current and emerging malaria diagnostic technologies, evaluates their performance, and identifies implementation challenges and knowledge gaps.

Methodology: Following the Arksey and O'Malley framework and PRISMA-ScR guidelines, PubMed, Scopus, and Web of Science were searched for publications from 2000 to 2026. Eligible studies involved human …

Staff Education To Improve Staff Knowledge Regarding Candida Auris, Nkechinyere Ejelonu

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice project was a staff education project regarding Candida auris, a multidrug-resistant fungus recognized by the Centers for Disease Control and Prevention (CDC) as an urgent global health threat due to its high mortality, environmental persistence, and resistance to common disinfectants. Staff play a crucial role in infection prevention; however, limited awareness and inconsistent knowledge of Candida auris contribute to potential transmission in skilled nursing home settings. The project question was as follows: Among staff members in a skilled nursing facility, does an evidence-based educational intervention improve knowledge of Candida auris infection prevention as compared pre- …

Mean Platelet Volume As A Marker Of Disease Severity In Hospitalized Children With Acute Bronchiolitis., Kedar Tilak, Trisha Sunderajan, Lewis Krata

Manuscripts, Articles, Book Chapters and Other Papers

Bronchiolitis is one of the most common lower respiratory tract infections affecting children less than two years of age and is a leading cause of hospitalization. Mean platelet volume (MPV), a readily available component of the complete blood count, has been investigated as an inflammatory biomarker in various conditions. Our present study evaluated the association between MPV values and the severity of acute bronchiolitis in hospitalized children.    Objective: The aim of this study was to determine the association between MPV, severity of respiratory distress, and need for oxygen support in hospitalized children under two years of age with acute bronchiolitis. …

Pacific Rxtracts - August 2026, Pacific Rxtracts

Pacific RxTracts

• Articles:
• FDA Approves First Oral Carbapenem Antibiotic for Complicated UTIs
• Bemotrizinol: First FDA-Approved Sunscreen Ingredient in 20 Years
• Effects of Mavacamten in Hypertrophic Cardiomyopathy
• Small Increase in Bleeding Risk With Immediate Intensive Statin Therapy and Dual Antiplatelet Therapy in Mild Ischemic Stroke
• Retatrutide for Type 2 Diabetes: The TRANSCEND-T2D-1 Phase 3 Trial
• Reimagining Insulin Therapy: Clinical Impact of CagriSema in REIMAGINE-3
• FDA Approval of Veligrotug-vvze Establishes a New IV Biologic Option for TED
• Novel Oral GLP-1 Receptor Agonist HRS-7535 Shows Promising Results in Type 2 Diabetes
• FDA Approves First Gene Therapy for Young Children with Sickle Cell Disease
• Pockets of …

The Effects Of Space On Pharmacology And Traditional Medicine: A Review Of Current Literature And Its Potential Impacts On Space Therapeutics, Pratyush Majumdar

Small Satellite Conference

Astronauts in space commonly take medicine for sleep disorders, muscle aches, and other miscellaneous conditions. These medications are taken under the assumption that they will work in space comparable to their effect on Earth, but mounting evidence is emerging to demonstrate that this is not the case. Using the principles of pharmacokinetics and pharmacodynamics, there are many physiological changes that alter how a drug is processed, changing their therapeutic effect. As mission times get longer, there is a heavier need to understand these changes and compensate for them in order to keep astronauts safe.

Compbio And Miras-A Multi-Omic Analysis Platform Built On A Memory-Based Intelligence Engine, Ruteja A Barve, Chad E Storer, Wayne D Hoxsie, Curtis Marcum, Joshua F Mcmichael, Jared M Lalmansingh, Brittany K Smith, Mark R Johnson, Daniel J Kuster, Richard D Head

2020-Current year OA Pubs

As molecular and cellular technologies have advanced, the need to analyze and interpret the resulting vast and multi-modal data into actionable intelligence has become a rate-limiting factor in scientific advancement. While traditional knowledgebase-pathway tools and LLM-based AI tools provide a degree of support in data interpretation, both exhibit known limitations. Presented here is the CompBio multi-omic analysis platform built upon Memory-based Intelligent Reasoning System (MIRaS), an associative reasoning engine grounded in episodic and semantic memory, capable of inferring biological relationships directly from stored knowledge rather than from model training. The MIRaS system is not dependent on human-curated pathway knowledgebases, provides …

Exploring Foundations Of Animal Host-Microbe Interactions In A Freshwater Sponge, Jacob S. Pawley

Electronic Theses and Dissertations

The most ancient eukaryotic immune defense mechanisms evolved in unicellular species. Multicellular eukaryotes, however, expanded these mechanisms to meet challenges unique to multicellular life, including barrier formation, long-distance cell signaling, and coordinated responses that eliminate microbial threats while minimizing damage to the host. As such, animal immune signaling pathways are exceptionally intricate and diverse. Though, most of what is understood about animal host–microbe interactions stems from a small handful of model systems. Here, I evaluate host–microbe interactions and innate immunity in sponges using the highly tractable freshwater sponge, Ephydatia muelleri. I report the discovery of an external host-derived matrix …

The Association Of Age, Race, And Gender And Novel Interventions In The Prevention Of Catheter-Associated Urinary Tract Infection, In Washington State, Lamin Darboe

Walden Dissertations and Doctoral Studies

Delayed removal of indwelling urinary catheters (IUCs) contributes to catheter-associated urinary tract infections, a leading healthcare-associated infection. A dot/smart-phrase communication tool, guided by the Health Belief Model construct of cues to action, to promote timely IUC removal interventions was evaluated in this quantitative, cross-sectional study. Secondary data from N = 372 adult patients with acute urinary retention in acute and critical care settings in Washington State were analyzed using SPSS Version 30. Binary logistic regression examined relationships among demographic variables, intervention-related factors (adherence within 48 hours, cosignature within 24 hours, and secure chat communication), and clinical outcomes (IUC removal and/or …

Identification And Characterization Of Novel Immune Modulating Genes In Parkinson's Disease, Kathleen Chaundy Paul Murphy

Dartmouth College Ph.D Dissertations

Parkinson’s disease (PD) is a progressive age-related neurodegenerative disorder characterized by both motor and non-motor symptoms. The poorly understood prodromal period, decades-long progression, and disease-phenotype heterogeneity continue to impede the development of preventive and curative therapies. A growing appreciation of immune system changes during the progression of PD suggests that evaluating peripheral immune cells may help identify signatures relevant to disease etiology. We aimed to expand our understanding of the peripheral immune compartment in PD via two lines of investigation: (1) by employing single-cell RNA sequencing to profile the transcriptomes of peripheral blood mononuclear cells (PBMCs) from a cohort of …

Countering Hpv Vaccine Misinformation On Social Media: Practical Strategies For Healthcare Providers, David Baldwin

Lynchburg Journal of Medical Science

Human papillomavirus (HPV) vaccination is a highly effective strategy for preventing cervical and other HPV-related cancers; however, vaccine hesitancy remains a significant barrier to optimal vaccination rates. Social media has become a major source of health information while simultaneously amplifying misinformation that influences parental attitudes toward HPV vaccination. This narrative literature review examined the relationship between social media misinformation and HPV vaccine hesitancy and identified evidence-based strategies healthcare providers can use to improve vaccine confidence.

A literature search of PubMed and Google Scholar identified 31 articles published between 2016 and 2025, of which 19 met inclusion criteria. The literature demonstrates …

Post-Pandemic Telebehavioral Health: Sustaining And Regulating Remote Mental Health Care As A Core Modality, Weiqiao Dong

Dartmouth College Master’s Theses

The United States continues to face a persistent mental health crisis after the COVID-19 pandemic, raising a policy question about the long-term role and regulation of telebehavioral health as a core modality of care. This thesis examines that question through a case study of New York State, an early center of the pandemic and a leader in telehealth policy reform.

Guided by the Health Policy Triangle framework, this thesis integrates longitudinal data from all 62 New York counties for 2010-2025 with a 2025 cross-sectional dataset covering 61 counties. Seventeen standardized indicators are organized into four dimensions: geographic, economic, demographic, and …

Clinical Practice Guideline For Sepsis In Skilled Nursing Facility, Chinyere Okoroh

Walden Dissertations and Doctoral Studies

Sepsis is a life-threatening condition that can rapidly lead to organ dysfunction, septic shock, and death if not recognized and treated early. Older adults in skilled nursing facilities (SNFs) are especially vulnerable because of age-related physiological changes, chronic conditions, weakened immunity, and increased exposure to infections. Consequently, sepsis remains a major cause of hospital readmissions, mortality, and healthcare utilization among SNF residents. The SNF serving as the site for this Doctor of Nursing Practice (DNP) project experienced increased hospital readmissions associated with recurrent sepsis, highlighting the need for a standardized, evidence-based approach to sepsis recognition and management. The practice-focused question …

Understanding Relapse And The Correlation With Group Counseling Accountability, Attendance, And Attitudes, Willie Sanders

Walden Dissertations and Doctoral Studies

Substance abuse continues to create significant personal, family, and legal challenges, yet limited research exists on mandated clients receiving counseling within rural municipal court systems. Studying factors associated with relapse allows counselors and counselor educators to develop interventions to prevent relapse and improve treatment outcomes. The purpose of this quantitative study was to investigate the relationship between group counseling attributes of attendance, accountability, attitudes and the level of relapse rates among rural municipal court clients in Columbus, Mississippi, as measured by the DEF, Subtle, Face Valid Alcohol, Face Valid Other Drugs, and the OAT Scales of the SASSI-4 Assessment. Theoretical …

Abnormal Presentation Of An Intra-Abdominal Desmoid Tumor In A Young, Healthy Male: A Case Report, Erica Kozorosky, Konstantina Kostara, Zohaa Ahmad, Benetta Miller, Zbigniew Moszczynski

Student Publications

Desmoid tumors are soft tissue proliferations with a tendency to invade surrounding tissues and, when occurring in the mesentery, can present with obstructive symptoms, pain, or organ damage. This report presents a case of a 33-year-old male with no medical history or contributory family history who developed systemic infectious symptoms related to cystic necrosis of a desmoid tumor. The cystic necrosis suggests that the tumor may have grown so rapidly that it outgrew its vascular supply before causing any symptoms, highlighting the diverse range of presentations and emphasizing individualized treatment plans.

Promoting Scientific Impact At The Nih, Fred D. Ledley M.D.

CISI Publication

We are honored to offer our comments on Promoting Scientific Impact at the NIH in response to NOT-OD-26-087: Request for Information on Measuring and Rewarding Scientific Impact.

These comments are informed by my professional experience as the founding director of the Center for Integration of Science and Industry at Bentley University, which has a mission to “advance the translation of scientific discoveries for public value by engaging science, business, and policy in transdisciplinary dialogue, scholarship, and education.” Our approach is to bring together the perspectives of natural science, business, analytics, economics, law, and policy to better understand, and advance, the …

Necropsy Findings Reveal Potential Threats To Native Florida Chelonian Species, Paige A. Spurlock

OneUSF Summer Undergraduate Research Symposium

Necropsies are vital for providing researchers with more information on the underlying conditions that cause disease and death in wildlife. A standard herpetological necropsy, like any necropsy, requires one to look objectively at each specimen, without preconceived expectations as to the cause, beginning with thorough internal and external examination of organs and tissues. This summer, I conducted 15 Chelonian (turtle and tortoise) necropsies. Species included gopher tortoise (n=11), and seral freshwater turtle species (n=4). Beyond gross examination, I collected cloacal/oral swabs, liver, lung, kidney, spleen, and brain for potential testing. Most were in good condition. We found a range of …

Fmea-Based Risk Assessment And Improvements For Vascular Access Education In Hemodialysis, Nai-Hua Hsiao

International Nursing Research Congress (INRC)

This study evaluates and improves the patient education and care process before and after arteriovenous fistula surgery in hemodialysis patients. Inadequate implementation of this process may lead to multiple clinical risks. Currently, Southern X Hospital lacks a standardized patient education protocol, resulting in duplicated, omitted, or inconsistent content. These deficiencies negatively affect patients' comprehension and adherence, potentially leading to resource waste and reduced dialysis quality. To address these issues, this study applies Failure Mode and Effects Analysis (FMEA) to systematically identify potential failure modes within the education and care continuum. The CRITIC (Criteria Importance Through Intercriteria Correlation) method is used …

Molecular Pathogenesis And Genomic Profiling Of Fusobacterium Nucleatum: A Review Of Virulence Determinants & Antimicrobial Resistance Mechanisms In Dental And Systemic Infections, Mawahb Hatem Mones, Thariat Abdualrahman Al-Joubori, Ibrahim Faisal Ibrahim

Muthanna Medical Journal

Fusobacterium nucleatum is one of the key bacteria in the oral microbiota, which plays a key role in the structural integrity of dental plaque, an anaerobic bacterium. Emerging clinical evidence has increasingly linked this opportunistic pathogen to severe systemic pathologies, notably colorectal cancer and adverse pregnancy outcomes. This review synthesizes current genomic and molecular insights to elucidate the complex mechanisms driving fusobacterial virulence and antimicrobial resistance (AMR). We critically discuss the roles of key adhesins, such as FadA and Fap2, in modulating host cell signaling and facilitating immune evasion. Furthermore, we determine the genomic architecture involved in the transfer …

Antifungal Activity Of Isolated Compounds From Centaurea Salicifolia Var. Salicifolia Against Candida Species, Including Multidrug-Resistant C. Auris, C. Inconspicua, And C. Dubliniensis, Seli̇n Tufan, Di̇lek Şatana, Nur Tan

Turkish Journal of Chemistry

Natural compounds obtained from plants have always held great potential for drug discovery and, as such, have drawn the attention of researchers as novel antifungal molecules that can be effective against fungal resistance. The antifungal activity of sesquiterpene lactones has been extensively investigated against various fungal strains, but there is limited data on their antifungal activity against Candida species. Sesquiterpene lactones are abundant in the Asteraceae family, and 90% of identified sesquiterpene lactones have been isolated from members of this family. Three extracts obtained from the aerial parts of Centaurea salicifolia var. salicifolia, which had not been investigated prior to …

Chitosan Microparticle-Based Antibacterial Nasal Barrier Formulation And In Vivo Evaluations, Güli̇z Ak, Ayça Erek, Tuğba Karakayali, Şadi̇ye Çeti̇n, Şenay Şanlier

Turkish Journal of Chemistry

Microorganisms remain a major cause of infectious diseases, emphasizing the need for alternative and complementary antimicrobial strategies. In this context, plant-derived materials have attracted increasing attention for their antimicrobial and protective properties. Chitosan, a biocompatible and cationic biopolymer, has emerged as an effective carrier system for encapsulating such plant-derived components. In this study, chitosan microparticles were prepared through ionic gelation followed by spray drying and loaded with thyme oil and olive leaf extract. The resulting microparticles exhibited an average size of approximately 1.8 μm and a total phenolic content of 23 mg GAE/g. These microparticles were incorporated into a glycerin–starch …

A Poly-L-Lysine-Functionalized Electrochemical Immunosensor Enables Highly Sensitive Detection Of Tumor Necrosis Factor Receptor-Associated Protein 1, Berfi̇n Vural, Mustafa Kemal Sezgi̇ntürk

Turkish Journal of Chemistry

Tumor necrosis factor receptor-associated protein 1 (TRAP-1), a member of the mitochondrial heat shock protein family (HSP90), is essential for protein homeostasis, stress response, and cell cycle. TRAP-1 not only optimizes cellular energy production but also prevents cell death, thereby supporting the survival and proliferation of tumor cells. In addition to cancer, TRAP-1 has been associated with Parkinson’s disease, certain autoimmune disorders, and abnormalities in the kidney and urinary tract. In this study, a unique and useful indium tin oxide-polyethylene terephthalate (ITO–PET)-based electrochemical biosensor is described for detecting the biomarker TRAP-1. The ITO–PET electrode, selected as the working electrode, is …

The Role Of Green Competence In Enhancing Green Performance Among Healthcare Workers In Indonesian Community Health Centers, Dewi Susanna, Tris Eryando, Dwi Agustina, Artha Prabawa, Rabiatul Adawiah, Lusianah Lusianah, Ratna Sari Dewi

Media Kesehatan Masyarakat Indonesia

Climate change poses increasing risks to population health and healthcare systems worldwide. Primary healthcare facilities, partic-ularly community health centers, play a critical role in climate change mitigation and adaptation through environmentally sustainable practices. This study aimed to assess the level of green competency of Puskesmas staff and analyze relationship in the green behavior. A cross-sectional study was conducted among 102 personnel at the Community Health Center in East Jakarta, Indonesia, using a total sampling approach. Green competence was measured across five dimensions (knowledge, skills, abilities, attitudes, awareness) involving a structured questionnaire. Data were analyzed using descriptively and inferentially using chi-square …

Sara Slattery V. Main Line Health Inc

2026 Decisions

USDC for the Eastern District of Pennsylvania