Digital Commons Network^™

Diverse Misfolding Mutant Digestive Enzymes Cause Chronic Pancreatitis Through Common Pathways, Steven J Wilhelm, Grace E Curry, Neel Matiwala, Jianguo Lin, Tran Quach, Mark E Lowe, Miklós Sahin-Tóth, Xunjun K Xiao

2020-Current year OA Pubs

BACKGROUND & AIMS: Increasing evidence suggests that protein misfolding and proteotoxicity is an important mechanism of chronic pancreatitis (CP) in patients with genetic variants. Two mouse models carrying misfolding digestive enzyme variants, CPA1 N256K and PNLIP T221M, recapitulate the human CP phenotype. We hypothesized that both models develop CP through similar disease mechanisms.

METHODS: We conducted a comprehensive analysis of mice aged 1 to 6 months using histology, immunohistochemistry, protein immunoblotting, quantitative polymerase chain reaction (qPCR), transmission electron microscopy (TEM), and RNA sequencing (RNA-seq) analysis to characterize pancreatic pathological changes.

RESULTS: Both homozygous models exhibited CP hallmarks, including progressive acinar …

A Deep Learning Model To Guide Personalized Mechanical Circulatory Support Use In Cardiogenic Shock Patients Undergoing Pci, Amit P Amin, Richard G Bach, Darren C Tsang, Weili S Zheng, Raed A Qarajeh, Emmanouil S Brilakis, Hemant Kulkarni

2020-Current year OA Pubs

BACKGROUND: Cardiogenic shock (CS) in patients undergoing percutaneous coronary intervention (PCI) involves rapidly changing clinical, hemodynamic, and metabolic factors that current models cannot effectively integrate.

OBJECTIVES: The purpose of this study was to develop and validate a deep learning (DL) model to guide personalized use of mechanical circulatory support (MCS) devices in CS patients undergoing PCI.

METHODS: The authors analyzed data from 1,408 CS patients treated with intra-aortic balloon pump (IABP) or microaxial flow-pump (mAFP) at multiple hospitals (2004-2019). Clinical, hemodynamic, and metabolic variables from admission to MCS placement were compiled into longitudinal vectors. Using Python 3.7 and TabNet in …

Oculomics And Ai: The Eye As A Biomarker For Health Span, Joy Le Yi Wong, Rajendra S Apte, Et Al.

2020-Current year OA Pubs

As the world's population ages, the focus of healthcare is shifting from extending life span to promoting health span. There is an unmet need to identify sensitive and reliable markers of health span through more cost-effective and non-invasive methods, to enable early and effective intervention on modifiable aging factors. The eye offers a unique window into systemic health, providing direct visualization of the body's vascular and neural health. This review presents an overview of how various ocular structures can serve as biomarkers of health span-drawing on insights from ocular imaging, metabolomics, and proteomics, with evidence from basic science, animal models, …

Airway Management In Emergency Department Thoracotomy: A Narrative Review, Aaron J Lacy, Adam Liebendorfer, Sarah M Guess, Rami S Al-Aref, Anthony P Kronfli, Rachel E Armstrong, Amelia W Maiga, Alexander Bracey, Ryan N Barnicle

2020-Current year OA Pubs

INTRODUCTION: Emergency department thoracotomy (EDT) is a high-risk, life-saving intervention for patients in traumatic cardiac arrest. A critical component of EDT is airway management, typically performed by emergency physicians, yet formal guidance regarding optimal strategies remains limited. Airway management in this setting is uniquely complex due to concurrent anatomic injury, physiologic instability, and the procedural demands of thoracotomy.

DISCUSSION: Endotracheal intubation (ETI) during EDT presents multiple challenges. Anatomic difficulties may arise from facial or cervical trauma, restricted positioning, and the presence of cervical collars. Cognitive load is heightened by the chaotic, multidisciplinary environment, requiring strategies such as pre-briefing, checklists, and …

Foot-Specific Exercise Intervention For Forefoot Deformity In Individuals With Type 2 Diabetes And Peripheral Neuropathy: A Randomized Controlled Clinical Trial With 3-Year Follow-Up, J A Zellers, K Steger-May, P K Commean, H-J Jeong, E M Bullard, M J Mueller, M K Hastings

2020-Current year OA Pubs

BACKGROUND: Diabetes with peripheral neuropathy can lead to metatarsophalangeal joint (MTPJ) deformity. The purpose of this study was to estimate the effect of a foot-specific intervention on MTPJ deformity. Secondary aims were determining MTPJ deformity progression over 3 years and predictors of MTPJ deformity progression.

METHODS: Sixty people with type 2 diabetes and peripheral neuropathy were recruited for this randomized controlled clinical trial. Participants were assessed at baseline, 6 months (post-intervention), 1.5 years, and 3 years. A 6-month, foot-specific intervention in the experimental group was compared to a shoulder intervention in the control group. The primary outcome was change in …

A Single-Cell Atlas Characterizes Dysregulation Of The Bone Marrow Immune Microenvironment Associated With Outcomes In Multiple Myeloma, William C Pilcher, Lijun Yao, Yizhe Song, Kazuhito Sato, Julia T Wang, Reyka G Jayasinghe, Jennifer A Foltz, Mark A Fiala, Chiang I-Ling, Julie Fortier, Michael Slade, Stephen T Oh, Michael P Rettig, John F Dipersio, Shaji Kumar, Ravi Vij, Li Ding, Et Al.

2020-Current year OA Pubs

Multiple myeloma (MM) remains incurable despite advances in treatment options. Although tumor subtypes and specific DNA abnormalities are linked to worse prognosis, the impact of immune dysfunction on disease emergence and/or treatment sensitivity remains unclear. We developed an Immune Atlas of MM by generating profiles of 1,397,272 single cells from the bone marrow (BM) of 337 newly diagnosed participants and characterized immune and hematopoietic cell populations. Cytogenetic risk-based analysis revealed heterogeneous associations with T cells of BM, with 17p13 deletion showing distinct enrichment of a type 1 interferon signature. The disease progression-based analysis revealed the presence of a proinflammatory immune …

A Catecholamine-Independent Pathway Controlling Adaptive Adipocyte Lipolysis, Xiao Zhang, Sreejith S Panicker, Jordan M Bollinger, Anurag Majumdar, Rami Kheireddine, Lila F Dabill, Clara Kim, Brian Kleiboeker, Fengrui Zhang, Kristann L Magee, Adam Kepecs, Gretchen A Meyer, Irfan J Lodhi, Erica L Scheller, Et Al.

2020-Current year OA Pubs

Several adipose depots, including constitutive bone marrow adipose tissue, resist conventional lipolytic cues. However, under starvation, wasting or cachexia, the body eventually catabolizes stable adipocytes through unknown mechanisms. Here we developed a mouse model of brain-evoked depletion of all fat, including stable constitutive bone marrow adipose tissue, independent of food intake, to study this phenomenon. Genetic, surgical and chemical approaches demonstrated that catabolism of stable adipocytes required adipose triglyceride lipase-dependent lipolysis but was independent of local nerves, the sympathetic nervous system and catecholamines. Instead, concurrent hypoglycaemia and hypoinsulinaemia activated a potent catabolic state by suppressing lipid storage and increasing catecholamine-independent …

Perceived Hiv Risk, Barriers, And Preferences For Hiv Testing In Structurally Vulnerable Communities In St. Louis: A Best-Worst Scaling Survey, Emmanuel K Tetteh, Noelle Le Tourneau, Gregory Gross, Mckenzie Swan, Tyrell Manning, Justin Cole, Katie Wolf, Lawrence Hudson-Lewis, Julia D López, Todd Combs, Virginia R Mckay

2020-Current year OA Pubs

BackgroundPersistent gaps in efforts to end the HIV epidemic in the United States highlight the need for community-specific, evidence-based HIV testing strategies. This study investigated barriers and preferences around HIV testing among underserved populations, including Black, queer, and young adults in the St. Louis, Missouri area.MethodsWe conducted a Best-Worst Scaling (BWS) survey with adults (16+ years) recruited at community events, collecting responses electronically and providing a $25 incentive. The survey assessed the relative importance of 13 potential barriers to HIV testing such as stigma, structural barriers, and perceived HIV risk, chosen based on literature review and community input. Mean preference …

Comparison Of Breast And Gastric Her2 Immunohistochemistry (Ihc) Scoring Criteria In The Assessment Of Endometrial Carcinoma, Rachel L Furuya, Whitney Grither, Matthew A Powell, Premal H Thaker, Et Al.

2020-Current year OA Pubs

BACKGROUND: Immunohistochemistry (IHC) testing is the primary method to determine HER2 status at many institutions, often with reflex to in situ hybridization (ISH). DNA- and RNA- based platforms are emerging for HER-2 assessment. While approved IHC algorithms exist for HER2 scoring in breast and gastric carcinomas, neither has been validated in endometrial cancer. This study seeks to compare them and evaluate patterns of DNA and RNA expression.

METHODS: 263 endometrioid endometrial adenocarcinoma (EEA), 275 serous endometrial carcinoma (SEC), and 214 uterine carcinosarcoma (UCS) specimens were randomly selected. Previously stained HER2 IHC slides underwent blinded review by two board-certified pathologists and …

Defining Radiological Healing In Perianal Fistulizing Crohn's Disease: A Topclass Global Expert Delphi Consensus, Easan Anand, Jalpa Devi, David H Ballard, Shivani Joshi, Phil Tozer, Ailsa Hart, Anna Antoniou, Parakkal Deepak, Jaap Stoker, Phillip Lung, Topclass Collaborative Authors

2020-Current year OA Pubs

BACKGROUND & AIMS: Perianal fistulising Crohn's disease (pfCD) affects one-fifth of patients with Crohn's disease (CD), significantly affecting their quality of life. Magnetic resonance imaging is the gold standard for evaluating fistula healing in pfCD, but variability in radiological definitions hampers meaningful clinical interpretation and consistent trial design. This study aimed to establish an international consensus on the definition of radiological healing in pfCD.

METHODS: The study was conducted in 2 phases. Phase 1 involved a systematic review to identify magnetic resonance imaging-based variables and indices used to define healing in pfCD, assessing methodological quality using the COnsensus-based Standards for …

Implementation Strategies For Evidence-Based Healthcare Interventions In Rural And Remote Settings: A Scoping Review, Anna Chapman, Cadeyrn J. Gaskin, Hannah Beks, Charlene Wright, Skye Marshall, Elizabeth A. Johnston, Rebecca J. Bergin, Sharina Riva, Fiona Crawford-Williams, Camille E. Short, Nicole Kiss, Sze Lin Yoong, Nicolas H. Hart, Anna Wong Shee, Helena Rodi, Hannah Jongebloed, Anna Ugalde

Research outputs 2022 to 2026

Globally, people living in rural and remote areas experience poorer healthcare access and outcomes than urban populations. Applying implementation strategies that support the translation of evidence-based healthcare interventions may help reduce these inequities; however, real-world implementation is complex, and it remains unclear how strategies are applied and tailored to rural and remote contexts. This scoping review synthesised evidence on implementation strategies for healthcare interventions in rural and remote settings of high-income countries. Five databases (Ovid MEDLINE, Embase, Cochrane CENTRAL, CINAHL, Web of Science) were searched for peer-reviewed studies published between 1/1/2000 and 25/10/2024. Extracted data were synthesised using a descriptive …

Managing Hybrid Workers And Teams In The Public Sector: From Management By Results To Purposeful Management, Judy Lundy, Uma Jogulu, Helen Taylor, Sue Williamson

Research outputs 2022 to 2026

Purpose – Hybrid working has become “business as usual” in Australian public service (APS) organisations, however, limited guidance exists for managers in this sector. This paper aims to identify the management capabilities currently being used and those required for effective management of public sector hybrid workers. Design/methodology/approach – The research is based on the APS as a case study. The research team collected data from 20 focus groups and interviews with 83 managers and supervisors in the APS to answer: What capabilities are public sector managers using to manage hybrid working teams? What additional capabilities are needed? Findings – Participants …

Metaverse And Artificial Intelligence As Web 4.0: The Next Generation Of The Internet, Anton Klarin, Elena Gorenskaia, Qijie Xiao, Pi-Shen Seet

Research outputs 2022 to 2026

This study utilizes systems thinking to explore and entwine an evolving metaverse scholarship to a relatively underexplored phenomenon of Web 4.0. We adopt a soft systems thinking framework to guide the interpretation of complex and evolving metaverse scholarship, using bibliometric mapping of 5587 publications sourced from Scopus. Using systems thinking, we synthesize these clusters into the following four thematic areas: (i) business and society implications, (ii) optimization, (iii) integration with other technologies and (iv) metaverse education. Drawing on the largest-to-date review of the metaverse as well as a systematic review of Web 4.0 literature, we propose a novel conceptualization of …

Nursing Leadership And Pandemic Preparedness Via Game-Based Learning Simulation: A Narrative Review (Registered Nurses And Undergraduate Nursing Students), Scott James Andrews, Olivia Gallagher, Alecka Miles, Carol Crevacore, Brennen Mills

Research outputs 2022 to 2026

Background: Early progression of newly registered nurses into leadership roles is commonplace in clinical settings. Nurses and student nurses can prepare for leadership by gaining exposure through simulation-based learning. A novel and expanding modality are game-based learning (GBL) simulation. Nurse leaders play a crucial role during pandemics, guiding their teams through crises and ensuring effective response strategies. Reviewing the literature to identify the content, structure, and effectiveness of current pandemic preparedness and GBL simulation in nursing education is necessary to identify lessons learnt during the COVID-19 pandemic response to guide workforce preparation for future surge planning. Aim: The aim of …

Single Joint Posterior Chain Isometric Testing Using Force Plates: A Systematic Review Of The Methodologies And Reliability Of Testing Methods, Jack T. Fahey, Christopher Bramah, Richie Barber, James Williams, John J. Mcmahon, Paul Comfort, Nicholas J. Ripley

Research outputs 2022 to 2026

The posterior chain muscles (i.e. hamstring and gluteal) play an important role in performance and injury prevention. Posterior chain muscle injuries lead to time lost from training, competition and increased reinjury risk. Force plates enable valid and reliable assessment, current methods assessing isometric posterior chain (IPC) force production using force plates have yet to be reviewed. This review was designed to systematically review methods of single joint IPC force plate testing; establish existing reliability; and summarise descriptive data. A literature search was conducted using the following search terms: ‘force plat*’ AND ‘isometric’ AND (‘hamstring*’ OR ‘knee flex*’ OR ‘posterior chain’ …

The Gut Microbiome Mediates The Association Between A Flavonoid-Rich Diet And Masld In A Population-Level Analysis, William Bell, Amy Jennings, Nicola P. Bondonno, Andre Franke, Corinna Bang, Marcus Both, Jan Kassubek, Hans Peter Müller, Jan Borggrefe, Wolfgang Lieb, Tilman Kühn, Aedín Cassidy

Research outputs 2022 to 2026

Purpose: A growing body of evidence suggests diets rich in flavonoids may protect against metabolic-dysfunction associated steatotic liver disease (MASLD) development and progression. As the gut microbiome is important in the biotransformation of flavonoids to their constituent bioactive metabolites, studies on the potential mediating role of the gut microbiome in the association between dietary flavonoid intakes and MASLD are warranted but lacking. Thus, this study aims to examine the associations between a diet rich in flavonoids and MASLD, and assess the potential mediating role of the gut microbiome. Methods: In a cross-sectional analysis (n = 531), using the FlavoDiet score …

The Perceptions And Applications Of Cluster Sets In Strength And Conditioning, Tsuyoshi Nagatani, Shayne Vial, Kristina L. Kendall, Paul Comfort, Jiahao Yang, G. Gregory Haff

Research outputs 2022 to 2026

It is well documented that cluster sets, a modified set structure with additional rest between individual repetitions or groups of repetitions, can be used to modulate exercise-induced fatigue during resistance training. While practical guidelines exist, it remains unclear to what extent strength and conditioning (S&C) professionals utilise this programming tactic. The aim of this study was to examine S&C professionals’ perceptions of cluster sets and their application in practice. A secondary aim was to assess the alignment between cluster set programming tactics used in the field and evidence-based recommendations from the scientific and coaching literature. Forty-six S&C professionals (age: 40.0 …

Alcohol Advertising At The Beach: Insights From Young People In Western Australia, Renee N. Carey, Gemma Crawford, Nicola D'Orazio, Gina S.A. Trapp, Lauren Nimmo, Tina Lam, Jonine Jancey, Justine E. Leavy

Research outputs 2022 to 2026

Background: Advertising and marketing by the alcohol industry serve to normalise alcohol use, with exposure to alcohol advertising linked to earlier and riskier drinking among young people. Advertising that portrays alcohol use in and around waterways is of particular concern, with one in five fatal drownings being associated with alcohol. Objective: This study aimed to explore the types of alcohol advertising that young people were exposed to, and to determine whether exposure to alcohol advertising was related to their alcohol use in aquatic environments. Methods: We surveyed 102 young people aged 18 to 25 years attending a free event at …

Antecedents Of Employee Service Innovation Behaviour Through The Resource-Based View, Ataul Karim Patwary, Md Sazzad Hossain, S. Mostafa Rasoolimanesh, T. Ramayah

Research outputs 2022 to 2026

This study applies the Resource-Based View (RBV) to explore how strategic, tactical, and internal green marketing orientations foster employee service innovation behaviour in the hospitality sector. It examines green trust and responsibility feelings as key internal resources and investigates their mediating roles. Using PLS-SEM analysis on 778 responses from Malaysian hotel employees, the findings indicate that internal green marketing orientation significantly enhances green trust and responsibility feelings, which, in turn, positively influence employee service innovation behaviour. By integrating psychological constructs into RBV, this research offers new insights into the role of green marketing in driving organizational sustainability. However, the study …

Addressing Professional Tensions Through Intellectual Candour And Stewardship, Thoughtful Dialoguing As A Duoethnographic Collaborative Exploration, Sarah Barradell, Narelle Lemon

Research outputs 2022 to 2026

Using duoethnography, we explore our experiences of physiotherapy practice and education and argue that the profession’s desire for credibility is at the expense of vulnerability, risk and intellectual candour–of imagining the profession and education of its graduates differently. We identified key themes around: alignment/misalignment, reflection/reflexivity and professional scope. This methodology models risk and questioning through the juxtaposition of different perspectives. Through our contrasting narratives, we remain open to new forms of learning, modelling what intellectual candour demands from us: facing the problems of the past so that we might learn from our history and change our future. This can be …

Association Of Sarcopenic Obesity With Dementia Risk In A Cohort Of Older Women, Zhongyang Guan, Blossom C.M. Stephan, Lorenzo M. Donini, Joshua R. Lewis, Carla M. Prado, Richard L. Prince, David Scott, Kun Zhu, Marc Sim, Mario Siervo

Research outputs 2022 to 2026

Background and aims: Longitudinal studies have explored the association between sarcopenic obesity (SO) and the risk of cognitive impairment, yet findings remain mixed. This study aimed to investigate the associations of SO with risk of incident dementia in older women, using two diagnostic models: the Sarcopenic Obesity Global Leadership Initiative (SOGLI) and the load-capacity model. Methods: We analysed data from 900 community-dwelling women (aged ≥70 years). SO was defined using two models: (1) the SOGLI criteria, based on low handgrip strength (HGS), low appendicular lean soft tissue to body weight (ALST/W) ratio, and high fat mass percentage (%FM); and (2) …

Can Dual-Task High-Velocity Exercise Training Improve Cognitive Function In Older Adults? Secondary Analysis Of An 18-Month Cluster Randomized Controlled Trial, Jamie L. Tait, Rachel L. Duckham, Timo Rantalainen, Catherine M. Milte, Luana C. Main, Caryl A. Nowson, Kerrie M. Sanders, Dennis R. Taaffe, Keith D. Hill, Gavin Abbott, Robin M. Daly

Research outputs 2022 to 2026

Background Identifying strategies to mitigate age-associated cognitive decline is crucial. High-velocity power training enhances physical function in older adults and cognitive training has mixed cognitive benefits, however the combined effects of these interventions remain uncertain. Objective This 18-month cluster randomized controlled trial investigated whether dual-task functional power training (DT-FPT) enhances cognition in older adults and assessed if responses differ by apolipoprotein-E and brain-derived neurotrophic factor (BDNF) polymorphisms. Subjects and Methods Twenty-two independent-living retirement communities (300 residents, ≥65y at increased falls risk) were randomized to 12-months of group-based DT-FPT (6-months supervised +6-months maintenance, 45–60 minutes, 2/week) performed simultaneously with cognitive and/or …

Check-In To Sustainability: A Comparative Study Of Green Human Resource Management Practices In Emerging And Established Hotels, Abdul Razak Suleman, Mehran Nejati, Janice Redmond, Azadeh Shafaei

Research outputs 2022 to 2026

Purpose – This study draws on the Natural Resource-Based View (NRBV) to investigate the drivers, implementation and challenges of Green Human Resource Management (Green HRM) practices in Ghana's star-rated hotels. It also examines how these initiatives contribute to achieving relevant Sustainable Development Goals (SDGs). Design/methodology/approach – A qualitative research approach was adopted, involving in-depth interviews with twelve managerial employees purposively sampled from both emerging (1–2 star) and established (3–5 star) hotels in Ghana. Data were thematically analysed to uncover key patterns. Findings – The findings reveal that Green HRM adoption across star-rated hotels in Ghana is driven by a mix …

Circulating Tumor Cells In Uveal Melanoma: Multi-Marker Detection And Association With Disease State, Daniel P. De Bruyn, Fabiana Lucia Bassil, Mike Wu, Aaron B. Beasley, Jolanda Vaarwater, Mai N. Van, Jaco Kraan, Robert M. Verdijk, Dion Paridaens, Caroline M. Van Rij, Nicole C. Naus, Annelies De Klein, Elin S. Gray, Erwin Brosens, Emine Kiliç

Research outputs 2022 to 2026

Purpose. Uveal melanoma (UM) is primarily treated with eye-sparing radiotherapy, leaving limited tumor tissue for molecular analysis. Circulating tumor cells (CTCs) may offer a minimally invasive alternative for genomic tumor profiling. This pilot study evaluated the feasibility of a multi-marker CTC capture approach in UM patients at diagnosis, during fractionated stereotactic radiotherapy (fSRT), and at metastatic progression. Methods. Patients with localized or metastatic UM were prospectively enrolled. Peripheral blood samples were collected at baseline, during fSRT, and on detection of metastases. CTCs were captured and enumerated using a multi-marker approach and fluorescence microscopy. Results. A total of 76 patients were …

Compassionate Communities, Māori Ageing And End-Of-Life: A Systematic Review, Melissa Carey, Kathleen Mason, Levi Fox, Tess Moeke-Maxwell, Merryn Gott

Research outputs 2022 to 2026

Background: Māori people in Aotearoa New Zealand and Australia experience significant healthcare inequity as they age and towards the end of their lives. Compassionate community approaches to ageing and end-of-life care are increasing in popularity throughout the world. However, this approach has arisen from Eurocentric knowledge systems and not from First Nations people and their communities. Objectives: This research aimed to gain insight into what the Compassionate Communities approach means for First Nations people and identify implications for Māori in Aotearoa New Zealand and Australia. A systematic literature review explored the intersection of Compassionate Communities and First Nations peoples’ perspectives …

Embodied Tales Of Older Women And Their Relationship With Movement And Their Younger, Present And Future Selves, Valeria Varea, Robyne Garrett, Alfonso García-Monge, Gustavo González-Calvo

Research outputs 2022 to 2026

Ageing has been often seen as negative in Western cultures. Older bodies are frequently associated with decline, loss, dependency, illness and increasing incompetence. Significantly, this ‘decline model’ of ageing tends to ignore the diverse lived experiences of older adults. This paper draws on the theoretical concepts of embodiment and affect to explore the embodied experiences of a group of 17 older women, focussing on their relationship with movement and with their younger, present and future selves. We used a narrative analysis approach and creative nonfiction to represent the data. The findings are presented in composite narratives in the form of …

Exploring The Mechanisms Of Tanshinone Iia In The Treatment Of Intracranial Aneurysm Based On Network Pharmacology And Machine Learning, Wanqi Wang, Lois Balmer, Shaotao Weng

Research outputs 2022 to 2026

Background Intracranial aneurysm (IA) is a cerebrovascular disease with high mortality and limited treatment options. Tanshinone IIA (Tan IIA), a bioactive compound from Salvia miltiorrhiza , has shown vascular protective effects, but its mechanism in the treatment of IA remains unclear. Methods The GSE75436 dataset was used to identify differentially expressed genes (DEGs). Weighted gene co-expression network analysis (WGCNA) was performed to identify disease-related modules. IA targets were obtained from GeneCards and the Comparative Toxicogenomics Database (CTD). Potential targets of Tan IIA were predicted using TCMSP, SwissTargetPrediction, and SymMap. KEGG enrichment analysis was conducted for DEGs, WGCNA modules, disease-related genes, …

Functional Data Analysis Of Vertical Barbell Acceleration During The Pull Of The Power Clean, Tsuyoshi Nagatani, Shayne Vial, Kristina L. Kendall, Paul Comfort, G. Gregory Haff

Research outputs 2022 to 2026

The purpose of this study was to examine the relationship between vertical barbell acceleration patterns and power clean performance. Thirty strength-power athletes performed a one repetition maximum (1RM) power clean test, recording vertical barbell acceleration data from their heaviest successful lifts. This data was then analysed using functional principal component (fPC) analysis methods. Three vertical barbell acceleration patterns were extracted, with each primarily reflecting variations in the magnitude of vertical barbell acceleration during the second pull (fPC1), the transition (fPC2), and the first pull (fPC3). Additionally, two fPCs were extracted from displacement fields, which explain timing variations in barbell acceleration …

Predictors Of Quality Of Family Planning Counselling In Ethiopia: Multilevel Analysis Of The Spa Survey 2021/22, Kalayu Brhane Mruts, Tesfay Brhane Gebremariam, Amanuel Tesfay Gebremedhin

Research outputs 2022 to 2026

Background: High-quality family planning (FP) counselling is essential for informed contraceptive choice, reducing discontinuation, and improving reproductive health. However, many women in sub-Saharan Africa continue to face barriers. This study examined client-, provider-, and facility-level determinants of FP counselling quality in Ethiopia using nationally representative, multi-source data. Methods: We analysed data from the 2021/22 Ethiopia Service Provision Assessment, including 2,224 women who received or were prescribed injectables, pills, or implants. Counselling quality was assessed using a 15-item checklist derived from direct observations and client exit interviews. Multilevel ordinal logistic regression was applied to identify predictors at the client-, provider-, and …

Prevalence Of Dementia In Selected Middle East And North Africa (Mena) Countries: A Systematic Review And Meta-Analysis, Mohsen Sedighi, Mohammad Hasan Shahabi, Alireza Amanollahi, Khurshid Alam, Soudabeh Shemehsavar, Zahra Shirzadi, Serena Sabatini, Ahmad R. Khatoonabadi, Matthew Prina, Akram A. Hosseini, Claire V. Burley, Jennifer Dunne, Simin Mahinrad, Iman Dajani, Ralph N. Martins, Blossom C.M. Stephan, Ali Chaari, Hamid R. Sohrabi

Research outputs 2022 to 2026

Data on dementia epidemiology in the Middle East and North Africa (MENA) region is limited. This systematic review and meta-analysis examined dementia prevalence across MENA. Databases were searched up to October 2024. Analyses were stratified by country and sex. Pooled prevalence was estimated using a random-effects model with a 95% confidence interval (CI). Fifty-two studies on the selected countries met inclusion criteria, covering 87,219 individuals with dementia from a total population of 1,045,908. The pooled prevalence was 12.16% (95% CI: 9.61–14.96) for the region and the Israel had the highest prevalence (17.00%), followed by Iran (13.20%), Turkey (11.40%), Saudi Arabia …