Digital Commons Network^™

Economic Instrumentality Report Of Work & Occc, Manuel A. Rivera, Stephen Pratt, Frank Badu-Baiden, Margaret Zorrilla

Hospitality+™ Center for Innovation and Training

This report presents a comprehensive overview of the workforce supporting the OCCC, based on a research partnership with the University of Central Florida’s Rosen College of Hospitality Management. The analysis integrates nine interconnected studies examining workforce characteristics, job satisfaction, quality of life, commitment, retention, financial sustainability, and perceptions of meaning in work. Findings are based on 299 valid responses, representing front-line, supervisory, and managerial employees across the Central Florida events and tourism ecosystem.

Development Of Dashboards And Procedures For Using Connected Vehicle Data To Prioritize Investments In Electric Vehicle Related Infrastructure, Jairaj C. Desai, Nathaniel J. Sturdevant, George Mccue, Darcy M. Bullock

JTRP Technical Reports

The National Electric Vehicle Infrastructure (NEVI) Formula Program and the Charging and Fueling Infrastructure Discretionary Grant Program together provide $7.5 billion to support states with building out a nationwide EV charging network. Indiana’s Charging the Crossroads program, funded through the NEVI program, plans to invest almost $100 million to build an EV charging network along Indiana interstates and highways. There is broad consensus among states, that these fast charging station investments should be based upon quantitative geospatial data with the objective of maximizing the impact of the NEVI program investments.

However, traditional methods for monitoring electric vehicle (EV) usage have …

The Business Case For Sustainable Road Infrastructure Development, David Holguin Mejia, Deepak Benny, Dong Yoon Song, Konstantina Gkritza, Kumares Sinha, Samuel Labi

JTRP Technical Reports

This study developed a business-case framework for embedding sustainability into the Indiana Department of Transportation’s (INDOT) practices. The study first identified the role of sustainability in road infrastructure development, and then discussed strategic plans, sustainability programs, and institutional challenges that shape how sustainability actions are conceived and executed. The study reviewed existing sustainability rating systems, established exposure metrics, and subsequently developed a business-case framework called the Road Infrastructure Sustainability Evaluation (RISE) to guide INDOT in embedding sustainability across the full infrastructure lifecycle, from planning through end-of-life. RISE follows a multicriteria analysis approach, incorporating indicator selection, criteria evaluation, weighting, normalization, and …

Utilizing Emergency Management Audio Messages For Traffic Incident Management Performance Measures, Christopher Gartner, Vihaan Vajpayee, Jairaj Desai, Darcy M. Bullock

JTRP Technical Reports

Timely and accurate information regarding roadway incidents is critical for Traffic Management Centers (TMCs) to maintain safety and mobility. While Intelligent Transportation Systems (ITS) cameras and crowdsourced data provide significant visibility, rural interstate corridors often suffer from coverage gaps, or "blind spots," where incidents go undetected until significant queuing occurs. Public safety radio communications serve as the primary coordination method for first responders, creating a "verbal infrastructure" that contains vital information regarding incident location and severity. This study evaluates the feasibility of using Automatic Speech Recognition (ASR) to bridge these gaps by monitoring and analyzing radio traffic. The project developed …

Simulating Current And Future Ev Growth Scenarios In Indiana, Omar Faruqe Hamim, Xiaowei Chen, Kenny Chandra Wijaya, Lavan Teja Burra, Zengxiang Lei, Rajat Verma, Konstantina (Nadia) Gkritza, Satish Ukkusuri

JTRP Technical Reports

As Indiana transitions toward electric mobility, data-driven planning is essential to guide electric vehicle (EV) charging infrastructure investment and deployment. This study evaluates the current and future performance of Indiana’s EV charging infrastructure using Multimodal Energy-Efficient Trip Simulation in Real Time (METS-R), a high-resolution simulation platform. Five EV adoption scenarios, ranging from pessimistic to optimistic, are modeled for the years 2024 through 2031, to assess spatial and temporal variations in public charging demand. Results reveal increasing public charging demand under high adoption scenarios, with significant disparities between urban and non-urban areas. Accessibility to public charging is found to be uneven …

Relentless: The Pressures Shortening Law School Deanships And What Must Change, Katie Kempner, Patricia E. Roberts

Faculty Articles

It is no small thing when a law school loses its dean. The departure triggers a national search, stalls institutional momentum, disrupts fundraising, and requires rebuilding years of relationships with faculty, alumni, and university leadership, all while the institution navigates one of the most turbulent periods in legal education's history. Approximately 25 percent of the nation's law schools transition to a new dean in any given year. That reality prompted this study.

This study combined a survey of 624 current and former law school deans, which yielded 256 responses and data on 294 deanships, with 70 qualitative interviews conducted between …

Aba Renewal Of Fentanyl Seeking Using A Drug-Prime And Peer Stimulus In Rats, Meagan Blanchard

University of Kentucky Master's Theses

People with opioid use disorder can experience craving and relapse to use when exposed to cues that were previously paired with the drug-taking environment. These cues can be both social and non-social in nature. This study aimed to explore the effect of a peer cue and a drug-prime cue, both together and separately. First, rats were trained to self-administer fentanyl in Context A (peer and drug present). Then, rats extinguished this behavior in Context B (no peer and no drug present) while self-administering saline instead of fentanyl. Lastly, rats underwent 4 different renewal test conditions (control, peer only, drug only, …

The Lived Experiences Of Counselors Working With Adults Suffering From Major Depression In Nursing Home Facilities. A Qualitative Phenomenological Study Grounded In A Wellness Perspective, Melissa Arguelles De Jesus

All Student Theses and Dissertations

There is new knowledge that major depression disorder (MDD), specifically, is one of the most encountered mental health diagnoses assigned among older adult residents who live in a nursing home (NH) setting (Matos Queiros et al., 2021). Antidepressants are known to be the main improvement factor and optimal management for treating depression; however, consideration for other treatment modalities continues to be explored (Voineskos et al., 2020). Wellness counseling, which is known to foster a person-centered approach, may help NH residents develop coping skills to enhance both overall welfare and everyday functioning across multiple domains. Residents can be empowered as decision …

Developing Consumer Consensus On Remote Assessment And Management Of Physical Function In Older Adults (Ramp): International Modified Delphi Process, Elsa Dent, Christopher Hurst, Jack Dalla Via, Jackson J. Fyfe, Paul Jansons, Eleanor J. Hayes, Gary Skinner, Marc Sim, Mylene Aubertin-Leheudre, Sabine Britting, Fanny Buckinx, Gavin Connolly, Lora Giangregorio, Jennifer R.A. Jones, Pauline Kelly, Robert Kob, Suzanne N. Morin, Girish Nandakumar, Lucas B.R. Orssatto, Maria Pearson, Daniel Pinto, Esmee M. Reijnierse, Catherine M. Said, Mohamed Salem, Vina P.S. Tan, Rosanna Tran

Research outputs 2022 to 2026

Background: Remote health care delivery, including the use of digital health interventions, is emerging as a tool for assessing and managing physical function, but its design and implementation often overlook the needs and preferences of older adult end users. Objective: The primary aim of this modified Delphi process was to develop consumer consensus on preferences for remote assessment and management of physical function in older adults. Methods: Research and consumer experts of the Remote Assessment and Management of Physical Function in Older Adults (RAMP) Working Group co-developed the Round 1 Delphi survey, which was advertised to consumers (adults aged ≥60 …

Precision Exercise For Breast Cancer-Related Outcomes: Towards Personalised Training Based On Tumour, Treatment And Patient Characteristics, Cristina Crespo-Garcia, Anita Borsati, Dennis R. Taaffe, Carolyn J. Peddle-Mcintyre, John P. Campbell, Alice Avancini, Emily Jeffery, Daniel A. Galvao, Robert U. Newton

Research outputs 2022 to 2026

Exercise is a promising strategy associated with improved cancer-related outcomes through multiple biological mechanisms. However, current exercise guidelines largely adopt a one-size-fits-all approach and overlook inter-individual variability in response. Given the heterogeneity of breast cancer, precision exercise prescriptions may better target biological pathways linked to therapeutic efficacy and long-term prognosis. Observational studies consistently show that higher physical activity levels are associated with improved survival outcomes, including reduced all-cause and breast cancer-specific mortality. In contrast, evidence from interventional trials remains limited and inconsistent, with effects on tumour response and survival largely derived from secondary or exploratory analyses. These discrepancies likely reflect …

Comparison Of Breast And Gastric Her2 Immunohistochemistry (Ihc) Scoring Criteria In The Assessment Of Endometrial Carcinoma, Rachel L Furuya, Whitney Grither, Matthew A Powell, Premal H Thaker, Et Al.

2020-Current year OA Pubs

BACKGROUND: Immunohistochemistry (IHC) testing is the primary method to determine HER2 status at many institutions, often with reflex to in situ hybridization (ISH). DNA- and RNA- based platforms are emerging for HER-2 assessment. While approved IHC algorithms exist for HER2 scoring in breast and gastric carcinomas, neither has been validated in endometrial cancer. This study seeks to compare them and evaluate patterns of DNA and RNA expression.

METHODS: 263 endometrioid endometrial adenocarcinoma (EEA), 275 serous endometrial carcinoma (SEC), and 214 uterine carcinosarcoma (UCS) specimens were randomly selected. Previously stained HER2 IHC slides underwent blinded review by two board-certified pathologists and …

Influence Of Obesity And Insulin Resistance With Hepatic Steatosis On The Human Plasma Lipidome, Max C Petersen, Gordon I Smith, Aaron M Armando, Xiong Su, Oswald Quehenberger, Edward A Dennis, Samuel Klein

2020-Current year OA Pubs

Insulin resistance accompanied by hepatic steatosis is a common complication of obesity. In an effort to identify plasma lipids that could be biomarkers or causes of insulin resistance with steatosis in people with obesity, we evaluated the plasma lipidome in three distinct groups separated by adiposity, hepatic steatosis, and insulin sensitivity, assessed by using the hyperinsulinemic-euglycemic clamp procedure: i) insulin-sensitive lean (ISL, n = 13); ii) insulin-sensitive obese (ISO, n = 14); and iii) insulin-resistant obese with hepatic steatosis (IROS, n = 13). We evaluated 759 complex lipid species in 16 subclasses (including phospholipids, glycerolipids, sphingolipids, acylcarnitines, and cholesteryl esters) …

Reclaiming The Self: A Visual Narrative Of A Process Of Individuation Through Artistic Practice, Stacie Becker

Graduate Studies Theses and Dissertations 2026

Reclaiming the Self: A Visual Narrative of a Process of Individuation Through Artistic Practice features a multidisciplinary practice that uses visual narrative, metaphor, and symbolism to reconcile the complex intersections of internal and external identity-shaping experiences, informed by lived experience as a woman. Working across painting, mixed media, printmaking, book arts, sculpture, and restorative medical tattooing, the artist dissects the tension between internal identity and external expectations, addressing themes of gender roles, relationships, trauma, and agency. Various artistic methods serve not only as a process but also as a parallel for reclaiming, healing, and restoring an authentic, unashamed sense of …

Carbaryl Exposure Alters Gut Microbiome Composition Without Affecting Morphometrics In Eastern Purple Martin (Progne Subis Subis) Nestlings, Stephanie A. Gaspar

Graduate Studies Theses and Dissertations 2026

Eastern purple martins (Progne subis subis) rely entirely on human-provided nesting structures throughout their breeding range in eastern North America. To control haematophagous mites that commonly infest these nests, many landlords apply the carbamate insecticide, carbaryl. Although effective at reducing ectoparasite populations, carbaryl exposure may have unintended effects on the gut microbiome, growth, and condition of developing birds. This study examined the effects of carbaryl exposure on gut microbial communities and morphometric condition in wild nestlings. Nests were experimentally treated with carbaryl, and nestling morphometrics and fecal microbiomes were compared between treated and untreated groups at 18 days …

Preadmission Screening And Resident Review (Pasrr): An Initiative To Reduce Inpatient Length Of Stay, Tatiana Jaggars Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Efficacy And Safety Of Epcoritamab In Relapsed Or Refractory Large B-Cell Lymphoma: 3-Year Update From The Epcore Nhl-1 Trial, Yasmin H. Karimi, Chan Y. Cheah, Michael Roost Clausen, David Cunningham, Umar Farooq, Tatyana Feldman, Herve Ghesquieres, Wojciech Jurczak, Kim M. Linton, Tycel Phillips, Julie M. Vose, Won Seog Kim, Pegah Jafarinasabian, Barbara D'Angelo Månsson, David Soong, Andrew J. Steele, Zhu Li, Christian W. Eskelund, Martin Hutchings, Catherine Thieblemont

Journal Articles: Oncology and Hematology

Epcoritamab, a CD3xCD20 bispecific antibody, resulted in deep, durable responses with a manageable safety profile in patients with relapsed/refractory large B-cell lymphoma (LBCL) in EPCORE^® NHL-1 (NCT03625037). We report results from a 3-year follow-up. Adults with relapsed/refractory LBCL received epcoritamab until progressive disease or unacceptable toxicity. The primary endpoint was overall response rate (ORR). Median age was 64.0 years, 39% of patients received prior CAR T-cell treatment, and 75% were refractory to ≥ 2 consecutive lines of treatment. As of May 3, 2024 (median follow-up 37.1 months [range, 0.3-45.5]), ORR was 59% and complete response (CR) rate …

Persistence Of Pet Scan Positivity After Chemoimmunotherapy For Dlbcl, James O. Armitage, Matthew A. Lunning, Julie M. Vose, Dan L. Longo

Journal Articles: Oncology and Hematology

Approximately 80% of patients with diffuse large B-cell lymphoma achieve a complete response after chemoimmunotherapy as defined by positron emission tomography (PET) scan. However, not all patients who fail to achieve a metabolic complete response are destined to relapse. In a number of these patients, the PET scan is falsely positive (ie, 20%-40% in several large series), particularly when the PET scan has a Deauville score of 4. Reflexively intervening with salvage systemic therapy or radiotherapy in these patients is potentially harmful. It seems that very sensitive measurements of circulating tumor DNA might be able to differentiate between patients who …

Lisocabtagene Maraleucel Combined With Ibrutinib In R/R Cll Or Sll: Primary Results From Transcend Cll 004, William G. Wierda, Kathleen A. Dorritie, Jordan Gauthier, Rajneesh Nath, Thomas J. Kipps, Peter A. Riedell, Herbert A. Eradat, Saad S. Kenderian, Mohamed A. Kharfan-Dabaja, Nirav N. Shah, Scott R. Solomon, Deborah M. Stephens, Daniel A. Ermann, Jon E. Arnason, Abhinav Deol, Tatyana A. Feldman, Charalambos Babis Andreadis, Monalisa Ghosh, Shuo Ma, Stephen J. Schuster, Usama Gergis, Julie M. Vose, Jacob D. Soumerai, Koen Van Besien, Sherilyn A. Tuazon, Serena K. Perna, San-San Ou, Revathi Ananthakrishnan, Neha Rane, Eniko Papp, Sahar Ansari, Ethan G. Thompson, Abood Okal, Leanne Peiser, Yizhe Chen, Sanhita Sengupta, Pradipta Ranjan Ray, Jixian Wang, Tanya Siddiqi

Journal Articles: Oncology and Hematology

Patients in the liso-cel plus ibrutinib cohort of the phase 1/2, open-label TRANSCEND CLL 004 study had relapsed/refractory chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) and received liso-cel (50×106 [dose level (DL)1] or 100×106 [DL2] chimeric antigen receptor-positive T cells) with concurrent ibrutinib from enrollment through 90 days after liso-cel infusion or longer per investigator discretion. Primary end point was complete response/remission (CR)/CR with incomplete marrow recovery (CRi) by investigator assessment. Among 56 patients who received ibrutinib plus liso-cel (DL1, n=5; DL2, n=51), median (range) age was 64.5 years (44‒77), 98% had high-risk cytogenetics, 55% had progression on Bruton tyrosine …

The Efficacy Of Cgrp Antagonists Versus Other Non-Migraine Specific Medications As Prophylactic Treatment For Episodic And Chronic Migraine, Lauryn C. Hutto

The PA Department Journal of Medical Science

Introduction: Migraines are a disabling neurological condition affecting 12-15% of the population. Migraines are characterized by a unilateral throbbing headache lasting between 4 and 72 hours, often accompanied by photophobia, phonophobia, nausea, or vomiting. Until the approval of the first CGRP antagonist, Erenumab, in May 2018, the prophylactic treatment for migraines relied on non-migraine-specific medications, such as antihypertensives and antiepileptics. Studies have been done to determine the efficacy and safety of the new medications, but few have directly compared them to older non-migraine-specific medications used for prevention. The purpose of this paper is to compare the efficacy of CGRP …

The Role Of Conjunctive Hyperbaric Oxygen Therapy In Decreasing Amputations In Those With Diabetic Foot Ulcers: A Clinical Review, Jazmyne D. Smith

The PA Department Journal of Medical Science

Diabetic Foot Ulcers (DFU) are a common complication of Diabetes Mellitus, which is the most common cause of amputations in the US. The purpose of this clinical review is to analyze the impact of Hyperbaric Oxygen Therapy on reducing amputations and improving healing rates in DFUs. PubMed was searched using the key terms “Diabetic Foot Ulcer,” “Amputation,” and “Hyperbaric Oxygen Therapy.” With the addition of filters, Mesh terms, and Boolean operations, 18 results were yielded. The inclusion and exclusion criteria narrowed the search to 6 articles, which were used for this review. The 6 articles included in this study were …

Pharmacologic Therapy Versus Catheter Ablation For Atrial Fibrillation, Jahkarius Hargrove

The PA Department Journal of Medical Science

Introduction- Atrial fibrillation is a common type of cardiac arrythmia that affects many people across the world. Patients with atrial fibrillation are at high risk for complications and poor outcomes. Stroke is the most prominent complication of atrial fibrillation if left untreated. The purpose of this clinical review is to analyze which modality is a better first line treatment, antiarrhythmic drug therapy or catheter ablation for long term management of this arrythmia.

Methods- Pubmed was searched with a specific search strategy using key terms “cardiac”, “Arrythmia”, “Antiarrhythmic agents”, “radiofrequency ablation”, and “surgical operation”. Operators and filters such as …

Comparing Autografts And Bioengineered Skin Equivalents In The Management Of Severe Burns, Madison Hill

The PA Department Journal of Medical Science

INTRODUCTION: Severe burns are associated with high morbidity, mortality, and treatment costs, often requiring surgical intervention to restore the skin barrier and prevent complications like infection and hypothermia. Autologous skin grafting is the current gold standard for burn wound closure but may not be feasible in cases of large TBSA injuries with limited donor sites. Bioengineered skin equivalents, including acellular dermal substitutes and cell-based therapies, offer potential benefits in wound healing and scar quality while reducing donor site morbidity. This review evaluates the effectiveness of autografts compared to bioengineered skin equivalents in severe burn management, with a focus on healing …

Extracorporeal Shockwave Therapy For Plantar Fasciitis Pain Reduction, Nathan J. Lopez

The PA Department Journal of Medical Science

Introduction: Plantar fasciitis (PF), aka plantar heel pain (PHP), is a degenerative and debilitating musculoskeletal condition that is prevalent across various populations. There is some debate concerning the hierarchy of second-line treatment options. The purpose of this article is to compare the efficacy, as it relates to pain reduction, of extracorporeal shockwave therapy (ESWT) and other invasive, non-surgical interventions (injections, dry needling, etc.).

Methods: PubMed was searched using a specific search strategy with key terms "extracorporeal shockwave therapy" and "plantar fasciitis". Operators and filters were then applied to narrow results to 4 relevant and quality articles for review. …

Prevention Of The Recurrence Of Skin Cancer With The Use Of Nicotinamide, Ryan A. Reibling

The PA Department Journal of Medical Science

Introduction: Skin cancer is the most common form of cancer worldwide, caused by the accumulation of UV ray exposure that people are exposed to daily. The treatment options for skin cancer are costly and inconvenient, with a high chance of recurrence in different sun-exposed areas. Nicotinamide, a form of vitamin B3, has shown promising outcomes in reducing the chance of recurrent in high-risk individuals. The purpose of this review is to examine recent literature on the effectiveness of nicotinamide supplementation in lowering the risk of skin cancer recurrence compared to individuals who do not take it.

Methods: A comprehensive PubMed …

Post-Surgical Prognostic Outlook Comparison Of Off-Pump Vs. On-Pump Cabg Procedures, Tanner A. Hendricks

The PA Department Journal of Medical Science

Introduction: Coronary artery disease in the United States had 680,981 deaths in 2023 alone with 400,000 CABG procedures being done. Coronary artery bypass grafting is a procedure in which coronary arteries occluded by fatty plaques are revascularized to restore blood flow to the myocardium. There are two effective options for this procedure, one being the on-pump approach, and the other being off-pump. Both methods carry risks, such as stoke and MI, as well as benefits, but the question of which carries the better outlook on mortality and complications is up for debate. The purpose of this paper is to study …

Safety And Efficacy Of Stroke Prevention With Warfarin Vs. Direct Oral Anticoagulants In Patients With Atrial Fibrillation: A Clinical Review, Kenneth L. Gentry

The PA Department Journal of Medical Science

Introduction: Atrial fibrillation is one of the most common cardiac arrhythmias in adults. This condition greatly increases a patient’s risk for ischemic stroke and is responsible for one-third ischemic strokes. Current international guidelines recommend the use of oral anticoagulants for stroke prevention in patients with atrial fibrillation. The purpose of this review is to analyze the current literature directly comparing the safety and efficacy of direct oral anticoagulants and warfarin at preventing stroke.

Methods: The PubMed database was searched for the following key terms: vitamin k antagonist, direct oral anticoagulants, stroke, and atrial fibrillation. Boolean operators and MeSH terms …

Efficacy Of Metformin Compared To Insulin In The Management Of Gestational Diabetes, Sarah Mchale

The PA Department Journal of Medical Science

Intro: Gestational diabetes (GDM) is a condition in which pregnant women are unable to use insulin effectively, leading to increased levels of glucose in the body. Although insulin has traditionally been a first-line pharmacologic treatment for GDM, metformin is increasingly being explored as an alternative. The purpose of this clinical review is to analyze whether metformin could be a safe and effective oral antihyperglycemic option compared to insulin in the treatment of GDM.

Methods: PubMed was searched with a specific search strategy using the key terms “insulin,” “metformin,” “gestational diabetes,” and “blood glucose.” Operator and filters narrowed results to 19 …

Efficacy Of Zuranolone Use For Postpartum Depression, Diana G. Welliver

The PA Department Journal of Medical Science

Introduction: Postpartum depression is a major form of depression that occurs anytime within the first year after a woman gives birth. It is characterized by low moods, increased feelings of sadness and anxiety, and a decreased interest in one’s baby. It is commonly treated with the use of selective serotonin reuptake inhibitors (SSRIs), which present with negative side effects and have a long duration of onset. The purpose of this study is to evaluate the efficacy of zuranolone, a fast-acting neuroactive steroid and GABA-A receptor modulator, on its ability to reduce symptoms of postpartum depression.

Methods: The PubMed database was …

Deep Brain Stimulation For The Management Of Non-Motor Symptoms Related To Parkinson’S Disease, Kyla A. Wallaszek

The PA Department Journal of Medical Science

Introduction: Deep brain stimulation (DBS) is a modern neurosurgical technique where electrodes are implanted in specific brain areas and deliver electrical impulses in order to help regulate abnormal brain activity. DBS is used for the management of several neurological conditions and was approved by the FDA for the treatment of Parkinson’s disease in 2003. The purpose of this review is to analyze the effectiveness of DBS for the management of the non-motor symptoms related to Parkinson's disease.

Methods: PubMed was searched using the key terms “Parkinson disease,” “deep brain stimulation,” “voice,” “sleep,” “mood,” “cognition,” and “dysphagia.” Operators and filters narrowed …

Labor Induction Versus Expectant Management In Postterm Pregnancy: A Clinical Review, Marisa Putrasahan

The PA Department Journal of Medical Science

Introduction: Postterm pregnancy is associated with increased morbidity and mortality of infant and mother. Current practice varies in the management of late- and postterm pregnancies, with much discussion surrounding the risks and benefits of the intervention options provided to pregnant patients. This study aims to review literature comparing the effectiveness of induction of labor (IOL) with elective management (EM) in reducing adverse perinatal and maternal outcomes for pregnant patients approaching postterm.

Methods: A literature search was performed on PubMed using key terms “late term pregnancy,” “induction of labor,” and “expectant management.” Operators and additional search filters narrowed results …