Digital Commons Network^™

Expression Pattern Of The Hifα-Family In Equine Chorioallantois During Pregnancy And Placental Pathology, Yatta Boakari, Hossam El-Sheikh Ali, Gustavo Henrique Doná Rodrigues Almeida, Kirsten E. Scoggin, Claudia Barbosa Fernandes, Sophia Panelli Marchio, Mats H. T. Troedsson, Ana Claudia Oliveira Carreira

Maxwell H. Gluck Equine Research Center Faculty Publications

Equine placental dysfunction impairs fetal growth and disrupts pregnancy outcomes. Despite many advances in diagnosis, the molecular pathophysiology of equine placentitis and premature placental separation remains poorly understood. However, the hypoxia-inducible factor (HIF-α) pathway is related to placental hypoxia, and its modulation in placental diseases has been shown in other species. Therefore, we hypothesized that in conditions marked by equine placental dysfunction, oxygen deprivation in the chorioallantois membrane triggers the activation of the HIF-α pathway, which is related to molecular alterations associated with placental insufficiency. Accordingly, we compared the expression of HIF1A, HIF2A, HIF3A, and HIF1AN genes in equine chorioallantois …

Senolytic-Resistant Senescent Cells Have A Distinct Sasp Profile And Functional Impact: The Path To Developing Senosensitizers, Utkarsh Tripathi, Masayoshi Suda, Vagisha Kulshreshtha, Bryan T Piatkowski, Allyson K Palmer, Nino Giorgadze, Christina Inman, Nathan Gasek, Ming Xu, Kurt O Johnson, Tamar Pirtskhalava, Selim Chaib, Larissa P G Langhi Prata, Yi Zhu, Renuka Kandhaya-Pillai, Stefan G Tullius, Saranya P Wyles, Rambabu Majji, Hari Krishna Yalamanchili, David B Allison, Tamar Tchkonia, James L Kirkland

Faculty, Staff and Students Publications

The senescent cell (SC) fate is linked to aging, multiple disorders and diseases, and physical dysfunction. Senolytics, agents that selectively eliminate 30%-70% of SCs, act by transiently disabling the senescent cell antiapoptotic pathways (SCAPs), which defend those SCs that are proapoptotic and pro-inflammatory from their own senescence-associated secretory phenotype (SASP). Consistent with this, a JAK/STAT inhibitor, Ruxolitinib, which attenuates the pro-inflammatory SASP of senescent human preadipocytes, caused them to become "senolytic-resistant". Administering senolytics to obese mice selectively decreased the abundance of the subset of SCs that is pro-inflammatory. In cell cultures, the 30%-70% of human senescent preadipocytes or human umbilical …

Consumer Responses To Ethical And Privacy Concerns In Ai Chatbots: Evidence From Offensive Language, Gender Bias, And Digital Privacy, Jikhan Jeong

Economics Faculty Research & Creative Works

Due to the rapid innovation of artificial intelligence (AI) and big data, AI chatbots have become increasingly influential computational social systems (CSS) in everyday life. However, the expansion of interactions between AI chatbots and consumers has raised significant ethical and privacy concerns. Using data from an online survey, this study empirically examines how consumer concerns about AI ethics and privacy influence their intention to use AI chatbots. These concerns are categorized into three types: 1) offensive language (generated by AI chatbots or users); 2) gender-biased language (from either source); and 3) digital privacy violations. The findings suggest that prior experience …

The Weight Of Stigma, Rebekah A. King, Michael S. Sinha

All Faculty Scholarship

Many health care providers, both implicitly and explicitly, perpetuate stigma in their treatment of patients classified as obese. While medical professionals understand that a one-size-fits-all approach to treatment is ineffective, patients classified as obese are frequently offered limited treatment options that fail to account for their unique needs. Access to a range of effective treatment options has historically been limited, but new GLP-1 receptor agonist medicines like Wegovy (semaglutide) and Zepbound (tirzepatide), have shown incredible promise in addressing the obesity crisis. Unfortunately, these transformative drugs are costly, in high demand, and not widely covered by insurance, rendering them inaccessible for …

The Asexual Assumption, Faith K. Whatley-Blaine, Michael S. Sinha

All Faculty Scholarship

Inclusion-focused dating shows such as ‘Love on the Spectrum’ feature individuals with developmental or neurological disabilities on a quest for love. Despite the focus on disability representation, these shows perpetuate stigma against the disabled community by fostering an infantilizing portrayal of individuals with disabilities. This portrayal undermines the premise of encouraging meaningful romantic relationships and reinforces the stigmatizing association of asexuality with disability. This framing aligns with the broader societal narrative that individuals with disabilities are incapable of or lack interest in participating in romantic relationships or physical intimacy.

The stigma that associates asexuality with disability extends beyond mere entertainment, …

Room To Breathe: The Surprising Capaciousness Of Osh Act Preemption, Michael C. Duff

All Faculty Scholarship

This essay is part of a Saint Louis University Law Journal seminar, conducted by the Wefel Center for Employment Law, titled "Shifting Workplace Law in an Era of Federal Vacuums: Business as Usual or Polycrisis?" The symposium presumed that the federal government would be scaling back workforce regulatory enforcement dramatically in the shadow of DOGE and several other developments. The essay focuses on OSHA and more narrowly questions the extent to which the OSH Act preempts state and local efforts to regulate workplace safety and health. The essay shows that unless OSHA promulgates a full-blown “standard” – a tedious form …

Risk And Resistance: How Feminists Transformed The Law And Science Of Aids By Aziza Ahmed, Kailey Tam

Osgoode Hall Law Journal

Book review of : Risk and Resistance: How Transformed the Law and Science of AIDS by Aziza Ahmed

The Burden And Genetic Diversity Of Mycobacterium Bovis Infection In Humans In The Middle East And North Africa: A Systematic Review And Meta-Analysis, Tsegaye Shamebo, Aboma Zewude, Temesgen Mohammed, Nabeeha Abdelgaleel Hassan, Robert Barigye, Markos Tibbo, Ali Artaman, Gobena Ameni

All Works

Zoonotic tuberculosis (zTB) includes human tuberculosis caused by animal-associated Mycobacterium species, Mycobacterium bovis (M. bovis) being the major cause of zTB. This systematic review and meta-analysis was conducted to estimate the pooled burden of human M. bovis infection and describe the genetic diversity of M. bovis isolated from humans in the Middle East and North Africa (MENA) region. A literature search was conducted in PubMed/MEDLINE, Scopus, Web of Science, Embase, and Google Scholar, followed by manual screening of additional references. The literature used for this paper were published between 2000 and 2025. A random-effects meta-analysis was used to estimate the …

An Exploratory One Health Investigation Of Mycobacterium Tuberculosis Complex At The Camel–Human Interface In Abu Dhabi Emirate, United Arab Emirates, Gobena Ameni, Aboma Zewude, Asha Antony, Tsegaye Shamebo, Temesgen Mohammed, Nabeeha Hassan Abdelgaleel, Mohamud Sheek-Hussein, Balázs Ádám, Robert Barigye, Markos Tibbo

All Works

This exploratory cross-sectional One Health study characterized LIODetect TB-ST antibody reactivity in dromedary camels and abattoir workers in Abu Dhabi Emirate and investigated tuberculosis-compatible lesions in slaughtered camels. Sera from 356 camels sampled from farms and livestock holdings (izbas), 393 camels presented for slaughter at Al Bawadi Abattoir, and 86 abattoir workers were screened with LIODetect TB-ST. All 25 LIODetect-reactive slaughtered camels underwent detailed postmortem examination; nonreactive slaughtered camels were not examined postmortem. Lesions identified in two reactive camels were evaluated by histopathology, Ziehl–Neelsen staining, and IS6110 polymerase chain reaction (PCR). LIODetect reactivity was detected in 33/356 field camels (9.3%, …

Disconsents, Daryl J. Levinson, David E. Pozen

Faculty Scholarship

Consent is an indispensable standard and organizing principle in any liberal legal order that prizes self-directed autonomy, self-identified preferences, and collective agreement. Yet consent’s capacity to advance those values has become increasingly uncertain in a society beset by power imbalances, information asymmetries, and multiple forms of polarization. In this Article, we document how the rise of neoliberalism has led to greater reliance on consent throughout U.S. law, while at the same time leading to greater doubts about its moral efficacy and empirical feasibility. Connecting and generalizing pathologies of consent-based regulation that have been identified within myriad domains, the Article identifies …

Why Constitutional Argument Matters, Philip C. Bobbitt

Faculty Scholarship

The program for this symposium promised that I would be discussing the “descriptive grammar of constitutional law.” To put my purpose less benignly, I should say that I mean to attack the practice of limiting what I will call “modal analysis” to its descriptive virtues. Part of that attack will be the claim that courts and their commentators should pay closer attention to the modal requirements of the fundamental forms of constitutional discourse, but not because straying from this is a kind of grammatical faux pas. After all, if the system I have urged for constitutional analysis — the system …

Table Of Contents

The Griot - Southern Conference on African American Studies, Inc.

No abstract provided.

Health And Transportation Equity Issues In Rural Areas Of The Texas Megaregion, Gwendolyn C. Goodwin

The Griot - Southern Conference on African American Studies, Inc.

This study examines health and transportation inequities affecting rural residents within the Texas Triangle megaregion, focusing on the US 290 West and I-10 East corridors. While urban residents benefit from proximate hospitals, public transit, and specialized care, rural communities face physician shortages, hospital closures, and long travel distances for essential services. Data from the American Community Survey and HRSA reveal disproportionate disability rates among seniors and people of color, particularly in counties such as Jefferson and Orange. Transportation costs further burden low-income households, with rural residents traveling longer daily distances and spending a greater share of income on vehicle ownership. …

Tax In The Echo Chamber, Kathleen Delaney Thomas

Faculty Publications

This Essay explores the concept of social media echo chambers in the context of tax law. Specifically, in addressing this Symposium’s topic of “AI in Tax Law,” the Essay argues that a significant and growing number of taxpayers encounter information about the tax system through their interaction with social media content that is selected by machine-learning algorithms. Tax information, commentary, and advice abound on social media, and nearly eighty percent of those considered Gen-Z or millennials seek out tax and financial advice on social media platforms. Policymakers who are interested in keeping the public informed about the tax system, thereby …

The Arbitrary Myth: Challenging Trademark Law's Elevation Of Arbitrary Marks, Dustin Marlan

Faculty Publications

Under its Abercrombie spectrum, trademark law grants “arbitrary” marks—like APPLE for computers or AMAZON for retail—its highest form of protection, treating them as equivalent to fanciful marks such as KODAK or EXXON. This Article challenges that foundational assumption. Unlike fanciful marks, which are invented and enjoy strong source-identifying capacity due to their novelty, arbitrary marks draw on existing language through catachresis: a rhetorical move that repurposes a common word in novel commercial context. In doing so, arbitrary marks generate layered metaphoric meanings that more closely resemble the associative leaps of suggestive marks, rather than the invented distinctiveness of fanciful ones. …

Cryptic Mechanisms Of Post-Fire Nitrogen Recovery In Northern Conifer Forests, Robert Edward Heumann

Graduate Student Theses, Dissertations, & Professional Papers

In recent decades, northern conifer forests have experienced larger, more frequent and more intense wildfires. Severe, stand-replacing wildfire substantially reduces forest nitrogen (N) stocks, a critical nutrient that often limits net primary productivity on land. Continued increases in wildfire activity may exacerbate forest N limitation in the future. Yet, while research shows N stocks in northern conifer forests recover following severe wildfire, the processes that contribute to rapid increases in N during post-fire regeneration are unclear. Atmospheric deposition of N and known sources of biological N fixation cannot explain the observed post-fire N accumulations. This paradox raises the question: How …

Effectiveness Of Behavioral Cough Suppression Therapy In A Closed Enrollment Group Telehealth Delivery Model And Comparison To A Rolling Enrollment, Kinsey Louise Roberts

Graduate Student Theses, Dissertations, & Professional Papers

Background:

Refractory chronic cough (RCC) is a subtype of chronic cough (CC) that persists

despite guideline-based treatment and can negatively affect quality of life. Behavioral cough

suppression therapy (BCST), typically delivered by speech-language pathologists (SLPs), is an

effective treatment for RCC. However, access to BCST remains limited due to geographic

barriers and a shortage of trained providers. Group-based telehealth may help expand access to

treatment. This study evaluated the effectiveness of BCST delivered via telehealth using

a closed enrollment group model and compared outcomes to a rolling enrollment group model.

Methods:

In this prospective sequential cohort study 32 participants attended …

Beyond Words: The Horse-Human Encounter In Equine-Assisted Psychotherapy For Residential Substance Use Treatment, Leah Finch Lungren

Graduate Student Theses, Dissertations, & Professional Papers

Equine-assisted psychotherapy (EAP) has emerged as a promising experiential therapeutic intervention, yet the lived experience of adults participating in EAP within residential substance use disorder (SUD) treatment settings remains underexplored. This hermeneutic phenomenological study examined the lived experience of 12 adults who participated in EAP groups during residential SUD treatment across three treatment facilities in the United States. The primary research question was: What is the lived experience of participating in EAP for adults in residential SUD treatment? Data was collected through semi-structured interviews and analyzed through iterative hermeneutic interpretation guided by van Manen’s (1990) existential framework.

Six themes emerged …

Initial Qualitative Inquiry Into Social Proverb Use And Acceptability, Emma K. Hinds

Graduate Student Theses, Dissertations, & Professional Papers

Currently,  1 in 36 individuals are diagnosed with autism spectrum disorder (ASD), which is characterized by social communication differences and restricted and/or repetitive behaviors. Many children with ASD also present with sensory, behavioral, and emotional differences, underscoring the need for specialized, evidence-based interventions. Social proverb is a novel intervention approach developed by Dr. Schoffer Closson that provides in-the-moment guidance by explicitly stating expected social behaviors and the rationale behind them (e.g., “We cover our coughs, so we don’t spread germs”). To date, no research has examined the use of social proverbs as an intervention strategy. The purpose of this qualitative …

Instructor Created Video: Differences In Perception Of Administrative Support In Respiratory Care, Brian Daniel Cayko

Graduate Student Theses, Dissertations, & Professional Papers

Background: The recent proliferation of online education has highlighted the need to reduce transactional distance and increase the community of inquiry presence between the instructor and students and between students. This quantitative non-experimental study examined the differences in perception of administrative support for instructor-created video (ICV) between faculty and administrators within Commission on Accreditation of Respiratory Care (CoARC) higher education programs of Respiratory Care. Methodology: The Difference in Perception of Administrative Support (DPAS) survey was utilized to collect data from 93 valid participants through a snowball sampling method. Analysis was performed using an independent samples t test and Cohen's d …

From Environment To Population Dynamics: Integrating Physiology, Morphology, And Demography In A Montane Migratory Bird, Beverly Sunshine Domschot

Graduate Student Theses, Dissertations, & Professional Papers

Environmental variation shapes population dynamics by influencing how individuals acquire and allocate resources. However, the pathways linking environmental conditions to population-level outcomes remain difficult to resolve because they operate across multiple levels of biological organization. Traits such as physiology and morphology mediate these relationships by shaping how individuals respond to challenges and convert resources into survival and reproduction. Physiological traits can change rapidly in response to short-term conditions, whereas morphological traits reflect longer-term processes related to performance and energy balance. Despite their complementary roles, these traits are typically studied in isolation, limiting our ability to understand how environmental conditions propagate …

An Exploratory Analysis Of The Role Of Sex In Load Carriage, Rachel E. Perez, Dustin R. Slivka, Brent C. Ruby

Graduate Student Theses, Dissertations, & Professional Papers

Axially loaded weight may impose a metabolic demand equivalent to that of fat mass (FM) during load carriage. Males (M) typically have a lower body fat percentage than females (F), resulting in metabolic demand differences during load carriage that may be mitigated by accounting for FM in pack loads. PURPOSE: To determine whether normalizing pack load to FM equalizes metabolic cost across sexes during load carriage. METHODS: Twenty-eight participants (14M, 23 ± 5 y, 1.81 ± 0.07 m, 78.7 ± 10.0 kg, 12.7 ± 5.4% body fat, VO₂peak 4.18 ± 0.54 L·min^-1; 14F, 22 ± 4 …

Superintendent Accountability In High Achieving School Districts: A Qualitative Multiple Case Study In The State Of Washington, Kristin Lind Jacobs

Graduate Student Theses, Dissertations, & Professional Papers

The primary goal of a school district is to promote and support student academic achievement. Superintendents of public school districts across the United States should therefore be held accountable for student performance within their districts. Establishing a successful public school district requires interconnected relationships among the superintendent, the school board, accountability structures, and evaluation processes.

The purpose of this qualitative multiple case study was to understand how superintendent accountability, in regard to student achievement, was conducted and accomplished by school boards who believe they hold the superintendent accountable for student learning. This study focused on school boards governing high-achieving school …

Adults With Dyslexia: Experiences Accessing And Using Reading Strategies And Assistive Technology, Brenda Rosalie King

Graduate Student Theses, Dissertations, & Professional Papers

Dyslexia is a specific learning disorder of neurobiological origin characterized by persistent difficulties with accurate and/or fluent reading, word recognition, spelling, and decoding. Although dyslexia is widely recognized as a lifelong learning difference, the majority of research has historically focused on children and adolescents, with less attention given to adult experiences. The purpose of this study was to explore how adults with dyslexia access and use reading strategies and assistive technologies to support reading comprehension and independence across contexts. The study also examined barriers and supports influencing access to these tools, as well as the emotional experiences associated with their …

Pestilent Air, Contagious Evil: Infectious Disease In Early Modern Poland, Danielle Marie Airola

Graduate Student Theses, Dissertations, & Professional Papers

The individuals buried in the cemetery of Czysty Square and the population of the vanished village of Gać lived and died during the early modern period in what is now modern-day Poland. Epidemics broke out repeatedly during this time, and the skeletal remains of several individuals buried in Czysty Square’s cemetery display pathological changes suggestive of infectious disease. These non-specific morphological changes created a need for DNA testing to search for pathogens associated with these lesions. In contrast, Gać’s population declined over time until the village’s abandonment. This has led to a hypothesis of an epidemic having contributed to the …

Expectations In The Preservation Of Dna And Bacterial Organisms In Differential Montana Burials, Kaylee M. Hinds

Graduate Student Theses, Dissertations, & Professional Papers

This study investigates patterns of decomposition and biomolecular preservation in domestic pig (Sus scrofa domesticus) proxies under varying burial conditions in a cold, seasonal climate. Conducted at the Lubrecht Experimental Forest in western Montana, the project aims to evaluate DNA degradation, microbial activity, and environmental influences across shallow, deep, surface, and secondary burial contexts. Three pigs were placed in distinct burial treatments (surface exposure, partial burial, and full burial), with a fourth site later added following bear disturbance and carcass relocation. Environmental monitoring included temperature, and soil sampling before and throughout the decomposition process. Systematic sampling of bone, soft tissue, …

Advancing Understanding Of Lived Experience Of Unhoused People To Reduce Social Stigma And Promote Community Health: A Theoretically-Guided Photovoice Study, B-Rad Stephen Applegate

Graduate Student Theses, Dissertations, & Professional Papers

Homelessness is a persistent public health challenge shaped by structural inequities, stigma, and exclusion from social and health systems. Community-Based Participatory Research (CBPR) has increasingly been used to center the knowledge of people who are unhoused, yet limited attention has been given to the theoretical frameworks guiding this work across disciplines. The purpose of this dissertation was to examine theories and methods used in CBPR with unhoused populations and to explore the extension of Margaret Newman’s Theory of Health as Expanding Consciousness from a nursing-focused theory to a public health framework for understanding lived experience.

Using a scoping review methodology …

Ghostly Grieving In Theatre’S Now Also The Dramaturgy Of Perception And The Body In Contemporary American Ghost Plays, Jacob Mann Christiansen

Graduate Student Theses, Dissertations, & Professional Papers

“Ghostly Grieving in Theatre’s Now Also” explores how contemporary American plays and playwrights stage the dead as a way of understanding theatre’s unique language for dealing with the shared, complex human experience of grief. Focusing on theatrical ghosts and other “impossible” presences, I articulate how these figures function as dramaturgical devices. I also argue that theatre’s ghosts “set the stage” (as it were) for communicable meaning-making by inviting audiences into the tasks of creation and mourning.

My work draws on performance theory (especially phenomenological accounts of theatrical storytelling), on dramaturgical analysis, and on grief studies. In this dissertation project, I …

Lake As Body: Ecofeminism And Animacy At The Great Salt Lake, Shae Barber

Graduate Student Theses, Dissertations, & Professional Papers

Water shapes cultural, social, and ecological systems. Yet, dominant economic, political, and academic frameworks often treat water as a backdrop or passive resource, ignoring it as an active participant in meaning-making and relationship-building. Viewing water as “nonliving” obscures how it participates in and co-creates relationships, limiting understanding about impacts of and responses to climate change and environmental degradation.

This thesis takes a mixed-methods and participatory approach including semi-structured interview, photovoice, and participatory mapping to examine relational practices between environmental advocates and the Great Salt Lake, a desiccating saline lake in Utah, U.S. As the lake continues to decline, dominant Western …

From Mandate To Implementation: A Qualitative Content Analysis Of Early Childhood Coursework In Educational Leadership Preparation Programs, Anna Louise Puryear

Graduate Student Theses, Dissertations, & Professional Papers

Research on principal leadership in the P-3 continuum is limited, even though leadership is second only to teaching in its impact on student outcomes. Most leadership preparation programs emphasize K–12 content, with little focus on early childhood education. Illinois is the only state to codify legislation requiring early childhood content in educational leadership programs, offering a unique case to examine how such mandates are implemented. This study employed qualitative content analysis to investigate how institutions of higher education represent mandated early childhood content in graduate-level coursework. Data sources included program-level documents from 22 Illinois leadership preparation programs and course-level materials …