Digital Commons Network^™

Analysis Of Alternative Oxidase In Non-Angiosperm Plants, Anissa M. Francis

Theses and Dissertations (Comprehensive)

Alternative oxidase (AOX) is a mitochondrial terminal oxidase that provides an alternative pathway for electron transport, allowing plants to maintain respiratory flexibility under environmental stress conditions. While AOX has been extensively studied in angiosperms (flowering plants), little is known about its distribution and conservation in non-angiosperms. Based on gaps identified in the literature, this thesis investigated the distribution of AOX across non-angiosperm plant lineages. Although AOX is present in many green algae and is therefore considered to be an ancient protein that originated before the existence of non-angiosperm plants, it remains unclear whether the protein is uniformly distributed across these …

Supporting Latine Older Adults’ Nutrition And Physical Health Goals In Counseling, Zachary P. Mcniece, Jacqueline J. Bergman

Faculty Research, Scholarly, and Creative Activity

Latine older adults face disproportionate risk of chronic nutrition-related conditions and food insecurity, which can exacerbate or contribute to the development of mental health-related concerns. Cultural stigma toward mental illness can result in Latine clients, especially older adults, somatizing symptoms and focusing on physical health goals in counseling. Despite these intersecting needs, counselors often overlook clients’ physical health goals due to limited training and the assumption that medical providers alone should address them. This article advocates integrating basic, culturally responsive nutrition information into counseling practice to support client well-being while staying within the scope of practice. We offer practical recommendations …

The Christ Of The Asbury Road, E. Stanley Jones

The Asbury Journal

This is an unpublished sermon, given by E. Stanley Jones on May 8, 1942, at 11:00 am at a special assembly at Asbury College. The day was named E. Stanley Jones day by the administration, and the 1942 yearbook was dedicated to Dr. Jones, who was also a member of the Board of Trustees. Jones had been asked to adapt the idea of his most well-known book, The Christ of the Indian Road, to his experience and knowledge of Asbury in Wilmore, Kentucky. He provided several interesting points to help ground Asbury’s theological position of holiness and build on that …

A Tribal Hermeneutical Reading Of The Creation Narrative In Genesis 1:26-28, Enolyne Lyngdoh

The Asbury Journal

No abstract provided.

Influence Of Culture On The Practice Of Christianity Among Yoruba In Nigeria And Its Implications For Christian Missions, Olayinka John Akinola

The Asbury Journal

This study investigates the profound influence of Yoruba culture on the practice of Christianity among the Yoruba people in Nigeria. The Yoruba people group is in the western part of Africa with a larger percentage found in Nigeria. The Yoruba people of Nigeria have a rich cultural heritage that significantly influences the practice of Christianity among them. By employing a qualitative research approach, using descriptive research method, this study delves into the intricate relationships between Yoruba cultural values, beliefs, and practices and Christian teachings and practices.

The findings of this study reveal that Yoruba culture has significantly shaped the practice …

From The Editor, Robert Danielson Ph.D.

The Asbury Journal

No abstract provided.

The Role Of Christian Hospitality In Mission To The Diaspora Community, Angela Kalim

The Asbury Journal

Immigration enriches a country’s cultural landscape but also brings change to existing norms. Some people see immigration as a threat, but many missiologists see it as an opportunity from God for God’s church to engage the nations. In this paper, I will explore the role of Christian hospitality in mission to the diaspora community. I will first explore what Christian hospitality is, and how it is different from conventional hospitality by looking at how Christian hospitality was practiced in the Bible as well as in Christian tradition, specifically in the Benedictine community. Second, I will discuss the role of Christian …

The Life And Ministry Of Dr. Kate C. Woodhull, Elaine B. Peters

The Asbury Journal

This paper examines the life and ministry of Dr. Kate C. Woodhull, the first female physician sent to China by the Woman’s Board of Missions, as a case study in women’s medical missions in late Qing China. Drawing on archival and published sources, it traces Woodhull’s medical training, her twenty-eight years of service in Fuzhou, and the integration of healthcare, education, and evangelism in her work. The study highlights both the cultural assumptions shaping her missionary outlook and her sustained advocacy for Chinese women, whom she trained as medical and Christian workers, leaving an institutional and social impact.

Why The New York Conference Was “An (Ineffective) Auxiliary Of The Colonization Society In Everything But Name”: Rejection, Apathy, (Lack Of) Funding, And (Its Own) Abolitionists, Philip Hardt

The Asbury Journal

Several years after the founding of the American Colonization Society (hereafter, ACS) in 1816, Methodist clergy and laymen in the New York Conference and especially in New York City began to support its twin goals of evangelization and emigration of free blacks to Africa. Of course, they did not expect the entire black population to emigrate. Instead, they (mistakenly, for the most part) thought many free blacks would prefer to leave the racism of America and start a new life in Africa. Their efforts, however, met with little success because of nearly unanimous black opposition, general white apathy, chronic financial …

For All The Saints: Sanctification, Autism, And A Rethinking Of Sainthood, Dean G. Blevins

The Asbury Journal

This article explores the intersection of sanctification, worship, and autism within Wesleyan traditions, arguing that autistic persons embody a truer vision of sainthood by challenging the “cult of normalcy” that often governs congregational life. Drawing on historical perspectives of sainthood, theological anthropology, and contemporary disability theology, the essay reconsiders how worship practices shape or exclude neurodiverse participation. By reframing sainthood through neurodiversity, the paper proposes that autistic presence in worship offers both theological insight and ecclesial renewal, calling the church toward adaptive practices of hospitality, holiness, and community that reflect the Spirit’s inclusive work.

Differences Of Sex Development (Dsd), Children's Mercy Kansas City

Clinical Pathways

No abstract provided.

Crispr-Cas9 Unleashed: Gene-Slicing Adventures In The Cancer Battlefield, Shivakuma Sonnaila, Shilpi Agrawal

Chemistry & Biochemistry Faculty Publications and Presentations

Cancer, a global health menace, continues to pose significant challenges in terms of incidence and mortality, necessitating innovative therapeutic strategies. Despite existing treatments, the limitations persist, prompting a quest for novel approaches. The emergence of immunotherapy marked a transformative era in solid tumor treatments, yet its efficacy is constrained by adverse effects. Concurrently, the integration of advanced technologies into cancer treatment explores the vast potential residing at the molecular level through gene analysis and manipulation. This review articulates the role of state-of-the-art genome editing technology, notably clustered regularly interspaced short palindromic repeats (CRISPR-Cas9), in overcoming the constraints of immunotherapy for …

The Surveillance Of System-Adjacent Individuals, Mariam A. Hinds

Faculty Scholarship

Although the Fourth Amendment protects against “unreasonable searches and seizures,” this right is not enjoyed by all people equally. Supreme Court jurisprudence has curtailed the Fourth Amendment privacy rights of individuals under probation or parole supervision. In this line of cases, the Court concluded that the government’s interest in monitoring supervisees, reducing recidivism, and promoting public safety outweighed their reasonable expectation of privacy.

However, surveillance mechanisms like probation and parole extend the criminal legal system’s carceral gaze beyond the supervisees and peer into the bedrooms and digital lives of their families, roommates, and communities, or who this Article calls system-adjacent …

Untangling Ai Openness, Parth Nobel, Alan Z. Rozenshtein, Chinmayi Sharma

Faculty Scholarship

The debate over AI openness—whether to make components of an artificial intelligence system available for public inspection and modification—forces policymakers to balance innovation, democratized access, safety and national security. By inviting startups and researchers into the fold, it enables independent oversight and inclusive collaboration. But technology giants can also use it to entrench their own power, while adversaries can use it to shortcut years and billions of dollars in building systems, like China’s Deepseek-R1, that rival our own. How we govern AI openness today will shape the future of AI and America’s role in it.   Policymakers and scholars grasp the …

An Empirical Study Of Malingering In Insanity Cases Across Twelve Decades, Deborah W. Denno

Faculty Scholarship

The last 120 years have seen a surge in the use of neuroscientific evidence in American criminal law cases, fueled by discoveries in brain science that have challenged the legal system’s assumptions about human thinking and culpability. One key assumption is that many defendants “malinger,” that is, feign or fake insanity or mental illness, to garner an acquittal or mitigated punishment. Likewise, when potential evidence that a defendant is malingering is introduced in court, it can have a pronounced and powerful negative effect on the defendant’s insanity claim, especially when juries and criminal justice actors are already skeptical of insanity …

The One-Stop-Shop Is One Step In The Right Direction, Olivier Sylvain

Faculty Scholarship

In Brokering Safety, Sharma, Kadri, and Adler urge federal policymakers to impose on data brokers the greater duty of policing and stemming online stalking, harassment, and related abuse; that burden should not fall to victims, they argue. Their proposal would close the unevenness among state laws, shift the burden of oversight away from victims, and, importantly, ensure accountability at a systemic level, addressing gaps in enforcement that allow brokers to evade meaningful consequences. Yet, the one-stop-shop solution that Brokering Safety proposes also accedes to the core neoliberal presumption insofar as it individualizes harm. Online abuse, like dark patterns and …

Beyond Numbers: Bridging Statistical Significance And Clinical Relevance In Healthcare Research, Maharaj Singh, Waheeda Khan, Mehreen Fatima

College of Nursing Faculty Research and Publications

Objective: This study aims to bridge the gap between statistical significance and clinical relevance using rigorous statistical methodologies applied to simulated healthcare data, thereby enhancing the translational value of research outcomes for patient‑centered care. Methods: A synthetic dataset representing 10,000 patients was generated, and descriptive statistics were applied to compare two treatment groups. Binary outcomes were predicted using both a logistic regression model and a neural network. Two‑tailed tests with a significant level of 0.05 were employed, utilizing SAS version 9.4 and IBM SPSS Statistics, Version 29.0 (IBM Corp., Armonk, New York, United States of America). Results: The simulated dataset …

Artificial Intelligence And Mental Health: Promise, Pitfalls And Ethical Priorities, Maharaj Singh

College of Nursing Faculty Research and Publications

Mental health conditions are prevalent across the lifespan, yet workforce shortages, long waiting times, and fragmented systems mean many people never receive timely, evidence‑based care. Artificial intelligence (AI), including machine‑learning classifiers and large language models (LLMs), is being explored to support earlier detection, closer symptom monitoring and scalable psychoeducation. Early studies suggest AI can surface risk signals from language, sleep/activity traces and clinical notes; summarise complex records for clinicians; and deliver structured self‑help at scale. At the same time, safety, bias, privacy and accountability concerns remain salient.

Positive Cosmology: On The Good Creation Into Which Christ Incarnated, Jason Horstman

The Asbury Journal

This article argues that a positive cosmology has been the majority report in the Christian tradition, which is to say that creation is good. Evidence of this report is highlighted from scripture, from the contemplative tradition, and from the hospitality tradition. Sin as a complicating factor in understanding creation as good is engaged, and a solution to this complication from the Christian monastic tradition is considered.

Comparing Us Medicare Coverage Options As A Contributing Mechanism To Sticking Or Switching To An Insurance Plan, Lisa M. Grabert, Brian J. Miller, Kathryn L. Wagner

College of Nursing Faculty Research and Publications

Background

In 2025, the US Medicare program is expected to spend over $1.1 trillion taxpayer dollars. A growing trend in the US Medicare program is more beneficiaries electing a private insurer, referred to as Medicare Advantage (MA), to manage their care. Since 2023, a slight majority of Medicare beneficiaries have elected to enroll in MA, yet little is understood about the mechanisms that drive beneficiaries toward their choices.

Methods

Our objective was to examine the association between comparing coverage options and ‘switching’ or ‘sticking’ with Fee-for-Service (FFS) Medicare or Medicare Advantage (MA). We conducted a panel study, using data from …

From The Goodness Of Our Hearts: A Scoping Review Of Qualitative Literature On Altruism As A Reward Mechanism For Nursing, Jacqueline Christianson, Madaline Mccarthy, Bonnie Sommers-Olson, Emily Horner, Norah L. Johnson

College of Nursing Faculty Research and Publications

Introduction

Altruism, the desire to help others, is a common motivation for choosing a career in nursing. Improved understanding of the role of altruism as a reward or motivation for currently-practicing nurses may inform future interventions to improve effort-reward balance among practicing nurses. Therefore, the purpose of this study was to collect, examine, and present literature on how altruism has been described as a reward mechanism or motivation for engaging in professional nursing.

Methods

This scoping review of literature used the Arksey & O’Malley method, PRISMA-ScR reporting checklist, and Rayyan review management platform. PubMed, Web of Science, and CINAHL were …

Impact Of Cigarette Smoke On Immune And Stromal Cells, Justin Wong

Master's Projects

Cigarette smoke is a plight on human health, being a major contributor to lung diseases. The aryl hydrocarbon receptor (AHR) directs immune regulation and metabolic adaptation in response to environmental toxins. This study investigates transcriptomic changes between wild-type and AHR knockout mouse lung tissue under smoke and air conditions. Single-cell RNA sequencing data were generated by the Butcher Lab and analyzed in Seurat for differential gene expression (DGE) analysis. A two way ANOVA framework was used with DGE analysis to classify genes as smoke induced or suppressed in an AHR dependent or independent manner, and these gene sets were analyzed …

Searching For Cause Of Unexplained Protein Interaction With Multiple Assembly Methods, Gavin Anderson

Master's Projects

Research into colistin adjuvants has identified interactions between a host of proteins and proteins found within certain strains of bacteria. BLAST, a widely adopted local sequence alignment tool, was used to create a database containing the genomes of relevant bacterial strains, which would then be used to query against the previously identified proteins. Many of these strains do not have publicly available assemblies, which makes database construction difficult. CATwalk, a new naïve fragment extender, is first described in this paper and used to extend fragments of interest. BLAST results first identified short fragments with sufficient similarity, which can then be …

Detection And Characterization Of Cancer Using Cfdna Fragmentomic Analysis, Guneet Bhogal

Master's Projects

Cell-free DNA (cfDNA) fragmentomics has emerged as a promising non-invasive approach for detecting and characterizing cancer by analyzing DNA fragmentation patterns. These fragment patterns are unique and can be used to distinguish between tumor and healthy DNA. This paper uses machine learning models to detect cancer by evaluating Shannon entropy of fragment lengths at the first coding exon 1 regions and correlating them to targeted cancer genes. This approach was applied to two datasets consisting of samples with prostate, breast, and lung cancers. Our results indicated that exon 1 fragmentation entropy captures biologically relevant differences in cancer-specific chromatin organization and …

Combining Crispr And Nanoasv To Uncover The Rare Bacterial Communities Of The Human Oral Microbiome, Gilma Ruth Sevilla Alvarez

Master's Projects

Studying the oral microbiome is vital because its health implications are not contained to the mouth. Cariogenic bacteria cause tooth demineralization and oral microbes that translocate to extra-oral organ systems are linked to conditions like Alzheimer’s disease, heart disease, diabetes, and cancer. Some of these pathogens belong to the most abundant phyla in the oral cavity: Bacillota, Pseudomonadota, Bacteroidota, Actinomycetota, Spirochaetota, and Fusobacteriota, which together comprise 94% of the oral microbiome. This project uses CRISPR-Cas9 to deplete sequences from highly abundant phyla and the Eubacteria domain, enriching the remaining 6% of rarer taxa. Paired with NanoASV for single-nucleotide resolution, this …

Multimodal Emotion Detection System, Shubhankar Sameer Munshi

Master's Projects

Trying to understand emotion from speech is a problem that is present in human computer interaction. Nevertheless, there are still some shortcomings in current SER methods. Text-based systems may miss vital vocal cues, such as sarcasm, tone changes, and delivery. On the other hand, purely audio-based systems are prone to noise and unstable acoustic features. The combination of linguistic and acoustic features in multimodal approaches partially solves this problem, but many existing approaches use inflexible multimodal fusion techniques that cannot adjust their behaviors according to the quality of input signals. In this work, we propose a multimodal approach based on …

Healthcare Transition In Spina Bifida: A National Mixed Method Study, Betsy Hopson, Kathy H Huen, Molly B Richardson, Rhonda G Cady, Jennifer T Queally, Judy Thibadeau, Ellen Fremion

Faculty, Staff and Students Publications

Introduction: Adolescents and young adults (AYA) with spina bifida (SB) face substantial challenges during the transition from pediatric to adult healthcare, including fragmented systems, limited adult provider availability, and gaps in self-management readiness. Despite national guidelines, little is known about how transition practices are implemented across the Spina Bifida Association (SBA) Clinical Care Partner (CCP) network. This study examined clinician perspectives on current practices, barriers, facilitators, and definitions of successful healthcare transition (HCT).

Methods: Using an explanatory sequential mixed methods design, we first conducted a 47-item survey with clinicians from SBA CCP clinics (n = 20/32; 62.5 % response rate). …

Safety And Efficacy Of Vadadustat Versus Darbepoetin Alfa For Chronic Kidney Disease-Related Anemia In Patients Receiving Dialysis By Baseline Erythropoiesis-Stimulating Agent Dose, Alan Jardine, Steven K Burke, Wenli Luo, Todd Minga, Mark J Sarnak, Wolfgang C Winkelmayer, Rajiv Agarwal, Glenn M Chertow, Kai-Uwe Eckardt, Mark J Koury

Faculty, Staff and Students Publications

Introduction: Erythropoiesis-stimulating agents (ESAs) and iron supplementation are standard treatments for chronic kidney disease (CKD)-related anemia. Targeting higher hemoglobin values in CKD increases cardiovascular risk. Whether the increased risk is from higher ESA doses or higher hemoglobin levels is uncertain, but alternative therapies are sought for patients requiring high ESA doses. Phase 3 INNO2VATE trials in patients with dialysis-dependent CKD (DD-CKD) demonstrated vadadustat's noninferiority compared with darbepoetin alfa. To determine vadadustat's potential to treat anemia, including in patients requiring high ESA doses, its safety and efficacy were compared with those of darbepoetin alfa across prespecified baseline ESA dose subgroups in …

A Review Of Current Research And Barriers To Access: Exploring Disparities In Pediatric Epilepsy Surgery, Nikita Das, Ali A Mohamed, Akshat Katyayan, Meena Vessell

Faculty, Staff and Students Publications

Background: Drug-resistant epilepsy (DRE) impacts at least 30% of pediatric epilepsy patients, adversely affecting neurodevelopment and quality of life, as well as risk of sudden unexplained death in epilepsy (SUDEP). While surgical intervention has proven to be an effective treatment for DRE, disparities in access to surgical care persist. Compared to adults, pediatric patients face unique challenges, including delayed recognition of surgical candidacy, limited access to specialized epilepsy centers, complex care coordination, and socioeconomic barriers.

Summary: This review explores the current state of pediatric epilepsy surgery, highlighting its effectiveness in achieving seizure freedom, improving neurocognitive outcomes, and reducing long-term healthcare …

Phase I Study Of Niraparib With Radiotherapy For Treatment Of Metastatic And Locally Advanced Invasive Carcinoma Of The Cervix (Nivix), Piyush Pathak, Eunji Jo, Susan Hilsenbeck, Matthew L Anderson, Alfredo Echeverria, Shelly Sharma, Jan Sunde, Tracilyn Hall, Anthony Costales, Claire Hoppenot, Michelle Ludwig

Faculty, Staff and Students Publications

Introduction: This Phase I study evaluated the safety and tolerability of concurrent niraparib, an oral poly(ADP-ribose) polymerase (PARP) 1/2 inhibitor, with definitive radiotherapy in women with locally advanced or platinum-sensitive metastatic cervical cancer. Dose escalation followed a Bayesian Optimal Interval (BOIN) design with a target dose-limiting toxicity (DLT) rate of 30%.

Methods: Women ≥18 years with FIGO stage IIIC2 (bulky nodes >1 cm) or stage IV cervical cancer demonstrating response to platinum-based induction chemotherapy were eligible. Niraparib 100 mg was administered daily concurrent with pelvic radiotherapy (45-57.5 Gy via IMRT with nodal boosts) and brachytherapy, continuing 28 days post-radiation. Per …