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2026

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Authorship Nonsense, Jessica Litman Jan 2026

Authorship Nonsense, Jessica Litman

Articles

Copyright law’s primary device for promoting progress is to bestow rights on the authors of works. Rights vest automatically and last for a very long time. Authors’ choices to retain, license, or transfer those rights fuel opportunities to communicate the works to their audiences. The copyright system’s mechanisms for determining who authored works (and therefore automatically obtained copyright rights) should be both accurate and reliable, since misidentifications will undermine the law’s working as intended.

This article examines authors’ creation of works and copyright law’s handling of authorship disputes. Many works result from creative collaboration. Although the copyright statute incorporates mechanisms …


Monitoring, Oversight, And Learning In Medical Ai, W. Nicholson Price Ii Jan 2026

Monitoring, Oversight, And Learning In Medical Ai, W. Nicholson Price Ii

Articles

When medical AI errs, it often goes unnoticed. If there’s a specific patient injury, and the link to AI is obvious, that problem might be reported to the Food and Drug Administration (FDA), but not always. And many other types of problems, like worse performance on specific groups or ineffective integration into health system workflows, simply don’t fall within the contours of regularized reporting. Even if they are noticed by the health system—far from a given—there’s no obvious way to share that information more broadly. Against this backdrop, there are justified calls for better oversight and reporting. But there’s the …


Read But Not Understood? An Empirical Analysis Of Consumer Comprehension In Homeowners Insurance, Daniel Schwarcz, Brenda J. Cude, Kyle D. Logue, German Marquez Alcala Jan 2026

Read But Not Understood? An Empirical Analysis Of Consumer Comprehension In Homeowners Insurance, Daniel Schwarcz, Brenda J. Cude, Kyle D. Logue, German Marquez Alcala

Articles

Modern contract law assumes that consumers meaningfully assent to the standard forms that govern their daily lives. However, this assumption is widely regarded as a legal fiction for two key reasons: first, most consumers do not read standard forms, and second, even those who do often struggle to fully comprehend their terms and implications. Although the lack of consumer reading has been well documented through empirical research, consumers’ ability to comprehend standard-form contracts has received surprisingly little attention.

This Article addresses the latter issue by empirically examining whether providing excerpts from the dominant standard-form homeowners insurance policy improves consumer understanding …


The Basis Of The Labor Exemption Reconsidered, Sanjukta Paul Jan 2026

The Basis Of The Labor Exemption Reconsidered, Sanjukta Paul

Articles

Broadly speaking, this symposium queries the question of expanding some actors’ coordination rights under antitrust law as a way of effectuating legal goals relating to “power relations.” I commend the organizers of the symposium for opening this conversation, for asking about the use of “collective bargaining” beyond the traditional labor domain, and for taking on the question in a creative way. These broader questions are essential, and yet my own article will (paradoxically, perhaps) try to contribute to this effort by going back to the core domain of the labor exemption itself—where, it turns


Covid And The Great Retrenchment, Samuel R. Bagenstos Jan 2026

Covid And The Great Retrenchment, Samuel R. Bagenstos

Articles

The past six years have seen two dramatic shifts in federal health and benefits policy. First, during the COVID pandemic, the government dramatically expanded public benefits. These expansions had incredibly positive effects, and recipients were largely satisfied with them. But after a relatively short time, Congress rolled back nearly all of the expansion. Worse, the immediate pullback set the stage for even more significant retrenchments in the second Trump Administration. Where in 2023 the United States came closest to universal health care in its history—with a record low uninsured rate of 7.7%—the Trump Administration’s Medicaid cuts and failure to extend …


Useful Noise: Understanding Dicta And Knowing What To Do With It, Len Niehoff, Tucker Gribble Jan 2026

Useful Noise: Understanding Dicta And Knowing What To Do With It, Len Niehoff, Tucker Gribble

Articles

Sometimes we approach the idea of obiter dictum as if it were Latin for “Here the court says something I wish it didn’t.” When a judicial opinion includes a statement that hurts our case, we labor to cast it as dicta and we give it the first name “mere.” If the opposing party quotes the statement, we huff about its irrelevance and dismissively proclaim that it can, indeed must, be ignored. We treat dicta as background noise, and we encourage the court to plug its ears and hum.


Junior Public Health Service Officer Mentor Program: Developing New Leaders In The United States Public Health Service Commissioned Corps For Workforce Retention, Felecia Annetta Bailey Jan 2026

Junior Public Health Service Officer Mentor Program: Developing New Leaders In The United States Public Health Service Commissioned Corps For Workforce Retention, Felecia Annetta Bailey

Yale School of Nursing Digital Theses

Junior Public Health Service Officer Mentor Program: Developing New Leaders in the United States Public Health Service Commissioned Corps for Workforce Retention

Mentorship is a critical tool for preparing junior personnel for senior roles, professional development and retention within organizations; however, formal mentorship is often lacking or insufficiently tailored to the needs of diverse workforces, particularly in organizations comprising uniformed service members and civilian employees. This project was designed to provide targeted mentorship for Public Health Service (PHS) Commissioned Corps junior officers and to modify an existing mentoring program that primarily served civilian personnel.

The project aimed to modify the …


Optimization Of Social Determinants Of Health Data With Z Code Utilization In Inpatient Care, Felicia Cordia Alleyne Jan 2026

Optimization Of Social Determinants Of Health Data With Z Code Utilization In Inpatient Care, Felicia Cordia Alleyne

Yale School of Nursing Digital Theses

The U.S. healthcare system is characterized as being costly, wasteful, and fraught with inequity, due to historical disparities and contemporary challenges such as the aftermath of the COVID 19 pandemic and recent international policy changes that raise the costs of materials and imports. There is evidence to support that with the use of social determinants of health screening tools that are associated with a standardized data capture approach can contribute to value-added clinical and financial changes, resulting in improve care, reduce healthcare disparities, and reduce healthcare costs. This DNP project piloted the implementation of a training protocol for a social …


Nursing Primary Care To Better Health, Kristen Dulling Jan 2026

Nursing Primary Care To Better Health, Kristen Dulling

Yale School of Nursing Digital Theses

The national nursing shortage and the rising cost of nursing is threatening sustainability of

the RN role on the care team in ambulatory care settings. There is a critical need to develop a

care model that defines the value of RNs on the primary care team by improving access and

effectively reducing cost by mitigating turnover and role dissatisfaction. This DNP project

developed and implemented a care model across four primary care settings that shifted

workflows for vaccine administration, prior authorizations, and emergency department follow up

calls from RNs to other roles on the care team. Capacity created allowed the …


Addressing Social Determinants Of Health To Reduce Missed Appointments In Primary Care Setting., Omolara Goyea Jan 2026

Addressing Social Determinants Of Health To Reduce Missed Appointments In Primary Care Setting., Omolara Goyea

Yale School of Nursing Digital Theses

Background: Missed appointments impose a significant financial burden on the U.S. healthcaresystem, costing over $150 billion annually, with individual physicians losing an average of $200 per unused time slot (Gier, 2017). Unmet Social Determinants of Health (SDOH), such as transportation barriers, negatively impact primary care services and contribute to missed appointments (Brown et al., 2020; Fiori et al). The missed appointment rate in the United States ranges from 12% to 50% of scheduled appointments (Boone et al., 2023). Objective: This quality improvement project aimed to develop, implement, and evaluate a telehealth protocol specifically tailored for patients who identified transportation as …


The Effect Of Polypharmacy On Nurse’S Workflow And Healthcare Expenditure In Post-Acute Care, Rachel Hudec Jan 2026

The Effect Of Polypharmacy On Nurse’S Workflow And Healthcare Expenditure In Post-Acute Care, Rachel Hudec

Yale School of Nursing Digital Theses

This DNP project modified a deprescribing initiative to engage frontline nursing staff. The intervention included a comprehensive educational curriculum, clinical guidelines, and a system to track nurse workflow and financial metrics. Guided by Donabedian’s conceptual model, the project was piloted in a large municipal PAC facility. Methods included twelve in-person training sessions for 93 nurses, pre- and post-knowledge tests, a program evaluation, medication pass times, and tracked the costs deprescribed medications over six months.Nursing knowledge significantly improved, with mean test scores rising from 41.39 to 90.64 (p < .001). Medication pass decreased by 18%, reducing the time per resident from 7 to 5.7 minutes. Financially, the initiative saved over $21,000 in six months, with a projected annual savings exceeding $42,000. Integrating nurses as leaders in deprescribing enhances clinical competency and operational efficiency. These findings provide a compelling case for standardizing an interdisciplinary deprescribing program to improve financial sustainability, nursing efficiency and resident safety in the PAC setting.


Nurturing Novice Nurse Development Through The Legacy Mentor Model: Building The Infrastructure And Stabilizing The Workforce In A Healthcare System, Maureen Scanlan Jan 2026

Nurturing Novice Nurse Development Through The Legacy Mentor Model: Building The Infrastructure And Stabilizing The Workforce In A Healthcare System, Maureen Scanlan

Yale School of Nursing Digital Theses

There is a historically high nurse turnover rate with a limited supply of experienced registered nurses across healthcare organizations. The retirement of senior nurses, referred to as Legacy Mentors, leaves inexperienced ones without valuable support and guidance. This project aimed to implement and evaluate a mentorship program to improve intent to stay among novice nurses in their first year of practice in an acute care setting. The novice nurses were paired with Legacy Mentors. A total of 32 nurses participated in 16 mentee/mentor pairs. The program consisted of six one-hour sessions over three months, which focused on wisdom sharing, community …


Implementing Hepatitis C Screening And Treatment In Primary Care, Michele Castellano Wetmore Jan 2026

Implementing Hepatitis C Screening And Treatment In Primary Care, Michele Castellano Wetmore

Yale School of Nursing Digital Theses

AbstractHepatitis C (HCV) is a curable hepatic disease. With direct-acting antivirals, it can be treated in 95% of cases. When left untreated, it can cause severe liver disease, including hepatocellular carcinoma and even death. The World Health Organization’s (WHO) goal is to eliminate HCV by 2030. This Quality Improvement (QI) project, conducted at a Federally Qualified Health Center (FQHC) from 8/4/2025 to 11/4/2025, will address the barriers to elimination and show that providing local services closes gaps. Screening and treating HCV within primary care has become a strategic approach to enhance access to treatment. This involves developing and utilizing a …


The Effect Of Verbal De-Escalation Simulation Training Using Artificial Intelligence On Nurse Leader’S Self-Efficacy, Mary Vitullo Jan 2026

The Effect Of Verbal De-Escalation Simulation Training Using Artificial Intelligence On Nurse Leader’S Self-Efficacy, Mary Vitullo

Yale School of Nursing Digital Theses

Per year, rates of verbal workplace violence (V-WPV) are estimated to occur in 38.8 per 100 nurses, which is decreasing leader retention (NIOSH, 2020, Chang, Hsu, & Ouyang, 2022). Increasing the confidence of nurses in handling V-WPV through simulated training programs increases their intent to stay (Ming et al., 2019).

A two-pronged training program allowed nurse leaders to learn de-escalation techniques and then apply that knowledge in a life-like simulated environment. The education included a pre-work module on V-WPV de-escalation and a simulated scenario using an artificial intelligence conversational agent.

The aims of the project were: to develop a model, …


Exploring Parent-Child Reminiscing Style And Internal-State Talk When Discussing Positive And Negative Shared Events, Komal Verma Miss. Jan 2026

Exploring Parent-Child Reminiscing Style And Internal-State Talk When Discussing Positive And Negative Shared Events, Komal Verma Miss.

Theses and Dissertations (Comprehensive)

Conversations between parents and children about past events play a critical role in children’s social, emotional, and cognitive development. Parents scaffold their children in learning to recount details of their autobiographical memories by creating a space to reflect on internal states, specifically emotions and cognitions. Parents with an ‘elaborative’ reminiscing style are responsive to children’s utterances and ask open-ended questions (e.g., What do you remember about...?). Parents who are less ‘elaborative’ typically ask narrow questions like Did you like it?” that do not encourage conversation. Children whose parents use an elaborative reminiscing style have children who produce the most detailed …


Nanoparticle Carriers Enhance The Prophylactic Antiviral Effects Of Dsrna In Vitro And Ex Vivo, Shayne Oberhoffner, Stephanie Dewitte-Orr, Starla Richardson, Leah Haile, Dominique Daniels, Erin Cooper, Aizah Ijaz, Janet Velasquez Perez, Mathilde Peruzzi, Bertrand Collet, Paul Craig, Kristof Jenik Jan 2026

Nanoparticle Carriers Enhance The Prophylactic Antiviral Effects Of Dsrna In Vitro And Ex Vivo, Shayne Oberhoffner, Stephanie Dewitte-Orr, Starla Richardson, Leah Haile, Dominique Daniels, Erin Cooper, Aizah Ijaz, Janet Velasquez Perez, Mathilde Peruzzi, Bertrand Collet, Paul Craig, Kristof Jenik

Theses and Dissertations (Comprehensive)

Aquaculture now outpaces traditional capture fisheries as the world population and demand for sustainable protein sources increases. Wild and farmed species are increasingly susceptible to pathogen spread as global temperatures rise and stocking densities increase. Despite the devastating losses experienced by aquaculture due to viral infections, there remain few effective prophylactic antiviral therapeutics. Long double-stranded (ds)RNA is a uniquely viral molecule produced by nearly all viruses during their replication cycle, and its detection by salmonids like rainbow trout (Oncorhynchus mykiss) and chinook salmon (Oncorhynchus tshawytsha) leads to the establishment of a defensive antiviral state. Previous in vitro studies demonstrated a …


Adapting To Uncertainty: Effects Of Environmental Instability On Zebrafish Behaviour, Britney Sekulovski Jan 2026

Adapting To Uncertainty: Effects Of Environmental Instability On Zebrafish Behaviour, Britney Sekulovski

Theses and Dissertations (Comprehensive)

This thesis addresses how animals cope with unpredictability by testing how environmental stability changes the behaviour of zebrafish (Danio rerio) in two complementary experiments. In Experiment 1, fish lived for three months in either a Dynamic environment (water temperature, feeding times, habitat complexity, group size, and membership fluctuated) or a Stable environment (all factors constant). Across seven behavioural assays, measuring individual behavioural differences, collective movement, social memory, and information use, Dynamic condition fish were found to be more sensitive to social cues and more likely to conform to recent social information, independent of the quality of the information …


Neural Correlates Of Cognitive Fatigue In Regular Cannabis Users And Non-Users: A Pilot Fnirs Study, Mariia Vistyzenko Jan 2026

Neural Correlates Of Cognitive Fatigue In Regular Cannabis Users And Non-Users: A Pilot Fnirs Study, Mariia Vistyzenko

Theses and Dissertations (Comprehensive)

Background: Cognitive fatigue impairs performance across multiple domains, yet how regular cannabis use affects fatigue responses remains unclear. This pilot study investigated neural and behavioural correlates of cognitive fatigue in abstinent cannabis users versus non-users.

Methods: Twenty-six participants (18 non-users, 8 regular cannabis users after 24-hour abstinence) completed cognitive tasks before and after a 60-minute Sustained Attention to Response Task (SART) designed to induce fatigue. Tasks assessed working memory (N-Back), cognitive flexibility (Wisconsin Card Sorting), psychomotor speed (Digit Symbol Substitution), sustained attention (Continuous Performance Task), inhibition (Stroop, Stop Signal), and motion perception. Functional near-infrared spectroscopy (fNIRS) continuously monitored prefrontal cortex …


Envisioning The Role Of Community-Owned Stores & Aligning Federal Food Policies: A Participatory Approach To Food Security And Food Sovereignty In Sambaa K’E, Denendeh (Northwest Territories, Canada), Narayan Subramoniam Jan 2026

Envisioning The Role Of Community-Owned Stores & Aligning Federal Food Policies: A Participatory Approach To Food Security And Food Sovereignty In Sambaa K’E, Denendeh (Northwest Territories, Canada), Narayan Subramoniam

Theses and Dissertations (Comprehensive)

Northern Indigenous communities have relied on traditional food systems for meaningful, nutritious diets since time immemorial. But many Indigenous communities in remote northern regions of Canada still face disproportionately elevated levels of food insecurity due to climate change radically altering the availability for traditional foods, colonial food policies imposing Western diets, and the high costs of transporting store-bought foods. Extreme weather events such as wildfires further isolate fly-in remote communities increasing both the costs of transporting store-bought foods and the difficulties of harvesting traditional foods. There are many examples of community-based initiatives for supporting traditional and locally grown foods, however, …


Investigating The Impact Of Winter Exposure To Natural Environments On Perceived Health And Well-Being Using Geographic Ecological Momentary Assessment: A Case Study At Arrowhead Provincial Park, Faith M. Laing Jan 2026

Investigating The Impact Of Winter Exposure To Natural Environments On Perceived Health And Well-Being Using Geographic Ecological Momentary Assessment: A Case Study At Arrowhead Provincial Park, Faith M. Laing

Theses and Dissertations (Comprehensive)

This study examined how winter exposure to specific natural environments influenced perceived health and well-being outcomes using Geographic Ecological Momentary Assessment (GEMA) in Arrowhead Provincial Park. Studies performed in the wintertime are limited, as is our understanding of how specific park features and/or activities impact health and well-being. To address this, GEMA was used with a video component to capture participants’ real-time experience and emotional responses in specific park locations defined by polygon boundaries. Two surveys were administered through participants mobile devices, one being an in-situ engagement survey triggered by entering a bounded location, which included a video and …


Injury To Insight: Exploring The Influence Of Media On Acl Rehabilitation Experiences Of Female Soccer Players, Chynna Ho-Young Cadogan, Jill Tracey Jan 2026

Injury To Insight: Exploring The Influence Of Media On Acl Rehabilitation Experiences Of Female Soccer Players, Chynna Ho-Young Cadogan, Jill Tracey

Theses and Dissertations (Comprehensive)

Participation in soccer inherently carries a risk of injury, with female athletes facing a significantly higher susceptibility to anterior cruciate ligament (ACL) injuries (Campbell et al., 2014; Le et al., 2025; Silvers-Granelli, 2021). The increasing participation in women’s soccer, coupled with the growing demand for its consumption through spectatorship, has contributed to a rise in ACL injuries, and increase in media coverage on this phenomenon (Parsons et al., 2021). Understanding how media narratives surrounding ACL injuries and recovery may influence rehabilitation experiences can educate coaches, mental performance consultants, athletic therapists, and female soccer players to better understand and navigate ACL …


Autism And Homelessness: An Intersectional Case Study In Kitchener-Waterloo, Ontario, Nicole J. Mcdonald Jan 2026

Autism And Homelessness: An Intersectional Case Study In Kitchener-Waterloo, Ontario, Nicole J. Mcdonald

Theses and Dissertations (Comprehensive)

Homelessness is a growing crisis in Canada, with literature suggesting autistic traits as over-represented within this population. Literature addressing intersectional experiences of autism is emerging, however there are gaps in the research surrounding intersectional experiences of autism and homelessness. Research suggests that autistic individuals may be more vulnerable to experiencing homelessness and face difficulties in exiting homelessness. This qualitative case study utilizes a Disability Justice framework to explore intersectional autistic experiences of homelessness, social service usage, and suggests recommendations on improving support for autistic individuals at risk of and experiencing homelessness. Four autistic participants with experience of homelessness and accessing …


At A Crossroads: Crisis, Vulnerability, And The Possibility Of Transformation Of Nature-Based Tourism In Canada, Brooklyn Rushton Jan 2026

At A Crossroads: Crisis, Vulnerability, And The Possibility Of Transformation Of Nature-Based Tourism In Canada, Brooklyn Rushton

Theses and Dissertations (Comprehensive)

We live in an era shaped by a global polycrisis, where climate change, pandemics, economic shocks, geopolitical tensions, and social inequities are converging to create complex, cascading, and compounding risks. For Canada’s nature-based tourism sector, situated at the nexus of social and ecological systems, the polycrisis both amplifies the vulnerabilities of tourism and highlights tourism’s role in perpetuating global risks. Recognizing this duality, this dissertation examines how crises amplify systemic vulnerabilities while also acting as leverage points for transformative change in Canada’s nature-based tourism sector, drawing on geography, systems thinking, resilience theory, regenerative tourism, and futures thinking scholarship.

The three …


Cognitive Load Classification Using Functional Near-Infrared Spectroscopy, Pratham Shah Jan 2026

Cognitive Load Classification Using Functional Near-Infrared Spectroscopy, Pratham Shah

Theses and Dissertations (Comprehensive)

This thesis investigates the classification of cognitive load using functional near-infrared spectroscopy (fNIRS) signals recorded during an N-back working memory task. The study introduces a novel short-channel correction layer designed to suppress superficial physiological noise adaptively, addressing limitations of traditional General Linear Model (GLM) based regression. A single participant dataset comprising 69 validated sessions was analyzed using both conventional machine learning and deep learning approaches. Traditional classifiers: Linear Discriminant Analysis (LDA), Support Vector Machines (SVM), Random Forests, and Gradient Boosting were first evaluated using statistical features (mean, variance, peak, and slope). Among these, Gradient Boosting achieved the highest accuracy (55.6%), …


Unveiling Othering Experiences In Multiethnic Families: Narratives Of Identity And Belonging Among White/Hispanoamerican Women, Maria-Esther Wood Jan 2026

Unveiling Othering Experiences In Multiethnic Families: Narratives Of Identity And Belonging Among White/Hispanoamerican Women, Maria-Esther Wood

Theses and Dissertations (Comprehensive)

This dissertation explores the lived experiences of multiethnic Hispanoamerican women as they navigate identity, belonging, and familial othering within the context of multiethnic family systems. Using qualitative narrative inquiry, the study centres the voices of nine women residing in Ontario, each with one white parent and one Hispanoamerican parent, ranging in age from 19 to 65. Guided by Dewey’s three-dimensional model of narrative analysis, the research explores how personal stories reflect broader patterns of othering and belonging, the central research question asks: What specific forms of othering related to identity and belonging—inclusive of discrimination and racist treatment—do multiethnic Hispanoamerican women …


A Contribution To Constructing A Theory And Model Of Social Work Leadership, Cheri Darlene Bilitz Jan 2026

A Contribution To Constructing A Theory And Model Of Social Work Leadership, Cheri Darlene Bilitz

Theses and Dissertations (Comprehensive)

Few schools of social work provide formal leadership education and training for emerging social workers—the research topic under exploration was how social work leaders constructed their leadership style. The purpose of the study was to develop a model of social work leadership through understanding leaders’ journeys into leadership and the contextual factors that shaped their leadership. Participants shared the qualities they believed were paramount for leading today and into the future. Seeing schools of social work as leadership incubators for emerging social workers, participants shared their suggestions for scaffolded leadership curriculum. The methodological approach for this research study was constructivist …


The Forgotten Carers: A Study Of The Lived Experiences Of Chinese Canadians Caring For A Family Member With Borderline Personality Disorder (Bpd/Fbpd), Judy Y.F. Wu Jan 2026

The Forgotten Carers: A Study Of The Lived Experiences Of Chinese Canadians Caring For A Family Member With Borderline Personality Disorder (Bpd/Fbpd), Judy Y.F. Wu

Theses and Dissertations (Comprehensive)

There is a fair amount of literature on Borderline Personality Disorder (BPD); however, it still lags behind research on other major mental illnesses such as depression and schizophrenia (Furnham et al., 2015). Similarly, while there has been ample research on caring from various perspectives; little has been explored regarding caring for individuals with BPD. Research on Chinese Canadian families caring for patients with BPD is even more scarce. This study explored the lived experiences of Chinese Canadians caring for family members diagnosed with BPD (FBPD) in the Greater Toronto Area (GTA), Ontario, Canada. BPD is characterised by “interpersonal hypersensitivity, affective …


Cultivating Diversity In Sustainable Food Systems: Black Farming And Lived Experience In Rural Southern Ontario, Kadeem Jerofy Morgan-Adamson Mr. Jan 2026

Cultivating Diversity In Sustainable Food Systems: Black Farming And Lived Experience In Rural Southern Ontario, Kadeem Jerofy Morgan-Adamson Mr.

Theses and Dissertations (Comprehensive)

This research examines the lived experiences of Black food growers in rural Southern Ontario to understand how their perspectives challenge dominant narratives of rurality and inform broader discussions on food sovereignty in Canada. Grounded in postcolonial theory, the study highlights how historical dispossession and persistent inequities shape the access of Black communities to land and resources. Using a mixed-methods approach that includes surveys, semi-structured interviews, and reflexive journaling within a community-based research framework, the study documents the barriers Black food growers face. These include limited land access, insufficient funding, inadequate training pathways, and experiences of racial isolation in rural contexts. …


Taylorkan-Vit: Parameter-Efficient Vision Transformers For Medical Image Classification, Kaniz Fatema, Dr. Emad Mohammed, Dr. Sukhjit Singh Sehra Jan 2026

Taylorkan-Vit: Parameter-Efficient Vision Transformers For Medical Image Classification, Kaniz Fatema, Dr. Emad Mohammed, Dr. Sukhjit Singh Sehra

Theses and Dissertations (Comprehensive)

Effective and interpretable classification of medical images remains a critical challenge in computer-aided diagnosis, particularly in data-scarce and resource-constrained clinical settings where traditional deep learning models prove impractical. This study addresses the fundamental barrier to Vision Transformer adoption in medical imaging—massive parameter counts and data requirements—through a systematic two-phase methodology. Phase 1 evaluates three spline-based Kolmogorov–Arnold Network (KAN) variants to identify the optimal nonlinear approximation function for parameter-efficient medical image classification: SBTAYLOR-KAN (B-splines with Taylor series), SBRBF-KAN (B-splines with Radial Basis Functions), and SBWAVELET-KAN (B-splines with Morlet wavelets). Comprehensive experiments across brain MRI, chest X-rays, and tuberculosis datasets—without any image …


Investigating The Immunostimulatory Potential Of Dsrna-Silk Nanoparticle Complexes In Melanoma, Samuel J. Peters Jan 2026

Investigating The Immunostimulatory Potential Of Dsrna-Silk Nanoparticle Complexes In Melanoma, Samuel J. Peters

Theses and Dissertations (Comprehensive)

The rate of resistance to immune checkpoint inhibitor treatment in metastatic melanoma is quite high, with an overall rate of 70%. Melanoma achieves these high rates of resistance by suppressing the immune response in the tumour microenvironment (TME), making them immunologically “cold”. The type 1 interferon response could be leveraged to initiate immune responses in melanoma, making their “cold” TMEs “warm” again. Double-stranded ribonucleic acids (dsRNAs) are potent activators of an innate immune response; however, they are susceptible to degradation by nucleases present in the body and need a carrier. Silk nanoparticles (SNPs) are an ideal drug-delivery platform as they …