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2026

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Netchoice V. Wilson, District Of South Carolina Jan 2026

Netchoice V. Wilson, District Of South Carolina

Historical and Topical Legal Documents

No abstract provided.


An Introduction For Nursing Research: An Open Educational Resource For The Undergraduate Nursing Student, Ellen Benjamin Jan 2026

An Introduction For Nursing Research: An Open Educational Resource For The Undergraduate Nursing Student, Ellen Benjamin

OER Textbooks

The purpose of this text is not to prepare you to independently conduct research, but to help you become an informed and critical consumer of research. The ability to systematically evaluate the strengths, limitations, and applicability of research findings is known as critical appraisal. Critical appraisal is an expected competency of baccalaureate-prepared nurses [5] and requires a foundational understanding of research principles and methods. This book will introduce the research process, including common research methodologies, data collection and analysis approaches, ethical considerations, and strategies for translating research evidence into nursing practice.


Bridging The Gap: A Systematic Review Of Cyber Conflict Forecasting Models And The Case For Ai-Driven Dynamic Frameworks, Salim Arfaoui, Youssef Harrath, Omar El-Gayar Jan 2026

Bridging The Gap: A Systematic Review Of Cyber Conflict Forecasting Models And The Case For Ai-Driven Dynamic Frameworks, Salim Arfaoui, Youssef Harrath, Omar El-Gayar

Research & Publications

Cyber conflict forecasting remains constrained by static models that overlook the integration of geopolitical context with technical indicators. This systematic literature review examines 58 studies (2010–2025) using PRISMA guidelines and an Input-Process-Output framework to classify approaches and identify key gaps. Quantitative methods dominate (67%), yet only 14% incorporate geopolitical variables, despite the political nature of cyber conflict. Major limitations include adversarial adaptation blindness (85% assume static behavior), coarse temporal granularity (72% use daily+ intervals), lack of uncertainty quantification (75%), and minimal modeling of cross-domain escalation (92% cyber-only focus). Strategic forecasting is rare, with just 14% providing long-term insights and 16% …


Multimodal Late-Fusion Of Radiomics, Clinical Data, And Demographics Enhances Personalized Survival Prediction In Nsclc, Zarindokht Helforoush, Mohamed Jaber, Nezamoddin N. Kachouie Jan 2026

Multimodal Late-Fusion Of Radiomics, Clinical Data, And Demographics Enhances Personalized Survival Prediction In Nsclc, Zarindokht Helforoush, Mohamed Jaber, Nezamoddin N. Kachouie

Mathematics and System Engineering Faculty Publications

Backgrounds/Objectives: Non-small cell lung cancer (NSCLC) exhibits substantial prognostic heterogeneity that is not fully captured by conventional anatomical staging, highlighting the need for individualized risk assessment. Radiomics enables non-invasive characterization of tumor phenotype, yet high dimensionality and inter-feature correlations often limit model stability and interpretability. Methods: To address these challenges, we developed a multimodal late-fusion framework integrating radiomic, clinical, and demographic information to predict patient-specific absolute risk in the Lung1 cohort (N = 398). Radomic features (N = 107) were extracted from primary tumor volumes and refined using a Group Lasso–penalized Cox model, preserving biological coherence and producing a parsimonious …


The Effects Of Expectancies And Attention To Placebo Relevant Sensations On The Open-Label Placebo Response, Miranda Connelly Jan 2026

The Effects Of Expectancies And Attention To Placebo Relevant Sensations On The Open-Label Placebo Response, Miranda Connelly

Cal Poly Humboldt theses and projects

Placebo analgesia has shown promise in treating pain, but practitioners are reluctant to prescribe deceptive placebos. Open-label, or honestly prescribed placebos, offer an ethical alternative. Open-label placebos seem to work largely through experimenter-manipulated expectancy, as well as social/environmental factors. Additionally, verbally guided attention to relevant placebo sensations might bolster pain relief. In the present study, expectancy and attention were experimentally manipulated within a 2 (expectancy: high/low) x 2 (attention: high/low) between-subjects design with a no-treatment comparison group. Pain was experimentally induced in all five experimental groups using the well-established cold pressor task. The primary dependent variables were pain tolerance and …


The Effect Of Automated Self-Monitoring On The Behavior Of Individuals Diagnosed With Pre-Diabetes Or Type 2 Diabetes, Leti Phillips Armenta Jan 2026

The Effect Of Automated Self-Monitoring On The Behavior Of Individuals Diagnosed With Pre-Diabetes Or Type 2 Diabetes, Leti Phillips Armenta

Cal Poly Humboldt theses and projects

Type 2 diabetes (T2D) and prediabetes affect millions of individuals in the United States and require effective self-management strategies to reduce glucose variability and improve health outcomes. This study evaluated the effects of automated self-monitoring using the Dexcom G7 continuous glucose monitor (CGM) on glucose management and health-related behaviors among adults diagnosed with prediabetes or at risk for T2D. A repeated-measures design was used to asses’ participants across two distinct 10-day periods. Data included CGM glucose readings, self-report questionnaires, and social validity measures. Results indicated that participants demonstrated reduced glucose variability, fewer prolonged glucose spikes, and increased engagement in health-related …


Land Cover Classification Using Optimized Imagery Resolution And Machine Learning Algorithms For A Long-Term Monitoring And Restoration Project, Jessica R. Suoja Jan 2026

Land Cover Classification Using Optimized Imagery Resolution And Machine Learning Algorithms For A Long-Term Monitoring And Restoration Project, Jessica R. Suoja

Cal Poly Humboldt theses and projects

Ecosystem services and functions are prone to water resource exploitation resulting in cascading effects that include decrease of biodiversity and loss of riparian vegetation, a keystone habitat in desert riparian ecosystems. Mono Lake is a prime example of overexploitation of water resources leading to legal action and eventually a legally mandated long-term monitoring and restoration project. Monitoring and restoration projects can benefit from techniques such as remote sensing and machine learning algorithms to generate accurate land cover classification maps for calculating land cover change over time. However, the spatial resolution of remote sensing imagery and the machine learning algorithms chosen …


The Spatial Relationship Between The Residents Of Buttonwillow, Ca And The Carbon Capture And Storage Project, Carbon Terravault, Daniell Dorado Jan 2026

The Spatial Relationship Between The Residents Of Buttonwillow, Ca And The Carbon Capture And Storage Project, Carbon Terravault, Daniell Dorado

Cal Poly Humboldt theses and projects

Carbon capture, utilization and storage (CCUS) is one necessary component in California’s strategy in meeting its carbon neutrality goals. CCUS serves as an important piece to reduce greenhouse gas emissions where other sequestration methods are not yet feasible for certain sectors like electricity generation, cement production and refineries. At the same time, the impacts of industrial projects disproportionately impact underserved communities, and there is a need for more equitable community engagement practices. The state has had an increase in CCUS projects, and several are or will be in Kern County, which has often been a leader in the oil and …


An Association Test For Ordinal Outcomes In Clustered Data With Informative Cluster Size, Hasika K. Wickrama Senevirathne, Sandipan Dutta Jan 2026

An Association Test For Ordinal Outcomes In Clustered Data With Informative Cluster Size, Hasika K. Wickrama Senevirathne, Sandipan Dutta

Mathematics & Statistics Faculty Publications

In cluster-correlated data, the number of observations in a cluster can be associated with the outcome from that cluster. This phenomenon is known as informative cluster size which can occur in cluster-randomized clinical trial data. Several studies have found that ignoring the issue of informative cluster size can produce biased results in the analysis of clustered data. Most of the existing methods for addressing informative cluster size are suited to continuous outcomes. However, ordinal outcomes and covariates are often encountered in clustered data obtained from large clinical studies. The existing methods for ordinal association testing in clustered data can produce …


Real-World Anti-Amyloid Therapy Beyond Traditional Symptomatic Populations: A Longitudinal Case Series, Jayoung Han, Yuan Fang, Darlingtina Esiaka, Olufunmilola Abraham Jan 2026

Real-World Anti-Amyloid Therapy Beyond Traditional Symptomatic Populations: A Longitudinal Case Series, Jayoung Han, Yuan Fang, Darlingtina Esiaka, Olufunmilola Abraham

Mathematics & Statistics Faculty Publications

Introduction: Anti-amyloid monoclonal antibodies are approved as disease-modifying therapies for early Alzheimer’s disease (AD), but real-world evidence remains limited, particularly among individuals treated during preclinical or minimally symptomatic stages. This study characterized clinical and biomarker trajectories among anti-amyloid therapy recipients across disease stages.

Method: We conducted a longitudinal retrospective case series of three biomarker-positive individuals from the Alzheimer’s Disease Neuroimaging Initiative who received lecanemab or donanemab. Clinical, cognitive, cerebrospinal fluid, plasma biomarker, and amyloid PET data were examined.

Results: In all three cases, most of the observation period preceded anti-amyloid therapy initiation. Clinical trajectories varied by biomarker profile and treatment …


Dextromethorphan And Trace Level Detections Of Dextrorphan In Post-Race Urine Samples – A Case Report And Analysis, Kimberly Brewer, Justin C. Holmes, Clara Fenger, Abelardo Morales-Briceño, Andreas F. Lehner, George A. Maylin, Robert Holland, Levent Dirikolu, Thomas Tobin Jan 2026

Dextromethorphan And Trace Level Detections Of Dextrorphan In Post-Race Urine Samples – A Case Report And Analysis, Kimberly Brewer, Justin C. Holmes, Clara Fenger, Abelardo Morales-Briceño, Andreas F. Lehner, George A. Maylin, Robert Holland, Levent Dirikolu, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Dextrorphan is a Phase I equine metabolite of dextromethorphan, a widely used anti-tussive / cough suppressant medication marketed and available in numerous over-the-counter formulations in the United States. Dextromethorphan is an Association of Racing Commissioners International (ARCI) drug class 4 penalty class B substance and a Horseracing Integrity and Welfare Authority (HIWU) CONTROLLED S7 B substance and is regulated as such in horse racing. In horses, dextromethorphan is metabolized to its Phase I metabolite, dextrorphan, which is next glucuronidated and the resultant dextrorphan-glucuronide conjugate then excreted at remarkably high concentrations in equine urine. Dextrorphan is therefore at times identified in …


Increasing Uptake Of Diabetes Self-Management Education And Support (Dsmes) In Rural Kentucky Primary Care Clinics, Mary E. Lacy, Jessica Elliott, Vance Drakeford, Laura Wright, Brent Mckune, Key C. Douthitt, Aaron J. Kruse-Diehr, James W. Keck Jan 2026

Increasing Uptake Of Diabetes Self-Management Education And Support (Dsmes) In Rural Kentucky Primary Care Clinics, Mary E. Lacy, Jessica Elliott, Vance Drakeford, Laura Wright, Brent Mckune, Key C. Douthitt, Aaron J. Kruse-Diehr, James W. Keck

Epidemiology and Environmental Health Faculty Publications

Background: Diabetes self-management education and support (DSMES) is an evidence-based intervention that improves outcomes for people with diabetes, but uptake is <10%. We conducted a pilot pragmatic trial to increase DSMES in rural primary care clinics that integrated health information technology with a quality improvement (QI) learning collaborative. Methods: Two healthcare systems from rural Kentucky participated in the study. Within each system, 2 clinics received the intervention and 1 clinic served as a control (N = 6 clinics). Each intervention clinic identified a QI team (5-6 individuals) who participated in a 9-month QI learning collaborative followed by 5 months of follow-up. Our primary outcome was DSMES referrals; secondary outcomes were DSMES attendance and percentage with A1c >9%. Results: The 6 study clinics served 1,803 patients with diabetes; n = 1083 (60.1%) from 4 intervention clinics and n = 720 (39.9%) from 2 control clinics. DSMES referrals significantly increased in the intervention clinics compared to the control clinics (31.7% vs 0.1%, P < .001) and continued to increase throughout 5-month follow-up (40.0% vs 0.1%, P < .001). Conclusions: A structured QI intervention can significantly increase DSMES referral rates in primary care clinics. Findings highlight the potential of systems-level approaches to address persistent gaps in diabetes care delivery in rural settings. Clinical Trial Registry: Using Practice Facilitation and Operationalizing Referral Information Technology to Increase DSMES Utilization (Clinicaltrials.gov registration number no. NCT05472142). Clinicaltrials.gov URL (https://clinicaltrials.gov/study/NCT05472142).


The Association Between Human Papillomavirus Type 16 E6 Seroprevalence And Degrees Of Anal Disease Among Men With Hiv, Krystle A.Lang Kuhs, Christopher Otieno, Staci Sudenga, Tim Waterboer, Weiqun Tong, Dorothy Wiley, Jay H. Bream, Steven Wolinsky, Jeremy Martinson, Gypsyamber D’Souza Jan 2026

The Association Between Human Papillomavirus Type 16 E6 Seroprevalence And Degrees Of Anal Disease Among Men With Hiv, Krystle A.Lang Kuhs, Christopher Otieno, Staci Sudenga, Tim Waterboer, Weiqun Tong, Dorothy Wiley, Jay H. Bream, Steven Wolinsky, Jeremy Martinson, Gypsyamber D’Souza

Epidemiology and Environmental Health Faculty Publications

Introduction: Human papillomavirus type 16 (HPV16) E6 antibodies may be an early biomarker of anal cancer. We cross-sectionally evaluated when in the course of anal disease, HPV16 antibodies are induced. Methods: A nested case-control study of 846 men who have sex with men (MSM) was conducted within a prospective study of men with and without HIV. Cases of anal HPV16 (N=262), biopsy-confirmed high-grade squamous intraepithelial lesion (HSIL;N=140), and anal cancer (N=21) were individually matched to controls (N=423) on HIV status, study-participation duration, and age. Serum samples closest to diagnosis underwent HPV serologic testing; prediagnostic serial samples were tested for anal …


A Comprehensive Analysis Of Jurisdiction-Specific Laws Related To Scheduling Or Required Prescription Drug Monitoring Of Gabapentin In The United States, 2016–2024, Katherine Gora Combs, Rachel Vickers-Smith, Collin Stewart, Daniel Wacker, Juan M Hincapie-Castillo Jan 2026

A Comprehensive Analysis Of Jurisdiction-Specific Laws Related To Scheduling Or Required Prescription Drug Monitoring Of Gabapentin In The United States, 2016–2024, Katherine Gora Combs, Rachel Vickers-Smith, Collin Stewart, Daniel Wacker, Juan M Hincapie-Castillo

Epidemiology and Environmental Health Faculty Publications

Gabapentin prescription use has increased across the United States since the late 2000s. Concerns of potential misuse and growing overdose involvement have led to the passage of jurisdiction-specific policies targeting gabapentin prescribing; however, the current legal landscape of these policies is not well documented or understood. We conducted a comprehensive, longitudinal analysis of policies related to scheduling or required prescription drug monitoring of gabapentin across 51 jurisdictions in the United States from January 2016 through December 2024. Across the study period, 25 jurisdictions (49 %) enacted policies related to gabapentin scheduling or required prescription reporting. Eight (16 %) jurisdictions classified …


Optimizing Control Definitions In Opioid Use Disorder Genetic Research Using Electronic Health Records, Maria Niarchou, Ellen L Tsai, Mariela V Jennings, Annika Faucon, Hyunjoon Lee, Kritika Singh, Justin D Tubbs, Panos Roussos, Tian Ge, Richard C Crist, Rachel Vickers-Smith, Howard Edenberg, Amy Moore, Bradley T Webb, Eric O Johnson, Rachel L Kember, Jordan W Smoller, Lea K Davis, Brandon J Coombes, Georgios Voloudakis, David Burstein, Travis T Mallard, Vanessa Troiani, Sandra Sanchez-Roige Jan 2026

Optimizing Control Definitions In Opioid Use Disorder Genetic Research Using Electronic Health Records, Maria Niarchou, Ellen L Tsai, Mariela V Jennings, Annika Faucon, Hyunjoon Lee, Kritika Singh, Justin D Tubbs, Panos Roussos, Tian Ge, Richard C Crist, Rachel Vickers-Smith, Howard Edenberg, Amy Moore, Bradley T Webb, Eric O Johnson, Rachel L Kember, Jordan W Smoller, Lea K Davis, Brandon J Coombes, Georgios Voloudakis, David Burstein, Travis T Mallard, Vanessa Troiani, Sandra Sanchez-Roige

Epidemiology and Environmental Health Faculty Publications

Amidst the opioid crisis, understanding the genetic basis of opioid use disorder (OUD) is crucial for identifying biological mechanisms and intervention points. However, genome-wide association studies (GWASs) have been hampered by inadequate sample sizes and often the use of control populations not assessed for prior opioid exposure. Because opioid exposure is a prerequisite for the development of OUD, consideration of exposure history in controls is important. Electronic health record data (EHR) paired with genomic information allow a broader sampling of patients with OUD and exposed controls. We leveraged data across two healthcare systems to evaluate the impact of using controls …


Shaping The Future Of Human Biomonitoring (Hbm), Maryam Zare Jeddi, Nancy B. Hopf, Karen S. Galea, Kate Jones, Henriqueta Louro, Maria João Silva, Adrian Covaci, Tiina Santonen, Paul T.J. Scheepers, Susana Viegas, Lesliam Quirós-Alcalá, Asif Qureshi, M. Elizabeth Marder, Natalie Von Goetz, Konstantinos M. Kasiotis, Kyriaki Machera, Ovnair Sepai, Radu Corneliu Duca, Manosij Ghosh, An Van Nieuwenhuyse, Ming Kei Chung, Jihyon Kil, Shoji F. Nakayama, Aziza Menouni, Kaoutar Chbihi, Ana Maria Vekic, Gustavo Souza, Maisarah Nasution Waras Jan 2026

Shaping The Future Of Human Biomonitoring (Hbm), Maryam Zare Jeddi, Nancy B. Hopf, Karen S. Galea, Kate Jones, Henriqueta Louro, Maria João Silva, Adrian Covaci, Tiina Santonen, Paul T.J. Scheepers, Susana Viegas, Lesliam Quirós-Alcalá, Asif Qureshi, M. Elizabeth Marder, Natalie Von Goetz, Konstantinos M. Kasiotis, Kyriaki Machera, Ovnair Sepai, Radu Corneliu Duca, Manosij Ghosh, An Van Nieuwenhuyse, Ming Kei Chung, Jihyon Kil, Shoji F. Nakayama, Aziza Menouni, Kaoutar Chbihi, Ana Maria Vekic, Gustavo Souza, Maisarah Nasution Waras

Epidemiology and Environmental Health Faculty Publications

Human biomonitoring (HBM) continues to play an indispensable role within exposure science, offering insights into aggregate chemical exposures across populations and life stages. Since 2018, the European chapter of the International Society of Exposure Science Human Biomonitoring Working Group (ISES Europe HBM WG) has aimed to facilitate generation of more and high-quality HBM data. The working group aims to strengthen integration of HBM data into regulatory frameworks through improved study design, harmonized methodologies, and enhanced reporting practices. Key achievements in the past seven years include the harmonization of HBM metadata through development of minimum information requirements for HBM (MIR-HBM), development …


Association Between Educational Attainment And Discharge Disposition Following Incident Stroke Hospitalization, Ning Li, Erin L. Abner, Silvia Koton, Lena Mathews, Kunihiro Matsushita, Anna Kucharska-Newton Jan 2026

Association Between Educational Attainment And Discharge Disposition Following Incident Stroke Hospitalization, Ning Li, Erin L. Abner, Silvia Koton, Lena Mathews, Kunihiro Matsushita, Anna Kucharska-Newton

Epidemiology and Environmental Health Faculty Publications

Background – The relationship between educational attainment and discharge disposition after stroke hospitalization remains unclear. This study examined whether educational attainment is associated with discharge disposition after incident stroke and whether stroke severity modifies this association. Methods – The study included Atherosclerosis Risk in Communities (ARIC) participants with an incident stroke hospitalization from 1991 to 2020 who were enrolled in fee-for-service (FFS) Medicare at discharge. Discharge disposition was obtained from hospitalization claims. Educational attainment was categorized as “less than high school” vs. “high school or more.” Multivariable logistic regression models were used to estimate associations between educational attainment and discharge …


Building The Ryan White Hiv/Aids Program Bench In Kentucky, Lauren Bifulco, Kathleen Harding, Jana Collins, Anna Rogers, Lenon Farkash, Marwan Haddad, Alice Thornton Jan 2026

Building The Ryan White Hiv/Aids Program Bench In Kentucky, Lauren Bifulco, Kathleen Harding, Jana Collins, Anna Rogers, Lenon Farkash, Marwan Haddad, Alice Thornton

Epidemiology and Environmental Health Faculty Publications

The Ryan White HIV/AIDS program (RWHAP) is governed by legislative and programmatic guidelines that ensure comprehensive services are provided to persons with HIV (PWH) across the United States. Comprehensive training and skill building opportunities for programmatic staff are rare. RWHAP funding recipient organizations may struggle to acquire and retain essential program-specific knowledge, with downstream impact on patient care and treatment. We designed a comprehensive 11-session videoconference learning series to improve program staff’s confidence and competence with RWHAP fundamentals. Quantitative pre-vs-post session data were analyzed using Wilcoxon Signed-Rank tests, and qualitative data using thematic analysis. We enrolled 136 staff from 23 …


Decreased Gabapentin Prescription Fills Among Medicaid Enrollees Following State-Level Schedule V Controlled Substance Classification In Kentucky And West Virginia, Katherine Gora Combs, Stephen W. Marshall, Rachel Vickers-Smith, Alan Kinlaw, Nabarun Dasgupta, Juan M. Hincapie-Castillo Jan 2026

Decreased Gabapentin Prescription Fills Among Medicaid Enrollees Following State-Level Schedule V Controlled Substance Classification In Kentucky And West Virginia, Katherine Gora Combs, Stephen W. Marshall, Rachel Vickers-Smith, Alan Kinlaw, Nabarun Dasgupta, Juan M. Hincapie-Castillo

Epidemiology and Environmental Health Faculty Publications

Background: Driven by concerns of gabapentin misuse and other harms, Kentucky (KY) and West Virginia (WV) became the first states to classify gabapentin as a schedule V controlled substance in July 2017 and June 2018, respectively. This study examined the association of these policies with gabapentin utilization among Medicaid beneficiaries. Methods: Using a controlled interrupted time series design, we modeled a segmented generalized least squares regression and calculated the immediate and trend changes of gabapentin prescriptions among Medicaid enrollees in 2 states (KY, WV), separately. North Carolina (NC) was used as a control to account for secular changes; there was …


Decreased Exercise-Induced Pulmonary Capillary Recruitment In Pulmonary Arterial Hypertension, David Langleben, Stylianos E. Orfanos, Benjamin D. Fox, Michele Giovinazzo, Magali Kaddis, John D. Catravas Jan 2026

Decreased Exercise-Induced Pulmonary Capillary Recruitment In Pulmonary Arterial Hypertension, David Langleben, Stylianos E. Orfanos, Benjamin D. Fox, Michele Giovinazzo, Magali Kaddis, John D. Catravas

Bioelectrics Publications

The human lung normally accommodates exercise-induced cardiac output increases mainly via recruitment of non-concomitantly perfused pulmonary capillaries. Recruitment is detectable by measuring the first-pass transpulmonary metabolism of ³H-benzoyl-Phe-Ala-Pro, providing an estimate of functional capillary surface area (FCSA). Pulmonary arterial hypertension (PAH) results from luminal narrowing of small precapillary arterioles, reducing downstream perfused FCSA. We hypothesized that exercising PAH patients would not be able to recruit FCSA normally. We studied two patients with severe PAH. Despite exercising to maximal dyspnea, neither could recruit FCSA. These limited data are the first direct measurements of FCSA in exercising PAH patients.


Metabolic Reprogramming Following Mitochondrial Transfer Between Idh2-Mutant Chondrosarcoma Cells And A Normal B-Cell Line, Caleb Wyckoff, Christopher Osgood, Ellen Jing, Michael Stacey Jan 2026

Metabolic Reprogramming Following Mitochondrial Transfer Between Idh2-Mutant Chondrosarcoma Cells And A Normal B-Cell Line, Caleb Wyckoff, Christopher Osgood, Ellen Jing, Michael Stacey

Bioelectrics Publications

Background/Objectives: Chondrosarcoma, glioblastoma, acute myeloid leukemia, chronic lymphocytic leukemia, and cholangiocarcinoma cancers all contain mutations in the gene isocitrate dehydrogenase 2 (IDH2). The mutant IDH2 enzyme metabolizes alpha-ketoglutarate (αKG) into the potent oncometabolite D-2-hydroxyglutarate (D2HG) in the mitochondria of these cancers, leading to altered cellular metabolism. Emerging evidence suggests that mitochondrial transfer between cancer and recipient cells represents an important form of intercellular communication that may influence cellular metabolism. The presence of intercellular TNTs between IDH2-mutant chondrosarcoma cells motivated an investigation into mitochondria-associated physiological changes occurring during an intercellular exchange with immune cells. A mitochondrial transfer is a two-way …


Establishment And Histopathological Characterization Of A Kyse-30 Subcutaneous Xenograft Model Of Esophageal Squamous Cell Carcinoma, Pavel A. Solopov, Alayna Enos, Mantas Silkunas, Giedre Silkuniene, Eleni Zivla, Andrei G. Pakhomov, Olga N. Pakhomova Jan 2026

Establishment And Histopathological Characterization Of A Kyse-30 Subcutaneous Xenograft Model Of Esophageal Squamous Cell Carcinoma, Pavel A. Solopov, Alayna Enos, Mantas Silkunas, Giedre Silkuniene, Eleni Zivla, Andrei G. Pakhomov, Olga N. Pakhomova

Bioelectrics Publications

Background/Objectives: Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with poor prognosis and limited treatment options, highlighting the need for reliable preclinical models for translational research. Although xenograft models are widely used in cancer biology, systematic characterization of subcutaneous ESCC models under defined implantation conditions remains limited. The objective of this study was to systematically compare implantation conditions and define histopathological and growth-related parameters that enable reproducible tumor establishment while maintaining a practical experimental window for therapeutic studies. Methods: We established and characterized a subcutaneous ESCC xenograft model using human ESCC cell line KYSE-30 implanted into immunodeficient J:NU mice. …


Combination Therapy With Hsp90 Inhibitors And Nanopulse Stimulation Synergistically Impedes Hepatocellular Carcinoma And Breast Cancer Growth In Mice, Christiana Dimitropoulou, Gagan Thangjam, Brittany P. Lassiter, Teresa Hooker, Ruben M. L. Colunga Biancatelli, John D. Catravas, Stephen J. Beebe Jan 2026

Combination Therapy With Hsp90 Inhibitors And Nanopulse Stimulation Synergistically Impedes Hepatocellular Carcinoma And Breast Cancer Growth In Mice, Christiana Dimitropoulou, Gagan Thangjam, Brittany P. Lassiter, Teresa Hooker, Ruben M. L. Colunga Biancatelli, John D. Catravas, Stephen J. Beebe

Bioelectrics Publications

Nanopulse Stimulation (NPS) represents a promising and innovative therapeutic approach to cancer. Heat shock protein 90 Inhibitors (HI), on the other hand, are currently under investigation in multi-drug chemotherapy trials for various types of malignancies. Here we present results of a combination therapy employing two HSP90 inhibitors (AUY-922 or 17-AAG) and NPS to ablate cancer growth. We firstly tested the inhibitors alone or in combination with NPS in vitro in N1S1 cells, and then into two models of orthotopic Hepatocellular Carcinoma (HCC) and 4T1-Luc breast cancer. NPS + HI reduced tumor growth more than the sum of HI and NPS …


Cxcr6+ Natural Killer Cell Immunotherapy Preserves Cd4+ T Helper Cells In Humanized Mice, Naushad Khan, Kayla Frank, Silke Paust Jan 2026

Cxcr6+ Natural Killer Cell Immunotherapy Preserves Cd4+ T Helper Cells In Humanized Mice, Naushad Khan, Kayla Frank, Silke Paust

Faculty Research 2026

Human immunodeficiency virus (HIV) persists despite antiretroviral therapy because long-lived viral reservoirs are not eliminated, and ongoing or rebound infection contributes to progressive loss of CD4+ T helper cells. Natural killer (NK) cells can acquire adaptive, antigen-experienced functions, including recall responses to HIV envelope protein, suggesting that defined NK-cell subsets may be therapeutically useful against HIV. Because HIV-responsive adaptive NK-cell activity is enriched among CXC chemokine receptor 6-positive (CXCR6+) NK cells, we tested whether CXCR6+ NK cells provide enhanced antiviral activity and CD4+ T-cell protection compared with CXCR6− NK cells. In co-cultures with HIV-infected …


Legislating Infrastructure: A State-Level Model To Accelerate Endometriosis Research And Women's Health Equity., E T Courtois, L Roy, Jasmina Uvalic, K Mullaj, D Lockshire, D E Luciano Jan 2026

Legislating Infrastructure: A State-Level Model To Accelerate Endometriosis Research And Women's Health Equity., E T Courtois, L Roy, Jasmina Uvalic, K Mullaj, D Lockshire, D E Luciano

Faculty Research 2026

Impact statement: A legislatively mandated, statewide endometriosis biorepository integrated within a multidisciplinary endometriosis focused program demonstrates how policy-driven infrastructure can integrate education, clinical care, harmonized biobanking, and translational research to address persistent gaps in women's health in the long term. The Connecticut Endometriosis Working Group (EWG), a group of legislators, researchers, patients, health care providers, and advocates, was established in 2021. The EWG met monthly to discuss strategies to address endometriosis and propose endometriosis specific legislation which has been a turning point. Public Acts 22-33 and 23-67 directed the establishment, governance, and annual reporting of a coordinated endometriosis data and …


Identifying Transcriptomic Signatures That Mediate The Causal Effect Of Genotype On Alzheimer's Disease., Simran Kaur, Anna L. Tyler, Giovanna L Durante, Gregory Cary, Gregory W. Carter, J Matthew Mahoney Jan 2026

Identifying Transcriptomic Signatures That Mediate The Causal Effect Of Genotype On Alzheimer's Disease., Simran Kaur, Anna L. Tyler, Giovanna L Durante, Gregory Cary, Gregory W. Carter, J Matthew Mahoney

Faculty Research 2026

The combined effects of thousands of genetic polymorphisms account for Alzheimer's disease (AD) genetic risk. Most AD polymorphisms affect gene expression. Thus, the transcriptome, the set of all gene expression levels for every gene in the genome, is a major mediator between the genotype to phenotype. This study uses genotypes, transcriptomes, and clinical phenotypes to identify the transcriptomic signature that mediates the causal effect of genotype on AD. By utilizing a causal inference method known as high dimensional mediation analysis (HDMA) on the Religious Orders Study/Memory and Aging Project (ROSMAP) longitudinal cohort, the genotype, transcriptome, and phenotype data were reduced …


Editorial: Interdisciplinary Innovations In Car T-Cell Therapy For Autoimmune And Cancer Treatment., Apostolos Zaravinos, Derya Unutmaz, Marko Radic Jan 2026

Editorial: Interdisciplinary Innovations In Car T-Cell Therapy For Autoimmune And Cancer Treatment., Apostolos Zaravinos, Derya Unutmaz, Marko Radic

Faculty Research 2026

No abstract provided.


Genetic Counselors' Perspectives And Experiences With Workplace Genetic Testing: Results Of A National Survey., Alexandra Truhlar, Elizabeth Charnysh, Subhamoy Pal, Jonathan M Reader, Katherine Hendy, W Gregory Feero, Kerry Ryan, Alyx Vogle, Sarah Mccain, Rebecca A Ferber, Jill Furnival, Charles Lee, J Scott Roberts, Wendy R Uhlmann, Kunal Sanghavi, Insight @ Work Consortium Jan 2026

Genetic Counselors' Perspectives And Experiences With Workplace Genetic Testing: Results Of A National Survey., Alexandra Truhlar, Elizabeth Charnysh, Subhamoy Pal, Jonathan M Reader, Katherine Hendy, W Gregory Feero, Kerry Ryan, Alyx Vogle, Sarah Mccain, Rebecca A Ferber, Jill Furnival, Charles Lee, J Scott Roberts, Wendy R Uhlmann, Kunal Sanghavi, Insight @ Work Consortium

Faculty Research 2026

Purpose

Workplace genetic testing (wGT) is a wellness benefit offered to employees, providing a new access point for genetic testing. Although genetic counseling is not typically required in wGT, genetic counselors (GCs) play a key role in integrating genetic testing into health care and may interact with wGT in industry, laboratory, or clinical settings.

Methods

To ascertain US GCs’ perspectives and experiences with wGT, we administered a web-based survey, targeting GCs most likely to have professional experience with wGT. Descriptive statistics were used to characterize responses.

Results

Of n = 331 participants (mean age = 36, >80% White female), 27.0% …


Editorial: Interdisciplinary Innovations In Car T-Cell Therapy For Autoimmune And Cancer Treatment., Apostolos Zaravinos, Derya Unutmaz, Marko Radic Jan 2026

Editorial: Interdisciplinary Innovations In Car T-Cell Therapy For Autoimmune And Cancer Treatment., Apostolos Zaravinos, Derya Unutmaz, Marko Radic

Faculty Research 2026

No abstract provided.


Wilson, Issue 02, 2025-26, University Of Northern Iowa. Wilson College Of Business. Jan 2026

Wilson, Issue 02, 2025-26, University Of Northern Iowa. Wilson College Of Business.

Wilson

Contents:

From the Dean --- 3
Auditing Students Learn Emerging Technologies and Real-World Analysis --- 4
How Real Estate Students are Learning Industry Software in the Classroom --- 8
Marketing in the Age of Data --- 14
Building Communities, Shaping Futures --- 18
Data Drives Business Success for UNI Student Entrepreneurs --- 22
Data to Assist in Iowa Stomr Response --- 23
Ethical Considerations of Data Breaches --- 24
How Ethics and Data Management Intersect In Today's Business Climate --- 26
Students Dominate Advertising Competition --- 28
AACSB Supplemental Accounting Accreditation --- 30
A New Era for Business: UNI's Wilson …