Digital Commons Network^™

Search Strategies For “Quality Of Life Measures In The Study Of Neurogenic Dysfunction Among Children And Adolescents With Spina Bifida”, Erin Witt, Heidi Castillo, Gene O. Huang, Kesha Balakrishnan, Jonathan Castillo, Danielle Westmark

Search Strategies: Leon S. McGoogan Health Sciences Library

No abstract provided.

Forage News [2026-04], University Of Kentucky

Forage News

No abstract provided.

Forage News [2026-02], University Of Kentucky

Forage News

No abstract provided.

Forage News [2026-01], University Of Kentucky

Forage News

No abstract provided.

Inhibition Of Fatty Acid Synthase Enhances Therapeutic Efficacy And Delays Acquired Resistance To Braf-Targeted Therapy In Colorectal Cancer, Mariah E. Geisen, Elisane W. Tessmann, Courtney O. Kelson, Daheng He, Chi Wang, Abu Saleh Mosa Faisal, Ellen J. Beswick, Yasmine Baca, Stephanie Rock, Jill M. Kolesar, Yekaterina Y. Zaytseva

Toxicology and Cancer Biology Faculty Publications

The presence of BRAF ^V600E mutations is associated with poor prognosis in colorectal cancer (CRC). Although the FDA-approved combination of encorafenib and cetuximab provides clinical benefit in this population, only 22% of patients respond and most eventually develop resistance. This study investigated the mechanisms of resistance to PLX8394, a second-generation BRAF inhibitor. Using primary and established BRAF ^V600E CRC cells, we show that the development of resistance to PLX8394 results in cross-resistance of cells to encorafenib. Moreover, the acquired resistance is associated with increased proliferation, invasion, and upregulation of lipid metabolism, including increased expression of fatty acid synthase (FASN), a …

Long Acting Beta2-Adrenergic Receptor Agonists Reverse Diabetic Nephropathy And Liver Steatosis In Murine Models Of Diabetes And Are Associated With Protection In Retrospective Human Studies, Brennan Winkler

MUSC Theses and Dissertations

Diabetes Mellitus (DM) affects 13.9% of men and 14.3% of women worldwide, a total of approximately 828 million people. Patients with diabetes are at risk of several complications including diabetic nephropathy (DN) and metabolic-associated steatohepatitis (MASH). These diseases eventually lead to end stage kidney disease (ESKD) and liver failure requiring dialysis and organ transplantation. In addition, diabetes exacerbates disease severity of autosomal dominant polycystic kidney disease (ADPKD), the most common potentially lethal genetic disease to affect humans with a prevalence of 1 in 500-1000. Therefore, a therapeutic approach that can attenuate organ damage and restore function in patients with DM, …

The Impact Of The Different Vdac Isoforms On Hbv Replication And Hbx Localization, Cody Mcumber

MUSC Theses and Dissertations

Chronic hepatitis B virus (HBV) infection is the leading cause of hepatocellular carcinoma worldwide. Despite the availability of a preventative vaccine, there are approximately 254 million people living with a chronic HBV infection. There are 9 known HBV genotypes, each with their own clinical impacts and manifestation in infected patients. HBx is the only regulatory protein encoded by the HBV genome and is required for efficient viral replication. HBx has many effects in infected hepatocytes besides known effects on HBV replication, such as localization to the mitochondria. HBx is also known to have impacts on mitochondrial membrane potential, mitochondrial permeability …

A Scenario Analysis Of The Impact Of H.R.1 2025 Medicaid Coverage Loss And Payment Reductions On U.S. Hospital Operating Margins, Tangee Pruitt

MUSC Theses and Dissertations

The “Big Beautiful Bill” is expected to affect the financial health of U.S. hospitals. We performed a scenario analysis using five case studies combined with national data on payer mix information to illustrate potential impact in 2027. The scenarios explored the following question: What is the expected healthcare access and economic impact of H.R.1 under three sets of assumptions: 1) loss of Medicaid coverage for 10% or more of an institution’s current patients who will then become uninsured; 2) decrease in Medicaid payments by 10% or more; 3) loss of Medicaid coverage and decrease in Medicaid payments simultaneously. We defined …

Twenty-First Century Data Systems: Evolving Cancer Registries To A Learning Health System, Peter P. Yu, W. Scott Campbell, Eric B. Durbin, Lawrence N. Shulman, Jeremy L. Warner

Markey Cancer Center Faculty Publications

Introduction: Oncology is a data-rich environment reflecting the increasing incidence of cancer in the US aging population, transformation of cancer into a chronic disease due to advances in treatment, and the emergence of new data categories such as genomics. Concomitantly, healthcare systems are challenged to meet regulatory and voluntary reporting of cancer data to support government, quality certification, research and strategic partnership needs.

Materials and Methods: The National Academies of Science, Engineering, and Medicine organized a workshop entitled “Enabling 21st-century applications for cancer surveillance through enhanced registries and beyond” with representation from NCI Comprehensive Cancer Centers, oncology and medical informatics …

Psychosocial Strengths Associated With Higher Functioning After Interpersonal Adversity In The United Kingdom And Ireland, Matthew Brooks, Victoria Banyard, Xiafei Wang, Sherry Hamby

Social Work Faculty Publications

Objective: Over the past two decades, positive psychology research has identified correlates of resilience. Although a range of strengths have been explored, there is a need to identify specific strengths that best support individuals to thrive after interpersonal trauma and adversity. This study assessed the contribution of 24 strengths from the Values in Action (VIA) positive psychology survey, alongside five other measures of strengths identified from resilience research, to identify those that show most promise.

Method: In total, 1,440 adults from the United Kingdom and Ireland completed the online VIA survey, and questions on five psychosocial strengths (ecoconnections, …

Compassionate Care In The Library Workplace, Shannon D. Jones

MUSC Faculty Bookshelf

This chapter explores the role of compassionate care as a critical leadership practice in the library workplace, with a particular focus on academic health sciences libraries. Drawing on the author’s lived experience as a Black woman library leader and on over two decades in the profession, the chapter situates compassionate care at the intersection of compassionate and inclusive leadership and organizational well-being. In the context of ongoing collective trauma, including the COVID-19 pandemic, racial violence, political polarization, and sustained attacks on libraries, the chapter argues that compassion must move beyond empathy to intentional, actionable leadership. It examines how social identities, …

Teaching Economics Behind The Global Covid-19 Pandemic, Chengping Zhang

Faculty Publications - College of Business

The global COVID-19 pandemic has upended our daily lives in unprecedented ways. Several extraordinary economic events have occurred and have brought some intriguing and important questions to everyone’s mind, creating an immersive teaching and learning environment. This paper shows how economic instructors may take advantage of this opportunity to educate their students with some key economic principles/theories using these COVID-19 related events. Integrating current events into economics instruction can stimulate students’ interests and inspire them to think about the economics behind each event. The relevance and relatedness of these events can also boost students’ motivation and engagement. This paper will …

Policy Recommendations And Ways Forward, Rachel Locke, Jocelyn Getgen Kestenbaum

Book Chapters

This chapter discusses how the transformative ideas presented by the contributors can be applied in concrete and meaningful ways to policy, practice, and research. The chapter begins with a discussion of principles that were both crucial to the articulation of the recommendations and are similarly crucial to any proposal to address identity-based mass violence. The human-centered values of this volume demand a focus not only on outcomes but also on process, as these principles attest. The chapter then focuses on practical areas of action, from capacity building to funding to shifting narratives, and more. This chapter shifts from prescriptive policy …

Clopidogrel Versus Aspirin Monotherapy Following Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: An Updated Meta- Analysis Of 162,829 Patients, Mohammed A. Elbahloul, Ahmed Mansour, Amr Galal, Walaa M. Moawad, Manar Khaled, Ahmed Wahdan Kasem, Eman E. Labeeb, Islam Y. Elgendy

Gill Heart & Vascular Institute Faculty Publications

Background: Dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) remains a cornerstone for preventing ischemic events; however, the optimal long-term single antiplatelet therapy after completion of DAPT remains unclear. We aimed to compare clopidogrel and aspirin monotherapy after completion of the standard duration of DAPT.

Methods: A systematic search was conducted on PubMed, Scopus, Cochrane Library, and Web of Science from inception to April 2025. We included randomized clinical trials and observational studies that compared aspirin versus clopidogrel monotherapy after completion of standard-duration DAPT. The primary and co-primary outcomes were major adverse cardiovascular events (MACE) and major bleeding, respectively. …

Expanding Access To Urban Nature: Floating Gardens As Equitable And Inclusive Blue-Green Infrastructure In The Chicago River, Michael Hendricks, Alec Foster, Noha Shawki, Mariela Fernandez, Sage Rossman, Sierra Mack-Erb, Eric Peterson

Faculty Publications – Politics and Government

This study examines the social dimensions of Urban Rivers’ Free Kayak Days at the Bubbly Creek Floating Gardens in Chicago, Illinois. Floating gardens are a form of blue-green infrastructure that provide ecological benefits, including nutrient removal, habitat creation, and shoreline stabilization, while also offering recreational and educational opportunities. Guided by environmental justice scholarship, our interdisciplinary team conducted participant observation to evaluate whether Urban Rivers’ Freek Kayak Days effectively engaged residents from surrounding marginalized communities. Four themes emerged: (1) access and inclusion, highlighting reduced financial barriers but ongoing challenges related to safety perceptions, cultural relevance, and physical accessibility; (2) community engagement …

Ai Is Coming For Your Mind: A Case For Consumer Protection, Blithe Ellis

Gateway Reader- Individual Papers

• The Problem: Immersive and anthropomorphic artificial intelligence (AI) chatbots can trigger, amplify, or reshape psychotic experiences—colloquially termed "AI psychosis"—by mirroring user language, validating delusional beliefs, and prioritizing user engagement over safety.

• The Method: The author analyzes peer-reviewed psychiatric literature, media reports from 2025, and user discussions on the r/ChatGPT Reddit forum to advocate for consumer protection regulations.

• Quantitative Finding: The analysis incorporates data from the year 2026, references cases involving a 26-year-old woman, and evaluates a specific Reddit thread featuring hundreds of user stories regarding AI-fueled delusions.

• Qualitative Finding: Shared themes in AI-associated distress include messianic missions, delusions of chatbot …

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Linking Curiosity To Career: A Master Adaptive Approach To Resident Elective In Family Medicine Training, Shayna Blikshteyn, Drew Keister Md, Karla J Felix Phd, Susan S. Mathieu Md, Lynn M. Wilson Do

Department of Family Medicine

No abstract provided.

The Effects Of Unilateral Resistance Training In Resistance Trained Women, Jeremiah Amande.' Miller

Master of Science in Kinesiology

Background: Muscle hypertrophy is defined as the increase in size, thickness, and girth of human skeletal muscle and is mostly induced by resistance training (RT). A large body of assessment literature suggests that there are many training methods that can induce muscle hypertrophy, underscoring the importance of training specificity. Training to muscular failure vs non-failure remains a heavily debated topic in the literature and fitness industry, showing mixed results in the published literature. Additionally, there is a lack of literature examining muscle hypertrophy in resistance-trained women using a unilateral approach. Purpose: This paper responds to these challenges by examining failure …

Coupling Liquid Chromatography To Orbitrap Isotope Ratio Mass Spectrometry: Overcoming Isotope Effects Of Chromatography And Amount-Dependency By Peak Homogenization, Aoife Canavan, Leonhard Prechtl, Habib Al-Ghoul, Nils Kuhlbusch, Andrea M. Erhardt, Martin Elsner

Earth and Environmental Sciences Faculty Publications

Electrospray ionization Orbitrap mass spectrometry (ESI-Orbitrap-MS) has recently proven to be a powerful tool for compound- and position-specific stable isotope analysis, targeting isotopologues of multiple elements (H, C, N, O, S) in polar analytes. However, studies have so far mainly focused on pure analyte solutions via direct infusion. Here, we present the online coupling of liquid chromatography (LC) to ESI-Orbitrap-MS for stable isotope analysis of sulfamethoxazole (SMX), a synthetic antimicrobial, used as a model compound. Our study explored the fidelity of isotope values with two strategies for capturing and broadening chromatographic peaks after LC. When capturing the target analyte in …

Beyond Algorithm Aversion: How Explanation Quality Enables Fairness And Trust In Ai-Based Performance Evaluations, Darren Mcgraw

Doctor of Business Administration (DBA)

Performance evaluation systems increasingly incorporate artificial intelligence, yet employee acceptance remains limited. This experimental study examined how explanation quality and evaluator type influenced fairness perceptions and trust in AI-based performance evaluations among 275 U.S. working adults. Using a 2 × 2 vignette design, results demonstrated that explanation quality produced large effects on perceived fairness (d = 1.79) and trust, while evaluator type—human versus AI—had negligible independent effects (d = −0.08) when explanations were high quality. Fairness mediated the explanation-trust relationship (indirect effect = 1.95, 95% CI [1.65, 2.26]), with inconsistent mediation indicated by a negative direct effect (b = −0.81, …

2026 Commencement Program, Seattle University

Commencement Programs

No abstract provided.

Colchicine Among Patients With Acute Coronary Syndrome: A Meta‑Analysis Of Randomized Trials, Mohamed Hamed, Sheref A. Mohamed, Mohamed Abdelazeem, Eric Lieberman, Abdelrahman Ali, Dharam J. Kumbhani, Anthony Bavry, Hani Jneid, Islam Y. Elgendy, Ayman Elbadawi

Gill Heart & Vascular Institute Faculty Publications

Introduction: Prior trials evaluating the benefit of colchicine in patients with acute coronary syndrome (ACS) have yielded mixed results. Hence, we conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the role of colchicine after ACS.

Methods: We performed an electronic search of MEDLINE, Embase, and Cochrane databases through November 2024 for studies comparing colchicine with placebo after ACS. Our study’s primary outcome was major adverse cardiac events (MACE).

Results: Our final analysis included five RCTs with 12,979 patients with a mean follow-up of 26.6 months. The weighted mean age was 59.8 years. Colchicine was associated with a modest …

The Brave New World Of Administrative Law, Amy J. Wildermuth

Articles

Administrative law is in substantial flux. Over the last fifteen years, beginning with its decision in Free Enterprise Fund v. Public Company Accounting Oversight Board, the Supreme Court has transformed administrative law in profound ways. In the decade and a half since that case, we have witnessed core precedents fall or be substantially narrowed, with seemingly more on the horizon. Many have characterized the Court’s project as aggrandizing power to the President, as seeking to rein in runaway agencies, or even as undoing the administrative state.

The reality is more complex. To grasp where the Court’s project might take …

Effect Of Feeding Whole Soybeans, Roasted Soybeans, Or Distillers Grains In Silage-Based Growing Beef Diets, Melissa K. Bausch, Rebecca Mcdermott, Jim C. Macdonald, Pablo L. Loza, Galen E. Erickson

Nebraska Beef Cattle Reports

Summary with Implications

An individual feeding experiment was conducted to evaluate the effect of feeding raw whole soybeans (WSB), roasted whole (RSB) soybeans or distillers grains (MDGS) at three inclusions (7%, 14%, or 21% of diet dry matter) on growing performance, compared to a common control diet (0%) with urea. The greater inclusions of roasted soybeans or distillers grains increased gain and efficiency in growing cattle. Cattle fed the 21% inclusion of roasted soybeans were the most efficient, likely due to the protected protein increasing rumen undegradable protein content, and the additional energy from the higher levels of fat and …

Effect Of An Accelerated Adaptation Protocol On Performance And Health Of Feedlot Steers Drenched With Lactipro, Rebecca L. Mcdermott, Samuel E. Loy, Isaque F. Vicci, Mark Corrigan, Braden C. Troyer, Galen E. Erickson, Jim C. Macdonald

Nebraska Beef Cattle Reports

Summary with Implications

A finishing study evaluated the effects of an accelerated adaptation protocol in conjunction with Lactipro on performance and health of steers. Five adaptation programs were evaluated with steers adapted to a finishing diet in 21, 14, 7, or 0 days. An additional accelerated adaptation program provided intensive feed delivery with 0-d adaptation. Cattle assigned to the 21-d and 0-d adaptations gained faster and consequently had greater HCW compared to the 7-d and 14-d adaptation, resulting in a quadratic response for ADG and HCW. The 0-d adaptation with intensive feed delivery had similar ADG and HCW compared to …

Effects Of Feeding Raw Soybeans Or Roasted Soybeans To Feedlot Steers, Melissa K. Bausch, Jim C. Macdonald, Pablo L. Loza, Galen E. Erickson

Nebraska Beef Cattle Reports

Summary with Implications

A feedlot study compared feeding raw or roasted soybeans, soybean meal, or distillers grains to a dry-rolled corn with urea control on finishing cattle performance and carcass traits. Cattle fed roasted soybeans had improved marbling and gained more weight over the feeding period than cattle fed whole soybeans. Feed conversion was improved in the steers fed the roasted and whole soybean containing diets over steers that consumed the distillers grains diet. Cattle fed soybean meal and distillers grains had similar performance and carcass characteristics in this experiment. Cattle fed soybeans, soybean meal, or distillers had better gains …

Effect Of Using Either Synovex Primer Or Synovex Choice Compared To Not Implanting On The Performance Of Growing Steers, Sawyer D. Starrett, Rebecca L. Mcdermott, Sofia Suarez Lorences, Pedro Henrique Jota Fernandes, Dirk Burken, Jessica L. Sperber, Galen E. Erickson, Jim C. Macdonald

Nebraska Beef Cattle Reports

Summary with Implications

A 120-day winter-growing study utilized 576 head of steers to evaluate three dry lot implant strategies on the growth of steers. The three implanting strategies included a non-implanted control, Synovex® Primer™, or Synovex Choice®. While on harvested corn residue fields, steers were supplemented with 4 lb Sweet Bran and 0.375 lb of a vitamin and mineral package. The targeted gain for the non-implanted control was 1.25 lb/d. Both Synovex Primer and Synovex Choice increased ADG over the non-implanted control cattle by 7.5% and 12.7%, respectively. Additionally, Synovex Choice had a 4.8% increase in ADG over Synovex Primer. …

Evaluation Of Ferappease Administered At Arrival And Time Of Reimplant On Feedlot Performance And Carcass Characteristics Of Yearling Beef Steers, Carsten L. Loseke, Galen E. Erickson, Jessica L. Sperber

Nebraska Beef Cattle Reports

Summary with Implications

Cattle experience stress in the feedlot during handling events such as initial processing and reimplant that can negatively impact morbidity and mortality, feedlot performance, and carcass outcomes. Application of a maternal Bovine Appeasing Substance (mBAS) marketed as FerAppease (FERA Diagnostics and Biologicals) has been hypothesized to mitigate stress in cattle. A commercial feedlot study compared the effectiveness of FerAppease applied in 10mL doses to yearling native beef steers at initial processing and reimplant to a placebo product on cattle performance, morbidity and mortality parameters, and carcass traits. Steers administered FerAppease tended to have improved feed conversion on …

Effect Of Feed Access Time On Feedlot Cattle Performance, Carcass Characteristics, Feeding Behavior And Ruminal Ph, Carsten L. Loseke, Rebecca L. Mcdermott, Josh R. Benton, Keara O'Reilly, Galen E. C. Erickson, Jim C. Macdonald

Nebraska Beef Cattle Reports

Summary with Implications

Bunk management is crucial for modern feedlots, and understanding the ideal time to target a slick bunk is important. A feedlot study compared the effect of providing finishing cattle with 12, 15, 18, 21, or 24 hours of access to feed on performance, carcass characteristics, feeding behavior, and ruminal pH. As access time to feed increased, feed intake and day-to-day variation of feed intake increased linearly, while gain and feed conversion were unchanged. Cattle with greater access time to feed spent more time per day at the bunk, and consumed feed more slowly. A cubic effect on …

Evaluation Of Lysoforte Extend On Rumen Fermentation Parameters, Rumen And Total Tract Digestion, And Fatty Acid Digestion, Anna Kobza, Dalton Anderson, Jerilyn Hergenreder, Jim C. Macdonald

Nebraska Beef Cattle Reports

Summary with Implications

Supplemental fat fed in finishing diets in recent years has generally increased in price. This digestibility study evaluated LYSOFORTE Extend, a lysophospholipid based nutritional emulsifier, in beef finishing diets containing tallow or corn oil. Five ruminally and duodenally cannulated steers were used in a 5 × 5 Latin Square design. Treatments followed a 2 × 2 +1 factorial: 1) No Oil (negative control), 2) Corn Oil (3.5%), 3) Tallow (3.5%), 4) Corn Oil + LFE (8 g/d), and 5) Tallow + LFE (8 g/d). Cattle fed the negative control diet had greater dry matter intake than cattle …