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2026

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The Multidimensional Online Civic Engagement For Youth (Moce-Y) Scale: Development And Validation, Yue Ni, G. John Geldhof, Kelly D. Chandler, Richard A. Settersten Jr Jan 2026

The Multidimensional Online Civic Engagement For Youth (Moce-Y) Scale: Development And Validation, Yue Ni, G. John Geldhof, Kelly D. Chandler, Richard A. Settersten Jr

Psychology Faculty Publications and Presentations

Online civic engagement among young people may represent a form of positive youthdevelopment in digital spaces. However, its impacts on youth’s well-being remain unclear,partly due to a lack of validated measures that capture the unique features of the internetand incorporate youth voices. To address this gap, we developed and validated a scale ofmultidimensional online civic engagement for youth aged 15 to 25 years (MOCE-Y) using anexploratory sequential mixed-methods approach. Qualitative interviews with 12 youth sup-ported the multidimensional structure derived from literature, from which we developed aninitial 40-item scale. Exploratory (N ¼ 159) and confirmatory (N ¼ 244) factor analyses withtwo …


Assessment Of Parental Knowledge And Anxiety Surrounding The Informed Consent Discussion For Neonatal Cardiac Interventions, Kristal Mancuso Hock Jan 2026

Assessment Of Parental Knowledge And Anxiety Surrounding The Informed Consent Discussion For Neonatal Cardiac Interventions, Kristal Mancuso Hock

ETDs from 2020-2029

The purpose of this dissertation was to explore the complexities of the informed consent (IC) process in the context of neonatal cardiac interventions, with a focus on parental knowledge and anxiety during decision-making. Across three manuscripts, this work examined conceptual dimensions, feasibility, and acceptability of a new prenatal treatment (palliative care (PC) support sessions), and the effect sizes of this new treatment on parental knowledge and anxiety levels surrounding the IC discussion for neonatal cardiac palliations. The first manuscript employed dimensional analysis to conduct a concept analysis of IC in surgical care. The review of 27 publications revealed three distinct …


86 West Holdings Llc V. Singh Jan 2026

86 West Holdings Llc V. Singh

All Decisions

In a non-primary residence holdover, the court upheld the successor-tenant's succession claim after a seven-day trial. The landlord sought possession alleging the tenant of record failed to maintain primary residence. The key legal issue involved the successor-tenant's two periods of incarceration, which the court determined did not interrupt the required two-year co-residency period for succession under Rent Stabilization Law §2523.5(b)(3)(iii). The court found the successor-tenant proved co-residency with the tenant of record from 2010 through December 31, 2014, and dismissed the landlord's petition with prejudice, granting judgment for the successor-tenant.


Examining Patterns In Childcare Utilization For Low-Wage Workers And Their Access To Government And Employer-Based Childcare Supports, Amrita Kulkarni, Laura Brugger, Stephen Roll, Guangli Zhang, Mathieu Despard Jan 2026

Examining Patterns In Childcare Utilization For Low-Wage Workers And Their Access To Government And Employer-Based Childcare Supports, Amrita Kulkarni, Laura Brugger, Stephen Roll, Guangli Zhang, Mathieu Despard

Center for Social Development Research

For parents in the United States, childcare costs are one of the largest expenses in the budget. This brief examines the childcare arrangements low-wage workers adopt, their difficulties in accessing and affording childcare, and the extent to which they utilize childcare benefits offered by their employers or the government. To do so, we use on data from the Workforce Economic Inclusion and Mobility (WEIM) survey of a nationally representative sample of low-wage U.S. workers. For these analyses, the sample includes only workers with children under the age of 6.


Newsletter 2026.01.28, Fcrh Honors Program Jan 2026

Newsletter 2026.01.28, Fcrh Honors Program

What's Going On, Honors? (2025-26)

No abstract provided.


Can A Fish Serve As An Environmental Bellwether?, Mark Wanner Jan 2026

Can A Fish Serve As An Environmental Bellwether?, Mark Wanner

UNH Today Archive

No abstract provided.


2026-01-28 Philosophy, Academic Freedom And The Health Of Democracy, Vinod Acharya Jan 2026

2026-01-28 Philosophy, Academic Freedom And The Health Of Democracy, Vinod Acharya

The Spectator Online

No abstract provided.


Decentralization And Trust: Institutional Design For Effective Governance, Michael A. Nelson Jan 2026

Decentralization And Trust: Institutional Design For Effective Governance, Michael A. Nelson

University Research

This study examines the relationship between decentralization and public trust in the civil service using a multidimensional framework that extends beyond conventional fiscal measures. Drawing on indicators of regional and local government autonomy across 47 countries from 1995 to 2018, the analysis yields four findings. Trust is higher when local governments, rather than regional authorities, lead service delivery; greater subnational financial self-reliance is positively associated with trust; oversight by higher tiers enhances accountability and citizen perceptions; and shared-rule arrangements that involve regional governments in national decision-making further bolster trust. Overall, the findings highlight the limits of fiscal decentralization alone and …


Heatwaves Compounded With Flflooding In Tampa Bay: Intensity, Frequency, And Risks, Lucas Nofsinger, Ogugua Onochie, Sidharth Sudheer, Alejandra R. Enriquez Jan 2026

Heatwaves Compounded With Flflooding In Tampa Bay: Intensity, Frequency, And Risks, Lucas Nofsinger, Ogugua Onochie, Sidharth Sudheer, Alejandra R. Enriquez

Making Waves REU

Rising coastal temperatures and intensity of heatwaves increasing the extremity of flooding events pose growing threats to the health and resilience of coastal communities. Building on recent global compound hazard assessments (Zhou et al., 2024), this study provides a high-resolution analysis of heatwave trends across the Tampa Bay area from 1993 to 2026 using land surface temperatures (LST). To evaluate compound hazards, flood maps were sourced for comparison. LST’s were derived from 30 m Landsat imagery to characterize temperature increases in the region. Utilizing LST climatology and land cover maps, spatial and temporal warming trends were investigated. Areas of rapid …


Mental Health Professional Shortages In Washington State, Lanh Tran Jan 2026

Mental Health Professional Shortages In Washington State, Lanh Tran

Selected Social Change Portfolios in Prevention, Intervention, and Consultation

Goal Statement

The social change portfolio aims to highlight the persistent shortage of mental health professionals in Washington State, the reasons behind this crisis, and to find sustainable solutions to reduce burnout.


Significant Findings

Washington State is experiencing a shortage of mental health professionals in the urban and rural areas. The most significant contributing factor is professionals' feeling burnt out. This happened before the pandemic, but it escalated significantly afterwards. Burnout is physical and emotional exhaustion coupled with self-doubt because of a psychological response for people in roles of caring and supporting others. In Washington State, there is 1 mental …


2026-01-28 One Year In: How Trump’S Second Presidency Is Taking Shape, Kean Mathis Jan 2026

2026-01-28 One Year In: How Trump’S Second Presidency Is Taking Shape, Kean Mathis

The Spectator Online

No abstract provided.


A Comparison Of The Effectiveness Of Salmonella-Shigella (Ss) Agar And Xylose Lysine Deoxycholate (Xld) Agar In Supporting The Growth Of Salmonella Sp. And Shigella Sp., Ika Ningsih, Kharisma Winnie Chryssantium Tiro Jan 2026

A Comparison Of The Effectiveness Of Salmonella-Shigella (Ss) Agar And Xylose Lysine Deoxycholate (Xld) Agar In Supporting The Growth Of Salmonella Sp. And Shigella Sp., Ika Ningsih, Kharisma Winnie Chryssantium Tiro

Indonesian Journal of Medical Chemistry and Bioinformatics

Diarrheal diseases caused by Salmonella sp. and Shigella sp. are among the most significant public health challenges worldwide, especially among children. To identify these bacteria, Salmonella-Shigella (SS) and Xylose Lysine Deoxycholate (XLD) agar media are used, which are selective and differential for Salmonella sp. and Shigella sp. Although these media share similar properties and functions for growing Salmonella sp. and Shigella sp., results from previous studies differ from those obtained in tests conducted by the Department of Microbiology, Faculty of Medicine, University of Indonesia. This laboratory-based experimental study used serial dilution with three replicates (triplicate). Based on SNI 2897 of …


Uc Agenda 2026-01-28, Northern Illinois University Jan 2026

Uc Agenda 2026-01-28, Northern Illinois University

University Council Archives

No abstract provided.


Bringing The Heat: Optimizing Current Feed Warming Practices For Hospitalized Infants, Kaitlyn Ballard, Christine Nguyen, Madison Pavelka, David Rice, Yesica Rivas, Hannah Gabrielle Sellers, Nathan Xie Jan 2026

Bringing The Heat: Optimizing Current Feed Warming Practices For Hospitalized Infants, Kaitlyn Ballard, Christine Nguyen, Madison Pavelka, David Rice, Yesica Rivas, Hannah Gabrielle Sellers, Nathan Xie

2025

No abstract provided.


What's New With Journal Subscriptions And Open Access Fee Waivers (2026), Rebecca Bealer Mlis, Lsu Health Libraries Jan 2026

What's New With Journal Subscriptions And Open Access Fee Waivers (2026), Rebecca Bealer Mlis, Lsu Health Libraries

Library Instruction

2026 brings a few changes to journals and fee waivers offered by the Library. We will cover journals added and cancelled, as well as continuing and new open access and fee waiver agreements. Recorded session from the information session that took place on January 28, 2026.


Spartan Daily, January 28, 2026, San Jose State University, School Of Journalism And Mass Communications Jan 2026

Spartan Daily, January 28, 2026, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2026

Volume 166, Issue 3


Translating Cardiovascular Ion Channel And Ca2+ Signalling Mechanisms Into Therapeutic Insights, Gonzalo Hernandez Hernandez, Donald M Bers, Patrick M Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F Harraz, Na Li, Thomas A Longden, William E Louch, Madeline Nieves-Cintron, Matthew A Nystoriak, Walter Lee Murfee, Przemysław B Radwański, Swapnil K Sonkusare, Manuel F Navedo, Eleonora Grandi Jan 2026

Translating Cardiovascular Ion Channel And Ca2+ Signalling Mechanisms Into Therapeutic Insights, Gonzalo Hernandez Hernandez, Donald M Bers, Patrick M Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F Harraz, Na Li, Thomas A Longden, William E Louch, Madeline Nieves-Cintron, Matthew A Nystoriak, Walter Lee Murfee, Przemysław B Radwański, Swapnil K Sonkusare, Manuel F Navedo, Eleonora Grandi

Faculty, Staff and Students Publications

Cardiovascular diseases remain the leading cause of mortality worldwide, driven by complex, multi-scale mechanisms that span molecular, cellular, and organ-level dysfunction. Effective therapeutic strategies therefore require integrative approaches that link fundamental biology to translational applications. The 8th UC Davis CardioVascular Symposium gathered experts in ion channel biophysics, Ca2+ signaling, arrhythmia mechanisms, and cardiovascular physiology to discuss recent advances and define emerging priorities. This white paper synthesizes the key themes and consensus points that emerged, highlighting progress in two core domains: (1) advances in cardiovascular electrophysiology and arrhythmia mechanisms, and (2) spatiotemporal dynamics of Ca2+ signaling in cardiac and vascular function …


Kdm4a Promotes Nepc Progression Through Regulation Of Myc Expression, Xin Liang, Xiaoxuan Wang, Fei Yuan, Feng Wang, Anh G Hoang, Xingzhi Song, Peter Shepherd, Derek Liang, Jessica Suh, Jordan Contreras, Thisawin Dang, Cindy Yan, Brandon Figueroa, Mathias Mazzocco, Athena Luo, Bijeta Pradhan, Jiwon Park, Mirrah Bashir, Miao Zhang, Eric Metzger, Roland Schüle, Abhinav K Jain, Ellen Karasik, Daniel Frigo, Barbara A Foster, Min Gyu Lee, Paul Corn, Christopher J Logothetis, Ana Aparicio, Nora Navone, Patricia Troncoso, Zhi Tan, Jianhua Zhang, Sue-Hwa Lin, Guocan Wang Jan 2026

Kdm4a Promotes Nepc Progression Through Regulation Of Myc Expression, Xin Liang, Xiaoxuan Wang, Fei Yuan, Feng Wang, Anh G Hoang, Xingzhi Song, Peter Shepherd, Derek Liang, Jessica Suh, Jordan Contreras, Thisawin Dang, Cindy Yan, Brandon Figueroa, Mathias Mazzocco, Athena Luo, Bijeta Pradhan, Jiwon Park, Mirrah Bashir, Miao Zhang, Eric Metzger, Roland Schüle, Abhinav K Jain, Ellen Karasik, Daniel Frigo, Barbara A Foster, Min Gyu Lee, Paul Corn, Christopher J Logothetis, Ana Aparicio, Nora Navone, Patricia Troncoso, Zhi Tan, Jianhua Zhang, Sue-Hwa Lin, Guocan Wang

Faculty, Staff and Students Publications

Neuroendocrine prostate cancer (NEPC) is a highly aggressive and lethal subtype of prostate cancer (PCa) that often emerges in response to androgen receptor pathway inhibitors (ARPIs), which are widely used in treating metastatic castration-resistant and hormone-sensitive prostate cancer. The incidence of NEPC is increasing, yet effective therapeutic strategies remain limited due to an incomplete understanding of its molecular drivers. Through transcriptomic analyses of human prostate tumor samples, we identified the histone lysine demethylase KDM4A as uniquely overexpressed in human and mouse NEPC compared to prostate adenocarcinoma. Functional validation demonstrated that KDM4A is a key regulator of NEPC progression and a …


Reframing The At-Risk Discourse: From Victim Blaming To Nurturing Resilience, Romana Mathews Jan 2026

Reframing The At-Risk Discourse: From Victim Blaming To Nurturing Resilience, Romana Mathews

Electronic Theses and Dissertations Archive

Each year, approximately 1.2 million students drop out of high school in the United States—about one every 26 seconds (National Center for Education Statistics, 2023). This trend calls for a reexamination of how we understand and support students labeled “at-risk.” Traditional deficit-based models focus narrowly on challenges, often overlooking how students actively build resilience to navigate adversity. This study explores how successful high school graduates from rural Title I schools in the southern United States interpret the “at-risk” label and develop resilience. Guided by two research questions (1) How do these graduates interpret and make meaning of the “at-risk” label? …


Assessment Of Knowledge, Attitude And Behaviors Towards Invasive Meningococcal Disease And Its Vaccination Among Young Adults In Saudi Arabia: A Cross-Sectional Study, Wesam Osama Mandoura, Anmar Abdullah Bijar, Anmar Aiman Rehbini, Ghali Ghalib Alhindi Jan 2026

Assessment Of Knowledge, Attitude And Behaviors Towards Invasive Meningococcal Disease And Its Vaccination Among Young Adults In Saudi Arabia: A Cross-Sectional Study, Wesam Osama Mandoura, Anmar Abdullah Bijar, Anmar Aiman Rehbini, Ghali Ghalib Alhindi

Saudi Toxicology Journal

Background: Invasive meningococcal disease (IMD) remains a life-threatening infection associated with high mortality and long-term morbidity. Effective vaccines are available but meningococcal vaccination in Saudi Arabia is not mandatory outside specific high-risk groups. Public knowledge, attitudes and behaviors (KAB) toward IMD and its vaccination play a pivotal role in disease prevention and vaccine uptake. Methods: A cross-sectional survey was conducted among 382 residents of Saudi Arabia between July and August 2024 using a validated, Arabictranslated questionnaire distributed via social media. The survey assessed socio-demographic characteristics, knowledge of IMD, attitudes toward vaccination, vaccination behaviors and sources of information. Knowledge scores were …


Editorial Note: Genai For Academic Writing – Friend Or Foe?, Corina D. Riantoputra, Turro S. Wongkaren, Edo S. Jaya, Laras Sekarasih, Muhammad Abdan Shadiqi Jan 2026

Editorial Note: Genai For Academic Writing – Friend Or Foe?, Corina D. Riantoputra, Turro S. Wongkaren, Edo S. Jaya, Laras Sekarasih, Muhammad Abdan Shadiqi

Makara Human Behavior Studies in Asia

In an article published in Nature titled “ChatGPT listed as author in research papers” Stone-Walker (2023) shocks the academic community with the fact that GenAI tools such as ChatGPT and Gemini have gained a substantive role in the production of knowledge and academic writing. He reports that one research company has published 80 articles produced by GenAI in academic journals.  In the wake of Stone-Walker’s article, many publishers and journal editors set guidelines in relations to the role of GenAI in academic writings. All of them disagree to allow GenAI as an author.  Further, the Stanford University Artificial Intelligence Index …


Editorial: Next-Generation Protacs In Oncology And Beyond: Exploring Therapeutic Targets And Their Degraders, Daiqing Liao, Debasish Bandyopadhyay Jan 2026

Editorial: Next-Generation Protacs In Oncology And Beyond: Exploring Therapeutic Targets And Their Degraders, Daiqing Liao, Debasish Bandyopadhyay

School of Integrative Biological & Chemical Sciences Faculty Publications

No abstract provided.


Staff Education To Enhance Psychiatric Medication Adherence In Psychiatric Care, Emmanuel Nusta Jan 2026

Staff Education To Enhance Psychiatric Medication Adherence In Psychiatric Care, Emmanuel Nusta

Walden Dissertations and Doctoral Studies

Medication non-adherence affects 49% of psychiatric patients and contributes to poor outcomes and increased hospitalizations. At the project site, 40% of patients demonstrated suboptimal adherence and 12 medication-related incidents occurred. Nursing staff lacked specialized training in motivational interviewing and comprehensive adherence assessment. This project developed and implemented an evidence-based educational program to enhance nursing competencies in psychiatric medication adherence counseling. Seven nursing staff members (5 registered nurses, 2 licensed practical nurses) participated in a 90-minute session incorporating the four-domain assessment framework, motivational interviewing techniques, and psychoeducational strategies. The ADDIE framework guided program development with interactive discussions, case-based learning, and role-play …


Pemodelan Regresi Logistik Spasial Pada Kejadian Demam Berdarah Dengue (Dbd) Di Provinsi Jawa Barat Tahun 2023, Valida Ulfa Septiana, Sutanto Priyo Hastono Jan 2026

Pemodelan Regresi Logistik Spasial Pada Kejadian Demam Berdarah Dengue (Dbd) Di Provinsi Jawa Barat Tahun 2023, Valida Ulfa Septiana, Sutanto Priyo Hastono

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Demam Berdarah Dengue (DBD) merupakan salah satu penyakit menular yang masih menjadi masalah kesehatan masyarakat di Indonesia, termasuk Provinsi Jawa Barat, dengan rata-rata kejadian yang lebih tinggi dari rata-rata nasional. Analisis spasial diperlukan untuk memahami pola penyebaran DBD, mengingat adanya kemungkinan pengaruh antar wilayah. Penelitian ini bertujuan untuk menganalisis pengaruh faktor sosio-demografi, faktor perilaku, serta efek spasial kedekatan geografis antar wilayah terhadap kejadian DBD di Provinsi Jawa Barat tahun 2023. Penelitian ini menggunakan desain potong lintang dengan unit analisis 27 kabupaten/kota di Jawa Barat tahun 2023. Data sekunder diperoleh dari Survei Kesehatan Indonesia 2023 dan Jawa Barat dalam Angka 2024. …


Workforce Economic Inclusion And Stability In The United States And United Kingdom: Summary Findings, Mathieu Despard, Stephen Roll, Kristian Fuzi, Adele Atkinson, Louise Overton Jan 2026

Workforce Economic Inclusion And Stability In The United States And United Kingdom: Summary Findings, Mathieu Despard, Stephen Roll, Kristian Fuzi, Adele Atkinson, Louise Overton

Center for Social Development Research

Through a partnership between the Center for Social Development (CSD) at Washington University in St. Louis (United States) and the Centre on Household Savings and Asset Management (CHASM) at the University of Birmingham (United Kingdom),the Workforce Economic Inclusion and Mobility (WEIM) project has explored a host of issues affecting low-wage workers and their families in the United States and the United Kingdom. CSD and CHASM analyzed survey datasets from their respective countries to produce a set of insights regarding the challenges low-wage workers and their families face. This Research Summary discusses and synthesizes key findings organized by cross-cutting themes to …


Barriers To Entry, Barriers To Exit: Exploring The Relationship Between Administrative Burdens And Work Disincentives In Public Benefits Programs, Stephen Roll, Guangli Zhang, Mathieu Despard Jan 2026

Barriers To Entry, Barriers To Exit: Exploring The Relationship Between Administrative Burdens And Work Disincentives In Public Benefits Programs, Stephen Roll, Guangli Zhang, Mathieu Despard

Center for Social Development Research

Through the Workforce Economic Inclusion and Mobility project, the Center for Social Development has explored how the design of the U.S. public benefits system creates barriers to the economic stability and mobility of low-wage workers. The first of these barriers is the administrative burdens embedded in public benefits, which refers to the difficulties and stresses potential beneficiaries experience learning about a program, complying with program rules, or interacting with program staff. The second of these barriers is the work and savings disincentives many public benefits programs create through their eligibility rules, which can punish beneficiaries for earning or saving more …


Designing Inclusive Newborn Sequencing Research: Insights From Parents In Underrepresented Communities, Maya C Del Rosario, Sheyenne A Walmsley, Barbara W Harrison, Crystal T Stephens, Bethany Zettler, Greysha Rivera-Cruz, Priyal Agrawal, Amy Brower, Stephanie Chigbu, Kurt D Christensen, Casie A Genetti, Richetta Givens, Nina B Gold, Inez V Reeves, Isabella Schichter, Habib Shariat, Sandra Simon, Hadley Stevens Smith, Melissa Uveges, Robert C Green, Ingrid A Holm, Stacey Pereira Jan 2026

Designing Inclusive Newborn Sequencing Research: Insights From Parents In Underrepresented Communities, Maya C Del Rosario, Sheyenne A Walmsley, Barbara W Harrison, Crystal T Stephens, Bethany Zettler, Greysha Rivera-Cruz, Priyal Agrawal, Amy Brower, Stephanie Chigbu, Kurt D Christensen, Casie A Genetti, Richetta Givens, Nina B Gold, Inez V Reeves, Isabella Schichter, Habib Shariat, Sandra Simon, Hadley Stevens Smith, Melissa Uveges, Robert C Green, Ingrid A Holm, Stacey Pereira

Center for Medical Ethics and Health Policy Staff Publications

Background: It is essential that studies of genomic sequencing (GS) in newborns and children include individuals from under-represented racial and ethnic groups (URG) to ensure future applications are equitably implemented. We conducted interviews with parents from URG to better understand their perspectives on GS research, develop strategies to reduce barriers to enrollment, and facilitate research participation.

Methods: Semi-structured interviews with 50 parents from URG.

Results: Nearly all parents said they would be interested in participating in an infant GS study. Parents were interested in participating in GS research for reasons including clinical utility, personal utility, and/or family health benefits. Deterrents …


The Bg News January 28, 2026, Bowling Green State University Jan 2026

The Bg News January 28, 2026, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. January 28, 2026. Volume 105-Issue 15.


The Effects Of Ovine-Derived Reinforced Tissue Matrix Surrounding Silicone-Based Implants In A Rat Prepectoral Reconstruction Model, Sai L Pinni, Cameron Martin, Nicholas Fadell, Xiaochao Xia, Evan Marsh, Lauren Schellhardt, Xiaowei Li, Matthew D Wood, Justin M Sacks Jan 2026

The Effects Of Ovine-Derived Reinforced Tissue Matrix Surrounding Silicone-Based Implants In A Rat Prepectoral Reconstruction Model, Sai L Pinni, Cameron Martin, Nicholas Fadell, Xiaochao Xia, Evan Marsh, Lauren Schellhardt, Xiaowei Li, Matthew D Wood, Justin M Sacks

2020-Current year OA Pubs

Silicone-based implants have been widely used in breast reconstruction but have also been associated with poorly understood complications, including pathologic foreign body responses such as capsular contracture. In this study, we leveraged 3D-printing technology to generate silicone-based implants in a novel, anatomically relevant, prepectoral rat model. We used this model to evaluate the response to an extracellular matrix-based product: ovine-derived reinforced tissue matrix (RTM). Two-piece negative molds were developed through computer-aided design and 3D-printed. The molds were filled with various polydimethylsiloxane mixtures and dip-coated to fabricate implants. Implant material characterization revealed that the implants retained the original 3D-printed mold shape …


Defining The Heterogeneous Molecular Landscape Of Lung Cancer Cell Responses To Epigenetic Inhibition, Chuwei Lin, Catherine M Sniezek, Christopher D Mcgann, Rashmi Karki, Ross M Giglio, Benjamin A Garcia, José L Mcfaline-Figueroa, Devin K Schweppe Jan 2026

Defining The Heterogeneous Molecular Landscape Of Lung Cancer Cell Responses To Epigenetic Inhibition, Chuwei Lin, Catherine M Sniezek, Christopher D Mcgann, Rashmi Karki, Ross M Giglio, Benjamin A Garcia, José L Mcfaline-Figueroa, Devin K Schweppe

2020-Current year OA Pubs

Epigenetic inhibitors exhibit powerful antiproliferative and anticancer activities. However, cellular responses to small-molecule epigenetic inhibition are heterogeneous and dependent on factors such as the genetic background and metabolic state of cells, as well as on-/off-target engagement of individual small-molecule compounds. The molecular study of the extent of this heterogeneity often measures changes in a single cell line. To more comprehensively profile the effects of small-molecule perturbations and their influence on heterogeneous cellular responses, we present a molecular resource based on the quantification of chromatin, proteome, and transcriptome remodeling due to histone deacetylase inhibitors (HDACi) in non-isogenic cell lines. Through quantitative …